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Kathleen Berkner

Research Profile

Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

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Ronald E Hector; Alo Ray; Kathleen L Berkner; Bo-Ruei Chen; Rebecca Shtofman; Kurt Runge
Mec1p associates with functionally compromised telomeres.
Mark A Rishavy; Kathleen L Berkner
Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase.
Mark A Rishavy; Aisulu Usubalieva; Kevin W Hallgren; Kathleen L Berkner
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation.

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All Publications

2012: Ronald E Hector; Alo Ray; Kathleen L Berkner; Bo-Ruei Chen; Rebecca Shtofman; Kurt Runge
Mec1p associates with functionally compromised telomeres.
Chromosoma 2012;121(3):277-90.
2012: Mark A Rishavy; Kathleen L Berkner
Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase.
Advances in nutrition (Bethesda, Md.) 2012;3(2):135-48.
2011: Mark A Rishavy; Aisulu Usubalieva; Kevin W Hallgren; Kathleen L Berkner
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation.
The Journal of biological chemistry 2011;286(9):7267-78.
2009: Qiaoli Li; Dorothy K Grange; Nicole L Armstrong; Alison J Whelan; Maria Y Hurley; Mark A Rishavy; Kevin W Hallgren; Kathleen L Berkner; Leon J Schurgers; Qiujie Jiang; Jouni Uitto
Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.
The Journal of investigative dermatology 2009;129(3):553-63.
2008: Mark A Rishavy; Kathleen L Berkner
Insight into the coupling mechanism of the vitamin K-dependent carboxylase: mutation of histidine 160 disrupts glutamic acid carbanion formation and efficient coupling of vitamin K epoxidation to glutamic acid carboxylation.
Biochemistry 2008;47(37):9836-46.
2008: Kathleen L Berkner
Vitamin K-dependent carboxylation.
Vitamins and hormones 2008;78():131-56.
2007: Ronald E Hector; Rebecca L Shtofman; Alo Ray; Bo-Ruei Chen; Thihan Nyun; Kathleen L Berkner; Kurt Runge
Tel1p preferentially associates with short telomeres to stimulate their elongation.
Molecular cell 2007;27(5):851-8.
2006: Mark A Rishavy; Kevin W Hallgren; Anna V Yakubenko; Rebecca L Shtofman; Kurt Runge; Kathleen L Berkner
Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation.
Biochemistry 2006;45(44):13239-48.
2006: Dhouha Darghouth; Kevin W Hallgren; Rebecca L Shtofman; Amel Mrad; Youssef Gharbi; Ahmed Maherzi; Radhia Kastally; Sophie LeRicousse; Kathleen L Berkner; Jean-Philippe Rosa
Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency.
Blood 2006;108(6):1925-31.
2006: Kevin W Hallgren; Wen Qian; Anna V Yakubenko; Kurt Runge; Kathleen L Berkner
r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.
Biochemistry 2006;45(17):5587-98.
2005: Mark A Rishavy; Kevin W Hallgren; Anna V Yakubenko; Richard L Zuerner; Kurt Runge; Kathleen L Berkner
The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation.
The Journal of biological chemistry 2005;280(41):34870-7.
2005: Kathleen L Berkner
The vitamin K-dependent carboxylase.
Annual review of nutrition 2005;25():127-49.
2004: Kathleen L Berkner; Kurt Runge
The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis.
Journal of thrombosis and haemostasis : JTH 2004;2(12):2118-32.
2004: Mark A Rishavy; B Nirmala Pudota; Kevin W Hallgren; Wen Qian; Anna V Yakubenko; Jee-Hyeon Song; Kurt Runge; Kathleen L Berkner
A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13732-7.
2003: Alo Ray; Ronald E Hector; Nilanjan Roy; Jee-Hyeon Song; Kathleen L Berkner; Kurt Runge
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.
Nature genetics 2003;33(4):522-6.
2002: Kevin W Hallgren; Eric L Hommema; Beth A McNally; Kathleen L Berkner
Carboxylase overexpression effects full carboxylation but poor release and secretion of factor IX: implications for the release of vitamin K-dependent proteins.
Biochemistry 2002;41(50):15045-55.
2001: B Nirmala Pudota; Eric L Hommema; Kevin W Hallgren; Beth A McNally; S Lee; Kathleen L Berkner
Identification of sequences within the gamma-carboxylase that represent a novel contact site with vitamin K-dependent proteins and that are required for activity.
The Journal of biological chemistry 2001;276(50):46878-86.
2001: Olga I Stenina; B Nirmala Pudota; Beth A McNally; Eric L Hommema; Kathleen L Berkner
Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo.
Biochemistry 2001;40(34):10301-9.
2000: B Nirmala Pudota; Masaru Miyagi; Kevin W Hallgren; Karen A West; John W Crabb; Kunio S Misono; Kathleen L Berkner
Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13033-8.
2000: Kathleen L Berkner
The vitamin K-dependent carboxylase.
The Journal of nutrition 2000;130(8):1877-80.
1999: Kunio S Misono; N Sivasubramanian; Kathleen L Berkner; Xiaolun Zhang
Expression and purification of the extracellular ligand-binding domain of the atrial natriuretic peptide (ANP) receptor: monovalent binding with ANP induces 2:2 complexes.
Biochemistry 1999;38(2):516-23.
1998: Kathleen L Berkner; B Nirmala Pudota
Vitamin K-dependent carboxylation of the carboxylase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):466-71.
1997: Kathleen L Berkner; Beth A McNally
Purification of vitamin K-dependent carboxylase from cultured cells.
Methods in enzymology 1997;282():313-33.