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Eric Pearlman

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TOP 3
Yan Sun; Rui Zhang; Thomas R Gadek; Charles A O'Neill; Eric Pearlman
Corneal Inflammation Is Inhibited by the LFA-1 Antagonist, Lifitegrast (SAR 1118).
Eric Pearlman; Sanhita Roy; Yan Sun; Loretta Szczotka-Flynn; Holly R Chinnery; Mahmoud Ghannoum; Amy G Hise; Mausita Karmakar; Paul G McMenamin; Arne Rietsch
Host defense at the ocular surface.
Mausita Karmakar; Arne Rietsch; Yan Sun; Amy G Hise; Eric Pearlman
Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.

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All Publications

2013: Yan Sun; Rui Zhang; Thomas R Gadek; Charles A O'Neill; Eric Pearlman
Corneal Inflammation Is Inhibited by the LFA-1 Antagonist, Lifitegrast (SAR 1118).
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2013;29(4):395-402.
2013: Eric Pearlman; Sanhita Roy; Yan Sun; Loretta Szczotka-Flynn; Holly R Chinnery; Mahmoud Ghannoum; Amy G Hise; Mausita Karmakar; Paul G McMenamin; Arne Rietsch
Host defense at the ocular surface.
International reviews of immunology 2013;32(1):4-18.
2012: Mausita Karmakar; Arne Rietsch; Yan Sun; Amy G Hise; Eric Pearlman
Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(9):4231-5.
2012: Sixto M Leal; Eric Pearlman
The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models.
Cytokine 2012;58(1):107-11.
2012: Yan Sun; Patricia R Taylor; Mausita Karmakar; Arne Rietsch; Eric Pearlman
ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(4):1884-95.
2012: Rong Zhou; Sean Platt; Yan Sun; Loretta Szczotka-Flynn; Rui Zhang; Eric Pearlman
Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection.
Investigative ophthalmology & visual science 2012;53(11):7382-8.
2011: Sanhita Roy; Yan Sun; Eric Pearlman
Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter.
The Journal of biological chemistry 2011;286(27):23753-62.
2010: Yan Sun; Mausita Karmakar; Sanhita Roy; Raniyah T Ramadan; Susan R Williams; Scott Howell; Carey L Shive; Yiping Han; Charles M Stopford; Arne Rietsch; Eric Pearlman
TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4272-83.
2010: Loretta Szczotka-Flynn; Eric Pearlman; Mahmoud Ghannoum
Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review.
Eye & contact lens 2010;36(2):116-29.
2010: Yan Sun; Jyotsna Chandra; Pranab Mukherjee; Loretta Szczotka-Flynn; Mahmoud A Ghannoum; Eric Pearlman
A murine model of contact lens-associated fusarium keratitis.
Investigative ophthalmology & visual science 2010;51(3):1511-6.
2010: Sixto M Leal; Susan Cowden; Yen-Cheng Hsia; Mahmoud A Ghannoum; Michelle Momany; Eric Pearlman
Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis.
PLoS pathogens 2010;6():e1000976.
2009: Loretta Szczotka-Flynn; Yoshifumi Imamura; Jyotsna Chandra; Changping Yu; Pranab K Mukherjee; Eric Pearlman; Mahmoud A Ghannoum
Increased resistance of contact lens-related bacterial biofilms to antimicrobial activity of soft contact lens care solutions.
Cornea 2009;28(8):918-26.
2009: Katrin Gentil; Eric Pearlman
Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis.
Infection and immunity 2009;77(4):1606-12.
2009: Yan Sun; Eric Pearlman
Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564).
Investigative ophthalmology & visual science 2009;50(3):1247-54.
2008: Eric Pearlman; Angela Johnson; Gautam Adhikary; Yan Sun; Holly R Chinnery; Todd Fox; Mark Kester; Paul G McMenamin
Toll-like receptors at the ocular surface.
The ocular surface 2008;6(3):108-16.
2008: Ahmad B Tarabishy; Bishr Aldabagh; Yan Sun; Yoshifumi Imamura; Pranab K Mukherjee; Jonathan H Lass; Mahmoud A Ghannoum; Eric Pearlman
MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):593-600.
2008: Michelle Lin; Patricia Jackson; Angus M Tester; Eugenia Diaconu; Christopher M Overall; J Edwin Blalock; Eric Pearlman
Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro.
The American journal of pathology 2008;173(1):144-53.
2008: Yan Sun; Todd Fox; Gautam Adhikary; Mark Kester; Eric Pearlman
Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide.
Journal of leukocyte biology 2008;83(6):1512-21.
2008: Gautam Adhikary; Yan Sun; Eric Pearlman
C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation.
Journal of leukocyte biology 2008;83(4):991-7.
2008: Angela C Johnson; Xiaoxia Li; Eric Pearlman
MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase.
The Journal of biological chemistry 2008;283(7):3988-96.
2008: Yoshifumi Imamura; Jyotsna Chandra; Pranab K Mukherjee; Ali Abdul Lattif; Loretta Szczotka-Flynn; Eric Pearlman; Jonathan H Lass; Kerry O'Donnell; Mahmoud A Ghannoum
Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type, and susceptibility to lens care solutions.
Antimicrobial agents and chemotherapy 2008;52(1):171-82.
2007: Eric C Carlson; Michelle Lin; Chia-Yang Liu; Winston W-Y Kao; Victor Perez Quinones; Eric Pearlman
Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
The Journal of biological chemistry 2007;282(49):35502-9.
2007: Illona Gillette-Ferguson; Katrin Daehnel; Amy G Hise; Yan Sun; Eric Carlson; Eugenia Diaconu; Helen F McGarry; Mark J Taylor; Eric Pearlman
Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis.
Infection and immunity 2007;75(12):5908-15.
2007: Katrin Daehnel; Illona Gillette-Ferguson; Amy G Hise; Eugenia Diaconu; M J Harling; Frederick P Heinzel; Eric Pearlman
Filaria/Wolbachia activation of dendritic cells and development of Th1-associated responses is dependent on Toll-like receptor 2 in a mouse model of ocular onchocerciasis (river blindness).
Parasite immunology 2007;29(9):455-65.
2007: Michelle Lin; Eric Carlson; Eugenia Diaconu; Eric Pearlman
CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis.
Journal of leukocyte biology 2007;81(3):786-92.
2007: Amy G Hise; Katrin Daehnel; Illona Gillette-Ferguson; Eun Cho; Helen F McGarry; Mark J Taylor; Douglas T Golenbock; Katherine A Fitzgerald; James W Kazura; Eric Pearlman
Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):1068-76.
2007: Eric Pearlman; Illona Gillette-Ferguson
Onchocerca volvulus, Wolbachia and river blindness.
Chemical immunology and allergy 2007;92():254-65.
2006: Yan Sun; Amy G Hise; Carolyn M Kalsow; Eric Pearlman
Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88.
Infection and immunity 2006;74(9):5325-32.
2006: Illona Gillette-Ferguson; Amy G Hise; Yan Sun; Eugenia Diaconu; Helen F McGarry; Mark J Taylor; Eric Pearlman
Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88.
Infection and immunity 2006;74(4):2442-5.
2005: Angela Johnson; Eric Pearlman
Toll-like receptors in the cornea.
The ocular surface 2005;3(4 Suppl):S187-9.
2005: Angela C Johnson; Frederick P Heinzel; Eugenia Diaconu; Yan Sun; Amy G Hise; Douglas T Golenbock; Jonathan H Lass; Eric Pearlman
Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
Investigative ophthalmology & visual science 2005;46(2):589-95.
2004: Illona Gillette-Ferguson; Amy G Hise; Helen F McGarry; Joseph Turner; Andrew Esposito; Yan Sun; Eugenia Diaconu; Mark J Taylor; Eric Pearlman
Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness).
Infection and immunity 2004;72(10):5687-92.
2004: Amy G Hise; Illona Gillette-Ferguson; Eric Pearlman
The role of endosymbiotic Wolbachia bacteria in filarial disease.
Cellular microbiology 2004;6(2):97-104.
2003: Eric Pearlman
Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria.
Medical microbiology and immunology 2003;192(1):57-60.
2003: Amy G Hise; Illona Gillette-Ferguson; Eric Pearlman
Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria.
Journal of endotoxin research 2003;9(6):390-4.
2002: Ravi B Berger; Nathan M Blackwell; Jonathan H Lass; Eugenia Diaconu; Eric Pearlman
IL-4 and IL-13 regulation of ICAM-1 expression and eosinophil recruitment in Onchocerca volvulus keratitis.
Investigative ophthalmology & visual science 2002;43(9):2992-7.
2002: Saloni Khatri; Jonathan H Lass; Frederick P Heinzel; W Matthew Petroll; John Gomez; Eugenia Diaconu; Carolyn M Kalsow; Eric Pearlman
Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4.
Investigative ophthalmology & visual science 2002;43(7):2278-84.
2002: Amélie v Saint André; Nathan M Blackwell; Laurie R Hall; Achim Hoerauf; Norbert W Brattig; Lars Volkmann; Mark J Taylor; Louise Ford; Amy G Hise; Jonathan H Lass; Eugenia Diaconu; Eric Pearlman
The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness.
Science (New York, N.Y.) 2002;295(5561):1892-5.
2002: Laurie R Hall; Ravi B Berger; Eugenia Diaconu; Eric Pearlman
Onchocerca volvulus keratitis (river blindness) is exacerbated in BALB/c IL-4 gene knockout mice.
Cellular immunology 2002;216(1-2):1-5.
2001: Laurie R Hall; Eugenia Diaconu; Eric Pearlman
A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):919-25.
2001: JT Kaifi; Eugenia Diaconu; Eric Pearlman
Distinct roles for PECAM-1, ICAM-1, and VCAM-1 in recruitment of neutrophils and eosinophils to the cornea in ocular onchocerciasis (river blindness).
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6795-801.
2001: Laurie R Hall; Eugenia Diaconu; R Patel; Eric Pearlman
CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness).
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4035-41.
2001: Rajeev K Mehlotra; Laurie R Hall; MA Haxhiu; Eric Pearlman
Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness.
Infection and immunity 2001;69(3):1463-8.
2000: Eric Pearlman; Laurie R Hall
Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness).
Parasite immunology 2000;22(12):625-31.
2000: JT Kaifi; Laurie R Hall; C Diaz; Joe Sypek; Eugenia Diaconu; Jonathan H Lass; Eric Pearlman
Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness).
Investigative ophthalmology & visual science 2000;41(12):3856-61.
2000: L Toè; AG Adjami; Boakye A Boatin; C Back; Edoh S Alley; N Dembélé; P G Brika; Eric Pearlman; Thomas R Unnasch
Topical application of diethylcarbamazine to detect onchocerciasis recrudescence in west Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94(5):519-25.
2000: Laurie R Hall; JT Kaifi; Eugenia Diaconu; Eric Pearlman
CD4(+) depletion selectively inhibits eosinophil recruitment to the cornea and abrogates Onchocerca volvulus keratitis (River blindness).
Infection and immunity 2000;68(9):5459-61.
2000: D L Martin; Christopher L King; Eric Pearlman; ER Strine; Frederick P Heinzel
IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):779-85.
1999: Laurie R Hall; Jonathan H Lass; Eugenia Diaconu; ER Strine; Eric Pearlman
An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4970-5.
1999: Eric Pearlman; L Toé; Boakye A Boatin; A A Gilles; AW Higgins; Thomas R Unnasch
Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine.
The Journal of infectious diseases 1999;180(4):1394-7.
1999: Eric Pearlman; Christine A Garhart; D J Grand; Eugenia Diaconu; ER Strine; Laurie R Hall
Temporal recruitment of neutrophils and eosinophils to the skin in a murine model for onchocercal dermatitis.
The American journal of tropical medicine and hygiene 1999;61(1):14-8.
1999: Laurie R Hall; Eric Pearlman
Pathogenesis of onchocercal keratitis (River blindness).
Clinical microbiology reviews 1999;12(3):445-53.
1998: D Matesic; Anna Valujskikh; Eric Pearlman; A W Higgins; Anita Gilliam; Peter S Heeger
Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5236-44.
1998: Rajeev K Mehlotra; Laurie R Hall; AW Higgins; Ismail A Dreshaj; MA Haxhiu; James W Kazura; Eric Pearlman
Interleukin-12 suppresses filaria-induced pulmonary eosinophilia, deposition of major basic protein and airway hyperresponsiveness.
Parasite immunology 1998;20(10):455-62.
1998: Laurie R Hall; Rajeev K Mehlotra; AW Higgins; MA Haxhiu; Eric Pearlman
An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness.
Infection and immunity 1998;66(9):4425-30.
1998: Eric Pearlman; Laurie R Hall; AW Higgins; David S Bardenstein; Eugenia Diaconu; Fred Hazlett; J Albright; James W Kazura; Jonathan H Lass
The role of eosinophils and neutrophils in helminth-induced keratitis.
Investigative ophthalmology & visual science 1998;39(7):1176-82.
1997: Eric Pearlman; Eugenia Diaconu; Fred Hazlett; Anthony Merriweather; Thomas R Unnasch
Identification of an epitope of a recombinant Onchocerca volvulus protein that induces corneal pathology.
Molecular and biochemical parasitology 1997;89(1):123-35.
1997: David S Bardenstein; Jonathan H Lass; James W Kazura; Eric Pearlman
Pleomorphism of stromal eosinophils in murine experimental onchocercal keratitis.
Ocular immunology and inflammation 1997;5(3):157-63.
1997: G Subramanian; James W Kazura; Eric Pearlman; X Jia; Indu Malhotra; Christopher L King
B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5914-20.
1997: Eric Pearlman; Jonathan H Lass; David S Bardenstein; Eugenia Diaconu; Fred Hazlett; J Albright; AW Higgins; James W Kazura
IL-12 exacerbates helminth-mediated corneal pathology by augmenting inflammatory cell recruitment and chemokine expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):827-33.
1996: Eric Pearlman; Jonathan H Lass; David S Bardenstein; Eugenia Diaconu; Fred Hazlett; J Albright; AW Higgins; James W Kazura
Onchocerca volvulus-mediated keratitis: cytokine production by IL-4-deficient mice.
Experimental parasitology 1996;84(2):274-81.
1996: D Liu; Eric Pearlman; Eugenia Diaconu; K Guo; H Mori; Tariq M Haqqi; Sanford Markowitz; James Willson; Man-Sun Sy
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7832-7.
1995: Eric Pearlman; Jonathan H Lass; David S Bardenstein; M Kopf; Fred Hazlett; Eugenia Diaconu; James W Kazura
Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness).
The Journal of experimental medicine 1995;182(4):931-40.
1995: Frederick P Heinzel; Ronald M Rerko; F Ahmed; Eric Pearlman
Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):730-9.
1995: Eric Pearlman; Frederick P Heinzel; Fred Hazlett; James W Kazura
IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4658-64.
1993: S D Mawhorter; Eric Pearlman; James W Kazura; W Henry Boom
Class II major histocompatibility complex molecule expression on murine eosinophils activated in vivo by Brugia malayi.
Infection and immunity 1993;61(12):5410-2.
1993: Eric Pearlman; James W Kazura; Fred Hazlett; W Henry Boom
Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4857-64.
1993: Eric Pearlman; Wesley K Kroeze; Fred Hazlett; S S Chen; S D Mawhorter; W Henry Boom; James W Kazura
Brugia malayi: acquired resistance to microfilariae in BALB/c mice correlates with local Th2 responses.
Experimental parasitology 1993;76(2):200-8.
1993: Eric Pearlman; Fred Hazlett; W Henry Boom; James W Kazura
Induction of murine T-helper-cell responses to the filarial nematode Brugia malayi.
Infection and immunity 1993;61(3):1105-12.
1992: James W Kazura; Fred Hazlett; Eric Pearlman; K Day; A el-Zeiny; T W Nilsen; Michael P Alpers
Antigenicity of a protective recombinant filarial protein in human bancroftian filariasis.
The Journal of infectious diseases 1992;166(6):1453-7.
1990: James W Kazura; P A Maroney; Eric Pearlman; T W Nilsen
Protective efficacy of a cloned Brugia malayi antigen in a mouse model of microfilaremia.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2260-4.