Tony Pawson

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Murphy James M; Hansen D Flemming; Wiesner Silke; Muhandiram D Ranjith; Borg Mikael; Smith Matthew J; Sicheri Frank; Kay Lewis E; Forman-Kay Julie D; Pawson Tony
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
Tan Chris Soon Heng; Pasculescu Adrian; Lim Wendell A; Pawson Tony; Bader Gary D; Linding Rune
Positive selection of tyrosine loss in metazoan evolution.
Jones Nina; New Laura A; Fortino Megan A; Eremina Vera; Ruston Julie; Blasutig Ivan M; Aoudjit Lamine; Zou Youling; Liu Xiuwen; Yu Guo-Liang; Takano Tomoko; Quaggin Susan E; Pawson Tony
Nck proteins maintain the adult glomerular filtration barrier.

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All Publications

2009: Murphy James M; Hansen D Flemming; Wiesner Silke; Muhandiram D Ranjith; Borg Mikael; Smith Matthew J; Sicheri Frank; Kay Lewis E; Forman-Kay Julie D; Pawson Tony
Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
Journal of molecular biology 2009;393(2):409-24.
2009: Tan Chris Soon Heng; Pasculescu Adrian; Lim Wendell A; Pawson Tony; Bader Gary D; Linding Rune
Positive selection of tyrosine loss in metazoan evolution.
Science (New York, N.Y.) 2009;325(5948):1686-8.
2009: Jones Nina; New Laura A; Fortino Megan A; Eremina Vera; Ruston Julie; Blasutig Ivan M; Aoudjit Lamine; Zou Youling; Liu Xiuwen; Yu Guo-Liang; Takano Tomoko; Quaggin Susan E; Pawson Tony
Nck proteins maintain the adult glomerular filtration barrier.
Journal of the American Society of Nephrology : JASN 2009;20(7):1533-43.
2009: Ho S K Y; Kovacevic N; Henkelman R M; Boyd A; Pawson T; Henderson J T
EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain.
Neuroscience 2009;160(4):784-95.
2009: Pawson Tony; Taylor Lorne
Protein phosphorylation goes negative.
Molecular cell 2009;34(2):139-40.
2009: Taylor Ian W; Linding Rune; Warde-Farley David; Liu Yongmei; Pesquita Catia; Faria Daniel; Bull Shelley; Pawson Tony; Morris Quaid; Wrana Jeffrey L
Dynamic modularity in protein interaction networks predicts breast cancer outcome.
Nature biotechnology 2009;27(2):199-204.
2009: MacNeil Lesley T; Hardy W Rod; Pawson Tony; Wrana Jeffrey L; Culotti Joseph G
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.
Nature neuroscience 2009;12(2):150-5.
2009: Tan Chris Soon Heng; Bodenmiller Bernd; Pasculescu Adrian; Jovanovic Marko; Hengartner Michael O; Jørgensen Claus; Bader Gary D; Aebersold Ruedi; Pawson Tony; Linding Rune
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.
Science signaling 2009;2(81):ra39.
2008: Bakal Chris; Linding Rune; Llense Flora; Heffern Elleard; Martin-Blanco Enrique; Pawson Tony; Perrimon Norbert
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.
Science (New York, N.Y.) 2008;322(5900):453-6.
2008: Ruusala Aino; Pawson Tony; Heldin Carl-Henrik; Aspenström Pontus
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
The Journal of biological chemistry 2008;283(44):30034-44.
2008: Filippakopoulos Panagis; Kofler Michael; Hantschel Oliver; Gish Gerald D; Grebien Florian; Salah Eidarus; Neudecker Philipp; Kay Lewis E; Turk Benjamin E; Superti-Furga Giulio; Pawson Tony; Knapp Stefan
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Cell 2008;134(5):793-803.
2008: Sonnberg Stephanie; Seet Bruce T; Pawson Tony; Fleming Stephen B; Mercer Andrew A
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10955-60.
2008: Traweger Andreas; Wiggin Giselle; Taylor Lorne; Tate Stephen A; Metalnikov Pavel; Pawson Tony
Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(30):10402-7.
2008: Lim Kim Buay; Bu Wenyu; Goh Wah Ing; Koh Esther; Ong Siew Hwa; Pawson Tony; Sudhaharan Thankiah; Ahmed Sohail
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.
The Journal of biological chemistry 2008;283(29):20454-72.
2008: Findlay Greg M; Pawson Tony
How is SOS activated? Let us count the ways.
Nature structural & molecular biology 2008;15(6):538-40.
2008: Lundgren T Kalle; Stenqvist Anna; Scott Rizaldy P; Pawson Tony; Ernfors Patrik
Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors.
Journal of cellular biochemistry 2008;104(3):879-94.
2008: Warner Neil; Wybenga-Groot Leanne E; Pawson Tony
Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays.
The FEBS journal 2008;275(10):2561-73.
2008: Stenqvist Anna; Lundgren T Kalle; Smith Matthew J; Hermanson Ola; Castelo-Branco Gonçalo; Pawson Tony; Ernfors Patrik
Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok.
Neuroscience letters 2008;435(1):11-6.
2008: To Ciric; Kulkarni Sarang; Pawson Tony; Honda Tadashi; Gribble Gordon W; Sporn Michael B; Wrana Jeffrey L; Di Guglielmo Gianni M
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.
The Journal of biological chemistry 2008;283(17):11700-13.
2008: Pawson Tony; Linding Rune
Network medicine.
FEBS letters 2008;582(8):1266-70.
2008: Huang Haiming; Li Lei; Wu Chenggang; Schibli David; Colwill Karen; Ma Sucan; Li Chengjun; Roy Protiva; Ho Krystina; Songyang Zhou; Pawson Tony; Gao Youhe; Li Shawn S-C
Defining the specificity space of the human SRC homology 2 domain.
Molecular & cellular proteomics : MCP 2008;7(4):768-84.
2008: Ursini-Siegel Josie; Hardy W Rod; Zuo Dongmei; Lam Sonya H L; Sanguin-Gendreau Virginie; Cardiff Robert D; Pawson Tony; Muller William J
ShcA signalling is essential for tumour progression in mouse models of human breast cancer.
The EMBO journal 2008;27(6):910-20.
2008: Blasutig Ivan M; New Laura A; Thanabalasuriar Ajitha; Dayarathna Thamara K; Goudreault Marilyn; Quaggin Susan E; Li Shawn S-C; Gruenheid Samantha; Jones Nina; Pawson Tony
Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.
Molecular and cellular biology 2008;28(6):2035-46.
2008: Linding Rune; Jensen Lars Juhl; Pasculescu Adrian; Olhovsky Marina; Colwill Karen; Bork Peer; Yaffe Michael B; Pawson Tony
NetworKIN: a resource for exploring cellular phosphorylation networks.
Nucleic acids research 2008;36(Database issue):D695-9.
2008: Miller Martin Lee; Jensen Lars Juhl; Diella Francesca; Jørgensen Claus; Tinti Michele; Li Lei; Hsiung Marilyn; Parker Sirlester A; Bordeaux Jennifer; Sicheritz-Ponten Thomas; Olhovsky Marina; Pasculescu Adrian; Alexander Jes; Knapp Stefan; Blom Nikolaj; Bork Peer; Li Shawn; Cesareni Gianni; Pawson Tony; Turk Benjamin E; Yaffe Michael B; Brunak Søren; Linding Rune
Linear motif atlas for phosphorylation-dependent signaling.
Science signaling 2008;1(35):ra2.
2008: Zogopoulos George; Jorgensen Claus; Bacani Julinor; Montpetit Alexandre; Lepage Pierre; Ferretti Vincent; Chad Lauren; Selvarajah Subani; Zanke Brent; Hudson Thomas J; Pawson Tony; Gallinger Steven
Germline EPHB2 receptor variants in familial colorectal cancer.
PloS one 2008;3(8):e2885.
2007: Fawcett James P; Georgiou John; Ruston Julie; Bladt Friedhelm; Sherman Andrew; Warner Neil; Saab Bechara J; Scott Rizaldy; Roder John C; Pawson Tony
Nck adaptor proteins control the organization of neuronal circuits important for walking.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20973-8.
2007: Kim Jinoh; Thanabalasuriar Ajitha; Chaworth-Musters Tessa; Fromme J Chris; Frey Elizabeth A; Lario Paula I; Metalnikov Pavel; Rizg Keyrillos; Thomas Nikhil A; Lee Sau Fung; Hartland Elizabeth L; Hardwidge Philip R; Pawson Tony; Strynadka Natalie C; Finlay B Brett; Schekman Randy; Gruenheid Samantha
The bacterial virulence factor NleA inhibits cellular protein secretion by disrupting mammalian COPII function.
Cell host & microbe 2007;2(3):160-71.
2007: Murphy James M; Korzhnev Dmitry M; Ceccarelli Derek F; Briant Douglas J; Zarrine-Afsar Arash; Sicheri Frank; Kay Lewis E; Pawson Tony
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14336-41.
2007: Lim Caesar S; Seet Bruce T; Ingham Robert J; Gish Gerald; Matskova Liudmila; Winberg Gösta; Ernberg Ingemar; Pawson Tony
The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.
Biochemistry 2007;46(35):9874-85.
2007: Hardy W Rod; Li Lingying; Wang Zhi; Sedy Jiri; Fawcett James; Frank Eric; Kucera Jan; Pawson Tony
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis.
Science (New York, N.Y.) 2007;317(5835):251-6.
2007: Jones Nina; Hardy W Rod; Friese Matthew B; Jorgensen Claus; Smith Matthew J; Woody Neil M; Burden Steven J; Pawson Tony
Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Molecular and cellular biology 2007;27(13):4759-73.
2007: Matskova L V; Helmstetter C; Ingham R J; Gish G; Lindholm C K; Ernberg I; Pawson T; Winberg G
The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein-Barr virus LMP2A membrane protein.
Oncogene 2007;26(34):4908-17.
2007: Linding Rune; Jensen Lars Juhl; Ostheimer Gerard J; van Vugt Marcel A T M; Jørgensen Claus; Miron Ioana M; Diella Francesca; Colwill Karen; Taylor Lorne; Elder Kelly; Metalnikov Pavel; Nguyen Vivian; Pasculescu Adrian; Jin Jing; Park Jin Gyoon; Samson Leona D; Woodgett James R; Russell Robert B; Bork Peer; Yaffe Michael B; Pawson Tony
Systematic discovery of in vivo phosphorylation networks.
Cell 2007;129(7):1415-26.
2007: Borg Mikael; Mittag Tanja; Pawson Tony; Tyers Mike; Forman-Kay Julie D; Chan Hue Sun
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9650-5.
2007: Ceccarelli Derek F J; Blasutig Ivan M; Goudreault Marilyn; Li Zhiqin; Ruston Julie; Pawson Tony; Sicheri Frank
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9.
The Journal of biological chemistry 2007;282(18):13864-74.
2007: Pawson Tony
Dynamic control of signaling by modular adaptor proteins.
Current opinion in cell biology 2007;19(2):112-6.
2007: Pawson T; Warner N
Oncogenic re-wiring of cellular signaling pathways.
Oncogene 2007;26(9):1268-75.
2007: Seet Bruce T; Berry Donna M; Maltzman Jonathan S; Shabason Jacob; Raina Monica; Koretzky Gary A; McGlade C Jane; Pawson Tony
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.
The EMBO journal 2007;26(3):678-89.
2006: Smith Matthew J; Hardy W Rod; Murphy James M; Jones Nina; Pawson Tony
Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.
Molecular and cellular biology 2006;26(22):8461-74.
2006: Wiesner Silke; Wybenga-Groot Leanne E; Warner Neil; Lin Hong; Pawson Tony; Forman-Kay Julie D; Sicheri Frank
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases.
The EMBO journal 2006;25(19):4686-96.
2006: Seet Bruce T; Dikic Ivan; Zhou Ming-Ming; Pawson Tony
Reading protein modifications with interaction domains.
Nature reviews. Molecular cell biology 2006;7(7):473-83.
2006: Chazaud Claire; Yamanaka Yojiro; Pawson Tony; Rossant Janet
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.
Developmental cell 2006;10(5):615-24.
2006: Wells Clark D; Fawcett James P; Traweger Andreas; Yamanaka Yojiro; Goudreault Marilyn; Elder Kelly; Kulkarni Sarang; Gish Gerald; Virag Cristina; Lim Caesar; Colwill Karen; Starostine Andrei; Metalnikov Pavel; Pawson Tony
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
Cell 2006;125(3):535-48.
2006: Jones Nina; Blasutig Ivan M; Eremina Vera; Ruston Julie M; Bladt Friedhelm; Li Hongping; Huang Haiming; Larose Louise; Li Shawn S-C; Takano Tomoko; Quaggin Susan E; Pawson Tony
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.
Nature 2006;440(7085):818-23.
2006: Kwan Jamie J; Warner Neil; Maini Joban; Chan Tung Kelvin W; Zakaria Hoshang; Pawson Tony; Donaldson Logan W
Saccharomyces cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction.
Journal of molecular biology 2006;356(1):142-54.
2006: Colwill Karen; Wells Clark D; Elder Kelly; Goudreault Marilyn; Hersi Kadija; Kulkarni Sarang; Hardy W Rod; Pawson Tony; Morin Gregg B
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites.
BMC biotechnology 2006;6():13.
2005: Gelkop Sigal; Gish Gerrald D; Babichev Yael; Pawson Tony; Isakov Noah
T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8123-32.
2005: Ingham Robert J; Raaijmakers Judith; Lim Caesar S H; Mbamalu Geraldine; Gish Gerald; Chen Fu; Matskova Liudmila; Ernberg Ingemar; Winberg Gösta; Pawson Tony
The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor.
The Journal of biological chemistry 2005;280(40):34133-42.
2005: Steven Robert; Zhang Lijia; Culotti Joseph; Pawson Tony
The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.
Genes & development 2005;19(17):2016-29.
2005: Ingham Robert J; Colwill Karen; Howard Caley; Dettwiler Sabine; Lim Caesar S H; Yu Joanna; Hersi Kadija; Raaijmakers Judith; Gish Gerald; Mbamalu Geraldine; Taylor Lorne; Yeung Benny; Vassilovski Galina; Amin Manish; Chen Fu; Matskova Liudmila; Winberg Gösta; Ernberg Ingemar; Linding Rune; O'donnell Paul; Starostine Andrei; Keller Walter; Metalnikov Pavel; Stark Chris; Pawson Tony
WW domains provide a platform for the assembly of multiprotein networks.
Molecular and cellular biology 2005;25(16):7092-106.
2005: Wiggin Giselle R; Fawcett James P; Pawson Tony
Polarity proteins in axon specification and synaptogenesis.
Developmental cell 2005;8(6):803-16.
2005: Pawson Tony; Linding Rune
Synthetic modular systems--reverse engineering of signal transduction.
FEBS letters 2005;579(8):1808-14.
2004: Smith Matthew J; Kulkarni Sarang; Pawson Tony
FF domains of CA150 bind transcription and splicing factors through multiple weak interactions.
Molecular and cellular biology 2004;24(21):9274-85.
2004: Cully Megan; Elia Andrew; Ong Siew-Hwa; Stambolic Vuk; Pawson Tony; Tsao Ming-Sound; Mak Tak W
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15358-63.
2004: Seet Bruce T; Pawson Tony
MAPK signaling: Sho business.
Current biology : CB 2004;14(17):R708-10.
2004: Kwan Jamie J; Warner Neil; Pawson Tony; Donaldson Logan W
The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50.
Journal of molecular biology 2004;342(2):681-93.
2004: Jin Jing; Smith F Donelson; Stark Chris; Wells Clark D; Fawcett James P; Kulkarni Sarang; Metalnikov Pavel; O'Donnell Paul; Taylor Paul; Taylor Lorne; Zougman Alexandre; Woodgett James R; Langeberg Lorene K; Scott John D; Pawson Tony
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Current biology : CB 2004;14(16):1436-50.
2004: Woodring Pamela J; Meisenhelder Jill; Johnson Sam A; Zhou Guo-Lei; Field Jeffrey; Shah Kavita; Bladt Friedhelm; Pawson Tony; Niki Masaru; Pandolfi Pier Paolo; Wang Jean Y J; Hunter Tony
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading.
The Journal of cell biology 2004;165(4):493-503.
2004: Kimura Yuki; Jones Nina; Klüppel Michael; Hirashima Masanori; Tachibana Kazunobu; Cohn Jason B; Wrana Jeffrey L; Pawson Tony; Bernstein Alan
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6015-20.
2004: Ingham Robert J; Gish Gerald; Pawson Tony
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.
Oncogene 2004;23(11):1972-84.
2004: Deng Wanyin; Puente José L; Gruenheid Samantha; Li Yuling; Vallance Bruce A; Vázquez Alejandra; Barba Jeannette; Ibarra J Antonio; O'Donnell Paul; Metalnikov Pavel; Ashman Keith; Lee Sansan; Goode David; Pawson Tony; Finlay B Brett
Dissecting virulence: systematic and functional analyses of a pathogenicity island.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3597-602.
2004: Gruenheid Samantha; Sekirov Inna; Thomas Nikhil A; Deng Wanyin; O'Donnell Paul; Goode David; Li Yuling; Frey Elizabeth A; Brown Nathaniel F; Metalnikov Pavel; Pawson Tony; Ashman Keith; Finlay B Brett
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7.
Molecular microbiology 2004;51(5):1233-49.
2004: Saucier Caroline; Khoury Hanane; Lai Ka-Man Venus; Peschard Pascal; Dankort David; Naujokas Monica A; Holash Jocelyn; Yancopoulos George D; Muller William J; Pawson Tony; Park Morag
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2345-50.
2004: Pawson Tony
Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems.
Cell 2004;116(2):191-203.
2003: Kubiseski Terrance J; Culotti Joe; Pawson Tony
Functional analysis of the Caenorhabditis elegans UNC-73B PH domain demonstrates a role in activation of the Rac GTPase in vitro and axon guidance in vivo.
Molecular and cellular biology 2003;23(19):6823-35.
2003: Howard Perry L; Chia Marie C; Del Rizzo Suzanne; Liu Fei-Fei; Pawson Tony
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11267-72.
2003: Mak Tak W; Shahinian Arda; Yoshinaga Steve K; Wakeham Andrew; Boucher Louis-Martin; Pintilie Melania; Duncan Gordon; Gajewska Beata U; Gronski Matthew; Eriksson Urs; Odermatt Bernhard; Ho Alexandra; Bouchard Denis; Whorisky John S; Jordana Manel; Ohashi Pamela S; Pawson Tony; Bladt Friedhelm; Tafuri Anna
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses.
Nature immunology 2003;4(8):765-72.
2003: Bladt Friedhelm; Aippersbach Elke; Gelkop Sigal; Strasser Geraldine A; Nash Piers; Tafuri Anna; Gertler Frank B; Pawson Tony
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.
Molecular and cellular biology 2003;23(13):4586-97.
2003: Pawson Tony
Organization of cell-regulatory systems through modular-protein-interaction domains.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2003;361(1807):1251-62.
2003: Kunath Tilo; Gish Gerald; Lickert Heiko; Jones Nina; Pawson Tony; Rossant Janet
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.
Nature biotechnology 2003;21(5):559-61.
2003: Pawson Tony; Nash Piers
Assembly of cell regulatory systems through protein interaction domains.
Science (New York, N.Y.) 2003;300(5618):445-52.
2003: Plant Pamela J; Fawcett James P; Lin Dan C C; Holdorf Amy D; Binns Kathleen; Kulkarni Sarang; Pawson Tony
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.
Nature cell biology 2003;5(4):301-8.
2003: Donaldson Ian; Martin Joel; de Bruijn Berry; Wolting Cheryl; Lay Vicki; Tuekam Brigitte; Zhang Shudong; Baskin Berivan; Bader Gary D; Michalickova Katerina; Pawson Tony; Hogue Christopher W V
PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine.
BMC bioinformatics 2003;4():11.
2003: Liu Qin; Berry Donna; Nash Piers; Pawson Tony; McGlade C Jane; Li Shawn Shun-Cheng
Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition.
Molecular cell 2003;11(2):471-81.
2003: Tong Jiefei; Elowe Sabine; Nash Piers; Pawson Tony
Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity.
The Journal of biological chemistry 2003;278(8):6111-9.
2002: Killeen Marie; Tong Jeifei; Krizus Aldis; Steven Robert; Scott Ian; Pawson Tony; Culotti Joseph
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.
Developmental biology 2002;251(2):348-66.
2002: Donaldson Logan W; Gish Gerald; Pawson Tony; Kay Lewis E; Forman-Kay Julie D
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14053-8.
2002: Pawson Tony
Regulation and targets of receptor tyrosine kinases.
European journal of cancer (Oxford, England : 1990) 2002;38 Suppl 5():S3-10.
2002: Berry Donna M; Nash Piers; Liu Stanley K-W; Pawson Tony; McGlade C Jane
A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.
Current biology : CB 2002;12(15):1336-41.
2002: Velazquez Laura; Cheng Alec M; Fleming Heather E; Furlonger Caren; Vesely Shirly; Bernstein Alan; Paige Christopher J; Pawson Tony
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.
The Journal of experimental medicine 2002;195(12):1599-611.
2002: Bladt Friedhelm; Tafuri Anna; Gelkop Sigal; Langille Lowell; Pawson Tony
Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6816-21.
2002: Pawson Tony; Raina Monica; Nash Piers
Interaction domains: from simple binding events to complex cellular behavior.
FEBS letters 2002;513(1):2-10.
2002: Hwang Peter M; Li Chengjun; Morra Massimo; Lillywhite Jennifer; Muhandiram D Ranjith; Gertler Frank; Terhorst Cox; Kay Lewis E; Pawson Tony; Forman-Kay Julie D; Li Shun-Cheng
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
The EMBO journal 2002;21(3):314-23.
2001: Henderson J T; Georgiou J; Jia Z; Robertson J; Elowe S; Roder J C; Pawson T
The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function.
Neuron 2001;32(6):1041-56.
2001: Pawson T; Gish G D; Nash P
SH2 domains, interaction modules and cellular wiring.
Trends in cell biology 2001;11(12):504-11.
2001: Nash P; Tang X; Orlicky S; Chen Q; Gertler F B; Mendenhall M D; Sicheri F; Pawson T; Tyers M
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
Nature 2001;414(6863):514-21.
2001: Ong S H; Dilworth S; Hauck-Schmalenberger I; Pawson T; Kiefer F
ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
The EMBO journal 2001;20(22):6327-36.
2001: Matskova L; Ernberg I; Pawson T; Winberg G
C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signal.
Journal of virology 2001;75(22):10941-9.
2001: Elowe S; Holland S J; Kulkarni S; Pawson T
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.
Molecular and cellular biology 2001;21(21):7429-41.
2001: Tong J; Killeen M; Steven R; Binns K L; Culotti J; Pawson T
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.
The Journal of biological chemistry 2001;276(44):40917-25.
2001: Wybenga-Groot L E; Baskin B; Ong S H; Tong J; Pawson T; Sicheri F
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.
Cell 2001;106(6):745-57.
2001: Gruenheid S; DeVinney R; Bladt F; Goosney D; Gelkop S; Gish G D; Pawson T; Finlay B B
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells.
Nature cell biology 2001;3(9):856-9.
2001: Saxton T M; Cheng A M; Ong S H; Lu Y; Sakai R; Cross J C; Pawson T
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.
Current biology : CB 2001;11(9):662-70.
2001: Vogel W F; Aszódi A; Alves F; Pawson T
Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development.
Molecular and cellular biology 2001;21(8):2906-17.
2001: Tafuri A; Shahinian A; Bladt F; Yoshinaga S K; Jordana M; Wakeham A; Boucher L M; Bouchard D; Chan V S; Duncan G; Odermatt B; Ho A; Itie A; Horan T; Whoriskey J S; Pawson T; Penninger J M; Ohashi P S; Mak T W
ICOS is essential for effective T-helper-cell responses.
Nature 2001;409(6816):105-9.
2001: Bader G D; Donaldson I; Wolting C; Ouellette B F; Pawson T; Hogue C W
BIND--The Biomolecular Interaction Network Database.
Nucleic acids research 2001;29(1):242-5.
2000: Sakai R; Henderson J T; O'Bryan J P; Elia A J; Saxton T M; Pawson T
The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.
Neuron 2000;28(3):819-33.
2000: Winberg G; Matskova L; Chen F; Plant P; Rotin D; Gish G; Ingham R; Ernberg I; Pawson T
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.
Molecular and cellular biology 2000;20(22):8526-35.
2000: Fawcett J; Pawson T
Signal transduction. N-WASP regulation--the sting in the tail.
Science (New York, N.Y.) 2000;290(5492):725-6.
2000: Lin D; Edwards A S; Fawcett J P; Mbamalu G; Scott J D; Pawson T
A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity.
Nature cell biology 2000;2(8):540-7.
2000: Velazquez L; Gish G D; van Der Geer P; Taylor L; Shulman J; Pawson T
The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.
Blood 2000;96(1):132-8.
2000: Binns K L; Taylor P P; Sicheri F; Pawson T; Holland S J
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.
Molecular and cellular biology 2000;20(13):4791-805.
2000: Kimber M S; Nachman J; Cunningham A M; Gish G D; Pawson T; Pai E F
Structural basis for specificity switching of the Src SH2 domain.
Molecular cell 2000;5(6):1043-9.
2000: Bashaw G J; Kidd T; Murray D; Pawson T; Goodman C S
Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.
Cell 2000;101(7):703-15.
2000: Lai K M; Pawson T
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo.
Genes & development 2000;14(9):1132-45.
2000: Pawson T; Nash P
Protein-protein interactions define specificity in signal transduction.
Genes & development 2000;14(9):1027-47.
2000: Kulkarni S V; Gish G; van der Geer P; Henkemeyer M; Pawson T
Role of p120 Ras-GAP in directed cell movement.
The Journal of cell biology 2000;149(2):457-70.
2000: Zwahlen C; Li S C; Kay L E; Pawson T; Forman-Kay J D
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.
The EMBO journal 2000;19(7):1505-15.
2000: Saxton T M; Ciruna B G; Holmyard D; Kulkarni S; Harpal K; Rossant J; Pawson T
The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.
Nature genetics 2000;24(4):420-3.
2000: Vogel W; Brakebusch C; Fässler R; Alves F; Ruggiero F; Pawson T
Discoidin domain receptor 1 is activated independently of beta(1) integrin.
The Journal of biological chemistry 2000;275(8):5779-84.
1999: Wang X; Roy P J; Holland S J; Zhang L W; Culotti J G; Pawson T
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor.
Molecular cell 1999;4(6):903-13.
1999: Forman-Kay J D; Pawson T
Diversity in protein recognition by PTB domains.
Current opinion in structural biology 1999;9(6):690-5.
1999: Li S C; Gish G; Yang D; Coffey A J; Forman-Kay J D; Ernberg I; Kay L E; Pawson T
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.
Current biology : CB 1999;9(23):1355-62.
1999: Rauh M J; Blackmore V; Andrechek E R; Tortorice C G; Daly R; Lai V K; Pawson T; Cardiff R D; Siegel P M; Muller W J
Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein.
Molecular and cellular biology 1999;19(12):8169-79.
1999: Pawson T; Saxton T M
Signaling networks--do all roads lead to the same genes?
Cell 1999;97(6):675-8.
1999: Saxton T M; Pawson T
Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3790-5.
1999: Lin D; Gish G D; Songyang Z; Pawson T
The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif.
The Journal of biological chemistry 1999;274(6):3726-33.
1999: Stapleton D; Balan I; Pawson T; Sicheri F
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
Nature structural biology 1999;6(1):44-9.
1998: Cheng A M; Saxton T M; Sakai R; Kulkarni S; Mbamalu G; Vogel W; Tortorice C G; Cardiff R D; Cross J C; Muller W J; Pawson T
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
Cell 1998;95(6):793-803.
1998: Li S C; Zwahlen C; Vincent S J; McGlade C J; Kay L E; Pawson T; Forman-Kay J D
Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.
Nature structural biology 1998;5(12):1075-83.
1998: Oldenhof J; Vickery R; Anafi M; Oak J; Ray A; Schoots O; Pawson T; von Zastrow M; Van Tol H H
SH3 binding domains in the dopamine D4 receptor.
Biochemistry 1998;37(45):15726-36.
1998: Kiefer F; Brumell J; Al-Alawi N; Latour S; Cheng A; Veillette A; Grinstein S; Pawson T
The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils.
Molecular and cellular biology 1998;18(7):4209-20.
1998: Steven R; Kubiseski T J; Zheng H; Kulkarni S; Mancillas J; Ruiz Morales A; Hogue C W; Pawson T; Culotti J
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.
Cell 1998;92(6):785-95.
1998: Holland S J; Peles E; Pawson T; Schlessinger J
Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.
Current opinion in neurobiology 1998;8(1):117-27.
1997: Vogel W; Gish G D; Alves F; Pawson T
The discoidin domain receptor tyrosine kinases are activated by collagen.
Molecular cell 1997;1(1):13-23.
1997: Pawson T; Scott J D
Signaling through scaffold, anchoring, and adaptor proteins.
Science (New York, N.Y.) 1997;278(5346):2075-80.
1997: Anafi M; Kiefer F; Gish G D; Mbamalu G; Iscove N N; Pawson T
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
The Journal of biological chemistry 1997;272(44):27804-11.
1997: Cheng A M; Negishi I; Anderson S J; Chan A C; Bolen J; Loh D Y; Pawson T
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9797-801.
1997: Holland S J; Gale N W; Gish G D; Roth R A; Songyang Z; Cantley L C; Henkemeyer M; Yancopoulos G D; Pawson T
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.
The EMBO journal 1997;16(13):3877-88.
1997: Li S C; Songyang Z; Vincent S J; Zwahlen C; Wiley S; Cantley L; Kay L E; Forman-Kay J; Pawson T
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7204-9.
1997: Saxton T M; Henkemeyer M; Gasca S; Shen R; Rossi D J; Shalaby F; Feng G S; Pawson T
Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.
The EMBO journal 1997;16(9):2352-64.
1997: van der Geer P; Henkemeyer M; Jacks T; Pawson T
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.
Molecular and cellular biology 1997;17(4):1840-7.
1997: Kubiseski T J; Chook Y M; Parris W E; Rozakis-Adcock M; Pawson T
High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate.
The Journal of biological chemistry 1997;272(3):1799-804.
1996: Kiefer F; Tibbles L A; Anafi M; Janssen A; Zanke B W; Lassam N; Pawson T; Woodgett J R; Iscove N N
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
The EMBO journal 1996;15(24):7013-25.
1996: Piao X; Paulson R; van der Geer P; Pawson T; Bernstein A
Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14665-9.
1996: Li S C; Lai K M; Gish G D; Parris W E; van der Geer P; Forman-Kay J; Pawson T
Characterization of the phosphotyrosine-binding domain of the Drosophila Shc protein.
The Journal of biological chemistry 1996;271(50):31855-62.
1996: Rosen M K; Gardner K H; Willis R C; Parris W E; Pawson T; Kay L E
Selective methyl group protonation of perdeuterated proteins.
Journal of molecular biology 1996;263(5):627-36.
1996: Orioli D; Henkemeyer M; Lemke G; Klein R; Pawson T
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.
The EMBO journal 1996;15(22):6035-49.
1996: Chook Y M; Gish G D; Kay C M; Pai E F; Pawson T
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.
The Journal of biological chemistry 1996;271(48):30472-8.
1996: van der Geer P; Wiley S; Gish G D; Pawson T
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
Current biology : CB 1996;6(11):1435-44.
1996: Holland S J; Gale N W; Mbamalu G; Yancopoulos G D; Henkemeyer M; Pawson T
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands.
Nature 1996;383(6602):722-5.
1996: Colwill K; Feng L L; Yeakley J M; Gish G D; Cáceres J F; Pawson T; Fu X D
SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.
The Journal of biological chemistry 1996;271(40):24569-75.
1996: Roche S; McGlade J; Jones M; Gish G D; Pawson T; Courtneidge S A
Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.
The EMBO journal 1996;15(18):4940-8.
1996: Mallick-Wood C A; Pao W; Cheng A M; Lewis J M; Kulkarni S; Bolen J B; Rowley B; Tigelaar R E; Pawson T; Hayday A C
Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9704-9.
1996: Anafi M; Rosen M K; Gish G D; Kay L E; Pawson T
A potential SH3 domain-binding site in the Crk SH2 domain.
The Journal of biological chemistry 1996;271(35):21365-74.
1996: Gale N W; Holland S J; Valenzuela D M; Flenniken A; Pan L; Ryan T E; Henkemeyer M; Strebhardt K; Hirai H; Wilkinson D G; Pawson T; Davis S; Yancopoulos G D
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.
Neuron 1996;17(1):9-19.
1996: Henkemeyer M; Orioli D; Henderson J T; Saxton T M; Roder J; Pawson T; Klein R
Nuk controls pathfinding of commissural axons in the mammalian central nervous system.
Cell 1996;86(1):35-46.
1996: Guha A; Lau N; Huvar I; Gutmann D; Provias J; Pawson T; Boss G
Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.
Oncogene 1996;12(3):507-13.
1996: van der Geer P; Wiley S; Gish G D; Lai V K; Stephens R; White M F; Kaplan D; Pawson T
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):963-8.
1996: Colwill K; Pawson T; Andrews B; Prasad J; Manley J L; Bell J C; Duncan P I
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
The EMBO journal 1996;15(2):265-75.
1995: Songyang Z; Gish G; Mbamalu G; Pawson T; Cantley L C
A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
The Journal of biological chemistry 1995;270(44):26029-32.
1995: Cheng A M; Rowley B; Pao W; Hayday A; Bolen J B; Pawson T
Syk tyrosine kinase required for mouse viability and B-cell development.
Nature 1995;378(6554):303-6.
1995: Rozakis-Adcock M; van der Geer P; Mbamalu G; Pawson T
MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.
Oncogene 1995;11(7):1417-26.
1995: Henkemeyer M; Rossi D J; Holmyard D P; Puri M C; Mbamalu G; Harpal K; Shih T S; Jacks T; Pawson T
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.
Nature 1995;377(6551):695-701.
1995: Lai K M; Olivier J P; Gish G D; Henkemeyer M; McGlade J; Pawson T
A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.
Molecular and cellular biology 1995;15(9):4810-8.
1995: van der Geer P; Pawson T
The PTB domain: a new protein module implicated in signal transduction.
Trends in biochemical sciences 1995;20(7):277-80.
1995: Raabe T; Olivier J P; Dickson B; Liu X; Gish G D; Pawson T; Hafen E
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.
The EMBO journal 1995;14(11):2509-18.
1995: van der Geer P; Wiley S; Lai V K; Olivier J P; Gish G D; Stephens R; Kaplan D; Shoelson S; Pawson T
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides.
Current biology : CB 1995;5(4):404-12.
1995: Lanfrancone L; Pelicci G; Brizzi M F; Aronica M G; Casciari C; Giuli S; Pegoraro L; Pawson T; Pelicci P G; Arouica M G
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.
Oncogene 1995;10(5):907-17.
1995: Rosen M K; Yamazaki T; Gish G D; Kay C M; Pawson T; Kay L E
Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein.
Nature 1995;374(6521):477-9.
1995: Larose L; Gish G; Pawson T
Construction of an SH2 domain-binding site with mixed specificity.
The Journal of biological chemistry 1995;270(8):3858-62.
1995: Pawson T
Protein modules and signalling networks.
Nature 1995;373(6515):573-80.
1995: Gish G; Larose L; Shen R; Pawson T
Biochemical analysis of SH2 domain-mediated protein interactions.
Methods in enzymology 1995;254():503-23.
1994: Salcini A E; McGlade J; Pelicci G; Nicoletti I; Pawson T; Pelicci P G
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.
Oncogene 1994;9(10):2827-36.
1994: Tauchi T; Feng G S; Marshall M S; Shen R; Mantel C; Pawson T; Broxmeyer H E
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
The Journal of biological chemistry 1994;269(40):25206-11.
1994: Feng G S; Shen R; Heng H H; Tsui L C; Kazlauskas A; Pawson T
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp.
Oncogene 1994;9(6):1545-50.
1994: Marengere L E; Songyang Z; Gish G D; Schaller M D; Parsons J T; Stern M J; Cantley L C; Pawson T
SH2 domain specificity and activity modified by a single residue.
Nature 1994;369(6480):502-5.
1994: Tauchi T; Feng G S; Shen R; Song H Y; Donner D; Pawson T; Broxmeyer H E
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.
The Journal of biological chemistry 1994;269(21):15381-7.
1994: Pascal S M; Singer A U; Gish G; Yamazaki T; Shoelson S E; Pawson T; Kay L E; Forman-Kay J D
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell 1994;77(3):461-72.
1994: Farrow N A; Muhandiram R; Singer A U; Pascal S M; Kay C M; Gish G; Shoelson S E; Pawson T; Forman-Kay J D; Kay L E
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation.
Biochemistry 1994;33(19):5984-6003.
1994: Henkemeyer M; Marengere L E; McGlade J; Olivier J P; Conlon R A; Holmyard D P; Letwin K; Pawson T
Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.
Oncogene 1994;9(4):1001-14.
1994: Songyang Z; Shoelson S E; McGlade J; Olivier P; Pawson T; Bustelo X R; Barbacid M; Sabe H; Hanafusa H; Yi T
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Molecular and cellular biology 1994;14(4):2777-85.
1994: Puil L; Liu J; Gish G; Mbamalu G; Bowtell D; Pelicci P G; Arlinghaus R; Pawson T
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
The EMBO journal 1994;13(4):764-73.
1994: Pawson T
Tyrosine kinase signalling pathways.
Princess Takamatsu symposia 1994;24():303-22.
1994: Marengere L E; Pawson T
Structure and function of SH2 domains.
Journal of cell science. Supplement 1994;18():97-104.
1994: Pawson T
SH2 and SH3 domains in signal transduction.
Advances in cancer research 1994;64():87-110.
1994: Liu X; Pawson T
Biochemistry of the Src protein-tyrosine kinase: regulation by SH2 and SH3 domains.
Recent progress in hormone research 1994;49():149-60.
1993: Kozlowski M; Mlinaric-Rascan I; Feng G S; Shen R; Pawson T; Siminovitch K A
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.
The Journal of experimental medicine 1993;178(6):2157-63.
1993: Lhoták V; Pawson T
Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.
Molecular and cellular biology 1993;13(11):7071-9.
1993: Stern M J; Marengere L E; Daly R J; Lowenstein E J; Kokel M; Batzer A; Olivier P; Pawson T; Schlessinger J
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
Molecular biology of the cell 1993;4(11):1175-88.
1993: Larose L; Gish G; Shoelson S; Pawson T
Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1.
Oncogene 1993;8(9):2493-9.
1993: Liu X; Marengere L E; Koch C A; Pawson T
The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.
Molecular and cellular biology 1993;13(9):5225-32.
1993: McGlade J; Brunkhorst B; Anderson D; Mbamalu G; Settleman J; Dedhar S; Rozakis-Adcock M; Chen L B; Pawson T
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.
The EMBO journal 1993;12(8):3073-81.
1993: Segatto O; Pelicci G; Giuli S; Digiesi G; Di Fiore P P; McGlade J; Pawson T; Pelicci P G
Shc products are substrates of erbB-2 kinase.
Oncogene 1993;8(8):2105-12.
1993: Pawson T; Schlessingert J
SH2 and SH3 domains.
Current biology : CB 1993;3(7):434-42.
1993: Pawson T; Olivier P; Rozakis-Adcock M; McGlade J; Henkemeyer M
Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):279-85.
1993: Payne G; Shoelson S E; Gish G D; Pawson T; Walsh C T
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):4902-6.
1993: Rozakis-Adcock M; Fernley R; Wade J; Pawson T; Bowtell D
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
Nature 1993;363(6424):83-5.
1993: Liu X; Brodeur S R; Gish G; Songyang Z; Cantley L C; Laudano A P; Pawson T
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.
Oncogene 1993;8(5):1119-26.
1993: Olivier J P; Raabe T; Henkemeyer M; Dickson B; Mbamalu G; Margolis B; Schlessinger J; Hafen E; Pawson T
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
Cell 1993;73(1):179-91.
1993: Pronk G J; McGlade J; Pelicci G; Pawson T; Bos J L
Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins.
The Journal of biological chemistry 1993;268(8):5748-53.
1993: Feng G S; Hui C C; Pawson T
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.
Science (New York, N.Y.) 1993;259(5101):1607-11.
1993: Reith A D; Ellis C; Maroc N; Pawson T; Bernstein A; Dubreuil P
'W' mutant forms of the Fms receptor tyrosine kinase act in a dominant manner to suppress CSF-1 dependent cellular transformation.
Oncogene 1993;8(1):45-53.
1992: Marengere L E; Pawson T
Identification of residues in GTPase-activating protein Src homology 2 domains that control binding to tyrosine phosphorylated growth factor receptors and p62.
The Journal of biological chemistry 1992;267(32):22779-86.
1992: Pawson T; Gish G D
SH2 and SH3 domains: from structure to function.
Cell 1992;71(3):359-62.
1992: McGlade J; Cheng A; Pelicci G; Pelicci P G; Pawson T
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8869-73.
1992: Meckling-Gill K A; Yee S P; Schrader J W; Pawson T
A retrovirus encoding the v-fps protein-tyrosine kinase induces factor-independent growth and tumorigenicity in FDC-P1 cells.
Biochimica et biophysica acta 1992;1137(1):65-72.
1992: Letwin K; Mizzen L; Motro B; Ben-David Y; Bernstein A; Pawson T
A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.
The EMBO journal 1992;11(10):3521-31.
1992: Pelicci G; Lanfrancone L; Grignani F; McGlade J; Cavallo F; Forni G; Nicoletti I; Grignani F; Pawson T; Pelicci P G
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Cell 1992;70(1):93-104.
1992: Douville E M; Afar D E; Howell B W; Letwin K; Tannock L; Ben-David Y; Pawson T; Bell J C
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.
Molecular and cellular biology 1992;12(6):2681-9.
1992: Puil L; Pawson T
Vagaries of vav.
Current biology : CB 1992;2(5):275-7.
1992: Reedijk M; Liu X; van der Geer P; Letwin K; Waterfield M D; Hunter T; Pawson T
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.
The EMBO journal 1992;11(4):1365-72.
1992: Koch C A; Moran M F; Anderson D; Liu X Q; Mbamalu G; Pawson T
Multiple SH2-mediated interactions in v-src-transformed cells.
Molecular and cellular biology 1992;12(3):1366-74.
1991: Reith A D; Ellis C; Lyman S D; Anderson D M; Williams D E; Bernstein A; Pawson T
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.
The EMBO journal 1991;10(9):2451-9.
1991: Ellis C; Liu X Q; Anderson D; Abraham N; Veillette A; Pawson T
Tyrosine phosphorylation of GAP and GAP-associated proteins in lymphoid and fibroblast cells expressing lck.
Oncogene 1991;6(6):895-901.
1991: Rottapel R; Reedijk M; Williams D E; Lyman S D; Anderson D M; Pawson T; Bernstein A
The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.
Molecular and cellular biology 1991;11(6):3043-51.
1991: Lhoták V; Greer P; Letwin K; Pawson T
Characterization of elk, a brain-specific receptor tyrosine kinase.
Molecular and cellular biology 1991;11(5):2496-502.
1991: Liu X Q; Pawson T
The epidermal growth factor receptor phosphorylates GTPase-activating protein (GAP) at Tyr-460, adjacent to the GAP SH2 domains.
Molecular and cellular biology 1991;11(5):2511-6.
1991: Koch C A; Anderson D; Moran M F; Ellis C; Pawson T
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
Science (New York, N.Y.) 1991;252(5006):668-74.
1991: Moran M F; Polakis P; McCormick F; Pawson T; Ellis C
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
Molecular and cellular biology 1991;11(4):1804-12.
1991: Ben-David Y; Letwin K; Tannock L; Bernstein A; Pawson T
A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.
The EMBO journal 1991;10(2):317-25.
1990: Moran M F; Koch C A; Anderson D; Ellis C; England L; Martin G S; Pawson T
Src homology region 2 domains direct protein-protein interactions in signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8622-6.
1990: Anderson D; Koch C A; Grey L; Ellis C; Moran M F; Pawson T
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors.
Science (New York, N.Y.) 1990;250(4983):979-82.
1990: Reedijk M; Liu X Q; Pawson T
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
Molecular and cellular biology 1990;10(11):5601-8.
1990: Greer P; Maltby V; Rossant J; Bernstein A; Pawson T
Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice.
Molecular and cellular biology 1990;10(6):2521-7.
1990: Wildenhain Y; Pawson T; Blackstein M E; Andrulis I L
p185neu is phosphorylated on tyrosine in human primary breast tumors which overexpress neu/erbB-2.
Oncogene 1990;5(6):879-83.
1990: Ellis C; Moran M; McCormick F; Pawson T
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases.
Nature 1990;343(6256):377-81.
1989: Pawson T; Letwin K; Lee T; Hao Q L; Heisterkamp N; Groffen J
The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family.
Molecular and cellular biology 1989;9(12):5722-5.
1989: Yee S P; Mock D; Greer P; Maltby V; Rossant J; Bernstein A; Pawson T
Lymphoid and mesenchymal tumors in transgenic mice expressing the v-fps protein-tyrosine kinase.
Molecular and cellular biology 1989;9(12):5491-9.
1989: Koch C A; Moran M; Sadowski I; Pawson T
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
Molecular and cellular biology 1989;9(10):4131-40.
1989: Lavigueur A; Maltby V; Mock D; Rossant J; Pawson T; Bernstein A
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.
Molecular and cellular biology 1989;9(9):3982-91.
1989: Yee S P; Mock D; Maltby V; Silver M; Rossant J; Bernstein A; Pawson T
Cardiac and neurological abnormalities in v-fps transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5873-7.
1989: Taylor G R; Reedijk M; Rothwell V; Rohrschneider L; Pawson T
The unique insert of cellular and viral fms protein tyrosine kinase domains is dispensable for enzymatic and transforming activities.
The EMBO journal 1989;8(7):2029-37.
1989: Brooks-Wilson A R; Ball E; Pawson T
The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps.
Molecular and cellular biology 1989;9(5):2214-9.
1988: Birek C; Pawson T; McCulloch C A; Tenenbaum H C
Dexamethasone effects on induction of neoplastic transformation by Fujinami sarcoma virus in an in vitro chick embryo periosteal model for osteosarcoma.
Cancer research 1988;48(24 Pt 1):7231-6.
1988: Moran M F; Koch C A; Sadowski I; Pawson T
Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity.
Oncogene 1988;3(6):665-72.
1988: Pawson T
Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.
Oncogene 1988;3(5):491-5.
1988: Birek C; Pawson T; McCulloch C A; Tenenbaum H C
Neoplastic transformation of osteogenic cells: quantitative morphometric analysis of an in vitro model for osteosarcoma.
Carcinogenesis 1988;9(10):1785-91.
1988: Sadowski I; Pawson T; Lagarde A
v-fps protein-tyrosine kinase coordinately enhances the malignancy and growth factor responsiveness of pre-neoplastic lung fibroblasts.
Oncogene 1988;2(3):241-7.
1988: Greer P A; Meckling-Hansen K; Pawson T
The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity.
Molecular and cellular biology 1988;8(2):578-87.
1988: Pawson T; Greer P; Moran M; Meckling-Hansen K; Brooks-Wilson A; Sadowski I
Structure-function relationships in cellular and viral fps/fes cytoplasmic protein-tyrosine kinases.
Advances in experimental medicine and biology 1988;234():55-64.
1987: Sadowski I; Pawson T
Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli.
Oncogene 1987;1(2):181-91.

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