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David Pearce

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Kielar Catherine; Wishart Thomas M; Palmer Alice; Dihanich Sybille; Wong Andrew M; Macauley Shannon L; Chan Chun-Hung; Sands Mark S; Pearce David A; Cooper Jonathan D; Gillingwater Thomas H
Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease.
Bozorg Sara; Ramirez-Montealegre Denia; Chung Mina; Pearce David A
Juvenile neuronal ceroid lipofuscinosis (JNCL) and the eye.
Benedict Jared W; Getty Amanda L; Wishart Thomas M; Gillingwater Thomas H; Pearce David A
Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2.

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All Publications

2009: Kielar Catherine; Wishart Thomas M; Palmer Alice; Dihanich Sybille; Wong Andrew M; Macauley Shannon L; Chan Chun-Hung; Sands Mark S; Pearce David A; Cooper Jonathan D; Gillingwater Thomas H
Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease.
Human molecular genetics 2009;18(21):4066-80.
2009: Bozorg Sara; Ramirez-Montealegre Denia; Chung Mina; Pearce David A
Juvenile neuronal ceroid lipofuscinosis (JNCL) and the eye.
Survey of ophthalmology 2009;54(4):463-71.
2009: Benedict Jared W; Getty Amanda L; Wishart Thomas M; Gillingwater Thomas H; Pearce David A
Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2.
Journal of neuroscience research 2009;87(9):2157-66.
2009: Schmidt Karyn; Wolfe Devin M; Stiller Barbara; Pearce David A
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2.
Biochemical and biophysical research communications 2009;383(2):198-202.
2009: Seehafer Sabrina S; Pearce David A
Spectral properties and mechanisms that underlie autofluorescent accumulations in Batten disease.
Biochemical and biophysical research communications 2009;382(2):247-51.
2009: Chan C-H; Ramirez-Montealegre D; Pearce D A
Altered arginine metabolism in the central nervous system (CNS) of the Cln3-/- mouse model of juvenile Batten disease.
Neuropathology and applied neurobiology 2009;35(2):189-207.
2009: Weimer Jill M; Benedict Jared W; Getty Amanda L; Pontikis Charlie C; Lim Ming J; Cooper Jonathan D; Pearce David A
Cerebellar defects in a mouse model of juvenile neuronal ceroid lipofuscinosis.
Brain research 2009;1266():93-107.
2008: Chan Chun-Hung; Mitchison Hannah M; Pearce David A
Transcript and in silico analysis of CLN3 in juvenile neuronal ceroid lipofuscinosis and associated mouse models.
Human molecular genetics 2008;17(21):3332-9.
2008: Muzaffar Neda E; Pearce David A
Analysis of NCL Proteins from an Evolutionary Standpoint.
Current genomics 2008;9(2):115-36.
2008: Castaneda Julian A; Lim Ming J; Cooper Jonathan D; Pearce David A
Immune system irregularities in lysosomal storage disorders.
Acta neuropathologica 2008;115(2):159-74.
2008: Kovács Attila D; Pearce David A
Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease.
Experimental neurology 2008;209(1):288-91.
2008: Castaneda Julian A; Pearce David A
Identification of alpha-fetoprotein as an autoantigen in juvenile Batten disease.
Neurobiology of disease 2008;29(1):92-102.
2007: Benedict Jared W; Sommers Crosby A; Pearce David A
Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease.
Journal of neuroscience research 2007;85(13):2882-91.
2007: Ramirez-Montealegre Denia; Pearce David A
Imaging of late infantile neuronal ceroid lipofuscinosis: a clinical rating scale.
Neurology 2007;69(6):503-4.
2007: Weimer Jill M; Benedict Jared W; Elshatory Yasser M; Short Douglas W; Ramirez-Montealegre Denia; Ryan Deborah A; Alexander Noreen A; Federoff Howard J; Cooper Jonathan D; Pearce David A
Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis.
Brain research 2007;1162():98-112.
2007: Adams Heather R; Kwon Jennifer; Marshall Frederick J; de Blieck Elisabeth A; Pearce David A; Mink Jonathan W
Neuropsychological symptoms of juvenile-onset batten disease: experiences from 2 studies.
Journal of child neurology 2007;22(5):621-7.
2007: Vitiello Seasson Phillips; Wolfe Devin M; Pearce David A
Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells.
Human molecular genetics 2007;16(9):1007-16.
2007: Lim Ming J; Alexander Noreen; Benedict Jared W; Chattopadhyay Subrata; Shemilt Stephen J A; Guérin Christopher J; Cooper Jonathan D; Pearce David A
IgG entry and deposition are components of the neuroimmune response in Batten disease.
Neurobiology of disease 2007;25(2):239-51.
2006: Phillips Seasson N; Muzaffar Neda; Codlin Sandra; Korey Christopher A; Taschner Peter E M; de Voer Gert; Mole Sara E; Pearce David A
Characterizing pathogenic processes in Batten disease: use of small eukaryotic model systems.
Biochimica et biophysica acta 2006;1762(10):906-19.
2006: Lim M J; Beake J; Bible E; Curran T M; Ramirez-Montealegre D; Pearce D A; Cooper J D
Distinct patterns of serum immunoreactivity as evidence for multiple brain-directed autoantibodies in juvenile neuronal ceroid lipofuscinosis.
Neuropathology and applied neurobiology 2006;32(5):469-82.
2006: Leman Adam R; Polochock Susan; Mole Sara E; Pearce David A; Rothberg Paul G
Homogeneous PCR nucleobase quenching assays to detect four mutations that cause neuronal ceroid lipofuscinosis: T75P and R151X in CLN1, and IVS5-1G>C and R208X in CLN2.
Journal of neuroscience methods 2006;157(1):124-31.
2006: Ramirez-Montealegre Denia; Rothberg Paul G; Pearce David A
Another disorder finds its gene.
Brain : a journal of neurology 2006;129(Pt 6):1353-6.
2006: Kovács Attila D; Weimer Jill M; Pearce David A
Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease.
Neurobiology of disease 2006;22(3):575-85.
2006: Weimer Jill M; Custer Andrew W; Benedict Jared W; Alexander Noreen A; Kingsley Evan; Federoff Howard J; Cooper Jonathan D; Pearce David A
Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons.
Neurobiology of disease 2006;22(2):284-93.
2006: Adams Heather; de Blieck Elisabeth A; Mink Jonathan W; Marshall Frederick J; Kwon Jennifer; Dure Leon; Rothberg Paul G; Ramirez-Montealegre Denia; Pearce David A
Standardized assessment of behavior and adaptive living skills in juvenile neuronal ceroid lipofuscinosis.
Developmental medicine and child neurology 2006;48(4):259-64.
2006: Seehafer Sabrina S; Pearce David A
You say lipofuscin, we say ceroid: defining autofluorescent storage material.
Neurobiology of aging 2006;27(4):576-88.
2006: Padilla-López Sergio; Pearce David A
Saccharomyces cerevisiae lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuole.
The Journal of biological chemistry 2006;281(15):10273-80.
2006: Wolfe Devin M; Pearce David A
Channeling studies in yeast: yeast as a model for channelopathies?
Neuromolecular medicine 2006;8(3):279-306.
2005: Ramirez-Montealegre Denia; Pearce David A
Defective lysosomal arginine transport in juvenile Batten disease.
Human molecular genetics 2005;14(23):3759-73.
2005: Kwon Jennifer M; Rothberg Paul G; Leman Adam R; Weimer Jill M; Mink Jonathan W; Pearce David A
Novel CLN3 mutation predicted to cause complete loss of protein function does not modify the classical JNCL phenotype.
Neuroscience letters 2005;387(2):111-4.
2005: Moosvi S Azra; McDonald Ian R; Pearce David A; Kelly Donovan P; Wood Ann P
Molecular detection and isolation from antarctica of methylotrophic bacteria able to grow with methylated sulfur compounds.
Systematic and applied microbiology 2005;28(6):541-54.
2005: Marshall F J; de Blieck E A; Mink J W; Dure L; Adams H; Messing S; Rothberg P G; Levy E; McDonough T; DeYoung J; Wang M; Ramirez-Montealegre D; Kwon J M; Pearce D A
A clinical rating scale for Batten disease: reliable and relevant for clinical trials.
Neurology 2005;65(2):275-9.
2005: Cho Steve K; Gao Ningguo; Pearce David A; Lehrman Mark A; Hofmann Sandra L
Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.
Glycobiology 2005;15(6):637-48.
2005: Leman A R; Pearce D A; Rothberg P G
Gene symbol: CLN3. Disease: Juvenile neuronal ceroid lipofuscinosis (Batten disease).
Human genetics 2005;116(6):544.
2005: Weimer Jill M; Chattopadhyay Subrata; Custer Andrew W; Pearce David A
Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1.
Biochemical and biophysical research communications 2005;330(4):1176-81.
2005: Phillips Seasson N; Benedict Jared W; Weimer Jill M; Pearce David A
CLN3, the protein associated with batten disease: structure, function and localization.
Journal of neuroscience research 2005;79(5):573-83.
2005: Leman A R; Pearce D A; Rothberg P G
Gene symbol: CLN3. Disease: juvenile neuronal ceroid lipofuscinosis (Batten disease).
Human genetics 2005;116(3):236.
2005: Ramirez-Montealegre D; Chattopadhyay S; Curran T M; Wasserfall C; Pritchard L; Schatz D; Petitto J; Hopkins D; She J-X; Rothberg P G; Atkinson M; Pearce D A
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Neurology 2005;64(4):743-5.
2005: Kim Yoojin; Chattopadhyay Subrata; Locke Sarahjane; Pearce David A
Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae.
Eukaryotic cell 2005;4(2):281-8.
2005: Chen Xi; Moerschell Richard P; Pearce David A; Ramanan Durga D; Sherman Fred
Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures.
Current genetics 2005;47(2):67-83.
2005: Moosvi S Azra; Pacheco Catarina C; McDonald Ian R; De Marco Paolo; Pearce David A; Kelly Donovan P; Wood Ann P
Isolation and properties of methanesulfonate-degrading Afipia felis from Antarctica and comparison with other strains of A. felis.
Environmental microbiology 2005;7(1):22-33.
2004: Pearce David A; Atkinson Mark; Tagle Danilo A
Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.
Neurology 2004;63(11):2001-5.
2004: Pontikis Charlie C; Cella Claire V; Parihar Nisha; Lim Ming J; Chakrabarti Shubhodeep; Mitchison Hannah M; Mobley William C; Rezaie Payam; Pearce David A; Cooper Jonathan D
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.
Brain research 2004;1023(2):231-42.
2004: Chattopadhyay Subrata; Kingsley Evan; Serour Andrew; Curran Timothy M; Brooks Andrew I; Pearce David A
Altered gene expression in the eye of a mouse model for batten disease.
Investigative ophthalmology & visual science 2004;45(9):2893-905.
2004: Rothberg Paul G; Ramirez-Montealegre Denia; Frazier Sharon D; Pearce David A
Homogeneous polymerase chain reaction nucleobase quenching assay to detect the 1-kbp deletion in CLN3 that causes Batten disease.
The Journal of molecular diagnostics : JMD 2004;6(3):260-3.
2003: Kim Yoojin; Ramirez-Montealegre Denia; Pearce David A
A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15458-62.
2003: Pearce David A; McCall Karin; Mooney Robert A; Chattopadhyay Subrata; Curran Timothy M
Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses.
Clinica chimica acta; international journal of clinical chemistry 2003;332(1-2):145-8.
2003: Elshatory Yasser; Brooks Andrew I; Chattopadhyay Subrata; Curran Timothy M; Gupta Praveena; Ramalingam Vijay; Hofmann Sandra L; Pearce David A
Early changes in gene expression in two models of Batten disease.
FEBS letters 2003;538(1-3):207-12.
2003: Chattopadhyay Subrata; Roberts Paul M; Pearce David A
The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p.
Biochemical and biophysical research communications 2003;302(3):534-8.
2003: Brooks Andrew I; Chattopadhyay Subrata; Mitchison Hannah M; Nussbaum Robert L; Pearce David A
Functional categorization of gene expression changes in the cerebellum of a Cln3-knockout mouse model for Batten disease.
Molecular genetics and metabolism 2003;78(1):17-30.
2003: Bijlani Rahul; Cheng Yinhe; Pearce David A; Brooks Andrew I; Ogihara Mitsunori
Prediction of biologically significant components from microarray data: Independently Consistent Expression Discriminator (ICED).
Bioinformatics (Oxford, England) 2003;19(1):62-70.
2002: Chattopadhyay Subrata; Kriscenski-Perry Elizabeth; Wenger David A; Pearce David A
An autoantibody to GAD65 in sera of patients with juvenile neuronal ceroid lipofuscinoses.
Neurology 2002;59(11):1816-7.
2002: Kriscenski-Perry Elizabeth; Applegate Craig D; Serour Andrew; Mhyre Timothy R; Leonardo Christopher C; Pearce David A
Altered flurothyl seizure induction latency, phenotype, and subsequent mortality in a mouse model of juvenile neuronal ceroid lipofuscinosis/batten disease.
Epilepsia 2002;43(10):1137-40.
2002: Chattopadhyay Subrata; Pearce David A
Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae.
Eukaryotic cell 2002;1(4):606-12.
2002: Chattopadhyay Subrata; Ito Masumi; Cooper Jonathan D; Brooks Andrew I; Curran Timothy M; Powers James M; Pearce David A
An autoantibody inhibitory to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.
Human molecular genetics 2002;11(12):1421-31.
2002: Weimer Jill M; Kriscenski-Perry Elizabeth; Elshatory Yasser; Pearce David A
The neuronal ceroid lipofuscinoses: mutations in different proteins result in similar disease.
Neuromolecular medicine 2002;1(2):111-24.
2001: Sánchez N S; Pearce D A; Cardillo T S; Uribe S; Sherman F
Requirements of Cyc2p and the porin, Por1p, for ionic stability and mitochondrial integrity in Saccharomyces cerevisiae.
Archives of biochemistry and biophysics 2001;392(2):326-32.
2001: Cottone C D; Chattopadhyay S; Pearce D A
Searching for interacting partners of CLN1, CLN2 and Btn1p with the two-hybrid system.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2001;5 Suppl A():95-8.
2001: Pearce D A
Experimental models of NCL: the yeast model.
Advances in genetics 2001;45():205-16.
2000: Chattopadhyay S; Muzaffar N E; Sherman F; Pearce D A
The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.
Journal of bacteriology 2000;182(22):6418-23.
2000: Chattopadhyay S; Pearce D A
Neural and extraneural expression of the neuronal ceroid lipofuscinoses genes CLN1, CLN2, and CLN3: functional implications for CLN3.
Molecular genetics and metabolism 2000;71(1-2):207-11.
2000: Pearce D A
Localization and processing of CLN3, the protein associated to Batten disease: where is it and what does it do?
Journal of neuroscience research 2000;59(1):19-23.
1999: Pearce D A; Carr C J; Das B; Sherman F
Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11341-5.
1999: Pearce D A; Sherman F
Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae.
Journal of bacteriology 1999;181(16):4774-9.
1999: Pearce D A
Hereditary spastic paraplegia: mitochondrial metalloproteases of yeast.
Human genetics 1999;104(6):443-8.
1999: Pearce D A; Ferea T; Nosel S A; Das B; Sherman F
Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.
Nature genetics 1999;22(1):55-8.
1999: Pearce D A; Nosel S A; Sherman F
Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p.
Molecular genetics and metabolism 1999;66(4):320-3.
1999: Pearce D A; Sherman F
Investigation of Batten disease with the yeast Saccharomyces cerevisiae.
Molecular genetics and metabolism 1999;66(4):314-9.
1998: Pearce D A; Cardillo T S; Sherman F
Cyc2p is required for maintaining ionic stability and efficient cytochrome c import and mitochondrial function in Saccharomyces cerevisiae.
FEBS letters 1998;439(3):307-11.
1998: Pearce D A; Sherman F
A yeast model for the study of Batten disease.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6915-8.
1998: Pearce D A; Sherman F
Degradation of yeast cytochromes c dependent and independent on its physiological partners.
Archives of biochemistry and biophysics 1998;352(1):85-96.
1997: Pearce D A; Sherman F
Differential ubiquitin-dependent degradation of the yeast apo-cytochrome c isozymes.
The Journal of biological chemistry 1997;272(50):31829-36.
1997: Pearce D A; Sherman F
BTN1, a yeast gene corresponding to the human gene responsible for Batten's disease, is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase.
Yeast (Chichester, England) 1997;13(8):691-7.
1995: Pearce D A; Sherman F
Enhanced stability in vivo of a thermodynamically stable mutant form of yeast iso-1-cytochrome c.
Molecular & general genetics : MGG 1995;249(2):155-61.
1995: Pearce D A; Sherman F
Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1.
The Journal of biological chemistry 1995;270(36):20879-82.
1995: Pearce D A; Sherman F
Diminished degradation of yeast cytochrome c by interactions with its physiological partners.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3735-9.

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David Pearce

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