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David Pearce

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Rama Soundararajan; Jian Wang; Tim Ziera; Steffen A Borden; Eric Koo; Karen Ling; David Pearce
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
Rama Soundararajan; Ming Lu; David Pearce
Organization of the ENaC-regulatory machinery.
Rama Soundararajan; David Pearce; Tim Ziera
The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport.

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All Publications

2012: Rama Soundararajan; Jian Wang; Tim Ziera; Steffen A Borden; Eric Koo; Karen Ling; David Pearce
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
The Journal of biological chemistry 2012;287(39):33014-25.
2012: Rama Soundararajan; Ming Lu; David Pearce
Organization of the ENaC-regulatory machinery.
Critical reviews in biochemistry and molecular biology 2012;47(4):349-59.
2012: Rama Soundararajan; David Pearce; Tim Ziera
The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport.
Molecular and cellular endocrinology 2012;350(2):242-7.
2012: Evi Schmid; Ekaterina Shumilina; Kalina Szteyn; Leonid Tyan; Wenting Yang; Christina Leibrock; Meerim K Nurbaeva; David Pearce; Antonella Russo; madhuri bhandaru; Florian Lang
SGK3 regulates Ca(2+) entry and migration of dendritic cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;30(6):1423-35.
2011: Li-Jun Yao; Jian Wang; Katherine Y Yang; Morris J Birnbaum; Krishna M Boini; Gian Luca Colussi; Michael S German; Atif Kidwai; Florian Lang; James McCormick; David Pearce
Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
Molecular endocrinology (Baltimore, Md.) 2011;25(12):2106-18.
2011: madhuri bhandaru; Jürg Biber; Paola Capuano; Michael Föller; Dan Yang Huang; Martin S Judenhofer; Daniela S Kempe; Ganesh Pathare; David Pearce; Bernd J Pichler; Leticia Quintanilla-Martinez; anand rotte; Balasaheb Siraskar; Mentor Sopjani; Gerti Stange; Leonid Tyan; Carsten A Wagner; Ioana Alesutan; Florian Lang
Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.
Kidney international 2011;80(1):61-7.
2011: Venkanna Pasham; anand rotte; madhuri bhandaru; Melanie Eichenmüller; Henning Fröhlich; Andreas F Mack; Diwakar Bobbala; Wenting Yang; David Pearce; Florian Lang
Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.
Journal of gastroenterology 2011;46(3):305-17.
2010: Rama Soundararajan; Jian Wang; Daniël Melters; David Pearce
Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization.
The Journal of biological chemistry 2010;285(51):39905-13.
2010: Alan C Pao; Aditi Bhargava; Francesca Di Sole; Raymond Quigley; Xinli Shao; Jian Wang; Sheela Thomas; Jianning Zhang; Mingjun Shi; John W Funder; Orson W Moe; David Pearce
Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.
American journal of physiology. Renal physiology 2010;299(6):F1496-506.
2010: Irina M Zemtsova; Nicole Heise; Henning Fröhlich; Syed M Qadri; Yuliya Kucherenko; Krishna M Boini; David Pearce; Ekaterina Shumilina; Florian Lang
Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3.
American journal of physiology. Cell physiology 2010;299(5):C1007-14.
2010: Kenneth R Hallows; Vivek Bhalla; Nicholas M Oyster; Marjolein A Wijngaarden; Jeffrey K Lee; Hui Li; Sindhu Chandran; Xiaoyu Xia; Zhirong Huang; Robert J Chalkley; Alma L Burlingame; David Pearce
Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel.
The Journal of biological chemistry 2010;285(28):21671-8.
2010: Ming Lu; Jian Wang; Kevin T Jones; Harlan E Ives; Morris E Feldman; Li-jun Yao; Kevan M Shokat; Kaveh Ashrafi; David Pearce
mTOR complex-2 activates ENaC by phosphorylating SGK1.
Journal of the American Society of Nephrology : JASN 2010;21(5):811-8.
2010: Daniela S Kempe; Teresa F Ackermann; Morris J Birnbaum; Michael Föller; Henning Fröhlich; David Pearce; Gulab Siraskar; Michael Stübs; Anja T Umbach; Harald Völkl; Florian Weiss; Florian Lang
Regulation of renal tubular glucose reabsorption by Akt2/PKBβ.
American journal of physiology. Renal physiology 2010;298(5):F1113-7.
2010: anand rotte; Venkanna Pasham; madhuri bhandaru; Melanie Eichenmüller; Wenting Yang; Syed M Qadri; Daniela S Kempe; Goverdhan Puchchakayala; David Pearce; Morris J Birnbaum; Florian Lang
Regulation of gastric acid secretion by PKB/Akt2.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(6):695-704.
2009: Theodora M Mauro; James McCormick; Jian Wang; Krishna M Boini; Leena Ray; Bobby Monks; Morris J Birnbaum; Florian Lang; David Pearce
Akt2 and SGK3 are both determinants of postnatal hair follicle development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(9):3193-202.
2009: Rama Soundararajan; Daniël Melters; I-Chia Shih; Jian Wang; David Pearce
Epithelial sodium channel regulated by differential composition of a signaling complex.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7804-9.
2007: Rama Soundararajan; Jian Wang; Daniël Melters; David Pearce
Differential activities of glucocorticoid-induced leucine zipper protein isoforms.
The Journal of biological chemistry 2007;282(50):36303-13.
2007: Alan C Pao; James McCormick; Hongyan Li; John Siu; Cedric Govaerts; Vivek Bhalla; Rama Soundararajan; David Pearce
NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions.
American journal of physiology. Renal physiology 2007;292(6):F1741-50.
2007: David Pearce; Thomas R Kleyman
Salt, sodium channels, and SGK1.
The Journal of clinical investigation 2007;117(3):592-5.
2006: Vivek Bhalla; Rama Soundararajan; Alan C Pao; Hongyan Li; David Pearce
Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.
American journal of physiology. Renal physiology 2006;291(4):F714-21.
2006: Vivek Bhalla; Nicholas M Oyster; Adam C Fitch; Marjolein A Wijngaarden; Dietbert Neumann; Uwe Schlattner; David Pearce; Kenneth R Hallows
AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.
The Journal of biological chemistry 2006;281(36):26159-69.
2006: Florian Grahammer; Ferruh Artunc; Diana Sandulache; Rexhep Rexhepaj; Björn Friedrich; Teut Risler; James McCormick; Kevin Dawson; Jian Wang; David Pearce; Peer Wulff; Dietmar Kuhl; Florian Lang
Renal function of gene-targeted mice lacking both SGK1 and SGK3.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(4):R945-50.
2006: Undine E Lang; David P Wolfer; Florian Grahammer; Nathalie Strutz-Seebohm; Guiscard Seebohm; Hans-Peter Lipp; James McCormick; Rainer Hellweg; Kevin Dawson; Jian Wang; David Pearce; Florian Lang
Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse.
Behavioural brain research 2006;167(1):75-86.
2005: Rama Soundararajan; Ting Ting Zhang; Jian Wang; Alain Vandewalle; David Pearce
A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport.
The Journal of biological chemistry 2005;280(48):39970-81.
2005: Vivek Bhalla; Dorothée Daidié; Hongyan Li; Alan C Pao; Lila P LaGrange; Jian Wang; Alain Vandewalle; James Stockand; Olivier Staub; David Pearce
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3073-84.
2005: Ciprian D Sandu; Rexhep Rexhepaj; Florian Grahammer; James McCormick; Guido Henke; Monica Palmada; Srinivas Nammi; Undine Lang; Marco Metzger; Lothar Just; Thomas Skutella; Kevin Dawson; Jian Wang; David Pearce; Florian Lang
Decreased intestinal glucose transport in the sgk3-knockout mouse.
Pflügers Archiv : European journal of physiology 2005;451(3):437-44.
2005: Nathalie Strutz-Seebohm; Guiscard Seebohm; Andreas F Mack; Hans-Joachim Wagner; Lothar Just; Thomas Skutella; Undine E Lang; Guido Henke; Marion Striegel; Michael Hollmann; Nathalie Rouach; Roger A Nicoll; James McCormick; Jian Wang; David Pearce; Florian Lang
Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3.
The Journal of physiology 2005;565(Pt 2):381-90.
2005: James McCormick; Vivek Bhalla; Alan C Pao; David Pearce
SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.
Physiology (Bethesda, Md.) 2005;20():134-9.
2004: James McCormick; Yuxi Feng; Kevin Dawson; Martin J Behne; Benjamin Yu; Jian Wang; Amanda Wyatt; Guido Henke; Florian Grahammer; Theodora M Mauro; Florian Lang; David Pearce
Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.
Molecular biology of the cell 2004;15(9):4278-88.
2004: Aditi Bhargava; Mary F Dallman; David Pearce; SuJean Choi
Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides.
Brain research. Brain research protocols 2004;13(2):115-25.
2004: Aditi Bhargava; David Pearce
Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products.
Trends in endocrinology and metabolism: TEM 2004;15(4):147-53.
2004: Songcang Chen; James McCormick; Kavitha Prabaker; Jian Wang; David Pearce; David G Gardner
Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.
Hypertension 2004;43(4):866-71.
2003: Melanie Adams; Onno C Meijer; Jian Wang; Aditi Bhargava; David Pearce
Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2583-92.
2003: Björn Friedrich; Yuxi Feng; P Cohen; Teut Risler; A Vandewalle; Stefan Broer; Jian Wang; David Pearce; Florian Lang
The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.
Pflügers Archiv : European journal of physiology 2003;445(6):693-6.
2003: David Pearce; Aditi Bhargava; Timothy J Cole
Aldosterone: its receptor, target genes, and actions.
Vitamins and hormones 2003;66():29-76.
2003: David Pearce
SGK1 regulation of epithelial sodium transport.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2003;13(1):13-20.
2002: C Chris Yun; Monica Palmada; Hamdy M Embark; Olga Fedorenko; Yuxi Feng; Guido Henke; Iwan Setiawan; Christoph Boehmer; Edward J Weinman; Sabrina Sandrasagra; Christoph Korbmacher; Philip Cohen; David Pearce; Florian Lang
The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.
Journal of the American Society of Nephrology : JASN 2002;13(12):2823-30.
2002: Aditi Bhargava; Robert S Mathias; James McCormick; Mary F Dallman; David Pearce
Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1629-37.
2002: David J Rozansky; Jian Wang; Ninh Doan; Timothy Purdy; Tonya Faulk; Aditi Bhargava; Kevin Dawson; David Pearce
Hypotonic induction of SGK1 and Na+ transport in A6 cells.
American journal of physiology. Renal physiology 2002;283(1):F105-13.
2002: David Pearce; Anikó Náray-Fejes-Tóth; Géza Fejes-Tóth
Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors.
The Journal of biological chemistry 2002;277(2):1451-6.
2001: David Pearce
The role of SGK1 in hormone-regulated sodium transport.
Trends in endocrinology and metabolism: TEM 2001;12(8):341-7.
2001: Johannes Loffing; Marija Zecevic; Eric Féraille; Brigitte Kaissling; C Asher; Bernard C Rossier; G L Firestone; David Pearce; François Verrey
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
American journal of physiology. Renal physiology 2001;280(4):F675-82.
2001: Jian Wang; Pascal Barbry; Anita C Maiyar; David J Rozansky; Aditi Bhargava; Meredith L L Leong; Gary L Firestone; David Pearce
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.
American journal of physiology. Renal physiology 2001;280(2):F303-13.
2000: Michael P Sherman; Carlos M C De Noronha; David Pearce; Warner Greene
Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.
Journal of virology 2000;74(17):8159-65.
2000: Aditi Bhargava; Onno C Meijer; Mary F Dallman; David Pearce
Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3129-38.
2000: David Pearce; François Verrey; S Y Chen; L Mastroberardino; O C Meijer; Jian Wang; Aditi Bhargava
Role of SGK in mineralocorticoid-regulated sodium transport.
Kidney international 2000;57(4):1283-9.
2000: François Verrey; David Pearce; R Pfeiffer; B Spindler; L Mastroberardino; Vanessa Summa; Marija Zecevic
Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms.
Kidney international 2000;57(4):1277-82.
2000: Onno C Meijer; A Williamson; Mary F Dallman; David Pearce
Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.
Journal of neuroendocrinology 2000;12(3):245-54.
1999: S Y Chen; Aditi Bhargava; L Mastroberardino; O C Meijer; Jian Wang; Patricia Buse; Gary L Firestone; François Verrey; David Pearce
Epithelial sodium channel regulated by aldosterone-induced protein sgk.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2514-9.
1998: David Pearce; William Matsui; J N Miner; Keith R Yamamoto
Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites.
The Journal of biological chemistry 1998;273(46):30081-5.
1998: Géza Fejes-Tóth; David Pearce; Anikó Náray-Fejes-Tóth
Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):2973-8.
1997: S y Chen; Jian Wang; G q Yu; Weihong Liu; David Pearce
Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity.
The Journal of biological chemistry 1997;272(22):14087-92.