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Larry Pease

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Kevin Pavelko; Kathleen S Allen; Michael P Bell; Michael J Hansen; Lavakumar Karyampudi; Keith L Knutson; Larry R Pease
The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine.
Ashutosh K Mangalam; Larry R Pease; Moses Rodriguez; Michele K Smart; Shailendra Giri; David Luckey; Chella S David
Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.
Kevin Pavelko; Moses Rodriguez; Michael P Bell; Chella S David; Michael J Hansen; Aaron J Johnson; Yanice V Mendez-Fernandez; Larry R Pease
Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.

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All Publications

2013: Kevin Pavelko; Kathleen S Allen; Michael P Bell; Michael J Hansen; Lavakumar Karyampudi; Keith L Knutson; Larry R Pease
The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(5):1087-95.
2012: Ashutosh K Mangalam; Larry R Pease; Moses Rodriguez; Michele K Smart; Shailendra Giri; David Luckey; Chella S David
Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.
Journal of autoimmunity 2012;38(4):344-53.
2012: Kevin Pavelko; Moses Rodriguez; Michael P Bell; Chella S David; Michael J Hansen; Aaron J Johnson; Yanice V Mendez-Fernandez; Larry R Pease
Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.
PLoS pathogens 2012;8(2):e1002541.
2012: Arthur E Warrington; Virginia Van Keulen; Larry R Pease; Moses Rodriguez
Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?
Advances in experimental medicine and biology 2012;750():44-55.
2011: Adipong Brickshawana; Hirohito Kita; Virginia Smith Shapiro; Larry R Pease
Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):5795-804.
2011: Xiaohua Xu; Allan J Bieber; Larry R Pease; Virginia Van Keulen; Arthur E Warrington; Brent R Wright; Moses Rodriguez
A human IgM signals axon outgrowth: coupling lipid raft to microtubules.
Journal of neurochemistry 2011;119(1):100-12.
2011: Aleksandar Denic; Ramakrishna Edukulla; Jason Kerkvliet; Louisa M Papke; Larry R Pease; Allan J Bieber; Chella S David; Arthur E Warrington; Laurie J Zoecklein; Moses Rodriguez
Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis.
Brain pathology (Zurich, Switzerland) 2011;21(5):501-15.
2011: Aleksandar Denic; Brandon R Grossardt; Slobodan Macura; Larry R Pease; Istvan Pirko; Arthur E Warrington; Moses Rodriguez
A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination.
PloS one 2011;6(10):e26001.
2011: Kevin Pavelko; Megan A Girtman; Yoshihiro Mitsunaga; Yanice V Mendez-Fernandez; Michael P Bell; Michael J Hansen; Kathleen S Allen; Moses Rodriguez; Larry R Pease
Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy.
PloS one 2011;6(5):e20217.
2010: Laura N Arneson; Jadee L Upshaw; Charles L Howe; Sara J Felts; Moses Rodriguez; Larry R Pease; Marco Colonna
Retraction: TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6557.
2010: Loc T Nguyen; Bogoljub Ciric; Virginia P Van Keulen; Larry R Pease
Retraction: B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6554.
2010: Koji Iijima; Takao Kobayashi; Moses Rodriguez; Hirohito Kita; Larry R Pease
Retraction: Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6553.
2010: Loc T Nguyen; Bogoljub Ciric; Daren R Ure; Bin Zhou; Koji Tamada; Su-Yi Tseng; Tae Kwang Shin; Lieping Chen; Haidong Dong; Robert A Kyle; Moses Rodriguez; Larry R Pease
Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6552.
2010: Allan J Bieber; Kanitta Suwansrinon; Jason Kerkvliet; W Zhang; Larry R Pease; Moses Rodriguez
Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):792-7.
2009: Jason Kerkvliet; Laurie J Zoecklein; Louisa M Papke; Aleksandar Denic; Allan J Bieber; Larry R Pease; Chella S David; Moses Rodriguez
Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination.
Journal of virology 2009;83(23):12279-89.
2009: Moses Rodriguez; Arthur E Warrington; Larry R Pease
Invited article: human natural autoantibodies in the treatment of neurologic disease.
Neurology 2009;72(14):1269-76.
2009: Kevin Pavelko; Michael J Hansen; Larry R Pease
CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection.
Cancer research 2009;69(7):3114-20.
2009: Suresh Radhakrishnan; Rosalyn Cabrera; Kristina M Bruns; Virginia Van Keulen; Michael J Hansen; Sara J Felts; Larry R Pease
Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions.
PloS one 2009;4(4):e5373.
2008: Karin L Heckman; Suresh Radhakrishnan; Tobias Peikert; Koji Iijima; Hugh C McGregor; Michael P Bell; Hirohito Kita; Larry R Pease
T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.
European journal of immunology 2008;38(9):2464-74.
2008: Suresh Radhakrishnan; Rosalyn Cabrera; Erin L Schenk; Pilar Nava-Parada; Michael P Bell; Virginia Van Keulen; Ronald J Marler; Sara J Felts; Larry R Pease
Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3137-47.
2008: Kevin Pavelko; Karin L Heckman; Michael J Hansen; Larry R Pease
An effective vaccine strategy protective against antigenically distinct tumor variants.
Cancer research 2008;68(7):2471-8.
2008: Moses Rodriguez; Laurie J Zoecklein; Jason G Kerkvliet; Kevin Pavelko; Louisa M Papke; Charles Howe; Larry R Pease; Chella S David
Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination.
Journal of virology 2008;82(7):3369-80.
2007: Karin L Heckman; Erin L Schenk; Suresh Radhakrishnan; Kevin Pavelko; Michael J Hansen; Larry R Pease
Fast-tracked CTL: rapid induction of potent anti-tumor killer T cells in situ.
European journal of immunology 2007;37(7):1827-35.
2007: Kevin Pavelko; Larry R Pease; Chella S David; Moses Rodriguez
Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination.
Brain pathology (Zurich, Switzerland) 2007;17(2):184-96.
2007: Arthur E Warrington; Allan J Bieber; Bogoljub Ciric; Larry R Pease; Virginia Van Keulen; Moses Rodriguez
A recombinant human IgM promotes myelin repair after a single, very low dose.
Journal of neuroscience research 2007;85(5):967-76.
2007: Suresh Radhakrishnan; Karla R Wiehagen; Vesna Pulko; Virginia Van Keulen; William A Faubion; Keith L Knutson; Larry R Pease
Induction of a Th1 response from Th2-polarized T cells by activated dendritic cells: dependence on TCR:peptide-MHC interaction, ICAM-1, IL-12, and IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3583-92.
2007: Suresh Radhakrishnan; Loc T Nguyen; Bogoljub Ciric; Virginia Van Keulen; Larry R Pease
B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1426-32.
2007: Karin L Heckman; Larry R Pease
Gene splicing and mutagenesis by PCR-driven overlap extension.
Nature protocols 2007;2(4):924-32.
2006: Frank A Blocki; Suresh Radhakrishnan; Virginia Van Keulen; Karin L Heckman; Bogoljub Ciric; Charles Howe; Moses Rodriguez; Eugene Kwon; Larry R Pease
Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2408-10.
2006: Virginia Van Keulen; Bogoljub Ciric; S Radhakrishnan; Karin L Heckman; Yoshihiro Mitsunaga; K Iijima; H Kita; Moses Rodriguez; Larry R Pease
Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12.
Clinical and experimental immunology 2006;143(2):314-21.
2006: Moses Rodriguez; Laurie J Zoecklein; Jeff Gamez; Kevin Pavelko; Louisa M Papke; Shunya Nakane; Charles Howe; Suresh Radhakrishnan; Michael J Hansen; Chella S David; Arthur E Warrington; Larry R Pease
STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):343-5.
2005: Suresh Radhakrishnan; Koji Iijima; Takao Kobayashi; Hirohito Kita; Larry R Pease
Dendritic cells activated by cross-linking B7-DC (PD-L2) block inflammatory airway disease.
The Journal of allergy and clinical immunology 2005;116(3):668-74.
2005: Suresh Radhakrishnan; Esteban Celis; Larry R Pease
B7-DC cross-linking restores antigen uptake and augments antigen-presenting cell function by matured dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11438-43.
2005: Cari Roark Sloma; Michael J Hansen; Audrey A MacDougall; Virginia Van Keulen; Robert B Jenkins; Larry R Pease
A class I transgene reveals regulatory events on chromosome 1 marking peripheral T cell differentiation and memory.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7564-72.
2005: Aaron J Johnson; Yanice V Mendez-Fernandez; Ann M Moyer; Cari R Sloma; Istvan Pirko; Matthew S Block; Moses Rodriguez; Larry R Pease
Antigen-specific CD8+ T cells mediate a peptide-induced fatal syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6854-62.
2005: Richard Kennedy; Anita H Undale; William C Kieper; Matthew S Block; Larry R Pease; Esteban Celis
Direct cross-priming by th lymphocytes generates memory cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):3967-77.
2005: Matthew S Block; Yanice V Mendez-Fernandez; Virginia Van Keulen; Michael J Hansen; Kathleen S Allen; Anya L Taboas; Moses Rodriguez; Larry R Pease
Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2756-62.
2005: Yanice V Mendez-Fernandez; Michael J Hansen; Moses Rodriguez; Larry R Pease
Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.
Journal of virology 2005;79(5):3063-70.
2004: Istvan Pirko; Bogoljub Ciric; Jeff Gamez; Allan J Bieber; Arthur E Warrington; Aaron J Johnson; Dennis P Hanson; Larry R Pease; Slobodan Macura; Moses Rodriguez
A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1577-9.
2004: Suresh Radhakrishnan; Loc Tan Nguyen; Bogoljub Ciric; Dallas B Flies; Virginia Van Keulen; Koji Tamada; Lieping Chen; Moses Rodriguez; Larry R Pease
Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.
Cancer research 2004;64(14):4965-72.
2004: Arthur E Warrington; Allan J Bieber; Virginia Van Keulen; Bogoljub Ciric; Larry R Pease; Moses Rodriguez
Neuron-binding human monoclonal antibodies support central nervous system neurite extension.
Journal of neuropathology and experimental neurology 2004;63(5):461-73.
2004: Paul J Leibson; Larry R Pease
Having it both ways: MHC recognition in cis and trans.
Nature immunology 2004;5(3):237-8.
2004: Charles Howe; Allan J Bieber; Arthur E Warrington; Larry R Pease; Moses Rodriguez
Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.
Neurobiology of disease 2004;15(1):120-31.
2004: Bogoljub Ciric; Virginia Van Keulen; Mateo Paz Soldan; Moses Rodriguez; Larry R Pease
Antibody-mediated remyelination operates through mechanism independent of immunomodulation.
Journal of neuroimmunology 2004;146(1-2):153-61.
2004: Istvan Pirko; Aaron Johnson; Bogoljub Ciric; Jeff Gamez; Slobodan Macura; Larry R Pease; Moses Rodriguez
In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):179-82.
2003: Matthew S Block; Michael J Hansen; Virginia Van Keulen; Larry R Pease
MHC class I gene conversion mutations alter the CD8 T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4006-10.
2003: Bogoljub Ciric; Charles Howe; Mateo Paz Soldan; Arthur E Warrington; Allan J Bieber; Virginia Van Keulen; Moses Rodriguez; Larry R Pease
Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function.
Brain pathology (Zurich, Switzerland) 2003;13(4):608-16.
2003: Shunya Nakane; Laurie J Zoecklein; Jeff Gamez; Louisa M Papke; Kevin Pavelko; Jean-François Bureau; Michel Brahic; Larry R Pease; Moses Rodriguez
A 40-cM region on chromosome 14 plays a critical role in the development of virus persistence, demyelination, brain pathology and neurologic deficits in a murine viral model of multiple sclerosis.
Brain pathology (Zurich, Switzerland) 2003;13(4):519-33.
2003: Yanice V Mendez-Fernandez; Aaron J Johnson; Moses Rodriguez; Larry R Pease
Clearance of Theiler's virus infection depends on the ability to generate a CD8+ T cell response against a single immunodominant viral peptide.
European journal of immunology 2003;33(9):2501-10.
2003: Suresh Radhakrishnan; Loc T Nguyen; Bogoljub Ciric; Daren R Ure; Bin Zhou; Koji Tamada; Haidong Dong; Su-Yi Tseng; Tae Kwang Shin; Drew M Pardoll; Lieping Chen; Robert A Kyle; Moses Rodriguez; Larry R Pease
Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1830-8.
2003: M Mateo Paz Soldán; Arthur E Warrington; Allan J Bieber; Bogoljub Ciric; Virginia Van Keulen; Larry R Pease; Moses Rodriguez
Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair.
Molecular and cellular neurosciences 2003;22(1):14-24.
2002: Yanice V Mendez-Fernandez; R P Pogulis; Matthew S Block; A J Johnson; ST Kuhns; K S Allen; Michael J Hansen; Larry R Pease
Enhanced binding of low-affinity antibodies interacting simultaneously with targeted cell surface molecules and Fc receptor.
Tissue antigens 2002;60(6):515-25.
2002: Loc T Nguyen; Suresh Radhakrishnan; Bogoljub Ciric; Koji Tamada; Tae Kwang Shin; Drew M Pardoll; Lieping Chen; Moses Rodriguez; Larry R Pease
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.
The Journal of experimental medicine 2002;196(10):1393-8.
2002: Ryan A Wilcox; Dallas B Flies; Hao Wang; Koji Tamada; Aaron J Johnson; Larry R Pease; Moses Rodriguez; Yajun Guo; Lieping Chen
Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.
Cancer research 2002;62(15):4413-8.
2002: Yoshihiro Mitsunaga; Bogoljub Ciric; Virginia Van Keulen; Arthur E Warrington; Mateo Paz Soldan; Allan J Bieber; Moses Rodriguez; Larry R Pease
Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1325-7.
2002: Xiaoqi Lin; M Kariuki Njenga; Aaron J Johnson; Kevin Pavelko; Chella S David; Larry R Pease; Moses Rodriguez
Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination.
Journal of virology 2002;76(15):7799-811.
2002: Bogoljub Ciric; Larry R Pease
Malignant B cells and antigenic receptor: necessity or habit?
Leukemia & lymphoma 2002;43(7):1383-90.
2002: Ryan A Wilcox; Dallas B Flies; Gefeng Zhu; Aaron J Johnson; Koji Tamada; Andrei I Chapoval; Scott E Strome; Larry R Pease; Lieping Chen
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.
The Journal of clinical investigation 2002;109(5):651-9.
2002: Allan J Bieber; Arthur E Warrington; Kuni Asakura; Bogoljub Ciric; Srini V Kaveri; Larry R Pease; Moses Rodriguez
Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice.
Glia 2002;37(3):241-9.
2002: Paul D Murray; Dorian B McGavern; Larry R Pease; Moses Rodriguez
Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.
European journal of immunology 2002;32(3):606-15.
2002: Koji Tamada; Hideto Tamura; Dallas B Flies; Yang-Xin Fu; Esteban Celis; Larry R Pease; Bruce R Blazar; Lieping Chen
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.
The Journal of clinical investigation 2002;109(4):549-57.
2001: Aaron J Johnson; J Upshaw; Kevin Pavelko; M Rodriguez; Larry R Pease
Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2760-2.
2001: Allan J Bieber; Arthur E Warrington; Larry R Pease; Moses Rodriguez
Humoral autoimmunity as a mediator of CNS repair.
Trends in neurosciences 2001;24(11 Suppl):S39-44.
2001: Arthur E Warrington; Allan J Bieber; Bogoljub Ciric; Virginia Van Keulen; Larry R Pease; Yoshihiro Mitsunaga; Mateo Paz Soldan; Moses Rodriguez
Immunoglobulin-mediated CNS repair.
The Journal of allergy and clinical immunology 2001;108(4 Suppl):S121-5.
2001: Matthew S Block; Aaron J Johnson; Yanice V Mendez-Fernandez; Larry R Pease
Monomeric class I molecules mediate TCR/CD3 epsilon/CD8 interaction on the surface of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):821-6.
2001: Barbara A L Owen; Larry R Pease
Thermal stability of MHC class I-beta 2-microglobulin peptide complexes in the endoplasmic reticulum is determined by the peptide occupancy of the transporter associated with antigen processing complex.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1740-7.
2001: Bogoljub Ciric; V VanKeulen; Moses Rodriguez; R A Kyle; M A Gertz; Larry R Pease
Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor.
Blood 2001;97(1):321-3.
2000: Arthur E Warrington; Kuni Asakura; Allan J Bieber; Bogoljub Ciric; Virginia Van Keulen; Srini V Kaveri; R A Kyle; Larry R Pease; Moses Rodriguez
Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6820-5.
2000: ST Kuhns; Michelle Tallquist; Aaron J Johnson; Yanice V Mendez-Fernandez; Larry R Pease
T cell receptor interactions with class I heavy-chain influence T cell selection.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):756-60.
1999: Aaron J Johnson; M Kariuki Njenga; Michael J Hansen; ST Kuhns; Lieping Chen; Moses Rodriguez; Larry R Pease
Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.
Journal of virology 1999;73(5):3702-8.
1999: Barbara A L Owen; Larry R Pease
TAP association influences the conformation of nascent MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4677-84.
1999: Kristen Drescher; Paul D Murray; Chella S David; Larry R Pease; Moses Rodriguez
CNS cell populations are protected from virus-induced pathology by distinct arms of the immune system.
Brain pathology (Zurich, Switzerland) 1999;9(1):21-31.
1999: Xiaoqi Lin; Raymond P Roos; Larry R Pease; Peter J Wettstein; Moses Rodriguez
A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):17-24.
1998: ST Kuhns; Larry R Pease
A region of conformational variability outside the peptide-binding site of a class I MHC molecule.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6745-50.
1998: Robert Pogulis; Larry R Pease
A retroviral vector that directs simultaneous expression of alpha and beta T cell receptor genes.
Human gene therapy 1998;9(15):2299-304.
1998: Robert Pogulis; Michael J Hansen; Larry R Pease
Retroviral-mediated expression of an MHC class I-restricted T cell receptor in the CD8 T cell compartment of bone marrow-reconstituted mice.
Human gene therapy 1998;9(15):2285-97.
1998: Kuni Asakura; David Miller; Larry R Pease; Moses Rodriguez
Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(19):7700-8.
1998: Paul D Murray; Dorian B McGavern; Xiaoqi Lin; M Kariuki Njenga; J Leibowitz; Larry R Pease; Moses Rodriguez
Perforin-dependent neurologic injury in a viral model of multiple sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7306-14.
1998: Xiaoqi Lin; Larry R Pease; Paul D Murray; Moses Rodriguez
Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5661-8.
1998: Jean-François Bureau; Kristen Drescher; Larry R Pease; T Vikoren; M Delcroix; Laurie J Zoecklein; Michel Brahic; Moses Rodriguez
Chromosome 14 contains determinants that regulate susceptibility to Theiler's virus-induced demyelination in the mouse.
Genetics 1998;148(4):1941-9.
1998: K Christopher Garcia; M Degano; Larry R Pease; Mingdong Huang; PA Peterson; Luc Teyton; Ian A Wilson
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.
Science (New York, N.Y.) 1998;279(5354):1166-72.
1998: Xiaoqi Lin; S Sato; A K Patick; Larry R Pease; Raymond P Roos; Moses Rodriguez
Molecular characterization of a nondemyelinating variant of Daniel's strain of Theiler's virus isolated from a persistently infected glioma cell line.
Journal of virology 1998;72(2):1262-9.
1998: Michelle Tallquist; A J Weaver; Larry R Pease
Degenerate recognition of alloantigenic peptides on a positive-selecting class I molecule.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):802-9.
1997: K Christopher Garcia; Michelle Tallquist; Larry R Pease; AB Brunmark; CA Scott; M Degano; Enrico STURA; PA Peterson; Ian A Wilson; Luc Teyton
Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13838-43.
1997: M Kariuki Njenga; Kuni Asakura; SF Hunter; Peter J Wettstein; Larry R Pease; Moses Rodriguez
The immune system preferentially clears Theiler's virus from the gray matter of the central nervous system.
Journal of virology 1997;71(11):8592-601.
1997: Kristen Drescher; Larry R Pease; M Rodriguez
Antiviral immune responses modulate the nature of central nervous system (CNS) disease in a murine model of multiple sclerosis.
Immunological reviews 1997;159():177-93.
1997: M Kariuki Njenga; Larry R Pease; Peter J Wettstein; T Mak; Moses Rodriguez
Interferon alpha/beta mediates early virus-induced expression of H-2D and H-2K in the central nervous system.
Laboratory investigation; a journal of technical methods and pathology 1997;77(1):71-84.
1997: Xiaoqi Lin; Larry R Pease; Moses Rodriguez
Differential generation of class I H-2D- versus H-2K-restricted cytotoxicity against a demyelinating virus following central nervous system infection.
European journal of immunology 1997;27(4):963-70.
1997: T J Yun; R W Melvold; Larry R Pease
A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1384-9.
1996: Michelle Tallquist; T J Yun; Larry R Pease
A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity.
The Journal of experimental medicine 1996;184(3):1017-26.
1996: Robert Pogulis; A N Vallejo; Larry R Pease
In vitro recombination and mutagenesis by overlap extension PCR.
Methods in molecular biology (Clifton, N.J.) 1996;57():167-76.
1995: Kuni Asakura; David Miller; Robert Pogulis; Larry R Pease; Moses Rodriguez
Oligodendrocyte-reactive O1, O4, and HNK-1 monoclonal antibodies are encoded by germline immunoglobulin genes.
Brain research. Molecular brain research 1995;34(2):283-93.
1995: Xiaoqi Lin; N R Thiemann; Larry R Pease; Moses Rodriguez
VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.
Virology 1995;214(1):91-9.
1995: Michelle Tallquist; Larry R Pease
Alloreactive 2C T cells recognize a self peptide in the context of the mutant Kbm3 molecule.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2419-26.
1995: A N Vallejo; K S Allen; Larry R Pease
A common mutation in the hominoid class I A-locus IFN-responsive element results in the loss of enhancer activity.
International immunology 1995;7(5):853-9.
1995: A N Vallejo; Larry R Pease
Structure of the MHC A and B locus promoters in hominoids. Insights on the evolution of the class I MHC multigene family.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):3912-21.
1995: A N Vallejo; Larry R Pease
Evolution of class I promoter sequences: relationship to function and diversity.
Immunological reviews 1995;143():249-62.
1995: Robert Pogulis; N E Jacir; Larry R Pease
Polymorphism of the V alpha 15 T-cell receptor subfamily.
Molecular immunology 1995;32(1):93-5.
1994: A N Vallejo; Robert Pogulis; Larry R Pease
In vitro synthesis of novel genes: mutagenesis and recombination by PCR.
PCR methods and applications 1994;4(3):S123-30.
1994: T J Yun; Michelle Tallquist; E M Rohren; J M Sheil; Larry R Pease
Minor pocket B influences peptide binding, peptide presentation and alloantigenicity of H-2Kb.
International immunology 1994;6(7):1037-47.
1994: E M Rohren; D J McCormick; Larry R Pease
Peptide-induced conformational changes in class I molecules. Direct detection by flow cytometry.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5337-43.
1994: J K Pullen; Michelle Tallquist; R W Melvold; Larry R Pease
Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self peptide.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3445-52.
1994: Robert Pogulis; Larry R Pease
Alternative pre-mRNA splicing of Kj eliminates a sequence that is unique to H-2K transcripts.
Molecular immunology 1994;31(3):241-3.
1994: Robert Pogulis; J K Pullen; E M Rohren; Larry R Pease
Structural analysis of H-2Kj and H-2Ku.
Immunogenetics 1994;39(5):371.
1993: A Altintas; Z Cai; Larry R Pease; Moses Rodriguez
Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2803-12.
1993: Larry R Pease; R M Horton; J K Pullen; T J Yun
Unusual mutation clusters provide insight into class I gene conversion mechanisms.
Molecular and cellular biology 1993;13(7):4374-81.
1993: E M Rohren; Larry R Pease; H L Ploegh; Schumacher Ton
Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference.
The Journal of experimental medicine 1993;177(6):1713-21.
1993: Larry R Pease; R M Horton; J K Pullen; H D Hunt; T J Yun; E M Rohren; J L Prescott; S M Jobe; K S Allen
Amino acid changes in the peptide binding site have structural consequences at the surface of class I glycoproteins.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(8 Pt 1):3375-81.
1993: R M Horton; S N Ho; J K Pullen; H D Hunt; Z Cai; Larry R Pease
Gene splicing by overlap extension.
Methods in enzymology 1993;217():270-9.
1992: H D Hunt; T I Munitz; Larry R Pease
Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site.
The Journal of experimental medicine 1992;175(3):821-9.
1992: J K Pullen; R M Horton; Z L Cai; Larry R Pease
Structural diversity of the classical H-2 genes: K, D, and L.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):953-67.
1992: Z Cai; Larry R Pease
Structural and functional analysis of three D/L-like class I molecules from H-2v: indications of an ancestral family of D/L genes.
The Journal of experimental medicine 1992;175(2):583-96.
1992: W H Hildebrand; R M Horton; Larry R Pease; J M Martinko
Nucleotide sequence analysis of H-2Df and the spontaneous in vivo H-2Dfm2 mutation.
Molecular immunology 1992;29(1):61-9.
1992: Z Cai; J K Pullen; R M Horton; Larry R Pease
Specific amplification of complementary DNA from targeted members of multigene families.
Methods in enzymology 1992;216():100-8.
1991: R M Horton; B E Loveland; A Parwani; Larry R Pease; K F Lindahl
Characterization of the spontaneous mutant H-2Kbm29 indicates that gene conversion in H-2 occurs at a higher frequency than detected by skin grafting.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3180-4.
1991: R L Barker; R H Gundel; G J Gleich; J L Checkel; David Loegering; Larry R Pease; Kimm Hamann
Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity. Evidence of a functional role for ProMBP.
The Journal of clinical investigation 1991;88(3):798-805.
1991: J K Pullen; H D Hunt; Larry R Pease
Peptide interactions with the Kb antigen recognition site.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2145-51.
1991: B Y Wei; J M Buerstedde; M Bell; C Chase; A Nilson; A Browne; Larry R Pease; David J McKean
Functional effects of N-linked oligosaccharides located on the external domain of murine class II molecules.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2358-66.
1991: Z L Cai; Larry R Pease
An intragenic recombinant class I gene: H-2Ddx.
Immunogenetics 1991;34(4):273-6.
1991: Larry R Pease; R M Horton; J K Pullen; Z L Cai
Structure and diversity of class I antigen presenting molecules in the mouse.
Critical reviews in immunology 1991;11(1):1-32.
1990: A K Patick; Larry R Pease; Chella S David; Moses Rodriguez
Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice.
Journal of virology 1990;64(11):5570-6.
1990: R M Horton; W H Hildebrand; J M Martinko; Larry R Pease
Structural analysis of H-2Kf and H-2Kfm1 by using H-2K locus-specific sequences.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1782-7.
1990: H D Hunt; J K Pullen; R F Dick; J A Bluestone; Larry R Pease
Structural basis of Kbm8 alloreactivity. Amino acid substitutions on the beta-pleated floor of the antigen recognition site.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1456-62.
1990: Kimm Hamann; R M Ten; David Loegering; Robert B Jenkins; M T Heise; C R Schad; Larry R Pease; G J Gleich; R L Barker
Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.
Genomics 1990;7(4):535-46.
1990: R M Horton; Z L Cai; S N Ho; Larry R Pease
Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction.
BioTechniques 1990;8(5):528-35.
1990: R L Barker; David Loegering; K C Arakawa; Larry R Pease; G J Gleich
Cloning and sequence analysis of the human gene encoding eosinophil major basic protein.
Gene 1990;86(2):285-9.
1990: Z L Cai; Larry R Pease
Locus-specific cDNA cloning in the class I multigene family: structure of H-2Dr and H-2Ds.
Immunogenetics 1990;32(6):456-9.
1989: Kimm Hamann; R L Barker; David Loegering; Larry R Pease; G J Gleich
Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases.
Gene 1989;83(1):161-7.
1989: J K Pullen; H D Hunt; R M Horton; Larry R Pease
The functional significance of two amino acid polymorphisms in the antigen-presenting domain of class I MHC molecules. Molecular dissection of Kbm3.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1674-9.
1989: R L Barker; David Loegering; R M Ten; Kimm Hamann; Larry R Pease; G J Gleich
Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):952-5.
1989: K A Donovan; S K Singh; Chella S David; Larry R Pease
Molecular analysis and repair of a defective Ef alpha gene.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):4034-40.
1989: R M Ten; Larry R Pease; David J McKean; Michael P Bell; G J Gleich
Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family.
The Journal of experimental medicine 1989;169(5):1757-69.
1989: J M Buerstedde; A E Nilson; C G Chase; Michael P Bell; B N Beck; Larry R Pease; David J McKean
A beta polymorphic residues responsible for class II molecule recognition by alloreactive T cells.
The Journal of experimental medicine 1989;169(5):1645-54.
1989: R M Horton; H D Hunt; S N Ho; J K Pullen; Larry R Pease
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.
Gene 1989;77(1):61-8.
1989: S N Ho; H D Hunt; R M Horton; J K Pullen; Larry R Pease
Site-directed mutagenesis by overlap extension using the polymerase chain reaction.
Gene 1989;77(1):51-9.
1989: L W Duran; R M Horton; C W Birschbach; A Chang-Miller; Larry R Pease
Structural relationships among the H-2 D-regions of murine MHC haplotypes.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):288-96.
1988: R L Barker; G J Gleich; Larry R Pease
Acidic precursor revealed in human eosinophil granule major basic protein cDNA.
The Journal of experimental medicine 1988;168(4):1493-8.
1988: J M Buerstedde; Larry R Pease; A E Nilson; Michael P Bell; C Chase; G Buerstedde; David J McKean
Regulation of murine MHC class II molecule expression. Identification of A beta residues responsible for allele-specific cell surface expression.
The Journal of experimental medicine 1988;168(3):823-37.
1988: L W Duran; Larry R Pease
Tracing the evolution of H-2 D region genes using sequences associated with a repetitive element.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):295-301.
1988: J M Buerstedde; Larry R Pease; Michael P Bell; A E Nilson; G Buerstedde; D Murphy; David J McKean
Identification of an immunodominant region on the I-A beta chain using site-directed mutagenesis and DNA-mediated gene transfer.
The Journal of experimental medicine 1988;167(2):473-87.
1987: L W Duran; J C Zeller; J K Lundy; A Chang-Miller; Christopher J Krco; Chella S David; Larry R Pease
Genetic analysis of the H-2D region using a new intra-D-region recombinant mouse strain.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2818-24.
1987: B N Beck; Larry R Pease; Michael P Bell; J M Buerstedde; A E Nilson; G G Schlauder; David J McKean
DNA sequence analysis of I-Ak beta mutants reveals serologically immunodominant region.
The Journal of experimental medicine 1987;166(2):433-43.
1986: L W Duran; Larry R Pease
Relating the structure of major transplantation antigens to immune function.
Transplantation 1986;41(3):279-85.