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Edward Pearce

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Schistosomiasis mansoni

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Erika L Pearce; Edward J Pearce
Metabolic pathways in immune cell activation and quiescence.
David Artis; Edward J Pearce
Special issue: translatability of helminth therapy.
Georgia Perona-Wright; Haozhong Situ; David L Woodland; Edward J Pearce; Elizabeth Bassity; Tres Cookenham; Tori C Freitas; Jacob E Kohlmeier; Katja Mohrs; Markus Mohrs
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.

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All Publications

2013: Erika L Pearce; Edward J Pearce
Metabolic pathways in immune cell activation and quiescence.
Immunity 2013;38(4):633-43.
2013: David Artis; Edward J Pearce
Special issue: translatability of helminth therapy.
International journal for parasitology 2013;43(3-4):189.
2012: Georgia Perona-Wright; Haozhong Situ; David L Woodland; Edward J Pearce; Elizabeth Bassity; Tres Cookenham; Tori C Freitas; Jacob E Kohlmeier; Katja Mohrs; Markus Mohrs
Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18535-40.
2012: Keke Fairfax; Stanley Ching-Cheng Huang; Marcia Nascimento; Bart Everts; Edward J Pearce
Th2 responses in schistosomiasis.
Seminars in immunopathology 2012;34(6):863-71.
2012: Eyal Amiel; Jonathan D Curtis; Bart Everts; Tori C Freitas; Irah L King; Erika L Pearce; Edward J Pearce
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2151-8.
2012: Bart Everts; Tori C Freitas; Eyal Amiel; Robert Chott; Erika L Pearce; Gerritje J W van der Windt; Kevin E Yarasheski; Edward J Pearce
Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.
Blood 2012;120(7):1422-31.
2012: Gerritje J W van der Windt; Eyal Amiel; Chih-Hao Chang; Jonathan D Curtis; Bart Everts; Tori C Freitas; Edward J Pearce; Erika L Pearce
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development.
Immunity 2012;36(1):68-78.
2012: Stanley Ching-Cheng Huang; James B Lok; Eyal Amiel; Bart Everts; Tori C Freitas; Erika L Pearce; Edward J Pearce
Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni.
PLoS pathogens 2012;8(10):e1002996.
2012: Hongguang Shao; Xinshe Li; Holman C Massey; Thomas Nolan; Edward J Pearce; James B Lok
Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines.
PLoS pathogens 2012;8(8):e1002871.
2012: Sarah E Galanti; Stanley Ching-Cheng Huang; Edward J Pearce
Cell death and reproductive regression in female Schistosoma mansoni.
PLoS neglected tropical diseases 2012;6(2):e1509.
2012: Keke C Fairfax; Tori C Freitas; Irah L King; Markus Mohrs; Eyal Amiel; Edward J Pearce
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.
PLoS pathogens 2012;8(1):e1002490.
2011: Xinshe Li; Ariel Junio; Holman C Massey; Thomas Nolan; Edward J Pearce; Hongguang Shao; Mark E Viney; James B Lok
Transgenesis in the parasitic nematode Strongyloides ratti.
Molecular and biochemical parasitology 2011;179(2):114-9.
2010: Connie M Krawczyk; Thomas Holowka; Jie Sun; Julianna Blagih; Eyal Amiel; Ralph J DeBerardinis; Justin R Cross; Euihye Jung; Craig Thompson; Russell G Jones; Edward J Pearce
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.
Blood 2010;115(23):4742-9.
2010: Tori C Freitas; Edward J Pearce
Growth factors and chemotactic factors from parasitic helminths: molecular evidence for roles in host-parasite interactions versus parasite development.
International journal for parasitology 2010;40(7):761-73.
2010: Mai H Tran; Tori C Freitas; Leanne Cooper; Soraya Gaze; Michelle L Gatton; Malcolm K Jones; Erica Lovas; Edward J Pearce; Alex Loukas
Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover.
PLoS pathogens 2010;6(4):e1000840.
2009: Rick M Maizels; Edward J Pearce; David Artis; Maria Yazdanbakhsh; Thomas A Wynn
Regulation of pathogenesis and immunity in helminth infections.
The Journal of experimental medicine 2009;206(10):2059-66.
2009: Jacqueline G Perrigoue; Steven A Saenz; Mark C Siracusa; Eric J Allenspach; Betsy C Taylor; Paul R Giacomin; Meera G Nair; Yurong Du; Colby Zaph; Nico van Rooijen; Michael R Comeau; Edward J Pearce; Tom Li Stephen; David Artis
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Nature immunology 2009;10(7):697-705.
2009: Arielle Glatman Zaretsky; Justin J Taylor; Irah L King; Fraser A Marshall; Markus Mohrs; Edward J Pearce
T follicular helper cells differentiate from Th2 cells in response to helminth antigens.
The Journal of experimental medicine 2009;206(5):991-9.
2009: Meera G Nair; Yurong Du; Jacqueline G Perrigoue; Colby Zaph; Justin J Taylor; Michael H Goldschmidt; Gary P Swain; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Margaret Karow; Sean Stevens; Edward J Pearce; David Artis
Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.
The Journal of experimental medicine 2009;206(4):937-52.
2009: Tori C Freitas; Euihye Jung; Edward J Pearce
A bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoni.
International journal for parasitology 2009;39(3):281-7.
2009: Lucas Carvalho; Jie Sun; Colleen Kane; Fraser Marshall; Connie Krawczyk; Edward J Pearce
Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function.
Immunology 2009;126(1):28-34.
2008: Fraser A Marshall; Edward J Pearce
Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7562-70.
2008: Colleen M Kane; Euihye Jung; Edward J Pearce
Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88.
Infection and immunity 2008;76(12):5754-9.
2008: Georgia Perona-Wright; Katja Mohrs; Justin Taylor; Colby Zaph; David Artis; Edward J Pearce; Markus Mohrs
Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6697-701.
2008: Lucas P Carvalho; Edward J Pearce; Phillip Scott
Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6473-80.
2008: Connie M Krawczyk; Jie Sun; Edward J Pearce
Th2 differentiation is unaffected by Jagged2 expression on dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7931-7.
2008: Edward J Pearce; Tori C Freitas
Reverse genetics and the study of the immune response to schistosomes.
Parasite immunology 2008;30(4):215-21.
2008: Jie Sun; Connie J Krawczyk; Edward J Pearce
Suppression of Th2 cell development by Notch ligands Delta1 and Delta4.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1655-61.
2007: Edward J Pearce
Worms tame mast cells.
Nature medicine 2007;13(11):1288-9.
2007: Maria E Morales; Victoria H Mann; Kristine J Kines; Geoffrey N Gobert; Malcolm J Fraser; Bernd H Kalinna; Jason M Correnti; Edward J Pearce; Paul J Brindley
piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(13):3479-89.
2007: Edward J Pearce; Louis Schofield
Host-pathogen interactions: pas de deux.
Current opinion in immunology 2007;19(4):373-5.
2007: Jason M Correnti; Euihye Jung; Tori C Freitas; Edward J Pearce
Transfection of Schistosoma mansoni by electroporation and the description of a new promoter sequence for transgene expression.
International journal for parasitology 2007;37(10):1107-15.
2007: Connie M Krawczyk; Hao Shen; Edward J Pearce
Memory CD4 T cells enhance primary CD8 T-cell responses.
Infection and immunity 2007;75(7):3556-60.
2007: Gabriele Schramm; Katja Mohrs; Maren Wodrich; Michael J Doenhoff; Edward J Pearce; Helmut Haas; Markus Mohrs
Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6023-7.
2007: Melinda J Ekkens; Devon Shedlock; Euihye Jung; Amy E Troy; Erika L Pearce; Hao Shen; Edward J Pearce
Th1 and Th2 cells help CD8 T-cell responses.
Infection and immunity 2007;75(5):2291-6.
2007: Tori C Freitas; Euihye Jung; Edward J Pearce
TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni.
PLoS pathogens 2007;3(4):e52.
2007: Connie M Krawczyk; Hao Shen; Edward J Pearce
Functional plasticity in memory T helper cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4080-8.
2007: Paul J Brindley; Edward J Pearce
Genetic manipulation of schistosomes.
International journal for parasitology 2007;37(5):465-73.
2007: Jacqueline G Perrigoue; Ji Li; Colby Zaph; Michael H Goldschmidt; Phillip Scott; Frederic J de Sauvage; Edward J Pearce; Nico Ghilardi; David Artis
IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.
The Journal of experimental medicine 2007;204(3):481-7.
2007: Jie Sun; Edward J Pearce
Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1635-44.
2006: Georgia Perona-Wright; Stephen J Jenkins; alison crawford; David Gray; Edward J Pearce; Andrew S MacDonald
Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo.
European journal of immunology 2006;36(9):2367-75.
2006: Justin J Taylor; Markus Mohrs; Edward J Pearce
Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5839-47.
2006: Edward J Pearce; Colleen M Kane; Jie Sun
Regulation of dendritic cell function by pathogen-derived molecules plays a key role in dictating the outcome of the adaptive immune response.
Chemical immunology and allergy 2006;90():82-90.
2005: Jason M Correnti; Paul J Brindley; Edward J Pearce
Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth.
Molecular and biochemical parasitology 2005;143(2):209-15.
2005: Edward J Pearce
Priming of the immune response by schistosome eggs.
Parasite immunology 2005;27(7-8):265-70.
2005: David Artis; Colleen M Kane; James Fiore; Colby Zaph; Sagi Shapira; Karen Joyce; Andrew Macdonald; Christopher Hunter; Phillip Scott; Edward J Pearce
Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7154-9.
2005: Jie Sun; Matthew Walsh; Alejandro V Villarino; Laura Cervi; Christopher A Hunter; Yongwon Choi; Edward J Pearce
TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):742-51.
2004: Colleen M Kane; Laura Cervi; Jie Sun; Amy S McKee; Katherine S Masek; Sagi Shapira; Christopher A Hunter; Edward J Pearce
Helminth antigens modulate TLR-initiated dendritic cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7454-61.
2004: Edward J Pearce; Colleen M Kane; Jie Sun; Justin J Taylor; Amy S McKee; Laura Cervi
Th2 response polarization during infection with the helminth parasite Schistosoma mansoni.
Immunological reviews 2004;201():117-26.
2004: Jason M Correnti; Edward J Pearce
Transgene expression in Schistosoma mansoni: introduction of RNA into schistosomula by electroporation.
Molecular and biochemical parasitology 2004;137(1):75-9.
2004: Amy S McKee; Florence Dzierszinski; Marianne Boes; David S Roos; Edward J Pearce
Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2632-40.
2004: Sean G Forrester; Paul W Warfel; Edward J Pearce
Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoni.
Molecular and biochemical parasitology 2004;136(2):149-56.
2004: Amy S McKee; Edward J Pearce
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):1224-31.
2004: Laura Cervi; Andrew S MacDonald; Colleen Kane; Florence Dzierszinski; Edward J Pearce
Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2016-20.
2003: Erinn B Rankin; Duonan Yu; Jiu Jiang; Hao Shen; Edward J Pearce; Michael H Goldschmidt; David E Levy; Tatyana V Golovkina; Christopher A Hunter; Andrei Thomas-Tikhonenko
An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth.
Cancer biology & therapy 2003;2(6):687-93.
2003: Edward J Pearce
Progress towards a vaccine for schistosomiasis.
Acta tropica 2003;86(2-3):309-13.
2003: Amy D Straw; Andrew S MacDonald; Eric Y Denkers; Edward J Pearce
CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):727-34.
2003: Anne Camille La Flamme; Andrew S MacDonald; Clive R Huxtable; Michael Carroll; Edward J Pearce
Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):470-6.
2002: Anne Camille La Flamme; Phillip Scott; Edward J Pearce
Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages.
Parasite immunology 2002;24(7):339-45.
2002: Edward J Pearce; Andrew S MacDonald
The immunobiology of schistosomiasis.
Nature reviews. Immunology 2002;2(7):499-511.
2002: Sharon McGonigle; Maria Loschiavo; Edward J Pearce
14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform.
International journal for parasitology 2002;32(6):685-93.
2002: Andrew S MacDonald; Elisabeth A Patton; Anne Camille La Flamme; Maria Ilma Araujo; Clive R Huxtable; Beverley E Bauman; Edward J Pearce
Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4643-9.
2002: Andrew S MacDonald; Edward J Pearce
Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3127-30.
2002: Melissa J Beall; Edward J Pearce
Transforming growth factor-beta and insulin-like signalling pathways in parasitic helminths.
International journal for parasitology 2002;32(4):399-404.
2002: Andrew S MacDonald; Maria Ilma Araujo; Edward J Pearce
Immunology of parasitic helminth infections.
Infection and immunity 2002;70(2):427-33.
2002: Sharon McGonigle; Melissa J Beall; Edward J Pearce
Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response.
Biochemistry 2002;41(2):579-87.
2002: Andrew S MacDonald; Amy D Straw; Nicole M Dalton; Edward J Pearce
Cutting edge: Th2 response induction by dendritic cells: a role for CD40.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):537-40.
2002: Elisabeth A Patton; Anne Camille La Flamme; Joao A Pedras-Vasoncelos; Edward J Pearce
Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis.
Infection and immunity 2002;70(1):177-84.
2001: M Hesse; Manuel Modolell; Anne Camille La Flamme; M Schito; Jose M. Fuentes; Allen W Cheever; Edward J Pearce; Thomas A Wynn
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6533-44.
2001: Anne Camille La Flamme; Elisabeth A Patton; Edward J Pearce
Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice.
Infection and immunity 2001;69(12):7445-52.
2001: JA Pedras-Vasconcelos; LR Brunet; Edward J Pearce
Profound effect of the absence of IL-4 on T cell responses during infection with Schistosoma mansoni.
Journal of leukocyte biology 2001;70(5):737-44.
2001: Melissa J Beall; Edward J Pearce
Human transforming growth factor-beta activates a receptor serine/threonine kinase from the intravascular parasite Schistosoma mansoni.
The Journal of biological chemistry 2001;276(34):31613-9.
2001: Andrew S MacDonald; Amy D Straw; Beverley E Bauman; Edward J Pearce
CD8- dendritic cell activation status plays an integral role in influencing Th2 response development.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1982-8.
2001: Sharon McGonigle; E L Feeney; Melissa J Beall; Edward J Pearce
SIP, a novel SH3 domain-containing protein, interacts with Schistosoma mansoni receptor kinase 1.
Molecular and biochemical parasitology 2001;114(1):119-23.
2001: Maria Ilma Araujo; Susan K Bliss; Y Suzuki; Ana Alcaraz; Eric Y Denkers; Edward J Pearce
Interleukin-12 promotes pathologic liver changes and death in mice coinfected with Schistosoma mansoni and Toxoplasma gondii.
Infection and immunity 2001;69(3):1454-62.
2001: Sharon McGonigle; Melissa J Beall; E L Feeney; Edward J Pearce
Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors.
FEBS letters 2001;490(1-2):65-9.
2001: Anne Camille La Flamme; Elisabeth A Patton; Beverley E Bauman; Edward J Pearce
IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1903-11.
2001: Elisabeth A Patton; LR Brunet; Anne Camille La Flamme; JA Pedras-Vasconcelos; MA Kopf; Edward J Pearce
Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent.
Infection and immunity 2001;69(1):589-92.
2000: Melissa J Beall; Sharon McGonigle; Edward J Pearce
Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling.
Molecular and biochemical parasitology 2000;111(1):131-42.
2000: Anne Camille La Flamme; Andrew S MacDonald; Edward J Pearce
Role of IL-6 in directing the initial immune response to schistosome eggs.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2419-26.
1999: SJ Davies; Edward J Pearce
Atypical post-translational modification and targeting of a Schistosoma mansoni surface receptor, a member of the transforming growth factor beta receptor family of cell surface receptors.
Molecular and biochemical parasitology 1999;104(2):299-310.
1999: E L Racoosin; SJ Davies; Edward J Pearce
Caveolae-like structures in the surface membrane of Schistosoma mansoni.
Molecular and biochemical parasitology 1999;104(2):285-97.
1999: LR Brunet; Melissa J Beall; D W Dunne; Edward J Pearce
Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4976-84.
1999: AJ Marshall; LR Brunet; Y van Gessel; Ana Alcaraz; Susan K Bliss; Edward J Pearce; Eric Y Denkers
Toxoplasma gondii and Schistosoma mansoni synergize to promote hepatocyte dysfunction associated with high levels of plasma TNF-alpha and early death in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2089-97.
1999: LR Brunet; MA Kopf; Edward J Pearce
Schistosoma mansoni: IL-4 is necessary for concomitant immunity in mice.
The Journal of parasitology 1999;85(4):734-6.
1999: LR Brunet; E A Sabin; A W Cheever; MA Kopf; Edward J Pearce
Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells.
Infection and immunity 1999;67(6):3014-8.
1999: Anne Camille La Flamme; Edward J Pearce
The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5829-37.
1998: LR Brunet; D W Dunne; Edward J Pearce
Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection.
Parasitology today (Personal ed.) 1998;14(10):422-7.
1998: SJ Davies; C B Shoemaker; Edward J Pearce
A divergent member of the transforming growth factor beta receptor family from Schistosoma mansoni is expressed on the parasite surface membrane.
The Journal of biological chemistry 1998;273(18):11234-40.
1998: Edward J Pearce; Anne Camille La Flamme; E Sabin; LR Brunet
The initiation and function of Th2 responses during infection with Schistosoma mansoni.
Advances in experimental medicine and biology 1998;452():67-73.
1997: LR Brunet; F D Finkelman; A W Cheever; MA Kopf; Edward J Pearce
IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):777-85.
1997: Edward J Pearce; JA Pedras-Vasconcelos
Schistosoma mansoni infection induces a type 1 CD8+ cell response.
Behring Institute Mitteilungen 1997;(99):79-84.
1996: Edward J Pearce; J P Vasconcelos; LR Brunet; E A Sabin
IL-4 in schistosomiasis.
Experimental parasitology 1996;84(2):295-9.
1996: E A Sabin; MA Kopf; Edward J Pearce
Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils.
The Journal of experimental medicine 1996;184(5):1871-8.
1996: J A Pedras-Vasconcelos; Edward J Pearce
Type 1 CD8+ T cell responses during infection with the helminth Schistosoma mansoni.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):3046-53.
1996: Edward J Pearce; A Cheever; S Leonard; M Covalesky; R Fernandez-Botran; G Kohler; MA Kopf
Schistosoma mansoni in IL-4-deficient mice.
International immunology 1996;8(4):435-44.
1996: E A Sabin; M I Araujo; Edgar M Carvalho; Edward J Pearce
Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni.
The Journal of infectious diseases 1996;173(1):269-72.
1995: E A Sabin; Edward J Pearce
Early IL-4 production by non-CD4+ cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4844-53.
1995: S J Davies; Edward J Pearce
Surface-associated serine-threonine kinase in Schistosoma mansoni.
Molecular and biochemical parasitology 1995;70(1-2):33-44.
1994: D Humphries; A T Vella; Edward J Pearce
Increased CD4+ T cell-dependent anti-erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice.
Parasite immunology 1994;16(9):469-77.
1994: A T Vella; Edward J Pearce
Schistosoma mansoni egg-primed Th0 and Th2 cells: failure to down-regulate IFN-gamma production following in vitro culture.
Scandinavian journal of immunology 1994;39(1):12-8.
1993: A T Vella; Edward J Pearce
CD4+ T-cell receptor V beta usage during the immune response to Schistosoma mansoni.
Infection and immunity 1993;61(12):5381-3.
1992: A T Vella; M D Hulsebosch; Edward J Pearce
Schistosoma mansoni eggs induce antigen-responsive CD44-hi T helper 2 cells and IL-4-secreting CD44-lo cells. Potential for T helper 2 subset differentiation is evident at the precursor level.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(5):1714-22.
1992: A T Vella; Edward J Pearce
CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2283-90.
1991: Edward J Pearce; A Sher
Functional dichotomy in the CD4+ T cell response to Schistosoma mansoni.
Experimental parasitology 1991;73(1):110-6.