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Smita Patel

Research Profile

Chemicals & Drugs

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Martin R Guscott; Linda J Bristow; Karen L Hadingham; Thomas W Rosahl; Margaret S Beer; Josephine A Stanton; Frances A Bromidge; Andrew P Owens; Ian T Huscroft; Janice Myers; Nadia M J Rupniak; Smita Patel; Paul J Whiting; Peter H Hutson; Kevin C F Fone; S M Biello; Janusz J Kulagowski; George McAllister
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.
Smita Patel; Kerry L Chapman; Deborah Marston; Peter H Hutson; C Ian Ragan
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
Janine N Bresnick; Heather A Skynner; Kerry L Chapman; Andrew D Jack; Elize Zamiara; Paul Negulescu; Kevin Beaumont; Smita Patel; George McAllister
Identification of signal transduction pathways used by orphan g protein-coupled receptors.

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All Publications

2005: Martin R Guscott; Linda J Bristow; Karen L Hadingham; Thomas W Rosahl; Margaret S Beer; Josephine A Stanton; Frances A Bromidge; Andrew P Owens; Ian T Huscroft; Janice Myers; Nadia M J Rupniak; Smita Patel; Paul J Whiting; Peter H Hutson; Kevin C F Fone; S M Biello; Janusz J Kulagowski; George McAllister
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.
Neuropharmacology 2005;48(4):492-502.
2003: Smita Patel; Kerry L Chapman; Deborah Marston; Peter H Hutson; C Ian Ragan
Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
Neuropharmacology 2003;44(8):1038-46.
2003: Janine N Bresnick; Heather A Skynner; Kerry L Chapman; Andrew D Jack; Elize Zamiara; Paul Negulescu; Kevin Beaumont; Smita Patel; George McAllister
Identification of signal transduction pathways used by orphan g protein-coupled receptors.
Assay and drug development technologies 2003;1(2):239-49.
2002: Stephen R Fletcher; Frank Burkamp; Peter Blurton; Susan K F Cheng; Robert Clarkson; desmond oconnor; Daniel Spinks; Matthew Tudge; Monique B van Niel; Smita Patel; Kerry Chapman; Rose Marwood; Sara Shepheard; Graham Bentley; Gina P Cook; Linda J Bristow; José L Castro; Peter H Hutson; Angus M MacLeod
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Journal of medicinal chemistry 2002;45(2):492-503.
2001: Michael G N Russell; R J Baker; L Barden; Margaret S Beer; Linda J Bristow; Howard B Broughton; M Knowles; George McAllister; Smita Patel; José L Castro
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
Journal of medicinal chemistry 2001;44(23):3881-95.
2001: Michael Rowley; David J Hallett; Simon C Goodacre; Christopher Moyes; James Crawforth; T J Sparey; S Patel; Rose Marwood; Smita Patel; Steven Thomas; Laure Hitzel; desmond oconnor; Nicola Szeto; José L Castro; Peter H Hutson; Angus M MacLeod
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.
Journal of medicinal chemistry 2001;44(10):1603-14.
2000: James Crawforth; Simon C Goodacre; R Maxey; S Bourrain; Smita Patel; Rose Marwood; desmond oconnor; R Herbert; Peter H Hutson; Michael Rowley
3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.
Bioorganic & medicinal chemistry letters 2000;10(24):2701-3.
2000: Graeme I Stevenson; Adrian L Smith; S Lewis; S G Michie; Joseph G Neduvelil; Smita Patel; Rose Marwood; S Patel; José L Castro
2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor.
Bioorganic & medicinal chemistry letters 2000;10(24):2697-9.
2000: Adrian L Smith; Graeme I Stevenson; S Lewis; Smita Patel; José L Castro
Solid-phase synthesis of 2,3-disubstituted indoles: discovery of a novel, high-affinity, selective h5-HT2A antagonist.
Bioorganic & medicinal chemistry letters 2000;10(24):2693-6.
1999: Robert W Carling; Kevin W Moore; Christopher Moyes; E A Jones; K Bonner; F Emms; Rose Marwood; Smita Patel; S Patel; AE Fletcher; M Beer; Bindi Sohal; Andrew Pike; Paul D Leeson
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Journal of medicinal chemistry 1999;42(14):2706-15.
1999: Kevin W Moore; K Bonner; E A Jones; F Emms; Paul D Leeson; Rose Marwood; Smita Patel; S Patel; Michael Rowley; Steven Thomas; Robert W Carling
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.
Bioorganic & medicinal chemistry letters 1999;9(9):1285-90.
1999: Neil R Curtis; Janusz J Kulagowski; Paul D Leeson; Mark P Ridgill; F Emms; SB Freedman; Smita Patel; S Patel
Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.
Bioorganic & medicinal chemistry letters 1999;9(4):585-8.
1998: S Bourrain; Ian Collins; Joseph G Neduvelil; Michael Rowley; Paul D Leeson; Smita Patel; S Patel; F Emms; Rose Marwood; Kerry L Chapman; AE Fletcher; GA Showell
Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor.
Bioorganic & medicinal chemistry 1998;6(10):1731-43.
1998: Linda J Bristow; Gina P Cook; Smita Patel; Neil R Curtis; I Mawer; Janusz J Kulagowski
Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors.
Neuropharmacology 1998;37(6):793-802.
1998: Ian Collins; Michael Rowley; William B Davey; F Emms; Rose Marwood; Smita Patel; S Patel; A Fletcher; I C Ragan; Paul D Leeson; A L Scott; TP Broten
3-(1-piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels.
Bioorganic & medicinal chemistry 1998;6(6):743-53.
1998: GA Showell; F Emms; Rose Marwood; desmond oconnor; Smita Patel; Paul D Leeson
Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors.
Bioorganic & medicinal chemistry 1998;6(1):1-8.
1997: Linda J Bristow; Neil Collinson; Gina P Cook; Neil R Curtis; SB Freedman; Janusz J Kulagowski; Paul D Leeson; Smita Patel; C Ian Ragan; Mark P Ridgill; KL Saywell; mark david tricklebank
L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1256-63.
1997: Smita Patel; S Freedman; Kerry L Chapman; F Emms; AE Fletcher; M Knowles; Rose Marwood; George McAllister; Janice Myers; Neil R Curtis; Janusz J Kulagowski; Paul D Leeson; Mark P Ridgill; M Graham; S Matheson; D Rathbone; Alan P Watt; Linda J Bristow; Nadia M J Rupniak; E Baskin; Joseph J Lynch; C Ian Ragan
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
The Journal of pharmacology and experimental therapeutics 1997;283(2):636-47.
1997: José L Castro; Howard B Broughton; Michael G N Russell; D Rathbone; Alan P Watt; Richard G Ball; Kerry L Chapman; Smita Patel; Alison J Smith; George R Marshall; VG Matassa
5-(Piperidin-2-yl)- and 5-(homopiperidin-2-yl)-1,4-benzodiazepines: high-affinity, basic ligands for the cholecystokinin-B receptor.
Journal of medicinal chemistry 1997;40(16):2491-501.
1997: Michael Rowley; Ian Collins; Howard B Broughton; William B Davey; R Baker; F Emms; Rose Marwood; Smita Patel; S Patel; C Ian Ragan; SB Freedman; R Ball; Paul D Leeson
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
Journal of medicinal chemistry 1997;40(15):2374-85.
1997: Linda J Bristow; M S Kramer; Janusz J Kulagowski; Smita Patel; C Ian Ragan; G R Seabrook
Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.
Trends in pharmacological sciences 1997;18(6):186-8.
1996: Smita Patel; Peter H Hutson
Effects of galanin on 8-OH-DPAT induced decrease in body temperature and brain 5-hydroxytryptamine metabolism in the mouse.
European journal of pharmacology 1996;317(2-3):197-204.
1996: BJ Bowery; Zerin Razzaque; F Emms; Smita Patel; S Freedman; Linda J Bristow; Janusz J Kulagowski; Guy R Seabrook
Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626.
British journal of pharmacology 1996;119(7):1491-7.
1996: Smita Patel; S Patel; Rose Marwood; F Emms; D Marston; Paul D Leeson; Neil R Curtis; Janusz J Kulagowski; S B Freedman
Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor.
Molecular pharmacology 1996;50(6):1658-64.
1996: Smita Patel; K L Chapman; A J Smith; I Bailey; S B Freedman
Are radioligand antagonist/agonist binding ratios in rat pancreas predictive of functional efficacy of cholecystokinin receptor agonists and antagonists?
Regulatory peptides 1996;65(1):29-35.
1996: Michael Rowley; Howard B Broughton; Ian Collins; R Baker; F Emms; Rose Marwood; Smita Patel; S Patel; C Ian Ragan; S B Freedman; Paul D Leeson
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.
Journal of medicinal chemistry 1996;39(10):1943-5.
1996: Janusz J Kulagowski; Howard B Broughton; Neil R Curtis; I M Mawer; Mark P Ridgill; R Baker; F Emms; S B Freedman; Rose Marwood; Smita Patel; S Patel; C Ian Ragan; Paul D Leeson
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Journal of medicinal chemistry 1996;39(10):1941-2.
1996: José L Castro; R G Ball; Howard B Broughton; Michael G N Russell; D Rathbone; Alan P Watt; R Baker; Kerry L Chapman; A E Fletcher; Smita Patel; A J Smith; George R Marshall; W Ryecroft; VG Matassa
Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.
Journal of medicinal chemistry 1996;39(4):842-9.
1995: George McAllister; M R Knowles; S M Ward-Booth; H A Sinclair; Smita Patel; Rose Marwood; F Emms; S Patel; A Smith; Guy R Seabrook
Functional coupling of human D2, D3, and D4 dopamine receptors in HEK293 cells.
Journal of receptor and signal transduction research 1995;15(1-4):267-81.
1994: Nadia M J Rupniak; Smita Patel; Rose Marwood; J Webb; John R Traynor; J Elliott; S B Freedman; S R Fletcher; Raymond G Hill
Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity.
British journal of pharmacology 1994;113(4):1487-93.
1994: Smita Patel; A J Smith; Kerry L Chapman; A E Fletcher; J A Kemp; George R Marshall; Richard Hargreaves; W Ryecroft; L L Iversen; S D Iversen
Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.
Molecular pharmacology 1994;46(5):943-8.
1994: Mark G Bock; R M DiPardo; R C Newton; Jeffrey M Bergman; D F Veber; S B Freedman; A J Smith; K L Chapman; Smita Patel; J A Kemp
Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type B receptor antagonists.
Bioorganic & medicinal chemistry 1994;2(9):987-98.
1994: Guy R Seabrook; M Knowles; N Brown; J Myers; H Sinclair; Smita Patel; S B Freedman; George McAllister
Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors.
British journal of pharmacology 1994;112(3):728-34.
1994: Smita Patel; S B Freedman
The muscarinic receptor agonist L-658,903 modulates the in vivo accumulation of inositol monophosphates in mouse brain.
European journal of pharmacology 1994;267(3):329-34.
1994: A J Smith; Smita Patel; S B Freedman
Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisation.
European journal of pharmacology 1994;267(2):215-23.
1994: Guy R Seabrook; George McAllister; M R Knowles; J Myers; H Sinclair; Smita Patel; S B Freedman; J A Kemp
Depression of high-threshold calcium currents by activation of human D2 (short) dopamine receptors expressed in differentiated NG108-15 cells.
British journal of pharmacology 1994;111(4):1061-6.
1994: Smita Patel; Kerry L Chapman; A J Smith; A Heald; S B Freedman
Use of ex vivo binding to estimate brain penetration and central activity of CCK-B antagonists.
Annals of the New York Academy of Sciences 1994;713():360-3.
1994: S B Freedman; Smita Patel; A J Smith; K Chapman; A Fletcher; J A Kemp; George R Marshall; Richard Hargreaves; K Scholey; E C Mellin
A second generation of non-peptide cholecystokinin receptor antagonists and their possible therapeutic potential.
Annals of the New York Academy of Sciences 1994;713():312-8.
1994: Mark G Bock; R M DiPardo; E C Mellin; R C Newton; D F Veber; S B Freedman; A J Smith; Smita Patel; J A Kemp; George R Marshall
Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility.
Journal of medicinal chemistry 1994;37(6):722-4.
1994: Smita Patel; Kerry L Chapman; A Heald; A J Smith; S B Freedman
Measurement of central nervous system activity of systemically administered CCKB receptor antagonists by ex vivo binding.
European journal of pharmacology 1994;253(3):237-44.
1994: Guy R Seabrook; J A Kemp; S B Freedman; Smita Patel; H A Sinclair; George McAllister
Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells.
British journal of pharmacology 1994;111(2):391-3.
1994: S B Freedman; Smita Patel; Rose Marwood; F Emms; Guy R Seabrook; M R Knowles; George McAllister
Expression and pharmacological characterization of the human D3 dopamine receptor.
The Journal of pharmacology and experimental therapeutics 1994;268(1):417-26.
1992: Guy R Seabrook; Smita Patel; Rose Marwood; F Emms; M R Knowles; S B Freedman; George McAllister
Stable expression of human D3 dopamine receptors in GH4C1 pituitary cells.
FEBS letters 1992;312(2-3):123-6.
1992: Richard Hargreaves; A T McKnight; K Scholey; N R Newberry; Leslie J Street; Peter H Hutson; J E Semark; E A Harley; Smita Patel; S B Freedman
L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.
British journal of pharmacology 1992;107(2):494-501.
1992: S B Freedman; Smita Patel; E A Harley; L L Iversen; R Baker; G A Showell; J Saunders; A McKnight; N Newberry; K Scholey
L-687,306: a functionally selective and potent muscarinic M1 receptor agonist.
European journal of pharmacology 1992;215(1):135-6.
1992: G A Showell; R Baker; J Davis; Richard Hargreaves; S B Freedman; K Hoogsteen; Smita Patel; R J Snow
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.
Journal of medicinal chemistry 1992;35(5):911-6.
1992: Leslie J Street; R Baker; T Book; Austin J Reeve; J Saunders; T Willson; Rose Marwood; Smita Patel; S B Freedman
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.
Journal of medicinal chemistry 1992;35(2):295-305.
1991: G A Showell; T L Gibbons; C O Kneen; Angus M MacLeod; Kevin J Merchant; J Saunders; S B Freedman; Smita Patel; R Baker
Tetrahydropyridyloxadiazoles: semirigid muscarinic ligands.
Journal of medicinal chemistry 1991;34(3):1086-94.
1990: S B Freedman; E A Harley; Smita Patel; N R Newberry; M J Gilbert; A T McKnight; J K Tang; J J Maguire; N T Mudunkotuwa; R Baker
A novel series of non-quaternary oxadiazoles acting as full agonists at muscarinic receptors.
British journal of pharmacology 1990;101(3):575-80.
1990: S B Freedman; E A Harley; Rose Marwood; Smita Patel
In vivo characterisation of novel efficacious muscarinic receptor agonists.
European journal of pharmacology 1990;187(2):193-9.
1990: Angus M MacLeod; R Baker; S B Freedman; Smita Patel; Kevin J Merchant; M Roe; J Saunders
Synthesis and muscarinic activities of 1,2,4-thiadiazoles.
Journal of medicinal chemistry 1990;33(7):2052-9.
1989: S B Freedman; E A Harley; Smita Patel
Direct measurement of muscarinic agents in the central nervous system of mice using ex vivo binding.
European journal of pharmacology 1989;174(2-3):253-60.