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Tony Pawson

Research Profile

Physiology

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Mouse

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Publications

TOP 3
James D R Knight; Tony Pawson; Anne-Claude Gingras
Profiling the kinome: current capabilities and future challenges.
Ruijun Tian; Jing Jin; Brett Larsen; Susan E Quaggin; Lorne Taylor; Tony Pawson
Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions.
Antoine Reginensi; Rizaldy P Scott; Jeff Wrana; Tony Pawson; Mazdak Bagherie-Lachidan; Chaeuk Chung; Alex Gregorieff; Dae-Sik Lim; Helen McNeill
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.

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All Publications

2013: James D R Knight; Tony Pawson; Anne-Claude Gingras
Profiling the kinome: current capabilities and future challenges.
Journal of proteomics 2013;81():43-55.
2013: Ruijun Tian; Jing Jin; Brett Larsen; Susan E Quaggin; Lorne Taylor; Tony Pawson
Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions.
Proteomics 2013;13(8):1334-8.
2013: Antoine Reginensi; Rizaldy P Scott; Jeff Wrana; Tony Pawson; Mazdak Bagherie-Lachidan; Chaeuk Chung; Alex Gregorieff; Dae-Sik Lim; Helen McNeill
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.
PLoS genetics 2013;9(3):e1003380.
2013: Greg M Findlay; Gerald Gish; Marilyn S Hsiung; Haiming Huang; Mitsuhiko Ikura; Tomonori Kaneko; Troy Ketela; Fredrik Lanner; Shawn S-C Li; Jason Moffat; Evangelia Petsalaki; Janet Rossant; Sachdev S Sidhu; Matthew J Smith; Lorne Taylor; Monika Tucholska; Richard D Bagshaw; David D Bowtell; Katie Cockburn; Tony Pawson
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Cell 2013;152(5):1008-20.
2013: Jason J Northey; Tony Pawson; Zhifeng Dong; W Rod Hardy; Andrew Kaplan; Elaine Ngan; Peter M Siegel
Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.
The Journal of biological chemistry 2013;288(7):5210-22.
2013: Hoon-Ki Sung; Kristina Nagy; Seana Mary Lunney Nelson; Jin Gyoon Park; Tony Pawson; Joe Eun Son; S Lee Adamson; Yunui Bae; Soojeong Choi; Rebecca Cowling; Kyung-Oh Doh; Gou Young Koh; Iacovos Michael; Andras Nagy
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis.
Cell metabolism 2013;17(1):61-72.
2012: Josie Ursini-Siegel; C Zhang; Y Zheng; Dongmei Zuo; W Rod Hardy; C Ling; Tony Pawson; L Podmore; William J Muller
The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.
Oncogene 2012;31(48):5038-44.
2012: Jing Jin; Nina Jones; Dontscho Kerjaschki; Chengjin Li; Andras Nagy; Tony Pawson; I George Fantus; Napoleone Ferrara; Hans-Peter Gerber; Marie Jeansson; Masabumi Shibuya; Karen Sison; Hoon-Ki Sung; Ruijun Tian; Monika Tucholska; Monika Wnuk; Cunjie Zhang; Susan E Quaggin
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function.
Cell 2012;151(2):384-99.
2012: Jing Jin; Tony Pawson
Modular evolution of phosphorylation-based signalling systems.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1602):2540-55.
2012: Tony Hunter; Tony Pawson
The evolution of protein phosphorylation. Preface.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1602):2512.
2012: Maria Ana Gomez-Ferreria; Andreas O Helbig; Brett Larsen; Tony Pawson; Mikhail Bashkurov; Anne-Claude Gingras; Laurence Pelletier
Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.
Journal of cell science 2012;125(Pt 16):3745-51.
2012: Manuela O Gustafsson; Alamdar Hussain; Pavel Metalnikov; Abdalla J Mohamed; Dara K Mohammad; Vivian Nguyen; Tony Pawson; C I Edvard Smith; Karen Colwill; Beston F Nore
Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).
Molecular and cellular biology 2012;32(13):2440-53.
2012: Rizaldy P Scott; Julie Ruston; Cord Brakebusch; Jianmei Du; Steve P Hawley; Nina Jones; Tony Pawson
Podocyte-specific loss of Cdc42 leads to congenital nephropathy.
Journal of the American Society of Nephrology : JASN 2012;23(7):1149-54.
2012: Chao Xu; Xiang-Jiao Yang; Linya You; Cheryl H Arrowsmith; Chuanbing Bian; Alexey Bochkarev; Gerald D Gish; Jing Jin; Robert Lam; Jianyun Nie; Tony Pawson; Chris S Tan; Wolfram Tempel; Ruijun Tian; Masoud Vedadi; Gregory A Wasney; Ryan Weist; Jinrong Min
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
Science signaling 2012;5(226):ra39.
2012: Jean-Philippe Lambert; Tony Pawson; Anne-Claude Gingras
Mapping physical interactions within chromatin by proteomic approaches.
Proteomics 2012;12(10):1609-22.
2012: Panagis Filippakopoulos; Anne-Claude Gingras; Tracy Keates; Jean-Philippe Lambert; Maria Mangos; Susanne Müller; Tony Pawson; Sarah Picaud; Rudolf Volkmer; Cheryl H Arrowsmith; Dalia Barsyte-Lovejoy; Ildiko Felletar; Stefan Knapp
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell 2012;149(1):214-31.
2012: Xiaojing Tang; Veronika Csizmok; Julie D Forman-Kay; Tanja Mittag; Stephen Orlicky; Tony Pawson; Frank Sicheri; Mike Tyers
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(9):3287-92.
2012: Nicolas Bisson; Richard J Coward; Jianmei Du; W Rod Hardy; Samer M Hussein; Marie Jeansson; Susan E Quaggin; Julie Ruston; Rachel Vanderlaan; Tony Pawson
The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.
PloS one 2012;7(11):e50996.
2011: Natalia A Kaniuk; Marija Landekic; Michael McClelland; Tobias Meyer; Shuvadeep Mitra; Tony Pawson; Laurence Pelletier; Helene Andrews-Polymenis; Richard D Bagshaw; Malina A Bakowski; Virginie Braun; Veronica Canadien; Sergio Grinstein; Won Do Heo; Ju Huang; John H Brumell
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cellular microbiology 2011;13(11):1812-23.
2011: Florian Grebien; Oliver Hantschel; Ines Kaupe; Akiko Koide; Shohei Koide; Boris Kovacic; Tony Pawson; Hartmut Beug; Sabine Cerny-Reiterer; Gerald D Gish; Peter Valent; John Wojcik; Arkadiusz M Wyrzucki; Giulio Superti-Furga
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
Cell 2011;147(2):306-19.
2011: Chen Chen; Jing Jin; Timothy J Nott; Tony Pawson
Deciphering arginine methylation: Tudor tells the tale.
Nature reviews. Molecular cell biology 2011;12(10):629-42.
2011: Marina Olhovsky; Jin Gyoon Park; Adrian Pasculescu; Tony Pawson; Clark D Wells; Kelly Williton; Anna Yue Dai; Anne-Claude Gingras; Marilyn Goudreault; John Paul Lee; Rune Linding; Karen Colwill
OpenFreezer: a reagent information management software system.
Nature methods 2011;8(8):612-3.
2011: Nicolas Bisson; Ron Bonner; Gordana Ivosev; D Andrew James; Stephen A Tate; Lorne Taylor; Tony Pawson
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.
Nature biotechnology 2011;29(7):653-8.
2011: Rachel D Vanderlaan; W Rod Hardy; M Golam Kabir; Adrian Pasculescu; Nina Jones; Pieter P deTombe; Peter H Backx; Tony Pawson
The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function.
Circulation research 2011;108(2):184-93.
2011: Kelly A Pike; Sarang Kulkarni; Tony Pawson
Immature T-cell clustering and efficient differentiation require the polarity protein Scribble.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(3):1116-21.
2010: Edwige Roy; Dieudonnée Togbe; Amy Holdorf; Dmitry Trubetskoy; Sabrina Nabti; Günter Küblbeck; Sabine Schmitt; Annette Kopp-Schneider; Frank Leithäuser; Peter Möller; Friedhelm Bladt; Günter J Hämmerling; Bernd Arnold; Tony Pawson; Anna Tafuri
Fine tuning of the threshold of T cell selection by the Nck adapters.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7518-26.
2010: Josie Ursini-Siegel; Sean Cory; Dongmei Zuo; William R Hardy; Elton Rexhepaj; Sonya Lam; Babette Schade; Karin Jirstrom; Eva Bjur; Ciriaco A Piccirillo; David Denardo; Lisa M Coussens; Donal J Brennan; William M Gallagher; Morag Park; Tony Pawson; Michael Hallett; William J Muller
Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.
Cancer research 2010;70(20):7776-87.
2010: Guomin Liu; Jianping Zhang; Brett Larsen; Chris Stark; Ashton Breitkreutz; Zhen-Yuan Lin; Bobby-Joe Breitkreutz; Yongmei Ding; Karen Colwill; Adrian Pasculescu; Tony Pawson; Jeffrey L Wrana; Alexey I Nesvizhskii; Brian Raught; Mike Tyers; Anne-Claude Gingras
ProHits: integrated software for mass spectrometry-based interaction proteomics.
Nature biotechnology 2010;28(10):1015-7.
2010: Edwige Roy; Dieudonnée Togbe; Amy D Holdorf; Dmitry Trubetskoy; Sabrina Nabti; Günter Küblbeck; Alexandra Klevenz; Annette Kopp-Schneider; Frank Leithäuser; Peter Möller; Friedhelm Bladt; Günter Hämmerling; Bernd Arnold; Tony Pawson; Anna Tafuri
Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15529-34.
2010: Ashton Breitkreutz; Hyungwon Choi; Jeffrey R Sharom; Lorrie Boucher; Victor Neduva; Brett Larsen; Zhen-Yuan Lin; Bobby-Joe Breitkreutz; Chris Stark; Guomin Liu; Jessica Ahn; Danielle Dewar-Darch; Teresa Reguly; Xiaojing Tang; Ricardo Almeida; Zhaohui Steve Qin; Tony Pawson; Anne-Claude Gingras; Alexey I Nesvizhskii; Mike Tyers
A global protein kinase and phosphatase interaction network in yeast.
Science (New York, N.Y.) 2010;328(5981):1043-6.
2010: Lindsay Richier; Kelly Williton; Leanne Clattenburg; Karen Colwill; Michael O'Brien; Christopher Tsang; Annette Kolar; Natasha Zinck; Pavel Metalnikov; William S Trimble; Stefan R Krueger; Tony Pawson; James P Fawcett
NOS1AP associates with Scribble and regulates dendritic spine development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(13):4796-805.
2010: Matthew J Smith; W Rod Hardy; Guang-Yao Li; Marilyn Goudreault; Steven Hersch; Pavel Metalnikov; Andrei Starostine; Tony Pawson; Mitsuhiko Ikura
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1.
The EMBO journal 2010;29(5):884-96.
2010: Joseph Nachman; Gerald Gish; Cristina Virag; Tony Pawson; Régis Pomès; Emil Pai
Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain.
PloS one 2010;5(6):e11215.
2010: Marcel A T M van Vugt; Alexandra K Gardino; Rune Linding; Gerard J. Ostheimer; H Christian Reinhardt; Shao-En Ong; Chris S Tan; Hua Miao; Susan M Keezer; Jeijin Li; Tony Pawson; Timothy A Lewis; Steven A Carr; Stephen John Smerdon; Thijn R Brummelkamp; Michael B Yaffe
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
PLoS biology 2010;8(1):e1000287.
2009: Claus Jørgensen; Andrew Sherman; Ginny I Chen; Adrian Pasculescu; Alexei Poliakov; Marilyn Hsiung; Brett Larsen; David George Wilkinson; Rune Linding; Tony Pawson
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells.
Science (New York, N.Y.) 2009;326(5959):1502-9.
2009: Chen Chen; Jing Jin; D Andrew James; Melanie A Adams-Cioaba; Jin Gyoon Park; Yahong Guo; Enrico Tenaglia; CHAO XU; Gerald Gish; Jinrong Min; Tony Pawson
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20336-41.
2009: James M Murphy; D Flemming Hansen; Silke Wiesner; D Ranjith Muhandiram; Mikael Borg; Matthew J Smith; Frank Sicheri; Lewis E Kay; Julie D Forman-Kay; Tony Pawson
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
Journal of molecular biology 2009;393(2):409-24.
2009: Chris Soon Heng Tan; Adrian Pasculescu; Wendell A Lim; Tony Pawson; Gary D Bader; Rune Linding
Positive selection of tyrosine loss in metazoan evolution.
Science (New York, N.Y.) 2009;325(5948):1686-8.
2009: Nina Jones; Laura A New; Megan A Fortino; Vera Eremina; Julie Ruston; Ivan M Blasutig; Lamine Aoudjit; Youling Zou; Xiuwen Liu; Guo-Liang Yu; Tomoko Takano; Susan E Quaggin; Tony Pawson
Nck proteins maintain the adult glomerular filtration barrier.
Journal of the American Society of Nephrology : JASN 2009;20(7):1533-43.
2009: S K Y Ho; N Kovacević; R Mark Henkelman; A Boyd; Tony Pawson; Dr. Jeffrey Henderson
EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain.
Neuroscience 2009;160(4):784-95.
2009: Tony Pawson; Lorne Taylor
Protein phosphorylation goes negative.
Molecular cell 2009;34(2):139-40.
2009: Ian W Taylor; Rune Linding; David Warde-Farley; Yongmei Liu; Catia Pesquita; Daniel Faria; Shelley Bull; Tony Pawson; Quaid Morris; Jeffrey L Wrana
Dynamic modularity in protein interaction networks predicts breast cancer outcome.
Nature biotechnology 2009;27(2):199-204.
2009: Lesley T MacNeil; W Rod Hardy; Tony Pawson; Jeffrey L Wrana; Joseph G Culotti
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.
Nature neuroscience 2009;12(2):150-5.
2009: Jing Jin; Xueying Xie; Chen Chen; Jin Gyoon Park; Chris Stark; D Andrew James; Marina Olhovsky; Rune Linding; Yongyi Mao; Tony Pawson
Eukaryotic protein domains as functional units of cellular evolution.
Science signaling 2009;2(98):ra76.
2009: Chris Soon Heng Tan; Bernd Bodenmiller; Adrian Pasculescu; Marko Jovanovic; Michael O Hengartner; Claus Jørgensen; Gary D Bader; Ruedi Aebersold; Tony Pawson; Rune Linding
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.
Science signaling 2009;2(81):ra39.
2008: Aino Ruusala; Tony Pawson; Carl-Henrik Heldin; Pontus Aspenström
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
The Journal of biological chemistry 2008;283(44):30034-44.
2008: Chris Bakal; Rune Linding; Flora Llense; Elleard Heffern; Enrique Martin-Blanco; Tony Pawson; Norbert Perrimon
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.
Science (New York, N.Y.) 2008;322(5900):453-6.
2008: Panagis Filippakopoulos; Michael Kofler; Oliver Hantschel; Gerald D Gish; Florian Grebien; Eidarus Salah; Philipp Neudecker; Lewis E Kay; Benjamin E Turk; Giulio Superti-Furga; Tony Pawson; Stefan Knapp
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Cell 2008;134(5):793-803.
2008: Stephanie Sonnberg; Bruce Seet; Tony Pawson; Stephen B Fleming; Andrew A Mercer
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10955-60.
2008: Andreas Traweger; Giselle Wiggin; Lorne Taylor; Stephen A Tate; Pavel Metalnikov; Tony Pawson
Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10402-7.
2008: Kim Buay Lim; Wenyu Bu; Wah Ing Goh; Esther Koh; Siew Hwa Ong; Tony Pawson; Thankiah Sudhaharan; Sohail Ahmed
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.
The Journal of biological chemistry 2008;283(29):20454-72.
2008: Greg M Findlay; Tony Pawson
How is SOS activated? Let us count the ways.
Nature structural & molecular biology 2008;15(6):538-40.
2008: T Kalle Lundgren; Anna Stenqvist; Rizaldy P Scott; Tony Pawson; Patrik Ernfors
Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors.
Journal of cellular biochemistry 2008;104(3):879-94.
2008: Neil Warner; Leanne E Wybenga-Groot; Tony Pawson
Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.
The FEBS journal 2008;275(10):2561-73.
2008: Ciric To; Sarang Kulkarni; Tony Pawson; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Jeffrey L Wrana; Gianni M Di Guglielmo
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.
The Journal of biological chemistry 2008;283(17):11700-13.
2008: Anna Stenqvist; T Kalle Lundgren; Matthew J Smith; Ola Hermanson; Gonçalo Castelo-Branco; Tony Pawson; Patrik Ernfors
Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok.
Neuroscience letters 2008;435(1):11-6.
2008: Tony Pawson; Rune Linding
Network medicine.
FEBS letters 2008;582(8):1266-70.
2008: Haiming Huang; Lei Li; Chenggang Wu; David Schibli; Karen Colwill; Sucan Ma; Chengjun Li; Protiva Roy; Krystina Ho; Zhou Songyang; Tony Pawson; Youhe Gao; Shawn S-C Li
Defining the specificity space of the human SRC homology 2 domain.
Molecular & cellular proteomics : MCP 2008;7(4):768-84.
2008: Josie Ursini-Siegel; W Rod Hardy; Dongmei Zuo; Sonya H L Lam; Virginie Sanguin-Gendreau; Robert Cardiff; Tony Pawson; William J Muller
ShcA signalling is essential for tumour progression in mouse models of human breast cancer.
The EMBO journal 2008;27(6):910-20.
2008: Ivan M Blasutig; Laura A New; Ajitha Thanabalasuriar; Thamara K Dayarathna; Marilyn Goudreault; Susan E Quaggin; Shawn S-C Li; Samantha Gruenheid; Nina Jones; Tony Pawson
Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.
Molecular and cellular biology 2008;28(6):2035-46.
2008: Martin Lee Miller; Lars Jensen; Francesca Diella; Claus Jørgensen; Michele Tinti; Lei Li; Marilyn Hsiung; Sirlester A Parker; Jennifer Bordeaux; thomas sicheritz-ponten; Marina Olhovsky; Adrian Pasculescu; Jes Alexander; Stefan Knapp; Nikolaj Blom; Peer Bork; Shawn Li; Gianni Cesareni; Tony Pawson; Benjamin E Turk; Michael B Yaffe; Søren Brunak; Rune Linding
Linear motif atlas for phosphorylation-dependent signaling.
Science signaling 2008;1(35):ra2.
2008: George Zogopoulos; Claus Jorgensen; Julinor Bacani; Alexandre Montpetit; Pierre Lepage; Vincent Ferretti; Lauren Chad; Subani Selvarajah; Brent Zanke; Thomas J Hudson; Tony Pawson; Steven Gallinger
Germline EPHB2 receptor variants in familial colorectal cancer.
PloS one 2008;3(8):e2885.
2008: Rune Linding; Lars Jensen; Adrian Pasculescu; Marina Olhovsky; Karen Colwill; Peer Bork; Michael B Yaffe; Tony Pawson
NetworKIN: a resource for exploring cellular phosphorylation networks.
Nucleic acids research 2008;36(Database issue):D695-9.
2007: James P Fawcett; John Georgiou; Julie Ruston; Friedhelm Bladt; Andrew Sherman; Neil Warner; Bechara J Saab; Rizaldy Scott; John C Roder; Tony Pawson
Nck adaptor proteins control the organization of neuronal circuits important for walking.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20973-8.
2007: Jinoh Kim; Ajitha Thanabalasuriar; Tessa Chaworth-Musters; J Christopher Fromme; Elizabeth A Frey; Paula Lario; Pavel Metalnikov; Keyrillos Rizg; Nikhil A Thomas; Sau Fung Lee; Elizabeth L Hartland; Philip R Hardwidge; Tony Pawson; Natalie C J Strynadka; B Brett Finlay; Randy Schekman; Samantha Gruenheid
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function.
Cell host & microbe 2007;2(3):160-71.
2007: James M Murphy; Dmitry M Korzhnev; Derek F J Ceccarelli; Douglas J Briant; Arash Zarrine-Afsar; Frank Sicheri; Lewis E Kay; Tony Pawson
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14336-41.
2007: Caesar S Lim; Bruce Seet; Robert J Ingham; Gerald Gish; Liudmila Matskova; Gösta Winberg; Ingemar Ernberg; Tony Pawson
The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.
Biochemistry 2007;46(35):9874-85.
2007: Liudmila Matskova; C Helmstetter; Robert J Ingham; Gerald Gish; C K Lindholm; Ingemar Ernberg; Tony Pawson; Gösta Winberg
The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein-Barr virus LMP2A membrane protein.
Oncogene 2007;26(34):4908-17.
2007: W Rod Hardy; Lingying Li; Zhi Wang; Jiri Sedy; James Fawcett; Eric Frank; Jan Kucera; Tony Pawson
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis.
Science (New York, N.Y.) 2007;317(5835):251-6.
2007: Nina Jones; W Rod Hardy; Matthew B Friese; Claus Jorgensen; Matthew J Smith; Neil M Woody; Steven J Burden; Tony Pawson
Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Molecular and cellular biology 2007;27(13):4759-73.
2007: Rune Linding; Lars Jensen; Gerard J. Ostheimer; Marcel A T M van Vugt; Claus Jørgensen; Ioana M Miron; Francesca Diella; Karen Colwill; Lorne Taylor; Kelly Elder; Pavel Metalnikov; Vivian Nguyen; Adrian Pasculescu; Jing Jin; Jin Gyoon Park; Leona D Samson; James R Woodgett; Robert B Russell; Peer Bork; Michael B Yaffe; Tony Pawson
Systematic discovery of in vivo phosphorylation networks.
Cell 2007;129(7):1415-26.
2007: Mikael Borg; Tanja Mittag; Tony Pawson; Mike Tyers; Julie D Forman-Kay; Hue Sun Chan
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9650-5.
2007: Derek F J Ceccarelli; Ivan M Blasutig; Marilyn Goudreault; Zhiqin Li; Julie Ruston; Tony Pawson; Frank Sicheri
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9.
The Journal of biological chemistry 2007;282(18):13864-74.
2007: Tony Pawson
Dynamic control of signaling by modular adaptor proteins.
Current opinion in cell biology 2007;19(2):112-6.
2007: Tony Pawson; N Warner
Oncogenic re-wiring of cellular signaling pathways.
Oncogene 2007;26(9):1268-75.
2007: Bruce Seet; Donna M Berry; Jonathan S Maltzman; Jacob Shabason; Monica Raina; Gary A Koretzky; C Jane McGlade; Tony Pawson
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.
The EMBO journal 2007;26(3):678-89.
2006: Matthew J Smith; W Rod Hardy; James M Murphy; Nina Jones; Tony Pawson
Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.
Molecular and cellular biology 2006;26(22):8461-74.
2006: Silke Wiesner; Leanne E Wybenga-Groot; Neil Warner; Hong Lin; Tony Pawson; Julie D Forman-Kay; Frank Sicheri
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases.
The EMBO journal 2006;25(19):4686-96.
2006: Bruce Seet; Ivan Dikic; Ming-Ming Zhou; Tony Pawson
Reading protein modifications with interaction domains.
Nature reviews. Molecular cell biology 2006;7(7):473-83.
2006: Clark D Wells; James P Fawcett; Andreas Traweger; Yojiro Yamanaka; Marilyn Goudreault; Kelly Elder; Sarang Kulkarni; Gerald Gish; Cristina Virag; Caesar Lim; Karen Colwill; Andrei Starostine; Pavel Metalnikov; Tony Pawson
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
Cell 2006;125(3):535-48.
2006: Claire Chazaud; Yojiro Yamanaka; Tony Pawson; Janet Rossant
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.
Developmental cell 2006;10(5):615-24.
2006: Nina Jones; Ivan M Blasutig; Vera Eremina; Julie Ruston; Friedhelm Bladt; Hongping Li; Haiming Huang; Louise Larose; Shawn S-C Li; Tomoko Takano; Susan E Quaggin; Tony Pawson
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.
Nature 2006;440(7085):818-23.
2006: Jamie J Kwan; Neil Warner; Joban Maini; Kelvin W Chan Tung; Hoshang Zakaria; Tony Pawson; Logan W Donaldson
Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction.
Journal of molecular biology 2006;356(1):142-54.
2006: Karen Colwill; Clark D Wells; Kelly Elder; Marilyn Goudreault; Kadija Hersi; Sarang Kulkarni; W Rod Hardy; Tony Pawson; Gregg B Morin
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites.
BMC biotechnology 2006;6():13.
2005: Sigal Gelkop; Gerrald D Gish; Yael Babichev; Tony Pawson; Noah Isakov
T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8123-32.
2005: Robert J Ingham; Judith Raaijmakers; Caesar S H Lim; Geraldine Mbamalu; Gerald Gish; Fu Chen; Liudmila Matskova; Ingemar Ernberg; Gösta Winberg; Tony Pawson
The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor.
The Journal of biological chemistry 2005;280(40):34133-42.
2005: Robert Steven; Lijia Zhang; Joseph G Culotti; Tony Pawson
The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.
Genes & development 2005;19(17):2016-29.
2005: Robert J Ingham; Karen Colwill; Caley Howard; Sabine Dettwiler; Caesar S H Lim; Joanna Yu; Kadija Hersi; Judith Raaijmakers; Gerald Gish; Geraldine Mbamalu; Lorne Taylor; Benny Yeung; Galina Vassilovski; Manish Amin; Fu Chen; Liudmila Matskova; Gösta Winberg; Ingemar Ernberg; Rune Linding; Paul O'Donnell; Andrei Starostine; Walter Keller; Pavel Metalnikov; Chris Stark; Tony Pawson
WW domains provide a platform for the assembly of multiprotein networks.
Molecular and cellular biology 2005;25(16):7092-106.
2005: Giselle R Wiggin; James P Fawcett; Tony Pawson
Polarity proteins in axon specification and synaptogenesis.
Developmental cell 2005;8(6):803-16.
2005: Tony Pawson; Rune Linding
Synthetic modular systems--reverse engineering of signal transduction.
FEBS letters 2005;579(8):1808-14.
2004: Matthew J Smith; Sarang Kulkarni; Tony Pawson
FF domains of CA150 bind transcription and splicing factors through multiple weak interactions.
Molecular and cellular biology 2004;24(21):9274-85.
2004: Megan Cully; Andrew Elia; Siew-Hwa Ong; Vuk Stambolic; Tony Pawson; Ming Tsao; Tak W Mak
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15358-63.
2004: Jamie J Kwan; Neil Warner; Tony Pawson; Logan W Donaldson
The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50.
Journal of molecular biology 2004;342(2):681-93.
2004: Bruce Seet; Tony Pawson
MAPK signaling: Sho business.
Current biology : CB 2004;14(17):R708-10.
2004: Jing Jin; F Smith; Chris Stark; Clark D Wells; James P Fawcett; Sarang Kulkarni; Pavel Metalnikov; Paul O'Donnell; Paul Taylor; Lorne Taylor; Alexandre Zougman; James R Woodgett; Lorene K Langeberg; John D Scott; Tony Pawson
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Current biology : CB 2004;14(16):1436-50.
2004: Pamela J Woodring; Jill Meisenhelder; Sam A Johnson; Guo-Lei Zhou; Jeffrey Field; Kavita Shah; Friedhelm Bladt; Tony Pawson; Masaru Niki; Pier Paolo Pandolfi; Jean Y J Wang; Tony Hunter
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading.
The Journal of cell biology 2004;165(4):493-503.
2004: Yuki Kimura; Nina Jones; Michael Klüppel; Masanori Hirashima; Kazunobu Tachibana; Jason B Cohn; Jeffrey L Wrana; Tony Pawson; alan bernstein
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6015-20.
2004: Robert J Ingham; Gerald Gish; Tony Pawson
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.
Oncogene 2004;23(11):1972-84.
2004: Wanyin Deng; José Luis Puente; Samantha Gruenheid; Yuling Li; Bruce A Vallance; Alejandra Vázquez; Jeannette Barba; J Antonio Ibarra; Paul O'Donnell; Pavel Metalnikov; Keith Ashman; Sansan Lee; David Goode; Tony Pawson; B Brett Finlay
Dissecting virulence: systematic and functional analyses of a pathogenicity island.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3597-602.
2004: Samantha Gruenheid; Inna Sekirov; Nikhil A Thomas; Wanyin Deng; Paul O'Donnell; David Goode; Yuling Li; Elizabeth A Frey; Nat F Brown; Pavel Metalnikov; Tony Pawson; Keith Ashman; B Brett Finlay
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7.
Molecular microbiology 2004;51(5):1233-49.
2004: Caroline Saucier; Hanane Khoury; Ka-Man Venus Lai; Pascal Peschard; David Dankort; Monica A Naujokas; Jocelyn Holash; George D Yancopoulos; William J Muller; Tony Pawson; Morag Park
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2345-50.
2004: Tony Pawson
Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.
Cell 2004;116(2):191-203.
2003: Terrance J Kubiseski; Joseph G Culotti; Tony Pawson
Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo.
Molecular and cellular biology 2003;23(19):6823-35.
2003: Perry L Howard; Marie C Chia; Suzanne Del Rizzo; Fei-Fei Liu; Tony Pawson
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11267-72.
2003: Tak W Mak; Arda Shahinian; Steven K Yoshinaga; Andrew Wakeham; Lorrie Boucher; Melania Pintilie; Gordon Duncan; Beata U Gajewska; Matthew A Gronski; Urs Eriksson; Bernhard Odermatt; Alexandra Ho; Denis Bouchard; John S Whorisky; Manel Jordana; Pamela S Ohashi; Tony Pawson; Friedhelm Bladt; Anna Tafuri
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
Nature immunology 2003;4(8):765-72.
2003: Friedhelm Bladt; Elke Aippersbach; Sigal Gelkop; Geraldine A Strasser; Piers Nash; Anna Tafuri; Frank B Gertler; Tony Pawson
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.
Molecular and cellular biology 2003;23(13):4586-97.
2003: Tony Pawson
Organization of cell-regulatory systems through modular-protein-interaction domains.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1251-62.
2003: Tilo Kunath; Gerald Gish; Heiko Lickert; Nina Jones; Tony Pawson; Janet Rossant
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.
Nature biotechnology 2003;21(5):559-61.
2003: Tony Pawson; Piers Nash
Assembly of cell regulatory systems through protein interaction domains.
Science (New York, N.Y.) 2003;300(5618):445-52.
2003: Pamela J Plant; James P Fawcett; Dan C C Lin; Amy D Holdorf; Kathleen Binns; Sarang Kulkarni; Tony Pawson
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.
Nature cell biology 2003;5(4):301-8.
2003: Ian Donaldson; Joel Martin; Berry de Bruijn; Cheryl Wolting; Vicki Lay; Brigitte Tuekam; Shudong Zhang; Berivan Baskin; Gary Bader; Katerina Michalickova; Tony Pawson; Christopher W V Hogue
PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine.
BMC bioinformatics 2003;4():11.
2003: Jiefei Tong; Sabine Elowe; Piers Nash; Tony Pawson
Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity.
The Journal of biological chemistry 2003;278(8):6111-9.
2003: Qin Liu; Donna Berry; Piers Nash; Tony Pawson; C Jane McGlade; Shawn S-C Li
Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition.
Molecular cell 2003;11(2):471-81.
2002: Marie Killeen; Jeifei Tong; Aldis Krizus; Robert Steven; Ian Scott; Tony Pawson; Joseph G Culotti
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.
Developmental biology 2002;251(2):348-66.
2002: Logan W Donaldson; Gerald Gish; Tony Pawson; Lewis E Kay; Julie D Forman-Kay
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14053-8.
2002: Tony Pawson
Regulation and targets of receptor tyrosine kinases.
European journal of cancer (Oxford, England : 1990) 2002;38 Suppl 5():S3-10.
2002: Donna M Berry; Piers Nash; Stanley K-W Liu; Tony Pawson; C Jane McGlade
A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.
Current biology : CB 2002;12(15):1336-41.
2002: Laura Velazquez; Alec M Cheng; Heather E Fleming; Caren Furlonger; Shirly Vesely; alan bernstein; Christopher J Paige; Tony Pawson
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.
The Journal of experimental medicine 2002;195(12):1599-611.
2002: Friedhelm Bladt; Anna Tafuri; Sigal Gelkop; Lowell Langille; Tony Pawson
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6816-21.
2002: Tony Pawson; Monica Raina; Piers Nash
Interaction domains: from simple binding events to complex cellular behavior.
FEBS letters 2002;513(1):2-10.
2002: Peter M Hwang; Chengjun Li; Massimo Morra; Jennifer Lillywhite; D Ranjith Muhandiram; Frank Gertler; Cox Terhorst; Lewis E Kay; Tony Pawson; Julie D Forman-Kay; Shun-Cheng Li
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
The EMBO journal 2002;21(3):314-23.
2001: Dr. Jeffrey Henderson; John Georgiou; Z Jia; J Robertson; Sabine Elowe; John C Roder; Tony Pawson
The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function.
Neuron 2001;32(6):1041-56.
2001: Tony Pawson; Gerald Gish; P Nash
SH2 domains, interaction modules and cellular wiring.
Trends in cell biology 2001;11(12):504-11.
2001: P Nash; Xiaojing Tang; Stephen Orlicky; Q Chen; Frank B Gertler; M D Mendenhall; Frank Sicheri; Tony Pawson; Mike Tyers
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
Nature 2001;414(6863):514-21.
2001: SH Ong; S Dilworth; I Hauck-Schmalenberger; Tony Pawson; F Kiefer
ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
The EMBO journal 2001;20(22):6327-36.
2001: J Tong; Marie Killeen; Robert Steven; Kathleen Binns; Joseph G Culotti; Tony Pawson
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.
The Journal of biological chemistry 2001;276(44):40917-25.
2001: Liudmila Matskova; Ingemar Ernberg; Tony Pawson; Gösta Winberg
C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal.
Journal of virology 2001;75(22):10941-9.
2001: Sabine Elowe; SJ Holland; Sarang Kulkarni; Tony Pawson
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.
Molecular and cellular biology 2001;21(21):7429-41.
2001: Leanne E Wybenga-Groot; B Baskin; SH Ong; J Tong; Tony Pawson; Frank Sicheri
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
Cell 2001;106(6):745-57.
2001: Samantha Gruenheid; R DeVinney; Friedhelm Bladt; Danika L Goosney; Sigal Gelkop; G D Gish; Tony Pawson; B Brett Finlay
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells.
Nature cell biology 2001;3(9):856-9.
2001: TM Saxton; Alec M Cheng; SH Ong; Y Lu; R Sakai; James C Cross; Tony Pawson
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.
Current biology : CB 2001;11(9):662-70.
2001: Wolfgang F Vogel; A Aszódi; Frauke Alves; Tony Pawson
Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development.
Molecular and cellular biology 2001;21(8):2906-17.
2001: Anna Tafuri; Arda Shahinian; Friedhelm Bladt; Steven K Yoshinaga; Manel Jordana; Andrew Wakeham; Lorrie Boucher; Denis Bouchard; Vera S F Chan; Gordon Duncan; Bernhard Odermatt; Alexandra Ho; Annick Itie; Tom Horan; John S Whoriskey; Tony Pawson; Josef M Penninger; Pamela S Ohashi; Tak W Mak
ICOS is essential for effective T-helper-cell responses.
Nature 2001;409(6816):105-9.
2001: Gary Bader; I Donaldson; Cheryl Wolting; B F Ouellette; Tony Pawson; Christopher W V Hogue
BIND--The Biomolecular Interaction Network Database.
Nucleic acids research 2001;29(1):242-5.
2000: R Sakai; Dr. Jeffrey Henderson; John P O'Bryan; Andrew Elia; TM Saxton; Tony Pawson
The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.
Neuron 2000;28(3):819-33.
2000: Gösta Winberg; Liudmila Matskova; Fu Chen; PJ Plant; Daniela Rotin; Gerald Gish; Robert J Ingham; Ingemar Ernberg; Tony Pawson
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.
Molecular and cellular biology 2000;20(22):8526-35.
2000: J Fawcett; Tony Pawson
Signal transduction. N-WASP regulation--the sting in the tail.
Science (New York, N.Y.) 2000;290(5492):725-6.
2000: D Lin; A S Edwards; James P Fawcett; Geraldine Mbamalu; John D Scott; Tony Pawson
A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity.
Nature cell biology 2000;2(8):540-7.
2000: L Velazquez; Gerald Gish; P van der Geer; Lorne Taylor; J Shulman; Tony Pawson
The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.
Blood 2000;96(1):132-8.
2000: Kathleen Binns; P P Taylor; Frank Sicheri; Tony Pawson; SJ Holland
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.
Molecular and cellular biology 2000;20(13):4791-805.
2000: Greg J Bashaw; T Kidd; D Murray; Tony Pawson; Corey S Goodman
Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.
Cell 2000;101(7):703-15.
2000: Matthew S Kimber; J Nachman; A M Cunningham; Gerald Gish; Tony Pawson; Emil F Pai
Structural basis for specificity switching of the Src SH2 domain.
Molecular cell 2000;5(6):1043-9.
2000: Ka-Man Venus Lai; Tony Pawson
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo.
Genes & development 2000;14(9):1132-45.
2000: Tony Pawson; P Nash
Protein-protein interactions define specificity in signal transduction.
Genes & development 2000;14(9):1027-47.
2000: S V Kulkarni; Gerald Gish; P van der Geer; Mark Henkemeyer; Tony Pawson
Role of p120 Ras-GAP in directed cell movement.
The Journal of cell biology 2000;149(2):457-70.
2000: Catherine Zwahlen; SC Li; Lewis E Kay; Tony Pawson; Julie D Forman-Kay
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.
The EMBO journal 2000;19(7):1505-15.
2000: TM Saxton; BG Ciruna; Doug Holmyard; Sarang Kulkarni; K Harpal; Janet Rossant; Tony Pawson
The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.
Nature genetics 2000;24(4):420-3.
2000: W Vogel; C Brakebusch; R Fässler; Frauke Alves; F Ruggiero; Tony Pawson
Discoidin domain receptor 1 is activated independently of beta(1) integrin.
The Journal of biological chemistry 2000;275(8):5779-84.
1999: S C Li; Gerald Gish; D Yang; A J Coffey; Julie D Forman-Kay; Ingemar Ernberg; Lewis E Kay; Tony Pawson
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.
Current biology : CB 1999;9(23):1355-62.
1999: X Wang; Peter J Roy; SJ Holland; L W Zhang; Joseph G Culotti; Tony Pawson
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor.
Molecular cell 1999;4(6):903-13.
1999: Julie D Forman-Kay; Tony Pawson
Diversity in protein recognition by PTB domains.
Current opinion in structural biology 1999;9(6):690-5.
1999: M J Rauh; V Blackmore; Eran R Andrechek; CG Tortorice; R Daly; V K Lai; Tony Pawson; Robert Cardiff; Peter M Siegel; William J Muller
Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.
Molecular and cellular biology 1999;19(12):8169-79.
1999: Tony Pawson; TM Saxton
Signaling networks--do all roads lead to the same genes?
Cell 1999;97(6):675-8.
1999: TM Saxton; Tony Pawson
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3790-5.
1999: D Lin; Gerald Gish; Zhou Songyang; Tony Pawson
The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.
The Journal of biological chemistry 1999;274(6):3726-33.
1999: D Stapleton; I Balan; Tony Pawson; Frank Sicheri
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
Nature structural biology 1999;6(1):44-9.
1998: Alec M Cheng; TM Saxton; R Sakai; Sarang Kulkarni; Geraldine Mbamalu; W Vogel; CG Tortorice; Robert Cardiff; James C Cross; William J Muller; Tony Pawson
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
Cell 1998;95(6):793-803.
1998: SC Li; Catherine Zwahlen; Sébastien J F Vincent; C J McGlade; Lewis E Kay; Tony Pawson; Julie D Forman-Kay
Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.
Nature structural biology 1998;5(12):1075-83.
1998: J Oldenhof; RG Vickery; M Anafi; James N Oak; A Ray; O Schoots; Tony Pawson; M von Zastrow; Hubert H M Van Tol
SH3 binding domains in the dopamine D4 receptor.
Biochemistry 1998;37(45):15726-36.
1998: F Kiefer; John H Brumell; N Al-Alawi; Sylvain Latour; A Cheng; André Veillette; S Grinstein; Tony Pawson
The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils.
Molecular and cellular biology 1998;18(7):4209-20.
1998: Robert Steven; T J Kubiseski; H Zheng; S Kulkarni; J Mancillas; A Ruiz Morales; C W Hogue; Tony Pawson; Joseph G Culotti
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.
Cell 1998;92(6):785-95.
1998: SJ Holland; Elior Peles; Tony Pawson; J Schlessinger
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.
Current opinion in neurobiology 1998;8(1):117-27.
1997: Tony Pawson; John D Scott
Signaling through scaffold, anchoring, and adaptor proteins.
Science (New York, N.Y.) 1997;278(5346):2075-80.
1997: W Vogel; Gerald Gish; Frauke Alves; Tony Pawson
The discoidin domain receptor tyrosine kinases are activated by collagen.
Molecular cell 1997;1(1):13-23.
1997: M Anafi; F Kiefer; Gerald Gish; Geraldine Mbamalu; Norman N Iscove; Tony Pawson
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
The Journal of biological chemistry 1997;272(44):27804-11.
1997: Alec M Cheng; I Negishi; S J Anderson; A C Chan; J Bolen; D Y Loh; Tony Pawson
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9797-801.
1997: SC Li; Zhou Songyang; Sébastien J F Vincent; Catherine Zwahlen; S Wiley; L Cantley; Lewis E Kay; Julie D Forman-Kay; Tony Pawson
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7204-9.
1997: SJ Holland; nicholas gale; Gerald Gish; R A Roth; Zhou Songyang; L C Cantley; Mark Henkemeyer; George D Yancopoulos; Tony Pawson
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.
The EMBO journal 1997;16(13):3877-88.
1997: TM Saxton; Mark Henkemeyer; S Gasca; R Shen; Derrick J Rossi; F Shalaby; G S Feng; Tony Pawson
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.
The EMBO journal 1997;16(9):2352-64.
1997: P van der Geer; Mark Henkemeyer; T Jacks; Tony Pawson
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.
Molecular and cellular biology 1997;17(4):1840-7.
1997: T J Kubiseski; YuhMin Chook; W E Parris; M Rozakis-Adcock; Tony Pawson
High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate.
The Journal of biological chemistry 1997;272(3):1799-804.
1996: F Kiefer; LA Tibbles; M Anafi; A Janssen; Brent Zanke; Norman Lassam; Tony Pawson; James R Woodgett; Norman N Iscove
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
The EMBO journal 1996;15(24):7013-25.
1996: S C Li; K M Lai; Gerald Gish; W E Parris; P van der Geer; Julie D Forman-Kay; Tony Pawson
Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein.
The Journal of biological chemistry 1996;271(50):31855-62.
1996: X Piao; R Paulson; P van der Geer; Tony Pawson; alan bernstein
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14665-9.
1996: YuhMin Chook; Gerald Gish; C M Kay; Emil F Pai; Tony Pawson
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.
The Journal of biological chemistry 1996;271(48):30472-8.
1996: M K Rosen; KH Gardner; R C Willis; W E Parris; Tony Pawson; Lewis E Kay
Selective methyl group protonation of perdeuterated proteins.
Journal of molecular biology 1996;263(5):627-36.
1996: D Orioli; Mark Henkemeyer; Greg Lemke; Rudiger Klein; Tony Pawson
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.
The EMBO journal 1996;15(22):6035-49.
1996: P van der Geer; S Wiley; Gerald Gish; Tony Pawson
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
Current biology : CB 1996;6(11):1435-44.
1996: SJ Holland; nicholas gale; Geraldine Mbamalu; George D Yancopoulos; Mark Henkemeyer; Tony Pawson
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands.
Nature 1996;383(6602):722-5.
1996: Karen Colwill; L L Feng; J M Yeakley; Gerald Gish; J F Cáceres; Tony Pawson; Xiang-Dong Fu
SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.
The Journal of biological chemistry 1996;271(40):24569-75.
1996: S Roche; J McGlade; M Jones; Gerald Gish; Tony Pawson; Sara A Courtneidge
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.
The EMBO journal 1996;15(18):4940-8.
1996: C A Mallick-Wood; W Pao; Alec M Cheng; J M Lewis; S Kulkarni; J B Bolen; B Rowley; R E Tigelaar; Tony Pawson; Adrian C Hayday
Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9704-9.
1996: M Anafi; M K Rosen; Gerald Gish; Lewis E Kay; Tony Pawson
A potential SH3 domain-binding site in the Crk SH2 domain.
The Journal of biological chemistry 1996;271(35):21365-74.
1996: Mark Henkemeyer; D Orioli; Dr. Jeffrey Henderson; TM Saxton; J Roder; Tony Pawson; Rudiger Klein
Nuk controls pathfinding of commissural axons in the mammalian central nervous system.
Cell 1996;86(1):35-46.
1996: nicholas gale; SJ Holland; David M Valenzuela; A Flenniken; L Pan; Terence Edward Ryan; Mark Henkemeyer; K Strebhardt; H Hirai; David George Wilkinson; Tony Pawson; Samuel Davis; George D Yancopoulos
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.
Neuron 1996;17(1):9-19.
1996: P van der Geer; S Wiley; Gerald Gish; V K Lai; R Stephens; M F White; D Kaplan; Tony Pawson
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):963-8.
1996: Abhijit Guha; Nelson Lau; I Huvar; David H Gutmann; J Provias; Tony Pawson; Gerry R Boss
Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.
Oncogene 1996;12(3):507-13.
1996: Karen Colwill; Tony Pawson; Brenda Andrews; J Prasad; James L Manley; John C Bell; Peter Duncan
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
The EMBO journal 1996;15(2):265-75.
1995: Alec M Cheng; B Rowley; W Pao; Adrian C Hayday; J B Bolen; Tony Pawson
Syk tyrosine kinase required for mouse viability and B-cell development.
Nature 1995;378(6554):303-6.
1995: Zhou Songyang; Gerald Gish; Geraldine Mbamalu; Tony Pawson; Lewis C Cantley
A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
The Journal of biological chemistry 1995;270(44):26029-32.
1995: Mark Henkemeyer; David J Rossi; D P Holmyard; M C Puri; Geraldine Mbamalu; K Harpal; T S Shih; T Jacks; Tony Pawson
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.
Nature 1995;377(6551):695-701.
1995: M Rozakis-Adcock; P van der Geer; Geraldine Mbamalu; Tony Pawson
MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.
Oncogene 1995;11(7):1417-26.
1995: K M Lai; Jean Paul olivier; Gerald Gish; Mark Henkemeyer; J McGlade; Tony Pawson
A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.
Molecular and cellular biology 1995;15(9):4810-8.
1995: P van der Geer; Tony Pawson
The PTB domain: a new protein module implicated in signal transduction.
Trends in biochemical sciences 1995;20(7):277-80.
1995: Thomas Raabe; Jean Paul olivier; Barry J Dickson; Xiangdong Liu; Gerald Gish; Tony Pawson; Ernst Hafen
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.
The EMBO journal 1995;14(11):2509-18.
1995: P van der Geer; S Wiley; V K Lai; Jean Paul olivier; Gerald Gish; R Stephens; D Kaplan; S Shoelson; Tony Pawson
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides.
Current biology : CB 1995;5(4):404-12.
1995: M K Rosen; T Yamazaki; Gerald Gish; C M Kay; Tony Pawson; Lewis E Kay
Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein.
Nature 1995;374(6521):477-9.
1995: Luisa Lanfrancone; Giuliana Pelicci; Maria Felice Brizzi; M G Aronica; C Casciari; S Giuli; Luigi Pegoraro; Tony Pawson; Pier Giuseppe Pelicci; M G Arouica
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.
Oncogene 1995;10(5):907-17.
1995: Louise Larose; Gerald Gish; Tony Pawson
Construction of an SH2 domain-binding site with mixed specificity.
The Journal of biological chemistry 1995;270(8):3858-62.
1995: Tony Pawson
Protein modules and signalling networks.
Nature 1995;373(6515):573-80.
1995: Gerald Gish; Louise Larose; R Shen; Tony Pawson
Biochemical analysis of SH2 domain-mediated protein interactions.
Methods in enzymology 1995;254():503-23.
1994: Tetsuzo Tauchi; Gen-Sheng Feng; Mark S Marshall; R Shen; Charlie Mantel; Tony Pawson; Hal E Broxmeyer
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
The Journal of biological chemistry 1994;269(40):25206-11.
1994: Anna Elisabetta Salcini; J McGlade; Giuliana Pelicci; Ildo Nicoletti; Tony Pawson; Pier Giuseppe Pelicci
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.
Oncogene 1994;9(10):2827-36.
1994: L E Marengere; Zhou Songyang; Gerald Gish; Michael D Schaller; Thomas J Parsons; Michael J Stern; L C Cantley; Tony Pawson
SH2 domain specificity and activity modified by a single residue.
Nature 1994;369(6480):502-5.
1994: Gen-Sheng Feng; R Shen; Hong-Qiang Heng; Lap-Chee Tsui; Andrius Kazlauskas; Tony Pawson
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp.
Oncogene 1994;9(6):1545-50.
1994: Tetsuzo Tauchi; Gen-Sheng Feng; R Shen; H Y Song; David B Donner; Tony Pawson; Hal E Broxmeyer
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.
The Journal of biological chemistry 1994;269(21):15381-7.
1994: NA Farrow; R Muhandiram; A U Singer; S M Pascal; C M Kay; Gerald Gish; S E Shoelson; Tony Pawson; Julie D Forman-Kay; Lewis E Kay
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation.
Biochemistry 1994;33(19):5984-6003.
1994: S M Pascal; A U Singer; Gerald Gish; T Yamazaki; S E Shoelson; Tony Pawson; Lewis E Kay; Julie D Forman-Kay
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell 1994;77(3):461-72.
1994: Mark Henkemeyer; L E Marengere; J McGlade; Jean Paul olivier; Ronald A Conlon; D P Holmyard; K Letwin; Tony Pawson
Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.
Oncogene 1994;9(4):1001-14.
1994: Zhou Songyang; Steven E Shoelson; J McGlade; P Olivier; Tony Pawson; X R Bustelo; M Barbacid; H Sabe; H Hanafusa; T Yi
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Molecular and cellular biology 1994;14(4):2777-85.
1994: L Puil; J Liu; Gerald Gish; Geraldine Mbamalu; D Bowtell; Pier Giuseppe Pelicci; R Arlinghaus; Tony Pawson
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
The EMBO journal 1994;13(4):764-73.
1994: Tony Pawson
Tyrosine kinase signalling pathways.
Princess Takamatsu symposia 1994;24():303-22.
1994: L E Marengere; Tony Pawson
Structure and function of SH2 domains.
Journal of cell science. Supplement 1994;18():97-104.
1994: Tony Pawson
SH2 and SH3 domains in signal transduction.
Advances in cancer research 1994;64():87-110.
1994: X Liu; Tony Pawson
Biochemistry of the Src protein-tyrosine kinase: regulation by SH2 and SH3 domains.
Recent progress in hormone research 1994;49():149-60.
1993: M Kozlowski; I Mlinaric-Rascan; Gen-Sheng Feng; R Shen; Tony Pawson; Katherine A Siminovitch
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.
The Journal of experimental medicine 1993;178(6):2157-63.
1993: V Lhoták; Tony Pawson
Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.
Molecular and cellular biology 1993;13(11):7071-9.
1993: Michael J Stern; L E Marengere; R J Daly; E J Lowenstein; M Kokel; A Batzer; P Olivier; Tony Pawson; Joseph Schlessinger
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
Molecular biology of the cell 1993;4(11):1175-88.
1993: Louise Larose; Gerald Gish; S Shoelson; Tony Pawson
Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.
Oncogene 1993;8(9):2493-9.
1993: X Liu; L E Marengere; C A Koch; Tony Pawson
The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.
Molecular and cellular biology 1993;13(9):5225-32.
1993: J McGlade; B Brunkhorst; D Anderson; Geraldine Mbamalu; J Settleman; S Dedhar; M Rozakis-Adcock; Lan Bo Chen; Tony Pawson
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.
The EMBO journal 1993;12(8):3073-81.
1993: O Segatto; Giuliana Pelicci; S Giuli; G Digiesi; Pier Paolo Di Fiore; J McGlade; Tony Pawson; Pier Giuseppe Pelicci
Shc products are substrates of erbB-2 kinase.
Oncogene 1993;8(8):2105-12.
1993: Tony Pawson; J Schlessingert
SH2 and SH3 domains.
Current biology : CB 1993;3(7):434-42.
1993: Tony Pawson; P Olivier; M Rozakis-Adcock; J McGlade; Mark Henkemeyer
Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):279-85.
1993: G Payne; Steven E Shoelson; G D Gish; Tony Pawson; Christopher T Walsh
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4902-6.
1993: M Rozakis-Adcock; R Fernley; J Wade; Tony Pawson; D Bowtell
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
Nature 1993;363(6424):83-5.
1993: X Liu; Scott Brodeur; Gerald Gish; Zhou Songyang; L C Cantley; A P Laudano; Tony Pawson
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.
Oncogene 1993;8(5):1119-26.
1993: Jean Paul olivier; Thomas Raabe; Mark Henkemeyer; Barry J Dickson; Geraldine Mbamalu; Benjamin L Margolis; J Schlessinger; Ernst Hafen; Tony Pawson
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
Cell 1993;73(1):179-91.
1993: G J Pronk; J McGlade; Giuliana Pelicci; Tony Pawson; Johannes L Bos
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
The Journal of biological chemistry 1993;268(8):5748-53.
1993: Gen-Sheng Feng; C C Hui; Tony Pawson
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.
Science (New York, N.Y.) 1993;259(5101):1607-11.
1993: A D Reith; C Ellis; N Maroc; Tony Pawson; alan bernstein; Patrice Dubreuil
'W' mutant forms of the Fms receptor tyrosine kinase act in a dominant manner to suppress CSF-1 dependent cellular transformation.
Oncogene 1993;8(1):45-53.
1992: L E Marengere; Tony Pawson
Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62.
The Journal of biological chemistry 1992;267(32):22779-86.
1992: Tony Pawson; Gerald Gish
SH2 and SH3 domains: from structure to function.
Cell 1992;71(3):359-62.
1992: K A Meckling-Gill; S P Yee; J W Schrader; Tony Pawson
A retrovirus encoding the v-fps protein-tyrosine kinase induces factor-independent growth and tumorigenicity in FDC-P1 cells.
Biochimica et biophysica acta 1992;1137(1):65-72.
1992: J McGlade; A Cheng; Giuliana Pelicci; Pier Giuseppe Pelicci; Tony Pawson
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8869-73.
1992: K Letwin; L Mizzen; B Motro; Y Ben-David; alan bernstein; Tony Pawson
A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.
The EMBO journal 1992;11(10):3521-31.
1992: Giuliana Pelicci; Luisa Lanfrancone; F Grignani; J McGlade; F Cavallo; G Forni; Ildo Nicoletti; Francesco Grignani; Tony Pawson; Pier Giuseppe Pelicci
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Cell 1992;70(1):93-104.
1992: E M Douville; Daniel E H Afar; B W Howell; K Letwin; L Tannock; Y Ben-David; Tony Pawson; John C Bell
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.
Molecular and cellular biology 1992;12(6):2681-9.
1992: L Puil; Tony Pawson
Vagaries of vav.
Current biology : CB 1992;2(5):275-7.
1992: M Reedijk; X Liu; P van der Geer; K Letwin; M D Waterfield; Tony Hunter; Tony Pawson
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.
The EMBO journal 1992;11(4):1365-72.
1992: C A Koch; Michael F Moran; D Anderson; X Q Liu; Geraldine Mbamalu; Tony Pawson
Multiple SH2-mediated interactions in v-src-transformed cells.
Molecular and cellular biology 1992;12(3):1366-74.
1991: A D Reith; C Ellis; S D Lyman; D M Anderson; D E Williams; alan bernstein; Tony Pawson
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.
The EMBO journal 1991;10(9):2451-9.
1991: C Ellis; X Q Liu; D Anderson; N Abraham; André Veillette; Tony Pawson
Tyrosine phosphorylation of GAP and GAP-associated proteins in lymphoid and fibroblast cells expressing lck.
Oncogene 1991;6(6):895-901.
1991: R Rottapel; M Reedijk; D E Williams; S D Lyman; D M Anderson; Tony Pawson; alan bernstein
The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.
Molecular and cellular biology 1991;11(6):3043-51.
1991: C A Koch; D Anderson; Michael F Moran; C Ellis; Tony Pawson
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
Science (New York, N.Y.) 1991;252(5006):668-74.
1991: V Lhoták; P Greer; K Letwin; Tony Pawson
Characterization of elk, a brain-specific receptor tyrosine kinase.
Molecular and cellular biology 1991;11(5):2496-502.
1991: X Q Liu; Tony Pawson
The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains.
Molecular and cellular biology 1991;11(5):2511-6.
1991: Michael F Moran; Paul Polakis; F McCormick; Tony Pawson; C Ellis
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
Molecular and cellular biology 1991;11(4):1804-12.
1991: Y Ben-David; K Letwin; L Tannock; alan bernstein; Tony Pawson
A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.
The EMBO journal 1991;10(2):317-25.
1990: D Anderson; C A Koch; L Grey; C Ellis; Michael F Moran; Tony Pawson
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors.
Science (New York, N.Y.) 1990;250(4983):979-82.
1990: Michael F Moran; C A Koch; D Anderson; C Ellis; L England; G Steven Martin; Tony Pawson
Src homology region 2 domains direct protein-protein interactions in signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8622-6.
1990: M Reedijk; X Q Liu; Tony Pawson
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
Molecular and cellular biology 1990;10(11):5601-8.
1990: P Greer; V Maltby; Janet Rossant; alan bernstein; Tony Pawson
Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice.
Molecular and cellular biology 1990;10(6):2521-7.
1990: Y Wildenhain; Tony Pawson; Martin E Blackstein; Irene L Andrulis
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.
Oncogene 1990;5(6):879-83.
1990: C Ellis; M Moran; F McCormick; Tony Pawson
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases.
Nature 1990;343(6256):377-81.
1989: Tony Pawson; K Letwin; T Lee; Q L Hao; N Heisterkamp; J Groffen
The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family.
Molecular and cellular biology 1989;9(12):5722-5.
1989: S P Yee; D Mock; P Greer; V Maltby; Janet Rossant; alan bernstein; Tony Pawson
Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase.
Molecular and cellular biology 1989;9(12):5491-9.
1989: C A Koch; M Moran; I Sadowski; Tony Pawson
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
Molecular and cellular biology 1989;9(10):4131-40.
1989: A Lavigueur; V Maltby; D Mock; Janet Rossant; Tony Pawson; alan bernstein
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.
Molecular and cellular biology 1989;9(9):3982-91.
1989: S P Yee; D Mock; V Maltby; M Silver; Janet Rossant; alan bernstein; Tony Pawson
Cardiac and neurological abnormalities in v-fps transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5873-7.
1989: G R Taylor; M Reedijk; V Rothwell; Larry R Rohrschneider; Tony Pawson
The unique insert of cellular and viral fms protein tyrosine kinase domains is dispensable for enzymatic and transforming activities.
The EMBO journal 1989;8(7):2029-37.
1989: A R Brooks-Wilson; E Ball; Tony Pawson
The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps.
Molecular and cellular biology 1989;9(5):2214-9.
1988: C Birek; Tony Pawson; Christopher A McCulloch; Howard C Tenenbaum
Dexamethasone effects on induction of neoplastic transformation by Fujinami sarcoma virus in an in vitro chick embryo periosteal model for osteosarcoma.
Cancer research 1988;48(24 Pt 1):7231-6.
1988: Michael F Moran; C A Koch; I Sadowski; Tony Pawson
Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity.
Oncogene 1988;3(6):665-72.
1988: Tony Pawson
Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.
Oncogene 1988;3(5):491-5.
1988: C Birek; Tony Pawson; Christopher A McCulloch; Howard C Tenenbaum
Neoplastic transformation of osteogenic cells: quantitative morphometric analysis of an in vitro model for osteosarcoma.
Carcinogenesis 1988;9(10):1785-91.
1988: I Sadowski; Tony Pawson; A Lagarde
v-fps protein-tyrosine kinase coordinately enhances the malignancy and growth factor responsiveness of pre-neoplastic lung fibroblasts.
Oncogene 1988;2(3):241-7.
1988: P A Greer; K Meckling-Hansen; Tony Pawson
The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity.
Molecular and cellular biology 1988;8(2):578-87.
1988: Tony Pawson; P Greer; M Moran; K Meckling-Hansen; A Brooks-Wilson; I Sadowski
Structure-function relationships in cellular and viral fps/fes cytoplasmic protein-tyrosine kinases.
Advances in experimental medicine and biology 1988;234():55-64.
1987: I Sadowski; Tony Pawson
Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli.
Oncogene 1987;1(2):181-91.