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Jaromir Pastorek

Research Profile

Chemicals & Drugs

Physiology

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Immunohistochemistry

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Seppo Parkkila; Jerzy Lasota; Jonathan A Fletcher; Wen-Bin Ou; Antti J Kivelä; Kyösti Nuorva; Anna-Kaisa Parkkila; Jyrki Ollikainen; William S Sly; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; Jorma Isola; Markku Miettinen
Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.
Martina Takacova; Tereza Holotnakova; Monika Barathova; Silvia Pastorekova; Juraj Kopacek; Jaromir Pastorek
Src induces expression of carbonic anhydrase IX via hypoxia-inducible factor 1.
Kristiina Nordfors; Joonas A Haapasalo; Miikka Korja; Anssi Niemelä; Jukka Laine; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila; Hannu Haapasalo
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.

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All Publications

2010: Seppo Parkkila; Jerzy Lasota; Jonathan A Fletcher; Wen-Bin Ou; Antti J Kivelä; Kyösti Nuorva; Anna-Kaisa Parkkila; Jyrki Ollikainen; William S Sly; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; Jorma Isola; Markku Miettinen
Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(5):743-50.
2010: Martina Takacova; Tereza Holotnakova; Monika Barathova; Silvia Pastorekova; Juraj Kopacek; Jaromir Pastorek
Src induces expression of carbonic anhydrase IX via hypoxia-inducible factor 1.
Oncology reports 2010;23(3):869-74.
2010: Kristiina Nordfors; Joonas A Haapasalo; Miikka Korja; Anssi Niemelä; Jukka Laine; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila; Hannu Haapasalo
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.
BMC cancer 2010;10():148.
2010: Tereza Holotnakova; Lucia Tylkova; Martina Takacova; Juraj Kopacek; Juraj Petrik; Silvia Pastorekova; Jaromir Pastorek
Role of the HBx oncoprotein in carbonic anhydrase 9 induction.
Journal of medical virology 2010;82(1):32-40.
2009: Alzbeta Hulikova; Miriam Zatovicova; Eliska Svastova; Peter Ditte; Robert Brasseur; Richard Kettmann; Claudiu T Supuran; Juraj Kopacek; Jaromir Pastorek; Silvia Pastorekova
Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.
FEBS letters 2009;583(22):3563-8.
2009: Alessio Innocenti; Silvia Pastorekova; Jaromir Pastorek; Andrea Scozzafava; Giuseppina De Simone; Claudiu T Supuran
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Bioorganic & medicinal chemistry letters 2009;19(20):5825-8.
2009: vincenzo alterio; Mika Hilvo; Anna Di Fiore; Claudiu T Supuran; Peiwen Pan; Seppo Parkkila; Andrea Scaloni; Jaromir Pastorek; Silvia Pastorekova; Carlo Pedone; Andrea Scozzafava; Simona Maria Monti; Giuseppina De simone
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16233-8.
2009: Katariina Korhonen; Anna-Kaisa Parkkila; Pauli Helen; Ritva Välimäki; Silvia Pastorekova; Jaromir Pastorek; Seppo Parkkila; Hannu Haapasalo
Carbonic anhydrases in meningiomas: association of endothelial carbonic anhydrase II with aggressive tumor features.
Journal of neurosurgery 2009;111(3):472-7.
2009: Martina Labudova; Jana Tomaskova; Ludovit Skultety; Jaromir Pastorek; Silvia Pastorekova
The nucleoprotein of lymphocytic choriomeningitis virus facilitates spread of persistent infection through stabilization of the keratin network.
Journal of virology 2009;83(16):7842-9.
2009: Juraj Kopacek; Karol Ondrias; Barbora Sedlakova; Jana Tomaskova; Lucia Zahradnikova; Jan Sedlak; Zdena Sulova; Alexandra Zahradnikova; Jaromir Pastorek; Olga Krizanova
Type 2 IP(3) receptors are involved in uranyl acetate induced apoptosis in HEK 293 cells.
Toxicology 2009;262(1):73-9.
2009: Martina Takacova; Tereza Holotnakova; Jan Vondracek; Miroslav Machala; Katerina Pencikova; Katarina Gradin; Lorenz Poellinger; Jaromir Pastorek; Silvia Pastorekova; Juraj Kopacek
Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX.
The Biochemical journal 2009;419(2):419-25.
2008: Anna Ohradanova; Katarina Gradin; Monika Barathova; Miriam Zatovicova; T Holotnakova; Juraj Kopacek; Seppo Parkkila; L Poellinger; Silvia Pastorekova; Jaromir Pastorek
Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.
British journal of cancer 2008;99(8):1348-56.
2008: Mika Hilvo; Lina Baranauskiene; Anna Maria Salzano; Andrea Scaloni; Daumantas Matulis; Alessio Innocenti; Andrea Scozzafava; Simona Maria Monti; Anna Di Fiore; Giuseppina De Simone; Mikaela Lindfors; Janne Jänis; Jarkko Valjakka; Silvia Pastoreková; Jaromir Pastorek; Markku S Kulomaa; Henri R Nordlund; Claudiu T Supuran; Seppo Parkkila
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
The Journal of biological chemistry 2008;283(41):27799-809.
2008: Adriana Gibadulinova; Ingrid Oveckova; Seppo Parkkila; Silvia Pastorekova; Jaromir Pastorek
Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein.
Oncology reports 2008;20(2):391-6.
2008: Jana Tomaskova; Martina Labudova; Juraj Kopacek; Silvia Pastorekova; Jaromir Pastorek
Molecular characterization of the genes coding for glycoprotein and L protein of lymphocytic choriomeningitis virus strain MX.
Virus genes 2008;37(1):31-8.
2008: Silvia Pastorekova; Peter J Ratcliffe; Jaromir Pastorek
Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia.
BJU international 2008;101 Suppl 4():8-15.
2008: Tereza Holotnakova; Attila Ziegelhoffer; Anna Ohradanova; Alzbeta Hulikova; Marie Novakova; Juraj Kopacek; Jaromir Pastorek; Silvia Pastorekova
Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes.
Pflügers Archiv : European journal of physiology 2008;456(2):323-37.
2008: Joonas Haapasalo; Mika Hilvo; Kristiina Nordfors; Hannu Haapasalo; Seppo Parkkila; Alise Hyrskyluoto; Immo Rantala; Abdul Waheed; William S Sly; Silvia Pastorekova; Jaromir Pastorek; Anna-Kaisa Parkkila
Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas.
Neuro-oncology 2008;10(2):131-8.
2008: Silvia Pastorekova; Daniela Vullo; Isao Nishimori; Andrea Scozzafava; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
Bioorganic & medicinal chemistry 2008;16(7):3530-6.
2008: Katarina Polcicova; Zuzana Hrabovska; Jela Mistrikova; Jana Tomaskova; Jaromir Pastorek; Silvia Pastorekova; Juraj Kopacek
Up-regulation of Murid herpesvirus 4 ORF50 by hypoxia: possible implication for virus reactivation from latency.
Virus research 2008;132(1-2):257-62.
2008: Monika Barathova; Martina Takacova; T Holotnakova; A Gibadulinova; Anna Ohradanova; Miriam Zatovicova; A Hulikova; Juraj Kopacek; S Parkkila; Claudiu T Supuran; Silvia Pastorekova; Jaromir Pastorek
Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype.
British journal of cancer 2008;98(1):129-36.
2008: Silvia Pastorekova; Miriam Zatovicova; Jaromir Pastorek
Cancer-associated carbonic anhydrases and their inhibition.
Current pharmaceutical design 2008;14(7):685-98.
2008: Seppo Parkkila; Pei-Wen Pan; Aoife Ward; Adriana Gibadulinova; Ingrid Oveckova; Silvia Pastorekova; Jaromir Pastorek; Alejandra Rodriguez Martinez; Henrik O Helin; Jorma Isola
The calcium-binding protein S100P in normal and malignant human tissues.
BMC clinical pathology 2008;8():2.
2008: Sally Järvelä; Seppo Parkkila; Helena Bragge; Marketta Kähkönen; Anna-Kaisa Parkkila; Ylermi Soini; Silvia Pastorekova; Jaromir Pastorek; Hannu Haapasalo
Carbonic anhydrase IX in oligodendroglial brain tumors.
BMC cancer 2008;8():1.
2007: Martina Takacova; Monika Barathova; Alzbeta Hulikova; Anna Ohradanova; Juraj Kopacek; Seppo Parkkila; Jaromir Pastorek; Silvia Pastorekova; Miriam Zatovicova
Hypoxia-inducible expression of the mouse carbonic anhydrase IX demonstrated by new monoclonal antibodies.
International journal of oncology 2007;31(5):1103-10.
2007: Anna Ohradanova; Daniela Vullo; Juraj Kopacek; Claudia Temperini; Tatiana Betakova; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.
The Biochemical journal 2007;407(1):61-7.
2007: Anssi M Niemelä; Piritta Hynninen; Jukka-Pekka Mecklin; Teijo Kuopio; Antti Kokko; Lauri Aaltonen; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Torben F Orntoft; Mogens Kruhøffer; Hannu Haapasalo; Seppo Parkkila; Aarre Kivelä
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(9):1760-6.
2007: Alessio Innocenti; Daniela Vullo; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Isao Nishimori; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
Bioorganic & medicinal chemistry letters 2007;17(6):1532-7.
2007: Syed A Hussain; Raji Ganesan; Gary Reynolds; L Gross; A Stevens; Jaromir Pastorek; Paul G Murray; B Perunovic; M S Anwar; Lucinda Billingham; Nicholas James; David Spooner; Christopher J Poole; D W Rea; Daniel H Palmer
Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer.
British journal of cancer 2007;96(1):104-9.
2007: Silvia Pastorekova; Juraj Kopacek; Jaromir Pastorek
Carbonic anhydrase inhibitors and the management of cancer.
Current topics in medicinal chemistry 2007;7(9):865-78.
2006: Piritta Hynninen; Liisa Vaskivuo; Juha Saarnio; Hannu Haapasalo; Jyrki J. Kivelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Ulla Puistola; Seppo Parkkila
Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours.
Histopathology 2006;49(6):594-602.
2006: Thambi Dorai; Ihor S Sawczuk; Jaromir Pastorek; Peter H Wiernik; Janice P Dutcher
Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: proposal of a unified hypothesis.
Cancer investigation 2006;24(8):754-79.
2006: Robert Ihnatko; Miroslav Kubes; Martina Takacova; Olga Sedlakova; Jan Sedlak; Jaromir Pastorek; Juraj Kopacek; Silvia Pastorekova
Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia.
International journal of oncology 2006;29(4):1025-33.
2006: Peiwen Pan; Mari Leppilampi; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila
Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice.
The Journal of physiology 2006;571(Pt 2):319-27.
2006: Joonas A Haapasalo; Kristiina M Nordfors; Mika Hilvo; Immo J Rantala; Ylermi Soini; Anna-Kaisa Parkkila; Silvia Pastoreková; Jaromir Pastorek; Seppo Parkkila; Hannu Haapasalo
Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):473-7.
2006: Heini Kallio; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Susanna Mannisto; Markku Heikinheimo; Seppo Parkkila
Expression of carbonic anhydrases IX and XII during mouse embryonic development.
BMC developmental biology 2006;6():22.
2006: M Labudová; J Tomásková; Milota Kaluzová; Jaromir Pastorek; Silvia Pastoreková
Lymphocytic choriomeningitis virus mx strain does not induce the expression of tumor-associated carbonic anhydrase IX in persistently infected HeLa cells.
Acta virologica 2006;50(1):53-8.
2005: Thambi Dorai; Ihor S Sawczuk; Jaromir Pastorek; Peter H Wiernik; Janice P Dutcher
The role of carbonic anhydrase IX overexpression in kidney cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(18):2935-47.
2005: Miriam Zatovicova; O Sedlakova; E Svastova; Anna Ohradanova; Fedor Ciampor; J Arribas; Jaromir Pastorek; Silvia Pastorekova
Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17.
British journal of cancer 2005;93(11):1267-76.
2005: Magdalena Kowalewska; Jakub Radziszewski; Jadwiga Kulik; Monika Barathova; Anna Nasierowska-Guttmajer; Mariusz Bidziński; Jaromir Pastorek; Silvia Pastorekova; Janusz A Siedlecki
Detection of carbonic anhydrase 9-expressing tumor cells in the lymph nodes of vulvar carcinoma patients by RT-PCR.
International journal of cancer. Journal international du cancer 2005;116(6):957-62.
2005: Mari Leppilampi; Tuomo J Karttunen; Jyrki J. Kivelä; Marta Gut; Silvia Pastoreková; Jaromir Pastorek; Seppo Parkkila
Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C.
Transgenic research 2005;14(5):655-63.
2005: Adriana Gibadulinová; Monika Baráthová; Juraj Kopácek; Alzbeta Hulíková; Silvia Pastoreková; Richard Kettmann; Jaromir Pastorek
Expression of S100P protein correlates with and contributes to the tumorigenic capacity of HeLa cervical carcinoma cells.
Oncology reports 2005;14(2):575-82.
2005: Alessandro Cecchi; Alzbeta Hulikova; Jaromir Pastorek; Silvia Pastoreková; Andrea Scozzafava; Jean-Yves Winum; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Journal of medicinal chemistry 2005;48(15):4834-41.
2005: Silvia Pastorekova; Daniela Vullo; Angela Casini; Andrea Scozzafava; Jaromir Pastorek; Isao Nishimori; Claudiu T Supuran
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):211-7.
2005: Juraj Kopacek; Monika Barathova; Franck Dequiedt; Janka Sepelakova; Richard Kettmann; Jaromir Pastorek; Silvia Pastorekova
MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX.
Biochimica et biophysica acta 2005;1729(1):41-9.
2005: Antti-J Kivela; Seppo Parkkila; Juha Saarnio; Tuomo J Karttunen; Jyrki Kivela; Anna-Kaisa Parkkila; Maria Bartosova; Vojtech Mucha; Michal Novak; Abdul Waheed; William S Sly; Hannu J Rajaniemi; Silvia Pastorekova; Jaromir Pastorek
Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.
World journal of gastroenterology : WJG 2005;11(17):2616-25.
2005: Lydia Jakubicková; Zuzana Biesová; Silvia Pastoreková; Richard Kettmann; Jaromir Pastorek
Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines.
International journal of oncology 2005;26(4):1121-7.
2005: Daniela Vullo; Alessio Innocenti; Isao Nishimori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastoreková; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
Bioorganic & medicinal chemistry letters 2005;15(4):963-9.
2005: Jean-Yves Winum; Silvia Pastorekova; Lydia Jakubickova; Jean-Louis Montero; Andrea Scozzafava; Jaromir Pastorek; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Bioorganic & medicinal chemistry letters 2005;15(3):579-84.
2005: L Jakubícková; M Baráthová; Silvia Pastoreková; Jaromir Pastorek; Adriana Gibadulinová
Expression of S100P gene in cervical carcinoma cells is independent of E7 human papillomavirus oncogene.
Acta virologica 2005;49(2):133-7.
2004: Eliska Svastová; Alzbeta Hulíková; Monika Rafajová; Miriam Zat'ovicová; Adriana Gibadulinová; Angela Casini; Alessandro Cecchi; Andrea Scozzafava; Claudiu T Supuran; Jaromir Pastorek; Silvia Pastoreková
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
FEBS letters 2004;577(3):439-45.
2004: Piritta Hynninen; Jonna M Hämäläinen; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Eija Tomas; Pertti Kirkinen; Seppo Parkkila
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs.
Reproductive biology and endocrinology : RB&E 2004;2():73.
2004: Mika Hilvo; Monika Rafajová; Silvia Pastoreková; Jaromir Pastorek; Seppo Parkkila
Expression of carbonic anhydrase IX in mouse tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(10):1313-22.
2004: Janka Nagyová; Jaromir Pastorek; Juraj Kopácek
Identification of the critical cis-acting elements in the promoter of the mouse Prnd gene coding for Doppel protein.
Biochimica et biophysica acta 2004;1679(3):288-93.
2004: Silvia Pastorekova; Seppo Parkkila; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):199-229.
2004: Daniela Vullo; Andrea Scozzafava; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Bioorganic & medicinal chemistry letters 2004;14(9):2351-6.
2004: Michael I Koukourakis; Alexandra Giatromanolaki; Efthimios Sivridis; Jaromir Pastorek; Ilias Karapantzos; Kevin C Gatter; Adrian L Harris
Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.
International journal of radiation oncology, biology, physics 2004;59(1):67-71.
2004: Syed A Hussain; Daniel H Palmer; Raji Ganesan; Louise Hiller; John Gregory; Paul G Murray; Jaromir Pastorek; Lawrence Young; Nicholas James
Carbonic anhydrase IX, a marker of hypoxia: correlation with clinical outcome in transitional cell carcinoma of the bladder.
Oncology reports 2004;11(5):1005-10.
2004: Monika Rafajová; Miriam Zatovicová; Richard Kettmann; Jaromir Pastorek; Silvia Pastoreková
Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells.
International journal of oncology 2004;24(4):995-1004.
2004: Silvia Pastorekova; Angela Casini; Andrea Scozzafava; Daniela Vullo; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(4):869-73.
2004: Kamil Pohlodek; Stefan Galbavý; M Bartosová; Vojtech Mucha; Karol Holomán; Jaromir Pastorek; Silvia Pastoreková
Semi-quantitative RT-PCR assessment of molecular markers in breast large-core needle biopsies.
Neoplasma 2004;51(6):415-21.
2003: Miriam Zat'ovicová; Kvetoslava Tarábková; Eliska Svastová; Adriana Gibadulinová; Vojtech Mucha; Lýdia Jakubícková; Zuzana Biesová; Monika Rafajová; Marta Ortova Gut; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; Willam S Sly; Ivan Horak; Jaromir Pastorek; Silvia Pastoreková
Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX.
Journal of immunological methods 2003;282(1-2):117-34.
2003: Eliska Svastová; Norbert Zilka; Miriam Zat'ovicová; Adriana Gibadulinová; Fedor Ciampor; Jaromir Pastorek; Silvia Pastoreková
Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin.
Experimental cell research 2003;290(2):332-45.
2003: Daniela Vullo; Marco Franchi; Enzo Gallori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):403-6.
2003: Ladislav Tomes; Ethan D Emberley; Yulian Niu; Sandra Troup; Jaromir Pastorek; Karen Strange; Adrian Harris; Peter H Watson
Necrosis and hypoxia in invasive breast carcinoma.
Breast cancer research and treatment 2003;81(1):61-9.
2003: Marco Franchi; Daniela Vullo; Enzo Gallori; Jaromir Pastorek; Antonella Russo; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):333-8.
2003: Adrián Chrastina; Jan Závada; Seppo Parkkila; Stefan Kaluz; Milota Kaluzová; Július Rajcáni; Jaromir Pastorek; Silvia Pastoreková
Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma.
International journal of cancer. Journal international du cancer 2003;105(6):873-81.
2003: Mari Leppilampi; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila
Carbonic anhydrase isozymes IX and XII in gastric tumors.
World journal of gastroenterology : WJG 2003;9(7):1398-403.
2003: Monica Ilies; Daniela Vullo; Jaromir Pastorek; Andrea Scozzafava; Marc A Ilies; Miron T Caproiu; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Journal of medicinal chemistry 2003;46(11):2187-96.
2003: Daniela Vullo; Marco Franchi; Enzo Gallori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2003;13(6):1005-9.
2003: Daniel E B Swinson; J Louise Jones; Donna Richardson; Charles C Wykoff; Helen Turley; Jaromir Pastorek; Nick Taub; Adrian L Harris; Kenneth J O'Byrne
Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(3):473-82.
2003: Adrián Chrastina; Silvia Pastoreková; Jaromir Pastorek
Immunotargeting of human cervical carcinoma xenograft expressing CA IX tumor-associated antigen by 125I-labeled M75 monoclonal antibody.
Neoplasma 2003;50(1):13-21.
2002: Marta Gut; Seppo Parkkila; Zdeòka Vernerová; Elvira Rohde; Jan Závada; Michael Höcker; Jaromir Pastorek; Tuomo J Karttunen; Adriana Gibadulinová; Zuzana Závadová; Klaus-Peter Knobeloch; Bertram Wiedenmann; Jan Svoboda; Ivan Horak; Silvia Pastoreková
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9.
Gastroenterology 2002;123(6):1889-903.
2002: Stefan Kaluz; Milota Kaluzová; Adrián Chrastina; Peggy L Olive; Silvia Pastoreková; Jaromir Pastorek; Michael I Lerman; Eric J Stanbridge
Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase.
Cancer research 2002;62(15):4469-77.
2002: Mária Bartosová; Seppo Parkkila; Kamil Pohlodek; Tuomo J Karttunen; Stefan Galbavý; Vojtech Mucha; Adrian L Harris; Jaromir Pastorek; Silvia Pastoreková
Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2.
The Journal of pathology 2002;197(3):314-21.
2002: Mari Leppilampi; Pirjo Koistinen; Eeva-Riitta Savolainen; Jokke Hannuksela; Anna-Kaisa Parkkila; Onni Niemelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila; Hannu J Rajaniemi
The expression of carbonic anhydrase II in hematological malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2240-5.
2002: Kevin J Turner; Jeremy P Crew; Charles C Wykoff; Peter H Watson; Richard Poulsom; Jaromir Pastorek; Peter J Ratcliffe; David W Cranston; Adrian L Harris
The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer.
British journal of cancer 2002;86(8):1276-82.
2002: Dagmar Eleveld-Trancíková; Pavol Kúdela; Vladimir Majerciak; Mária Regendová; Vladimír Zelník; Jaromir Pastorek; Silvia Pastoreková; Jozef Bízik
Suppression subtractive hybridisation to isolate differentially expressed genes involved in invasiveness of melanoma cell line cultured under different conditions.
International journal of oncology 2002;20(3):501-8.
2001: Michael I Koukourakis; Alexandra Giatromanolaki; Efthimios Sivridis; K Simopoulos; Jaromir Pastorek; Charles C Wykoff; Kevin C Gatter; Adrian L Harris
Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3399-403.
2001: Alexandra Giatromanolaki; Michael I Koukourakis; Efthimios Sivridis; Jaromir Pastorek; Charles C Wykoff; Kevin C Gatter; Adrian L Harris
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.
Cancer research 2001;61(21):7992-8.
2001: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Silvia Pastoreková; Kari Haukipuro; Jaromir Pastorek; Tatu Juvonen; Tuomo J Karttunen
Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours.
Journal of hepatology 2001;35(5):643-9.
2001: Milota Kaluzová; Silvia Pastoreková; Eliska Svastová; Jaromir Pastorek; Eric J Stanbridge; Stefan Kaluz
Characterization of the MN/CA 9 promoter proximal region: a role for specificity protein (SP) and activator protein 1 (AP1) factors.
The Biochemical journal 2001;359(Pt 3):669-77.
2001: A J Kivela; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; T S Parkkila; Hannu J Rajaniemi
Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors.
Digestive diseases and sciences 2001;46(10):2179-86.
2001: Stephen K Chia; Charles C Wykoff; Peter H Watson; C Han; Russell Leek; Jaromir Pastorek; Kevin C Gatter; Peter J Ratcliffe; Adrian L Harris
Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(16):3660-8.
2001: Nigel J P Beasley; Charles C Wykoff; Peter H Watson; Russell Leek; Helen Turley; Kevin Gatter; Jaromir Pastorek; Graham J Cox; Peter J Ratcliffe; Adrian L Harris
Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density.
Cancer research 2001;61(13):5262-7.
2001: P Karhumaa; Kari Kaunisto; Seppo Parkkila; Abdul Waheed; Silvia Pastoreková; Jaromir Pastorek; William S Sly; Hannu J Rajaniemi
Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts.
Molecular human reproduction 2001;7(7):611-6.
2001: Charles C Wykoff; Nigel J P Beasley; Peter H Watson; Leticia Campo; Stephen K Chia; R English; Jaromir Pastorek; W S Sly; Peter J Ratcliffe; Adrian L Harris
Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast.
The American journal of pathology 2001;158(3):1011-9.
2000: Charles C Wykoff; Nigel J P Beasley; Peter H Watson; Kevin J Turner; Jaromir Pastorek; Amen Sibtain; George D Wilson; Helen Turley; Kate L Talks; Patrick H Maxwell; Christopher W Pugh; Peter J Ratcliffe; Adrian L Harris
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Cancer research 2000;60(24):7075-83.
2000: Juraj Kopácek; O Rejholcová; D Koptidesová; Fedor Ciampor; F M Rijsewijk; H W Reid; Jaromir Pastorek; Vladimír Zelník
Characterization of RKZ isolate of ovine herpesvirus 1.
Acta virologica 2000;44(6):335-42.
2000: Aarre Kivelä; Seppo Parkkila; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Anna-Kaisa Parkkila; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Hannu J Rajaniemi
Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours.
Histochemistry and cell biology 2000;114(3):197-204.
2000: Jan Závada; Zuzana Závadová; Jaromir Pastorek; Zuzana Biesová; Jan Jezek; Jirí Velek
Human tumour-associated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion.
British journal of cancer 2000;82(11):1808-13.
2000: Milota Kaluzová; Silvia Pastoreková; Jaromir Pastorek; Stefan Kaluz
P53 tumour suppressor modulates transcription of the TATA-less gene coding for the tumour-associated carbonic anhydrase MN/CA IX in MaTu cells.
Biochimica et biophysica acta 2000;1491(1-3):20-6.
2000: Seppo Parkkila; Hannu J Rajaniemi; Anna-Kaisa Parkkila; Jyrki Kivela; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; William S Sly
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2220-4.
2000: Juraj Kopácek; L Kl'ucár; D Koptidesová; Ján Turna; Jaromir Pastorek; Vladimír Zelník
Nucleotide sequence of the gene encoding the major capsid protein of herpesvirus of turkeys.
Virus genes 2000;20(2):107-15.
1999: Stefan Kaluz; Milota Kaluzová; R Opavský; Silvia Pastoreková; Adriana Gibadulinová; Franck Dequiedt; Richard Kettmann; Jaromir Pastorek
Transcriptional regulation of the MN/CA 9 gene coding for the tumor-associated carbonic anhydrase IX. Identification and characterization of a proximal silencer element.
The Journal of biological chemistry 1999;274(46):32588-95.
1999: L Reiserová; Milota Kaluzová; Stefan Kaluz; A C Willis; Jan Závada; E Závodská; Zuzana Závadová; Fedor Ciampor; Jaromir Pastorek; Silvia Pastoreková
Identification of MaTu-MX agent as a new strain of lymphocytic choriomeningitis virus (LCMV) and serological indication of horizontal spread of LCMV in human population.
Virology 1999;257(1):73-83.
1999: Vladimír Zelník; Vladimir Majerciak; D Szabová; H Geerligs; Juraj Kopácek; L J Ross; Jaromir Pastorek
Glycoprotein gD of MDV lacks functions typical for alpha-herpesvirus gD homologues.
Acta virologica 1999;43(2-3):164-8.
1999: Stefan Kaluz; Milota Kaluzová; Jaromir Pastorek
Inverse PCR-generated internally deleted constructs for direct characterization of promoter regulatory regions.
BioTechniques 1999;26(3):446-50.
1999: J Lieskovská; R Opavský; L Záciková; M Glasová; Jaromir Pastorek; Silvia Pastoreková
Study of in vitro conditions modulating expression of MN/CA IX protein in human cell lines derived from cervical carcinoma.
Neoplasma 1999;46(1):17-24.
1998: Adriana Gibadulinová; Vladimír Zelník; L Reiserová; E Závodská; Miriam Zatovicová; Fedor Ciampor; Silvia Pastoreková; Jaromir Pastorek
Sequence and characterisation of the Z gene encoding ring finger protein of the lymphocytic choriomeningitis virus MX strain.
Acta virologica 1998;42(6):369-74.
1998: J Lieskovská; M Kaluzova; R Opavsky; Stefan Kaluz; Jaromir Pastorek; Richard Kettmann; Silvia Pastoreková
Up-regulation of p53 by antisense expression of HPV18 E6 oncogene does not influence the level of MN/CA IX tumor-associated protein in HeLa cervical carcinoma cells.
International journal of oncology 1998;13(5):1081-6.
1998: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Kari Haukipuro; Silvia Pastoreková; Jaromir Pastorek; MI Kairaluoma; Tuomo J Karttunen
Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation.
The American journal of pathology 1998;153(1):279-85.
1998: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; M C Casey; X Y Zhou; Silvia Pastoreková; Jaromir Pastorek; Tuomo J Karttunen; Kari Haukipuro; MI Kairaluoma; William S Sly
Immunohistochemistry of carbonic anhydrase isozyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferative capacity.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(4):497-504.
1997: Silvia Pastoreková; Seppo Parkkila; Anna-Kaisa Parkkila; R Opavský; Vladimír Zelník; Juha Saarnio; Jaromir Pastorek
Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts.
Gastroenterology 1997;112(2):398-408.
1997: Juraj Kopácek; Vladimír Zelník; R Brasseur; D Koptidesová; O Rejholcová; Silvia Pastoreková; Jaromir Pastorek
Herpesvirus of turkeys homologue of HSV VP16 is structurally related to varicella zoster virus trans-inducing protein encoded by ORF 10.
Virus genes 1997;15(1):45-52.
1996: C A Brewer; S Y Liao; Sharon P Wilczynski; S Pastorekova; Jaromir Pastorek; J Zavada; T Kurosaki; Alberto Manetta; Michael L Berman; Philip J DiSaia; Eric J Stanbridge
A study of biomarkers in cervical carcinoma and clinical correlation of the novel biomarker MN.
Gynecologic oncology 1996;63(3):337-44.
1996: P Kabát; M Tristem; R Opavský; Jaromir Pastorek
Human endogenous retrovirus HC2 is a new member of the S71 retroviral subgroup with a full-length pol gene.
Virology 1996;226(1):83-94.
1996: R Opavský; Silvia Pastoreková; Vladimír Zelník; Adriana Gibadulinová; Eric J Stanbridge; J Závada; Richard Kettmann; Jaromir Pastorek
Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships.
Genomics 1996;33(3):480-7.
1995: Milota Kaluzová; Stefan Kaluz; O Kozuch; Jaromir Pastorek; Milan Labuda
Nucleotide sequence of the protein E gene of the tick-borne encephalitis virus strain 595 isolated in Slovakia.
Acta virologica 1995;39(3):165-9.
1995: D Koptidesová; Juraj Kopácek; Vladimír Zelník; N L Ross; Silvia Pastoreková; Jaromir Pastorek
Identification and characterization of a cDNA clone derived from the Marek's disease tumour cell line RPL1 encoding a homologue of alpha-transinducing factor (VP16) of HSV-1.
Archives of virology 1995;140(2):355-62.
1994: Jaromir Pastorek; Silvia Pastoreková; I Callebaut; J P Mornon; Vladimír Zelník; R Opavský; M Zat'ovicová; S Liao; D Portetelle; Eric J Stanbridge
Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment.
Oncogene 1994;9(10):2877-88.
1994: Vladimír Zelník; N L Ross; Jaromir Pastorek
Characterization of proteins encoded by the short unique region of herpesvirus of turkeys by in vitro expression.
The Journal of general virology 1994;75 ( Pt 10)():2747-53.
1994: S Y Liao; C Brewer; J Závada; Jaromir Pastorek; S Pastorekova; Alberto Manetta; Michael L Berman; Philip J DiSaia; Eric J Stanbridge
Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas.
The American journal of pathology 1994;145(3):598-609.
1994: D S Li; Jaromir Pastorek; Vladimír Zelník; G D Smith; L J Ross
Identification of novel transcripts complementary to the Marek's disease virus homologue of the ICP4 gene of herpes simplex virus.
The Journal of general virology 1994;75 ( Pt 7)():1713-22.
1994: Milota Kaluzová; E Elecková; E Zuffová; Jaromir Pastorek; Stefan Kaluz; O Kozuch; Milan Labuda
Reverted virulence of attenuated tick-borne encephalitis virus mutant is not accompanied with the changes in deduced viral envelope protein amino acid sequence.
Acta virologica 1994;38(3):133-40.
1993: Vladimír Zelník; R Darteil; J C Audonnet; G D Smith; M Riviere; Jaromir Pastorek; L J Ross
The complete sequence and gene organization of the short unique region of herpesvirus of turkeys.
The Journal of general virology 1993;74 ( Pt 10)():2151-62.
1993: J Závada; Z Závadová; Silvia Pastoreková; Fedor Ciampor; Jaromir Pastorek; Vladimír Zelník
Expression of MaTu-MN protein in human tumor cultures and in clinical specimens.
International journal of cancer. Journal international du cancer 1993;54(2):268-74.
1993: Juraj Kopácek; L J Ross; Vladimír Zelník; Jaromir Pastorek
The 132 bp repeats are present in RNA transcripts from 1.8 kb gene family of Marek disease virus-transformed cells.
Acta virologica 1993;37(2-3):191-5.
1993: L J Ross; M M Binns; P Tyers; Jaromir Pastorek; V Zelnik; S Scott
Construction and properties of a turkey herpesvirus recombinant expressing the Marek's disease virus homologue of glycoprotein B of herpes simplex virus.
The Journal of general virology 1993;74 ( Pt 3)():371-7.
1992: Otakar Kúdela; Vladimír Zelník; Stefan Kaluz; Jaromir Pastorek
The use of consensus sequence for amplification and oriented cloning of human alpha interferon genes.
Acta virologica 1992;36(5):488-90.
1991: L J Ross; M M Binns; Jaromir Pastorek
DNA sequence and organization of genes in a 5.5 kbp EcoRI fragment mapping in the short unique segment of Marek's disease virus (strain RB1B).
The Journal of general virology 1991;72 ( Pt 4)():949-54.
1989: Magda Lukácová; R Brezina; S Schramek; Jaromir Pastorek
Chemical composition of phase I Coxiella burnetii soluble antigen prepared by trichloroacetic acid extraction.
Acta virologica 1989;33(1):75-80.
1989: Jaromir Pastorek; K Marcinka
Effects of pH and ionic strength on precipitation of phytopathogenic viruses by polyethylene glycol.
Acta virologica 1989;33(1):68-74.
1987: Jaromir Pastorek; K Marcinka
Effect of Mg2+ ions on the in vitro translation of red clover mottle virus M RNA.
Acta virologica 1987;31(6):504-5.