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Jürgen Pauluhn

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Fangfang Liu; Jürgen Pauluhn; Hubert Trübel; Wenli Li; Chen Wang
Lipopolysaccharide-induced acute lung injury in rats: comparative assessment of intratracheal instillation and aerosol inhalation.
Wenli Li; Fangfang Liu; Hubert Truebel; Chen Wang; Jürgen Pauluhn
Novel insights into phosgene-induced acute lung injury in rats: role of dysregulated cardiopulmonary reflexes and nitric oxide in lung edema pathogenesis.
Jürgen Pauluhn
Subchronic inhalation toxicity of iron oxide (magnetite, Fe(3) O(4) ) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles.

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2013: Fangfang Liu; Jürgen Pauluhn; Hubert Trübel; Wenli Li; Chen Wang
Lipopolysaccharide-induced acute lung injury in rats: comparative assessment of intratracheal instillation and aerosol inhalation.
Toxicology 2013;304():158-66.
2013: Wenli Li; Fangfang Liu; Hubert Truebel; Chen Wang; Jürgen Pauluhn
Novel insights into phosgene-induced acute lung injury in rats: role of dysregulated cardiopulmonary reflexes and nitric oxide in lung edema pathogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(2):612-28.
2012: Jürgen Pauluhn
Subchronic inhalation toxicity of iron oxide (magnetite, Fe(3) O(4) ) in rats: pulmonary toxicity is determined by the particle kinetics typical of poorly soluble particles.
Journal of applied toxicology : JAT 2012;32(7):488-504.
2011: Jürgen Pauluhn
Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology.
Regulatory toxicology and pharmacology : RTP 2011;61(3):351-64.
2011: Wen-li Li; Chun-xu Hai; Jürgen Pauluhn
Inhaled nitric oxide aggravates phosgene model of acute lung injury.
Inhalation toxicology 2011;23(13):842-52.
2011: Jürgen Pauluhn; Martin Wiemann
Siderite (FeCO₃) and magnetite (Fe₃O₄) overload-dependent pulmonary toxicity is determined by the poorly soluble particle not the iron content.
Inhalation toxicology 2011;23(13):763-83.
2011: Jürgen Pauluhn; Alan Poole
Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): determination of the elicitation threshold concentration of after inhalation sensitization.
Toxicology 2011;281(1-3):15-24.
2011: Jürgen Pauluhn
Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation.
Toxicology 2011;279(1-3):176-88.
2011: Jürgen Pauluhn; Chun Xue Hai
Attempts to counteract phosgene-induced acute lung injury by instant high-dose aerosol exposure to hexamethylenetetramine, cysteine or glutathione.
Inhalation toxicology 2011;23(1):58-64.
2010: Wen-Li Li; Jürgen Pauluhn
Comparative assessment of the sensory irritation potency in mice and rats nose-only exposed to ammonia in dry and humidified atmospheres.
Toxicology 2010;276(2):135-42.
2010: Jürgen Pauluhn
Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures.
Toxicological sciences : an official journal of the Society of Toxicology 2010;113(1):226-42.
2009: Heidrun Ellinger-Ziegelbauer; Jürgen Pauluhn
Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period.
Toxicology 2009;266(1-3):16-29.
2009: Jürgen Pauluhn
Comparative pulmonary response to inhaled nanostructures: considerations on test design and endpoints.
Inhalation toxicology 2009;21 Suppl 1():40-54.
2009: Jürgen Pauluhn
Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area.
Toxicology 2009;259(3):140-8.
2009: Jürgen Pauluhn
Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size.
Toxicological sciences : an official journal of the Society of Toxicology 2009;109(1):152-67.
2008: Jürgen Pauluhn
Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): analysis of the elicitation dose-response relationship.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):320-31.
2008: Jürgen Pauluhn
Inhalation toxicology: methodological and regulatory challenges.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2008;60(2-3):111-24.
2008: Jürgen Pauluhn
Comparative assessment of early acute lung injury in mice and rats exposed to 1,6-hexamethylene diisocyanate-polyisocyanate aerosols.
Toxicology 2008;247(1):33-45.
2008: Jürgen Pauluhn
Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction.
Regulatory toxicology and pharmacology : RTP 2008;50(1):144-54.
2007: Jürgen Pauluhn; Achim Thiel
A simple approach to validation of directed-flow nose-only inhalation chambers.
Journal of applied toxicology : JAT 2007;27(2):160-7.
2006: Jürgen Pauluhn; Hans-Werner Vohr
Partial C-fiber ablation modulates diphenylmethane-4,4'-diisocyanate (MDI)-induced respiratory allergy in Brown Norway rats.
Toxicology 2006;228(2-3):188-99.
2006: Jürgen Pauluhn
Subacute inhalation toxicity of 2-chloro-4-toluidine in rats.
Inhalation toxicology 2006;18(14):1117-34.
2006: Jürgen Pauluhn
Acute head-only exposure of dogs to phosgene. Part III. Comparison of indicators of lung injury in dogs and rats.
Inhalation toxicology 2006;18(9):609-21.
2006: Jürgen Pauluhn
Acute nose-only exposure of rats to phosgene. Part II. Concentration x time dependence of changes in bronchoalveolar lavage during a follow-up period of 3 months.
Inhalation toxicology 2006;18(9):595-607.
2006: Jürgen Pauluhn; William E Brown; Paul Hext; Edgar Leibold; Gabriele Leng
Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct.
Toxicology 2006;222(3):202-12.
2006: Jürgen Pauluhn
Acute nose-only exposure of rats to phosgene. Part I: concentration x time dependence of LC50s, nonlethal-threshold concentrations, and analysis of breathing patterns.
Inhalation toxicology 2006;18(6):423-35.
2006: Jürgen Pauluhn; Ulrich Mohr
Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats.
Journal of applied toxicology : JAT 2006;26(3):279-92.
2006: Jürgen Pauluhn
Mosquito coil smoke inhalation toxicity. Part I: validation of test approach and acute inhalation toxicity.
Journal of applied toxicology : JAT 2006;26(3):269-78.
2006: Paul J A Borm; Frederick C Klaessig; Timothy D Landry; Brij Moudgil; Jürgen Pauluhn; Karluss Thomas; Remi Trottier; Stewart Wood
Research strategies for safety evaluation of nanomaterials, part V: role of dissolution in biological fate and effects of nanoscale particles.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):23-32.
2005: Jürgen Pauluhn
Brown Norway rat asthma model of diphenylmethane 4,4'-diisocyanate.
Inhalation toxicology 2005;17(13):729-39.
2005: Jürgen Pauluhn
Concentration-dependence of aniline-induced methemoglobinemia in dogs: a derivation of an acute reference concentration.
Toxicology 2005;214(1-2):140-50.
2005: Michaela Aufderheide; Daniel L Costa; Robert Devlin; Victor Feron; Jack R Harkema; Yuzo Hayashi; Jürgen Pauluhn; Horst Spielmann
Experimental Assessment of the Toxicological Effects of Inhaled Complex Mixtures on the Respiratory System, 23-25 April 2005, Barcelona, Spain. Summary and conclusions of the review committee.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2005;57 Suppl 1():239-43.
2005: Jürgen Pauluhn
Overview of inhalation exposure techniques: strengths and weaknesses.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2005;57 Suppl 1():111-28.
2005: Jürgen Pauluhn
Retrospective analysis of acute inhalation toxicity studies: comparison of actual concentrations by filter and cascade impactor analyses.
Regulatory toxicology and pharmacology : RTP 2005;42(2):236-44.
2005: Jürgen Pauluhn; Ulrich Mohr
Experimental approaches to evaluate respiratory allergy in animal models.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2005;56(4-5):203-34.
2005: Jürgen Pauluhn; M R Woolhiser; L Bloemen
Repeated inhalation challenge with diphenylmethane-4,4'-diisocyanate in brown Norway rats leads to a time-related increase of neutrophils in bronchoalveolar lavage after topical induction.
Inhalation toxicology 2005;17(2):67-78.
2005: Jürgen Pauluhn
Inhaled cationic amphiphilic drug-induced pulmonary phospholipidosis in rats and dogs: time-course and dose-response of biomarkers of exposure and effect.
Toxicology 2005;207(1):59-72.
2004: Jürgen Pauluhn
Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):198-215.
2004: Jürgen Pauluhn
Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage.
Journal of applied toxicology : JAT 2004;24(3):231-47.
2004: Jürgen Pauluhn
Acute inhalation studies with irritant aerosols: technical issues and relevance for risk characterization.
Archives of toxicology 2004;78(5):243-51.
2004: Jürgen Pauluhn
Comparative analysis of pulmonary irritation by measurements of Penh and protein in bronchoalveolar lavage fluid in brown Norway rats and Wistar rats exposed to irritant aerosols.
Inhalation toxicology 2004;16(3):159-75.
2003: Jürgen Pauluhn
Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: analysis of dose-response following topical induction and time course following repeated inhalation challenge.
Toxicology 2003;194(1-2):1-17.
2003: Jürgen Pauluhn; M Emura; Ulrich Mohr; Martin Rosenbruch
Inhalation toxicity of propineb. Part II: Results of mechanistic studies in rats.
Inhalation toxicology 2003;15(5):435-60.
2003: Jürgen Pauluhn; Martin Rosenbruch
Inhalation toxicity of propineb. Part I: Results of subacute inhalation exposure studies in rats.
Inhalation toxicology 2003;15(5):411-34.
2003: Jürgen Pauluhn
Issues of dosimetry in inhalation toxicity.
Toxicology letters 2003;140-141():229-38.
2003: Jürgen Pauluhn
Overview of testing methods used in inhalation toxicity: from facts to artifacts.
Toxicology letters 2003;140-141():183-93.
2003: Jürgen Pauluhn; Gabriele Leng
Concentration-dependence of biomarkers of exposure of methylenediphenyl-diisocyanate following acute inhalation exposure of rats.
Toxicology 2003;185(1-2):35-48.
2003: Jürgen Pauluhn; Gabriele Schmuck
Critical analysis of potential body temperature confounders on neurochemical endpoints caused by direct dosing and maternal separation in neonatal mice: a study of bioallethrin and deltamethrin interactions with temperature on brain muscarinic receptors.
Journal of applied toxicology : JAT 2003;23(1):9-18.
2002: Jürgen Pauluhn
Aniline-induced methemoglobinemia in dogs: pitfalls of route-to-route extrapolations.
Inhalation toxicology 2002;14(9):959-73.
2002: Hans-Werner Vohr; Jürgen Pauluhn; Hans-Jürgen Ahr
Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: evidence for different activation pattern of immune cells following topical and respiratory induction.
Archives of toxicology 2002;76(9):538-44.
2002: Jürgen Pauluhn; Jürgen Lewalter
Analysis of markers of exposure to polymeric methylene-diphenyl diisocyanate (pMDI) in rats: a comparison of dermal and inhalation routes of exposure.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2002;54(2):135-46.
2002: Jürgen Pauluhn
Short-term inhalation toxicity of polyisocyanate aerosols in rats: comparative assessment of irritant-threshold concentrations by bronchoalveolar lavage.
Inhalation toxicology 2002;14(3):287-301.
2002: Jürgen Pauluhn; Petra Eidmann; Alexius Freyberger; Grazyna Wasinska-Kempka; Hans-Werner Vohr
Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: a comparison of endpoints.
Journal of applied toxicology : JAT 2002;22(2):89-97.
2002: Jürgen Pauluhn; Petra Eidmann; Ulrich Mohr
Respiratory hypersensitivity in guinea pigs sensitized to 1,6-hexamethylene diisocyanate (HDI): comparison of results obtained with the monomer and homopolymers of HDI.
Toxicology 2002;171(2-3):147-60.
2002: Jürgen Pauluhn
Critical analysis of biomonitoring endpoints for measuring exposure to polymeric diphenyl-methane-4,4'-diisocyanate (MDI) in rats: a comparison of markers of exposure and markers of effect.
Archives of toxicology 2002;76(1):13-22.
2001: Jürgen Pauluhn; Ulrich Mohr
Inhalation toxicity of 4-ethoxyaniline (p-phenetidine): critical analysis of results of subacute inhalation exposure studies in rats.
Inhalation toxicology 2001;13(11):993-1013.
2001: Jürgen Pauluhn; Ulrich Mohr
Inhalation toxicity of 1,6-hexamethylene diisocyanate homopolymers (HDI-IC and HDI-BT): results of subacute and subchronic repeated inhalation exposure studies.
Inhalation toxicology 2001;13(6):513-32.
2001: Jürgen Pauluhn; M Baumann; C Hirth-Dietrich; Martin Rosenbruch
Rat model of lung fibrosis: comparison of functional, biochemical, and histopathological changes 4 months after single irradiation of the right hemithorax.
Toxicology 2001;161(3):153-63.
2000: Jürgen Pauluhn
Inhalation toxicity of 1,6-hexamethylene diisocyanate homopolymer (HDI-IC) aerosol: results of single inhalation exposure studies.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):173-81.
2000: Jürgen Pauluhn; Ulrich Mohr
Inhalation studies in laboratory animals--current concepts and alternatives.
Toxicologic pathology 2000;28(5):734-53.
2000: Jürgen Pauluhn
Acute inhalation toxicity of polymeric diphenyl-methane 4,4'-diisocyanate in rats: time course of changes in bronchoalveolar lavage.
Archives of toxicology 2000;74(4-5):257-69.
2000: Jürgen Pauluhn
Repeated pulmonary function measurements in rats after intratracheal instillation of a polyamine textile pigment component.
Inhalation toxicology 2000;12(7):591-604.
2000: Jürgen Pauluhn; A Thiel; M Emura; Ulrich Mohr
Respiratory sensitization to diphenyl-methane-4,4'-diisocyanate (MDI) in guinea pigs: impact of particle size on induction and elicitation of response.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(1):105-13.
1999: Jürgen Pauluhn; M Emura; Ulrich Mohr; A Popp; Martin Rosenbruch
Two-week inhalation toxicity of polymeric diphenylmethane-4, 4'-diisocyanate (PMDI) in rats: analysis of biochemical and morphological markers of early pulmonary response.
Inhalation toxicology 1999;11(12):1143-63.
1999: Jürgen Pauluhn; R Dearman; J Doe; Paul Hext; T D Landry
Respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate in guinea pigs: comparison with trimellitic anhydride.
Inhalation toxicology 1999;11(3):187-214.
1999: Jürgen Pauluhn; Ulrich Mohr
Repeated 4-week inhalation exposure of rats: effect of low-, intermediate, and high-humidity chamber atmospheres.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999;51(2):178-87.
1998: Jürgen Pauluhn; L H Machemer
Assessment of pyrethroid-induced paraesthesias: comparison of animal model and human data.
Toxicology letters 1998;96-97():361-8.
1997: Gabriele Leng; A Leng; KH Kühn; Jürgen Lewalter; Jürgen Pauluhn
Human dose-excretion studies with the pyrethroid insecticide cyfluthrin: urinary metabolite profile following inhalation.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(12):1273-83.
1997: Jürgen Pauluhn
Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: improvements on analysis of respiratory response.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1997;40(2):211-9.
1994: Jürgen Pauluhn
Assessment of chemicals for their potential to induce respiratory allergy in guinea pigs: A comparison of different routes of induction and confounding effects due to pulmonary hyperreactivity.
Toxicology in vitro : an international journal published in association with BIBRA 1994;8(5):981-5.