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Alexandre Patenaude

Research Profile

Chemicals & Drugs

Anatomy

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Drug Screening Assays, Antitumor

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Publications

TOP 3
Alexandre Patenaude; Jessica S Fortin; Réna Deschenes; Marie-France Côté; Jacques Lacroix; René C-Gaudreault; Eric Petitclerc
Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocation.
Jessica S Fortin; Marie-France Côté; Jacques Lacroix; Alexandre Patenaude; Eric Petitclerc; René C-Gaudreault
Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation.
Jessica S Fortin; Jacques Lacroix; Michel Desjardins; Alexandre Patenaude; Eric Petitclerc; René C-Gaudreault
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.

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All Publications

2010: Alexandre Patenaude; Jessica S Fortin; Réna Deschenes; Marie-France Côté; Jacques Lacroix; René C-Gaudreault; Eric Petitclerc
Chloroethyl urea derivatives block tumour growth and thioredoxin-1 nuclear translocation.
Canadian journal of physiology and pharmacology 2010;88(11):1102-14.
2008: Jessica S Fortin; Marie-France Côté; Jacques Lacroix; Alexandre Patenaude; Eric Petitclerc; René C-Gaudreault
Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation.
Bioorganic & medicinal chemistry letters 2008;18(12):3526-31.
2007: Jessica S Fortin; Jacques Lacroix; Michel Desjardins; Alexandre Patenaude; Eric Petitclerc; René C-Gaudreault
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.
Bioorganic & medicinal chemistry 2007;15(13):4456-69.
2007: Sébastien Fortin; Emmanuel Moreau; Jacques Lacroix; Jean-Claude Teulade; Alexandre Patenaude; René C-Gaudreault
N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
Bioorganic & medicinal chemistry letters 2007;17(7):2000-4.
2007: Francis Cronier; Alexandre Patenaude; René C-Gaudreault; Michèle Auger
Membrane composition modulates the interaction between a new class of antineoplastic agents deriving from aromatic 2-chloroethylureas and lipid bilayers: a solid-state NMR study.
Chemistry and physics of lipids 2007;146(2):125-35.
2007: Alexandre Patenaude; Réna G Deschesnes; Jean L C Rousseau; Eric Petitclerc; Jacques Lacroix; Marie-France Côté; René C-Gaudreault
New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia.
Cancer research 2007;67(5):2306-16.
2007: Sébastien Fortin; Emmanuel Moreau; Alexandre Patenaude; Michel Desjardins; Jacques Lacroix; Jean L C Rousseau; René C-Gaudreault
N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.
Bioorganic & medicinal chemistry 2007;15(3):1430-8.
2007: Réna G Deschesnes; Alexandre Patenaude; Jean L C Rousseau; Jessica S Fortin; Christine Ricard; Marie-France Côté; Jacques Huot; René C-Gaudreault; Eric Petitclerc
Microtubule-destabilizing agents induce focal adhesion structure disorganization and anoikis in cancer cells.
The Journal of pharmacology and experimental therapeutics 2007;320(2):853-64.