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Kennerly Patrick

Research Profile

Chemicals & Drugs

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TOP 3
William C Griffin; Robin W McGovern; Lawrence D Middaugh; Guinevere H Bell; Patrick K Randall; Kennerly S Patrick
Interactive effects of methylphenidate and alcohol on discrimination, conditioned place preference and motor coordination in C57BL/6J mice.
Kennerly S Patrick; Owen T Reeves; Arthur B Straughn; Erica R Anderson; Guinevere H Bell; Hilary Bernstein; Robert J Malcolm
Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans.
Guinevere H Bell; William C Griffin; Kennerly S Patrick
Oral and transdermal DL-methylphenidate-ethanol interactions in C57BL/6J mice: potentiation of locomotor activity with oral delivery.

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All Publications

2013: William C Griffin; Robin W McGovern; Lawrence D Middaugh; Guinevere H Bell; Patrick K Randall; Kennerly S Patrick
Interactive effects of methylphenidate and alcohol on discrimination, conditioned place preference and motor coordination in C57BL/6J mice.
Psychopharmacology 2013;225(3):613-25.
2013: Kennerly S Patrick; Owen T Reeves; Arthur B Straughn; Erica R Anderson; Guinevere H Bell; Hilary Bernstein; Robert J Malcolm
Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(1):197-205.
2011: Guinevere H Bell; William C Griffin; Kennerly S Patrick
Oral and transdermal DL-methylphenidate-ethanol interactions in C57BL/6J mice: potentiation of locomotor activity with oral delivery.
Pharmacology, biochemistry, and behavior 2011;100(2):264-70.
2011: Guinevere H Bell; Andrew J Novak; William C Griffin; Kennerly S Patrick
Transdermal and oral dl-methylphenidate-ethanol interactions in C57BL/6J mice: transesterification to ethylphenidate and elevation of d-methylphenidate concentrations.
Journal of pharmaceutical sciences 2011;100(7):2966-78.
2011: Hao-Jie Zhu; Kennerly S Patrick; John S Markowitz
Enantiospecific determination of DL-methylphenidate and DL-ethylphenidate in plasma by liquid chromatography-tandem mass spectrometry: application to human ethanol interactions.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(11-12):783-8.
2010: William C Griffin; Andrew J Novak; Lawrence D Middaugh; Kennerly S Patrick
The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice.
Pharmacology, biochemistry, and behavior 2010;95(3):267-72.
2009: Kennerly S Patrick; Arthur B Straughn; Jeb S Perkins; Mario A González
Evolution of stimulants to treat ADHD: transdermal methylphenidate.
Human psychopharmacology 2009;24(1):1-17.
2008: Hao-Jie Zhu; Kennerly S Patrick; Hong-Jie Yuan; Jun-Sheng Wang; Jennifer L Donovan; C Lindsay DeVane; Robert Malcolm; Julie A Johnson; Geri L Youngblood; Douglas H Sweet; Taimour Y Langaee; Hao-Jie Zhu
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.
American journal of human genetics 2008;82(6):1241-8.
2008: John S Markowitz; Kennerly S Patrick
Differential pharmacokinetics and pharmacodynamics of methylphenidate enantiomers: does chirality matter?
Journal of clinical psychopharmacology 2008;28(3 Suppl 2):S54-61.
2008: John S Markowitz; Kennerly S Patrick
Given the multifaceted nature of ADHD, namely its physiologic, cognitive, psychological, and behavioral manifestations, multimodal approaches to treatment are advocated. Introduction.
Journal of clinical psychopharmacology 2008;28(3 Suppl 2):S37-8.
2008: Natalie L LeVasseur; Hao-Jie Zhu; John S Markowitz; C Lindsay DeVane; Kennerly S Patrick
Enantiospecific gas chromatographic-mass spectrometric analysis of urinary methylphenidate: implications for phenotyping.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;862(1-2):140-9.
2007: Hao-Jie Zhu; Jun-Sheng Wang; Kennerly S Patrick; Jennifer L Donovan; C Lindsay DeVane; Hao-Jie Zhu
A novel HPLC fluorescence method for the quantification of methylphenidate in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;858(1-2):91-5.
2007: Ram P Gupta; Kennerly S Patrick; Norman H Bell
Mutational analysis of CYP27A1: assessment of 27-hydroxylation of cholesterol and 25-hydroxylation of vitamin D.
Metabolism: clinical and experimental 2007;56(9):1248-55.
2007: Heather A Boger; Lawrence D Middaugh; Kennerly S Patrick; Sammanda Ramamoorthy; Emily D Denehy; Hao-Jie Zhu; Alejandra M Pacchioni; Ann-Charlotte E. Granholm-Bentley; Jacqueline McGinty
Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(33):8816-25.
2007: Gilbert R Kinsey; Jane McHowat; Kennerly S Patrick; Rick G Schnellmann
Role of Ca2+-independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition.
The Journal of pharmacology and experimental therapeutics 2007;321(2):707-15.
2007: Kennerly S Patrick; Arthur B Straughn; R R Minhinnett; Sharon D. Yeatts; Amy E Herrin; C Lindsay DeVane; Robert Malcolm; G C Janis; John S Markowitz
Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics.
Clinical pharmacology and therapeutics 2007;81(3):346-53.
2007: Robin L Williard; Lawrence D Middaugh; Hao-Jie Zhu; Kennerly S Patrick
Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity.
Behavioural pharmacology 2007;18(1):39-51.
2006: John S Markowitz; C Lindsay DeVane; Linda Pestreich; Kennerly S Patrick; Rafael Muniz
A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study.
Journal of child and adolescent psychopharmacology 2006;16(6):687-98.
2006: Hao-Jie Zhu; Jun-Sheng Wang; C Lindsay DeVane; Robin L Williard; Jennifer L Donovan; Lawrence D Middaugh; Bryan B Gibson; Kennerly S Patrick; Hao-Jie Zhu
The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(7):1116-21.
2005: Chinedu J Njoku; Kennerly S Patrick; Phillip Ruiz; Jim Oates
Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2005;53(7):347-52.
2005: Jennifer L Donovan; C Lindsay DeVane; Kenneth D Chavin; Jim Oates; Chinedu J Njoku; Kennerly S Patrick; Ryan N Fiorini; John S Markowitz
Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F(2 alpha), a biomarker for in-vivo lipid peroxidation.
The Journal of pharmacy and pharmacology 2005;57(10):1365-9.
2005: Kennerly S Patrick; Robin L Williard; Adam L VanWert; Justin J Dowd; John E Oatis; Lawrence D Middaugh
Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol.
Journal of medicinal chemistry 2005;48(8):2876-81.
2005: Mehrdad Rahmaniyan; Kennerly S Patrick; Norman H Bell
Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase.
American journal of physiology. Endocrinology and metabolism 2005;288(4):E753-60.
2005: Ram P Gupta; You Ai He; Kennerly S Patrick; James Halpert; Norman H Bell
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.
The Journal of clinical endocrinology and metabolism 2005;90(2):1210-9.
2005: Kennerly S Patrick; Mario A González; Arthur B Straughn; John S Markowitz
New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder.
Expert opinion on drug delivery 2005;2(1):121-43.
2004: Ram P Gupta; Bruce W Hollis; Shailendra Patel; Kennerly S Patrick; Norman H Bell
CYP3A4 is a human microsomal vitamin D 25-hydroxylase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(4):680-8.
2003: John S Markowitz; Arthur B Straughn; Kennerly S Patrick
Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations.
Pharmacotherapy 2003;23(10):1281-99.
2003: John S Markowitz; Arthur B Straughn; Kennerly S Patrick; C Lindsay DeVane; Linda Pestreich; James Lee; Yanfeng Wang; Rafael Muniz
Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults.
Clinical pharmacokinetics 2003;42(4):393-401.
2001: M W Wagner; John S Markowitz; Kennerly S Patrick
Methylphenidate ER tablet lodging in esophagus.
Journal of the American Academy of Child and Adolescent Psychiatry 2001;40(11):1244-5.
2001: John S Markowitz; Kennerly S Patrick
Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder.
Clinical pharmacokinetics 2001;40(10):753-72.
2000: L T Nguyen; Murali Ramanathan; B Weinstock-Guttman; K Dole; C Miller; M Planter; Kennerly S Patrick; Carol Brownscheidle; Lawrence D Jacobs
Detection of cytochrome P450 and other drug-metabolizing enzyme mRNAs in peripheral blood mononuclear cells using DNA arrays.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(8):987-93.
2000: John S Markowitz; C Lindsay DeVane; David W Boulton; Ziad Nahas; S Craig Risch; F Diamond; Kennerly S Patrick
Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(6):620-4.
2000: Marvin C Meyer; Arthur B Straughn; E J Jarvi; Kennerly S Patrick; F R Pelsor; Roger L Williams; Rabi Patnaik; Mei-Ling Chen; Vinod P Shah
Bioequivalence of methylphenidate immediate-release tablets using a replicated study design to characterize intrasubject variability.
Pharmaceutical research 2000;17(4):381-4.
1999: SC Harvey; C P Toussaint; S E Coe; E E Watson; MG O'Neil; Kennerly S Patrick
Stability of meperidine in an implantable infusion pump using capillary gas chromatography-mass spectrometry and a deuterated internal standard.
Journal of pharmaceutical and biomedical analysis 1999;21(3):577-83.
1999: John S Markowitz; B K Logan; F Diamond; Kennerly S Patrick
Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.
Journal of clinical psychopharmacology 1999;19(4):362-6.
1998: John S Markowitz; Kennerly S Patrick
Venlafaxine-tramadol similarities.
Medical hypotheses 1998;51(2):167-8.
1997: Kennerly S Patrick; John S Markowitz
Potential for overestimation of clozapine concentrations.
Journal of analytical toxicology 1997;21(1):73-5.
1996: Lawrence D Middaugh; W O Boggan; S A Bingel; Kennerly S Patrick; W Xu
A murine model of prenatal cocaine exposure: effects on the mother and the fetus.
Pharmacology, biochemistry, and behavior 1996;55(4):565-74.
1996: S R Miller; Lawrence D Middaugh; W O Boggan; Kennerly S Patrick
Cocaine concentrations in fetal C57BL/6 mouse brain relative to maternal brain and plasma.
Neurotoxicology and teratology 1996;18(6):645-9.
1995: M Froimowitz; Kennerly S Patrick; Vivian Cody
Conformational analysis of methylphenidate and its structural relationship to other dopamine reuptake blockers such as CFT.
Pharmaceutical research 1995;12(10):1430-4.
1995: A L Salo; Carrie L Randall; Howard C Becker; Kennerly S Patrick
Acute gestational cocaine exposure alone or in combination with low-dose ethanol does not influence prenatal mortality or fetal weight in mice.
Neurotoxicology and teratology 1995;17(5):577-81.
1995: John S Markowitz; Kennerly S Patrick
Thermal degradation of clozapine-N-oxide to clozapine during gas chromatographic analysis.
Journal of chromatography. B, Biomedical applications 1995;668(1):171-4.
1995: S E Howell; S R Miller; J D McCallister; S C Cherkofsky; Kennerly S Patrick
Gas chromatographic-mass spectrometric determination of urinary 1-aminocyclopropanecarboxylic acid in mice using a deuterated internal standard.
Journal of chromatography. B, Biomedical applications 1995;663(1):148-52.
1994: Carrie L Randall; A L Salo; Howard C Becker; Kennerly S Patrick
Cocaine does not influence the teratogenic effects of acute ethanol in mice.
Reproductive toxicology (Elmsford, N.Y.) 1994;8(4):341-50.
1994: S R Miller; A L Salo; W O Boggan; Kennerly S Patrick
Determination of plasma cocaine and ethylcocaine (cocaethylene) in mice using gas chromatography-mass spectrometry and deuterated internal standards.
Journal of chromatography. B, Biomedical applications 1994;656(2):335-41.
1993: Kennerly S Patrick; W O Boggan; S R Miller; Lawrence D Middaugh
Gas chromatographic-mass spectrometric determination of plasma and brain cocaine in mice.
Journal of chromatography 1993;621(1):89-94.
1992: Kennerly S Patrick; B L Nguyen; J D McCallister
Gas chromatographic-mass spectrometric determination of plasma selegiline using a deuterated internal standard.
Journal of chromatography 1992;583(2):254-8.
1991: D A Eckerman; Sheryl S Moy; A N Perkins; Kennerly S Patrick; George R Breese
Enantioselective behavioral effects of threo-methylphenidate in rats.
Pharmacology, biochemistry, and behavior 1991;40(4):875-80.
1990: B K Logan; Kennerly S Patrick
Photodegradation of nifedipine relative to nitrendipine evaluated by liquid and gas chromatography.
Journal of chromatography 1990;529(1):175-81.
1990: Kennerly S Patrick; E J Jarvi
Capillary gas chromatographic-mass spectrometric analysis of plasma methylphenidate.
Journal of chromatography 1990;528(1):214-21.
1990: EF Huget; Kennerly S Patrick; L J Nunez
Observations on the elastic behavior of a synthetic orthodontic elastomer.
Journal of dental research 1990;69(2):496-501.
1989: Kennerly S Patrick; E J Jarvi; Arthur B Straughn; Marvin C Meyer
Gas chromatographic-mass spectrometric analysis of plasma nifedipine.
Journal of chromatography 1989;495():123-30.
1989: Kennerly S Patrick; Arthur B Straughn; E J Jarvi; George R Breese; Marvin C Meyer
The absorption of sustained-release methylphenidate formulations compared to an immediate-release formulation.
Biopharmaceutics & drug disposition 1989;10(2):165-71.
1989: Kennerly S Patrick; John S Markowitz; E J Jarvi; Arthur B Straughn; Marvin C Meyer
Gas chromatographic-mass spectrometric analysis of plasma oxybutynin using a deuterated internal standard.
Journal of chromatography 1989;487(1):91-8.
1987: Kennerly S Patrick; Robert W Caldwell; R M Ferris; George R Breese
Pharmacology of the enantiomers of threo-methylphenidate.
The Journal of pharmacology and experimental therapeutics 1987;241(1):152-8.
1985: Kennerly S Patrick; K R Ellington; George R Breese; Clinton D Kilts
Gas chromatographic-mass spectrometric analysis of methylphenidate and p-hydroxymethylphenidate using deuterated internal standards.
Journal of chromatography 1985;343(2):329-38.
1984: D E Hernandez; J W Adcock; Roy C Orlando; Kennerly S Patrick; Charles Nemeroff; A J Prange
Prevention of stress-induced gastric ulcers by dopamine agonists in the rat.
Life sciences 1984;35(24):2453-8.
1984: Kennerly S Patrick; K R Ellington; George R Breese
Distribution of methylphenidate and p-hydroxymethylphenidate in rats.
The Journal of pharmacology and experimental therapeutics 1984;231(1):61-5.
1984: C T Gualtieri; R E Hicks; Kennerly S Patrick; Stephen R Schroeder; George R Breese
Clinical correlates of methylphenidate blood levels.
Therapeutic drug monitoring 1984;6(4):379-92.
1983: W Wargin; Kennerly S Patrick; Clinton D Kilts; C T Gualtieri; K Ellington; Robert A Mueller; G Kraemer; George R Breese
Pharmacokinetics of methylphenidate in man, rat and monkey.
The Journal of pharmacology and experimental therapeutics 1983;226(2):382-6.
1981: Kennerly S Patrick; Clinton D Kilts; George R Breese
Synthesis and pharmacology of hydroxylated metabolites of methylphenidate.
Journal of medicinal chemistry 1981;24(10):1237-40.