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Yogesh Patel

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Rania Mouchantaf; Heather L Watt; Traian Sulea; Nabil G Seidah; Haydar Alturaihi; Yogesh C Patel; Ujendra Kumar
Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.
C G Goodyer; S I Grigorakis; Yogesh C Patel; U Kumar
Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus.
Ramesh C Patel; Daniela C Lange; Yogesh C Patel
Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes.

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All Publications

2004: Rania Mouchantaf; Heather L Watt; Traian Sulea; Nabil G Seidah; Haydar Alturaihi; Yogesh C Patel; Ujendra Kumar
Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1.
Regulatory peptides 2004;120(1-3):133-40.
2004: C G Goodyer; S I Grigorakis; Yogesh C Patel; U Kumar
Developmental changes in the expression of somatostatin receptors (1-5) in the brain, hypothalamus, pituitary and spinal cord of the human fetus.
Neuroscience 2004;125(2):441-8.
2002: Ramesh C Patel; Daniela C Lange; Yogesh C Patel
Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes.
Methods (San Diego, Calif.) 2002;27(4):340-8.
2002: José L Ramírez; Rania Mouchantaf; Ujendra Kumar; Veronica Otero-Corchon; Marcelo Rubinstein; Malcolm J Low; Yogesh C Patel
Brain somatostatin receptors are up-regulated in somatostatin-deficient mice.
Molecular endocrinology (Baltimore, Md.) 2002;16(8):1951-63.
2002: Ramesh C Patel; Ujendra Kumar; Don C Lamb; John S Eid; Magalie Rocheville; Michael Grant; Aruna Rani; Theodore Hazlett; Shutish C Patel; Enrico Gratton; Yogesh C Patel
Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3294-9.
2001: Rania Mouchantaf; Ujendra Kumar; Traian Sulea; Yogesh C Patel
A conserved alpha-helix at the amino terminus of prosomatostatin serves as a sorting signal for the regulated secretory pathway.
The Journal of biological chemistry 2001;276(28):26308-16.
2001: Malcolm J Low; Veronica Otero-Corchon; A F Parlow; J L Ramirez; Ujendra Kumar; Yogesh C Patel; Marcelo Rubinstein
Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth.
The Journal of clinical investigation 2001;107(12):1571-80.
2000: Yogesh C Patel; Shereen Ezzat; Constance L Chik; O P Rorstad; Omar Serri; Ehud Ur; G E Wilkins
Guidelines for the diagnosis and treatment of acromegaly: a Canadian perspective.
Clinical and investigative medicine. Médecine clinique et experimentale 2000;23(3):172-87.
2000: Magalie Rocheville; Daniela C Lange; Ujendra Kumar; Shutish C Patel; Ramesh C Patel; Yogesh C Patel
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.
Science (New York, N.Y.) 2000;288(5463):154-7.
2000: D Liu; G Martino; Muthusamy Thangaraju; M Sharma; F Halwani; Shi-Hsiang Shen; Yogesh C Patel; Coimbatore B Srikant
Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis.
The Journal of biological chemistry 2000;275(13):9244-50.
2000: Magalie Rocheville; Daniela C Lange; Ujendra Kumar; R Sasi; Ramesh C Patel; Yogesh C Patel
Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.
The Journal of biological chemistry 2000;275(11):7862-9.
1999: L Puebla; Rania Mouchantaf; R Sasi; S Khare; H P Bennett; S James; Yogesh C Patel
Processing of rat preprocortistatin in mouse AtT-20 cells.
Journal of neurochemistry 1999;73(3):1273-7.
1999: N Hukovic; Magalie Rocheville; Ujendra Kumar; R Sasi; S Khare; Yogesh C Patel
Agonist-dependent up-regulation of human somatostatin receptor type 1 requires molecular signals in the cytoplasmic C-tail.
The Journal of biological chemistry 1999;274(35):24550-8.
1999: Yogesh C Patel
Somatostatin and its receptor family.
Frontiers in neuroendocrinology 1999;20(3):157-98.
1999: Shutish C Patel; Subra Suresh; Ujendra Kumar; Chang-Yong Hu; Adele Cooney; E Joan Blanchette-Mackie; Edward B Neufeld; Ramesh C Patel; Roscoe O Brady; Yogesh C Patel; Peter G Pentchev; Wei-Yi Ong
Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1657-62.
1999: Ujendra Kumar; R Sasi; S Suresh; A Patel; Muthusamy Thangaraju; P Metrakos; Shutish C Patel; Yogesh C Patel
Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.
Diabetes 1999;48(1):77-85.
1999: K Sharma; Yogesh C Patel; Coimbatore B Srikant
C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.
Molecular endocrinology (Baltimore, Md.) 1999;13(1):82-90.
1998: N Hukovic; Rosemarie Panetta; Ujendra Kumar; Magalie Rocheville; Yogesh C Patel
The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.
The Journal of biological chemistry 1998;273(33):21416-22.
1998: R Sasi; L Puebla; S Khare; Yogesh C Patel
Polymorphism in the 5' flanking region of the human somatostatin receptor subtype 5.
Gene 1998;214(1-2):45-9.
1998: Anne Dutour; Ujendra Kumar; Rosemarie Panetta; L'Houcine Ouafik; Frederic Fina; R Sasi; Yogesh C Patel
Expression of somatostatin receptor subtypes in human brain tumors.
International journal of cancer. Journal international du cancer 1998;76(5):620-7.
1998: Subra Suresh; Z Yan; Ramesh C Patel; Yogesh C Patel; Shutish C Patel
Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D.
Journal of neurochemistry 1998;70(1):242-51.
1997: Yogesh C Patel; Coimbatore B Srikant
Somatostatin receptors.
Trends in endocrinology and metabolism: TEM 1997;8(10):398-405.
1997: Michael T Greenwood; N Hukovic; Ujendra Kumar; Rosemarie Panetta; S A Hjorth; Coimbatore B Srikant; Yogesh C Patel
Ligand binding pocket of the human somatostatin receptor 5: mutational analysis of the extracellular domains.
Molecular pharmacology 1997;52(5):807-14.
1997: Ujendra Kumar; D Laird; Coimbatore B Srikant; E Escher; Yogesh C Patel
Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy.
Endocrinology 1997;138(10):4473-6.
1997: Yogesh C Patel; Aristea S Galanopoulou; S N Rabbani; J L Liu; Mariella Ravazzola; Mylene Amherdt
Somatostatin-14, somatostatin-28, and prosomatostatin[1-10] are independently and efficiently processed from prosomatostatin in the constitutive secretory pathway in islet somatostatin tumor cells (1027B2).
Molecular and cellular endocrinology 1997;131(2):183-94.
1997: Yogesh C Patel
Molecular pharmacology of somatostatin receptor subtypes.
Journal of endocrinological investigation 1997;20(6):348-67.
1997: Ramesh C Patel; D Lange; W J McConathy; Yogesh C Patel; Shutish C Patel
Probing the structure of the ligand binding cavity of lipocalins by fluorescence spectroscopy.
Protein engineering 1997;10(6):621-5.
1997: Ujendra Kumar; K Asotra; Shutish C Patel; Yogesh C Patel
Expression of NMDA receptor-1 (NR1) and huntingtin in striatal neurons which colocalize somatostatin, neuropeptide Y, and NADPH diaphorase: a double-label histochemical and immunohistochemical study.
Experimental neurology 1997;145(2 Pt 1):412-24.
1996: K Sharma; Yogesh C Patel; Coimbatore B Srikant
Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.
Molecular endocrinology (Baltimore, Md.) 1996;10(12):1688-96.
1996: N Hukovic; Rosemarie Panetta; Ujendra Kumar; Yogesh C Patel
Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation.
Endocrinology 1996;137(9):4046-9.
1996: Yogesh C Patel; M Greenwood; Rosemarie Panetta; N Hukovic; S Grigorakis; L A Robertson; Coimbatore B Srikant
Molecular biology of somatostatin receptor subtypes.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):31-8.
1995: R Day; W Dong; Rosemarie Panetta; J Kraicer; Michael T Greenwood; Yogesh C Patel
Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis.
Endocrinology 1995;136(11):5232-5.
1995: Aristea S Galanopoulou; Nabil G Seidah; Yogesh C Patel
Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule.
The Biochemical journal 1995;311 ( Pt 1)():111-8.
1995: Yogesh C Patel; J L Liu; A Warszynska; G Kent; D N Papachristou; S C Patel
Differential stimulation of somatostatin but not neuropeptide Y gene expression by quinolinic acid in cultured cortical neurons.
Journal of neurochemistry 1995;65(3):998-1006.
1995: Michael T Greenwood; L A Robertson; Yogesh C Patel
Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5'-flanking promoter region.
Gene 1995;159(2):291-2.
1995: Aristea S Galanopoulou; Nabil G Seidah; Yogesh C Patel
Direct role of furin in mammalian prosomatostatin processing.
The Biochemical journal 1995;309 ( Pt 1)():33-40.
1995: J L Liu; Yogesh C Patel
Glucocorticoids inhibit somatostatin gene expression through accelerated degradation of somatostatin messenger ribonucleic acid in human thyroid medullary carcinoma (TT) cells.
Endocrinology 1995;136(6):2389-96.
1995: N Brakch; Aristea S Galanopoulou; Yogesh C Patel; Guy Boileau; Nabil G Seidah
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways.
FEBS letters 1995;362(2):143-6.
1995: Shutish C Patel; K Asotra; Yogesh C Patel; W J McConathy; Ramesh C Patel; Subra Suresh
Astrocytes synthesize and secrete the lipophilic ligand carrier apolipoprotein D.
Neuroreport 1995;6(4):653-7.
1995: Yogesh C Patel; Michael T Greenwood; Rosemarie Panetta; L Demchyshyn; Hyman B Niznik; Coimbatore B Srikant
The somatostatin receptor family.
Life sciences 1995;57(13):1249-65.
1995: Yogesh C Patel; Aristea S Galanopoulou
Processing and intracellular targeting of prosomatostatin-derived peptides: the role of mammalian endoproteases.
Ciba Foundation symposium 1995;190():26-40; discussion 40-50.
1995: Rosemarie Panetta; Yogesh C Patel
Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors.
Life sciences 1995;56(5):333-42.
1994: Michael T Greenwood; Rosemarie Panetta; L A Robertson; J L Liu; Yogesh C Patel
Sequence analysis of the 5'-flanking promoter region of the human somatostatin receptor 5.
Biochemical and biophysical research communications 1994;205(3):1883-90.
1994: Yogesh C Patel; Coimbatore B Srikant
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
Endocrinology 1994;135(6):2814-7.
1994: Shutish C Patel; K Asotra; Yogesh C Patel; Ramesh C Patel; Subra Suresh
25-Hydroxycholesterol induces reorganization of lysosomes in normal but not Niemann-Pick disease type C astrocytes.
Neuroreport 1994;5(16):2121-4.
1994: J L Liu; D N Papachristou; Yogesh C Patel
Glucocorticoids activate somatostatin gene transcription through co-operative interaction with the cyclic AMP signalling pathway.
The Biochemical journal 1994;301 ( Pt 3)():863-9.
1994: D N Papachristou; J L Liu; Yogesh C Patel
Glucocorticoids regulate somatostatin peptide and steady state messenger ribonucleic acid levels in normal rat tissues and in a somatostatin-producing islet tumor cell line (1027B2).
Endocrinology 1994;134(5):2259-66.
1994: Rosemarie Panetta; Michael T Greenwood; A Warszynska; L L Demchyshyn; R Day; Hyman B Niznik; Coimbatore B Srikant; Yogesh C Patel
Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.
Molecular pharmacology 1994;45(3):417-27.
1994: Yogesh C Patel; Michael T Greenwood; A Warszynska; Rosemarie Panetta; Coimbatore B Srikant
All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase.
Biochemical and biophysical research communications 1994;198(2):605-12.
1994: Yogesh C Patel; Rosemarie Panetta; E Escher; M Greenwood; Coimbatore B Srikant
Expression of multiple somatostatin receptor genes in AtT-20 cells. Evidence for a novel somatostatin-28 selective receptor subtype.
The Journal of biological chemistry 1994;269(2):1506-9.
1994: D N Papachristou; J L Liu; Yogesh C Patel
Cysteamine-induced reduction in tissue somatostatin immunoreactivity is associated with alterations in somatostatin mRNA.
Regulatory peptides 1994;49(3):237-47.
1993: L L Demchyshyn; Coimbatore B Srikant; Roger K Sunahara; Geraldine Kent; Philip Seeman; Hubert H M Van Tol; Rosemarie Panetta; Yogesh C Patel; Hyman B Niznik
Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.
Molecular pharmacology 1993;43(6):894-901.
1993: J D Corness; L L Demchyshyn; Philip Seeman; Hubert H M Van Tol; Coimbatore B Srikant; Geraldine Kent; Yogesh C Patel; Hyman B Niznik
A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
FEBS letters 1993;321(2-3):279-84.
1993: Yogesh C Patel; M Greenwood; Geraldine Kent; Rosemarie Panetta; Coimbatore B Srikant
Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.
Biochemical and biophysical research communications 1993;192(1):288-94.
1993: Aristea S Galanopoulou; Geraldine Kent; S N Rabbani; Nabil G Seidah; Yogesh C Patel
Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2.
The Journal of biological chemistry 1993;268(8):6041-9.
1992: Coimbatore B Srikant; K K Murthy; E E Escher; Yogesh C Patel
Photoaffinity labeling of the somatostatin receptor: identification of molecular subtypes.
Endocrinology 1992;130(5):2937-46.
1992: Coimbatore B Srikant; K K Murthy; Yogesh C Patel
Tissue-specific distribution of cross-linked somatostatin receptor proteins in the rat.
The Biochemical journal 1992;282 ( Pt 2)():339-44.
1991: Yogesh C Patel; D N Papachristou; Hans H Zingg; E M Farkas
Regulation of islet somatostatin secretion and gene expression: selective effects of adenosine 3',5'-monophosphate and phorbol esters in normal islets of Langerhans and in a somatostatin-producing rat islet clonal cell line 1027 B2.
Endocrinology 1991;128(4):1754-62.
1991: S C Patel; D N Papachristou; Yogesh C Patel
Quinolinic acid stimulates somatostatin gene expression in cultured rat cortical neurons.
Journal of neurochemistry 1991;56(4):1286-91.
1990: Yogesh C Patel; K K Murthy; E E Escher; D Banville; J Spiess; Coimbatore B Srikant
Mechanism of action of somatostatin: an overview of receptor function and studies of the molecular characterization and purification of somatostatin receptor proteins.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):63-9.
1990: K K Murthy; D Banville; Coimbatore B Srikant; France Carrier; C Holmes; A Bell; Yogesh C Patel
Structural homology between the rat calreticulin gene product and the Onchocerca volvulus antigen Ral-1.
Nucleic acids research 1990;18(16):4933.
1990: S N Rabbani; Yogesh C Patel
Peptides derived by processing of rat prosomatostatin near the amino-terminus: characterization, tissue distribution, and release.
Endocrinology 1990;126(4):2054-61.
1989: K K Murthy; Coimbatore B Srikant; Yogesh C Patel
Evidence for multiple protein constituents of the somatostatin receptor in pituitary tumor cells: affinity cross-linking and molecular characterization.
Endocrinology 1989;125(2):948-56.
1989: D N Papachristou; K Pham; Hans H Zingg; Yogesh C Patel
Tissue-specific alterations in somatostatin mRNA accumulation in streptozocin-induced diabetes.
Diabetes 1989;38(6):752-7.
1988: S N Rabbani; Yogesh C Patel
Measurement and characterization of somatostatin-14-like immunoreactivity in human urine.
The Journal of clinical endocrinology and metabolism 1988;66(5):1050-5.
1988: Yogesh C Patel; WM O'Neil
Peptides derived from cleavage of prosomatostatin at carboxyl- and amino-terminal segments. Characterization of tissue and secreted forms in the rat.
The Journal of biological chemistry 1988;263(2):745-51.
1987: M Amherdt; Yogesh C Patel; L Orci
Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography.
The Journal of clinical investigation 1987;80(5):1455-8.
1981: Yogesh C Patel; T Wheatley; C Ning
Multiple forms of immunoreactive somatostatin: comparison of distribution in neural and nonneural tissues and portal plasma of the rat.
Endocrinology 1981;109(6):1943-9.