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Petrus Pauwels

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Peter Heusler; Petrus J Pauwels; Thierry Wurch; Adrian Newman-Tancredi; Jan Tytgat; Francis C Colpaert; Didier Cussac
Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling.
Thierry Wurch; Petrus J Pauwels
Modulation of 5-HT(1A) receptor-mediated Ca(2+) responses by co-expression with various recombinant G(alpha) proteins in CHO-K1 cells.
Lucien Gazi; Thierry Wurch; Juan F Lopéz-Giménez; Petrus J Pauwels; Philip G Strange
Pharmacological analysis of a dopamine D(2Short):G(alphao) fusion protein expressed in Sf9 cells.

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2005: Peter Heusler; Petrus J Pauwels; Thierry Wurch; Adrian Newman-Tancredi; Jan Tytgat; Francis C Colpaert; Didier Cussac
Differential ion current activation by human 5-HT(1A) receptors in Xenopus oocytes: evidence for agonist-directed trafficking of receptor signalling.
Neuropharmacology 2005;49(7):963-76.
2003: Thierry Wurch; Petrus J Pauwels
Modulation of 5-HT(1A) receptor-mediated Ca(2+) responses by co-expression with various recombinant G(alpha) proteins in CHO-K1 cells.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(2):99-105.
2003: Lucien Gazi; Thierry Wurch; Juan F Lopéz-Giménez; Petrus J Pauwels; Philip G Strange
Pharmacological analysis of a dopamine D(2Short):G(alphao) fusion protein expressed in Sf9 cells.
FEBS letters 2003;545(2-3):155-60.
2003: Thierry Wurch; Francis C Colpaert; Petrus J Pauwels
Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists.
Neuropharmacology 2003;44(7):873-81.
2003: Petrus J Pauwels; Isabelle Rauly; Thierry Wurch
Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1015-23.
2003: Elisa A Boutet-Robinet; Frederic FINANA; Thierry Wurch; Petrus J Pauwels; Luc De Vries
Endogenous RGS proteins facilitate dopamine D(2S) receptor coupling to G(alphao) proteins and Ca2+ responses in CHO-K1 cells.
FEBS letters 2003;533(1-3):67-71.
2003: Thierry Wurch; Elisa A Boutet-Robinet; Christiane Palmier; Francis C Colpaert; Petrus J Pauwels
Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs.
The Journal of pharmacology and experimental therapeutics 2003;304(1):380-90.
2002: Francis C Colpaert; Jean-Pierre Tarayre; Wouter Koek; Petrus J Pauwels; Laurent Bardin; X-J Xu; Z Wiesenfeld-Hallin; Cristina Cosi; Elisabeth Carilla-Durand; Marie-Bernadette Assié; Bernard Vacher
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Neuropharmacology 2002;43(6):945-58.
2002: Petrus J Pauwels; Stéphanie Tardif
Enhanced stability of wild-type and constitutively active alpha(2A)-adrenoceptors by ligands with agonist, silent and inverse agonist properties.
Naunyn-Schmiedeberg's archives of pharmacology 2002;366(2):134-41.
2002: Petrus J Pauwels; Isabelle Rauly; Thierry Wurch; Francis C Colpaert
Evidence for protean agonism of RX 831003 at alpha 2A-adrenoceptors by co-expression with different G alpha protein subunits.
Neuropharmacology 2002;42(6):855-63.
2002: Pankaj Bhalla; Hari S Sharma; Thierry Wurch; Petrus J Pauwels; Pramod R Saxena
Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor.
European journal of pharmacology 2002;436(1-2):23-33.
2002: Petrus J Pauwels; Wouter Koek
Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state.
Naunyn-Schmiedeberg's archives of pharmacology 2002;365(1):82-5.
2001: Thierry Wurch; A Matsumoto; Petrus J Pauwels
Agonist-independent and -dependent oligomerization of dopamine D(2) receptors by fusion to fluorescent proteins.
FEBS letters 2001;507(1):109-13.
2001: Thierry Wurch; J Okuda; Petrus J Pauwels
Reciprocal modulation of alpha(2A)-adrenoceptor and G(alpha o) protein states as determined by carboxy-terminal mutagenesis of a G(alpha o) protein.
Molecular pharmacology 2001;60(4):666-73.
2001: Petrus J Pauwels; Stéphanie Tardif; Francis C Colpaert
Differential signalling of both wild-type and Thr(343)Arg dopamine D(2short) receptor by partial agonists in a G-protein-dependent manner.
Biochemical pharmacology 2001;62(6):723-32.
2001: Petrus J Pauwels; Stéphanie Tardif; Thierry Wurch; Francis C Colpaert
Real-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state.
British journal of pharmacology 2001;134(1):88-97.
2001: E A Robinet; Muriel Geurts; Jean-Marie Maloteaux; Petrus J Pauwels
Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA.
Neuroscience letters 2001;307(1):45-8.
2001: P Bhalla; HS Sharma; X Ma; Thierry Wurch; Petrus J Pauwels; Pramod R Saxena
Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor.
British journal of pharmacology 2001;133(6):891-901.
2001: E A Robinet; Thierry Wurch; Petrus J Pauwels
Different regulation of RGS2 mRNA by haloperidol and clozapine.
Neuroreport 2001;12(8):1731-5.
2001: Wouter Koek; Bernard Vacher; Cristina Cosi; Marie-Bernadette Assié; Jean-François Patoiseau; Petrus J Pauwels; Francis C Colpaert
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
European journal of pharmacology 2001;420(2-3):103-12.
2001: Petrus J Pauwels; Thierry Wurch; Stéphanie Tardif; Frederic FINANA; Francis C Colpaert
Analysis of ligand activation of alpha 2-adrenoceptor subtypes under conditions of equal G alpha protein stoichiometry.
Naunyn-Schmiedeberg's archives of pharmacology 2001;363(5):526-36.
2001: Petrus J Pauwels; Stéphanie Tardif; Francis C Colpaert; Thierry Wurch
Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins.
Biochemical pharmacology 2001;61(9):1079-92.
2001: Petrus J Pauwels; Frederic FINANA; Stéphanie Tardif; Thierry Wurch; Francis C Colpaert
Dynamic dopamine-antagonist interactions at recombinant human dopamine D(2short) receptor: dopamine-bound versus antagonist-bound receptor states.
The Journal of pharmacology and experimental therapeutics 2001;297(1):133-40.
2001: Thierry Wurch; Petrus J Pauwels
Analytical pharmacology of G protein-coupled receptors by stoichiometric expression of the receptor and G(alpha) protein subunits.
Journal of pharmacological and toxicological methods 2001;45(1):3-16.
2001: DS Dupuis; Thierry Wurch; Stéphanie Tardif; Francis C Colpaert; Petrus J Pauwels
Modulation of 5-HT(1A) receptor activation by its interaction with wild-type and mutant g(alphai3) proteins.
Neuropharmacology 2001;40(1):36-47.
2000: Petrus J Pauwels
Diverse signalling by 5-hydroxytryptamine (5-HT) receptors.
Biochemical pharmacology 2000;60(12):1743-50.
2000: Petrus J Pauwels; Francis C Colpaert
Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions.
British journal of pharmacology 2000;131(7):1385-90.
2000: P Bhalla; HS Sharma; Thierry Wurch; Petrus J Pauwels; Pramod R Saxena
Molecular cloning, sequence analysis and pharmacological properties of the porcine 5-HT(1D) receptor.
British journal of pharmacology 2000;131(5):949-57.
2000: P Mayer; P Brunel; C Chaplain; C Piedecoq; F Calmel; Philippe Schambel; Philippe Chopin; Thierry Wurch; Petrus J Pauwels; Marc Marien; J L Vidaluc; T Imbert
New substituted 1-(2,3-dihydrobenzo[1, 4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with alpha(2)-adrenoceptor antagonist activity.
Journal of medicinal chemistry 2000;43(20):3653-64.
2000: Thierry Wurch; Petrus J Pauwels
Coupling of canine serotonin 5-HT(1B) and 5-HT(1D) receptor subtypes to the formation of inositol phosphates by dual interactions with endogenous G(i/o) and recombinant G(alpha15) proteins.
Journal of neurochemistry 2000;75(3):1180-9.
2000: Petrus J Pauwels; Francis C Colpaert
Heterogeneous ligand-mediated Ca(++) responses at wt and mutant alpha(2A)-adrenoceptors suggest multiple ligand activation binding sites at the alpha(2A)-adrenoceptor.
Neuropharmacology 2000;39(11):2101-11.
2000: Petrus J Pauwels; Francis C Colpaert
Disparate ligand-mediated Ca(2+) responses by wild-type, mutant Ser(200)Ala and Ser(204)Ala alpha(2A)-adrenoceptor: G(alpha15) fusion proteins: evidence for multiple ligand-activation binding sites.
British journal of pharmacology 2000;130(7):1505-12.
2000: Isabelle Rauly; M Ailhaud; Thierry Wurch; Petrus J Pauwels
alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway.
Biochemical pharmacology 2000;59(12):1531-8.
2000: Bruno Le Grand; A Panissié; Michel Perez; Petrus J Pauwels; Gareth W John
Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors.
European journal of pharmacology 2000;397(2-3):297-302.
2000: Petrus J Pauwels; Frederic FINANA; Stéphanie Tardif; Francis C Colpaert; Thierry Wurch
Agonist efficacy at the alpha2A-adrenoceptor:G alpha15 fusion protein: an analysis based on Ca2+ responses.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(6):672-9.
2000: Thierry Wurch; Christiane Palmier; Petrus J Pauwels
Induction of a high-affinity ketanserin binding site at the 5-Hydroxytryptamine(1B) receptor by modification of its carboxy-terminal intracellular portion.
Biochemical pharmacology 2000;59(9):1117-21.
2000: Petrus J Pauwels; Stéphanie Tardif; Thierry Wurch; Francis C Colpaert
Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism.
The Journal of pharmacology and experimental therapeutics 2000;292(2):654-63.
2000: Petrus J Pauwels; Stéphanie Tardif; Frederic FINANA; Thierry Wurch; Francis C Colpaert
Ligand-receptor interactions as controlled by wild-type and mutant Thr(370)Lys alpha2B-adrenoceptor-Galpha15 fusion proteins.
Journal of neurochemistry 2000;74(1):375-84.
1999: Petrus J Pauwels; A Gouble; Thierry Wurch
Activation of constitutive 5-hydroxytryptamine(1B) receptor by a series of mutations in the BBXXB motif: positioning of the third intracellular loop distal junction and its G(o)alpha protein interactions.
The Biochemical journal 1999;343 Pt 2():435-42.
1999: DS Dupuis; Stéphanie Tardif; Thierry Wurch; Francis C Colpaert; Petrus J Pauwels
Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein.
Neuropharmacology 1999;38(7):1035-41.
1999: Gareth W John; Petrus J Pauwels; Michel Perez; Serge Halazy; Bruno Le Grand; Yvan Verscheure; JP Valentin; Christiane Palmier; Thierry Wurch; Philippe Chopin; Marc Marien; Mark S Kleven; Wouter Koek; M B Assie; Elisabeth Carilla-Durand; Jean-Pierre Tarayre; Francis C Colpaert
F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.
The Journal of pharmacology and experimental therapeutics 1999;290(1):83-95.
1999: Petrus J Pauwels; Gareth W John
Present and future of 5-HT receptor agonists as antimigraine drugs.
Clinical neuropharmacology 1999;22(3):123-36.
1999: DS Dupuis; Petrus J Pauwels; D Radu; H Hall
Autoradiographic studies of 5-HT1A-receptor-stimulated [35S]GTPgammaS-binding responses in the human and monkey brain.
The European journal of neuroscience 1999;11(5):1809-17.
1999: DS Dupuis; Michel Perez; Serge Halazy; Francis C Colpaert; Petrus J Pauwels
Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses.
Brain research. Molecular brain research 1999;67(1):107-23.
1999: Thierry Wurch; Francis C Colpaert; Petrus J Pauwels
G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors.
British journal of pharmacology 1999;126(4):939-48.
1998: Bruno Le Grand; A Panissié; Petrus J Pauwels; Gareth W John
Activation of recombinant h 5-HT1B and h 5-HT1D receptors stably expressed in C6 glioma cells produces increases in Ca2+-dependent K+ current.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(6):608-15.
1998: Michel Perez; Petrus J Pauwels; I Pallard-Sigogneau; C Fourrier; Philippe Chopin; Christiane Palmier; V Colovray; Serge Halazy
Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.
Bioorganic & medicinal chemistry letters 1998;8(23):3423-8.
1998: Thierry Wurch; Francis C Colpaert; Petrus J Pauwels
Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding.
Molecular pharmacology 1998;54(6):1088-96.
1998: Petrus J Pauwels; DS Dupuis; Michel Perez; Serge Halazy
Dimerization of 8-OH-DPAT increases activity at serotonin 5-HT1A receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(4):404-10.
1998: Wouter Koek; Jean-François Patoiseau; Marie-Bernadette Assié; Cristina Cosi; Mark S Kleven; Elisabeth Dupont-Passelaigue; Elisabeth Carilla-Durand; Christiane Palmier; JP Valentin; G John; Petrus J Pauwels; Jean-Pierre Tarayre; Francis C Colpaert
F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.
The Journal of pharmacology and experimental therapeutics 1998;287(1):266-83.
1998: T Barf; Håkan V Wikström; Petrus J Pauwels; Christiane Palmier; Stéphanie Tardif; M Lundmark; Staffan Sundell
5-(Sulfonyl)oxy-tryptamines and ethylamino side chain restricted derivatives. Structure-affinity relationships for h5-HT1B and h5-HT1D receptors.
Bioorganic & medicinal chemistry 1998;6(9):1469-79.
1998: Michel Perez; C Jorand-Lebrun; Petrus J Pauwels; I Pallard; Serge Halazy
Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes.
Bioorganic & medicinal chemistry letters 1998;8(11):1407-12.
1998: Petrus J Pauwels; Christiane Palmier; DS Dupuis; Francis C Colpaert
Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(5):490-9.
1998: DS Dupuis; Francis C Colpaert; Petrus J Pauwels
G-protein activation at 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines.
British journal of pharmacology 1998;124(2):283-90.
1998: Michel Perez; Petrus J Pauwels; C Fourrier; Philippe Chopin; JP Valentin; Gareth W John; Marc Marien; Serge Halazy
Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.
Bioorganic & medicinal chemistry letters 1998;8(6):675-80.
1998: DS Dupuis; Christiane Palmier; Francis C Colpaert; Petrus J Pauwels
Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding.
Journal of neurochemistry 1998;70(3):1258-68.
1998: Petrus J Pauwels; Thierry Wurch
Review: amino acid domains involved in constitutive activation of G-protein-coupled receptors.
Molecular neurobiology 1998;17(1-3):109-35.
1998: Petrus J Pauwels
Na(+)-dependent metabolic coupling upon 5-HT1B receptor activation by sumatriptan and related agonists.
Receptors & channels 1998;5(6):367-73.
1998: Petrus J Pauwels; Thierry Wurch; Christiane Palmier; Francis C Colpaert
Pharmacological analysis of G-protein activation mediated by guinea-pig recombinant 5-HT1B receptors in C6-glial cells: similarities with the human 5-HT1B receptor.
British journal of pharmacology 1998;123(1):51-62.
1997: C Jorand-Lebrun; Petrus J Pauwels; Christiane Palmier; C Moret; Philippe Chopin; Michel Perez; Marc Marien; Serge Halazy
5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
Journal of medicinal chemistry 1997;40(24):3974-8.
1997: Petrus J Pauwels; Stéphanie Tardif; Thierry Wurch; Francis C Colpaert
Stimulated [35S]GTP gamma S binding by 5-HT1A receptor agonists in recombinant cell lines. Modulation of apparent efficacy by G-protein activation state.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(5):551-61.
1997: Petrus J Pauwels
Competitive and silent antagonism of recombinant 5-HT1B receptors by amiloride.
General pharmacology 1997;29(5):749-51.
1997: Marie Lamothe; Petrus J Pauwels; K Belliard; Philippe Schambel; Serge Halazy
Differentiation between partial agonists and neutral 5-HT1B antagonists by chemical modulation of 3-[3-(N,N-dimethylamino)propyl]-4-hydroxy- N-[4-(pyridin-4-yl)phenyl]benzamide (GR-55562).
Journal of medicinal chemistry 1997;40(22):3542-50.
1997: Petrus J Pauwels
5-HT 1B/D receptor antagonists.
General pharmacology 1997;29(3):293-303.
1997: Petrus J Pauwels; Stéphanie Tardif; Christiane Palmier; Thierry Wurch; Francis C Colpaert
How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines.
Neuropharmacology 1997;36(4-5):499-512.
1997: Thierry Wurch; Christiane Palmier; Francis C Colpaert; Petrus J Pauwels
Recombinant saphenous vein 5-HT1B receptors of the rabbit: comparative pharmacology with human 5-HT1B receptors.
British journal of pharmacology 1997;120(1):153-9.
1997: Thierry Wurch; Christiane Palmier; Francis C Colpaert; Petrus J Pauwels
Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors: common pharmacological features within the 5-HT1D receptor subfamily.
Journal of neurochemistry 1997;68(1):410-8.
1996: Serge Halazy; Michel Perez; C Fourrier; I Pallard; Petrus J Pauwels; Christiane Palmier; Gareth W John; JP Valentin; R Bonnafous; J Martinez
Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.
Journal of medicinal chemistry 1996;39(25):4920-7.
1996: Petrus J Pauwels; Thierry Wurch; Christiane Palmier; F C Colpaert
Promotion of cell growth by stimulation of cloned human 5-HT1D receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(2):136-44.
1996: Petrus J Pauwels; F C Colpaert
Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935.
European journal of pharmacology 1996;300(1-2):141-5.
1996: Petrus J Pauwels; F C Colpaert
Stereoselectivity of 8-OH-DPAT enantiomers at cloned human 5-HT1D receptor sites.
European journal of pharmacology 1996;300(1-2):137-9.
1996: Petrus J Pauwels; Christiane Palmier; Thierry Wurch; F C Colpaert
Pharmacology of cloned human 5-HT1D receptor-mediated functional responses in stably transfected rat C6-glial cell lines: further evidence differentiating human 5-HT1D and 5-HT1B receptors.
Naunyn-Schmiedeberg's archives of pharmacology 1996;353(2):144-56.
1996: Petrus J Pauwels; Thierry Wurch; M C Amoureux; Christiane Palmier; F C Colpaert
Stimulation of cloned human serotonin 5-HT1D beta receptor sites in stably transfected C6 glial cells promotes cell growth.
Journal of neurochemistry 1996;66(1):65-73.
1995: M C Amoureux; Thierry Wurch; Petrus J Pauwels
Expression of human metallothionein-III confers protection against serum-free exposure of stably transfected Chinese hamster ovary CHO-K1 cells.
Neuroscience letters 1995;201(1):61-4.
1995: Petrus J Pauwels; F C Colpaert
Differentiation between partial and silent 5-HT1D beta receptor antagonists using rat C6-glial and Chinese hamster ovary cell lines permanently transfected with a cloned human 5-HT1D beta receptor gene.
Biochemical pharmacology 1995;50(10):1651-8.
1995: M C Amoureux; Thierry Wurch; Petrus J Pauwels
Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes.
Biochemical and biophysical research communications 1995;214(2):639-45.
1995: Michel Perez; C Fourrier; I Sigogneau; Petrus J Pauwels; Christiane Palmier; Gareth W John; JP Valentin; Serge Halazy
Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors.
Journal of medicinal chemistry 1995;38(18):3602-7.
1995: Petrus J Pauwels; Christiane Palmier
Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT1D alpha, 5-HT1D beta, 5-HT1A and opossum 5-HT1B receptors.
European journal of pharmacology 1995;290(2):95-103.
1995: Petrus J Pauwels; F C Colpaert
The 5-HT1D receptor antagonist GR 127,935 is an agonist at cloned human 5-HT1D alpha receptor sites.
Neuropharmacology 1995;34(2):235-7.
1994: Petrus J Pauwels; Christiane Palmier
Differential functional activity of 5-hydroxytryptamine receptor ligands and beta adrenergic receptor antagonists at 5-hydroxytryptamine1B receptor sites in Chinese hamster lung fibroblasts and opossum renal epithelial cells.
The Journal of pharmacology and experimental therapeutics 1994;270(3):938-45.
1994: Petrus J Pauwels; Christiane Palmier
Inhibition by 5-HT of forskolin-induced cAMP formation in the renal opossum epithelial cell line OK: mediation by a 5-HT1B like receptor and antagonism by methiothepin.
Neuropharmacology 1994;33(1):67-75.
1993: Petrus J Pauwels; Christiane Palmier; M Briley
Identification of 5-hydroxytryptamine1D binding sites in sheep caudate nucleus membranes.
Biochemical pharmacology 1993;46(3):535-8.
1993: Petrus J Pauwels; H P van Assouw; M De Ryck; Josée E Leysen; R Dom; D Van Gool
Towards an improved survival of rat brain neurons in culture by cerebrospinal fluid of patients with senile dementia of Alzheimer's type.
Brain research 1993;610(1):8-15.
1993: Petrus J Pauwels; P Van Gompel; Josée E Leysen
Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.
Biochemical pharmacology 1993;45(2):375-83.
1993: Josée E Leysen; W Gommeren; J Mertens; Walter H M L Luyten; Petrus J Pauwels; M Ewert; P Seeburg
Comparison of in vitro binding properties of a series of dopamine antagonists and agonists for cloned human dopamine D2S and D2L receptors and for D2 receptors in rat striatal and mesolimbic tissues, using [125I] 2'-iodospiperone.
Psychopharmacology 1993;110(1-2):27-36.
1992: Petrus J Pauwels; H P Van Assouw; L Peeters; M Moeremans; Josée E Leysen
Chronic treatment with sabeluzole protects cultured rat brain neurons from the neurotoxic effects of excitatory amino acids.
Synapse (New York, N.Y.) 1992;12(4):271-80.
1992: Petrus J Pauwels; Josée E Leysen
Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus.
Neuroscience letters 1992;143(1-2):27-30.
1992: Josée E Leysen; P M Janssen; W Gommeren; J Wynants; Petrus J Pauwels; P A Janssen
In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone.
Molecular pharmacology 1992;41(3):494-508.
1991: Petrus J Pauwels; P Van Gompel; Josée E Leysen
Human beta 1- and beta 2-adrenergic receptor binding and mediated accumulation of cAMP in transfected Chinese hamster ovary cells. Profile of nebivolol and known beta-adrenergic blockers.
Biochemical pharmacology 1991;42(9):1683-9.
1991: Petrus J Pauwels; Josée E Leysen; P A Janssen
Ca++ and Na+ channels involved in neuronal cell death. Protection by flunarizine.
Life sciences 1991;48(20):1881-93.
1990: Petrus J Pauwels; H P Van Assouw; L Peeters; Josée E Leysen
Neurotoxic action of veratridine in rat brain neuronal cultures: mechanism of neuroprotection by Ca++ antagonists nonselective for slow Ca++ channels.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1117-22.
1990: M De Ryck; H Duytschaever; Petrus J Pauwels; Paul A J Janssen
Ionic channels, cholinergic mechanisms, and recovery of sensorimotor function after neocortical infarcts in rats.
Stroke; a journal of cerebral circulation 1990;21(11 Suppl):III158-63.
1990: Petrus J Pauwels; P Van Gompel; Josée E Leysen
Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells.
Life sciences 1990;47(22):2009-19.
1990: Josée E Leysen; Petrus J Pauwels
5-HT2 receptors, roles and regulation.
Annals of the New York Academy of Sciences 1990;600():183-91; discussion 192-3.
1989: Petrus J Pauwels; Josée E Leysen; P A Janssen
Beta-adrenoceptor-mediated cAMP accumulation in cardiac cells: effects of nebivolol.
European journal of pharmacology 1989;172(6):471-9.
1989: Petrus J Pauwels; H P Van Assouw; Josée E Leysen; P A Janssen
Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine.
Molecular pharmacology 1989;36(4):525-31.
1989: Petrus J Pauwels; H P van Assouw; Josée E Leysen
Attenuation of neurotoxicity following anoxia or glutamate receptor activation in EGF- and hippocampal extract-treated neuronal cultures.
Cellular signalling 1989;1(1):45-54.
1988: Petrus J Pauwels; W Gommeren; G Van Lommen; P A Janssen; Josée E Leysen
The receptor binding profile of the new antihypertensive agent nebivolol and its stereoisomers compared with various beta-adrenergic blockers.
Molecular pharmacology 1988;34(6):843-51.
1987: Petrus J Pauwels; H P Van Assouw; Josée E Leysen
Depolarization of chick myotubes triggers the appearance of (+)-[3H]PN 200-110-binding sites.
Molecular pharmacology 1987;32(6):785-91.