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Tomi Pastinen

Research Profile

Genes & Molecular Sequences

Physiology

Procedures

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Publications

TOP 3
Dominique J Verlaan; Dave Sirois-Gagnon; Veronique Adoue; Patrick Beaulieu; Joana Dias; Bing Ge; Vonda Koka; Kevin C L Lam; Catherine Laprise; Mathieu Larivière; MC Ouimet; Tomi Pastinen; Daniel Sinnett
Promoter polymorphisms in CHI3L1 are associated with asthma.
Soizik Berlivet; Vonda Koka; Tony Kwan; Sanny Moussette; MC Ouimet; Tomi Pastinen; Daniel Sinnett; Dominique J Verlaan; Abeer Al Tuwaijri; Anna K Naumova
Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines.
Philippe Sanseau; Tomi Pastinen; J Brent Richards; Pankaj Agarwal; Michael R Barnes; Lon R Cardon; Vincent Mooser
Use of genome-wide association studies for drug repositioning.

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All Publications

2012: Dominique J Verlaan; Dave Sirois-Gagnon; Veronique Adoue; Patrick Beaulieu; Joana Dias; Bing Ge; Vonda Koka; Kevin C L Lam; Catherine Laprise; Mathieu Larivière; MC Ouimet; Tomi Pastinen; Daniel Sinnett
Promoter polymorphisms in CHI3L1 are associated with asthma.
The Journal of allergy and clinical immunology 2012;130(2):533-5.
2012: Soizik Berlivet; Vonda Koka; Tony Kwan; Sanny Moussette; MC Ouimet; Tomi Pastinen; Daniel Sinnett; Dominique J Verlaan; Abeer Al Tuwaijri; Anna K Naumova
Interaction between genetic and epigenetic variation defines gene expression patterns at the asthma-associated locus 17q12-q21 in lymphoblastoid cell lines.
Human genetics 2012;131(7):1161-71.
2012: Philippe Sanseau; Tomi Pastinen; J Brent Richards; Pankaj Agarwal; Michael R Barnes; Lon R Cardon; Vincent Mooser
Use of genome-wide association studies for drug repositioning.
Nature biotechnology 2012;30(4):317-20.
2012: Jonas Carlsson Almlöf; Jessy Brocheton; François Cambien; Abigail Crisp-Hihn; Panos Deloukas; Camilla Enström; Jeanette Erdmann; Nicola Foad; Bing Ge; Tiphaine Godefroy; Alison H Goodall; Harald H H Göring; Rhian Gwilliam; Christian Hengstenberg; Jennifer Jolley; Ulrika Liljedahl; Heather Lloyd-Jones; Anders Lundmark; Per Lundmark; Maouche Seraya; Willem H Ouwehand; Tomi Pastinen; Carole Proust; Catherine M Rice; Nilesh J Samani; Jennifer G Sambrook; Heribert Schunkert; Jonathan Stephens; Ann-Christine Syvänen
Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression.
PloS one 2012;7(12):e52260.
2012: Jean-François Lefebvre; Stephen B Montgomery; Tomi Pastinen; Emilio Vello; Emmanouil T Dermitzakis; Bing Ge; Damian Labuda
Genotype-based test in mapping cis-regulatory variants from allele-specific expression data.
PloS one 2012;7(6):e38667.
2011: Emilie Lalonde; Kevin C H Ha; Zibo Wang; Amandine Bemmo; Claudia L Kleinman; Tony Kwan; Tomi Pastinen; Jacek Majewski
RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression.
Genome research 2011;21(4):545-54.
2011: Jacek Majewski; Tomi Pastinen
The study of eQTL variations by RNA-seq: from SNPs to phenotypes.
Trends in genetics : TIG 2011;27(2):72-9.
2011: Alicia Schiavi; Veronique Adoue; Stephan Busche; Nicholas Light; Tomi Pastinen
Human genetics in full resolution.
Genome biology 2011;12(11):309.
2011: Malgorzata Labuda; Tomi Pastinen; Sophie Laberge; Patrick Beaulieu; Denis Bérubé; Julie Brière; Maja Krajinovic
Phosphodiesterase type 4D gene polymorphism: association with the response to short-acting bronchodilators in paediatric asthma patients.
Mediators of inflammation 2011;2011():301695.
2011: Lisanne Morcos; Dmitry K Pokholok; Dominique J Verlaan; Bing Ge; Kevin L Gunderson; Vonda Koka; Kevin C L Lam; Alexandre Montpetit; Tomi Pastinen
Genome-wide assessment of imprinted expression in human cells.
Genome biology 2011;12(3):R25.
2011: Elin Grundberg; Veronique Adoue; Tony Kwan; Bing Ge; Qing Ling Duan; Kevin C L Lam; Vonda Koka; Andreas Kindmark; Scott T Weiss; Kelan Tantisira; Hans Mallmin; Benjamin A Raby; Olle Nilsson; Tomi Pastinen
Global analysis of the impact of environmental perturbation on cis-regulation of gene expression.
PLoS genetics 2011;7(1):e1001279.
2010: Thomas Rio Frio; Josée Lavoie; Nancy Hamel; Felipe C Geyer; Yaël B Kushner; David J Novak; Landon Wark; Cristian Capelli; Jorge S Reis-Filho; Sabine Mai; Tomi Pastinen; Marc D Tischkowitz; Victoria A Marcus; William D Foulkes
Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia.
The New England journal of medicine 2010;363(27):2628-37.
2010: Amy Murphy; Jen-Hwa Chu; Mousheng Xu; Vincent J Carey; Ross Lazarus; Andy Liu; Stanley J Szefler; Robert Strunk; Karen Demuth; Mario Castro; Nadia N Hansel; Gregory B Diette; Becky M Vonakis; N FRANKLIN ADKINSON; Barbara J Klanderman; Jody Senter-Sylvia; John Ziniti; Christoph Lange; Tomi Pastinen; Benjamin A Raby
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.
Human molecular genetics 2010;19(23):4745-57.
2010: Yann Joly; Bartha M Knoppers; Timothy Caulfield; Eef Harmsen; Tomi Pastinen
The commercialization of genomic research in Canada.
Healthcare policy = Politiques de santé 2010;6(2):24-32.
2010: Ron Do; Swneke D Bailey; Guillaume Paré; Alexandre Montpetit; Katia Desbiens; Thomas J Hudson; Salim Yusuf; Claude Bouchard; Daniel Gaudet; Louis Pérusse; Sonia Anand; Marie-Claude Vohl; Tomi Pastinen; James C Engert
Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.
Circulation. Cardiovascular genetics 2010;3(5):454-61.
2010: Tomi Pastinen
Genome-wide allele-specific analysis: insights into regulatory variation.
Nature reviews. Genetics 2010;11(8):533-8.
2010: Yi-Hsiang Hsu; M Carola Zillikens; Scott G Wilson; Charles R Farber; Serkalem Demissie; Nicole Soranzo; Estelle Bianchi; Elin Grundberg; Liming Liang; J Brent Richards; Karol Estrada; Yanhua Zhou; Atila Van Nas; Miriam F Moffatt; Guangju Zhai; Albert Hofman; Joyce B van Meurs; Huibert A P Pols; Roger I Price; Olle Nilsson; Tomi Pastinen; L Adrienne Cupples; Aldons J Lusis; Eric E Schadt; Serge Ferrari; André G Uitterlinden; Fernando Rivadeneira; Timothy D Spector; David Karasik; Douglas P Kiel
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
PLoS genetics 2010;6(6):e1000977.
2010: James R Wagner; Bing Ge; Dmitry Pokholok; Kevin L Gunderson; Tomi Pastinen; Mathieu Blanchette
Computational analysis of whole-genome differential allelic expression data in human.
PLoS computational biology 2010;6(7):e1000849.
2010: Aabida Saferali; Elin Grundberg; Soizik Berlivet; Hugues Beauchemin; Lisanne Morcos; Constantin Polychronakos; Tomi Pastinen; Jinko Graham; Brad McNeney; Anna K Naumova
Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines.
Epigenetics : official journal of the DNA Methylation Society 2010;5(1):50-60.
2009: Bing Ge; Dmitry K Pokholok; Tony Kwan; Elin Grundberg; Lisanne Morcos; Dominique J Verlaan; Jennie Le; Vonda Koka; Kevin C L Lam; Vincent Gagné; Joana Dias; Rose Hoberman; Alexandre Montpetit; Marie-Michele Joly; Edward Harvey; Daniel Sinnett; Patrick Beaulieu; Robert Hamon; Alexandru Graziani; Ken Dewar; Eef Harmsen; Jacek Majewski; Harald HH Goring; Anna K Naumova; Mathieu Blanchette; Kevin L Gunderson; Tomi Pastinen
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis.
Nature genetics 2009;41(11):1216-22.
2009: Elin Grundberg; Tony Kwan; Bing Ge; Kevin C L Lam; Vonda Koka; Andreas Kindmark; Hans Mallmin; Joana Dias; Dominique J Verlaan; MC Ouimet; Daniel Sinnett; Fernando Rivadeneira; Karol Estrada; Albert Hofman; Joyce M van Meurs; André Uitterlinden; Patrick Beaulieu; Alexandru Graziani; Eef Harmsen; Osten Ljunggren; Claes Ohlsson; Dan Mellström; Magnus K Karlsson; Olle Nilsson; Tomi Pastinen
Population genomics in a disease targeted primary cell model.
Genome research 2009;19(11):1942-52.
2009: Hui-Qi Qu; Dominique J Verlaan; Bing Ge; Yang Lu; Hui-Qi Qu; Rosemarie Grabs; Eef Harmsen; Thomas J Hudson; Hakon Hakonarson; Tomi Pastinen; Constantin Polychronakos
A cis-acting regulatory variant in the IL2RA locus.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5158-62.
2009: Dominique J Verlaan; Soizik Berlivet; Gary M Hunninghake; Anne-Marie Madore; Mathieu Larivière; Sanny Moussette; Elin Grundberg; Tony Kwan; Manon Ouimet; Bing Ge; Rose Hoberman; Marcin Swiatek; Joana Dias; Kevin C L Lam; Vonda Koka; Eef Harmsen; Manuel Soto-Quiros; Lydiana Avila; Juan C Celedón; Scott Weiss; Ken Dewar; Daniel Sinnett; Catherine Laprise; Benjamin A Raby; Tomi Pastinen; Anna K Naumova
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
American journal of human genetics 2009;85(3):377-93.
2009: Rose Hoberman; Joana Dias; Bing Ge; Eef Harmsen; Michael Mayhew; Dominique J Verlaan; Tony Kwan; Ken Dewar; Mathieu Blanchette; Tomi Pastinen
A probabilistic approach for SNP discovery in high-throughput human resequencing data.
Genome research 2009;19(9):1542-52.
2009: Tony Kwan; Elin Grundberg; Vonda Koka; Bing Ge; Kevin C L Lam; Christel Dias; Andreas Kindmark; Hans Mallmin; Osten Ljunggren; Fernando Rivadeneira; Karol Estrada; Joyce B van Meurs; Andre Uitterlinden; Magnus Karlsson; Claes Ohlsson; Dan Mellström; Olle Nilsson; Tomi Pastinen; Jacek Majewski
Tissue effect on genetic control of transcript isoform variation.
PLoS genetics 2009;5(8):e1000608.
2009: Mario Falchi; Veronique Bataille; Nicholas K Hayward; David L Duffy; Julia Newton-Bishop; Tomi Pastinen; Alessandra Cervino; Zhen Z Zhao; Panos Deloukas; Nicole Soranzo; David E Elder; Jennifer H Barrett; Nicholas G Martin; D Timothy Bishop; Grant W Montgomery; Timothy D Spector
Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.
Nature genetics 2009;41(8):915-9.
2009: Jordan P Lerner-Ellis; Natascia Anastasio; Junhui Liu; David Coelho; Terttu Suormala; Martin Stucki; Amanda D Loewy; Scott Gurd; Elin Grundberg; Chantal F Morel; David Watkins; Matthias R Baumgartner; Tomi Pastinen; David S Rosenblatt; Brian Fowler
Spectrum of mutations in MMACHC, allelic expression, and evidence for genotype-phenotype correlations.
Human mutation 2009;30(7):1072-81.
2009: Amanda D Loewy; Kirsten M Niles; Natascia Anastasio; David Watkins; Josée Lavoie; Jordan P Lerner-Ellis; Tomi Pastinen; Jacquetta M Trasler; David S Rosenblatt
Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.
Molecular genetics and metabolism 2009;96(4):261-7.
2009: Dominique J Verlaan; Bing Ge; Elin Grundberg; Rose Hoberman; Kevin C L Lam; Vonda Koka; Joana Dias; Scott Gurd; Nicolas W Martin; Hans Mallmin; Olof Nilsson; Eef Harmsen; Ken Dewar; Tony Kwan; Tomi Pastinen
Targeted screening of cis-regulatory variation in human haplotypes.
Genome research 2009;19(1):118-27.
2008: Snaevar Sigurdsson; Gunnel Nordmark; Sophie Garnier; Elin Grundberg; Tony Kwan; Olof Nilsson; Maija-Leena Eloranta; Iva Gunnarsson; Elisabet Svenungsson; Gunnar Sturfelt; Anders A Bengtsson; Andreas Jönsen; Lennart Truedsson; Solbritt Rantapää-Dahlqvist; Catharina Eriksson; Gunnar V Alm; Harald HH Goring; Tomi Pastinen; Ann-Christine Syvänen; Lars Rönnblom
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
Human molecular genetics 2008;17(18):2868-76.
2008: Elin Grundberg; Helena Brändström; Kevin C L Lam; Scott Gurd; Bing Ge; Eef Harmsen; Andreas Kindmark; Osten Ljunggren; Hans Mallmin; Olle Nilsson; Tomi Pastinen
Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells.
Physiological genomics 2008;33(3):301-11.
2007: Elin Grundberg; E M C Lau; Tomi Pastinen; Andreas Kindmark; Olof Nilsson; Osten Ljunggren; Dan Mellström; Eric Orwoll; Inga Redlund-Johnell; Anna Holmberg; Scott Gurd; Ping Chung Leung; Timothy Kwok; Claes Ohlsson; Hans Mallmin; Helena Brändström
Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(6):832-40.
2007: Damian Labuda; Catherine Labbé; Sylvie Langlois; Jean-François Lefebvre; Virginie Freytag; Claudia Moreau; Jakub Sawicki; Patrick Beaulieu; Tomi Pastinen; Thomas J Hudson; Daniel Sinnett
Patterns of variation in DNA segments upstream of transcription start sites.
Human mutation 2007;28(5):441-50.
2006: K Tremblay; Mathieu Lemire; V Provost; Tomi Pastinen; Yannick Renaud; A J Sandford; M Laviolette; Thomas J Hudson; Catherine Laprise
Association study between the CX3CR1 gene and asthma.
Genes and immunity 2006;7(8):632-9.
2006: Tomi Pastinen; Bing Ge; Thomas J Hudson
Influence of human genome polymorphism on gene expression.
Human molecular genetics 2006;15 Spec No 1():R9-16.
2006: Peter D Lee; Bing Ge; Celia M T Greenwood; Daniel Sinnett; Yannick Fortin; Sebastien Brunet; Anny Fortin; Marina Takane; Emil Skamene; Tomi Pastinen; Michael Hallett; Thomas J Hudson; Robert Sladek
Mapping cis-acting regulatory variation in recombinant congenic strains.
Physiological genomics 2006;25(2):294-302.
2005: Tomi Pastinen; Bing Ge; Scott Gurd; Tiffany Gaudin; Carole Dore; Mathieu Lemire; Pierre Lepage; Eef Harmsen; Thomas J Hudson
Mapping common regulatory variants to human haplotypes.
Human molecular genetics 2005;14(24):3963-71.
2005: Stuart J Macdonald; Tomi Pastinen; Anthony D Long
The effect of polymorphisms in the enhancer of split gene complex on bristle number variation in a large wild-caught cohort of Drosophila melanogaster.
Genetics 2005;171(4):1741-56.
2005: Bing Ge; Scott Gurd; Tiffany Gaudin; Carole Dore; Pierre Lepage; Eef Harmsen; Thomas J Hudson; Tomi Pastinen
Survey of allelic expression using EST mining.
Genome research 2005;15(11):1584-91.
2005: Stuart J Macdonald; Tomi Pastinen; Anne Genissel; Theodore W Cornforth; Anthony D Long
A low-cost open-source SNP genotyping platform for association mapping applications.
Genome biology 2005;6(12):R105.
2004: Tomi Pastinen; Thomas J Hudson
Cis-acting regulatory variation in the human genome.
Science (New York, N.Y.) 2004;306(5696):647-50.
2004: Tomi Pastinen; Robert Sladek; Scott Gurd; Alya'a Sammak; Bing Ge; Pierre Lepage; Karine Lavergne; Amelie Villeneuve; Tiffany Gaudin; Helena Brändström; Allon Beck; Andrei Verner; Jade Kingsley; Eef Harmsen; Damian Labuda; Kenneth Morgan; Marie-Claude Vohl; Anna K Naumova; Daniel Sinnett; Thomas J Hudson
A survey of genetic and epigenetic variation affecting human gene expression.
Physiological genomics 2004;16(2):184-93.
2004: Anne Genissel; Tomi Pastinen; Andrea Dowell; Trudy F C Mackay; Anthony D Long
No evidence for an association between common nonsynonymous polymorphisms in delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster.
Genetics 2004;166(1):291-306.
2003: Sergey Nejentsev; Mikko Laaksonen; Pentti J Tienari; Oscar Fernandez; Heather Cordell; Juhani Ruutiainen; Juhani Wikström; Tomi Pastinen; Satu Kuokkanen; Jan Hillert; Jorma Ilonen
Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis.
Human immunology 2003;64(3):345-9.
2002: Karoliina Reunanen; Saara Finnilä; Mikko Laaksonen; Marja-Liisa Sumelahti; Juhani Wikström; Tomi Pastinen; Satu Kuokkanen; Janna Saarela; P Uimari; Juhani Ruutiainen; Jorma Ilonen; Leena Peltonen; Pentti J Tienari
Chromosome 19q13 and multiple sclerosis susceptibility in Finland: a linkage and two-stage association study.
Journal of neuroimmunology 2002;126(1-2):134-42.
2002: Mikko Laaksonen; Tomi Pastinen; Minna Sjöroos; Satu Kuokkanen; Juhani Ruutiainen; Marja-Liisa Sumelahti; Helena Reijonen; Reijo Salonen; Juhani Wikström; Martin Panelius; Jukka Partanen; Pentti J Tienari; Jorma Ilonen
HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.
Journal of neuroimmunology 2002;122(1-2):140-5.
2001: Tomi Pastinen; Markus Perola; Jaakko Ignatius; C Sabatti; Päivi Tainola; M Levander; Ann-Christine Syvänen; Leena Peltonen
Dissecting a population genome for targeted screening of disease mutations.
Human molecular genetics 2001;10(26):2961-72.
2001: M Raitio; Katarina Lindroos; M Laukkanen; Tomi Pastinen; Pertti Sistonen; Antti Sajantila; Ann-Christine Syvänen
Y-chromosomal SNPs in Finno-Ugric-speaking populations analyzed by minisequencing on microarrays.
Genome research 2001;11(3):471-82.
2000: Tomi Pastinen; M Raitio; Katarina Lindroos; Päivi Tainola; Leena Peltonen; Ann-Christine Syvänen
A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays.
Genome research 2000;10(7):1031-42.
1998: Tomi Pastinen; Markus Perola; P Niini; Joseph D Terwilliger; Veikko Salomaa; E Vartiainen; Leena Peltonen; Ann-Christine Syvänen
Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population.
Human molecular genetics 1998;7(9):1453-62.
1998: Tomi Pastinen; Kirsi Liitsola; P Niini; Mika Salminen; Ann-Christine Syvänen
Contribution of the CCR5 and MBL genes to susceptibility to HIV type 1 infection in the Finnish population.
AIDS research and human retroviruses 1998;14(8):695-8.
1998: Tomi Pastinen; Markus Perola
[DNA chips--a new diagnostic revolution?].
Duodecim; lääketieteellinen aikakauskirja 1998;114(9):829, 831.
1998: Pentti J Tienari; Satu Kuokkanen; Tomi Pastinen; Juhani Wikström; Antti Sajantila; M Sandberg-Wollheim; Jukka U Palo; Leena Peltonen
Golli-MBP gene in multiple sclerosis susceptibility.
Journal of neuroimmunology 1998;81(1-2):158-67.
1997: K Wansen; Tomi Pastinen; Satu Kuokkanen; Juhani Wikström; Jukka U Palo; Leena Peltonen; Pentti J Tienari
Immune system genes in multiple sclerosis: genetic association and linkage analyses on TCR beta, IGH, IFN-gamma and IL-1ra/IL-1 beta loci.
Journal of neuroimmunology 1997;79(1):29-36.
1997: Tomi Pastinen; Ants Kurg; Andres Metspalu; Leena Peltonen; Ann-Christine Syvänen
Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays.
Genome research 1997;7(6):606-14.
1996: Tomi Pastinen; J Partanen; Ann-Christine Syvänen
Multiplex, fluorescent, solid-phase minisequencing for efficient screening of DNA sequence variation.
Clinical chemistry 1996;42(9):1391-7.