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Nikola Pavletich

Research Profile

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Genes & Molecular Sequences

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TOP 3
Haijuan Yang; Hyo J Yang; Joseph D Koos; Derek G Rudge; Bhamini Vaidialingam; Nikola P Pavletich
mTOR kinase structure, mechanism and regulation.
Jie Fan; Nikola P Pavletich
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.
Woo Joo; Olga Buzovetsky; Stephen J Elledge; Nicole S Persky; Derek G Rudge; Agata Smogorzewska; Guozhou Xu; Nikola P Pavletich
Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.

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All Publications

2013: Haijuan Yang; Hyo J Yang; Joseph D Koos; Derek G Rudge; Bhamini Vaidialingam; Nikola P Pavletich
mTOR kinase structure, mechanism and regulation.
Nature 2013;497(7448):217-23.
2012: Jie Fan; Nikola P Pavletich
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.
Genes & development 2012;26(20):2337-47.
2011: Woo Joo; Olga Buzovetsky; Stephen J Elledge; Nicole S Persky; Derek G Rudge; Agata Smogorzewska; Guozhou Xu; Nikola P Pavletich
Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.
Science (New York, N.Y.) 2011;333(6040):312-6.
2010: Hiroyuki Takai; Yihu Xie; Titia de Lange; Nikola P Pavletich
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Genes & development 2010;24(18):2019-30.
2009: Zhenjian Cai; Nabil H Chehab; Nikola P Pavletich
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.
Molecular cell 2009;35(6):818-29.
2008: Andrea Scrima; Renata Konícková; Bryan Czyzewski; Yusuke Kawasaki; Philip Jeffrey; Regina Groisman; Yoshihiro Nakatani; Shigenori Iwai; Nikola P Pavletich; Nicolas H Thomä
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell 2008;135(7):1213-23.
2008: Zhucheng Chen; Haijuan Yang; Nikola P Pavletich
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Nature 2008;453(7194):489-4.
2007: Jung-Hyun Min; Nikola P Pavletich
Recognition of DNA damage by the Rad4 nucleotide excision repair protein.
Nature 2007;449(7162):570-5.
2007: Bing Hao; Stephanie Oehlmann; Mathew E Sowa; J Wade Harper; Nikola P Pavletich
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
Molecular cell 2007;26(1):131-43.
2007: Lloyd C Trotman; Xinjiang Wang; Andrea Alimonti; Zhenbang Chen; Julie T Feldstein; Haijuan Yang; Nikola P Pavletich; Brett S Carver; Carlos Cordon-Cardo; Hediye Erdjument-Bromage; Paul Tempst; Sung-Gil Chi; Hyo Jong Kim; Tom Misteli; Xuejun Jiang; Pier Paolo Pandolfi
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Cell 2007;128(1):141-56.
2007: Masha V Poyurovsky; Christina Priest; Alex Kentsis; Katherine L B Borden; Zhen-Qiang Pan; Nikola P Pavletich; Carol Prives
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.
The EMBO journal 2007;26(1):90-101.
2005: Seth M Rubin; Anne-Laure Gall; Ning Zheng; Nikola P Pavletich
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
Cell 2005;123(6):1093-106.
2005: Bing Hao; Ning Zheng; Brenda A Schulman; Geng Wu; Julie J Miller; Michele Pagano; Nikola P Pavletich
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
Molecular cell 2005;20(1):9-19.
2005: Nicolas H Thomä; Bryan Czyzewski; Andrei A Alexeev; Alexander V Mazin; Stephen C Kowalczykowski; Nikola P Pavletich
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.
Nature structural & molecular biology 2005;12(4):350-6.
2005: Haijuan Yang; Qiubai Li; Jie Fan; William K Holloman; Nikola P Pavletich
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction.
Nature 2005;433(7026):653-7.
2005: Ti Li; Nikola P Pavletich; Brenda A Schulman; Ning Zheng
High-level expression and purification of recombinant SCF ubiquitin ligases.
Methods in enzymology 2005;398():125-42.
2004: Yentram Huyen; Philip Jeffrey; W Brent Derry; Joel H Rothman; Nikola P Pavletich; Elena S Stavridi; Thanos D Halazonetis
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1.
Structure (London, England : 1993) 2004;12(7):1237-43.
2004: Raj Misra; Hai-yun Xiao; Kyoung S Kim; Songfeng Lu; Wen-Ching Han; Stephanie A Barbosa; John T Hunt; David B Rawlins; Weifang Shan; Syed Z Ahmed; Ligang Qian; Bang-Chi Chen; Rulin Zhao; Mark S Bednarz; Kristen A Kellar; Janet G Mulheron; Roberta Batorsky; Urvashi Roongta; Amrita V Kamath; Punit Marathe; Sunanda A Ranadive; John S Sack; John S Tokarski; Nikola P Pavletich; Francis Y Lee; Kevin R Webster; S David Kimball
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
Journal of medicinal chemistry 2004;47(7):1719-28.
2003: Cayetano von Kobbe; Nicolas H Thomä; Bryan Czyzewski; Nikola P Pavletich; Vilhelm A Bohr
Werner syndrome protein contains three structure-specific DNA binding domains.
The Journal of biological chemistry 2003;278(52):52997-3006.
2003: Milorad Kojic; Haijuan Yang; Corwin F Kostrub; Nikola P Pavletich; William K Holloman
The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis.
Molecular cell 2003;12(4):1043-9.
2003: Elena S Stavridi; Kimberly G Harris; Yentram Huyen; John Bothos; Peter-Mark Verwoerd; Steve E Stayrook; Nikola P Pavletich; Philip Jeffrey; Francis C Luca
Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways.
Structure (London, England : 1993) 2003;11(9):1163-70.
2003: Geng Wu; Guozhou Xu; Brenda A Schulman; Philip Jeffrey; J Wade Harper; Nikola P Pavletich
Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
Molecular cell 2003;11(6):1445-56.
2003: Jijie Chai; Jia-Wei Wu; Nieng Yan; Joan Massagué; Nikola P Pavletich; Yigong Shi
Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding.
The Journal of biological chemistry 2003;278(22):20327-31.
2002: Jacek Nowakowski; Ciarán N Cronin; Duncan E McRee; Mark W Knuth; Christian G Nelson; Nikola P Pavletich; Joe Rogers; Bi-Ching Sang; Daniel Scheibe; Ron Swanson; Devon A Thompson
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.
Structure (London, England : 1993) 2002;10(12):1659-67.
2002: Haijuan Yang; Philip Jeffrey; Julie Miller; Elspeth Kinnucan; Yutong Sun; Nicolas H Thoma; Ning Zheng; Phang-Lang Chen; Wen-Hwa Lee; Nikola P Pavletich
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science (New York, N.Y.) 2002;297(5588):1837-48.
2002: Kyoung Soon Kim; S David Kimball; Raj Misra; David B Rawlins; John T Hunt; Hai-yun Xiao; Songfeng Lu; Ligang Qian; Wen-Ching Han; Weifang Shan; Toomas Mitt; Zhen-Wei Cai; Michael A Poss; Hong Zhu; John S Sack; John S Tokarski; Chieh Ying Chang; Nikola P Pavletich; Amrita V Kamath; W Griffith Humphreys; Punit Marathe; Isia Bursuker; Kristen A Kellar; Urvashi Roongta; Roberta Batorsky; Janet G Mulheron; David K Bol; Craig R Fairchild; Francis Y Lee; Kevin R Webster
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
Journal of medicinal chemistry 2002;45(18):3905-27.
2002: Elena S Stavridi; Yentram Huyen; Ivy R Loreto; Daniel M Scolnick; Thanos D Halazonetis; Nikola P Pavletich; Philip Jeffrey
Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
Structure (London, England : 1993) 2002;10(7):891-9.
2002: Jung-Hyun Min; Haifeng Yang; Mircea Ivan; Frank Gertler; William G Kaelin; Nikola P Pavletich
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Science (New York, N.Y.) 2002;296(5574):1886-9.
2002: Ning Zheng; Brenda A Schulman; Langzhou Song; Julie J Miller; Philip Jeffrey; Ping Wang; Claire Chu; Deanna M Koepp; Stephen J Elledge; Michele Pagano; Ronald C Conaway; Joan Weliky Conaway; J Wade Harper; Nikola P Pavletich
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature 2002;416(6882):703-9.
2002: Woo S Joo; Philip Jeffrey; Sharon B Cantor; Michael S Finnin; David M Livingston; Nikola P Pavletich
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
Genes & development 2002;16(5):583-93.
2002: Nikola P Pavletich
Structural biology of ubiquitin-protein ligases.
Harvey lectures 2002;98():65-102.
2001: Michael S Finnin; J R Donigian; Nikola P Pavletich
Structure of the histone deacetylase SIRT2.
Nature structural biology 2001;8(7):621-5.
2001: Esther Latres; Roberto Chiarle; Brenda A Schulman; Nikola P Pavletich; A Pellicer; Giorgio Inghirami; Michele Pagano
Role of the F-box protein Skp2 in lymphomagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2515-20.
2001: Jonathan C Hagopian; M P Kirtley; L M Stevenson; R M Gergis; A A Russo; Nikola P Pavletich; Stanley M Parsons; John Lew
Kinetic basis for activation of CDK2/cyclin A by phosphorylation.
The Journal of biological chemistry 2001;276(1):275-80.
2000: Maria-Magdalena Georgescu; Kathrin Kirsch; Paul Kaloudis; Haijuan Yang; Nikola P Pavletich; Hidesaburo Hanafusa
Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.
Cancer research 2000;60(24):7033-8.
2000: Philip Jeffrey; L Tong; Nikola P Pavletich
Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.
Genes & development 2000;14(24):3115-25.
2000: Brenda A Schulman; Andrea C. Carrano; Philip Jeffrey; Z Bowen; Elspeth Kinnucan; Michael S Finnin; Stephen J Elledge; J Wade Harper; Michele Pagano; Nikola P Pavletich
Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature 2000;408(6810):381-6.
2000: Ning Zheng; Ping Wang; Philip Jeffrey; Nikola P Pavletich
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell 2000;102(4):533-9.
2000: Michael Ohh; C W Park; Mircea Ivan; M A Hoffman; T Y Kim; L E Huang; Nikola P Pavletich; Vincent Chau; William G Kaelin
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.
Nature cell biology 2000;2(7):423-7.
2000: Shengkan Jin; S Martinek; W S Joo; Jennifer Wortman; Nebojsa Mirkovic; Andrej Sali; M D Yandell; Nikola P Pavletich; Michael W Young; Arnold J Levine
Identification and characterization of a p53 homologue in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7301-6.
1999: Michael Ohh; Y Takagi; T Aso; CE Stebbins; Nikola P Pavletich; B Zbar; Ronald C Conaway; Joan Weliky Conaway; William G Kaelin
Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.
The Journal of clinical investigation 1999;104(11):1583-91.
1999: L Huang; Elspeth Kinnucan; G Wang; Sylvie Beaudenon; Peter M Howley; Jon M Huibregtse; Nikola P Pavletich
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Science (New York, N.Y.) 1999;286(5443):1321-6.
1999: JO Lee; Haijuan Yang; Maria-Magdalena Georgescu; Antonio Di Cristofano; T Maehama; Y Shi; J E Dixon; Pier Paolo Pandolfi; Nikola P Pavletich
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Cell 1999;99(3):323-34.
1999: Michael S Finnin; J R Donigian; A Cohen; Victoria M Richon; Richard A Rifkind; Paul A Marks; Ronald Breslow; Nikola P Pavletich
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
Nature 1999;401(6749):188-93.
1999: Nikola P Pavletich
Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors.
Journal of molecular biology 1999;287(5):821-8.
1999: CE Stebbins; William G Kaelin; Nikola P Pavletich
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Science (New York, N.Y.) 1999;284(5413):455-61.
1999: N Zheng; Ernest Fraenkel; Carl O Pabo; Nikola P Pavletich
Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.
Genes & development 1999;13(6):666-74.
1998: Wolfgang M J Obermann; Holger Sondermann; A A Russo; Nikola P Pavletich; F Ulrich Hartl
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.
The Journal of cell biology 1998;143(4):901-10.
1998: A A Russo; L Tong; JO Lee; Philip Jeffrey; Nikola P Pavletich
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature 1998;395(6699):237-43.
1998: Yigong Shi; Y F Wang; L Jayaraman; H Yang; Joan Massagué; Nikola P Pavletich
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
Cell 1998;94(5):585-94.
1998: Philipp Kaldis; A A Russo; H S Chou; Nikola P Pavletich; Mark J Solomon
Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities.
Molecular biology of the cell 1998;9(9):2545-60.
1998: YG Chen; Akiko Hata; RS Lo; David Wotton; Y Shi; Nikola P Pavletich; Joan Massagué
Determinants of specificity in TGF-beta signal transduction.
Genes & development 1998;12(14):2144-52.
1998: JO Lee; A A Russo; Nikola P Pavletich
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7.
Nature 1998;391(6670):859-65.
1998: RS Lo; YG Chen; Y Shi; Nikola P Pavletich; Joan Massagué
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.
The EMBO journal 1998;17(4):996-1005.
1997: Y Shi; Akiko Hata; RS Lo; Joan Massagué; Nikola P Pavletich
A structural basis for mutational inactivation of the tumour suppressor Smad4.
Nature 1997;388(6637):87-93.
1997: CE Stebbins; A A Russo; C Schneider; N Rosen; F U Hartl; Nikola P Pavletich
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Cell 1997;89(2):239-50.
1996: P H Kussie; S Gorina; Vincent Marechal; B Elenbaas; J Moreau; Arnold J Levine; Nikola P Pavletich
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science (New York, N.Y.) 1996;274(5289):948-53.
1996: S Gorina; Nikola P Pavletich
Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
Science (New York, N.Y.) 1996;274(5289):1001-5.
1996: A A Russo; Philip Jeffrey; Nikola P Pavletich
Structural basis of cyclin-dependent kinase activation by phosphorylation.
Nature structural biology 1996;3(8):696-700.
1996: A A Russo; Philip Jeffrey; A K Patten; Joan Massagué; Nikola P Pavletich
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature 1996;382(6589):325-31.
1995: Philip Jeffrey; A A Russo; Kornelia Polyak; E Gibbs; Jerard Hurwitz; Joan Massagué; Nikola P Pavletich
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature 1995;376(6538):313-20.
1995: Philip Jeffrey; S Gorina; Nikola P Pavletich
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms.
Science (New York, N.Y.) 1995;267(5203):1498-502.
1995: L Wu; J H Bayle; B Elenbaas; Nikola P Pavletich; Arnold J Levine
Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids.
Molecular and cellular biology 1995;15(1):497-504.
1994: Y Cho; S Gorina; Philip Jeffrey; Nikola P Pavletich
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.
Science (New York, N.Y.) 1994;265(5170):346-55.
1994: Carol Prives; J Bargonetti; G Farmer; E Ferrari; P Friedlander; Y Wang; L Jayaraman; Nikola P Pavletich; U Hubscher
DNA-binding properties of the p53 tumor suppressor protein.
Cold Spring Harbor symposia on quantitative biology 1994;59():207-13.
1993: Nikola P Pavletich; K A Chambers; Carl O Pabo
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.
Genes & development 1993;7(12B):2556-64.
1993: Nikola P Pavletich; Carl O Pabo
Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
Science (New York, N.Y.) 1993;261(5129):1701-7.
1991: Nikola P Pavletich; Carl O Pabo
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A.
Science (New York, N.Y.) 1991;252(5007):809-17.