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Philip Patsalos

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TOP 3
Philip N Patsalos; Dave J Berry
Therapeutic drug monitoring of antiepileptic drugs by use of saliva.
Cecilie Johannessen Landmark; Philip N Patsalos
Methodologies used to identify and characterize interactions among antiepileptic drugs.
Philip N Patsalos; David J Berry
Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate.

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All Publications

2013: Philip N Patsalos; Dave J Berry
Therapeutic drug monitoring of antiepileptic drugs by use of saliva.
Therapeutic drug monitoring 2013;35(1):4-29.
2012: Cecilie Johannessen Landmark; Philip N Patsalos
Methodologies used to identify and characterize interactions among antiepileptic drugs.
Expert review of clinical pharmacology 2012;5(3):281-92.
2012: Philip N Patsalos; David J Berry
Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate.
Expert opinion on pharmacotherapy 2012;13(5):699-715.
2012: Frank Mc Besag; Philip N Patsalos
New developments in the treatment of partial-onset epilepsy.
Neuropsychiatric disease and treatment 2012;8():455-64.
2011: Clare Greenaway; Neville Ratnaraj; Josemir W. Sander; Philip N Patsalos
Saliva and serum lacosamide concentrations in patients with epilepsy.
Epilepsia 2011;52(2):258-63.
2011: Jan Novy; Philip N Patsalos; Josemir W. Sander; Sanjay M Sisodiya
Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: a pharmacodynamic interaction?
Epilepsy & behavior : E&B 2011;20(1):20-3.
2010: Alan W C Yuen; Gail S Bell; Janet L Peacock; Matthias Koepp; Philip N Patsalos; Josemir W Sander
Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR.
Epilepsy research 2010;91(2-3):187-92.
2010: Karolina Stepien; Michal K Trojnar; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model.
Epilepsy research 2010;90(3):188-98.
2010: Clare Greenaway; Neville Ratnaraj; Josemir W Sander; Philip N Patsalos
A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsy.
Therapeutic drug monitoring 2010;32(4):448-52.
2010: Cecilie Johannessen Landmark; Philip N Patsalos
Drug interactions involving the new second- and third-generation antiepileptic drugs.
Expert review of neurotherapeutics 2010;10(1):119-40.
2009: Monika Dudra-Jastrzebska; Marta M Andres-Mach; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar; Karolina Stepien
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Seizure : the journal of the British Epilepsy Association 2009;18(9):607-14.
2009: Ewa Wojda; Aleksandra Wlaz; Philip N Patsalos; Karolina Stepien
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Epilepsy research 2009;86(2-3):163-74.
2009: Magdalena Chrościńska-Krawczyk; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures.
Pharmacological reports : PR 2009;61(5):819-26.
2009: Monika Dudra-Jastrzebska; Marta M Andres-Mach; Marcin Sielski; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar; Karolina Stepien
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
European journal of pharmacology 2009;605(1-3):87-94.
2009: Rafal M Kaminski; Alain Matagne; Philip N Patsalos; Henrik Klitgaard
Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam.
Epilepsia 2009;50(3):387-97.
2009: Xin Tong; Neville Ratnaraj; Philip N Patsalos
Vigabatrin extracellular pharmacokinetics and concurrent gamma-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis.
Epilepsia 2009;50(2):174-83.
2008: Karolina Stepien; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
European journal of pharmacology 2008;595(1-3):13-21.
2008: Philip N Patsalos; David J Berry; Blaise F D Bourgeois; James C Cloyd; Tracy A Glauser; Svein I Johannessen; Ilo E Leppik; Torbjörn Tomson; Emilio Perucca
Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies.
Epilepsia 2008;49(7):1239-76.
2008: Alan W C Yuen; Josemir W. Sander; Dominique Flugel; Philip N Patsalos; Lucy Browning; Gail S Bell; Matthias Koepp
Erythrocyte and plasma fatty acid profiles in patients with epilepsy: does carbamazepine affect omega-3 fatty acid concentrations?
Epilepsy & behavior : E&B 2008;12(2):317-23.
2007: Kinga K Borowicz; Robert Malek; Karolina Stepien; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Epilepsy & behavior : E&B 2007;11(1):6-12.
2007: Karolina Stepien; Marta M Andres-Mach; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model.
Epilepsia 2007;48(4):806-15.
2007: Kinga K Borowicz; Karolina Stepien; Grzegorz Sobieszek; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test model.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(4):265-72.
2007: Kinga K Borowicz; Zaneta Kimber-Trojnar; Neville Ratnaraj; Philip N Patsalos; Karolina Stepien; Stanislaw J Czuczwar
Isobolographic analysis of interactions between losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(2):94-101.
2007: X Tong; Neville Ratnaraj; Philip N Patsalos
The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluid.
Seizure : the journal of the British Epilepsy Association 2007;16(1):43-9.
2006: M-A S Y Wright; Michael Orth; Philip N Patsalos; S J M Smith; Mark P Richardson
Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients.
Neurology 2006;67(9):1646-51.
2006: Karolina Stepien; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Epilepsia 2006;47(11):1841-54.
2006: Philip N Patsalos; Sandirup Ghattaura; Neville Ratnaraj; Josemir W. Sander
In situ metabolism of levetiracetam in blood of patients with epilepsy.
Epilepsia 2006;47(11):1818-21.
2006: Martin Tisdall; Salvatore Russo; Jon Sen; Antonio Belli; N Ratnaraj; Philip N Patsalos; Axel Petzold; Neil D Kitchen; Martin Smith
Free phenytoin concentration measurement in brain extracellular fluid: a pilot study.
British journal of neurosurgery 2006;20(5):285-9.
2006: Karolina Stepien; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Naunyn-Schmiedeberg's archives of pharmacology 2006;373(2):169-81.
2006: Karolina Stepien; Marta M Andres; Piotr Czuczwar; Anna Cioczek-Czuczwar; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis.
Epilepsia 2006;47(1):10-20.
2005: Karolina Stepien; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Epilepsy & behavior : E&B 2005;7(4):639-51.
2005: Karolina Stepien; Marta M Andres; Piotr Czuczwar; Anna Cioczek-Czuczwar; Joanna Wojcik-Cwikla; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2005;15(6):609-16.
2005: Alan W C Yuen; Josemir W. Sander; Dominique Fluegel; Philip N Patsalos; Gail S Bell; Tony Johnson; Matthias Koepp
Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial.
Epilepsy & behavior : E&B 2005;7(2):253-8.
2005: Karolina Stepien; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure model.
Epilepsia 2005;46(3):344-55.
2005: Michael Orth; B Amann; Neville Ratnaraj; Philip N Patsalos; John C Rothwell
Caffeine has no effect on measures of cortical excitability.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2005;116(2):308-14.
2005: Philip N Patsalos
Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies.
Epilepsia 2005;46 Suppl 9():140-8.
2004: Regina Katzenschlager; Andrew Evans; Alice J Manson; Philip N Patsalos; Neville Ratnaraj; H Watt; L Timmermann; R Van der Giessen; Andrew J Lees
Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study.
Journal of neurology, neurosurgery, and psychiatry 2004;75(12):1672-7.
2004: Xiaolan Wang; Neville Ratnaraj; Philip N Patsalos
The pharmacokinetic inter-relationship of tiagabine in blood, cerebrospinal fluid and brain extracellular fluid (frontal cortex and hippocampus).
Seizure : the journal of the British Epilepsy Association 2004;13(8):574-81.
2004: Andrew Fisher; Xiaolan Wang; Hannah R Cock; Maria Thom; Philip N Patsalos; Matthew C Walker
Synergism between topiramate and budipine in refractory status epilepticus in the rat.
Epilepsia 2004;45(11):1300-7.
2004: Kinga K Borowicz; Neville Ratnaraj; Philip N Patsalos; Stanislaw J Czuczwar
Effect of felbamate and its combinations with conventional antiepileptics in amygdala-kindled rats.
Pharmacology, biochemistry, and behavior 2004;78(1):103-10.
2004: Philip N Patsalos
Clinical pharmacokinetics of levetiracetam.
Clinical pharmacokinetics 2004;43(11):707-24.
2003: Xiaolan Wang; Philip N Patsalos
A comparison of central brain (cerebrospinal and extracellular fluids) and peripheral blood kinetics of phenytoin after intravenous phenytoin and fosphenytoin.
Seizure : the journal of the British Epilepsy Association 2003;12(6):330-6.
2003: Philip N Patsalos; Emilio Perucca
Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs.
Lancet neurology 2003;2(8):473-81.
2003: Graeme J Sills; Elaine Butler; Gerard Forrest; Neville Ratnaraj; Philip N Patsalos; Martin J Brodie
Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina.
Epilepsia 2003;44(7):886-92.
2003: Philip N Patsalos; Emilio Perucca
Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs.
Lancet neurology 2003;2(6):347-56.
2003: Svein I Johannessen; Dina Battino; David J Berry; Meir Bialer; Günter Krämer; Torbjörn Tomson; Philip N Patsalos
Therapeutic drug monitoring of the newer antiepileptic drugs.
Therapeutic drug monitoring 2003;25(3):347-63.
2003: Andrew Fisher; Joanna zakrzewska; Philip N Patsalos
Trigeminal neuralgia: current treatments and future developments.
Expert opinion on emerging drugs 2003;8(1):123-43.
2003: Philip N Patsalos
The pharmacokinetic characteristics of levetiracetam.
Methods and findings in experimental and clinical pharmacology 2003;25(2):123-9.
2003: Sambit Sen; Neville Ratnaraj; Nathan A Davies; Rajeshwar P Mookerjee; Chris E Cooper; Philip N Patsalos; Roger Williams; Rajiv Jalan
Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS).
Epilepsia 2003;44(2):265-7.
2003: Yvonne M Langan; Richard Lucas; Haley Jewell; N Toublanc; H Schaefer; Josemir W. Sander; Philip N Patsalos
Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy.
Epilepsia 2003;44(1):46-53.
2003: John Williams; Meir Bialer; Svein I Johannessen; Günther Krämer; René Levy; Richard H Mattson; Emilio Perucca; Philip N Patsalos; John F Wilson
Interlaboratory variability in the quantification of new generation antiepileptic drugs based on external quality assessment data.
Epilepsia 2003;44(1):40-5.
2002: Matthias Koepp; Philip N Patsalos; Josemir W. Sander
Sulthiame in adults with refractory epilepsy and learning disability: an open trial.
Epilepsy research 2002;50(3):277-82.
2002: Philip N Patsalos; Walter Fröscher; Francesco Pisani; Clementina van Rijn
The importance of drug interactions in epilepsy therapy.
Epilepsia 2002;43(4):365-85.
2002: HC Doheny; Miles A Whittington; John Jefferys; Philip N Patsalos
A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy.
British journal of pharmacology 2002;135(6):1425-34.
2002: Sanjay M Sisodiya; Josemir W. Sander; Philip N Patsalos
Carbamazepine toxicity during combination therapy with levetiracetam: a pharmacodynamic interaction.
Epilepsy research 2002;48(3):217-9.
2002: Hannah R Cock; Xin Tong; Iain P Hargreaves; Simon J R Heales; John B Clark; Philip N Patsalos; Maria Thom; Michael Groves; Anthony H V Schapira; Simon D Shorvon; Matthew C Walker
Mitochondrial dysfunction associated with neuronal death following status epilepticus in rat.
Epilepsy research 2002;48(3):157-68.
2002: Joanna zakrzewska; Philip N Patsalos
Long-term cohort study comparing medical (oxcarbazepine) and surgical management of intractable trigeminal neuralgia.
Pain 2002;95(3):259-66.
2001: Graeme J Sills; Philip N Patsalos; Elaine Butler; Gerard Forrest; Neville Ratnaraj; Martin J Brodie
Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.
Neurology 2001;57(2):196-200.
2001: John Williams; Philip N Patsalos; Z Mei; G Schapel; John F Wilson; Alan Richens
Relation between dosage of carbamazepine and concentration in hair and plasma samples from a compliant inpatient epileptic population.
Therapeutic drug monitoring 2001;23(1):15-20.
2000: Charles L P Deckers; S J Czuczwar; Yechiel A Hekster; Antoine Keyser; H Kubova; Harry Meinardi; Philip N Patsalos; Willy O Renier; Clementina van Rijn
Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed.
Epilepsia 2000;41(11):1364-74.
2000: M C Walker; X Tong; H Perry; M S Alavijeh; Philip N Patsalos
Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigine.
British journal of pharmacology 2000;130(2):242-8.
2000: Philip N Patsalos
Pharmacokinetic profile of levetiracetam: toward ideal characteristics.
Pharmacology & therapeutics 2000;85(2):77-85.
2000: Philip N Patsalos
Antiepileptic drug pharmacogenetics.
Therapeutic drug monitoring 2000;22(1):127-30.
1999: S Nagaki; Neville Ratnaraj; Philip N Patsalos
Blood and cerebrospinal fluid pharmacokinetics of primidone and its primary pharmacologically active metabolites, phenobarbital and phenylethylmalonamide in the rat.
European journal of drug metabolism and pharmacokinetics 1999;24(3):255-64.
1999: HC Doheny; Neville Ratnaraj; Miles A Whittington; John Jefferys; Philip N Patsalos
Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat.
Epilepsy research 1999;34(2-3):161-8.
1999: M C Walker; H Perry; F Scaravilli; Philip N Patsalos; Simon D Shorvon; John Jefferys
Halothane as a neuroprotectant during constant stimulation of the perforant path.
Epilepsia 1999;40(3):359-64.
1999: Philip N Patsalos
New antiepileptic drugs.
Annals of clinical biochemistry 1999;36 ( Pt 1)():10-9.
1998: Neville Ratnaraj; Philip N Patsalos
A high-performance liquid chromatography micromethod for the simultaneous determination of vigabatrin and gabapentin in serum.
Therapeutic drug monitoring 1998;20(4):430-4.
1998: Matthew C Walker; X Tong; S Brown; Simon D Shorvon; Philip N Patsalos
Comparison of single- and repeated-dose pharmacokinetics of diazepam.
Epilepsia 1998;39(3):283-9.
1997: Graeme J Sills; John Paul Leach; CM Fraser; Gerard Forrest; Philip N Patsalos; Martin J Brodie
Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain.
European journal of pharmacology 1997;325(1):35-40.
1997: John Williams; Philip N Patsalos; John F Wilson
Hair analysis as a potential index of therapeutic compliance in the treatment of epilepsy.
Forensic science international 1997;84(1-3):113-22.
1996: M T O'Connell; F Tison; Niall Quinn; Philip N Patsalos
Clinical drug monitoring by microdialysis: application to levodopa therapy in Parkinson's disease.
British journal of clinical pharmacology 1996;42(6):765-9.
1996: M H Doheny; S Nagaki; Philip N Patsalos
A microdialysis study of glycinamide, glycine and other amino acid neurotransmitters in rat frontal cortex and hippocampus after the administration of milacemide, a glycine pro-drug.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(2):157-63.
1996: M H Doheny; M T O'Connell; Philip N Patsalos
A high-performance liquid-chromatographic microanalytical procedure for the rapid estimation of piracetam in plasma or cerebrospinal fluid.
The Journal of pharmacy and pharmacology 1996;48(5):514-6.
1996: M C Walker; M S Alavijeh; S D Shorvon; Philip N Patsalos
Microdialysis study of the neuropharmacokinetics of phenytoin in rat hippocampus and frontal cortex.
Epilepsia 1996;37(5):421-7.
1996: Neville Ratnaraj; H C Doheny; Philip N Patsalos
A micromethod for the determination of the new antiepileptic drug levetiracetam (ucb LO59) in serum or plasma by high performance liquid chromatography.
Therapeutic drug monitoring 1996;18(2):154-7.
1995: M T O'Connell; Neville Ratnaraj; A A Elyas; M H Doheny; S Darsot; Philip N Patsalos
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
Therapeutic drug monitoring 1995;17(5):549-55.
1995: Gregor Wenning; M T O'Connell; Philip N Patsalos; Niall Quinn
A clinical and pharmacokinetic case study of an interaction of levodopa and antituberculous therapy in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 1995;10(5):664-7.
1995: D L Taylor; S E Davies; Tihomir P Obrenovitch; M H Doheny; Philip N Patsalos; John B Clark; L Symon
Investigation into the role of N-acetylaspartate in cerebral osmoregulation.
Journal of neurochemistry 1995;65(1):275-81.
1995: Philip N Patsalos; W T Abed; M S Alavijeh; M T O'Connell
The use of microdialysis for the study of drug kinetics: some methodological considerations illustrated with antipyrine in rat frontal cortex.
British journal of pharmacology 1995;115(3):503-9.
1994: Y I Lolin; Neville Ratnaraj; M Hjelm; Philip N Patsalos
Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: phenytoin.
Epilepsy research 1994;19(2):99-110.
1994: Philip N Patsalos; Josemir W. Sander
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Drug safety : an international journal of medical toxicology and drug experience 1994;11(1):37-67.
1994: S Sveinbjornsdottir; Josemir W. Sander; Philip N Patsalos; D Upton; P J Thompson; John S Duncan
Neuropsychological effects of tiagabine, a potential new antiepileptic drug.
Seizure : the journal of the British Epilepsy Association 1994;3(1):29-35.
1994: W T Abed; M S Alavijeh; R Bayston; S D Shorvon; Philip N Patsalos
An evaluation of the epileptogenic properties of a rifampicin/clindamycin-impregnated shunt catheter.
British journal of neurosurgery 1994;8(6):725-30.
1993: S Sveinbjornsdottir; Josemir W. Sander; D Upton; P J Thompson; Philip N Patsalos; D Hirt; M Emre; D Lowe; John S Duncan
The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy.
Epilepsy research 1993;16(2):165-74.
1993: Philip N Patsalos; J S Duncan
Antiepileptic drugs. A review of clinically significant drug interactions.
Drug safety : an international journal of medical toxicology and drug experience 1993;9(3):156-84.
1993: J Semba; G Curzon; Philip N Patsalos
Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: milacemide.
British journal of pharmacology 1993;108(4):1117-24.
1993: J Semba; Philip N Patsalos
Milacemide effects on the temporal inter-relationship of amino acids and monoamine metabolites in rat cerebrospinal fluid.
European journal of pharmacology 1993;230(3):321-6.
1992: Josemir W. Sander; Philip N Patsalos
An assessment of serum and red blood cell folate concentrations in patients with epilepsy on lamotrigine therapy.
Epilepsy research 1992;13(1):89-92.
1992: Philip N Patsalos; M S Alavijeh; J Semba; Y I Lolin
A freely moving and behaving rat model for the chronic and simultaneous study of drug pharmacokinetics (blood) and neuropharmacokinetics (cerebrospinal fluid): hematological and biochemical characterization and kinetic evaluation using carbamazepine.
Journal of pharmacological and toxicological methods 1992;28(1):21-8.
1992: T Warner; Philip N Patsalos; M Prevett; A A Elyas; John S Duncan
Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11-epoxide.
Epilepsy research 1992;11(2):147-50.
1992: J Semba; M Doheny; Philip N Patsalos; G Sarna; G Curzon
Effect of milacemide on extracellular and tissue concentrations of dopamine and 5-hydroxytryptamine in rat frontal cortex.
British journal of pharmacology 1992;105(1):59-62.
1991: D M Bell; G Richards; S Dhillon; J R Oxley; J Cromarty; Josemir W. Sander; Philip N Patsalos
A comparative pharmacokinetic study of intravenous and intramuscular midazolam in patients with epilepsy.
Epilepsy research 1991;10(2-3):183-90.
1991: J Semba; Neville Ratnaraj; Philip N Patsalos
Simple and rapid micro-analytical procedures for the estimation of milacemide and its metabolite glycinamide in rat plasma and cerebrospinal fluid by high-performance liquid chromatography.
Journal of chromatography 1991;565(1-2):357-62.
1991: John S Duncan; Philip N Patsalos; S D Shorvon
Effects of discontinuation of phenytoin, carbamazepine, and valproate on concomitant antiepileptic medication.
Epilepsia 1991;32(1):101-15.
1990: Josemir W. Sander; P C Trevisol-Bittencourt; Y M Hart; Philip N Patsalos; S D Shorvon
The efficacy and long-term tolerability of lamotrigine in the treatment of severe epilepsy.
Epilepsy research 1990;7(3):226-9.
1990: Josemir W. Sander; Philip N Patsalos; J R Oxley; M J Hamilton; W C Yuen
A randomised double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy.
Epilepsy research 1990;6(3):221-6.
1990: A A Elyas; V D Goldberg; Philip N Patsalos
Simple and rapid micro-analytical high-performance liquid chromatographic technique for the assay of oxcarbazepine and its primary active metabolite 10-hydroxycarbazepine.
Journal of chromatography 1990;528(2):473-9.
1990: Philip N Patsalos
A comparative pharmacokinetic study of conventional and chewable carbamazepine in epileptic patients.
British journal of clinical pharmacology 1990;29(5):574-7.
1990: Philip N Patsalos; D Russell-Jones; G Finnerty; Josemir W. Sander; S D Shorvon
The efficacy and tolerability of chewable carbamazepine compared to conventional carbamazepine in patients with epilepsy.
Epilepsy research 1990;5(3):235-9.
1990: Philip N Patsalos; J M Zakrzewska; A A Elyas
Dose dependent enzyme induction by oxcarbazepine?
European journal of clinical pharmacology 1990;39(2):187-8.
1990: Philip N Patsalos; A A Elyas; J M Zakrzewska
Protein binding of oxcarbazepine and its primary active metabolite, 10-hydroxycarbazepine, in patients with trigeminal neuralgia.
European journal of clinical pharmacology 1990;39(4):413-5.
1990: R Nijhawan; A S Wierzbicki; R Tozer; P T Lascelles; Philip N Patsalos
Antiepileptic drugs, hepatic enzyme induction and raised serum alkaline phosphatase isoenzymes.
International journal of clinical pharmacology research 1990;10(6):319-23.
1988: Philip N Patsalos; J S Duncan; S D Shorvon
Effect of the removal of individual antiepileptic drugs on antipyrine kinetics, in patients taking polytherapy.
British journal of clinical pharmacology 1988;26(3):253-9.
1988: Josemir W. Sander; Philip N Patsalos
Allopurinol as an add-on drug in the management of intractable epilepsy.
Epilepsy research 1988;2(3):223-5.
1988: E N Sokomba; Philip N Patsalos; Y I Lolin; G Curzon
Concurrent monitoring of central carbamazepine and transmitter amine metabolism and motor activity in individual unrestrained rats using repetitive withdrawal of cerebrospinal fluid.
Neuropharmacology 1988;27(4):409-15.
1988: Philip N Patsalos; M S Alavijeh; W Brownhill; P T Lascelles
Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(1):111-4.
1987: Philip N Patsalos; S Krishna; A A Elyas; P T Lascelles
Carbamazepine and carbamazepine-10,11-epoxide pharmacokinetics in an overdose patient.
Human toxicology 1987;6(3):241-4.
1986: O A Agbato; A A Elyas; Philip N Patsalos; E M Brett; P T Lascelles
Total and free serum concentrations of carbamazepine and carbamazepine-10,11-epoxide in children with epilepsy.
Archives of neurology 1986;43(11):1111-6.
1986: A A Elyas; Philip N Patsalos; O A Agbato; E M Brett; P T Lascelles
Factors influencing simultaneous concentrations of total and free carbamazepine and carbamazepine-10, 11-epoxide in serum of children with epilepsy.
Therapeutic drug monitoring 1986;8(3):288-92.
1985: Philip N Patsalos; T J Stephenson; S Krishna; A A Elyas; P T Lascelles; C M Wiles
Side-effects induced by carbamazepine-10,11-epoxide.
Lancet 1985;2(8469-70):1432.
1985: Philip N Patsalos; T J Stephenson; S Krishna; A A Elyas; P T Lascelles; C M Wiles
Side-effects induced by carbamazepine-10,11-epoxide.
Lancet 1985;2(8453):496.
1985: Philip N Patsalos; S D Shorvon; A A Elyas; G Smith
The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin.
Journal of neurology, neurosurgery, and psychiatry 1985;48(4):374-7.
1984: Philip N Patsalos; P T Lascelles
Metabolic interactions of phenytoin in the rat: effect of coadministration with the anticonvulsant drugs sodium valproate, sulthiame, ethosuximide or phenobarbital.
General pharmacology 1984;15(1):7-12.
1982: Philip N Patsalos; P T Lascelles
Effect of sodium valproate and ethosuximide on phenobarbital plasma protein binding.
Neurology 1982;32(9):1052-3.
1981: Philip N Patsalos; P T Lascelles
Changes in regional brain levels of amino acid putative neurotransmitters after prolonged treatment with the anticonvulsant drugs diphenylhydantoin, phenobarbitone, sodium valproate, ethosuximide, and sulthiame in the rat.
Journal of neurochemistry 1981;36(2):688-95.
1981: Philip N Patsalos; P T Lascelles
Inhibition of in vitro diphenylhydantoin hydroxylation by different anticonvulsant drug combinations: a kinetic analysis.
General pharmacology 1981;12(1):51-5.
1980: Philip N Patsalos; P T Lascelles
Diphenylhydantoin substrate induced difference spectra: inhibition by other anticonvulsant drugs.
Research communications in chemical pathology and pharmacology 1980;27(1):31-43.