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Ardem Patapoutian

Research Profile

Chemicals & Drugs

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Bertrand Coste; James Cox; Monica A Giovanni; Alexander Hoischen; Gunnar Houge; Matthew Lebo; Richard L Maas; Jayanti Mathur; Michael F Murray; Anthony Philippakis; Heidi Rehm; Gunnar Riemer; Unni Steen; Vidar Martin Steen; Nathan Stitziel; Shamil Sunyaev; Scott T Weiss; John N Wood; Michael Bandell; Ardem Patapoutian
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.
Bertrand Coste; Ardem Patapoutian
Neuroscience: Salty sensations.
Sung Eun Kim; Ardem Patapoutian; Jorg Grandl
Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations.

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All Publications

2013: Bertrand Coste; James Cox; Monica A Giovanni; Alexander Hoischen; Gunnar Houge; Matthew Lebo; Richard L Maas; Jayanti Mathur; Michael F Murray; Anthony Philippakis; Heidi Rehm; Gunnar Riemer; Unni Steen; Vidar Martin Steen; Nathan Stitziel; Shamil Sunyaev; Scott T Weiss; John N Wood; Michael Bandell; Ardem Patapoutian
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):4667-72.
2013: Bertrand Coste; Ardem Patapoutian
Neuroscience: Salty sensations.
Nature 2013;494(7435):44-5.
2013: Sung Eun Kim; Ardem Patapoutian; Jorg Grandl
Single Residues in the Outer Pore of TRPV1 and TRPV3 Have Temperature-Dependent Conformations.
PloS one 2013;8(3):e59593.
2012: Adrienne E Dubin; Jayanti Mathur; Matt J Petrus; Manuela Schmidt; Bailong Xiao; Bertrand Coste; Ardem Patapoutian
Inflammatory signals enhance piezo2-mediated mechanosensitive currents.
Cell reports 2012;2(3):511-7.
2012: Michael Bandell; Ardem Patapoutian
A hot new channel.
Nature neuroscience 2012;15(7):931-3.
2012: Bertrand Coste; Adrienne E Dubin; Jorg Grandl; Sung Eun Kim; Jayanti Mathur; Mauricio Montal; Jose S Santos; Manuela Schmidt; Kathryn S R Spencer; Ruhma Syeda; Bailong Xiao; Ardem Patapoutian
Piezo proteins are pore-forming subunits of mechanically activated channels.
Nature 2012;483(7388):176-81.
2012: Sung Eun Kim; Abhishek Chadha; Boaz Cook; Bertrand Coste; Ardem Patapoutian
The role of Drosophila Piezo in mechanical nociception.
Nature 2012;483(7388):209-12.
2011: Amanda L Blasius; José R Criado; Adrienne E Dubin; Cindy Ehlers; Kirk U Knowlton; Byung-Kwan Lim; Eva Marie Y Moresco; Anna Narezkina; Ardem Patapoutian; Matt J Petrus; Derek N Wills; Yu Xia; Bruce Beutler
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19413-8.
2011: Takashi Miyamoto; Ardem Patapoutian
Why does morphine make you itch?
Cell 2011;147(2):261-2.
2011: Bailong Xiao; Bertrand Coste; Jayanti Mathur; Ardem Patapoutian
Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression.
Nature chemical biology 2011;7(6):351-8.
2011: Bailong Xiao; Ardem Patapoutian
Scratching the surface: a role of pain-sensing TRPA1 in itch.
Nature neuroscience 2011;14(5):540-2.
2011: Takashi Miyamoto; Adrienne E Dubin; Matt J Petrus; Ardem Patapoutian
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin.
Nature communications 2011;2():369.
2010: Donato Del Camino; Sarah Murphy; Melissa Heiry; Lee B Barrett; Taryn J Earley; Colby A Cook; Matt J Petrus; Michael Zhao; Marc D'Amours; Nate Deering; Gary J Brenner; Michael Costigan; Neil J Hayward; Jayhong A Chong; Christopher M Fanger; Clifford J Woolf; Ardem Patapoutian; Magdalene M Moran
TRPA1 contributes to cold hypersensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(45):15165-74.
2010: Adrienne E Dubin; Ardem Patapoutian
Nociceptors: the sensors of the pain pathway.
The Journal of clinical investigation 2010;120(11):3760-72.
2010: Bertrand Coste; Jayanti Mathur; Manuela Schmidt; Taryn J Earley; Sanjeev Ranade; Matt J Petrus; Adrienne E Dubin; Ardem Patapoutian
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.
Science (New York, N.Y.) 2010;330(6000):55-60.
2010: Jörg Grandl; Sung Eun Kim; Valerie Uzzell; Badry Bursulaya; Matt J Petrus; Michael Bandell; Ardem Patapoutian
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.
Nature neuroscience 2010;13(6):708-14.
2010: Lindsey J Macpherson; Ardem Patapoutian
Channels: flies feel your pain.
Nature chemical biology 2010;6(4):252-3.
2009: Michael Bandell; Ardem Patapoutian
Itching for insight.
Cell 2009;139(7):1224-6.
2009: Manuela Schmidt; Adrienne E Dubin; Matt J Petrus; Taryn J Earley; Ardem Patapoutian
Nociceptive signals induce trafficking of TRPA1 to the plasma membrane.
Neuron 2009;64(4):498-509.
2009: Sravan Mandadi; Takaaki Sokabe; Koji Shibasaki; Kimiaki Katanosaka; Atsuko Mizuno; Aziz Moqrich; Ardem Patapoutian; Tomoko Fukumi-Tominaga; Kazue Mizumura; Makoto Tominaga
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP.
Pflügers Archiv : European journal of physiology 2009;458(6):1093-102.
2009: Hongzhen Hu; Michael Bandell; Matt J Petrus; Michael X Zhu; Ardem Patapoutian
Zinc activates damage-sensing TRPA1 ion channels.
Nature chemical biology 2009;5(3):183-90.
2009: Hongzhen Hu; Jorg Grandl; Michael Bandell; Matt J Petrus; Ardem Patapoutian
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1626-31.
2009: Ajay Dhaka; Valerie Uzzell; Adrienne E Dubin; Jayanti Mathur; Matt J Petrus; Michael Bandell; Ardem Patapoutian
TRPV1 is activated by both acidic and basic pH.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(1):153-8.
2009: Takashi Miyamoto; Adrienne E Dubin; Matt J Petrus; Ardem Patapoutian
TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice.
PloS one 2009;4(10):e7596.
2009: Ardem Patapoutian; Simon Tate; Clifford J Woolf
Transient receptor potential channels: targeting pain at the source.
Nature reviews. Drug discovery 2009;8(1):55-68.
2008: Bailong Xiao; Adrienne E Dubin; Badry Bursulaya; Veena Viswanath; Timothy J Jegla; Ardem Patapoutian
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(39):9640-51.
2008: Jorg Grandl; Hongzhen Hu; Michael Bandell; Badry Bursulaya; Manuela Schmidt; Matt J Petrus; Ardem Patapoutian
Pore region of TRPV3 ion channel is specifically required for heat activation.
Nature neuroscience 2008;11(9):1007-13.
2008: Ajay Dhaka; Taryn J Earley; James Watson; Ardem Patapoutian
Visualizing cold spots: TRPM8-expressing sensory neurons and their projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(3):566-75.
2007: Lindsey J Macpherson; Bailong Xiao; Kelvin Y Kwan; Matt J Petrus; Adrienne E Dubin; SunWook Hwang; Benjamin F Cravatt; David P Corey; Ardem Patapoutian
An ion channel essential for sensing chemical damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(42):11412-5.
2007: Michael Bandell; Lindsey J Macpherson; Ardem Patapoutian
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs.
Current opinion in neurobiology 2007;17(4):490-7.
2007: Ajay Dhaka; Amber N Murray; Jayanti Mathur; Taryn J Earley; Matt J Petrus; Ardem Patapoutian
TRPM8 is required for cold sensation in mice.
Neuron 2007;54(3):371-8.
2007: Katie S Kindt; Veena Viswanath; Lindsey J Macpherson; Kathleen Quast; Hongzhen Hu; Ardem Patapoutian; William R Schafer
Caenorhabditis elegans TRPA-1 functions in mechanosensation.
Nature neuroscience 2007;10(5):568-77.
2007: Lindsey J Macpherson; Adrienne E Dubin; Michael J Evans; Felix Marr; Peter G Schultz; Benjamin F Cravatt; Ardem Patapoutian
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
Nature 2007;445(7127):541-5.
2007: Matt J Petrus; Andrea M Peier; Michael Bandell; Sun Wook Hwang; Truc Huynh; Nicholas Olney; Tim Jegla; Ardem Patapoutian
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.
Molecular pain 2007;3():40.
2006: Clare J McCleverty; Eric Koesema; Ardem Patapoutian; Scott A Lesley; Andreas Kreusch
Crystal structure of the human TRPV2 channel ankyrin repeat domain.
Protein science : a publication of the Protein Society 2006;15(9):2201-6.
2006: Alan Saghatelian; Michele K McKinney; Michael Bandell; Ardem Patapoutian; Benjamin F Cravatt
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels.
Biochemistry 2006;45(30):9007-15.
2006: Lindsey J Macpherson; Sun Wook Hwang; Takashi Miyamoto; Adrienne E Dubin; Ardem Patapoutian; Gina M Story
More than cool: promiscuous relationships of menthol and other sensory compounds.
Molecular and cellular neurosciences 2006;32(4):335-43.
2006: Ardem Patapoutian; Lindsey J Macpherson
Channeling pain.
Nature medicine 2006;12(5):506-7.
2006: Michael Bandell; Adrienne E Dubin; Matt J Petrus; Anthony P Orth; Jayanti Mathur; Sun Wook Hwang; Ardem Patapoutian
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol.
Nature neuroscience 2006;9(4):493-500.
2006: Ajay Dhaka; Veena Viswanath; Ardem Patapoutian
Trp ion channels and temperature sensation.
Annual review of neuroscience 2006;29():135-61.
2005: Lindsey J Macpherson; Bernhard H Geierstanger; Veena Viswanath; Michael Bandell; Samer R Eid; SunWook Hwang; Ardem Patapoutian
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.
Current biology : CB 2005;15(10):929-34.
2005: Aziz Moqrich; Sun Wook Hwang; Taryn J Earley; Matt J Petrus; Amber N Murray; Kathryn S R Spencer; Mary Andahazy; Gina M Story; Ardem Patapoutian
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.
Science (New York, N.Y.) 2005;307(5714):1468-72.
2005: Mark Rosenzweig; Karen M Brennan; Timothy D Tayler; Paul O Phelps; Ardem Patapoutian; Paul A Garrity
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis.
Genes & development 2005;19(4):419-24.
2005: Ardem Patapoutian
TRP channels and thermosensation.
Chemical senses 2005;30 Suppl 1():i193-4.
2004: Aziz Moqrich; Taryn J Earley; James Watson; Mary Andahazy; Carey Backus; Dionisio Martin-Zanca; Douglas E Wright; Louis F Reichardt; Ardem Patapoutian
Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.
Nature neuroscience 2004;7(8):812-8.
2004: Michael Bandell; Gina M Story; Sun Wook Hwang; Veena Viswanath; Samer R Eid; Matt J Petrus; Taryn J Earley; Ardem Patapoutian
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
Neuron 2004;41(6):849-57.
2003: Ardem Patapoutian; Andrea M Peier; Gina M Story; Veena Viswanath
ThermoTRP channels and beyond: mechanisms of temperature sensation.
Nature reviews. Neuroscience 2003;4(7):529-39.
2003: Veena Viswanath; Gina M Story; Andrea M Peier; Matt J Petrus; Van M Lee; Sun Wook Hwang; Ardem Patapoutian; Tim Jegla
Opposite thermosensor in fruitfly and mouse.
Nature 2003;423(6942):822-3.
2003: Gina M Story; Andrea M Peier; Alison J Reeve; Samer R Eid; Johannes Mosbacher; Todd R Hricik; Taryn J Earley; Anne C Hergarden; David A Andersson; Sun Wook Hwang; Peter McIntyre; Tim Jegla; Stuart Bevan; Ardem Patapoutian
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Cell 2003;112(6):819-29.
2002: Andrea M Peier; Alison J Reeve; David A Andersson; Aziz Moqrich; Taryn J Earley; Anne C Hergarden; Gina M Story; Sian Colley; John B Hogenesch; Peter McIntyre; Stuart Bevan; Ardem Patapoutian
A heat-sensitive TRP channel expressed in keratinocytes.
Science (New York, N.Y.) 2002;296(5575):2046-9.
2002: Andrew Su; Michael P Cooke; Keith A Ching; Yaron Hakak; John R Walker; Timothy Wiltshire; Anthony P Orth; Raquel G Vega; Lisa M Sapinoso; Aziz Moqrich; Ardem Patapoutian; Garret M Hampton; Peter G Schultz; John B Hogenesch
Large-scale analysis of the human and mouse transcriptomes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4465-70.
2002: Andrea M Peier; Aziz Moqrich; Anne C Hergarden; Alison J Reeve; David A Andersson; Gina M Story; Taryn J Earley; Ilaria Dragoni; Peter McIntyre; Stuart Bevan; Ardem Patapoutian
A TRP channel that senses cold stimuli and menthol.
Cell 2002;108(5):705-15.
2001: Ardem Patapoutian
Making the pain connection.
Neuron 2001;31(1):4-6.
2001: Ardem Patapoutian; Louis F Reichardt
Trk receptors: mediators of neurotrophin action.
Current opinion in neurobiology 2001;11(3):272-80.
2000: Ardem Patapoutian; Louis F Reichardt
Roles of Wnt proteins in neural development and maintenance.
Current opinion in neurobiology 2000;10(3):392-9.
1999: Ardem Patapoutian; Carey Backus; A Kispert; Louis F Reichardt
Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors.
Science (New York, N.Y.) 1999;283(5405):1180-3.
1998: Isabel Fariñas; George A Wilkinson; Carey Backus; Louis F Reichardt; Ardem Patapoutian
Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo.
Neuron 1998;21(2):325-34.