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Jan Erik Paulsen

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Camilla Svendsen; Helle K Knutsen; Jan Erik Paulsen; Jan Alexander; Anne Lise Brantsaeter; Hege Hjertholm; Trine Husøy
The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice.
Jo Waaler; Steven Ray Wilson; Huyen Dinh; Tor J Eide; Dietmar Gradl; Vladimir Korinek; Ondrej Machon; Olga Machonova; Jan Erik Paulsen; Nina Marie Pedersen; Lucie Tumova; Jens Peter von Kries; Andrey Edwrd Voronkov; Stefan Krauss
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
T Ø Fotland; Jan Erik Paulsen; Tore Sanner; J Alexander; Trine Husøy
Risk assessment of coumarin using the bench mark dose (BMD) approach: children in Norway which regularly eat oatmeal porridge with cinnamon may exceed the TDI for coumarin with several folds.

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All Publications

2012: Camilla Svendsen; Helle K Knutsen; Jan Erik Paulsen; Jan Alexander; Anne Lise Brantsaeter; Hege Hjertholm; Trine Husøy
The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice.
Laboratory animals 2012;46(3):207-14.
2012: Jo Waaler; Steven Ray Wilson; Huyen Dinh; Tor J Eide; Dietmar Gradl; Vladimir Korinek; Ondrej Machon; Olga Machonova; Jan Erik Paulsen; Nina Marie Pedersen; Lucie Tumova; Jens Peter von Kries; Andrey Edwrd Voronkov; Stefan Krauss
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
Cancer research 2012;72(11):2822-32.
2012: T Ø Fotland; Jan Erik Paulsen; Tore Sanner; J Alexander; Trine Husøy
Risk assessment of coumarin using the bench mark dose (BMD) approach: children in Norway which regularly eat oatmeal porridge with cinnamon may exceed the TDI for coumarin with several folds.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(3-4):903-12.
2011: Kristoffer W Brudvik; Jan Erik Paulsen; Borghild Roald; Einar M Aandahl; Kjetil Taskén
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice.
Molecular cancer 2011;10():149.
2011: Jo Waaler; Ondrej Machon; Jens Peter von Kries; Steven Ray Wilson; Elsa Lundenes; Doris Wedlich; Dietmar Gradl; Jan Erik Paulsen; Olga Machonova; Jennifer Dembinski; Huyen Dinh; Stefan Krauss
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
Cancer research 2011;71(1):197-205.
2009: Ragna Bogen Hetland; Jan Alexander; Jens Berg; Camilla Svendsen; Jan Erik Paulsen
Retinol-induced intestinal tumorigenesis in Min/+ mice and importance of vitamin D status.
Anticancer research 2009;29(11):4353-60.
2009: Camilla Svendsen; Trine Husøy; Hansruedi Glatt; Jan Erik Paulsen; Jan Alexander
5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice.
Anticancer research 2009;29(6):1921-6.
2009: Nur Duale; Thomas Bjellaas; Jan Alexander; Georg Becher; Margaretha Haugen; Jan Erik Paulsen; Henrik Frandsen; Pelle Thonning Olesen; Gunnar Brunborg
Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):90-9.
2008: Bjørn Hofmann; Jan Erik Paulsen; Per Nortvedt
[It's difference between research and copying].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 2008;128(13):1544.
2007: Thomas Bjellaas; Hege B Ølstørn; Georg Becher; Jan Alexander; Svein Halvor Knutsen; Jan Erik Paulsen
Urinary metabolites as biomarkers of acrylamide exposure in mice following dietary crisp bread administration or subcutaneous injection.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(2):374-80.
2007: Hege Benedikte Olstørn; Jan Erik Paulsen; Jan Alexander
Effects of perinatal exposure to acrylamide and glycidamide on intestinal tumorigenesis in Min/+ mice and their wild-type litter mates.
Anticancer research 2007;27(6B):3855-64.
2007: Thomas Bjellaas; Pelle T Olesen; Henrik Frandsen; Margaretha Haugen; Linn H Stølen; Jan Erik Paulsen; Jan Alexander; Elsa Lundanes; Georg Becher
Comparison of estimated dietary intake of acrylamide with hemoglobin adducts of acrylamide and glycidamide.
Toxicological sciences : an official journal of the Society of Toxicology 2007;98(1):110-7.
2007: Thomas Bjellaas; Linn Helene Stølen; Margaretha Haugen; Jan Erik Paulsen; Jan Alexander; Elsa Lundanes; Georg Becher
Urinary acrylamide metabolites as biomarkers for short-term dietary exposure to acrylamide.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(6):1020-6.
2006: Jan Erik Paulsen; Inger-Lise Steffensen; Hege Benedikte Olstørn; Jan Alexander
Prevalent location of flat dysplastic aberrant crypt foci near lymphoid follicles in the colon of azoxymethane-treated rats.
Anticancer research 2006;26(3A):1803-7.
2006: Jan Erik Paulsen; Helle K Knutsen; Hege B Ølstørn; Else Marit Løberg; Jan Alexander
Identification of flat dysplastic aberrant crypt foci in the colon of azoxymethane-treated A/J mice.
International journal of cancer. Journal international du cancer 2006;118(3):540-6.
2005: Jan Erik Paulsen; Ellen Namork; Jan Alexander
Scanning electron microscopy of colonic lesions in 1,2-dimethylhydrazine-treated rats.
Anticancer research 2005;25(6B):3883-8.
2005: Helle K Knutsen; Hege Benedikte Olstørn; Jan Erik Paulsen; Trine Husøy; Ingeborg L Goverud; Else Marit Løberg; Karsten Kristiansen; Jan Alexander
Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice.
Anticancer research 2005;25(6B):3781-9.
2005: Trine Husøy; L Abramsson-Zetterberg; Hege B Ølstørn; Jan Erik Paulsen; Jan Alexander
Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes.
Mutation research 2005;580(1-2):111-8.
2005: Jan Erik Paulsen; Else Marit Løberg; Hege Benedikte Olstørn; Helle K Knutsen; Inger-Lise Steffensen; Jan Alexander
Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat.
Cancer research 2005;65(1):121-9.
2004: Linda Møllersen; Jan Erik Paulsen; Jan Alexander
Loss of heterozygosity and nonsense mutation in Apc in azoxymethane-induced colonic tumours in min mice.
Anticancer research 2004;24(5A):2595-9.
2004: Wenche H Reichelt; Jens-Gustav Iversen; Jan Erik Paulsen; Kjell Elgjo; Karl L Reichelt
Pyroglutamyl-histidyl-glycine, the endogenous colon mitosis inhibitor, regulates cyclic AMP level in non-tumorigenic colonic epithelial cells.
Anticancer research 2004;24(3a):1465-8.
2004: Linda Møllersen; Rose Vikse; Ashild Andreassen; Inger-Lise Steffensen; Arne Mikalsen; Jan Erik Paulsen; Jan Alexander
Adenomatous polyposis coli truncation mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumours of multiple intestinal neoplasia mice.
Mutation research 2004;557(1):29-40.
2004: Linda Møllersen; Jan Erik Paulsen; Hege Benedikte Olstørn; Helle K Knutsen; Jan Alexander
Dietary retinoic acid supplementation stimulates intestinal tumour formation and growth in multiple intestinal neoplasia (Min)/+ mice.
Carcinogenesis 2004;25(1):149-53.
2003: Inger-Lise Steffensen; Karel Janak; Solfrid Hegstad; Ashild Andreassen; Jan Erik Paulsen; Ragnhild Reistad; Jan Alexander
Incorporation of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) into fur and correlation with intestinal tumourigenesis in Min/+ mice.
Pharmacology & toxicology 2003;92(3):131-6.
2003: Jan Erik Paulsen; Inger-Lise Steffensen; Ellen Namork; Tor Jacob Eide; Jan Alexander
Age-dependent susceptibility to azoxymethane-induced and spontaneous tumorigenesis in the Min/+ mouse.
Anticancer research 2003;23(1A):259-65.
2002: Paal H H Lindenskov; Jan Erik Paulsen; Karl L Reichelt; Kjell Elgjo
Endogenous tetrapeptide from neuroblastoma and new-born pig brain inhibits neuroblastoma cell growth in vitro.
Anticancer research 2002;22(5):2847-51.
2002: Inger-Lise Steffensen; Jan Erik Paulsen; Jan Alexander
The food mutagen 2-amino-9H-pyrido[2,3-b]indole (AalphaC) but not its methylated form (MeAalphaC) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice.
Carcinogenesis 2002;23(8):1373-8.
2002: Jan Alexander; Ragnhild Reistad; Solfrid Hegstad; Henrik Frandsen; K Ingebrigtsen; Jan Erik Paulsen; Georg Becher
Biomarkers of exposure to heterocyclic amines: approaches to improve the exposure assessment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(8):1131-7.
2002: Ashild Andreassen; Linda Møllersen; Rose Vikse; Inger-Lise Steffensen; Arne Mikalsen; Jan Erik Paulsen; Jan Alexander
One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene.
Mutation research 2002;517(1-2):157-66.
2002: Jan Erik Paulsen; Jens Bjørheim; Janne Røe; Tor Jacob Eide; Jan Alexander; Gustav Gaudernack
Effect of vaccination with mutant KRAS peptides on rat colon carcinogenesis induced by azoxymethane.
Anticancer research 2002;22(1A):171-5.
2001: Inger-Lise Steffensen; Herman A J Schut; Jan Erik Paulsen; Ashild Andreassen; Jan Alexander
Intestinal tumorigenesis in multiple intestinal neoplasia mice induced by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: perinatal susceptibility, regional variation, and correlation with DNA adducts.
Cancer research 2001;61(24):8689-96.
2001: Jan Erik Paulsen; Jan Alexander
Growth stimulation of intestinal tumours in Apc(Min/+) mice by dietary L-methionine supplementation.
Anticancer research 2001;21(5):3281-4.
2001: Jan Erik Paulsen; Kjell Elgjo
Effect of tumour size on the in vivo growth inhibition of human colon carcinoma cells (HT-29) by colon mitosis inhibitor.
In vivo (Athens, Greece) 2001;15(5):397-401.
2001: Jan Erik Paulsen; Inger-Lise Steffensen; Else Marit Løberg; Trine Husøy; Ellen Namork; Jan Alexander
Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon.
Cancer research 2001;61(13):5010-5.
2001: Rose Vikse; Inger-Lise Steffensen; Jan Erik Paulsen; Jan Alexander
Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele.
Mutagenesis 2001;16(4):309-15.
2000: Jan Erik Paulsen; C Lützow-Holm
In vivo growth inhibition of human colon carcinoma cells (HT-29) by all-trans-retinoic acid, difluoromethylornithine, and colon mitosis inhibitor, individually and in combination.
Anticancer research 2000;20(5B):3485-9.
2000: Jan Erik Paulsen; R C Fulland; Jan Alexander
Age-dependent induction of aberrant crypt foci in rat colon by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and azoxymethane.
Pharmacology & toxicology 2000;87(2):69-73.
2000: Inger-Lise Steffensen; Adrian J Fretland; Jan Erik Paulsen; Yi Feng; Tor Jacob Eide; Uday S Devanaboyina; David W Hein; Jan Alexander
DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
Pharmacology & toxicology 2000;86(6):257-63.
2000: Jan Erik Paulsen; Ellen Namork; Inger-Lise Steffensen; Tor Jacob Eide; Jan Alexander
Identification and quantification of aberrant crypt foci in the colon of Min mice--a murine model of familial adenomatous polyposis.
Scandinavian journal of gastroenterology 2000;35(5):534-9.
2000: Jan Erik Paulsen
Modulation by dietary factors in murine FAP models.
Toxicology letters 2000;112-113():403-9.
1999: J Kristinsson; AG Røseth; A Sundset; Knut Nygaard; Else Marit Løberg; Jan Erik Paulsen; Erling Aadland; Magne Kristoffer Fagerhol
Granulocyte marker protein is increased in stools from rats with azoxymethane-induced colon cancer.
Scandinavian journal of gastroenterology 1999;34(12):1216-23.
1999: Inger-Lise Steffensen; Jan Erik Paulsen; D Engeset; L Kronberg; Jan Alexander
The drinking water chlorination by-products 3,4-dichloro-5-hydroxy-2[5H]-furanone(mucochloric acid) and 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone do not induce preneoplastic or neoplastic intestinal lesions in F344 rats, balb/ca mice or C57bl/6J-min mice.
Pharmacology & toxicology 1999;85(2):56-64.
1999: Jan Erik Paulsen; Inger-Lise Steffensen; Ashild Andreassen; Rose Vikse; Jan Alexander
Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.
Carcinogenesis 1999;20(7):1277-82.
1999: Rose Vikse; Ragnhild Reistad; Inger-Lise Steffensen; Jan Erik Paulsen; S H Nyholm; Jan Alexander
[Heterocyclic amines in cooked meat].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1999;119(1):45-9.
1998: Jan Erik Paulsen; T Stamm; Jan Alexander
A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon.
Pharmacology & toxicology 1998;82(1):28-33.
1998: Dmitry S Gembitsky; Karl L Reichelt; P Haakonsen; Jan Erik Paulsen; Kjell Elgjo
Identification of a melanocyte growth-inhibiting tripeptide and determination of its structure.
The journal of peptide research : official journal of the American Peptide Society 1998;51(1):80-4.
1997: Jan Erik Paulsen; I K Elvsaas; Inger-Lise Steffensen; Jan Alexander
A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse.
Carcinogenesis 1997;18(10):1905-10.
1997: Jan Erik Paulsen; Ragnhild Reistad; K A Eliassen; OV Sjaastad; Jan Alexander
Dietary polyamines promote the growth of azoxymethane-induced aberrant crypt foci in rat colon.
Carcinogenesis 1997;18(10):1871-5.
1997: Inger-Lise Steffensen; Jan Erik Paulsen; Jan Alexander
[Genetic and environmental factors in colorectal cancer. Mutations in the familial adenomatous polyposis gene].
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række 1997;117(14):2046-51.
1997: Inger-Lise Steffensen; Jan Erik Paulsen; Tor Jacob Eide; Jan Alexander
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases the numbers of tumors, cystic crypts and aberrant crypt foci in multiple intestinal neoplasia mice.
Carcinogenesis 1997;18(5):1049-54.
1996: Jan Erik Paulsen; Inger-Lise Steffensen; Ellen Namork; D W Hein; Jan Alexander
Effect of acetylator genotype on 3,2'-dimethyl-4-aminobiphenyl induced aberrant crypt foci in the colon of hamsters.
Carcinogenesis 1996;17(3):459-65.
1995: Inger-Lise Steffensen; Jan Erik Paulsen; Jan Alexander
Unexpected antagonistic action of 3,2'-dimethyl-4-aminobiphenyl on aberrant crypt induction by 1,2-dimethylhydrazine or azoxymethane in rat colon.
Carcinogenesis 1995;16(12):2981-8.
1994: Jan Erik Paulsen; Inger-Lise Steffensen; Ellen Namork; Jan Alexander
Scanning electron microscopy of aberrant crypt foci in rat colon.
Carcinogenesis 1994;15(10):2371-3.