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Silvia Pastorekova

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Uma Shankavaram; Martina Takacova; Henri J Timmers; Arthur S Tischler; Hana Turkova; Silvia Pastorekova; James F Powers; Jennifer Barb; Bora E Baysal; Kevin Camphausen; Ronald de Krijger; Abdel G Elkahloun; Stephanie M J Fliedner; David Gius; Thanh T Huynh; Hendrik Lehnert; W Marston Linehan; Joey C Matro; Peter J Munson; Karel Pacak
Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.
Aarre Kivelä; Aija Knuuttila; Jaromir Pastorek; Silvia Pastorekova; Jari Räsänen; Juha Saarnio; Kaisa Salmenkivi; Jarmo A Salo; Eero I T Sihvo; William S Sly; Abdul Waheed; Seppo Parkkila
Carbonic anhydrase IX in malignant pleural mesotheliomas: a potential target for anti-cancer therapy.
Eliska Svastova; Silvia Pastorekova
Carbonic anhydrase IX: a hypoxia-controlled "catalyst" of cell migration.

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All Publications

2013: Uma Shankavaram; Martina Takacova; Henri J Timmers; Arthur S Tischler; Hana Turkova; Silvia Pastorekova; James F Powers; Jennifer Barb; Bora E Baysal; Kevin Camphausen; Ronald de Krijger; Abdel G Elkahloun; Stephanie M J Fliedner; David Gius; Thanh T Huynh; Hendrik Lehnert; W Marston Linehan; Joey C Matro; Peter J Munson; Karel Pacak
Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.
Neoplasia (New York, N.Y.) 2013;15(4):435-47.
2013: Aarre Kivelä; Aija Knuuttila; Jaromir Pastorek; Silvia Pastorekova; Jari Räsänen; Juha Saarnio; Kaisa Salmenkivi; Jarmo A Salo; Eero I T Sihvo; William S Sly; Abdul Waheed; Seppo Parkkila
Carbonic anhydrase IX in malignant pleural mesotheliomas: a potential target for anti-cancer therapy.
Bioorganic & medicinal chemistry 2013;21(6):1483-8.
2013: Eliska Svastova; Silvia Pastorekova
Carbonic anhydrase IX: a hypoxia-controlled "catalyst" of cell migration.
Cell adhesion & migration 2013;7(2):226-31.
2013: Peter Radvak; Marko Repic; Hynek Strnad; Eliska Svastova; Martina Takacova; Lucia Csaderova; Jaromir Pastorek; Silvia Pastorekova; Juraj Kopacek
Suppression of carbonic anhydrase IX leads to aberrant focal adhesion and decreased invasion of tumor cells.
Oncology reports 2013;29(3):1147-53.
2013: Pasquale Buanne; Lucia Csaderova; Giuseppina De simone; Corrado Garbi; Donatella Montanaro; Francesca Monteleone; Simona Maria Monti; Silvia Pastorekova; Giovanni Renzone; annamaria sandomenico; Andrea Scaloni; Claudiu T Supuran; Giancarlo Troncone; Monica Vitale; Marina Accardo; Miriam Zatovicova; Nicola Zambrano
Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.
Journal of proteome research 2013;12(1):282-92.
2013: Mario Pérez-Sayáns; Gayoso-Diz Pilar; José Manuel Suárez-Peñaranda; Claudiu T Supuran; Francisco Barros-Angueira; José Manuel Gándara Rey; Silvia Pastorekova; Abel García García
The role of carbonic anhydrase IX in hypoxia control in OSCC.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2013;42(1):1-8.
2012: Mario Pérez-Sayáns; Gayoso-Diz Pilar; José Manuel Suárez-Peñaranda; Claudiu T Supuran; Francisco Barros-Angueira; José Manuel Gándara Rey; Silvia Pastorekova; Abel García García
Expression of CA-IX is associated with advanced stage tumors and poor survival in oral squamous cell carcinoma patients.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2012;41(9):667-74.
2012: Anna Ohradanova; Jaromir Pastorek; Silvia Pastorekova; Daniela Vullo; Gert Wörheide; Daniel J Jackson; Claudiu T Supuran
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
Bioorganic & medicinal chemistry 2012;20(4):1403-10.
2012: Piritta Hynninen; Seppo Parkkila; Jaromir Pastorek; Silvia Pastorekova; William S Sly; Heini Huhtala; Abdul Waheed; Eija Tomas
Carbonic anhydrase isozymes II, IX, and XII in uterine tumors.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2012;120(2):117-29.
2012: Anna Ohradanova; Jaromir Pastorek; Silvia Pastorekova; Daniela Vullo; Gert Wörheide; Daniel J Jackson; Claudiu T Supuran
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.
Bioorganic & medicinal chemistry letters 2012;22(3):1314-6.
2012: Pei-wen Pan; Anna-Kaisa Parkkila; Salla Autio; Hannu Haapasalo; Mika Hilvo; Jaromir Pastorek; Silvia Pastorekova; Raija Sormunen; Seppo Parkkila
Brain phenotype of carbonic anhydrase IX-deficient mice.
Transgenic research 2012;21(1):163-76.
2012: Eliska Svastova; Wojciech Witarski; Miriam Zatovicova; Lucia Skvarkova; Monika Barathova; Lucia Csaderova; Alzbeta Hulikova; Juraj Kopacek; Ivan Kosik; Jaromir Pastorek; Silvia Pastorekova
Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.
The Journal of biological chemistry 2012;287(5):3392-402.
2011: Jana Tomaskova; Silvia Pastorekova; Juraj Kopacek; Martina Labudova; Katarina Laposova; Lubomira Lukacikova; Ingrid Oveckova; Jaromir Pastorek
Hypoxia induces the gene expression and extracellular transmission of persistent lymphocytic choriomeningitis virus.
Journal of virology 2011;85(24):13069-76.
2011: Karol Ondrias; Silvia Pastorekova; Marta Sirova; Juraj Kopacek; Martina Labudova; Lubomira Lencesova; Olga Krizanova
Apoptosis induced clustering of IP(3)R1 in nuclei of non-differentiated PC12 cells.
Journal of cellular physiology 2011;226(12):3147-55.
2011: Veronika Tothova; Jorma Isola; Juraj Kopacek; Seppo Parkkila; Jaromir Pastorek; Silvia Pastorekova; Adriana Gibadulinova
Glucocorticoid receptor-mediated transcriptional activation of S100P gene coding for cancer-related calcium-binding protein.
Journal of cellular biochemistry 2011;112(11):3373-84.
2011: Adriana Gibadulinova; Jaromir Pastorek; Veronika Tothova; Silvia Pastorekova
Transcriptional regulation and functional implication of S100P in cancer.
Amino acids 2011;41(4):885-92.
2011: Sander van den Driesche; Wojciech Witarski; Silvia Pastorekova; Heimo Breiteneder; Christine Hafner; Michiel J Vellekoop
A label-free indicator for tumor cells based on the CH2-stretch ratio.
The Analyst 2011;136(11):2397-402.
2011: Sona Hudecova; Lubomira Lencesova; Lucia Csaderova; Marta Sirova; Dana Cholujova; Martin Cagala; Juraj Kopacek; Dusan Dobrota; Silvia Pastorekova; Olga Krizanova
Chemically mimicked hypoxia modulates gene expression and protein levels of the sodium calcium exchanger in HEK 293 cell line via HIF-1α.
General physiology and biophysics 2011;30(2):196-206.
2011: Heini Kallio; Anne Kallioniemi; Sami Kilpinen; Eeva Laurila; Pei-wen Pan; Jaromir Pastorek; Silvia Pastorekova; Martti Tolvanen; Vilppu J Tuominen; Jarkko Valjakka; Jorma Isola; Janne Jänis; Seppo Parkkila
Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins.
PloS one 2011;6(11):e27152.
2010: Anupama Chandramouli; Melania Mercado-Pimentel; Anthony Hutchinson; Adriana Gibadulinová; Erik R Olson; Sally Dickinson; Reneé Shañas; Jennifer Davenport; Janae Owens; Achyut K Bhattacharyya; John W Regan; Silvia Pastorekova; Thiruvengadam Arumugam; Craig D Logsdon; Mark A Nelson
The induction of S100p expression by the Prostaglandin E₂ (PGE₂)/EP4 receptor signaling pathway in colon cancer cells.
Cancer biology & therapy 2010;10(10):1056-66.
2010: Ivan Mikula; Mangesh Bhide; Silvia Pastorekova; Ivan Mikula
Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection.
Veterinary immunology and immunopathology 2010;138(1-2):51-9.
2010: Fabio Cianchi; Maria Cristina Vinci; Claudiu T Supuran; Benedetta Peruzzi; Paolo De Giuli; Giuseppe Fasolis; Giuliano Perigli; Silvia Pastorekova; Laura Papucci; Alessandro Pini; Emanuela Masini; Luca Puccetti
Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells.
The Journal of pharmacology and experimental therapeutics 2010;334(3):710-9.
2010: Seppo Parkkila; Jerzy Lasota; Jonathan A Fletcher; Wen-Bin Ou; Antti J Kivelä; Kyösti Nuorva; Anna-Kaisa Parkkila; Jyrki Ollikainen; William S Sly; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; Jorma Isola; Markku Miettinen
Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(5):743-50.
2010: Martina Takacova; Tereza Holotnakova; Monika Barathova; Silvia Pastorekova; Juraj Kopacek; Jaromir Pastorek
Src induces expression of carbonic anhydrase IX via hypoxia-inducible factor 1.
Oncology reports 2010;23(3):869-74.
2010: Miriam Zatovicova; L Jelenska; A Hulikova; L Csaderova; Z Ditte; P Ditte; T Goliasova; Jaromir Pastorek; Silvia Pastorekova
Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain.
Current pharmaceutical design 2010;16(29):3255-63.
2010: Kristiina Nordfors; Joonas A Haapasalo; Miikka Korja; Anssi Niemelä; Jukka Laine; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila; Hannu Haapasalo
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.
BMC cancer 2010;10():148.
2010: Tereza Holotnakova; Lucia Tylkova; Martina Takacova; Juraj Kopacek; Juraj Petrik; Silvia Pastorekova; Jaromir Pastorek
Role of the HBx oncoprotein in carbonic anhydrase 9 induction.
Journal of medical virology 2010;82(1):32-40.
2009: Alzbeta Hulikova; Miriam Zatovicova; Eliska Svastova; Peter Ditte; Robert Brasseur; Richard Kettmann; Claudiu T Supuran; Juraj Kopacek; Jaromir Pastorek; Silvia Pastorekova
Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.
FEBS letters 2009;583(22):3563-8.
2009: Alessio Innocenti; Silvia Pastorekova; Jaromir Pastorek; Andrea Scozzafava; Giuseppina De Simone; Claudiu T Supuran
The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.
Bioorganic & medicinal chemistry letters 2009;19(20):5825-8.
2009: vincenzo alterio; Mika Hilvo; Anna Di Fiore; Claudiu T Supuran; Peiwen Pan; Seppo Parkkila; Andrea Scaloni; Jaromir Pastorek; Silvia Pastorekova; Carlo Pedone; Andrea Scozzafava; Simona Maria Monti; Giuseppina De simone
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16233-8.
2009: Katariina Korhonen; Anna-Kaisa Parkkila; Pauli Helen; Ritva Välimäki; Silvia Pastorekova; Jaromir Pastorek; Seppo Parkkila; Hannu Haapasalo
Carbonic anhydrases in meningiomas: association of endothelial carbonic anhydrase II with aggressive tumor features.
Journal of neurosurgery 2009;111(3):472-7.
2009: Martina Labudova; Jana Tomaskova; Ludovit Skultety; Jaromir Pastorek; Silvia Pastorekova
The nucleoprotein of lymphocytic choriomeningitis virus facilitates spread of persistent infection through stabilization of the keratin network.
Journal of virology 2009;83(16):7842-9.
2009: Francesca Malentacchi; Lisa Simi; Caterina Nannelli; Matteo Andreani; Alberto Janni; Silvia Pastorekova; Claudio Orlando
Alternative splicing variants of carbonic anhydrase IX in human non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2009;64(3):271-6.
2009: Martina Takacova; Tereza Holotnakova; Jan Vondracek; Miroslav Machala; Katerina Pencikova; Katarina Gradin; Lorenz Poellinger; Jaromir Pastorek; Silvia Pastorekova; Juraj Kopacek
Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX.
The Biochemical journal 2009;419(2):419-25.
2009: Peter Ebbesen; Erik O Pettersen; Thomas A Gorr; Gerhard Jobst; Kaye Williams; Jochen Kieninger; Roland H Wenger; Silvia Pastorekova; Ludwig Dubois; Philippe Lambin; Brad G Wouters; Twan van den Beucken; Claudiu T Supuran; Lorenz Poellinger; Peter Ratcliffe; Arvydas Kanopka; Agnes Görlach; Max Gasmann; Adrian L Harris; Patrick Maxwell; Andrea Scozzafava
Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.
Journal of enzyme inhibition and medicinal chemistry 2009;24 Suppl 1():1-39.
2008: Olga Krizanova; Tereza Holotnakova; Dana Jurkovicova; Eva Polakova; Alexandra Zahradnikova; Lubica Lacinova; Richard Kvetnanský; Jaromir Myslivecek; Silvia Pastorekova
Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.
Annals of the New York Academy of Sciences 2008;1148():331-7.
2008: Anna Ohradanova; Katarina Gradin; Monika Barathova; Miriam Zatovicova; T Holotnakova; Juraj Kopacek; Seppo Parkkila; L Poellinger; Silvia Pastorekova; Jaromir Pastorek
Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.
British journal of cancer 2008;99(8):1348-56.
2008: Adriana Gibadulinova; Ingrid Oveckova; Seppo Parkkila; Silvia Pastorekova; Jaromir Pastorek
Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein.
Oncology reports 2008;20(2):391-6.
2008: Jana Tomaskova; Martina Labudova; Juraj Kopacek; Silvia Pastorekova; Jaromir Pastorek
Molecular characterization of the genes coding for glycoprotein and L protein of lymphocytic choriomeningitis virus strain MX.
Virus genes 2008;37(1):31-8.
2008: Silvia Pastorekova; Peter J Ratcliffe; Jaromir Pastorek
Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia.
BJU international 2008;101 Suppl 4():8-15.
2008: Tereza Holotnakova; Attila Ziegelhoffer; Anna Ohradanova; Alzbeta Hulikova; Marie Novakova; Juraj Kopacek; Jaromir Pastorek; Silvia Pastorekova
Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes.
Pflügers Archiv : European journal of physiology 2008;456(2):323-37.
2008: Joonas Haapasalo; Mika Hilvo; Kristiina Nordfors; Hannu Haapasalo; Seppo Parkkila; Alise Hyrskyluoto; Immo Rantala; Abdul Waheed; William S Sly; Silvia Pastorekova; Jaromir Pastorek; Anna-Kaisa Parkkila
Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas.
Neuro-oncology 2008;10(2):131-8.
2008: Silvia Pastorekova; Daniela Vullo; Isao Nishimori; Andrea Scozzafava; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.
Bioorganic & medicinal chemistry 2008;16(7):3530-6.
2008: Katarina Polcicova; Zuzana Hrabovska; Jela Mistrikova; Jana Tomaskova; Jaromir Pastorek; Silvia Pastorekova; Juraj Kopacek
Up-regulation of Murid herpesvirus 4 ORF50 by hypoxia: possible implication for virus reactivation from latency.
Virus research 2008;132(1-2):257-62.
2008: Monika Barathova; Martina Takacova; T Holotnakova; A Gibadulinova; Anna Ohradanova; Miriam Zatovicova; A Hulikova; Juraj Kopacek; S Parkkila; Claudiu T Supuran; Silvia Pastorekova; Jaromir Pastorek
Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype.
British journal of cancer 2008;98(1):129-36.
2008: Silvia Pastorekova; Miriam Zatovicova; Jaromir Pastorek
Cancer-associated carbonic anhydrases and their inhibition.
Current pharmaceutical design 2008;14(7):685-98.
2008: Seppo Parkkila; Pei-Wen Pan; Aoife Ward; Adriana Gibadulinova; Ingrid Oveckova; Silvia Pastorekova; Jaromir Pastorek; Alejandra Rodriguez Martinez; Henrik O Helin; Jorma Isola
The calcium-binding protein S100P in normal and malignant human tissues.
BMC clinical pathology 2008;8():2.
2008: Sally Järvelä; Seppo Parkkila; Helena Bragge; Marketta Kähkönen; Anna-Kaisa Parkkila; Ylermi Soini; Silvia Pastorekova; Jaromir Pastorek; Hannu Haapasalo
Carbonic anhydrase IX in oligodendroglial brain tumors.
BMC cancer 2008;8():1.
2007: Martina Takacova; Monika Barathova; Alzbeta Hulikova; Anna Ohradanova; Juraj Kopacek; Seppo Parkkila; Jaromir Pastorek; Silvia Pastorekova; Miriam Zatovicova
Hypoxia-inducible expression of the mouse carbonic anhydrase IX demonstrated by new monoclonal antibodies.
International journal of oncology 2007;31(5):1103-10.
2007: Lubica Malekova; Jana Tomaskova; Marie Novakova; Peter Stefanik; Juraj Kopacek; Boris Lakatos; Silvia Pastorekova; Olga Krizanova; Albert Breier; Karol Ondrias
Inhibitory effect of DIDS, NPPB, and phloretin on intracellular chloride channels.
Pflügers Archiv : European journal of physiology 2007;455(2):349-57.
2007: Anna Ohradanova; Daniela Vullo; Juraj Kopacek; Claudia Temperini; Tatiana Betakova; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Reconstitution of carbonic anhydrase activity of the cell-surface-binding protein of vaccinia virus.
The Biochemical journal 2007;407(1):61-7.
2007: Anssi M Niemelä; Piritta Hynninen; Jukka-Pekka Mecklin; Teijo Kuopio; Antti Kokko; Lauri Aaltonen; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Torben F Orntoft; Mogens Kruhøffer; Hannu Haapasalo; Seppo Parkkila; Aarre Kivelä
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(9):1760-6.
2007: Angela van Baardwijk; Christophe Dooms; Robert J van Suylen; Erik Verbeken; Monique Hochstenbag; Cary Dehing-Oberije; Dennis Rupa; Silvia Pastorekova; Sigrid Stroobants; Udalrich Buell; Philippe Lambin; Johan Vansteenkiste; Dirk De Ruysscher
The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and GLUT-1 in non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990) 2007;43(9):1392-8.
2007: Sona Hudecova; Lucia Kubovcakova; Richard Kvetnansky; Juraj Kopacek; Silvia Pastorekova; Marie Novakova; V Knezl; Bohumila Tarabova; Lubica Lacinova; Z Sulova; Albert Breier; Dana Jurkovicova; Olga Krizanova
Modulation of expression of Na+/Ca2+ exchanger in heart of rat and mouse under stress.
Acta physiologica (Oxford, England) 2007;190(2):127-36.
2007: Dana Jurkovicova; Juraj Kopacek; Peter Stefanik; Lucia Kubovcakova; A Zahradnikova; A Zahradnikova; Silvia Pastorekova; Olga Krizanova
Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum.
Pflügers Archiv : European journal of physiology 2007;454(3):415-25.
2007: Riikka Riihonen; Claudiu T Supuran; Seppo Parkkila; Silvia Pastorekova; H Kalervo Väänänen; Tiina Laitala-Leinonen
Membrane-bound carbonic anhydrases in osteoclasts.
Bone 2007;40(4):1021-31.
2007: Alessio Innocenti; Daniela Vullo; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Isao Nishimori; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
Bioorganic & medicinal chemistry letters 2007;17(6):1532-7.
2007: L Hunakova; Juraj Bodo; Jana Chovancova; G Sulikova; Silvia Pastorekova; Jan Sedlak
Expression of new prognostic markers, peripheral-type benzodiazepine receptor and carbonic anhydrase IX, in human breast and ovarian carcinoma cell lines.
Neoplasma 2007;54(6):541-8.
2007: Silvia Pastorekova; Juraj Kopacek; Jaromir Pastorek
Carbonic anhydrase inhibitors and the management of cancer.
Current topics in medicinal chemistry 2007;7(9):865-78.
2006: Andrej Tillinger; Marie Novakova; M Pavlovicova; Lubica Lacinova; Miriam Zatovicova; Silvia Pastorekova; Olga Krizanova; Richard Kvetnansky
Modulation by 6-hydroxydopamine of expression of the phenylethanolamine N-methyltransferase (PNMT) gene in the rat heart during immobilization stress.
Stress (Amsterdam, Netherlands) 2006;9(4):207-13.
2006: Robert Ihnatko; Miroslav Kubes; Martina Takacova; Olga Sedlakova; Jan Sedlak; Jaromir Pastorek; Juraj Kopacek; Silvia Pastorekova
Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia.
International journal of oncology 2006;29(4):1025-33.
2006: Lisa Simi; Giulia Venturini; Francesca Malentacchi; Stefania Gelmini; Matteo Andreani; Alberto Janni; Silvia Pastorekova; Claudiu T Supuran; Mario Pazzagli; Claudio Orlando
Quantitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2006;52(1):59-66.
2006: Ann Driessen; Willy Landuyt; Silvia Pastorekova; Johnny Moons; Laurence Goethals; Karin Haustermans; Philippe Nafteux; Freddy Penninckx; Karel Geboes; Toni Lerut; Nadine Ectors
Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas.
Annals of surgery 2006;243(3):334-40.
2006: Peiwen Pan; Mari Leppilampi; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila
Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice.
The Journal of physiology 2006;571(Pt 2):319-27.
2006: Silvia Pastorekova; Seppo Parkkila; Jan Zavada
Tumor-associated carbonic anhydrases and their clinical significance.
Advances in clinical chemistry 2006;42():167-216.
2006: Heini Kallio; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Susanna Mannisto; Markku Heikinheimo; Seppo Parkkila
Expression of carbonic anhydrases IX and XII during mouse embryonic development.
BMC developmental biology 2006;6():22.
2005: Janka Sepelakova; Martina Takacova; Silvia Pastorekova; Juraj Kopacek
Involvement of upstream stimulatory factor in regulation of the mouse Prnd gene coding for Doppel protein.
Biochimica et biophysica acta 2005;1731(3):209-14.
2005: Miriam Zatovicova; O Sedlakova; E Svastova; Anna Ohradanova; Fedor Ciampor; J Arribas; Jaromir Pastorek; Silvia Pastorekova
Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17.
British journal of cancer 2005;93(11):1267-76.
2005: Magdalena Kowalewska; Jakub Radziszewski; Jadwiga Kulik; Monika Barathova; Anna Nasierowska-Guttmajer; Mariusz Bidziński; Jaromir Pastorek; Silvia Pastorekova; Janusz A Siedlecki
Detection of carbonic anhydrase 9-expressing tumor cells in the lymph nodes of vulvar carcinoma patients by RT-PCR.
International journal of cancer. Journal international du cancer 2005;116(6):957-62.
2005: Silvia Pastorekova; Daniela Vullo; Angela Casini; Andrea Scozzafava; Jaromir Pastorek; Isao Nishimori; Claudiu T Supuran
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2005;20(3):211-7.
2005: Juraj Kopacek; Monika Barathova; Franck Dequiedt; Janka Sepelakova; Richard Kettmann; Jaromir Pastorek; Silvia Pastorekova
MAPK pathway contributes to density- and hypoxia-induced expression of the tumor-associated carbonic anhydrase IX.
Biochimica et biophysica acta 2005;1729(1):41-9.
2005: Antti-J Kivela; Seppo Parkkila; Juha Saarnio; Tuomo J Karttunen; Jyrki Kivela; Anna-Kaisa Parkkila; Maria Bartosova; Vojtech Mucha; Michal Novak; Abdul Waheed; William S Sly; Hannu J Rajaniemi; Silvia Pastorekova; Jaromir Pastorek
Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.
World journal of gastroenterology : WJG 2005;11(17):2616-25.
2005: Jean-Yves Winum; Silvia Pastorekova; Lydia Jakubickova; Jean-Louis Montero; Andrea Scozzafava; Jaromir Pastorek; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Bioorganic & medicinal chemistry letters 2005;15(3):579-84.
2004: Piritta Hynninen; Jonna M Hämäläinen; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Eija Tomas; Pertti Kirkinen; Seppo Parkkila
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs.
Reproductive biology and endocrinology : RB&E 2004;2():73.
2004: Sergio Antonio Tripodi; Maria Teresa del Vecchio; Claudiu T Supuran; Andrea Scozzafava; M Gabriella Gabrielli; Silvia Pastorekova; Ranieri Rossie; Giuseppe Fasolis; Luca Puccetti
Redox state and carbonic anhydrase isozyme IX expression in human renal cell carcinoma: biochemical and morphological investigations.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):287-91.
2004: Silvia Pastorekova; Seppo Parkkila; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):199-229.
2004: Daniela Vullo; Andrea Scozzafava; Silvia Pastorekova; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.
Bioorganic & medicinal chemistry letters 2004;14(9):2351-6.
2004: Silvia Pastorekova; Angela Casini; Andrea Scozzafava; Daniela Vullo; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
Bioorganic & medicinal chemistry letters 2004;14(4):869-73.
2003: Daniela Vullo; Marco Franchi; Enzo Gallori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.
Journal of enzyme inhibition and medicinal chemistry 2003;18(5):403-6.
2003: Marco Franchi; Daniela Vullo; Enzo Gallori; Jaromir Pastorek; Antonella Russo; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides.
Journal of enzyme inhibition and medicinal chemistry 2003;18(4):333-8.
2003: Monica Ilies; Daniela Vullo; Jaromir Pastorek; Andrea Scozzafava; Marc A Ilies; Miron T Caproiu; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives.
Journal of medicinal chemistry 2003;46(11):2187-96.
2003: Daniela Vullo; Marco Franchi; Enzo Gallori; Jaromir Pastorek; Andrea Scozzafava; Silvia Pastorekova; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
Bioorganic & medicinal chemistry letters 2003;13(6):1005-9.
2001: Rene Opavsky; Peter Haviernik; Dana Jurkovicova; Matthew T Garin; Neal G Copeland; D J Gilbert; N A Jenkins; Juraj Bies; Susan H Garfield; Silvia Pastorekova; A Oue; Linda Wolff
Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.
The Journal of biological chemistry 2001;276(42):38795-807.
2001: A J Kivela; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; T S Parkkila; Hannu J Rajaniemi
Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors.
Digestive diseases and sciences 2001;46(10):2179-86.
2000: Seppo Parkkila; Hannu J Rajaniemi; Anna-Kaisa Parkkila; Jyrki Kivela; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; William S Sly
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2220-4.