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Tanya Paull

Research Profile

Chemicals & Drugs

Physiology

Disorders

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Saccharomyces cerevisiae

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Publications

TOP 3
Ji-Hoon Lee; Michael R Mand; Rajashree A Deshpande; Eri Kinoshita; Claire Wyman; Soo-Hyun Yang; Tanya T Paull
Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex.
Soo-Hyun Yang; Ruobo Zhou; Judith Campbell; Junjie Chen; Taekjip Ha; Tanya T Paull
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.
Jeremy A Daniel; Lionel Feigenbaum; Darius Filsuf; Zhi Guo; Baeck-Seung Lee; Tanya T Paull; Manuela Pellegrini; Barry P Sleckman; Zhongsheng You; Natalya V Belkina; André Nussenzweig
Loss of ATM kinase activity leads to embryonic lethality in mice.

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All Publications

2013: Ji-Hoon Lee; Michael R Mand; Rajashree A Deshpande; Eri Kinoshita; Claire Wyman; Soo-Hyun Yang; Tanya T Paull
Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex.
The Journal of biological chemistry 2013;288(18):12840-51.
2013: Soo-Hyun Yang; Ruobo Zhou; Judith Campbell; Junjie Chen; Taekjip Ha; Tanya T Paull
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.
The EMBO journal 2013;32(1):126-39.
2012: Jeremy A Daniel; Lionel Feigenbaum; Darius Filsuf; Zhi Guo; Baeck-Seung Lee; Tanya T Paull; Manuela Pellegrini; Barry P Sleckman; Zhongsheng You; Natalya V Belkina; André Nussenzweig
Loss of ATM kinase activity leads to embryonic lethality in mice.
The Journal of cell biology 2012;198(3):295-304.
2012: Scott Ditch; Tanya T Paull
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response.
Trends in biochemical sciences 2012;37(1):15-22.
2011: Julie Della-Maria; Jeff Kuhnlein; Tanya T Paull; Miaw-Sheue Tsai; Yi Zhou; James P Carney; Alan E Tomkinson
Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
The Journal of biological chemistry 2011;286(39):33845-53.
2011: Magtouf Gatei; Nuri Gueven; Burkhard Jakob; Reinhard Kalb; Amanda W Kijas; Olivier J Becherel; Geoff Birrell; Philip Chen; Thilo Dörk; Shazrul Fazry; Ji-Hoon Lee; Yaniv lerenthal; Tanya T Paull; Detlev Schindler; Gisela Taucher-Scholz; Regina Waltes; Martin F Lavin
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
The Journal of biological chemistry 2011;286(36):31542-56.
2010: Zhi Guo; Rajashree Deshpande; Tanya T Paull
ATM activation in the presence of oxidative stress.
Cell cycle (Georgetown, Tex.) 2010;9(24):4805-11.
2010: Tanya T Paull
Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.
DNA repair 2010;9(12):1283-91.
2010: Matthew L Nicolette; Kihoon Lee; Zhi Guo; Mridula Rani; Julia M Chow; Sang Lee; Tanya T Paull
Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks.
Nature structural & molecular biology 2010;17(12):1478-85.
2010: Zhi Guo; Sergei Kozlov; Martin F Lavin; Maria D Person; Tanya T Paull
ATM activation by oxidative stress.
Science (New York, N.Y.) 2010;330(6003):517-21.
2010: Eun Yong Shim; Woo-Hyun Chung; Matthew L Nicolette; Yu Zhang; Melody Davis; Zhu Zhu; Tanya T Paull; Grzegorz Ira; Sang Lee
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks.
The EMBO journal 2010;29(19):3370-80.
2010: Ann Demogines; Alysia M East; Ji-Hoon Lee; Sharon R Grossman; Pardis C Sabeti; Tanya T Paull; Sara L Sawyer
Ancient and recent adaptive evolution of primate non-homologous end joining genes.
PLoS genetics 2010;6(10):e1001169.
2010: Ji-Hoon Lee; Aaron A Goodarzi; Penny A Jeggo; Tanya T Paull
53BP1 promotes ATM activity through direct interactions with the MRN complex.
The EMBO journal 2010;29(3):574-85.
2008: Jeremy A Daniel; Manuela Pellegrini; Ji-Hoon Lee; Tanya T Paull; Lionel Feigenbaum; André Nussenzweig
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
The Journal of cell biology 2008;183(5):777-83.
2008: Ben B Hopkins; Tanya T Paull
The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break.
Cell 2008;135(2):250-60.
2008: Derek Richard; Emma Bolderson; Liza Cubeddu; Ross I M Wadsworth; Kienan Savage; Girdhar G Sharma; Matthew L Nicolette; Sergie Tsvetanov; Michael J McIlwraith; Raj K Pandita; Shunichi Takeda; Ron Thomas Hay; Jean Gautier; Stephen C West; Tanya T Paull; Tej K Pandita; Malcolm White; Kum Kum Khanna
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
Nature 2008;453(7195):677-81.
2008: Aude Dupré; Louise Boyer-Chatenet; Rose M Sattler; Ami P Modi; Ji-Hoon Lee; Matthew L Nicolette; Levy Kopelovich; Maria Jasin; Richard Baer; Tanya T Paull; Jean Gautier
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
Nature chemical biology 2008;4(2):119-25.
2007: J-H Lee; Tanya T Paull
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.
Oncogene 2007;26(56):7741-8.
2007: Bettina Lengsfeld; Alison J Rattray; Venugopal Bhaskara; Rodolfo Ghirlando; Tanya T Paull
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.
Molecular cell 2007;28(4):638-51.
2007: Shunichi Takeda; Kyoko Nakamura; Yoshihito Taniguchi; Tanya T Paull
Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination.
Molecular cell 2007;28(3):351-2.
2007: Clayton R Hunt; Raj K Pandita; Andrei Laszlo; Ryuji Higashikubo; Manjula Agarwal; Tetsuya Kitamura; Arun Gupta; Nicole Rief; Nobuo Horikoshi; Rajeskaran Baskaran; Ji-Hoon Lee; Markus Löbrich; Tanya T Paull; Joseph L Roti Roti; Tej K Pandita
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
Cancer research 2007;67(7):3010-7.
2007: Venugopal Bhaskara; Aude Dupré; Bettina Lengsfeld; Ben B Hopkins; Angela Chan; Ji-Hoon Lee; Xiaoming Zhang; Jean Gautier; Virginia Zakian; Tanya T Paull
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
Molecular cell 2007;25(5):647-61.
2006: André Nussenzweig; Tanya T Paull
DNA repair: tails of histones lost.
Nature 2006;439(7075):406-7.
2006: Zhenkun Lou; Katherine Minter-Dykhouse; Sonia Franco; Monica Gostissa; Melissa A Rivera; Arkady Celeste; John P Manis; Jan M A van Deursen; André Nussenzweig; Tanya T Paull; Frederick W Alt; Junjie Chen
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
Molecular cell 2006;21(2):187-200.
2006: Ji-Hoon Lee; Tanya T Paull
Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1.
Methods in enzymology 2006;408():529-39.
2006: Wen-Hsing Cheng; Rika Kusumoto; Patricia L Opresko; XiuFen Sui; Shurong Huang; Matthew L Nicolette; Tanya T Paull; Judith Campisi; Michael M Seidman; Vilhelm A Bohr
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.
Nucleic acids research 2006;34(9):2751-60.
2005: Xiaoming Zhang; Tanya T Paull
The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae.
DNA repair 2005;4(11):1281-94.
2005: Tanya T Paull
Saving the ends for last: the role of pol mu in DNA end joining.
Molecular cell 2005;19(3):294-6.
2005: Arun Gupta; Girdhar G Sharma; C S H Young; Manjula Agarwal; Edwin R Smith; Tanya T Paull; John C Lucchesi; Kum Kum Khanna; Thomas Ludwig; Tej K Pandita
Involvement of human MOF in ATM function.
Molecular and cellular biology 2005;25(12):5292-305.
2005: Tanya T Paull; Ji-Hoon Lee
The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.
Cell cycle (Georgetown, Tex.) 2005;4(6):737-40.
2005: Ji-Hoon Lee; Tanya T Paull
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
Science (New York, N.Y.) 2005;308(5721):551-4.
2004: Vincenzo Costanzo; Tanya T Paull; Max Gottesman; Jean Gautier
Mre11 assembles linear DNA fragments into DNA damage signaling complexes.
PLoS biology 2004;2(5):E110.
2004: Ji-Hoon Lee; Tanya T Paull
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
Science (New York, N.Y.) 2004;304(5667):93-6.
2004: Gabriel Moncalian; Bettina Lengsfeld; Venugopal Bhaskara; Karl-Peter Hopfner; Annette Karcher; Erinn Alden; John A Tainer; Tanya T Paull
The rad50 signature motif: essential to ATP binding and biological function.
Journal of molecular biology 2004;335(4):937-51.
2003: Ji-Hoon Lee; Rodolfo Ghirlando; Venugopal Bhaskara; Michaela Hoffmeyer; Jian Gu; Tanya T Paull
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.
The Journal of biological chemistry 2003;278(46):45171-81.
2001: Tanya T Paull
New glimpses of an old machine.
Cell 2001;107(5):563-5.
2001: Tanya T Paull; D Cortez; B Bowers; S J Elledge; Martin Gellert
Direct DNA binding by Brca1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6086-91.
2000: Tanya T Paull; Emmy P Rogakou; Vikky Yamazaki; Cordula U Kirchgessner; Martin Gellert; William M Bonner
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Current biology : CB 2000;10(15):886-95.
2000: Tanya T Paull; Martin Gellert
A mechanistic basis for Mre11-directed DNA joining at microhomologies.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6409-14.
1999: Tanya T Paull; Martin Gellert
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex.
Genes & development 1999;13(10):1276-88.
1999: Martin Gellert; Joanne E Hesse; K Hiom; Meni Melek; Mauro Modesti; Tanya T Paull; Dale A Ramsden; Dik C van Gent
V(D)J recombination: links to transposition and double-strand break repair.
Cold Spring Harbor symposia on quantitative biology 1999;64():161-7.
1998: Tanya T Paull; Martin Gellert
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
Molecular cell 1998;1(7):969-79.
1997: Dale A Ramsden; Tanya T Paull; Martin Gellert
Cell-free V(D)J recombination.
Nature 1997;388(6641):488-91.
1997: Dik C van Gent; K Hiom; Tanya T Paull; Martin Gellert
Stimulation of V(D)J cleavage by high mobility group proteins.
The EMBO journal 1997;16(10):2665-70.
1996: Tanya T Paull; Michael Carey; Reid C Johnson
Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro.
Genes & development 1996;10(21):2769-81.
1995: Tanya T Paull; Reid C Johnson
DNA looping by Saccharomyces cerevisiae high mobility group proteins NHP6A/B. Consequences for nucleoprotein complex assembly and chromatin condensation.
The Journal of biological chemistry 1995;270(15):8744-54.
1994: Tanya T Paull; M J Haykinson; Reid C Johnson
HU and functional analogs in eukaryotes promote Hin invertasome assembly.
Biochimie 1994;76(10-11):992-1004.
1993: Tanya T Paull; M J Haykinson; Reid C Johnson
The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.
Genes & development 1993;7(8):1521-34.
1992: H M Mahbubani; Tanya T Paull; J K Elder; Jackson Blow
DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts.
Nucleic acids research 1992;20(7):1457-62.
1988: J E Fleming; Tanya T Paull
Semi-dry electroblotting of DNA.
BioTechniques 1988;6(10):926, 928-9.