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Mulchand Patel

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Ewa K Stachowiak; Michal Stachowiak; Vihas T Vasu; Kishorchandra Gohil; Saji Oommen; Malathi Srinivasan; Mulchand S Patel
Maternal obesity affects gene expression and cellular development in fetal brains.
Malathi Srinivasan; Saleh Mahmood; Mulchand S Patel
Metabolic programming effects initiated in the suckling period predisposing for adult-onset obesity cannot be reversed by calorie restriction.
Isaac Marin-Valencia; Levi B Good; Qian Ma; Craig R Malloy; Mulchand S Patel; Juan M Pascual
Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain.

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2013: Ewa K Stachowiak; Michal Stachowiak; Vihas T Vasu; Kishorchandra Gohil; Saji Oommen; Malathi Srinivasan; Mulchand S Patel
Maternal obesity affects gene expression and cellular development in fetal brains.
Nutritional neuroscience 2013;16(3):96-103.
2013: Malathi Srinivasan; Saleh Mahmood; Mulchand S Patel
Metabolic programming effects initiated in the suckling period predisposing for adult-onset obesity cannot be reversed by calorie restriction.
American journal of physiology. Endocrinology and metabolism 2013;304(5):E486-94.
2012: Isaac Marin-Valencia; Levi B Good; Qian Ma; Craig R Malloy; Mulchand S Patel; Juan M Pascual
Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain.
Neurochemistry international 2012;61(7):1036-43.
2012: Raza Patel; Adil Sarfraz; Helen Vlassara; Razan Alkhouri; Robert D Baker; Susan S Baker; Weijing Cai; Sonal Desai; Rafal Kozielski; Wensheng Liu; Lucy Mastrandrea; Mulchand S Patel; Lixin Zhu
Effect of dietary advanced glycation end products on mouse liver.
PloS one 2012;7(4):e35143.
2011: Matan Rapoport; Lina Salman; Ofra Sabag; Mulchand S Patel; Haya Lorberboum-Galski
Successful TAT-mediated enzyme replacement therapy in a mouse model of mitochondrial E3 deficiency.
Journal of molecular medicine (Berlin, Germany) 2011;89(2):161-70.
2011: Mulchand S Patel; Malathi Srinivasan
Metabolic programming in the immediate postnatal life.
Annals of nutrition & metabolism 2011;58 Suppl 2():18-28.
2010: Malathi Srinivasan; Cheol S Choi; Pushpankur Ghoshal; Lioudmila Pliss; Jignesh D Pandya; David Hill; Gary Cline; Mulchand S Patel
ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.
American journal of physiology. Endocrinology and metabolism 2010;299(6):E910-7.
2010: Cheol Soo Choi; Pushpankur Ghoshal; Malathi Srinivasan; Sheene Kim; Gary Cline; Mulchand S Patel
Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity.
Lipids 2010;45(11):987-95.
2010: Nader D Halim; Thomas McFate; Ahmed Mohyeldin; Peter Okagaki; Lioubov G Korotchkina; Mulchand S Patel; Nam Ho Jeoung; Robert A Harris; Michael J Schell; Ajay Verma
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.
Glia 2010;58(10):1168-76.
2010: Yun-Hee Park; Mulchand S Patel
Characterization of interactions of dihydrolipoamide dehydrogenase with its binding protein in the human pyruvate dehydrogenase complex.
Biochemical and biophysical research communications 2010;395(3):416-9.
2010: Ruslana Bryk; Nancy Arango; Aditya Venugopal; J David Warren; Yun-Hee Park; Mulchand S Patel; Christopher D Lima; Carl Nathan
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Biochemistry 2010;49(8):1616-27.
2010: Mulchand S Patel; Malathi Srinivasan
Metabolic programming due to alterations in nutrition in the immediate postnatal period.
The Journal of nutrition 2010;140(3):658-61.
2009: Mulchand S Patel; Malathi Srinivasan; Suzanne G Laychock
Metabolic programming: Role of nutrition in the immediate postnatal life.
Journal of inherited metabolic disease 2009;32(2):218-28.
2009: Anshu Gupta; Malathi Srinivasan; Supaporn Thamadilok; Mulchand S Patel
Hypothalamic alterations in fetuses of high fat diet-fed obese female rats.
The Journal of endocrinology 2009;200(3):293-300.
2008: Malathi Srinivasan; Catherine Dodds; Husam Ghanim; Tao Gao; Peter J Ross; Richard W Browne; Paresh Dandona; Mulchand S Patel
Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats.
American journal of physiology. Endocrinology and metabolism 2008;295(4):E895-903.
2008: Sukhdeep Sidhu; Ashish Gangasani; Lioubov G Korotchkina; Gen Suzuki; James A Fallavollita; John M Canty; Mulchand S Patel
Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice.
American journal of physiology. Heart and circulatory physiology 2008;295(3):H946-H952.
2008: Malathi Srinivasan; Paul Mitrani; Gigani Sadhanandan; Catherine Dodds; Suhad Shbeir-ElDika; Shanthie Thamotharan; Hussam Ghanim; Paresh Dandona; Sherin U Devaskar; Mulchand S Patel
A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity.
The Journal of endocrinology 2008;197(3):565-74.
2008: Malathi Srinivasan; Mulchand S Patel
Metabolic programming in the immediate postnatal period.
Trends in endocrinology and metabolism: TEM 2008;19(4):146-52.
2008: K Okajima; L G Korotchkina; C Prasad; T Rupar; J A Phillips; C Ficicioglu; J Hertecant; Mulchand S Patel; Douglas S Kerr
Mutations of the E1beta subunit gene (PDHB) in four families with pyruvate dehydrogenase deficiency.
Molecular genetics and metabolism 2008;93(4):371-80.
2008: Lioubov G Korotchkina; Mulchand S Patel
Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex.
FEBS letters 2008;582(3):468-72.
2008: Brian Page; Rebeccah Young; Vijay Iyer; Gen Suzuki; Maciej Lis; Lioubov G Korotchkina; Mulchand S Patel; Kenneth M Blumenthal; James A Fallavollita; John M Canty
Persistent regional downregulation in mitochondrial enzymes and upregulation of stress proteins in swine with chronic hibernating myocardium.
Circulation research 2008;102(1):103-12.
2008: Christoph M Schummer; Ulrich Werner; Norbert Tennagels; Dieter Schmoll; Guido Haschke; Hans-Paul Juretschke; Mulchand S Patel; Martin Gerl; Werner Kramer; Andreas W Herling
Dysregulated pyruvate dehydrogenase complex in Zucker diabetic fatty rats.
American journal of physiology. Endocrinology and metabolism 2008;294(1):E88-96.
2007: Natalia Nemeria; Lioubov G Korotchkina; Michael McLeish; George L Kenyon; Mulchand S Patel; Frank Jordan
Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states.
Biochemistry 2007;46(37):10739-44.
2007: Franziska Seifert; Ewa M Ciszak; Lioubov G Korotchkina; Ralph Golbik; Michael Spinka; Paulina Dominiak; Sukhdeep Sidhu; Johanna Brauer; Mulchand S Patel; Kai Tittmann
Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex.
Biochemistry 2007;46(21):6277-87.
2007: Paul Mitrani; Malathi Srinivasan; Catherine Dodds; Mulchand S Patel
Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.
American journal of physiology. Endocrinology and metabolism 2007;292(5):E1364-77.
2007: Lioudmila Pliss; richard mazurchuk; Joseph Spernyak; Mulchand S Patel
Brain MR imaging and proton MR spectroscopy in female mice with pyruvate dehydrogenase complex deficiency.
Neurochemical research 2007;32(4-5):645-54.
2007: Paul Mitrani; Malathi Srinivasan; Catherine Dodds; Mulchand S Patel
Role of the autonomic nervous system in the development of hyperinsulinemia by high-carbohydrate formula feeding to neonatal rats.
American journal of physiology. Endocrinology and metabolism 2007;292(4):E1069-78.
2007: Jason Jell; Salim Merali; Mary L Hensen; richard mazurchuk; Joseph Spernyak; Paula Diegelman; Nicholas Kisiel; Carlos Barrero; Kristin K Deeb; Leena Alhonen; Mulchand S Patel; Carl W Porter
Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.
The Journal of biological chemistry 2007;282(11):8404-13.
2007: Natalia Nemeria; Sumit Chakraborty; Ahmet Baykal; Lioubov G Korotchkina; Mulchand S Patel; Frank Jordan
The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):78-82.
2006: Natalia Nemeria; Lioubov G Korotchkina; Sumit Chakraborty; Mulchand S Patel; Frank Jordan
Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex.
Bioorganic chemistry 2006;34(6):362-79.
2006: Franziska Seifert; Ralph Golbik; Johanna Brauer; Hauke Lilie; Kathrin Schröder-Tittmann; Erik Hinze; Lioubov G Korotchkina; Mulchand S Patel; Kai Tittmann
Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation.
Biochemistry 2006;45(42):12775-85.
2006: Malathi Srinivasan; Subhash D Katewa; Arivazhagan Palaniyappan; Jignesh D Pandya; Mulchand S Patel
Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood.
American journal of physiology. Endocrinology and metabolism 2006;291(4):E792-9.
2006: Lioubov G Korotchkina; Sukhdeep Sidhu; Mulchand S Patel
Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase.
The Journal of biological chemistry 2006;281(14):9688-96.
2006: Mulchand S Patel; Lioubov G Korotchkina
Regulation of the pyruvate dehydrogenase complex.
Biochemical Society transactions 2006;34(Pt 2):217-22.
2006: Ewa M Ciszak; Anna Makal; Young S Hong; Ananthalakshmy K Vettaikkorumakankauv; Lioubov G Korotchkina; Mulchand S Patel
How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.
The Journal of biological chemistry 2006;281(1):648-55.
2006: Malathi Srinivasan; Ravikumar Aalinkeel; Fei Song; Paul Mitrani; Jignesh D Pandya; Brenda Strutt; David J Hill; Mulchand S Patel
Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype.
American journal of physiology. Endocrinology and metabolism 2006;290(1):E129-E134.
2005: Mulchand S Patel; Malathi Srinivasan; Suzanne G Laychock
Nutrient-induced maternal hyperinsulinemia and metabolic programming in the progeny.
Nestlé Nutrition workshop series. Paediatric programme 2005;55():137-47; discussion 147-51.
2004: Lioudmila Pliss; Roberta J Pentney; Mark T Johnson; Mulchand S Patel
Biochemical and structural brain alterations in female mice with cerebral pyruvate dehydrogenase deficiency.
Journal of neurochemistry 2004;91(5):1082-91.
2004: Lioubov G Korotchkina; Sukhdeep Sidhu; Mulchand S Patel
R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.
Free radical research 2004;38(10):1083-92.
2004: Lioubov G Korotchkina; Ewa M Ciszak; Mulchand S Patel
Function of several critical amino acids in human pyruvate dehydrogenase revealed by its structure.
Archives of biochemistry and biophysics 2004;429(2):171-9.
2004: anatoly starkov; Gary Fiskum; Chinopoulos Christos; Beverly J Lorenzo; Susan E Browne; Mulchand S Patel; M Flint Beal
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(36):7779-88.
2004: Peter Klivenyi; anatoly starkov; Noel Y Calingasan; Gabrielle Gardian; Susan E Browne; Lichuan Yang; Parvesh Bubber; Gary Gibson; Mulchand S Patel; M Flint Beal
Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.
Journal of neurochemistry 2004;88(6):1352-60.
2003: Mark T Johnson; Saleh Mahmood; Mulchand S Patel
Intermediary metabolism and energetics during murine early embryogenesis.
The Journal of biological chemistry 2003;278(34):31457-60.
2003: Ewa M Ciszak; Lioubov G Korotchkina; Paulina Dominiak; Sukhdeep Sidhu; Mulchand S Patel
Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase.
The Journal of biological chemistry 2003;278(23):21240-6.
2003: Malathi Srinivasan; Ravikumar Aalinkeel; Fei Song; Mulchand S Patel
Programming of islet functions in the progeny of hyperinsulinemic/obese rats.
Diabetes 2003;52(4):984-90.
2003: Young S Hong; Stanley H Korman; J Lee; P Ghoshal; Q Wu; Varda Barash; S Kang; S Oh; M Kwon; Alisa Gutman; A Rachmel; Mulchand S Patel
Identification of a common mutation (Gly194Cys) in both Arab Moslem and Ashkenazi Jewish patients with dihydrolipoamide dehydrogenase (E3) deficiency: possible beneficial effect of vitamin therapy.
Journal of inherited metabolic disease 2003;26(8):816-8.
2003: Malathi Srinivasan; Suzanne G Laychock; David J Hill; Mulchand S Patel
Neonatal nutrition: metabolic programming of pancreatic islets and obesity.
Experimental biology and medicine (Maywood, N.J.) 2003;228(1):15-23.
2002: Mulchand S Patel; Malathi Srinivasan
Metabolic programming: causes and consequences.
The Journal of biological chemistry 2002;277(3):1629-32.
2002: Scott J Jacobia; Lioubov G Korotchkina; Mulchand S Patel
Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient.
Biochimica et biophysica acta 2002;1586(1):32-42.
2002: Mulchand S Patel; Lioubov G Korotchkina
Pyruvate dehydrogenase complex as a marker of mitochondrial metabolism. Inhibition by 4-hydroxy-2-nonenal.
Methods in molecular biology (Clifton, N.J.) 2002;186():255-63.
2001: Mulchand S Patel; Lioubov G Korotchkina
Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases.
Experimental & molecular medicine 2001;33(4):191-7.
2001: Mark T Johnson; S Mahmood; Susannah L Hyatt; H S Yang; P D Soloway; Richard W Hanson; Mulchand S Patel
Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development.
Molecular genetics and metabolism 2001;74(3):293-302.
2001: Scott J Jacobia; Lioubov G Korotchkina; Mulchand S Patel
Differential effects of two mutations at arginine-234 in the alpha subunit of human pyruvate dehydrogenase.
Archives of biochemistry and biophysics 2001;395(1):121-8.
2001: Lioubov G Korotchkina; Mulchand S Patel
Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.
The Journal of biological chemistry 2001;276(40):37223-9.
2001: Fei Song; Malathi Srinivasan; Ravikumar Aalinkeel; Mulchand S Patel
Use of a cDNA array for the identification of genes induced in islets of suckling rats by a high-carbohydrate nutritional intervention.
Diabetes 2001;50(9):2053-60.
2001: Ravikumar Aalinkeel; Malathi Srinivasan; Fei Song; Mulchand S Patel
Programming into adulthood of islet adaptations induced by early nutritional intervention in the rat.
American journal of physiology. Endocrinology and metabolism 2001;281(3):E640-8.
2001: HS Yang; J I Morris; Q Wang; Lioubov G Korotchkina; M Kwon; Mulchand S Patel
Human dihydrolipoamide dehydrogenase gene transcription is mediated by cAMP-response element-like site and TACGAC direct repeat.
The international journal of biochemistry & cell biology 2001;33(9):902-13.
2001: Lioubov G Korotchkina; H Yang; O Tirosh; L Packer; Mulchand S Patel
Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal.
Free radical biology & medicine 2001;30(9):992-9.
2001: Ewa M Ciszak; Lioubov G Korotchkina; Young S Hong; A Joachimiak ; Mulchand S Patel
Crystallization and initial X-ray diffraction analysis of human pyruvate dehydrogenase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 3):465-8.
2001: Lioubov G Korotchkina; Mulchand S Patel
Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites.
The Journal of biological chemistry 2001;276(8):5731-8.
2001: B Lee; Malathi Srinivasan; Ravikumar Aalinkeel; Mulchand S Patel; Suzanne G Laychock
Mitochondrial-encoded gene regulation in rat pancreatic islets.
Metabolism: clinical and experimental 2001;50(2):200-6.
2000: Malathi Srinivasan; Ravikumar Aalinkeel; Fei Song; B Lee; Suzanne G Laychock; Mulchand S Patel
Adaptive changes in insulin secretion by islets from neonatal rats raised on a high-carbohydrate formula.
American journal of physiology. Endocrinology and metabolism 2000;279(6):E1347-57.
2000: Mulchand S Patel; Malathi Srinivasan; Ravikumar Aalinkeel
Metabolic programming by nutrition during early development.
Indian journal of experimental biology 2000;38(9):849-55.
2000: Mark T Johnson; HS Yang; Mulchand S Patel
Targeting E3 component of alpha-keto acid dehydrogenase complexes.
Methods in enzymology 2000;324():465-76.
2000: Mulchand S Patel; Young S Hong; Douglas S Kerr
Genetic defects in E3 component of alpha-keto acid dehydrogenase complexes.
Methods in enzymology 2000;324():453-64.
2000: Willy Lissens; Linda De Meirleir; Sara Seneca; Inge Liebaers; G K Brown; R M Brown; M Ito; E Naito; Y Kuroda; Douglas S Kerr; ID Wexler; Mulchand S Patel; B H Robinson; A Seyda
Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency.
Human mutation 2000;15(3):209-19.
1999: Ravikumar Aalinkeel; Malathi Srinivasan; Satish Kalhan; Suzanne G Laychock; Mulchand S Patel
A dietary intervention (high carbohydrate) during the neonatal period causes islet dysfunction in rats.
The American journal of physiology 1999;277(6 Pt 1):E1061-9.
1999: U Datta; ID Wexler; Douglas S Kerr; I Raz; Mulchand S Patel
Characterization of the regulatory region of the human testis-specific form of the pyruvate dehydrogenase alpha-subunit (PDHA-2) gene.
Biochimica et biophysica acta 1999;1447(2-3):236-43.
1999: Lioubov G Korotchkina; M Showkat Ali; Mulchand S Patel
Involvement of alpha-cysteine-62 and beta-tryptophan-135 in human pyruvate dehydrogenase catalysis.
Archives of biochemistry and biophysics 1999;369(2):277-87.
1999: A Tripatara; Lioubov G Korotchkina; Mulchand S Patel
Characterization of point mutations in patients with pyruvate dehydrogenase deficiency: role of methionine-181, proline-188, and arginine-349 in the alpha subunit.
Archives of biochemistry and biophysics 1999;367(1):39-50.
1999: T C Liu; Young S Hong; Lioubov G Korotchkina; N N Vettakkorumakankav; Mulchand S Patel
Site-directed mutagenesis of human dihydrolipoamide dehydrogenase: role of lysine-54 and glutamate-192 in stabilizing the thiolate-FAD intermediate.
Protein expression and purification 1999;16(1):27-39.
1999: J Tan; Mulchand S Patel
Cloning and characterization of a 5.9 kb promoter region of the human pyruvate dehydrogenase alpha subunit gene.
Biochimica et biophysica acta 1999;1431(2):531-7.
1999: HS Yang; Mark T Johnson; Mulchand S Patel
Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide dehydrogenase (Dld) gene.
The Biochemical journal 1999;338 ( Pt 3)():667-75.
1999: Young S Hong; Scott J Jacobia; L Packer; Mulchand S Patel
The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components.
Free radical biology & medicine 1999;26(5-6):685-94.
1998: J Tan; HS Yang; Mulchand S Patel
Regulation of mammalian pyruvate dehydrogenase alpha subunit gene expression by glucose in HepG2 cells.
The Biochemical journal 1998;336 ( Pt 1)():49-56.
1998: Mulchand S Patel; Young S Hong
Lipoic acid as an antioxidant. The role of dihydrolipoamide dehydrogenase.
Methods in molecular biology (Clifton, N.J.) 1998;108():337-46.
1997: Young S Hong; Douglas S Kerr; T C Liu; M Lusk; B R Powell; Mulchand S Patel
Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101del). Analysis of a family and prenatal testing.
Biochimica et biophysica acta 1997;1362(2-3):160-8.
1997: Mark T Johnson; HS Yang; Terry Magnuson; Mulchand S Patel
Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14512-7.
1997: ID Wexler; S G Hemalatha; J McConnell; N R Buist; H H Dahl; SA Berry; Stephen D Cederbaum; Mulchand S Patel; Douglas S Kerr
Outcome of pyruvate dehydrogenase deficiency treated with ketogenic diets. Studies in patients with identical mutations.
Neurology 1997;49(6):1655-61.
1997: M Johnson; HS Yang; G L Johanning; Mulchand S Patel
Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene: genomic structure, promoter sequence, and chromosomal localization.
Genomics 1997;41(3):320-6.
1996: Young S Hong; Douglas S Kerr; W J Craigen; J Tan; Y Pan; M Lusk; Mulchand S Patel
Identification of two mutations in a compound heterozygous child with dihydrolipoamide dehydrogenase deficiency.
Human molecular genetics 1996;5(12):1925-30.
1996: M Srinivasan; Satyaprasad Vadlamudi; Mulchand S Patel
Glycogen synthase regulation in hyperinsulinemic/obese progeny of rats fed a high carbohydrate formula in their infancy.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(11):981-9.
1996: R Dey; S Naik; Mulchand S Patel
Tissue-specific expression of the human pyruvate dehydrogenase alpha (Pdha-1)/chloramphenicol acetyltransferase fusion gene in transgenic mice.
Biochimica et biophysica acta 1996;1305(3):189-95.
1996: A Tripatara; Douglas S Kerr; M M Lusk; M Kolli; J Tan; Mulchand S Patel
Three new mutations of the pyruvate dehydrogenase alpha subunit: a point mutation (M181V), 3 bp deletion (-R282), and 16 bp insertion/frameshift (K358SVS-->TVDQS).
Human mutation 1996;8(2):180-2.
1995: D Eswaran; M S Ali; BC Shenoy; L G Korotchkina; T E Roche; Mulchand S Patel
Arginine-239 in the beta subunit is at or near the active site of bovine pyruvate dehydrogenase.
Biochimica et biophysica acta 1995;1252(2):203-8.
1995: Satyaprasad Vadlamudi; Satish C Kalhan; Mulchand S Patel
Persistence of metabolic consequences in the progeny of rats fed a HC formula in their early postnatal life.
The American journal of physiology 1995;269(4 Pt 1):E731-8.
1995: Mulchand S Patel; R A Harris
Mammalian alpha-keto acid dehydrogenase complexes: gene regulation and genetic defects.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(12):1164-72.
1995: T C Liu; L G Korotchkina; Susannah L Hyatt; N N Vettakkorumakankav; Mulchand S Patel
Spectroscopic studies of the characterization of recombinant human dihydrolipoamide dehydrogenase and its site-directed mutants.
The Journal of biological chemistry 1995;270(26):15545-50.
1995: L G Korotchkina; Mulchand S Patel
Mutagenesis studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation.
The Journal of biological chemistry 1995;270(24):14297-304.
1995: Mulchand S Patel; S Naik; ID Wexler; Douglas S Kerr
Gene regulation and genetic defects in the pyruvate dehydrogenase complex.
The Journal of nutrition 1995;125(6 Suppl):1753S-1757S.
1995: Mulchand S Patel; R A Harris
Alpha-keto acid dehydrogenase complexes: nutrient control, gene regulation and genetic defects. Overview.
The Journal of nutrition 1995;125(6 Suppl):1744S-1745S.
1995: M S Ali; BC Shenoy; D Eswaran; L A Andersson; T E Roche; Mulchand S Patel
Identification of the tryptophan residue in the thiamin pyrophosphate binding site of mammalian pyruvate dehydrogenase.
The Journal of biological chemistry 1995;270(9):4570-4.
1995: S G Hemalatha; Douglas S Kerr; ID Wexler; M M Lusk; M Kaung; Y Du; M Kolli; R L Schelper; Mulchand S Patel
Pyruvate dehydrogenase complex deficiency due to a point mutation (P188L) within the thiamine pyrophosphate binding loop of the E1 alpha subunit.
Human molecular genetics 1995;4(2):315-8.
1995: L G Korotchkina; M M Tucker; T J Thekkumkara; K T Madhusudhan; G Pons; H Kim; Mulchand S Patel
Overexpression and characterization of human tetrameric pyruvate dehydrogenase and its individual subunits.
Protein expression and purification 1995;6(1):79-90.
1995: K T Madhusudhan; S S Naik; Mulchand S Patel
Characterization of the promoter regulatory region of the human pyruvate dehydrogenase beta gene.
Biochemistry 1995;34(4):1288-94.
1994: ID Wexler; Y Du; M V Lisgaris; S K Mandal; Svend O Freytag; B S Yang; T C Liu; M Kwon; Mulchand S Patel; Douglas S Kerr
Primary amino acid sequence and structure of human pyruvate carboxylase.
Biochimica et biophysica acta 1994;1227(1-2):46-52.
1994: Mulchand S Patel; Satyaprasad Vadlamudi; G L Johanning
Artificial rearing of rat pups: implications for nutrition research.
Annual review of nutrition 1994;14():21-40.
1993: M S Ali; T E Roche; Mulchand S Patel
Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase.
The Journal of biological chemistry 1993;268(30):22353-6.
1993: Satyaprasad Vadlamudi; B K Hiremagalur; L Tao; Satish C Kalhan; Rajesh N. Kalaria; Hue-Lee C Kaung; Mulchand S Patel
Long-term effects on pancreatic function of feeding a HC formula to rats during the preweaning period.
The American journal of physiology 1993;265(4 Pt 1):E565-71.
1993: B K Hiremagalur; Satyaprasad Vadlamudi; G L Johanning; Mulchand S Patel
Long-term effects of feeding high carbohydrate diet in pre-weaning period by gastrostomy: a new rat model for obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1993;17(9):495-502.
1993: T C Liu; H Kim; C Arizmendi; A Kitano; Mulchand S Patel
Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5186-90.
1993: M Chang; S Naik; G L Johanning; L Ho; Mulchand S Patel
Multiple protein-binding domains and functional cis-elements in the 5'-flanking region of the human pyruvate dehydrogenase alpha-subunit gene.
Biochemistry 1993;32(16):4263-9.
1993: Mulchand S Patel; Satyaprasad Vadlamudi; G L Johanning
Overview of pup in a cup model: hepatic lipogenesis in rats artificially reared on a high-carbohydrate formula.
The Journal of nutrition 1993;123(2 Suppl):373-7.
1992: G L Johanning; J I Morris; K T Madhusudhan; D Samols; Mulchand S Patel
Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10964-8.
1992: J E Jentoft; Menachem Shoham; D Hurst; Mulchand S Patel
A structural model for human dihydrolipoamide dehydrogenase.
Proteins 1992;14(1):88-101.
1992: ID Wexler; S G Hemalatha; T C Liu; S A Berry; Douglas S Kerr; Mulchand S Patel
A mutation in the E1 alpha subunit of pyruvate dehydrogenase associated with variable expression of pyruvate dehydrogenase complex deficiency.
Pediatric research 1992;32(2):169-74.
1992: H Kim; Mulchand S Patel
Characterization of two site-specifically mutated human dihydrolipoamide dehydrogenases (His-452----Gln and Glu-457----Gln).
The Journal of biological chemistry 1992;267(8):5128-32.
1992: Mulchand S Patel; B K Hiremagalur
Artificial-rearing technique: its usefulness in nutrition research.
The Journal of nutrition 1992;122(3):412-9.
1992: Hans-Henrik M Dahl; G K Brown; R M Brown; L L Hansen; Douglas S Kerr; ID Wexler; Mulchand S Patel; L De Meirleir; W Lissens; K Chun
Mutations and polymorphisms in the pyruvate dehydrogenase E1 alpha gene.
Human mutation 1992;1(2):97-102.
1991: H Kim; T C Liu; Mulchand S Patel
Expression of cDNA sequences encoding mature and precursor forms of human dihydrolipoamide dehydrogenase in Escherichia coli. Differences in kinetic mechanisms.
The Journal of biological chemistry 1991;266(15):9367-73.
1991: ID Wexler; S G Hemalatha; Mulchand S Patel
Sequence conservation in the alpha and beta subunits of pyruvate dehydrogenase and its similarity to branched-chain alpha-keto acid dehydrogenase.
FEBS letters 1991;282(1):209-13.
1990: Mulchand S Patel; T E Roche
Molecular biology and biochemistry of pyruvate dehydrogenase complexes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(14):3224-33.
1990: L Ho; Mulchand S Patel
Cloning and cDNA sequence of the beta-subunit component of human pyruvate dehydrogenase complex.
Gene 1990;86(2):297-302.
1989: T J Thekkumkara; Mulchand S Patel
Ochratoxin A decreases the activity of phosphoenolpyruvate carboxykinase and its mRNA content in primary cultures of rat kidney proximal convoluted tubule cells.
Biochemical and biophysical research communications 1989;162(3):916-20.
1989: L Ho; ID Wexler; T C Liu; T J Thekkumkara; Mulchand S Patel
Characterization of cDNAs encoding human pyruvate dehydrogenase alpha subunit.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5330-4.
1989: D J Carothers; G Pons; Mulchand S Patel
Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases.
Archives of biochemistry and biophysics 1989;268(2):409-25.
1989: L Ho; ID Wexler; Douglas S Kerr; Mulchand S Patel
Genetic defects in human pyruvate dehydrogenase.
Annals of the New York Academy of Sciences 1989;573():347-59.
1989: T J Thekkumkara; G Pons; S Mitroo; J E Jentoft; Mulchand S Patel
Molecular biology of the human pyruvate dehydrogenase complex: structural aspects of the E2 and E3 components.
Annals of the New York Academy of Sciences 1989;573():113-29.
1988: T J Thekkumkara; L Ho; ID Wexler; G Pons; T C Liu; Mulchand S Patel
Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex.
FEBS letters 1988;240(1-2):45-8.
1988: Douglas S Kerr; S A Berry; M M Lusk; L Ho; Mulchand S Patel
A deficiency of both subunits of pyruvate dehydrogenase which is not expressed in fibroblasts.
Pediatric research 1988;24(1):95-100.
1988: G Pons; C Raefsky-Estrin; D J Carothers; R A Pepin; A A Javed; B W Jesse; M K Ganapathi; D Samols; Mulchand S Patel
Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase component human alpha-ketoacid dehydrogenase complexes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1422-6.
1988: L Ho; A A Javed; R A Pepin; T J Thekkumkara; C Raefsky; J E Mole; A M Caliendo; M S Kwon; Douglas S Kerr; Mulchand S Patel
Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex.
Biochemical and biophysical research communications 1988;150(3):904-8.
1988: D J Carothers; G Pons; Mulchand S Patel
Induction of dihydrolipoamide dehydrogenase in 3T3-L1 cells during differentiation.
The Biochemical journal 1988;249(3):897-902.
1987: M K Ganapathi; M Kwon; P M Haney; C McTiernan; A A Javed; R A Pepin; D Samols; Mulchand S Patel
Cloning of rat brain succinyl-CoA:3-oxoacid CoA-transferase cDNA. Regulation of the mRNA in different rat tissues and during brain development.
The Biochemical journal 1987;248(3):853-7.
1987: Douglas S Kerr; L Ho; C M Berlin; K F Lanoue; J Towfighi; Charles L Hoppel; M M Lusk; C M Gondek; Mulchand S Patel
Systemic deficiency of the first component of the pyruvate dehydrogenase complex.
Pediatric research 1987;22(3):312-8.
1987: D J Carothers; C Raefsky-Estrin; G Pons; Mulchand S Patel
Rat liver mitochondria contain two immunologically distinct dihydrolipoamide dehydrogenases.
Archives of biochemistry and biophysics 1987;256(2):597-605.
1987: T J Thekkumkara; B W Jesse; L Ho; C Raefsky; R A Pepin; A A Javed; G Pons; Mulchand S Patel
Isolation of a cDNA clone for the dihydrolipoamide acetyltransferase component of the human liver pyruvate dehydrogenase complex.
Biochemical and biophysical research communications 1987;145(2):903-7.
1985: Mulchand S Patel; C Raefsky; C W Hu; L Ho
Modulation by dexamethasone of the pyruvate dehydrogenase-complex activity in 3T3-L1 adipocytes.
The Biochemical journal 1985;226(2):607-11.