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Hans Paulsen

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TOP 3
Inka Brockhausen; Thomas Dowler; Hans Paulsen
Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2.
Inka Brockhausen; Melinda Benn; Shridhar Bhat; Sandra Marone; John G Riley; Pedro J Montoya-Peleaz; Jason Z Vlahakis; Hans Paulsen; John S Schutzbach; Walter A Szarek
UDP-Gal: GlcNAc-R beta1,4-galactosyltransferase--a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme.
Uwe Karsten; Nida Serttas; Hans Paulsen; Antje Danielczyk; Steffen Goletz
Binding patterns of DTR-specific antibodies reveal a glycosylation-conditioned tumor-specific epitope of the epithelial mucin (MUC1).

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All Publications

2009: Inka Brockhausen; Thomas Dowler; Hans Paulsen
Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2.
Biochimica et biophysica acta 2009;1790(10):1244-57.
2006: Inka Brockhausen; Melinda Benn; Shridhar Bhat; Sandra Marone; John G Riley; Pedro J Montoya-Peleaz; Jason Z Vlahakis; Hans Paulsen; John S Schutzbach; Walter A Szarek
UDP-Gal: GlcNAc-R beta1,4-galactosyltransferase--a target enzyme for drug design. Acceptor specificity and inhibition of the enzyme.
Glycoconjugate journal 2006;23(7-8):525-41.
2004: Uwe Karsten; Nida Serttas; Hans Paulsen; Antje Danielczyk; Steffen Goletz
Binding patterns of DTR-specific antibodies reveal a glycosylation-conditioned tumor-specific epitope of the epithelial mucin (MUC1).
Glycobiology 2004;14(8):681-92.
2002: Heiko Möller; Nida Serttas; Hans Paulsen; Joy M Burchell; Joyce Taylor-Papadimitriou
NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3.
European journal of biochemistry / FEBS 2002;269(5):1444-55.
2002: Inka Brockhausen; Michael Lehotay; Ji-Mao Yang; Wensheng Qin; David Young; Jamie Lucien; John Coles; Hans Paulsen
Glycoprotein biosynthesis in porcine aortic endothelial cells and changes in the apoptotic cell population.
Glycobiology 2002;12(1):33-45.
2001: Hans Paulsen; Inka Brockhausen
From imino sugars to cancer glycoproteins.
Glycoconjugate journal 2001;18(11-12):867-70.
1999: O Schuster; G Klich; V Sinnwell; H Kränz; Hans Paulsen; B Meyer
'Wave-type' structure of a synthetic hexaglycosylated decapeptide: a part of the extracellular domain of human glycophorin A.
Journal of biomolecular NMR 1999;14(1):33-45.
1998: A Schäfer; G Klich; M Schreiber; Hans Paulsen; Joachim Thiem
Synthesis of an N-glucoasparagine analog as a building block for a V3-loop glycopeptide from gp120 of HIV-I.
Carbohydrate research 1998;313(2):107-16.
1998: Uwe Karsten; C Diotel; G Klich; Hans Paulsen; Steffen Goletz; S Müller; Franz-Georg Hanisch
Enhanced binding of antibodies to the DTR motif of MUC1 tandem repeat peptide is mediated by site-specific glycosylation.
Cancer research 1998;58(12):2541-9.
1997: G Klich; Hans Paulsen; B Meyer; M Meldal; K Bock
Synthesis and characterisation of highly glycosylated glycopeptides with Tn-antigenic structures corresponding to human glycophorin AN.
Carbohydrate research 1997;299(1-2):33-48.
1996: Inka Brockhausen; D Toki; J Brockhausen; S Peters; T Bielfeldt; A Kleen; Hans Paulsen; Morten Meldal; F Hagen; Lawrence Tabak
Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates.
Glycoconjugate journal 1996;13(5):849-56.
1995: F Reck; M Springer; E Meinjohanns; Hans Paulsen; Inka Brockhausen; Harry Schachter
Synthetic substrate analogues for UDP-GlcNAc: Man alpha 1-3R beta 1-2-N-acetylglucosaminyltransferase I. Substrate specificity and inhibitors for the enzyme.
Glycoconjugate journal 1995;12(6):747-54.
1995: Hans Paulsen; M Springer; F Reck; Inka Brockhausen; Harry Schachter
[Synthesis of modified tetrasaccharides as analog acceptor-inhibitors of N-acetylglucosaminyltransferase II].
Carbohydrate research 1995;275(2):403-11.
1995: F Reck; E Meinjohanns; Jenny Tan; A A Grey; Hans Paulsen; Harry Schachter
Synthesis of pentasaccharide analogues of the N-glycan substrates of N-acetylglucosaminyltransferases III, IV and V using tetrasaccharide precursors and recombinant beta-(1-->2)-N-acetylglucosaminyltransferase II.
Carbohydrate research 1995;275(2):221-9.
1995: W Kuhns; R K Jain; K L Matta; Hans Paulsen; M A Baker; R Geyer; Inka Brockhausen
Characterization of a novel mucin sulphotransferase activity synthesizing sulphated O-glycan core 1,3-sulphate-Gal beta 1-3GalNAc alpha-R.
Glycobiology 1995;5(7):689-97.
1995: Inka Brockhausen; F Reck; W Kuhns; S Khan; K L Matta; E Meinjohanns; Hans Paulsen; R N Shah; M A Baker; Harry Schachter
Substrate specificity and inhibition of UDP-GlcNAc:GlcNAc beta 1-2Man alpha 1-6R beta 1,6-N-acetylglucosaminyltransferase V using synthetic substrate analogues.
Glycoconjugate journal 1995;12(3):371-9.
1995: F Vavasseur; J M Yang; K Dole; Hans Paulsen; Inka Brockhausen
Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines.
Glycobiology 1995;5(3):351-7.
1995: Hans Paulsen; S Peters; T Bielfeldt; Morten Meldal; K Bock
Synthesis of the glycosyl amino acids N alpha-Fmoc-Ser[Ac4-beta-D-Galp-(1-->3)-Ac2-alpha-D-GalN3p]-OPfp and N alpha-Fmoc-Thr[Ac4-beta-D-Galp-(1-->3)-Ac2-alpha-D-GalN3p]-OPfp and the application in the solid-phase peptide synthesis of multiply glycosylated mucin peptides with Tn and T antigenic structures.
Carbohydrate research 1995;268(1):17-34.
1994: F Reck; M Springer; Hans Paulsen; Inka Brockhausen; Mohan Sarkar; Harry Schachter
Synthesis of tetrasaccharide analogues of the N-glycan substrate of beta-(1-->2)-N-acetylglucosaminyltransferase II using trisaccharide precursors and recombinant beta-(1-->2)-N-acetylglucosaminyltransferase I.
Carbohydrate research 1994;259(1):93-101.
1994: Morten Meldal; T Bielfeldt; S Peters; K J Jensen; Hans Paulsen; K Bock
Susceptibility of glycans to beta-elimination in Fmoc-based O-glycopeptide synthesis.
International journal of peptide and protein research 1994;43(6):529-36.
1994: F Reck; E Meinjohanns; M Springer; R Wilkens; J A Van Dorst; Hans Paulsen; G Möller; Inka Brockhausen; Harry Schachter
Synthetic substrate analogues for UDP-GlcNAc: Man alpha 1-6R beta(1-2)-N-acetylglucosaminyltransferase II. Substrate specificity and inhibitors for the enzyme.
Glycoconjugate journal 1994;11(3):210-6.
1994: M Granovsky; T Bielfeldt; S Peters; Hans Paulsen; Morten Meldal; J Brockhausen; Inka Brockhausen
UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity synthesizing O-glycan core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates.
European journal of biochemistry / FEBS 1994;221(3):1039-46.
1993: W Kuhns; V Rutz; Hans Paulsen; K L Matta; M A Baker; M Barner; M Granovsky; Inka Brockhausen
Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc: Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferase.
Glycoconjugate journal 1993;10(5):381-94.
1992: Hans Paulsen; F Reck; Inka Brockhausen
[Synthesis of modified oligosaccharides of the N-glycoprotein as substrate for N-acetylglucosaminyltransferase I].
Carbohydrate research 1992;236():39-71.
1992: Inka Brockhausen; G Möller; J M Yang; S H Khan; K L Matta; Hans Paulsen; A A Grey; R N Shah; Harry Schachter
Control of glycoprotein synthesis. Characterization of (1-->4)-N-acetyl-beta-D-glucosaminyltransferases acting on the alpha-D-(1-->3)- and alpha-D-(1-->6)-linked arms of N-linked oligosaccharides.
Carbohydrate research 1992;236():281-99.
1992: G Möller; F Reck; Hans Paulsen; kanwal jeet kaur; Mohan Sarkar; Harry Schachter; Inka Brockhausen
Control of glycoprotein synthesis: substrate specificity of rat liver UDP-GlcNAc:Man alpha 3R beta 2-N-acetylglucosaminyltransferase I using synthetic substrate analogues.
Glycoconjugate journal 1992;9(4):180-90.
1992: Joachim Thiem; P Stangier; P Matschulat; Hans Paulsen
Synthesis of a glycosidic affinity ligand for purification of cytidine-5'-monophosphosialate synthase.
Carbohydrate research 1992;225(1):147-50.
1992: Inka Brockhausen; G Möller; A Pollex-Krüger; V Rutz; Hans Paulsen; K L Matta
Control of O-glycan synthesis: specificity and inhibition of O-glycan core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 3-galactosyltransferase from rat liver.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(2):99-108.
1991: Hans Paulsen; B Helpap
[Synthesis of partial structure of complex types of N-glycoproteins].
Carbohydrate research 1991;216():289-313.
1991: Hans Paulsen; R Busch; V Sinnwell; A Pollex-Krüger
[Conformation analysis of D-xylose-containing O-glycopeptide sequences].
Carbohydrate research 1991;214(2):227-34.
1991: Hans Paulsen; A Pollex-Krüger; V Sinnwell
[Conformational analysis of N-terminal O-glycopeptide sequences of interleukin-2].
Carbohydrate research 1991;214(2):199-226.
1990: Inka Brockhausen; G Möller; G Merz; K Adermann; Hans Paulsen
Control of mucin synthesis: the peptide portion of synthetic O-glycopeptide substrates influences the activity of O-glycan core 1 UDPgalactose:N-acetyl-alpha-galactosaminyl-R beta 3-galactosyltransferase.
Biochemistry 1990;29(44):10206-12.
1990: Hans Paulsen; C Krogmann
[Synthesis of a Kdo-containing pentasaccharide sequence of the inner core- and lipid A-region of lipopolysaccharides].
Carbohydrate research 1990;205():31-44.
1990: Hans Paulsen; M Heume; H Nürnberger
[Synthesis of a highly branched nonasaccharide sequence of the "bisected"structure of N-glycoproteins].
Carbohydrate research 1990;200():127-66.
1989: Hans Paulsen; B Helpap
[Synthesis of a tetrasaccharide unit of the capsular polysaccharide of Streptococcus pneumoniae type 9V].
Carbohydrate research 1989;186(2):189-205.
1988: Hans Paulsen; B Helpap; J P Lorentzen
[Synthesis of trisaccharide units from capsular polysaccharides of Streptococcus pneumoniae].
Carbohydrate research 1988;179():173-97.
1988: Y Nishikawa; W Pegg; Hans Paulsen; Harry Schachter
Control of glycoprotein synthesis. Purification and characterization of rabbit liver UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.
The Journal of biological chemistry 1988;263(17):8270-81.
1988: Hans Paulsen; U von Deessen
[Synthesis of O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2- nonulo-pyranosyluronic)-(2----3)-O-beta-D-galactopyrano sylp61 ----3)-2-acetamido-2-deoxy-D-galactopyranose].
Carbohydrate research 1988;175(2):283-93.
1987: Hans Paulsen; Thomas Peters; V Sinnwell; B Meyer
[Conformation analysis of modified tetrasaccharide sequences of the N-glycoprotein type--problem of the alpha-(1 to 6)-glycosidic bond].
Carbohydrate research 1987;165(2):251-66.
1987: Hans Paulsen; Thomas Peters
[Synthesis of modified tetrasaccharide sequences of N-glycoproteins].
Carbohydrate research 1987;165(2):229-49.
1986: Hans Paulsen; Thomas Peters; V Sinnwell; M Heume; B Meyer
[Conformational analysis of the double pentasaccharide sequence of the "bisected" structure ov N-glycoproteins].
Carbohydrate research 1986;156():87-106.
1985: Hans Paulsen; M Heume; Z Györgydeak; R Lebuhn
[Synthesis of a branched pentasaccharide sequence of "bisected" structure of N-glycoproteins].
Carbohydrate research 1985;144(1):57-70.