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Amy Patick

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Harry L A Janssen; Sakari Kauppinen; Barney D King; Eric J Lawitz; Arthur A Levin; Keyur Patel; Amy K Patick; Robert Persson; Hendrik W Reesink; Maribel Rodriguez-Torres; Adriaan J van der Meer; Stefan Zeuzem; Yi Zhou; Alice Chen; Michael R Hodges
Treatment of HCV infection by targeting microRNA.
Joseph Binder; Wade Diehl; Laura Lingardo; Robert Love; Karen A Maegley; Amy K Patick; Selwyna Tetangco; Megan Weinshank; George J Smith
Development of hepatitis C virus chimeric replicons for identifying broad spectrum NS3 protease inhibitors.
Wade S Blair; Chris Pickford; Stephen L Irving; David Brown; Marie Anderson; Richard Bazin; Joan Cao; Giuseppe Ciaramella; Jason Isaacson; Lynn Jackson; Rachael Hunt; Anne Kjerrstrom; James A Nieman; Amy K Patick; Manos Perros; Andrew D Scott; Kevin Whitby; Hua Wu; Scott L Butler
HIV capsid is a tractable target for small molecule therapeutic intervention.

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All Publications

2013: Harry L A Janssen; Sakari Kauppinen; Barney D King; Eric J Lawitz; Arthur A Levin; Keyur Patel; Amy K Patick; Robert Persson; Hendrik W Reesink; Maribel Rodriguez-Torres; Adriaan J van der Meer; Stefan Zeuzem; Yi Zhou; Alice Chen; Michael R Hodges
Treatment of HCV infection by targeting microRNA.
The New England journal of medicine 2013;368(18):1685-94.
2011: Joseph Binder; Wade Diehl; Laura Lingardo; Robert Love; Karen A Maegley; Amy K Patick; Selwyna Tetangco; Megan Weinshank; George J Smith
Development of hepatitis C virus chimeric replicons for identifying broad spectrum NS3 protease inhibitors.
Antiviral research 2011;91(2):102-11.
2010: Wade S Blair; Chris Pickford; Stephen L Irving; David Brown; Marie Anderson; Richard Bazin; Joan Cao; Giuseppe Ciaramella; Jason Isaacson; Lynn Jackson; Rachael Hunt; Anne Kjerrstrom; James A Nieman; Amy K Patick; Manos Perros; Andrew D Scott; Kevin Whitby; Hua Wu; Scott L Butler
HIV capsid is a tractable target for small molecule therapeutic intervention.
PLoS pathogens 2010;6(12):e1001220.
2010: Jack T Nguyen; Justin D Hoopes; Minh H Le; Donald F Smee; Amy K Patick; Dennis J Faix; Patrick J Blair; Menno D De Jong; Mark Prichard; Gregory T Went
Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro.
PloS one 2010;5(2):e9332.
2009: Wade S Blair; Joan Cao; Juin Fok-Seang; Paul Griffin; Jason Isaacson; R Lynn Jackson; Edward Murray; Amy K Patick; Qinghai Peng; Manos Perros; Chris Pickford; Hua Wu; Scott L Butler
New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation.
Antimicrobial agents and chemotherapy 2009;53(12):5080-7.
2009: Stephanie T Shi; Koleen J Herlihy; Joanne P Graham; Jim Nonomiya; Sadayappan V Rahavendran; Heather Skor; Rebecca Irvine; Susan Binford; John Tatlock; Hui Li; Javier Gonzalez; Angelica Linton; Amy K Patick; Cristina Lewis
Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrobial agents and chemotherapy 2009;53(6):2544-52.
2008: Koleen J Herlihy; Joanne P Graham; Robert Kumpf; Amy K Patick; Rohit Duggal; Stephanie T Shi
Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.
Antimicrobial agents and chemotherapy 2008;52(10):3523-31.
2008: Armando De Palma; Gerhard Pürstinger; Eva Wimmer; Amy K Patick; Koen Andries; Bart Rombaut; Erik De Clercq; Johan Neyts
Potential use of antiviral agents in polio eradication.
Emerging infectious diseases 2008;14(4):545-51.
2008: Stephanie T Shi; Koleen J Herlihy; Joanne P Graham; Shella A Fuhrman; Chau Doan; Hans E Parge; Michael Hickey; Jingjin Gao; Xiu Yu; Fannie Chau; Javier Gonzalez; Hui Li; Cristina Lewis; Amy K Patick; Rohit Duggal
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrobial agents and chemotherapy 2008;52(2):675-83.
2007: Susan Binford; P T Weady; Fausto C Maldonado; Mary A Brothers; David A Matthews; Amy K Patick
In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease.
Antimicrobial agents and chemotherapy 2007;51(12):4366-73.
2007: Wade S Blair; Joan Cao; Lynn Jackson; Judith Jimenez; Qinghai Peng; Hua Wu; Jason Isaacson; Scott L Butler; Alex Chu; Joanne Graham; Anne-Marie Malfait; Micky D Tortorella; Amy K Patick
Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing.
Antimicrobial agents and chemotherapy 2007;51(10):3554-61.
2007: Weidong Hao; Koleen J Herlihy; Noelle Jie Zhang; Shella A Fuhrman; Chau Doan; Amy K Patick; Rohit Duggal
Development of a novel dicistronic reporter-selectable hepatitis C virus replicon suitable for high-throughput inhibitor screening.
Antimicrobial agents and chemotherapy 2007;51(1):95-102.
2006: Amy K Patick
Rhinovirus chemotherapy.
Antiviral research 2006;71(2-3):391-6.
2006: Akihiko Sato; Jennifer Hammond; Therese N Alexander; Joanne P Graham; Susan Binford; Ken-Ichi Sugita; Hirohiko Sugimoto; Tamio Fujiwara; Amy K Patick
In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor.
Antiviral research 2006;70(2):66-74.
2005: Joan Cao; Jason Isaacson; Amy K Patick; Wade S Blair
High-throughput human immunodeficiency virus type 1 (HIV-1) full replication assay that includes HIV-1 Vif as an antiviral target.
Antimicrobial agents and chemotherapy 2005;49(9):3833-41.
2005: Amy K Patick; Mary A Brothers; Fausto C Maldonado; Susan Binford; Oscar Maldonado; Shella A Fuhrman; Annkatrin Petersen; George J Smith; Leora S Zalman; Leigh Ann Burns-Naas; Jonathan Q Tran
In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease.
Antimicrobial agents and chemotherapy 2005;49(6):2267-75.
2005: Wade S Blair; Jason Isaacson; Xinqiang Li; Joan Cao; Qinghai Peng; George F Z Kong; Amy K Patick
A novel HIV-1 antiviral high throughput screening approach for the discovery of HIV-1 inhibitors.
Antiviral research 2005;65(2):107-16.
2005: Susan Binford; Fausto C Maldonado; Mary A Brothers; P T Weady; Leora S Zalman; James W Meador; David A Matthews; Amy K Patick
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.
Antimicrobial agents and chemotherapy 2005;49(2):619-26.
2004: Anna Ettinger; Rachel Ostroff; Marynette Rhihanek; Peter S Dragovich; Leora S Zalman; Amy K Patick; Thomas J Prins; Shella A Fuhrman; Edward L Brown; Stephen T Worland; Barry Polisky
An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents.
Antiviral research 2004;61(3):153-9.
2003: Frederick G Hayden; Ronald Turner; Jack M Gwaltney; Kathy Chi-Burris; Merril Gersten; Poe-Hirr Hsyu; Amy K Patick; George J Smith; Leora S Zalman
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
Antimicrobial agents and chemotherapy 2003;47(12):3907-16.
2002: Theodore O Johnson; Ye Hua; Hiep T Luu; Edward L Brown; Fora Chan; Shao Song Chu; Peter S Dragovich; Brian W Eastman; Rose Ann Ferre; Shella A Fuhrman; Thomas F Hendrickson; Fausto C Maldonado; David A Matthews; James W Meador; Amy K Patick; Siegfried H Reich; Donald J Skalitzky; Stephen T Worland; Michelle Yang; Leora S Zalman
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.
Journal of medicinal chemistry 2002;45(10):2016-23.
2002: Peter S Dragovich; Thomas J Prins; Ru Zhou; Edward L Brown; Fausto C Maldonado; Shella A Fuhrman; Leora S Zalman; Tove tuntland; Caroline A Lee; Amy K Patick; David A Matthews; Thomas F Hendrickson; Maha B Kosa; Bo Liu; Minerva R Batugo; Jean-Paul R Gleeson; Sylvie K Sakata; Lijian Chen; Mark C Guzman; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
Journal of medicinal chemistry 2002;45(8):1607-23.
2002: Peter S Dragovich; Thomas J Prins; Ru Zhou; Theodore O Johnson; Edward L Brown; Fausto C Maldonado; Shella A Fuhrman; Leora S Zalman; Amy K Patick; David A Matthews; Xinjun Hou; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.
Bioorganic & medicinal chemistry letters 2002;12(5):733-8.
2001: Stephen E Webber; Joseph T Marakovits; Peter S Dragovich; Thomas J Prins; Ru Zhou; Shella A Fuhrman; Amy K Patick; David A Matthews; Caroline A Lee; B Srinivasan; T Moran; CE Ford; Mary A Brothers; JE Harr; James W Meador; Rose Ann Ferre; Stephen T Worland
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(20):2683-6.
2001: Rachel Ostroff; Anna Ettinger; H La; M Rihanek; Leora S Zalman; James W Meador; Amy K Patick; Stephen T Worland; Barry Polisky
Rapid multiserotype detection of human rhinoviruses on optically coated silicon surfaces.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2001;21(2):105-17.
2001: Kanyin E Zhang; E Wu; Amy K Patick; B Kerr; Mark Zorbas; A Lankford; T Kobayashi; Y Maeda; Bhasker Shetty; Stephanie Webber
Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities.
Antimicrobial agents and chemotherapy 2001;45(4):1086-93.
2000: B Atkinson; Jason Isaacson; M Knowles; E Mazabel; Amy K Patick
Correlation between human immunodeficiency virus genotypic resistance and virologic response in patients receiving nelfinavir monotherapy or nelfinavir with lamivudine and zidovudine.
The Journal of infectious diseases 2000;182(2):420-7.
2000: Siegfried H Reich; T Johnson; MB Wallace; S E Kephart; Shella A Fuhrman; Stephen T Worland; David A Matthews; Thomas F Hendrickson; F Chan; James W Meador; Rose Ann Ferre; Edward L Brown; DM DeLisle; Amy K Patick; Susan Binford; CE Ford
Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation.
Journal of medicinal chemistry 2000;43(9):1670-83.
2000: Leora S Zalman; Mary A Brothers; Peter S Dragovich; Ru Zhou; Thomas J Prins; Stephen T Worland; Amy K Patick
Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor.
Antimicrobial agents and chemotherapy 2000;44(5):1236-41.
2000: Peter S Dragovich; Ru Zhou; Stephen E Webber; Thomas J Prins; A K Kwok; K Okano; Shella A Fuhrman; Leora S Zalman; Fausto C Maldonado; Edward L Brown; James W Meador; Amy K Patick; CE Ford; Mary A Brothers; Susan Binford; David A Matthews; Rose Ann Ferre; Stephen T Worland
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(1):45-8.
1999: Amy K Patick; Susan Binford; Mary A Brothers; R L Jackson; CE Ford; M D Diem; Fausto C Maldonado; Peter S Dragovich; Ru Zhou; Thomas J Prins; Shella A Fuhrman; James W Meador; Leora S Zalman; David A Matthews; Stephen T Worland
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.
Antimicrobial agents and chemotherapy 1999;43(10):2444-50.
1999: David A Matthews; Peter S Dragovich; Stephen E Webber; Shella A Fuhrman; Amy K Patick; Leora S Zalman; Thomas F Hendrickson; Robert A Love; Thomas J Prins; Joseph T Marakovits; Ru Zhou; Jayashree G Tikhe; CE Ford; James W Meador; Rose Ann Ferre; Edward L Brown; Susan Binford; Mary A Brothers; DM DeLisle; Stephen T Worland
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11000-7.
1999: Peter S Dragovich; Stephen E Webber; Thomas J Prins; Ru Zhou; Joseph T Marakovits; Jayashree G Tikhe; Shella A Fuhrman; Amy K Patick; David A Matthews; CE Ford; Edward L Brown; Susan Binford; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids.
Bioorganic & medicinal chemistry letters 1999;9(15):2189-94.
1999: Peter S Dragovich; Thomas J Prins; Ru Zhou; Stephen E Webber; Joseph T Marakovits; Shella A Fuhrman; Amy K Patick; David A Matthews; Caroline A Lee; CE Ford; B J Burke; Paul Rejto; Thomas F Hendrickson; Tove tuntland; Edward L Brown; James W Meador; Rose Ann Ferre; JE Harr; Maha B Kosa; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Journal of medicinal chemistry 1999;42(7):1213-24.
1999: Peter S Dragovich; Thomas J Prins; Ru Zhou; Shella A Fuhrman; Amy K Patick; David A Matthews; CE Ford; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
Journal of medicinal chemistry 1999;42(7):1203-12.
1999: Peter S Dragovich; Ru Zhou; Donald J Skalitzky; Shella A Fuhrman; Amy K Patick; CE Ford; James W Meador; Stephen T Worland
Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides.
Bioorganic & medicinal chemistry 1999;7(4):589-98.
1998: Amy K Patick; K E Potts
Protease inhibitors as antiviral agents.
Clinical microbiology reviews 1998;11(4):614-27.
1998: Amy K Patick; M Duran; Y Cao; D Shugarts; M R Keller; E Mazabel; M Knowles; S Chapman; D R Kuritzkes; M Markowitz
Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir.
Antimicrobial agents and chemotherapy 1998;42(10):2637-44.
1998: Peter S Dragovich; Stephen E Webber; R E Babine; Shella A Fuhrman; Amy K Patick; David A Matthews; Siegfried H Reich; Joseph T Marakovits; Thomas J Prins; Ru Zhou; Jayashree G Tikhe; E S Littlefield; T M Bleckman; MB Wallace; T L Little; CE Ford; James W Meador; Rose Ann Ferre; Edward L Brown; Susan Binford; DM DeLisle; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies.
Journal of medicinal chemistry 1998;41(15):2819-34.
1998: Peter S Dragovich; Stephen E Webber; R E Babine; Shella A Fuhrman; Amy K Patick; David A Matthews; Caroline A Lee; Siegfried H Reich; Thomas J Prins; Joseph T Marakovits; E S Littlefield; Ru Zhou; Jayashree G Tikhe; CE Ford; MB Wallace; James W Meador; Rose Ann Ferre; Edward L Brown; Susan Binford; JE Harr; DM DeLisle; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.
Journal of medicinal chemistry 1998;41(15):2806-18.
1998: Stephen E Webber; K Okano; T L Little; Siegfried H Reich; Y Xin; Shella A Fuhrman; David A Matthews; Robert A Love; Thomas F Hendrickson; Amy K Patick; James W Meador; Rose Ann Ferre; Edward L Brown; CE Ford; Susan Binford; Stephen T Worland
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
Journal of medicinal chemistry 1998;41(15):2786-805.
1997: Stephen W Kaldor; V J Kalish; J F Davies; Bhasker Shetty; JE Fritz; K Appelt; J A Burgess; K M Campanale; Nikolay Y Chirgadze; David Clawson; B A Dressman; S D Hatch; D A Khalil; Maha B Kosa; P P Lubbehusen; M A Muesing; Amy K Patick; Siegfried H Reich; K S Su; J H Tatlock
Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.
Journal of medicinal chemistry 1997;40(24):3979-85.
1997: Amy K Patick; T J Boritzki; L A Bloom
Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro.
Antimicrobial agents and chemotherapy 1997;41(10):2159-64.
1997: T K Huffaker; Susan Binford; Amy K Patick; C Pinko; CC Kan; Leora S Zalman
Comparison of human cytomegalovirus (HCMV) protease sequences among laboratory strains and seven clinical isolates.
Antiviral research 1997;33(3):215-8.
1996: Stephen E Webber; Jayashree G Tikhe; Stephen T Worland; Shella A Fuhrman; Thomas F Hendrickson; David A Matthews; Robert A Love; Amy K Patick; James W Meador; Rose Ann Ferre; Edward L Brown; DM DeLisle; CE Ford; Susan Binford
Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.
Journal of medicinal chemistry 1996;39(26):5072-82.
1996: Amy K Patick; H Mo; Martin Markowitz; Krzysztof Appelt; B Wu; L Musick; V Kalish; S Kaldor; S Reich; D Ho; S Webber
Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease.
Antimicrobial agents and chemotherapy 1996;40(2):292-7.