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Thomas Pearson

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R E Patzer; Thomas C Pearson
Racial disparities in kidney graft survival: does donor quality explain the difference?
I R Badell; J A Cano; Kenneth Cardona; Mandy L Ford; Allan D Kirk; F V Leopardi; Thomas C Pearson; M C Russell; V O Shaffer; Mingqing Song; Elizabeth Strobert; A P Turner; J G Avila; Christian P Larsen
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
Nicole A Turgeon; Sudha Tata; S Scott Davis; Allan D Kirk; Christian P Larsen; Edward Lin; Max Mondestin; Thomas C Pearson; Sebastian Perez; John F Sweeney
The impact of renal function on outcomes of bariatric surgery.

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All Publications

2012: R E Patzer; Thomas C Pearson
Racial disparities in kidney graft survival: does donor quality explain the difference?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(7):1670-1.
2012: I R Badell; J A Cano; Kenneth Cardona; Mandy L Ford; Allan D Kirk; F V Leopardi; Thomas C Pearson; M C Russell; V O Shaffer; Mingqing Song; Elizabeth Strobert; A P Turner; J G Avila; Christian P Larsen
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(7):1918-23.
2012: Nicole A Turgeon; Sudha Tata; S Scott Davis; Allan D Kirk; Christian P Larsen; Edward Lin; Max Mondestin; Thomas C Pearson; Sebastian Perez; John F Sweeney
The impact of renal function on outcomes of bariatric surgery.
Journal of the American Society of Nephrology : JASN 2012;23(5):885-94.
2011: Allan D Kirk; Stuart J Knechtle; Christian P Larsen; Kenneth A Newell; Thomas C Pearson
Miles to go….
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(6):1119-20.
2011: P Thompson; K Cardona; M Russell; I R Badell; V Shaffer; Gregory S Korbutt; Gina R Rayat; J Cano; M Song; W Jiang; E Strobert; Ray V Rajotte; Thomas C Pearson; Allan D Kirk; Christian P Larsen
CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(5):947-57.
2011: W Dar; A Agarwal; C Watkins; H M Gebel; Robert A. Bray; K E Kokko; Thomas C Pearson; Stuart J Knechtle
Donor-directed MHC class I antibody is preferentially cleared from sensitized recipients of combined liver/kidney transplants.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2011;11(4):841-7.
2011: Matthew R Weir; Shamkant Mulgaonkar; Laurence Chan; Hamid Shidban; Thomas H Waid; Dennis Preston; Roberto N Kalil; Thomas C Pearson
Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled Spare-the-Nephron trial.
Kidney international 2011;79(8):897-907.
2011: Christian P Larsen; Eric T. Elwood; Diane Z Alexander; Shannon C Ritchie; Rose Hendrix; Carol Tucker-Burden; Hong Rae Cho; Alejandro Aruffo; Diane Hollenbaugh; Peter S Linsley; Kevin J Winn; Thomas C Pearson
Pillars article: long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature. 1996. 381: 434-438. 1996.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2693-7.
2010: N A Turgeon; J G Avila; J A Cano; J J Hutchinson; I R Badell; A J Page; Andrew B Adams; M H Sears; P H Bowen; Allan D Kirk; Thomas C Pearson; Christian P Larsen
Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(9):2082-91.
2010: A Durrbach; J M Pestana; Thomas C Pearson; F Vincenti; V D Garcia; J Campistol; M del Carmen Rial; S Florman; A Block; G Di Russo; J Xing; P Garg; J Grinyó
A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study).
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(3):547-57.
2010: Diego R Martin; Saravanan K Krishnamoorthy; Bobby Kalb; Khalil Salman; Puneet Sharma; John D Carew; Phillip A Martin; Arlene B Chapman; Gaye L Ray; Christian P Larsen; Thomas C Pearson
Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols.
Journal of magnetic resonance imaging : JMRI 2010;31(2):440-6.
2009: Christopher R Gilson; Zvonimir Milas; Shivaprakash Gangappa; Diane L Hollenbaugh; Thomas C Pearson; Mandy L Ford; Christian P Larsen
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1625-35.
2009: Henrik Ekberg; Richard D Mamelok; Thomas C Pearson; Flavio Vincenti; Hélio Tedesco-Silva; Pierre Daloze
The challenge of achieving target drug concentrations in clinical trials: experience from the Symphony study.
Transplantation 2009;87(9):1360-6.
2008: A Anderson; C L Martens; Rose Hendrix; L L Stempora; W P Miller; Kelly Hamby; M Russell; Elizabeth Strobert; Bruce R Blazar; Thomas C Pearson; Christian P Larsen; Leslie S Kean
Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(11):2252-64.
2008: Mark R Rigby; Alison M Trexler; Thomas C Pearson; Christian P Larsen
CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.
Diabetes 2008;57(10):2672-83.
2008: Mandy L Ford; Maylene E Wagener; Samantha S Hanna; Thomas C Pearson; Allan D Kirk; Christian P Larsen
A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7203-11.
2008: Shivaprakash Gangappa; Kenneth E Kokko; Lisa M Carlson; Tania Gourley; Kenneth A Newell; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Immune responsiveness and protective immunity after transplantation.
Transplant international : official journal of the European Society for Organ Transplantation 2008;21(4):293-303.
2007: Kenneth Cardona; Zvonimir Milas; Elizabeth Strobert; J Cano; Wanhong Jiang; Susan A Safley; Shivaprakash Gangappa; B J Hering; Collin J Weber; Thomas C Pearson; Christian P Larsen
Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(10):2260-8.
2007: Brent Howard Koehn; Matthew A Williams; Keshawna Borom; Shivaprakash Gangappa; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2616-26.
2007: Kelly Hamby; A Trexler; Thomas C Pearson; Christian P Larsen; Mark R Rigby; Leslie S Kean
NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(8):1884-96.
2007: Mandy L Ford; Maylene E Wagener; Shivaprakash Gangappa; Thomas C Pearson; Christian P Larsen
Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(6):1471-81.
2007: Mandy L Ford; Brent Howard Koehn; Maylene E Wagener; Wanhong Jiang; Shivaprakash Gangappa; Thomas C Pearson; Christian P Larsen
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.
The Journal of experimental medicine 2007;204(2):299-309.
2007: Leslie S Kean; Andrew B Adams; Elizabeth Strobert; Rose Hendrix; Shivaprakash Gangappa; Thomas R Jones; Nozomu Shirasugi; Mark R Rigby; Kelly Hamby; J Jiang; H Bello; Dan Anderson; Kenneth Cardona; Megan M Durham; Thomas C Pearson; Christian P Larsen
Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(2):320-35.
2007: S Gangappa; Christian P Larsen; Thomas C Pearson
Alloimmunity: no toll exemption.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(1):3-4.
2006: Vaiva Vezys; David Masopust; Christopher C Kemball; Daniel L Barber; Leigh A O'Mara; Christian P Larsen; Thomas C Pearson; Rafi Ahmed; Aron E Lukacher
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.
The Journal of experimental medicine 2006;203(10):2263-9.
2006: Robert A. Bray; J D L Nolen; Christian P Larsen; Thomas C Pearson; Kenneth A Newell; Kenneth E Kokko; Antonio Guasch; P Tso; J B Mendel; Howard M. Gebel
Transplanting the highly sensitized patient: The emory algorithm.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(10):2307-15.
2006: E D Han Lee; Christopher C Kemball; Jun Wang; Ying Dong; D C Stapler; Kelly Hamby; Shivaprakash Gangappa; Kenneth A Newell; Thomas C Pearson; Aron E Lukacher; Christian P Larsen
A mouse model for polyomavirus-associated nephropathy of kidney transplants.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):913-22.
2006: Leslie S Kean; Shivaprakash Gangappa; Thomas C Pearson; Christian P Larsen
Transplant tolerance in non-human primates: progress, current challenges and unmet needs.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):884-93.
2006: Christian P Larsen; Stuart J Knechtle; A Adams; Thomas C Pearson; Allan D Kirk
A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):876-83.
2006: Kenneth Cardona; Gregory S Korbutt; Zvonimir Milas; James Lyon; Jose Cano; Wanhong Jiang; Hameeda Bello-Laborn; Brad Hacquoil; Elizabeth Strobert; Shivaprakash Gangappa; Collin J Weber; Thomas C Pearson; Ray V Rajotte; Christian P Larsen
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.
Nature medicine 2006;12(3):304-6.
2006: Nikos Emmanouilidis; Zhong Guo; Ying Dong; Marvin Newton-West; Andrew B Adams; Eun D Han Lee; Jun Wang; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells.
Transplantation 2006;81(3):455-62.
2006: Leslie S Kean; Kelly Hamby; Brent Howard Koehn; E Lee; S Coley; L Stempora; Andrew B Adams; E Heiss; Thomas C Pearson; Christian P Larsen
NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(2):292-304.
2006: Christopher C Kemball; Eun D Han Lee; Eva Szomolanyi-Tsuda; Thomas C Pearson; Christian P Larsen; Aron E Lukacher
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1814-24.
2006: William Marks; D Wagner; Thomas C Pearson; J P Orlowski; P W Nelson; Joshua J McGowan; Mary K Guidinger; James F Burdick
Organ donation and utilization, 1995-2004: entering the collaborative era.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 2):1101-10.
2005: Flavio Vincenti; Robert Mendez; John Curtis; Jimmy Light; Thomas C Pearson; You-Min Wu; Stephen M Katz; Enver Akalin; Robert M Esterl; Kristene Gugliuzza; Fuad S Shihab; Stanley Jordan; Johann Jonsson; Ernesto Molmenti; Ralph Barbeito
A multicenter, prospective study of C2-monitored cyclosporine microemulsion in a U.S. population of de novo renal transplant recipients.
Transplantation 2005;80(7):910-6.
2005: Christopher C Kemball; Eun D Han Lee; Vaiva Vezys; Thomas C Pearson; Christian P Larsen; Aron E Lukacher
Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7950-60.
2005: Christian P Larsen; Thomas C Pearson; Andrew B Adams; Paul Tso; Nozomu Shirasugi; Elizabeth Strobert; Dan Anderson; Shannon Cowan; Karen Price; Joseph Naemura; John Emswiler; JoAnne Greene; Lori Ann Turk; Jurgen Bajorath; Robert Townsend; David Hagerty; Peter Linsley; Robert Peach
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(3):443-53.
2005: Andrew B Adams; Nozomu Shirasugi; Thomas R Jones; Megan M Durham; Elizabeth Strobert; Shannon Cowan; Phyllis Rees; Rose Hendrix; Karen Price; Norma S Kenyon; David Hagerty; Robert Townsend; Diane L Hollenbaugh; Thomas C Pearson; Christian P Larsen
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):542-50.
2004: Nozomu Shirasugi; Nikos Emmanouilidis; Thomas C Pearson; Christian P Larsen
Ability of donor splenocytes with costimulation blockade to induce mixed hematopoietic chimerism and transplantation tolerance.
Transplantation proceedings 2004;36(8):2423-4.
2003: Thomas R Jones; Nozomu Shirasugi; Andrew B Adams; Thomas C Pearson; Christian P Larsen
Intravital microscopy identifies selectins that regulate T cell traffic into allografts.
The Journal of clinical investigation 2003;112(11):1714-23.
2003: Thomas R Jones; Andrew B Adams; Nozomu Shirasugi; Adam W Bingaman; Megan M Durham; Thomas C Pearson; Christian P Larsen
Allogeneic parenchymal and hematopoietic tissues differ in their ability to induce deletion of donor-reactive T cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(12):1520-30.
2003: Andrew B Adams; Thomas C Pearson; Christian P Larsen
Heterologous immunity: an overlooked barrier to tolerance.
Immunological reviews 2003;196():147-60.
2003: Paul L Tso; Michael P Cash; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Simultaneous pancreas-kidney transplantation utilizing a common arterial conduit: early experience and potential applications.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(11):1440-3.
2003: Zhong Guo; Jun Wang; Ying Dong; Andrew B Adams; Nozomu Shirasugi; Oliver Kim; John Hart; Marvin Newton-West; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(9):1091-8.
2003: Andrew B Adams; Nozomu Shirasugi; Thomas R Jones; Matthew A Williams; Megan M Durham; Jongwon Ha; Ying Dong; Zhong Guo; Kenneth A Newell; Thomas C Pearson; Christian P Larsen
Conventional immunosuppression is compatible with costimulation blockade-based, mixed chimerism tolerance induction.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):895-901.
2003: Andrew B Adams; Matthew A Williams; Thomas R Jones; Nozomu Shirasugi; Megan M Durham; Susan M Kaech; E John Wherry; Thandi M Onami; J Gibson Lanier; Kenneth E Kokko; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Heterologous immunity provides a potent barrier to transplantation tolerance.
The Journal of clinical investigation 2003;111(12):1887-95.
2003: Lena C Larsson; Matthias Corbascio; Thomas C Pearson; Christian P Larsen; Henrik Ekberg; Håkan Widner
Induction of operational tolerance to discordant dopaminergic porcine xenografts.
Transplantation 2003;75(9):1448-54.
2003: Matthew A Williams; Andrew B Adams; Melody B Walsh; Nozomu Shirasugi; Thandi M Onami; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Primary and secondary immunocompetence in mixed allogeneic chimeras.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2382-9.
2002: Violet A Kelley; Jennifer Everett-Kitchens; Laura E Brannon; Kathleen Connor; Enrique J Martinez; Thomas C Pearson; Frederick S. Nolte
Lack of seronegative hepatitis C virus infections in patients with chronic renal failure.
Transplantation 2002;74(10):1473-5.
2002: Matthew A Williams; Thandi M Onami; Andrew B Adams; Megan M Durham; Thomas C Pearson; Rafi Ahmed; Christian P Larsen
Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5387-91.
2002: Thomas C Pearson; Joel Trambley; Kris Odom; Daniel Anderson; Shannon Cowan; Robert A. Bray; Angello Lin; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; Elizabeth Strobert; Randolph A Hennigar; Christian P Larsen
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Transplantation 2002;74(7):933-40.
2002: Nozomu Shirasugi; Andrew B Adams; Megan M Durham; Aron E Lukacher; Huaying Xu; Phyllis Rees; Shannon Cowan; Matthew A Williams; Thomas C Pearson; Christian P Larsen
Prevention of chronic rejection in murine cardiac allografts: a comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2677-84.
2002: Matthias Corbascio; Harish D Mahanty; Cecilia Osterholm; Zhongquan Qi; Thomas C Pearson; Christian P Larsen; Chris E Freise; Henrik Ekberg
Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.
Transplantation 2002;74(1):35-41.
2002: Thandi M Onami; Laurie E Harrington; Matthew A Williams; Marisa Galvan; Christian P Larsen; Thomas C Pearson; N Manjunath; Linda G Baum; Brad D Pearce; Rafi Ahmed
Dynamic regulation of T cell immunity by CD43.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6022-31.
2002: Matthias Corbascio; Helene Ekstrand; Cecilia Osterholm; Zhongquan Qi; Mecislovas Simanaitis; Christian P Larsen; Thomas C Pearson; Kristian Riesbeck; Henrik Ekberg
CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely.
Transplant immunology 2002;10(1):55-61.
2002: Leslie S Kean; Megan M Durham; Andrew B Adams; Lewis Hsu; Jennifer R Perry; Dirck L Dillehay; Thomas C Pearson; Edmond WALLER; Christian P Larsen; David R Archer
A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation.
Blood 2002;99(5):1840-9.
2002: Andrew B Adams; Nozomu Shirasugi; Megan M Durham; Elizabeth Strobert; Dan Anderson; Phyllis Rees; Shannon Cowan; Huaying Xu; Yelena Blinder; Michael Cheung; Diane L Hollenbaugh; Norma S Kenyon; Thomas C Pearson; Christian P Larsen
Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.
Diabetes 2002;51(2):265-70.
2002: Thomas R Jones; Jongwon Ha; Matthew A Williams; Andrew B Adams; Megan M Durham; Phyllis Rees; Shannon Cowan; Thomas C Pearson; Christian P Larsen
The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1123-30.
2002: Helene Malm; Matthias Corbascio; Cecilia Osterholm; Shannon Cowan; Christian P Larsen; Thomas C Pearson; Henrik Ekberg
CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice.
Transplantation 2002;73(2):293-7.
2002: Andrew B Adams; Christian P Larsen; Thomas C Pearson; Kenneth A Newell
The role of TNF receptor and TNF superfamily molecules in organ transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(1):12-8.
2002: Lena C Larsson; Matthias Corbascio; Håkan Widner; Thomas C Pearson; Christian P Larsen; Henrik Ekberg
Simultaneous inhibition of B7 and LFA-1 signaling prevents rejection of discordant neural xenografts in mice lacking CD40L.
Xenotransplantation 2002;9(1):68-76.
2001: M Suresh; Jason K Whitmire; Laurie E Harrington; Christian P Larsen; Thomas C Pearson; John D Altman; Rafi Ahmed
Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5565-73.
2001: Matthew A Williams; Joyce T Tan; Andrew B Adams; Megan M Durham; Nozomu Shirasugi; Jason K Whitmire; Laurie E Harrington; Rafi Ahmed; Thomas C Pearson; Christian P Larsen
Characterization of virus-mediated inhibition of mixed chimerism and allospecific tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):4987-95.
2001: Adam W Bingaman; Jongwon Ha; Megan M Durham; SY Waitze; Carol Tucker-Burden; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4+ T cells in vivo.
Transplantation 2001;72(7):1286-92.
2001: Jongwon Ha; Adam W Bingaman; Megan M Durham; Thomas C Pearson; Christian P Larsen
Aggressive skin allograft rejection in CD28-/- mice independent of the CD40/CD40L costimulatory pathway.
Transplant immunology 2001;9(1):13-7.
2001: Enver Akalin; Rose Hendrix; Rohini Polavarapu; Thomas C Pearson; John F Neylan; Christian P Larsen; Fadi G Lakkis
Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology.
Transplantation 2001;72(5):948-53.
2001: Andrew B Adams; Megan M Durham; Leslie S Kean; Nozomu Shirasugi; Jongwon Ha; Matthew A Williams; Phyllis Rees; M C Cheung; Stephen Mittelstaedt; Adam W Bingaman; David R Archer; Thomas C Pearson; Edmond WALLER; Christian P Larsen
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1103-11.
2001: Andrew B Adams; Thomas C Pearson; Christian P Larsen
Conventional immunosuppression and co-stimulation blockade.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):703-5.
2001: Zhong Guo; L Meng; Oliver Kim; Jun Wang; John Hart; Gang He; Maria-Luisa Alegre; J Richard Thistlethwaite; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Transplantation 2001;71(9):1351-4.
2001: Joel Trambley; Angello Lin; Eric T. Elwood; Adam W Bingaman; Fadi G Lakkis; Matthias Corbascio; Thomas C Pearson; Christian P Larsen
FasL is important in costimulation blockade-resistant skin graft rejection.
Transplantation 2001;71(4):537-43.
2001: L Meng; Zhong Guo; Oliver Kim; Gang He; John Hart; Gregory L Szot; Jun Wang; Thomas C Pearson; Christian P Larsen; Kenneth A Newell
Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejection.
Transplantation proceedings 2001;33(1-2):418-20.
2000: Matthew A Williams; Joel Trambley; Jongwon Ha; Andrew B Adams; Megan M Durham; Phyllis Rees; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6849-57.
2000: Adam W Bingaman; Thomas C Pearson; Christian P Larsen
The role of CD40L in T cell-dependent nitric oxide production by murine macrophages.
Transplant immunology 2000;8(3):195-202.
2000: H L Triemer; Thomas C Pearson; K L Odom; Christian P Larsen
Analysis of a single-center experience with mycophenolate mofetil based immunosuppression in renal transplantation.
Clinical transplantation 2000;14(4 Pt 2):413-20.
2000: Joyce T Tan; Jongwon Ha; Hong Rae Cho; Carol Tucker-Burden; Rose Hendrix; Robert S Mittler; Thomas C Pearson; Christian P Larsen
Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses.
Transplantation 2000;70(1):175-83.
2000: Megan M Durham; Adam W Bingaman; Andrew B Adams; Jongwon Ha; SY Waitze; Thomas C Pearson; Christian P Larsen
Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):1-4.
2000: Adam W Bingaman; SY Waitze; DZ Alexander; Hong Rae Cho; Angello Lin; Carol Tucker-Burden; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Transplantation of the bone marrow microenvironment leads to hematopoietic chimerism without cytoreductive conditioning.
Transplantation 2000;69(12):2491-6.
2000: Adam W Bingaman; Jongwon Ha; SY Waitze; Megan M Durham; Hong Rae Cho; Carol Tucker-Burden; Rose Hendrix; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Vigorous allograft rejection in the absence of danger.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3065-71.
2000: Joyce T Tan; Jason K Whitmire; Kaja Murali-Krishna; Rafi Ahmed; John D Altman; Robert S Mittler; Alessandro Sette; Thomas C Pearson; Christian P Larsen
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2320-5.
1999: Joel Trambley; Adam W Bingaman; Angello Lin; Eric T. Elwood; SY Waitze; Jongwon Ha; Megan M Durham; Matthias Corbascio; Shannon Cowan; Thomas C Pearson; Christian P Larsen
Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.
The Journal of clinical investigation 1999;104(12):1715-22.
1999: Joyce T Tan; Jason K Whitmire; Rafi Ahmed; Thomas C Pearson; Christian P Larsen
4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4859-68.
1999: Jason K Whitmire; Richard A Flavell; Iqbal Grewal; Christian P Larsen; Thomas C Pearson; Rafi Ahmed
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3194-201.
1998: M Niimi; Thomas C Pearson; Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Alejandro Aruffo; Peter Linsley; E Thomas; K Campbell; W C Fanslow; R S Geha; Peter J Morris; Kathryn J Wood
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5331-7.
1998: Eric T. Elwood; Christian P Larsen; Hong Rae Cho; Matthias Corbascio; S C Ritchie; DZ Alexander; Carol Tucker-Burden; Peter Linsley; Alejandro Aruffo; Diane L Hollenbaugh; K J Winn; Thomas C Pearson
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation 1998;65(11):1422-8.
1998: Bogumila T Konieczny; Zhenhua Dai; Eric T. Elwood; S Saleem; Peter Linsley; Fady K Baddoura; Christian P Larsen; Thomas C Pearson; Fadi G Lakkis
IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2059-64.
1997: Christian P Larsen; Thomas C Pearson
The CD40 pathway in allograft rejection, acceptance, and tolerance.
Current opinion in immunology 1997;9(5):641-7.
1997: WW Shuford; K Klussman; D D Tritchler; DT Loo; J Chalupny; Anthony W Siadak; T J Brown; John Emswiler; H Raecho; Christian P Larsen; Thomas C Pearson; Jeffrey A Ledbetter; Alejandro Aruffo; Robert S Mittler
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
The Journal of experimental medicine 1997;186(1):47-55.
1997: Thomas C Pearson; P J Santamaria; K L Routenberg; D P O'Brien; John Whelchel; John F Neylan; Christian P Larsen
Drainage of the exocrine pancreas in clinical transplantation: comparison of bladder versus enteric drainage in a consecutive series.
Clinical transplantation 1997;11(3):201-5.
1997: Thomas C Pearson; DZ Alexander; Matthias Corbascio; Rose Hendrix; S C Ritchie; Peter Linsley; D Faherty; Christian P Larsen
Analysis of the B7 costimulatory pathway in allograft rejection.
Transplantation 1997;63(10):1463-9.
1997: Eric T. Elwood; Christian P Larsen; D H Maurer; K L Routenberg; John F Neylan; John Whelchel; D P O'Brien; Thomas C Pearson
Microchimerism and rejection in clinical transplantation.
Lancet 1997;349(9062):1358-60.
1997: Fadi G Lakkis; Bogumila T Konieczny; S Saleem; Fady K Baddoura; Peter Linsley; DZ Alexander; R P Lowry; Thomas C Pearson; Christian P Larsen
Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2443-8.
1996: Sandra M Waldrop; DZ Alexander; R Lowry; K J Winn; Thomas C Pearson; Ioannis Constantinidis
Analysis of allogeneic and syngeneic rat heart transplants using 23Na magnetic resonance spectroscopy.
Biochemical and biophysical research communications 1996;223(2):379-83.
1996: Christian P Larsen; Eric T. Elwood; DZ Alexander; S C Ritchie; R Hendrix; Carol Tucker-Burden; H R Cho; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; K J Winn; Thomas C Pearson
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature 1996;381(6581):434-8.
1996: Thomas C Pearson; DZ Alexander; R Hendrix; Eric T. Elwood; Peter Linsley; K J Winn; Christian P Larsen
CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism.
Transplantation 1996;61(7):997-1004.
1996: Collin J Weber; M K Hagler; J T Chryssochoos; Christian P Larsen; Thomas C Pearson; P Jensen; Judith A Kapp; Peter Linsley
CTLA4-Ig prolongs survival of microencapsulated rabbit islet xenografts in spontaneously diabetic Nod mice.
Transplantation proceedings 1996;28(2):821-3.
1996: DZ Alexander; Thomas C Pearson; R Hendrix; S C Ritchie; Christian P Larsen
Analysis of effector mechanisms in murine cardiac allograft rejection.
Transplant immunology 1996;4(1):46-8.
1996: Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Eric T. Elwood; S C Ritchie; Alejandro Aruffo; R Hendrix; Thomas C Pearson
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.
Transplantation 1996;61(1):4-9.
1996: John Whelchel; L C Hymes; E L Hochgelerent; Christian P Larsen; D C Lowance; D P O'Brien; John F Neylan; Thomas C Pearson; Barry L Warshaw
Evolving strategies in immunosuppressive therapy: the Emory experience.
Clinical transplants 1996;():249-55.
1995: Thomas C Pearson; A A Futral; K L Routenberg; D P O'Brien; John Whelchel; John F Neylan; Christian P Larsen
Delayed urinary bladder leak after combined kidney-pancreas transplantation. Association with penile prosthesis implantation.
Transplantation 1995;60(6):624-6.
1995: Christian P Larsen; DZ Alexander; R Hendrix; S C Ritchie; Thomas C Pearson
Fas-mediated cytotoxicity. An immunoeffector or immunoregulatory pathway in T cell-mediated immune responses?
Transplantation 1995;60(3):221-4.
1995: Andrew Bushell; Thomas C Pearson; Peter J Morris; Kathryn J Wood
Donor-recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor-specific transfusion and anti-CD4 antibody. Evidence of a clear role for short-term antigen persistence.
Transplantation 1995;59(10):1367-71.
1995: R P Lowry; Bogumila T Konieczny; D Alexander; Christian P Larsen; Thomas C Pearson; S Smith; S Narula
Interleukin-10 eliminates anti-CD3 monoclonal antibody-induced mortality and prolongs heart allograft survival in inbred mice.
Transplantation proceedings 1995;27(1):392-4.
1995: David A Gerber; Carl W Oettinger; Martin J D'Souza; GV Milton; Christian P Larsen; Thomas C Pearson
Prolongation of murine cardiac allograft survival by microspheres containing TNF alpha and IL1-beta neutralizing antibodies.
Journal of drug targeting 1995;3(4):311-5.
1994: Thomas C Pearson; DZ Alexander; K J Winn; Peter Linsley; R P Lowry; Christian P Larsen
Transplantation tolerance induced by CTLA4-Ig.
Transplantation 1994;57(12):1701-6.
1994: Christian P Larsen; S C Ritchie; R Hendrix; Peter Linsley; K S Hathcock; Richard J Hodes; R P Lowry; Thomas C Pearson
Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5208-19.
1994: J D Whelchel; C Larse; R Olsen; Thomas C Pearson; Andrea Risaliti; R Petri; Alessandro Uzzau; Gabriele Anania; Fabrizio Bresadola
Simultaneous pancreas kidney transplantation: initial experience of the Emory University transplant service.
International surgery 1994;79(2):98-102.
1993: Thomas C Pearson; Andrew Bushell; C R Darby; L J West; Peter J Morris; Kathryn J Wood
Lymphocyte changes associated with prolongation of cardiac allograft survival in adult mice using anti-CD4 monoclonal antibody.
Clinical and experimental immunology 1993;92(2):211-7.
1993: Thomas C Pearson; K Hamano; Peter J Morris; Kathryn J Wood
Anti-CD4 monoclonal antibody-induced allograft survival is associated with a defect in interleukin-2-dependent T-cell activation.
Transplantation proceedings 1993;25(1 Pt 1):786-7.
1993: Thomas C Pearson; C R Darby; Andrew Bushell; L J West; Peter J Morris; Kathryn J Wood
The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model.
Transplantation 1993;55(2):361-7.
1992: Christian P Larsen; S C Ritchie; Thomas C Pearson; Peter Linsley; R P Lowry
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
The Journal of experimental medicine 1992;176(4):1215-20.
1992: Thomas C Pearson; J C Madsen; Christian P Larsen; Peter J Morris; Kathryn J Wood
Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody.
Transplantation 1992;54(3):475-83.
1992: Thomas C Pearson; C R Darby; Kathryn J Wood
Successful secondary heterotopic cardiac transplantation in the mouse.
Transplantation 1992;53(3):701-3.
1991: A Bushnell; Thomas C Pearson; Peter J Morris; Kathryn J Wood
Donor-specific unresponsiveness to cardiac allografts in the mouse: an examination of mechanisms.
Transplantation proceedings 1991;23(1 Pt 1):726-8.
1991: Thomas C Pearson; J C Madsen; Kathryn J Wood
Effect of anti-CD4 monoclonal antibody dosage when combined with donor antigen for the induction of transplantation tolerance.
Transplantation proceedings 1991;23(1 Pt 1):565-6.
1991: Kathryn J Wood; Andrew Bushell; C R Darby; Thomas C Pearson; L West; Peter J Morris
Mechanism of induction of transplantation tolerance using donor antigen and anti-CD4 monoclonal antibody.
Transplantation proceedings 1991;23(1 Pt 1):133-4.
1990: Thomas C Pearson; J C Madsen; Peter J Morris; Kathryn J Wood
The induction of transplantation tolerance using donor antigen and CD4 monoclonal antibody.
Transplantation proceedings 1990;22(4):1955-6.