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Oluf Pedersen

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Marie N Harder; Torben Jørgensen; Johanne M Justesen; Allan Linneberg; Ehm A Andersson; Niels Grarup; Torben Hansen; Rasmus Ribel-Madsen; Thomas Sparsø; Oluf Pedersen
Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased β-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort.
Rong Jiang; Oluf Pedersen; Ilene C Siegler; Abanish Singh; Thorkild I A Sørensen; Arne Astrup; Michael A Babyak; Beverly H Brummett; Torben Hansen; Elizabeth R Hauser; Claus Holst; Redford B Williams
Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.
A Bonnefond; Guillaume Charpentier; Sébastien Czernichow; Aurélie Dechaume; I Ezzidi; philippe froguel; Anette P Gjesing; Samy HADJADJ; Torben Hansen; Serge Hercberg; O Lantieri; Michel Marre; Oluf Pedersen; Julien Philippe; Emmanuel Vaillant; E A Andersson; Beverley Balkau; L Yengo; Martine Vaxillaire
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.

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All Publications

2013: Marie N Harder; Torben Jørgensen; Johanne M Justesen; Allan Linneberg; Ehm A Andersson; Niels Grarup; Torben Hansen; Rasmus Ribel-Madsen; Thomas Sparsø; Oluf Pedersen
Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased β-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate With Decreased Insulin Sensitivity in the Danish Inter99 Cohort.
The Journal of clinical endocrinology and metabolism 2013;98(4):E801-6.
2013: Rong Jiang; Oluf Pedersen; Ilene C Siegler; Abanish Singh; Thorkild I A Sørensen; Arne Astrup; Michael A Babyak; Beverly H Brummett; Torben Hansen; Elizabeth R Hauser; Claus Holst; Redford B Williams
Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.
Biological psychology 2013;93(1):184-9.
2013: A Bonnefond; Guillaume Charpentier; Sébastien Czernichow; Aurélie Dechaume; I Ezzidi; philippe froguel; Anette P Gjesing; Samy HADJADJ; Torben Hansen; Serge Hercberg; O Lantieri; Michel Marre; Oluf Pedersen; Julien Philippe; Emmanuel Vaillant; E A Andersson; Beverley Balkau; L Yengo; Martine Vaxillaire
Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes.
Diabetologia 2013;56(3):492-6.
2013: G Andersen; S Anthonsen; JO Clausen; L T Dalgaard; Torben Hansen; J Holmkvist; T Jørgensen; J M Justesen; T Lauritzen; T Nielsen; L W Thørner; D Witte; Oluf Pedersen
The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.
International journal of obesity (2005) 2013;37(2):175-81.
2013: Linn Gillberg; Anette P Gjesing; Torben Hansen; Stine Jacobsen; Charlotte Ling; Oluf Pedersen; Rasmus Ribel-Madsen; Trine W Boesgaard; Allan Vaag
Does DNA methylation of PPARGC1A influence insulin action in first degree relatives of patients with type 2 diabetes?
PloS one 2013;8(3):e58384.
2013: Amélie Bonnefond; Guillaume Charpentier; Aurélie Dechaume; Julia S El-Sayed Moustafa; philippe froguel; Niels Grarup; Samy HADJADJ; Torben Hansen; Serge Hercberg; Olivier Lantieri; Torsten Lauritzen; Michel Marre; Ndeye Coumba Ndiaye; Mohsen Azimi Nezhad; Oluf Pedersen; Ronan Roussel; Pierre-Jean Saulnier; Maria G Stathopoulou; Beverley Balkau; Sophie Visvikis-Siest
What is the contribution of two genetic variants regulating VEGF levels to type 2 diabetes risk and to microvascular complications?
PloS one 2013;8(2):e55921.
2013: K Færch; Torben Hansen; Torben Jørgensen; F K Knop; Oluf Pedersen; K Pilgaard; Jens Juul Holst
Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.
Diabetes, obesity & metabolism 2013;15(1):91-5.
2012: Anette P Gjesing; Oluf Pedersen
'Omics'-driven discoveries in prevention and treatment of type 2 diabetes.
European journal of clinical investigation 2012;42(6):579-88.
2012: Anette P Gjesing; Hans Eiberg; Claus T Ekstrøm; Jens Juul Holst; Oluf Pedersen; Søren A Urhammer; Torben Hansen
Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits.
Diabetologia 2012;55(5):1338-45.
2012: Anders Borglykke; Mogens Fenger; Niels Grarup; Torben Hansen; Jørgen Jeppesen; Allan Linneberg; Oluf Pedersen; Thomas Sparsø; Torben Jørgensen
Genetic variant SCL2A2 is associated with risk of cardiovascular disease--assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants.
PloS one 2012;7(11):e50418.
2012: Charlotte Steffensen; Reimar W Thomsen; Allan Vaag; Henning Beck-Nielsen; Jens Sandahl Christiansen; Torben Hansen; Oluf Pedersen; Jørgen Rungby
The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment.
Clinical epidemiology 2012;4(Suppl 1):7-13.
2012: Tanja Stocks; Moira A Taylor; Lars Angquist; Peter Arner; Arne Astrup; Karina Banasik; Jörg Hager; Torben Hansen; Marie N Harder; Claus Holst; Yoichiro Kamatani; Marie Kunesova; Dominique Langin; Ian A MacDonald; J Alfredo Martinez; Jean-Michel Oppert; Oluf Pedersen; Andreas F H Pfeiffer; Jan Polak; Stephan Rössner; Francis Rousseau; Wim H M Saris; Thorkild I A Sørensen
TFAP2B influences the effect of dietary fat on weight loss under energy restriction.
PloS one 2012;7(8):e43212.
2012: Nikolaj Thure Krarup; Oluf Pedersen; Pernille Poulsen; Camilla Helene Sandholt; Thorkild Sørensen; Allan Vaag; Daniel R Witte; Karina Banasik; Kristine Færch; Martin Friedrichsen; Niels Grarup; Torben Jørgensen; Torben Hansen
The PNPLA3 rs738409 G-allele associates with reduced fasting serum triglyceride and serum cholesterol in Danes with impaired glucose regulation.
PloS one 2012;7(7):e40376.
2012: Karina Banasik; Ehm Andersson; Mette Hollensted; Torben Jørgensen; Torsten Lauritzen; Oluf Pedersen; Annelli Sandbaek; Thomas Sparsø; Daniel R Witte; Torben Hansen
The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals.
BMC medical genetics 2012;13():10.
2012: K S Burgdorf; Anette P Gjesing; Niels Grarup; Torben Hansen; Torben Jørgensen; J M Justesen; Sten Madsbad; C H Sandholt; Daniel R Witte; Oluf Pedersen
Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals.
Diabetologia 2012;55(1):105-13.
2011: Jonas B Møller; Rune V Overgaard; Oluf Pedersen; William J Jusko; Henrik Madsen; Wei Gao; Torben Hansen; Jens J Holst; Steen H Ingwersen
Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test.
Journal of pharmacokinetics and pharmacodynamics 2011;38(6):713-25.
2011: Signe S Torekov; J Wang; Daniel R Witte; M Rosenkilde; Annelli Sandbaek; Niels Grarup; I A Hainerová; Torben Hansen; Bolette Hartmann; Jens Juul Holst; Torben Jørgensen; U Kielgast; Hannelouise Kissow; torsten lauritzen; J Lebl; A Linneberg; L Ma; Sten Madsbad; O D Madsen; Oluf Pedersen
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.
Diabetologia 2011;54(11):2820-31.
2011: Kirk E Lohmueller; Oluf Pedersen; Annelli Sandbaek; Geng Tian; Nicolas Vinckenbosch; Jun Wang; Daniel R Witte; Anders Albrechtsen; Alison F Feder; Niels Grarup; Torben Hansen; Ines Hellmann; Emilia Huerta-Sanchez; Tao Jiang; Torben Jørgensen; Su Yeon Kim; Thorfinn Korneliussen; Torsten Lauritzen; Yingrui Li; Rasmus Nielsen
Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.
PLoS genetics 2011;7(10):e1002326.
2011: T Nielsen; T Sparsø; N Grarup; Torben Jørgensen; Charlotta Pisinger; Daniel R Witte; Torben Hansen; Oluf Pedersen
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release.
Diabetologia 2011;54(5):1052-6.
2011: Lucie Gonsorcikova; Torben Hansen; Oluf Pedersen; Stepanka Pruhova; Martine Vaxillaire; Ondrej Cinek; Aurélie Dechaume; Petra Dusatkova; philippe froguel; Jan Lebl
Familial mild hyperglycemia associated with a novel ABCC8-V84I mutation within three generations.
Pediatric diabetes 2011;12(3 Pt 2):266-9.
2011: N Grarup; M Overvad; T Sparsø; Daniel R Witte; Charlotta Pisinger; Torben Jørgensen; T Yamauchi; K Hara; S Maeda; T Kadowaki; Torben Hansen; Oluf Pedersen
The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.
Diabetologia 2011;54(4):789-94.
2011: Lian Engelen; Søren S Lund; Isabel Ferreira; Lise Tarnow; Hans-Henrik Parving; Jørgen Gram; Kaj Winther; Oluf Pedersen; Tom Teerlink; Rob Barto; Coen D A Stehouwer; Allan A Vaag; Casper G Schalkwijk
Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(3):371-9.
2011: Niels H Birkebaek; P K A Jensen; Oluf Pedersen; Joan Solgaard Sørensen; J Vikre-Jørgensen; T Hansen
A De Novo Whole GCK Gene Deletion Not Detected by Gene Sequencing, in a Boy with Phenotypic GCK Insufficiency.
Case reports in genetics 2011;2011():768610.
2011: Ehm A Andersson; Kristine Færch; Niels Grarup; Marie N Harder; Torben Jørgensen; Johanna Kuusisto; Markku Laakso; Oluf Pedersen; Kasper Pilgaard; Charlotta Pisinger; Pernille Poulsen; Alena Stančáková; Allan Vaag; Daniel R Witte; Torben Hansen
The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.
PloS one 2011;6(11):e27096.
2011: Jacob P Thyssen; Berit C Carlsen; Kåre Engkilde; Torben Hansen; Jeanne D Johansen; Allan Linneberg; Michael Meldgaard; Oluf Pedersen; Flemming Pociot; Steen Stender; Pal B Szecsi; Torkil Menné
A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study.
BMJ open 2011;1(1):e000062.
2011: Lavinia Paternoster; Oluf Pedersen; Annelli Sandbaek; Beate St Pourcain; Nick Timpson; Daniel R Witte; Diana Zelenika; Anette Prior Gjesing; Ellen Aagaard Nohr; George Davey Smith; Paul Brennan; Katherine S Elliott; David M Evans; Valerie Gaborieau; Niels Grarup; Jörg Hager; Torben Hansen; Claus Holst; Torben Jørgensen; John P Kemp; Mark Lathrop; Torsten Lauritzen; Allan Linneberg; George McMahon; Thorkild I A Sørensen
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
PloS one 2011;6(9):e24303.
2011: Anette P Gjesing; Torben Hansen; Martin Heni; Jens J Holst; Torben Jørgensen; Marie A Vestmar; Daniel R Witte; Oluf Pedersen
The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status.
PloS one 2011;6(9):e23907.
2011: Camilla Helene Sandholt; Marie Aare Vestmar; Daniel Witte; Katrine Almind; Dorthe Sadowa Bille; Anders Borglykke; Lars Hansen; Torben Jørgensen; Torsten Lauritzen; Oluf Pedersen; Annelli Sandbaek; Torben Hansen
Studies of metabolic phenotypic correlates of 15 obesity associated gene variants.
PloS one 2011;6(9):e23531.
2011: Tracy B Shafizadeh; Torben Hansen; Torben Jorgensen; Janice A Kolberg; Edward J Moler; Uyen Thao Nguyen; Oluf Pedersen; Knut Borch-Johnsen
Comparison of accuracy of diabetes risk score and components of the metabolic syndrome in assessing risk of incident type 2 diabetes in Inter99 cohort.
PloS one 2011;6(7):e22863.
2011: Anette P Gjesing; Torben Hansen; Torben Jørgensen; Aneta A Nielsen; Amélie Bonnefond; Ivan Brandslund; Cramer Christensen; Phillippe Froguel; Annelli Sandbaek; Daniel R Witte; Oluf Pedersen
Studies of a genetic variant in HK1 in relation to quantitative metabolic traits and to the prevalence of type 2 diabetes.
BMC medical genetics 2011;12():99.
2011: Hong Jiao; Juha Kere; Oluf Pedersen; Ferdinand van't Hooft; Thorkild I A Sørensen; Peter Arner; Tomas Axelsson; David Brodin; Karine Clement; Sébastien Czernichow; Karin Dahlman-Wright; Beatrice Dubern; Anders Hamsten; Torben Hansen; Johannes Hebebrand; Johan Hoffstedt; Ingrid Dahlman
Genome wide association study identifies KCNMA1 contributing to human obesity.
BMC medical genomics 2011;4():51.
2011: José L Santos; Wim H M Saris; Thorkild I A Sorensen; Arne Astrup; Rolando De la Cruz; Katrine Grau; Torben Hansen; Claus Holst; Ian MacDonald; Alberto Maiz; J Alfredo Martinez; Carolina Naranjo; Jean-Michel Oppert; Oluf Pedersen
Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.
PloS one 2011;6(6):e19934.
2011: Dorthe S Bille; Torben Hansen; Jens-Christian Holm; Torben Jørgensen; Johanne M Justesen; Torsten Lauritzen; Annelli Sandbaek; Camilla H Sandholt; Daniel R Witte; Karina Banasik; Oluf Pedersen
Implications of central obesity-related variants in LYPLAL1, NRXN3, MSRA, and TFAP2B on quantitative metabolic traits in adult Danes.
PloS one 2011;6(6):e20640.
2011: Su Yeon Kim; Thorfinn Korneliussen; Yingrui Li; Kirk E Lohmueller; Anders Albrechtsen; Gitte Andersen; Niels Grarup; Torben Hansen; Tao Jiang; Torben Jorgensen; Oluf Pedersen; Geng Tian; Jun Wang; Daniel R Witte; Rasmus Nielsen
Estimation of allele frequency and association mapping using next-generation sequencing data.
BMC bioinformatics 2011;12():231.
2011: Karina Banasik; Johanne M Justesen; Malene Hornbak; Nikolaj T Krarup; Anette P Gjesing; Camilla H Sandholt; Thomas S Jensen; Niels Grarup; Asa Andersson; Torben Jørgensen; Daniel R Witte; Annelli Sandbaek; Torsten Lauritzen; Bernard Thorens; Søren Brunak; Thorkild I A Sørensen; Oluf Pedersen; Torben Hansen
Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease.
PloS one 2011;6(1):e16542.
2011: Sofia I Iqbal Kring; John C Barefoot; Beverly H Brummett; Stephen H Boyle; Ilene Siegler; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Redford B Williams; Thorkild I A Sørensen
Associations between APOE variants and metabolic traits and the impact of psychological stress.
PloS one 2011;6(1):e15745.
2011: Kristoffer Sølvsten Burgdorf; Niels Grarup; Johanne Marie Justesen; Marie Neergaard Harder; Daniel R Witte; Torben Jørgensen; Annelli Sandbaek; torsten lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.
PloS one 2011;6(1):e15813.
2011: Esther Zimmermann; Kristin Skogstrand; David M Hougaard; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen; Tine Jess
Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index.
PloS one 2011;6(1):e15958.
2011: Malene Hornbak; Karina Banasik; Johanne M Justesen; Nikolaj T Krarup; Camilla H Sandholt; Åsa Andersson; Annelli Sandbaek; torsten lauritzen; Charlotta Pisinger; Daniel R Witte; Thorkild A A Sørensen; Oluf Pedersen; Torben Hansen
The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load.
BMC medical genetics 2011;12():4.
2011: Anette P Gjesing; L L Kjems; M A Vestmar; Niels Grarup; A Linneberg; C F Deacon; J J Holst; Oluf Pedersen; Torben Hansen
Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.
Diabetologia 2011;54(1):103-10.
2011: Karina Banasik; Rasmus Ribel-Madsen; Anette P Gjesing; Lise Wegner; Asa Andersson; Pernille Poulsen; Anders Borglykke; Daniel R Witte; Oluf Pedersen; Torben Hansen; Allan Vaag
The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins.
The Journal of clinical endocrinology and metabolism 2011;96(1):E119-24.
2010: K Pilgaard; K Færch; B Carstensen; Pernille Poulsen; C Pisinger; Oluf Pedersen; Daniel R Witte; Torben Hansen; Torben Jørgensen; Allan Vaag
Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes.
Diabetologia 2010;53(12):2526-30.
2010: Stepanka Pruhova; Petra Dusatkova; Zdenek Sumnik; Stanislava Kolouskova; Oluf Pedersen; Torben Hansen; Ondrej Cinek; Jan Lebl
Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.
Pediatric diabetes 2010;11(8):529-35.
2010: E A Andersson; K Pilgaard; C Pisinger; M N Harder; N Grarup; K Faerch; P Poulsen; Daniel R Witte; T Jørgensen; A Vaag; T Hansen; Oluf Pedersen
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Diabetologia 2010;53(9):1908-16.
2010: T W Boesgaard; N Grarup; T Jørgensen; K Borch-Johnsen; T Hansen; Oluf Pedersen
Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.
Diabetologia 2010;53(8):1647-55.
2010: Su Yeon Kim; Yingrui Li; Yiran Guo; Ruiqiang Li; Johan Holmkvist; Torben Hansen; Oluf Pedersen; Jun Wang; Rasmus Nielsen
Design of association studies with pooled or un-pooled next-generation sequencing data.
Genetic epidemiology 2010;34(5):479-91.
2010: Kristoffer Sølvsten Burgdorf; Camilla Helene Sandholt; Thomas Sparsø; Gitte Andersen; Daniel R Witte; Torben Jørgensen; Anelli Sandbaek; torsten lauritzen; Thorkild I A Sørensen; Sten Madsbad; Torben Hansen; Oluf Pedersen
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
European journal of endocrinology / European Federation of Endocrine Societies 2010;163(1):81-7.
2010: Camilla Helene Sandholt; Thomas Sparsø; Niels Grarup; Anders Albrechtsen; Katrine Almind; Lars Hansen; Ulla Toft; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Combined analyses of 20 common obesity susceptibility variants.
Diabetes 2010;59(7):1667-73.
2010: Eva Corpeleijn; Liselotte Petersen; Claus Holst; Wim H Saris; Arne Astrup; Dominique Langin; Ian Macdonald; J Alfredo Martinez; Jean-Michel Oppert; Jan Polak; Oluf Pedersen; philippe froguel; Peter Arner; Thorkild I A Sørensen; Ellen E Blaak
Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.
Obesity (Silver Spring, Md.) 2010;18(7):1369-77.
2010: Ehm A Andersson; Birgitte Holst; Thomas Sparsø; Niels Grarup; Karina Banasik; Johan Holmkvist; Torben Jørgensen; Knut Borch-Johnsen; Kristoffer Lihme Egerod; Torsten Lauritzen; Thorkild I A Sørensen; Amélie Bonnefond; David Meyre; philippe froguel; Thue W Schwartz; Oluf Pedersen; Torben Hansen
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.
Diabetes 2010;59(6):1539-48.
2010: Amra C Alibegovic; Mette P Sonne; Lise Højbjerre; Torben Hansen; Oluf Pedersen; Gerrit van Hall; Jens J Holst; Bente Stallknecht; Flemming Dela; Allan Vaag
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.
Diabetes 2010;59(4):836-43.
2010: Rasmus Ribel-Madsen; Pernille Poulsen; Johan Holmkvist; Brynjulf Mortensen; Niels Grarup; Martin Friedrichsen; Torben Jørgensen; Torsten Lauritzen; Jørgen F P Wojtaszewski; Oluf Pedersen; Torben Hansen; Allan Vaag
Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle.
Diabetes 2010;59(4):1108-12.
2010: Gargi Meur; Albane Simon; Nasret Harun; Marie Virally; Aurélie Dechaume; Amélie Bonnefond; Sabrina Fetita; Andrei I Tarasov; Pierre-Jean Guillausseau; Trine Welløv Boesgaard; Oluf Pedersen; Torben Hansen; Michel Polak; Jean-François Gautier; philippe froguel; Guy A Rutter; Martine Vaxillaire
Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.
Diabetes 2010;59(3):653-61.
2010: Katrine Grau; Stephane Cauchi; Claus Holst; Arne Astrup; J Alfredo Martinez; Wim H M Saris; Ellen E Blaak; Jean-Michel Oppert; Peter Arner; Stephan Rössner; Ian A Macdonald; Eva Klimcakova; Dominique Langin; Oluf Pedersen; philippe froguel; Thorkild I A Sørensen
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.
The American journal of clinical nutrition 2010;91(2):472-9.
2010: Jonas B Møller; Rune V Overgaard; Henrik Madsen; Torben Hansen; Oluf Pedersen; Steen H Ingwersen
Predictive performance for population models using stochastic differential equations applied on data from an oral glucose tolerance test.
Journal of pharmacokinetics and pharmacodynamics 2010;37(1):85-98.
2010: Ehm A Andersson; Kasper Pilgaard; Charlotta Pisinger; Marie N Harder; Niels Grarup; Kristine Færch; Camilla Sandholt; Pernille Poulsen; Daniel R Witte; Torben Jørgensen; Allan Vaag; Oluf Pedersen; Torben Hansen
Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.
PloS one 2010;5(12):e14190.
2010: L L N Husemoen; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen; Allan Linneberg
The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.
PloS one 2010;5(8):e11735.
2010: Anette P Gjesing; Lesli H Larsen; Signe S Torekov; Irena Aldhoon Hainerová; Rahul Kapur; Anders Johansen; Anders Albrechtsen; Sylvia Boj; Birgitte Holst; Angela Harper; Søren A Urhammer; Knut Borch-Johnsen; Charlotta Pisinger; Søren M Echwald; Hans Eiberg; Arne Astrup; Jan Lebl; Jorge Ferrer; Thue W Schwartz; Torben Hansen; Oluf Pedersen
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity.
PloS one 2010;5(4):e10084.
2010: Trine W Boesgaard; Stepanka Pruhova; Ehm A Andersson; Ondrej Cinek; Barbora Obermannova; Jeannet Lauenborg; Peter Damm; Regine Bergholdt; Flemming Pociot; Charlotta Pisinger; Fabrizio Barbetti; Jan Lebl; Oluf Pedersen; Torben Hansen
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
BMC medical genetics 2010;11():42.
2010: Koji Okamoto; Naoko Iwasaki; Chisa Nishimura; Kent Doi; Eisei Noiri; Shinko Nakamura; Miho Takizawa; Makiko Ogata; Risa Fujimaki; Niels Grarup; Charlotta Pisinger; Knut Borch-Johnsen; Torsten Lauritzen; Annelli Sandbaek; Torben Hansen; Kazuki Yasuda; Haruhiko Osawa; Kishio Nanjo; Takashi Kadowaki; Masato Kasuga; Oluf Pedersen; Toshiro Fujita; Naoyuki Kamatani; Yasuhiko Iwamoto; Katsushi Tokunaga
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.
American journal of human genetics 2010;86(1):54-64.
2010: S I I Kring; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; T I A Sørensen
Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.
International journal of obesity (2005) 2010;34(1):182-9.
2010: Janniche Torsvik; Stefan Johansson; Anders Johansen; Jakob Ek; Jayne Minton; Helge Raeder; Sian Ellard; Andrew Hattersley; Oluf Pedersen; Torben Hansen; Anders Molven; Pål R Njølstad
Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes.
Human genetics 2010;127(1):55-64.
2009: Birgit M Nielsen; Marie M Nielsen; Søren Toubro; Oluf Pedersen; Arne Astrup; Thorkild I A Sørensen; Tine Jess; Berit L Heitmann
Past and current body size affect validity of reported energy intake among middle-aged Danish men.
The Journal of nutrition 2009;139(12):2337-43.
2009: Amélie Bonnefond; Martine Vaxillaire; Yann Labrune; Cécile Lecoeur; Jean-Claude Chèvre; Nabila Bouatia-Naji; Stéphane Cauchi; Beverley Balkau; Michel Marre; Jean Tichet; Jean-Pierre Riveline; Samy HADJADJ; Yves Gallois; Sébastien Czernichow; Serge Hercberg; Marika Kaakinen; Susanne Wiesner; Guillaume Charpentier; Claire Lévy-Marchal; Paul Elliott; Marjo-Riitta Jarvelin; Fritz Horber; Christian Dina; Oluf Pedersen; Robert Sladek; David Meyre; philippe froguel
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.
Diabetes 2009;58(11):2687-97.
2009: Christian Schack Rose; Niels Grarup; N T Krarup; P Poulsen; L Wegner; T Nielsen; Karina Banasik; K Faerch; Gitte Andersen; A Albrechtsen; Knut Borch-Johnsen; J O Clausen; T Jørgensen; Allan Vaag; Oluf Pedersen; T Hansen
A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.
Diabetologia 2009;52(10):2122-9.
2009: Louise G Grunnet; Emma Nilsson; Charlotte Ling; Torben Hansen; Oluf Pedersen; Leif Groop; Allan Vaag; Pernille Poulsen
Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue.
Diabetes 2009;58(10):2402-8.
2009: T W Boesgaard; T T Nielsen; K Josefsen; Torben Hansen; Torben Jørgensen; Oluf Pedersen; A Nørremølle; J E Nielsen; L Hasholt
Huntington's disease does not appear to increase the risk of diabetes mellitus.
Journal of neuroendocrinology 2009;21(9):770-6.
2009: Hana Koutnikova; Markku Laakso; Lu Lu; Roy Combe; Jussi Paananen; Teemu Kuulasmaa; Johanna Kuusisto; Hans-Ulrich Häring; Torben Hansen; Oluf Pedersen; Ulf Smith; Markolf Hanefeld; Robert Williams; Johan Auwerx
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.
PLoS genetics 2009;5(8):e1000591.
2009: Erwin Reiling; Jana V van Vliet-Ostaptchouk; Esther van 't Riet; Timon W van Haeften; Pascal A Arp; Torben Hansen; Dennis Kremer; Marlous J Groenewoud; Els C van Hove; Johannes A Romijn; Jan W A Smit; Giel Nijpels; Robert J Heine; André G Uitterlinden; Oluf Pedersen; P Eline Slagboom; J Antonie Maassen; Marten H Hofker; Leen M 't Hart; Jacqueline M Dekker
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.
European journal of human genetics : EJHG 2009;17(8):1056-62.
2009: Mickey Urdea; Janice Kolberg; Judith Wilber; Robert Gerwien; Edward Moler; Michael Rowe; Paul Jorgensen; Torben Hansen; Oluf Pedersen; Torben Jørgensen; Knut Borch-Johnsen
Validation of a multimarker model for assessing risk of type 2 diabetes from a five-year prospective study of 6784 Danish people (Inter99).
Journal of diabetes science and technology 2009;3(4):748-55.
2009: Janice A Kolberg; Torben Jørgensen; Robert W Gerwien; Sarah Hamren; Michael McKenna; Edward Moler; Michael W Rowe; Mickey S Urdea; Xiaomei M Xu; Torben Hansen; Oluf Pedersen; Knut Borch-Johnsen
Development of a type 2 diabetes risk model from a panel of serum biomarkers from the Inter99 cohort.
Diabetes care 2009;32(7):1207-12.
2009: Tine D Clausen; Elisabeth R Mathiesen; Torben Hansen; Oluf Pedersen; Dorte Møller Jensen; Jeannet Lauenborg; Lone Schmidt; Peter Damm
Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2009;94(7):2464-70.
2009: Thomas Sparsø; Niels Grarup; C Andreasen; Anders Albrechtsen; J Holmkvist; Gitte Andersen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen
Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction.
Diabetologia 2009;52(7):1308-14.
2009: K Pilgaard; C B Jensen; J H Schou; V Lyssenko; Lise Wegner; Charlotte Brøns; T Vilsbøll; Torben Hansen; Sten Madsbad; J J Holst; A Vølund; Pernille Poulsen; Leif Groop; Oluf Pedersen; Allan Vaag
The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.
Diabetologia 2009;52(7):1298-307.
2009: Oluf Pedersen
Intensified multifactorial treatment of patients with Type 2 diabetes: what can be achieved and does it pay off?
Journal of diabetes 2009;1(2):83-9.
2009: Thomas Sparsø; Amélie Bonnefond; Ehm Andersson; Nabila Bouatia-Naji; Johan Holmkvist; Lise Wegner; Niels Grarup; Anette P Gjesing; Karina Banasik; Christine Cavalcanti-Proença; Marion Marchand; Martine Vaxillaire; Guillaume Charpentier; Marjo-Riitta Jarvelin; Jean Tichet; Beverley Balkau; Michel Marre; Claire Lévy-Marchal; Kristine Faerch; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Pernille Poulsen; Allan Vaag; Christian Dina; Torben Hansen; Oluf Pedersen; philippe froguel
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
Diabetes 2009;58(6):1450-6.
2009: Susanne Engberg; Dorte Vistisen; Cathrine Lau; Charlotte Glümer; Torben Jørgensen; Oluf Pedersen; Knut Borch-Johnsen
Progression to impaired glucose regulation and diabetes in the population-based Inter99 study.
Diabetes care 2009;32(4):606-11.
2009: T Gylvin; Jakob Ek; Runa Louise Nolsoe; Anders Albrechtsen; Gitte Andersen; Regine Bergholdt; C Brorsson; C H Bang-Berthelsen; Torben Hansen; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Functional SOCS1 polymorphisms are associated with variation in obesity in whites.
Diabetes, obesity & metabolism 2009;11(3):196-203.
2009: Cathrine Lau; Ulla Toft; Inge Tetens; Bendix Carstensen; Torben Jørgensen; Oluf Pedersen; Knut Borch-Johnsen
Dietary patterns predict changes in two-hour post-oral glucose tolerance test plasma glucose concentrations in middle-aged adults.
The Journal of nutrition 2009;139(3):588-93.
2009: Dorit P Zobel; Camilla H Andreasen; Niels Grarup; Hans Eiberg; Thorkild I A Sørensen; Annelli Sandbaek; Torsten Lauritzen; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.
Diabetes 2009;58(3):757-64.
2009: Louise G Grunnet; Charlotte Brøns; Stine Jacobsen; Emma Nilsson; Arne Astrup; Torben Hansen; Oluf Pedersen; Pernille Poulsen; Bjørn Quistorff; Allan Vaag
Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609.
The Journal of clinical endocrinology and metabolism 2009;94(2):596-602.
2009: Søren S Lund; Lise Tarnow; Merete Frandsen; Bente B Nielsen; Birgitte V Hansen; Oluf Pedersen; Hans-Henrik Parving; Allan Vaag
Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.
BMJ (Clinical research ed.) 2009;339():b4324.
2009: Trine Welløv Boesgaard; Anette P Gjesing; Niels Grarup; Jarno Rutanen; Per-Anders Jansson; Marta Letizia Hribal; Giorgio Sesti; Andreas Fritsche; Norbert Stefan; Harald Staiger; Hans Häring; Ulf Smith; Markku Laakso; Oluf Pedersen; Torben Hansen
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study.
PloS one 2009;4(9):e7236.
2009: Anette P Gjesing; Thomas Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen; Niels V Olsen
No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes.
PloS one 2009;4(9):e7206.
2009: Sofia I I Kring; Thomas Werge; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen
Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes.
PloS one 2009;4(8):e6696.
2009: Camilla Noelle Rathcke; Johan Holmkvist; Lise Lotte N Husmoen; Torben Hansen; Oluf Pedersen; Henrik Vestergaard; Allan Linneberg
Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
PloS one 2009;4(7):e6106.
2009: Johan Holmkvist; Karina Banasik; Gitte Andersen; Hiroyuki Unoki; Thomas Skot Jensen; Charlotta Pisinger; Knut Borch-Johnsen; Annelli Sandbaek; torsten lauritzen; Sören Brunak; Shiro Maeda; Torben Hansen; Oluf Pedersen
The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.
PloS one 2009;4(6):e5872.
2009: Camilla Helene Andreasen; Mette Sloth Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; torsten lauritzen; Katrine Almind; Lars Hansen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.
BMC medical genetics 2009;10():17.
2009: Esther Zimmermann; Sofia I I Kring; Tina L Berentzen; Claus Holst; Tune H Pers; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen; Tine Jess
Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men.
PloS one 2009;4(2):e4428.
2009: Jeannet Lauenborg; Niels Grarup; Peter Damm; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Common type 2 diabetes risk gene variants associate with gestational diabetes.
The Journal of clinical endocrinology and metabolism 2009;94(1):145-50.
2008: Trine Nielsen; Kristoffer Sølvsten Burgdorf; Niels Grarup; Knut Borch-Johnsen; Torben Hansen; Torben Jørgensen; Oluf Pedersen; Gitte Andersen
The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.
Journal of hypertension 2008;26(11):2142-6.
2008: Lise Wegner; Meena S Hussain; Kasper Pilgaard; Torben Hansen; Oluf Pedersen; Allan Vaag; Pernille Poulsen
Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.
The Journal of clinical endocrinology and metabolism 2008;93(10):4013-9.
2008: Karani Santhanakrishnan Vimaleswaran; Jian'an Luan; Gitte Andersen; Y Li Muller; Eleanor Wheeler; Ema C Brito; Stephen O'Rahilly; Oluf Pedersen; Leslie J Baier; William C Knowler; Inês Barroso; Nicholas J Wareham; Ruth J F Loos; Paul W Franks
The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(4):1352-8.
2008: Hiroyuki Unoki; Atsushi Takahashi; Takahisa Kawaguchi; Kazuo Hara; Momoko Horikoshi; Gitte Andersen; Daniel P K Ng; Johan Holmkvist; Knut Borch-Johnsen; Torben Jørgensen; Annelli Sandbaek; torsten lauritzen; Torben Hansen; Siti Nurbaya; Tatsuhiko Tsunoda; Michiaki Kubo; Tetsuya Babazono; Hiroshi Hirose; Matsuhiko Hayashi; Yasuhiko Iwamoto; Atsunori Kashiwagi; Kohei Kaku; Ryuzo Kawamori; E Shyong Tai; Oluf Pedersen; Naoyuki Kamatani; Takashi Kadowaki; Ryuichi Kikkawa; Yusuke Nakamura; Shiro Maeda
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
Nature genetics 2008;40(9):1098-102.
2008: Tine Jess; Esther Zimmermann; S I I Kring; Tina Berentzen; Claus Holst; Søren Toubro; Arne Astrup; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen
Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study.
International journal of obesity (2005) 2008;32(9):1388-94.
2008: Thomas Sparsø; Gitte Andersen; Anders Albrechtsen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; J Wasson; M A Permutt; B Glaser; Sten Madsbad; Oluf Pedersen; Torben Hansen
Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation.
Diabetologia 2008;51(9):1646-52.
2008: Niels Grarup; Gitte Andersen; Nikolaj T Krarup; Anders Albrechtsen; Ole Schmitz; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
Diabetes 2008;57(9):2534-40.
2008: Ruth Gutiérrez-Aguilar; philippe froguel; Yasmin H Hamid; Yamina Benmezroua; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen; Bernadette Neve
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.
The Journal of clinical endocrinology and metabolism 2008;93(8):3128-35.
2008: Peter Gaede; William J Valentine; Andrew J Palmer; Daniel M D Tucker; Morten Lammert; Hans-Henrik Parving; Oluf Pedersen
Cost-effectiveness of intensified versus conventional multifactorial intervention in type 2 diabetes: results and projections from the Steno-2 study.
Diabetes care 2008;31(8):1510-5.
2008: Lucie Gonsorcíková; Stepánka Průhová; Ondrej Cinek; Jakob Ek; Terezie Pelikánová; Torben Jørgensen; Hans Eiberg; Oluf Pedersen; Torben Hansen; Jan Lebl
Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1.
Pediatric diabetes 2008;9(4 Pt 2):367-72.
2008: A Jorsal; Lise Tarnow; Maria Lajer; Jakob Ek; Torben Hansen; Oluf Pedersen; Hans-Henrik Parving
The PPAR gamma 2 Pro12Ala variant predicts ESRD and mortality in patients with type 1 diabetes and diabetic nephropathy.
Molecular genetics and metabolism 2008;94(3):347-51.
2008: Michael Benzinou; Jean-Claude Chèvre; Kirsten J Ward; Cécile Lecoeur; Christian Dina; Stephane Lobbens; Emmanuelle Durand; Jérôme Delplanque; Fritz F Horber; Barbara Heude; Beverley Balkau; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen; David Meyre; philippe froguel
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.
Human molecular genetics 2008;17(13):1916-21.
2008: Carlo Colombo; Ottavia Porzio; Ming Liu; Ornella Massa; Mario Vasta; Silvana Salardi; Luciano Beccaria; Carla Monciotti; Sonia Toni; Oluf Pedersen; Torben Hansen; Luca Federici; Roberta Pesavento; Francesco Cadario; Giorgio Federici; Paolo Ghirri; Peter Arvan; Dario Iafusco; Fabrizio Barbetti
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus.
The Journal of clinical investigation 2008;118(6):2148-56.
2008: Niels Grarup; Camilla H Andreasen; Mette K Andersen; Anders Albrechtsen; Annelli Sandbaek; Torsten Lauritzen; Knut Borch-Johnsen; Torben Jørgensen; Ole Schmitz; Torben Hansen; Oluf Pedersen
The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.
The Journal of clinical endocrinology and metabolism 2008;93(6):2294-9.
2008: Søren S Lund; Lise Tarnow; Coen D A Stehouwer; Casper G Schalkwijk; Tom Teerlink; Jørgen Gram; Kaj Winther; Merete Frandsen; Ulla M Smidt; Oluf Pedersen; Hans-Henrik Parving; Allan Vaag
Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(5):631-41.
2008: T W Boesgaard; J Zilinskaite; Markku Vänttinen; Markku Laakso; Per-Anders Jansson; Ann Hammarstedt; Ulf Smith; Norbert Stefan; A Fritsche; H Häring; M Hribal; Giorgio Sesti; D P Zobel; Oluf Pedersen; Torben Hansen
The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.
Diabetologia 2008;51(5):816-20.
2008: K Faerch; Allan Vaag; Jens Juul Holst; Charlotte Glümer; Oluf Pedersen; Knut Borch-Johnsen
Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action.
Diabetologia 2008;51(5):853-61.
2008: Gitte Andersen; Kristoffer Sølvsten Burgdorf; Thomas Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects.
Diabetes 2008;57(5):1427-32.
2008: Alena Stancáková; Jussi Pihlajamäki; Johanna Kuusisto; Norbert Stefan; Andreas Fritsche; Hans Häring; Francesco Andreozzi; Elena Succurro; Giorgio Sesti; Trine Welløv Boesgaard; Torben Hansen; Oluf Pedersen; Per-Anders Jansson; Ann Hammarstedt; Ulf Smith; Markku Laakso
Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.
The Journal of clinical endocrinology and metabolism 2008;93(5):1924-30.
2008: A P Gjesing; Gitte Andersen; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people.
Molecular genetics and metabolism 2008;94(1):90-7.
2008: J Holmkvist; S Anthonsen; Lise Wegner; Gitte Andersen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Oluf Pedersen; Torben Hansen
Polymorphisms in AHI1 are not associated with type 2 diabetes or related phenotypes in Danes: non-replication of a genome-wide association result.
Diabetologia 2008;51(4):609-14.
2008: Niels Grarup; Kirstine L Stender-Petersen; Ehm A Andersson; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects.
Diabetes 2008;57(4):1136-42.
2008: Markku Laakso; J Zilinskaite; T Hansen; T Welløv Boesgaard; Markku Vänttinen; A Stancáková; Per-Anders Jansson; F Pellmé; Jens J Holst; Tiina Kuulasmaa; M L Hribal; Giorgio Sesti; Norbert Stefan; A Fritsche; H Häring; Oluf Pedersen; Ulf Smith
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Diabetologia 2008;51(3):502-11.
2008: Peter Gaede; Henrik Lund-Andersen; Hans-Henrik Parving; Oluf Pedersen
Effect of a multifactorial intervention on mortality in type 2 diabetes.
The New England journal of medicine 2008;358(6):580-91.
2008: Harald Staiger; Alena Stancáková; Jone Zilinskaite; Markku Vänttinen; Torben Hansen; Maria Adelaide Marini; Ann Hammarstedt; Per-Anders Jansson; Giorgio Sesti; Ulf Smith; Oluf Pedersen; Markku Laakso; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring
A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study.
Diabetes 2008;57(2):514-7.
2008: Tine D Clausen; Elisabeth R Mathiesen; Torben Hansen; Oluf Pedersen; Dorte Møller Jensen; Jeannet Lauenborg; Peter Damm
High prevalence of type 2 diabetes and pre-diabetes in adult offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia.
Diabetes care 2008;31(2):340-6.
2008: Sofia Inez Iqbal Kring; Lesli Hingstrup Larsen; Claus Holst; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Thorkild I A Sørensen
Genotype-phenotype associations in obesity dependent on definition of the obesity phenotype.
Obesity facts 2008;1(3):138-45.
2008: Camilla Helene Andreasen; Mette Sloth Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; torsten lauritzen; Katrine Almind; Lars Hansen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits.
BMC medical genetics 2008;9():118.
2008: Björn Friedrich; Peter Weyrich; Alena Stancáková; Jianjung Wang; Johanna Kuusisto; Markku Laakso; Giorgio Sesti; Elena Succurro; Ulf Smith; Torben Hansen; Oluf Pedersen; Fausto Machicao; Silke Schäfer; Florian Lang; Teut Risler; Susanne Ullrich; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring
Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies.
PloS one 2008;3(11):e3506.
2008: Sofia I I Kring; Claus Holst; Esther Zimmermann; Tine Jess; Tina Berentzen; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Thorkild I A Sørensen
FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness.
PloS one 2008;3(8):e2958.
2008: Camilla H Andreasen; Mette S Mogensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Thorkild I A Sørensen; Lars Hansen; Katrine Almind; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes.
PloS one 2008;3(8):e2872.
2008: Søren S Lund; Lise Tarnow; Merete Frandsen; Ulla M Smidt; Oluf Pedersen; Hans-Henrik Parving; Allan Vaag
Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2008;158(1):35-46.
2008: Thomas Sparsø; Gitte Andersen; T Nielsen; K S Burgdorf; A P Gjesing; A L Nielsen; Anders Albrechtsen; Signe S Rasmussen; Torben Jørgensen; Knut Borch-Johnsen; Annelli Sandbaek; Torsten Lauritzen; Sten Madsbad; Torben Hansen; Oluf Pedersen
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
Diabetologia 2008;51(1):70-5.
2008: Camilla H Andreasen; Kirstine L Stender-Petersen; Mette S Mogensen; Signe S Torekov; Lise Wegner; Gitte Andersen; Arne L Nielsen; Anders Albrechtsen; Knut Borch-Johnsen; Signe S Rasmussen; Jesper O Clausen; Annelli Sandbaek; Torsten Lauritzen; Lars Hansen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation.
Diabetes 2008;57(1):95-101.
2007: Niels Grarup; Christian Schack Rose; Ehm A Andersson; Gitte Andersen; Arne L Nielsen; Anders Albrechtsen; Jesper O Clausen; Signe S Rasmussen; Torben Jørgensen; Annelli Sandbaek; Torsten Lauritzen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
Diabetes 2007;56(12):3105-11.
2007: Ottavia Porzio; Ornella Massa; Veronica Cunsolo; C Colombo; M Malaponti; Federico Bertuzzi; T Hansen; A Johansen; Oluf Pedersen; Franco Meschi; Alessandro Terrinoni; Gerry Melino; Massimo Federici; N Decarlo; Michele Menicagli; Daniela Campani; Piero Marchetti; M Ferdaoussi; philippe froguel; Giorgio Federici; Martine Vaxillaire; Fabrizio Barbetti
Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online.
Human mutation 2007;28(11):1150.
2007: Thomas Sparsø; Meena Shaheen Hussain; Knut Borch-Johnsen; Torben Jørgensen; Sten Madsbad; Torben Hansen; Oluf Pedersen; Gitte Andersen
Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites.
Molecular genetics and metabolism 2007;92(3):278-82.
2007: Masumi Kamiyama; Masaaki Kobayashi; Shin-ichi Araki; Aritoshi Iida; Tatsuhiko Tsunoda; Koichi Kawai; Masahito Imanishi; Makoto Nomura; Tetsuya Babazono; Yasuhiko Iwamoto; Atsunori Kashiwagi; Kohei Kaku; Ryuzo Kawamori; Daniel P K Ng; Torben Hansen; Peter Gaede; Oluf Pedersen; Yusuke Nakamura; Shiro Maeda
Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy.
Human genetics 2007;122(3-4):397-407.
2007: Irena Hainerová; Lesli H Larsen; Birgitte Holst; Marie Finková; Vojtech Hainer; Jan Lebl; Torben Hansen; Oluf Pedersen
Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.
The Journal of clinical endocrinology and metabolism 2007;92(9):3689-96.
2007: C Ling; Lise Wegner; Gitte Andersen; Peter Almgren; Torben Hansen; Oluf Pedersen; Leif Groop; Allan Vaag; Pernille Poulsen
Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle.
Diabetologia 2007;50(8):1615-20.
2007: T W Boesgaard; S I Castella; Gitte Andersen; Anders Albrechtsen; Thomas Sparsø; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(7):702-6.
2007: Ingrid Dahlman; Andrea Dicker; Hong Jiao; Juha Kere; Lennart Blomqvist; Vanessa van Harmelen; Johan Hoffstedt; Knut Borch-Johnsen; Torben Jorgensen; Torben Hansen; Oluf Pedersen; Markku Laakso; Peter Arner
A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.
American journal of human genetics 2007;80(6):1115-24.
2007: Anders Albrechtsen; Sofie Castella; Gitte Andersen; Torben Hansen; Oluf Pedersen; Rasmus Nielsen
A Bayesian multilocus association method: allowing for higher-order interaction in association studies.
Genetics 2007;176(2):1197-208.
2007: Niels Grarup; Anders Albrechtsen; Jakob Ek; Knut Borch-Johnsen; Torben Jørgensen; Ole Schmitz; Torben Hansen; Oluf Pedersen
Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people.
Diabetologia 2007;50(6):1201-8.
2007: Peter Gaede; Oluf Pedersen
Rosiglitazone monotherapy for type 2 diabetes mellitus-too soon to ADOPT?
Nature clinical practice. Endocrinology & metabolism 2007;3(6):456-7.
2007: Søren S Lund; Lise Tarnow; C D A Stehouwer; C G Schalkwijk; M Frandsen; Ulla M Smidt; Oluf Pedersen; Hans-Henrik Parving; Allan Vaag
Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial.
Diabetes, obesity & metabolism 2007;9(3):394-407.
2007: Dorit P Jensen; Camilla H Andreasen; Mette K Andersen; Lars Hansen; Hans Eiberg; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites.
Journal of molecular medicine (Berlin, Germany) 2007;85(5):445-9.
2007: Anette P Gjesing; Gitte Andersen; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(4):392-7.
2007: Lise Wegner; Gitte Andersen; Thomas Sparsø; Niels Grarup; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites.
Diabetes 2007;56(3):694-8.
2007: Anette P Gjesing; Gitte Andersen; K S Burgdorf; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of the associations between functional beta2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects.
Diabetologia 2007;50(3):563-8.
2007: Torben Hansen; Thomas Drivsholm; Søren A Urhammer; Rene T Palacios; Aage Voelund; Knut Borch-Johnsen; Oluf Pedersen
The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance.
Diabetes care 2007;30(2):257-62.
2007: Thomas Sparsø; Meena S Hussain; Gitte Andersen; Irena Hainerova; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people.
Molecular genetics and metabolism 2007;90(2):205-9.
2007: Lesli H Larsen; Christian Schack Rose; Thomas Sparsø; J Overgaard; Signe S Torekov; Niels Grarup; Dorit P Jensen; Anders Albrechtsen; Gitte Andersen; Jakob Ek; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes.
International journal of obesity (2005) 2007;31(2):365-70.
2007: Tina Berentzen; L Petersen; Oluf Pedersen; E Black; A Astrup; Thorkild I A Sørensen
Long-term effects of leisure time physical activity on risk of insulin resistance and impaired glucose tolerance, allowing for body weight history, in Danish men.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(1):63-72.
2007: Daniela Pinterova; Jakob Ek; Katarina Kolostova; Stepanka Pruhova; Peter Novota; Marianna Romzova; E Feigerlova; Marie Cerna; Jan Lebl; Oluf Pedersen; Torben Hansen
Six novel mutations in the GCK gene in MODY patients.
Clinical genetics 2007;71(1):95-6.
2007: Niels Grarup; Mette K Andersen; Camilla H Andreasen; Anders Albrechtsen; Knut Borch-Johnsen; Torben Jørgensen; Johan Auwerx; Ole Schmitz; Torben Hansen; Oluf Pedersen
Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects.
The Journal of clinical endocrinology and metabolism 2007;92(1):363-6.
2006: Jose L Santos; Philippe Boutin; Camilla Verdich; Claus Holst; Lesli H Larsen; Søren Toubro; Christian Dina; Wim H M Saris; Ellen E Blaak; Johan Hoffstedt; Moira A Taylor; Jan Polak; Karine Clement; Dominique Langin; Arne Astrup; philippe froguel; Oluf Pedersen; Thorkild I A Sorensen; J Alfredo Martinez
Genotype-by-nutrient interactions assessed in European obese women. A case-only study.
European journal of nutrition 2006;45(8):454-62.
2006: Irena Hainerová; Signe S Torekov; Jakob Ek; Marie Finková; Knut Borch-Johnsen; Torben Jørgensen; Ole D Madsen; Jan Lebl; Torben Hansen; Oluf Pedersen
Association between neuromedin U gene variants and overweight and obesity.
The Journal of clinical endocrinology and metabolism 2006;91(12):5057-63.
2006: Dorit P Jensen; Søren A Urhammer; Hans Eiberg; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: studies in 6018 whites.
Molecular genetics and metabolism 2006;89(4):360-7.
2006: Els C van Hove; Torben Hansen; Jacqueline M Dekker; Erwin Reiling; Giel Nijpels; Torben Jørgensen; Knut Borch-Johnsen; Yasmin H Hamid; Robert J Heine; Oluf Pedersen; J Antonie Maassen; Leen M 't Hart
The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study.
Diabetes 2006;55(11):3193-6.
2006: Signe S Torekov; Lesli H Larsen; Gitte Andersen; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects.
Diabetologia 2006;49(11):2653-8.
2006: Lise Wegner; Gitte Andersen; Anders Albrechtsen; Thomas Sparsø; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(10):1140-4.
2006: Pernille Koefoed Theil; Line Kessel; Torben Hansen; Henrik Lund-Andersen; Oluf Pedersen; Michael Larsen
Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study.
Current eye research 2006;31(9):733-8.
2006: Niels Grarup; Søren A Urhammer; Jakob Ek; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.
Diabetologia 2006;49(9):2097-104.
2006: E Feigerlová; Stepánka Pruhová; Ludmila Dittertová; Jan Lebl; D Pinterová; K Kolostová; Milena Cerná; Oluf Pedersen; Torben Hansen
Aetiological heterogeneity of asymptomatic hyperglycaemia in children and adolescents.
European journal of pediatrics 2006;165(7):446-52.
2006: Thorkild I A Sørensen; Philippe Boutin; Moira A Taylor; Lesli H Larsen; Camilla Verdich; Liselotte Petersen; Claus Holst; Søren M Echwald; Christian Dina; Søren Toubro; Martin Petersen; Jan Polak; Karine Clément; J Alfredo Martínez; Dominique Langin; Jean-Michel Oppert; Vladimir Stich; Ian Macdonald; Peter Arner; Wim H M Saris; Oluf Pedersen; Arne Astrup; philippe froguel
Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.
PLoS clinical trials 2006;1(2):e12.
2006: Jakob Ek; Sara P Hansen; Maria Lajer; Carine Nicot; Trine W Boesgaard; Stepanka Pruhova; Anders Johansen; Anders Albrechtsen; Knud Yderstraede; Jeannet Lauenborg; Marcelina Parrizas; Sylvia F Boj; Torben Jørgensen; Knut Borch-Johnsen; Peter Damm; Jorge Ferrer; Jan Lebl; Oluf Pedersen; Torben Hansen
A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.
Diabetes 2006;55(6):1869-73.
2006: Runa Louise Nolsoe; Yasmin H Hamid; Flemming Pociot; S Paulsen; K M Andersen; Knut Borch-Johnsen; Thomas Drivsholm; Torben Hansen; Oluf Pedersen; Thomas Mandrup-Poulsen
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Genes and immunity 2006;7(4):316-21.
2006: Hans Eiberg; Lars Hansen; Birgit Kjer; Torben Hansen; Oluf Pedersen; Michael Bille; Thomas Rosenberg; Lisbeth Tranebjaerg
Autosomal dominant optic atrophy associated with hearing impairment and impaired glucose regulation caused by a missense mutation in the WFS1 gene.
Journal of medical genetics 2006;43(5):435-40.
2006: Peter Rossing; Kasper Rossing; Peter Gaede; Oluf Pedersen; Hans-Henrik Parving
Monitoring kidney function in type 2 diabetic patients with incipient and overt diabetic nephropathy.
Diabetes care 2006;29(5):1024-30.
2006: Benjamin Buemann; Arne Astrup; Oluf Pedersen; Eva Black; Claus Holst; Søren Toubro; Søren M Echwald; Jens J Holst; C Rasmussen; Thorkild I A Sørensen
Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids.
The Journal of clinical endocrinology and metabolism 2006;91(5):1698-704.
2006: Claire Cheyssac; Christian Dina; frederic lepretre; Valérie Vasseur-Delannoy; Aurélie Dechaume; Stéphane Lobbens; Beverley Balkau; Juan Ruiz; Guillaume Charpentier; François Pattou; Erik Joly; Marc Prentki; Torben Hansen; Oluf Pedersen; Martine Vaxillaire; philippe froguel
EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.
Diabetes 2006;55(4):1171-6.
2006: M Petersen; M A Taylor; Wim H M Saris; Camilla Verdich; Søren Toubro; I Macdonald; S Rössner; Vladimir Stich; B Guy-Grand; Dominique Langin; J Alfredo Martinez; Oluf Pedersen; Claus Holst; Thorkild I A Sørensen; Arne Astrup
Randomized, multi-center trial of two hypo-energetic diets in obese subjects: high- versus low-fat content.
International journal of obesity (2005) 2006;30(3):552-60.
2006: Peter Gaede; Hans-Henrik Parving; Oluf Pedersen
PROactive study.
Lancet 2006;367(9504):23-4; author reply 26-7.
2006: Anders Johansen; Dorit P Jensen; Regine Bergholdt; H B Mortensen; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
Diabetes, obesity & metabolism 2006;8(1):75-82.
2006: Gitte Andersen; J Overgaard; Anders Albrechtsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes.
Diabetologia 2006;49(1):75-82.
2005: Christian Schack Rose; Jakob Ek; Søren A Urhammer; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.
Diabetes 2005;54(10):3026-31.
2005: Shekher Anuradha; Venkatesan Radha; Raj Deepa; Torben Hansen; Bendix Carstensen; Oluf Pedersen; Viswanathan Mohan
A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians.
Diabetes care 2005;28(10):2430-5.
2005: E Black; Claus Holst; Arne Astrup; Søren Toubro; Søren M Echwald; Oluf Pedersen; Thorkild I A Sørensen
Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(9):1199-205.
2005: Anders Johansen; Jakob Ek; H B Mortensen; Oluf Pedersen; Torben Hansen
Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1.
The Journal of clinical endocrinology and metabolism 2005;90(8):4607-14.
2005: Signe S Torekov; Lesli H Larsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Jens J Holst; Ole D Madsen; Torben Hansen; Oluf Pedersen
Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes.
Diabetes 2005;54(7):2261-5.
2005: Christian Schack Rose; Gitte Andersen; Yasmin H Hamid; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Studies of relationships between the GLUT10 Ala206Thr polymorphism and impaired insulin secretion.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(7):946-9.
2005: Jeannet Lauenborg; Elisabeth R Mathiesen; Torben Hansen; Charlotte Glümer; Torben Jørgensen; Knut Borch-Johnsen; Peter Hornnes; Oluf Pedersen; Peter Damm
The prevalence of the metabolic syndrome in a danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population.
The Journal of clinical endocrinology and metabolism 2005;90(7):4004-10.
2005: Thomas M Larsen; Lesli H Larsen; Signe K Torekov; Jakob Ek; Eva Black; Søren Toubro; Arne Astrup; Thorkild I A Sørensen; Torben Hansen; Oluf Pedersen
Novel variants in the putative peroxisome proliferator-activated receptor {gamma} promoter and relationships with obesity in men.
Obesity research 2005;13(6):953-8.
2005: Cathrine Lau; Kristine Faerch; Charlotte Glümer; Inge Tetens; Oluf Pedersen; Bendix Carstensen; Torben Jørgensen; Knut Borch-Johnsen
Dietary glycemic index, glycemic load, fiber, simple sugars, and insulin resistance: the Inter99 study.
Diabetes care 2005;28(6):1397-403.
2005: Leen M 't Hart; Torben Hansen; Ingrid Rietveld; Jacqueline M Dekker; Giel Nijpels; George M C Janssen; Pascal A Arp; André G Uitterlinden; Torben Jørgensen; Knut Borch-Johnsen; Huibert A P Pols; Oluf Pedersen; C.M. Duijn; Robert J Heine; J Antonie Maassen
Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.
Diabetes 2005;54(6):1892-5.
2005: Benjamin Buemann; Thorkild I A Sørensen; Oluf Pedersen; Eva Black; Claus Holst; Søren Toubro; Søren M Echwald; Jens J Holst; C Rasmussen; Arne Astrup
Lower-body fat mass as an independent marker of insulin sensitivity--the role of adiponectin.
International journal of obesity (2005) 2005;29(6):624-31.
2005: Sara K Hansen; Eva-Maria D Nielsen; Jakob Ek; Gitte Andersen; Charlotte Glümer; Bendix Carstensen; Peter Mouritzen; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(6):3629-37.
2005: Benjamin Buemann; Eva Black; Claus Holst; Søren Toubro; Søren M Echwald; Oluf Pedersen; Arne Astrup; Thorkild Sørensen
The N363S polymorphism of the glucocorticoid receptor and metabolic syndrome factors in men.
Obesity research 2005;13(5):862-7.
2005: G Andersen; Torben Hansen; Oluf Pedersen
Genetics of common forms of glycaemia with pathological impact on vascular biology: are we on the right track?
Current molecular medicine 2005;5(3):261-74.
2005: Gitte Andersen; Lise Wegner; K Yanagisawa; Christian Schack Rose; Jiandie Lin; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Bruce M Spiegelman; Oluf Pedersen
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Journal of medical genetics 2005;42(5):402-7.
2005: Ewan R Pearson; Stepanka Pruhova; C J Tack; Anders Johansen; H A J Castleden; P J Lumb; Anthony S Wierzbicki; Penny M Clark; Jan Lebl; Oluf Pedersen; Sian Ellard; Torben Hansen; Andrew T Hattersley
Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.
Diabetologia 2005;48(5):878-85.
2005: Eva-Maria D Nielsen; Lars Hansen; Trine Stissing; Keiko Yanagisawa; Knut Borch-Johnsen; Pernille Poulsen; Allan Vaag; Torben Hansen; Oluf Pedersen
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits.
Journal of molecular medicine (Berlin, Germany) 2005;83(5):353-61.
2005: Lesli H Larsen; Anette P Gjesing; Thorkild I A Sørensen; Yasmin H Hamid; Søren M Echwald; Søren Toubro; Eva Black; Arne Astrup; Torben Hansen; Oluf Pedersen
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes.
Clinical biochemistry 2005;38(5):420-4.
2005: Jakob Ek; Christian Schack Rose; Dorit P Jensen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes.
The Journal of clinical endocrinology and metabolism 2005;90(5):3054-9.
2005: Peter Gaede; Oluf Pedersen
Multi-targeted and aggressive treatment of patients with type 2 diabetes at high risk: what are we waiting for?
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37 Suppl 1():76-82.
2005: Jørn V Sagen; Ewan R Pearson; Anders Johansen; G Spyer; Oddmund Søvik; Oluf Pedersen; Pål R Njølstad; Andrew T Hattersley; Torben Hansen
Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(4):406-9.
2005: Gitte Andersen; Lise Wegner; Dorit P Jensen; Charlotte Glümer; Lise Tarnow; Thomas Drivsholm; Pernille Poulsen; Sara Kristine Hansen; Eva-Maria D Nielsen; Jakob Ek; Peter Mouritzen; Allan Vaag; Hans-Henrik Parving; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites.
Hypertension 2005;45(4):565-70.
2005: Bernadette Neve; Martin E Fernandez Zapico; Vered Ashkenazi-Katalan; Christian Dina; Yasmin H Hamid; Erik Joly; Emmanuel Vaillant; Yamina Benmezroua; Emmanuelle Durand; Nicolas Bakaher; Valérie Delannoy; Martine Vaxillaire; Tiffany Cook; Geesje M Dallinga-Thie; Hans Jansen; Marie-Aline Charles; Karine Clément; Pilar Galan; Serge Hercberg; Nicole Helbecque; Guillaume Charpentier; Marc Prentki; Torben Hansen; Oluf Pedersen; Raul Urrutia; Danielle Melloul; philippe froguel
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4807-12.
2005: Sara K Hansen; Christian Schack Rose; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen
Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.
Diabetologia 2005;48(3):452-8.
2005: Yasmin H Hamid; Søren A Urhammer; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
The common T60N polymorphism of the lymphotoxin-alpha gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome.
Diabetologia 2005;48(3):445-51.
2005: Lars Hansen; Oluf Pedersen
Genetics of type 2 diabetes mellitus: status and perspectives.
Diabetes, obesity & metabolism 2005;7(2):122-35.
2005: Yasmin H Hamid; Christian Schack Rose; Søren A Urhammer; Charlotte Glümer; Runa Louise Nolsoe; Ole P Kristiansen; Thomas Mandrup-Poulsen; Knut Borch-Johnsen; T Jorgensen; Torben Hansen; Oluf Pedersen
Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.
Diabetologia 2005;48(2):251-60.
2005: Peter Gaede; P Hildebrandt; G Hess; Hans-Henrik Parving; Oluf Pedersen
Plasma N-terminal pro-brain natriuretic peptide as a major risk marker for cardiovascular disease in patients with type 2 diabetes and microalbuminuria.
Diabetologia 2005;48(1):156-63.
2005: Yasmin H Hamid; Henrik Vissing; B Holst; Søren A Urhammer; C Pyke; Sara K Hansen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; T W Schwartz; Oluf Pedersen; Torben Hansen
Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(1):74-80.
2005: Tina Berentzen; Louise Torp Dalgaard; L Petersen; Oluf Pedersen; Thorkild I A Sørensen
Interactions between physical activity and variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight changes during a 10-y follow-up.
International journal of obesity (2005) 2005;29(1):93-9.
2005: Lesli H Larsen; Søren M Echwald; Thorkild I A Sørensen; Teis Andersen; Birgitte S Wulff; Oluf Pedersen
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity.
The Journal of clinical endocrinology and metabolism 2005;90(1):219-24.
2005: Kirstine L Andersen; Søren M Echwald; Lesli H Larsen; Yasmin H Hamid; Charlotte Glümer; Torben Jørgensen; Knut Borch-Johnsen; Teis Andersen; Thorkild I A Sørensen; Torben Hansen; Oluf Pedersen
Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity.
The Journal of clinical endocrinology and metabolism 2005;90(1):225-30.
2004: Jeannet Lauenborg; Peter Damm; Jakob Ek; Charlotte Glümer; Torben Jørgensen; Knut Borch-Johnsen; H Vestergaard; Peter Hornnes; Oluf Pedersen; Torben Hansen
Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(12):1310-5.
2004: Yasmin H Hamid; Søren A Urhammer; Dorit P Jensen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites.
Diabetes 2004;53(12):3342-5.
2004: Peter Gaede; Oluf Pedersen
Intensive integrated therapy of type 2 diabetes: implications for long-term prognosis.
Diabetes 2004;53 Suppl 3():S39-47.
2004: Gitte Andersen; Lise Wegner; Christian Schack Rose; Jianxin Xie; Hao Zhu; Kevin Larade; Anders Johansen; Jakob Ek; Jeannet Lauenborg; Thomas Drivsholm; Knut Borch-Johnsen; Peter Damm; Torben Hansen; H Franklin Bunn; Oluf Pedersen
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Diabetes 2004;53(11):2992-7.
2004: Søren M Echwald; Kirstine L Andersen; Thorkild I A Sørensen; Lesli H Larsen; Teis Andersen; Naoko Tonooka; Hideaki Tomura; Jun Takeda; Oluf Pedersen
Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity.
Human mutation 2004;24(5):381-7.
2004: Peter Gaede; Lise Tarnow; Pernille Vedel; Hans-Henrik Parving; Oluf Pedersen
Remission to normoalbuminuria during multifactorial treatment preserves kidney function in patients with type 2 diabetes and microalbuminuria.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(11):2784-8.
2004: Lars Hansen; Michael Gaster; Edward J Oakeley; Klaus Brusgaard; Eva-Maria Damsgaard Nielsen; Henning Beck-Nielsen; Oluf Pedersen; Brian A Hemmings
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes.
Biochemical and biophysical research communications 2004;323(2):685-95.
2004: Christoffer W Tornøe; Judith L Jacobsen; Oluf Pedersen; Torben Hansen; Henrik Madsen
Grey-box modelling of pharmacokinetic/pharmacodynamic systems.
Journal of pharmacokinetics and pharmacodynamics 2004;31(5):401-17.
2004: Eva-Maria D Nielsen; Lars Hansen; Maria Lajer; Kirstine L Andersen; Søren M Echwald; Søren A Urhammer; Torben Hansen; Oluf Pedersen
A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects.
Clinical biochemistry 2004;37(8):660-5.
2004: Anders Johansen; Eva-Maria D Nielsen; Gitte Andersen; Yasmin H Hamid; Dorit P Jensen; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.
Diabetologia 2004;47(8):1437-41.
2004: T Gylvin; Runa Louise Nolsoe; Torben Hansen; E M D Nielsen; Regine Bergholdt; Allan E Karlsen; Nils Billestrup; Knut Borch-Johnsen; Oluf Pedersen; Thomas Mandrup-Poulsen; Jørn Nerup; Flemming Pociot
Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.
Diabetologia 2004;47(7):1273-7.
2004: Sara K Hansen; Anette P Gjesing; Søren K Rasmussen; Charlotte Glümer; Søren A Urhammer; Gitte Andersen; Christian Schack Rose; Thomas Drivsholm; S K Torekov; Dorit P Jensen; Claus T Ekstrøm; Knut Borch-Johnsen; Torben Jørgensen; M I McCarthy; Torben Hansen; Oluf Pedersen
Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.
Diabetologia 2004;47(6):1079-87.
2004: Kurt Højlund; Torben Hansen; Maria Lajer; Jan Erik Henriksen; Klaus Levin; Jörgen Lindholm; Oluf Pedersen; Henning Beck-Nielsen
A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene.
Diabetes 2004;53(6):1592-8.
2004: Jeannet Lauenborg; Torben Hansen; Dorte Møller Jensen; Henrik Vestergaard; Lars Mølsted-Pedersen; Peter Hornnes; Henning Locht; Oluf Pedersen; Peter Damm
Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population.
Diabetes care 2004;27(5):1194-9.
2004: Frantisek Saudek; Stepánka Průhová; Petr Boucek; Jan Lebl; Milos Adamec; Jakob Ek; Oluf Pedersen; Torben Hansen
Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
Transplantation 2004;77(8):1298-301.
2004: Peter Gaede; Oluf Pedersen
Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes.
Annals of medicine 2004;36(5):355-66.
2003: Cathrine Melsæther Morberg; Inge Tetens; Eva Black; Søren Toubro; Thorkild I A Soerensen; Oluf Pedersen; Arne Astrup
Leptin and bone mineral density: a cross-sectional study in obese and nonobese men.
The Journal of clinical endocrinology and metabolism 2003;88(12):5795-800.
2003: Marie Seibaek; Henrik Vestergaard; Hans Burchardt; Carsten Sloth; Christian Torp-Pedersen; Steen Levin Nielsen; Per Hildebrandt; Oluf Pedersen
Insulin resistance and maximal oxygen uptake.
Clinical cardiology 2003;26(11):515-20.
2003: Louise Torp Dalgaard; Gitte Andersen; Lesli H Larsen; Thorkild I A Sørensen; Teis Andersen; Thomas Drivsholm; Knut Borch-Johnsen; Jan Fleckner; Torben Hansen; Nanni Din; Oluf Pedersen
Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.
Obesity research 2003;11(11):1420-7.
2003: K Yanagisawa; L Hingstrup Larsen; Gitte Andersen; Thomas Drivsholm; Anna Cederberg; Rickard Westergren; Knut Borch-Johnsen; Oluf Pedersen; Sven Enerbäck; Torben Hansen
The FOXC2 -512C>T variant is associated with hypertriglyceridaemia and increased serum C-peptide in Danish Caucasian glucose-tolerant subjects.
Diabetologia 2003;46(11):1576-80.
2003: Gitte Andersen; Christian Schack Rose; Yasmin H Hamid; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits.
Diabetes 2003;52(9):2445-8.
2003: Oluf Pedersen; Peter Gaede
Intensified multifactorial intervention and cardiovascular outcome in type 2 diabetes: the Steno-2 study.
Metabolism: clinical and experimental 2003;52(8 Suppl 1):19-23.
2003: Eva-Maria D Nielsen; Lars Hansen; Søren M Echwald; Thomas Drivsholm; Knut Borch-Johnsen; Claus T Ekstrøm; Torben Hansen; Oluf Pedersen
Evidence for an association between the Leu162Val polymorphism of the PPARalpha gene and decreased fasting serum triglyceride levels in glucose tolerant subjects.
Pharmacogenetics 2003;13(7):417-23.
2003: J Pildal; Maria Lajer; Sara K Hansen; Katrine Almind; Louise Ambye; Knut Borch-Johnsen; Bendix Carstensen; Torben Hansen; Oluf Pedersen
Studies of variability in the islet amyloid polypeptide gene in relation to Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2003;20(6):491-4.
2003: Yunhua Li Muller; Clifton Bogardus; Oluf Pedersen; Leslie J Baier
A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.
Diabetes 2003;52(3):895-8.
2003: Timothy M Frayling; Cecilia M Lindgren; Jean Claude Chevre; Stephan Menzel; Marie Wishart; Yamina Benmezroua; Alison Brown; Julie C Evans; Pamidghantam Subba Rao; Christian Dina; Cécile Lecoeur; Timo Kanninen; Peter Almgren; Michael P Bulman; Youxiang Wang; James Mills; Rosemarie Wright-Pascoe; Melanie M Mahtani; Francesco Prisco; Angels Costa; Ignacio Cognet; Torben Hansen; Oluf Pedersen; Sian Ellard; Tiinamaija Tuomi; Leif C Groop; philippe froguel; Andrew T Hattersley; Martine Vaxillaire
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Diabetes 2003;52(3):872-81.
2003: Peter Gaede; Henrik Post Hansen; Hans-Henrik Parving; Oluf Pedersen
Impact of low-dose acetylsalicylic acid on kidney function in type 2 diabetic patients with elevated urinary albumin excretion rate.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(3):539-42.
2003: Stepanka Pruhova; Jakob Ek; Jan Lebl; Zdenek Sumnik; Frantisek Saudek; Michal Andel; Oluf Pedersen; Torben Hansen
Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha.
Diabetologia 2003;46(2):291-5.
2003: Eva-Maria D Nielsen; Lars Hansen; Bendix Carstensen; Søren M Echwald; Thomas Drivsholm; Charlotte Glümer; Birger Thorsteinsson; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.
Diabetes 2003;52(2):573-7.
2003: Peter Gaede; Pernille Vedel; Nicolai Larsen; Gunnar V H Jensen; Hans-Henrik Parving; Oluf Pedersen
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.
The New England journal of medicine 2003;348(5):383-93.
2003: Pernille Poulsen; Gitte Andersen; Mogens Fenger; Torben Hansen; Søren M Echwald; Aage Voelund; Henning Beck-Nielsen; Oluf Pedersen; Allan Vaag
Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?
Diabetes 2003;52(1):194-8.
2002: Søren K Rasmussen; Søren A Urhammer; Lars Berglund; Jan N Jensen; Lars Hansen; Søren M Echwald; Knut Borch-Johnsen; Yukio Horikawa; Hirosato Mashima; Hans Lithell; Nancy J Cox; Torben Hansen; Graeme I Bell; Oluf Pedersen
Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.
Diabetes 2002;51(12):3561-7.
2002: Sara K Hansen; Marcelina Parrizas; Maria L Jensen; Stepanka Pruhova; Jakob Ek; Sylvia F Boj; Anders Johansen; Miguel A Maestro; Francisca Rivera; Hans Eiberg; Michal Andel; Jan Lebl; Oluf Pedersen; Jorge Ferrer; Torben Hansen
Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.
The Journal of clinical investigation 2002;110(6):827-33.
2002: Peter Jacobsen; Niels Grarup; Lise Tarnow; Hans-Henrik Parving; Oluf Pedersen
PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17(8):1408-12.
2002: Esben S Buhl; Niels Jessen; Rasmus Pold; Thomas Ledet; Allan Flyvbjerg; Steen Pedersen; Oluf Pedersen; Ole Schmitz; Sten Lund
Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome.
Diabetes 2002;51(7):2199-206.
2002: Amanda Stride; Martine Vaxillaire; Tiinamaija Tuomi; Fabrizio Barbetti; Pål R Njølstad; Torben Hansen; Angels Costa; I Conget; Oluf Pedersen; Oddmund Søvik; Renata Lorini; L Groop; philippe froguel; Andrew T Hattersley
The genetic abnormality in the beta cell determines the response to an oral glucose load.
Diabetologia 2002;45(3):427-35.
2002: Katrine Almind; Laurent Delahaye; Torben Hansen; Emmanuel Van Obberghen; Oluf Pedersen; C Ronald Kahn
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2124-8.
2002: Eva Black; Liselotte Petersen; Martin Kreutzer; Søren Toubro; Thorkild I A Sørensen; Oluf Pedersen; Arne Astrup
Fat mass measured by DXA varies with scan velocity.
Obesity research 2002;10(2):69-77.
2002: Søren M Echwald; Helle Bach; Henrik Vestergaard; Bjørn Richelsen; Kurt Kristensen; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.
Diabetes 2002;51(1):1-6.
2001: Jakob Ek; Gitte Andersen; Søren A Urhammer; P H Gaede; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus.
Diabetologia 2001;44(12):2220-6.
2001: H Vestergaard; S Lund; Oluf Pedersen
Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism.
Journal of internal medicine 2001;250(5):406-14.
2001: Torben Hansen; Louise Ambye; N Grarup; Lars Hansen; Søren M Echwald; J Ferrer; Oluf Pedersen
Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus.
Diabetologia 2001;44(10):1330-4.
2001: Søren M Echwald; Thorkild I A Sørensen; Teis Andersen; Oluf Pedersen
The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(10):1563-5.
2001: Jakob Ek; Niels Grarup; Søren A Urhammer; P H Gaede; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Studies of the variability of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function.
Human mutation 2001;18(4):356-7.
2001: Peter Gaede; Pernille Vedel; Hans-Henrik Parving; Oluf Pedersen
Elevated levels of plasma von Willebrand factor and the risk of macro- and microvascular disease in type 2 diabetic patients with microalbuminuria.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(10):2028-33.
2001: Peter Gaede; H E Poulsen; Hans-Henrik Parving; Oluf Pedersen
Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(9):756-60.
2001: Jakob Ek; Gitte Andersen; Søren A Urhammer; Lars Hansen; Bendix Carstensen; Knut Borch-Johnsen; Thomas Drivsholm; Lars Berglund; Torben Hansen; Hans Lithell; Oluf Pedersen
Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant caucasians.
Diabetologia 2001;44(9):1170-6.
2001: Louise Torp Dalgaard; Torben Hansen; Søren A Urhammer; Thomas Drivsholm; Knut Borch-Johnsen; Oluf Pedersen
The uncoupling protein 3 -55 C -->T variant is not associated with Type II diabetes mellitus in Danish subjects.
Diabetologia 2001;44(8):1065-7.
2001: Louise Torp Dalgaard; Oluf Pedersen
Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.
Diabetologia 2001;44(8):946-65.
2001: Lise Tarnow; Niels Grarup; Torben Hansen; Hans-Henrik Parving; Oluf Pedersen
Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(8):1653-6.
2001: AM Møller; N M Jensen; J Pildal; Thomas Drivsholm; Knut Borch-Johnsen; Søren A Urhammer; Torben Hansen; Oluf Pedersen
Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2001;86(5):2181-6.
2001: Benjamin Buemann; B Schierning; Søren Toubro; B M Bibby; Thorkild Sørensen; Louise Torp Dalgaard; Oluf Pedersen; Arne Astrup
The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(4):467-71.
2001: Louise Torp Dalgaard; Thorkild I A Sørensen; Thomas Drivsholm; Knut Borch-Johnsen; Teis Andersen; Torben Hansen; Oluf Pedersen
A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population.
The Journal of clinical endocrinology and metabolism 2001;86(3):1398-402.
2001: Lars Hansen; Jan N Jensen; Claus T Ekstrøm; Henrik Vestergaard; Torben Hansen; Oluf Pedersen
Studies of variability in the PTEN gene among Danish caucasian patients with Type II diabetes mellitus.
Diabetologia 2001;44(2):237-40.
2001: Peter Gaede; M Beck; Pernille Vedel; Oluf Pedersen
Limited impact of lifestyle education in patients with Type 2 diabetes mellitus and microalbuminuria: results from a randomized intervention study.
Diabetic medicine : a journal of the British Diabetic Association 2001;18(2):104-8.
2001: Jan N Jensen; Lars Hansen; Claus T Ekstrøm; Flemming Pociot; J Nerup; Torben Hansen; Oluf Pedersen
Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation to altered insulin secretion and diabetes in the Danish Caucasian population.
Diabetologia 2001;44(1):123-6.
2001: Esben S Buhl; Niels Jessen; Ole Schmitz; Steen Pedersen; Oluf Pedersen; G D Holman; Sten Lund
Chronic treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT4 translocation in rat skeletal muscles in a fiber type-specific manner.
Diabetes 2001;50(1):12-7.
2000: Søren A Urhammer; Torben Hansen; Knut Borch-Johnsen; Oluf Pedersen
Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects.
The Journal of clinical endocrinology and metabolism 2000;85(9):3151-4.
2000: Søren K Rasmussen; Søren A Urhammer; A Pizzuti; Søren M Echwald; Claus T Ekstrøm; Lars Hansen; Torben Hansen; Knut Borch-Johnsen; L Frittitta; V Trischitta; Oluf Pedersen
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.
Diabetes 2000;49(9):1608-11.
2000: Søren K Rasmussen; Søren A Urhammer; Torben Hansen; Katrine Almind; AM Møller; Knut Borch-Johnsen; Oluf Pedersen
Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects.
The Journal of clinical endocrinology and metabolism 2000;85(8):2951-3.
2000: S K Rasmussen; L Hansen; EU Frevert; P T Cohen; Barbara B Kahn; Oluf Pedersen
Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes.
Diabetologia 2000;43(6):718-22.
2000: L Hansen; Jan N Jensen; S Urioste; Helle Vestergaard Petersen; Flemming Pociot; Hans Eiberg; O P Kristiansen; Torben Hansen; Palle Serup; J Nerup; Oluf Pedersen
NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.
Diabetes 2000;49(5):876-8.
2000: Søren K Rasmussen; Søren A Urhammer; Jan N Jensen; Torben Hansen; Knut Borch-Johnsen; Oluf Pedersen
The -238 and -308 G-->A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians.
The Journal of clinical endocrinology and metabolism 2000;85(4):1731-4.
2000: Søren K Rasmussen; Corinne Lautier; Lars Hansen; Søren M Echwald; Torben Hansen; Claus T Ekstrøm; Søren A Urhammer; Knut Borch-Johnsen; FLORIN GRIGORESCU; R J Smith; Oluf Pedersen
Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2000;85(4):1606-10.
2000: L Hansen; S Urioste; Helle Vestergaard Petersen; Jan N Jensen; Hans Eiberg; F Barbetti; Palle Serup; Torben Hansen; Oluf Pedersen
Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians.
The Journal of clinical endocrinology and metabolism 2000;85(3):1323-6.
2000: Lars Hansen; R Reneland; Lars Berglund; Søren K Rasmussen; Torben Hansen; Hans Lithell; Oluf Pedersen
Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.
Diabetes 2000;49(2):298-301.
1999: Louise Torp Dalgaard; Thorkild I A Sørensen; Teis Andersen; Torben Hansen; Oluf Pedersen
An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men.
Diabetologia 1999;42(12):1413-6.
1999: Wim Derave; Sten Lund; G D Holman; Jørgen F P Wojtaszewski; Oluf Pedersen; Erik A Richter
Contraction-stimulated muscle glucose transport and GLUT-4 surface content are dependent on glycogen content.
The American journal of physiology 1999;277(6 Pt 1):E1103-10.
1999: Søren M Echwald; Thorkild I A Sørensen; Teis Andersen; C Hansen; Niels Tommerup; Oluf Pedersen
Sequence variants in the human cocaine and amphetamine-regulated transcript (CART) gene in subjects with early onset obesity.
Obesity research 1999;7(6):532-6.
1999: Arne Astrup; Søren Toubro; Louise Torp Dalgaard; S A Urhammer; T I Sorensen; Oluf Pedersen
Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23(10):1030-4.
1999: Katrine Almind; S K Frederiksen; Dolores Bernal; Torben Hansen; Louise Ambye; Søren A Urhammer; C T Ekstrøm; Lars Berglund; R Reneland; H Lithell; Morris F White; Emmanuel Van Obberghen; Oluf Pedersen
Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity.
Diabetologia 1999;42(10):1244-9.
1999: AM Møller; Jakob Ek; S M Durviaux; Søren A Urhammer; JO Clausen; Hans Eiberg; Torben Hansen; G G Rousseau; Frédéric P Lemaigre; Oluf Pedersen
Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.
Diabetologia 1999;42(8):1011-6.
1999: Jakob Ek; Søren A Urhammer; Thorkild I A Sørensen; Teis Andersen; J Auwerx; Oluf Pedersen
Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men.
Diabetologia 1999;42(7):892-5.
1999: Katrine Almind; M G Ahlgren; Torben Hansen; Søren A Urhammer; JO Clausen; Oluf Pedersen
Discovery of a Met300Val variant in Shc and studies of its relationship to birth weight and length, impaired insulin secretion, insulin resistance, and type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1999;84(6):2241-4.
1999: Lise Tarnow; S A Urhammer; B Mottlau; Birgitte V Hansen; Oluf Pedersen; Hans-Henrik Parving
The Trp64Arg amino acid polymorphism of the beta3-adrenergic receptor gene does not contribute to the genetic susceptibility of diabetic microvascular complications in Caucasian type 1 diabetic patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999;14(4):895-7.
1999: Marju Orho-Melander; H Shimomura; T Sanke; S K Rasmussen; K Nanjo; Oluf Pedersen; Leif C Groop
Expression of naturally occurring variants in the muscle glycogen synthase gene.
Diabetes 1999;48(4):918-20.
1999: Louise Torp Dalgaard; Torben Hansen; Søren A Urhammer; JO Clausen; Hans Eiberg; Oluf Pedersen
Intermediate expansions of a GAA repeat in the frataxin gene are not associated with type 2 diabetes or altered glucose-induced beta-cell function in Danish Caucasians.
Diabetes 1999;48(4):914-7.
1999: Søren M Echwald; Thorkild I A Sørensen; Teis Andersen; A Tybjaerg-Hansen; JO Clausen; Oluf Pedersen
Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23(3):293-8.
1999: Peter Gaede; Pernille Vedel; Hans-Henrik Parving; Oluf Pedersen
Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study.
Lancet 1999;353(9153):617-22.
1999: Lars Hansen; H Fjordvang; Søren K Rasmussen; Henrik Vestergaard; Søren M Echwald; Torben Hansen; D Alessi; Shirish Shenolikar; Alan Saltiel; F Barbetti; Oluf Pedersen
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
Diabetes 1999;48(2):403-7.
1999: AM Møller; Louise Torp Dalgaard; Louise Ambye; Lars Hansen; O Schmitz; Torben Hansen; Oluf Pedersen
A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young.
The Journal of clinical endocrinology and metabolism 1999;84(1):367-9.
1998: AM Møller; Louise Torp Dalgaard; Flemming Pociot; Jørn Nerup; Torben Hansen; Oluf Pedersen
Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.
Diabetologia 1998;41(12):1528-31.
1998: Søren A Urhammer; Torben Hansen; Claus T Ekstrøm; Hans Eiberg; Oluf Pedersen
The Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: evidence from studies of 231 glucose-tolerant first degree relatives of type 2 diabetic probands.
The Journal of clinical endocrinology and metabolism 1998;83(12):4506-9.
1998: Søren A Urhammer; AM Møller; B Nyholm; Claus T Ekstrøm; Hans Eiberg; JO Clausen; Torben Hansen; Oluf Pedersen; O Schmitz
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 1998;83(11):3992-5.
1998: Katrine Almind; Louise Ambye; Søren A Urhammer; Torben Hansen; Søren M Echwald; J J Holst; J Gromada; B Thorens; Oluf Pedersen
Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.
Diabetologia 1998;41(10):1194-8.
1998: Søren M Echwald; Thorkild I A Sørensen; A Tybjaerg-Hansen; Teis Andersen; Oluf Pedersen
Gln27Glu variant of the human beta2-adrenoreceptor gene is not associated with early-onset obesity in Danish men.
Diabetes 1998;47(10):1657-8.
1998: Katrine Almind; S K Frederiksen; M G Ahlgren; Søren A Urhammer; Torben Hansen; JO Clausen; Oluf Pedersen
Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance.
Diabetologia 1998;41(8):969-74.
1998: Søren A Urhammer; Torben Hansen; JO Clausen; Hans Eiberg; Oluf Pedersen
The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians.
Diabetes 1998;47(8):1359-61.
1998: Dolores Bernal; Katrine Almind; Lynne Yenush; M Ayoub; Y Zhang; L Rosshani; C Larsson; Oluf Pedersen; Morris F White
Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians.
Diabetes 1998;47(6):976-9.
1998: Torben Hansen; Søren M Echwald; Lars Hansen; AM Møller; Katrine Almind; JO Clausen; Søren A Urhammer; H Inoue; Jorge Ferrer; J Bryan; Lydia Aguilar-Bryan; M Alan Permutt; Oluf Pedersen
Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.
Diabetes 1998;47(4):598-605.
1998: Søren A Urhammer; Louise Torp Dalgaard; Thorkild I A Sørensen; A Tybjaerg-Hansen; Søren M Echwald; Teis Andersen; JO Clausen; Oluf Pedersen
Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity.
Diabetologia 1998;41(2):241-4.
1997: Søren A Urhammer; M Fridberg; Thorkild I A Sørensen; Søren M Echwald; Teis Andersen; A Tybjaerg-Hansen; JO Clausen; Oluf Pedersen
Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity.
The Journal of clinical endocrinology and metabolism 1997;82(12):4069-74.
1997: Søren A Urhammer; Louise Torp Dalgaard; Thorkild I A Sørensen; AM Møller; Teis Andersen; A Tybjaerg-Hansen; Torben Hansen; JO Clausen; Henrik Vestergaard; Oluf Pedersen
Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.
Diabetologia 1997;40(10):1227-30.
1997: AM Møller; Søren A Urhammer; Louise Torp Dalgaard; R Reneland; Lars Berglund; Torben Hansen; JO Clausen; Hans Lithell; Oluf Pedersen
Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM.
Diabetologia 1997;40(8):980-3.
1997: Lars Hansen; K C Arden; S B Rasmussen; Carrie Viars; Henrik Vestergaard; Torben Hansen; AM Møller; J R Woodgett; Oluf Pedersen
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3alpha and beta isoforms in patients with NIDDM.
Diabetologia 1997;40(8):940-6.
1997: Marie Seibaek; C Sloth; L Vallebo; T Hansen; S A Urhammer; Hans Burchardt; Christian Torp-Pedersen; Oluf Pedersen; Per Hildebrandt
Glucose tolerance status and severity of coronary artery disease in men referred to coronary arteriography.
American heart journal 1997;133(6):622-9.
1997: Lars Hansen; Torben Hansen; JO Clausen; Søren M Echwald; Søren A Urhammer; Søren K Rasmussen; Oluf Pedersen
The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance.
American journal of human genetics 1997;60(6):1532-5.
1997: Søren A Urhammer; Torben Hansen; L B Jensen; JO Clausen; Lars Hansen; K C Chui; Oluf Pedersen
Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.
The Journal of clinical endocrinology and metabolism 1997;82(6):1786-9.
1997: Henrik Vestergaard; M Rossen; Søren A Urhammer; J Müller; Oluf Pedersen
Short- and long-term metabolic effects of recombinant human IGF-I treatment in patients with severe insulin resistance and diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(5):475-82.
1997: E Christiansen; S Schnider; B Palmvig; Ellis Tauber-Lassen; Oluf Pedersen
Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM.
Diabetes care 1997;20(5):881-7.
1997: Flemming S Nielsen; Peter Gaede; Pernille Vedel; Oluf Pedersen; Hans-Henrik Parving
White coat hypertension in NIDDM patients with and without incipient and overt diabetic nephropathy.
Diabetes care 1997;20(5):859-63.
1997: Søren A Urhammer; M Fridberg; Torben Hansen; Søren K Rasmussen; AM Møller; JO Clausen; Oluf Pedersen
A prevalent amino acid polymorphism at codon 98 in the hepatocyte nuclear factor-1alpha gene is associated with reduced serum C-peptide and insulin responses to an oral glucose challenge.
Diabetes 1997;46(5):912-6.
1997: Søren M Echwald; T D Sørensen; Thorkild I A Sørensen; A Tybjaerg-Hansen; Teis Andersen; Wendy Chung; R L Leibel; Oluf Pedersen
Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.
Biochemical and biophysical research communications 1997;233(1):248-52.
1997: Søren M Echwald; S B Rasmussen; Thorkild I A Sørensen; Teis Andersen; A Tybjaerg-Hansen; JO Clausen; Lars Hansen; T Hansen; Oluf Pedersen
Identification of two novel missense mutations in the human OB gene.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(4):321-6.
1997: Søren A Urhammer; Søren K Rasmussen; P J Kaisaki; N Oda; K Yamagata; AM Møller; M Fridberg; Lars Hansen; Torben Hansen; Graeme I Bell; Oluf Pedersen
Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.
Diabetologia 1997;40(4):473-5.
1997: Torben Hansen; H Eiberg; M Rouard; Martine Vaxillaire; AM Møller; Søren K Rasmussen; M Fridberg; Søren A Urhammer; J J Holst; Katrine Almind; Søren M Echwald; Lars Hansen; Graeme I Bell; Oluf Pedersen
Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
Diabetes 1997;46(4):726-30.
1997: Lars Hansen; Søren M Echwald; T Hansen; Søren A Urhammer; JO Clausen; Oluf Pedersen
Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.
Diabetes 1997;46(3):508-12.
1997: Torben Hansen; C B Andersen; Søren M Echwald; Søren A Urhammer; JO Clausen; Henrik Vestergaard; D Owens; Lars Hansen; Oluf Pedersen
Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.
Diabetes 1997;46(3):494-501.
1996: K Yamagata; Naohisa Oda; Pamela J Kaisaki; Stephan Menzel; H Furuta; Martine Vaxillaire; L Southam; R D Cox; G Mark Lathrop; V V Boriraj; X Chen; Nancy J Cox; Y Oda; H Yano; Michelle M Le Beau; S Yamada; H Nishigori; J Takeda; SS Fajans; Andrew T Hattersley; Naoko Iwasaki; Torben Hansen; Oluf Pedersen; Kenneth S Polonsky; Graeme I Bell
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
Nature 1996;384(6608):455-8.
1996: P Koefoed Theil; Torben Hansen; Michael Larsen; Oluf Pedersen; Henrik Lund-Andersen
Lens autofluorescence is increased in newly diagnosed patients with NIDDM.
Diabetologia 1996;39(12):1524-7.
1996: E Christiansen; A Tibell; A Vølund; Knud Rasmussen; C G Groth; Jens Juul Holst; Oluf Pedersen; Niels Juel Christensen; Sten Madsbad
Pancreatic endocrine function in recipients of segmental and whole pancreas transplantation.
The Journal of clinical endocrinology and metabolism 1996;81(11):3972-9.
1996: JO Clausen; K Borch-Johnsen; H Ibsen; R N Bergman; Philip Hougaard; K Winther; Oluf Pedersen
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors.
The Journal of clinical investigation 1996;98(5):1195-209.
1996: Søren A Urhammer; JO Clausen; Torben Hansen; Oluf Pedersen
Insulin sensitivity and body weight changes in young white carriers of the codon 64 amino acid polymorphism of the beta 3-adrenergic receptor gene.
Diabetes 1996;45(8):1115-20.
1996: Katrine Almind; G Inoue; Oluf Pedersen; C Ronald Kahn
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.
The Journal of clinical investigation 1996;97(11):2569-75.
1995: Henrik Vestergaard; C Bjørbaek; Torben Hansen; F S Larsen; D K Granner; Oluf Pedersen
Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients.
The Journal of clinical investigation 1995;96(6):2639-45.
1995: Henrik Vestergaard; S Lund; C Bjørbaek; Oluf Pedersen
Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control.
Diabetologia 1995;38(10):1230-8.
1995: Lars Hansen; Torben Hansen; Henrik Vestergaard; C Bjørbaek; Søren M Echwald; JO Clausen; Y H Chen; M X Chen; P T Cohen; Oluf Pedersen
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin.
Human molecular genetics 1995;4(8):1313-20.
1995: Henrik Vestergaard; Peter Skøtt; R Steffensen; H Wroblewski; Oluf Pedersen; J Kastrup
Insulin-resistant glucose metabolism in patients with microvascular angina--syndrome X.
Metabolism: clinical and experimental 1995;44(7):876-82.
1995: Henrik Vestergaard; H H Klein; Torben Hansen; J Müller; F Skovby; C Bjørbaek; ME Røder; Oluf Pedersen
Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy.
The Journal of clinical investigation 1995;95(4):1925-32.
1995: Søren M Echwald; C Bjørbaek; Torben Hansen; JO Clausen; Henrik Vestergaard; J R Zierath; R L Printz; D K Granner; Oluf Pedersen
Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.
Diabetes 1995;44(3):347-53.
1995: Henrik Vestergaard; H H Parving; Lars Hansen; Oluf Pedersen
Whole-body glucose metabolism in obese patients with type 2 diabetes mellitus: the impact of hypertension and strict blood glucose control.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(2):156-63.
1995: Henrik Vestergaard; J E Weinreb; A S Rosen; C Bjørbaek; Lars Hansen; Oluf Pedersen; Barbara B Kahn
Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study.
The Journal of clinical endocrinology and metabolism 1995;80(1):270-5.
1994: Y H Chen; Lars Hansen; M X Chen; C Bjørbaek; Henrik Vestergaard; Torben Hansen; Patricia T W Cohen; Oluf Pedersen
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM.
Diabetes 1994;43(10):1234-41.
1994: Oluf Pedersen; L Hansen; J F Bak
Impaired glycogen synthesis of skeletal muscle in patients with insulin-resistant diabetes mellitus.
Journal of diabetes and its complications 1994;8(4):213-20.
1994: C Bjørbaek; Søren M Echwald; P Hubricht; Henrik Vestergaard; Torben Hansen; J Zierath; Oluf Pedersen
Genetic variants in promoters and coding regions of the muscle glycogen synthase and the insulin-responsive GLUT4 genes in NIDDM.
Diabetes 1994;43(8):976-83.
1994: E Christiansen; A Tibell; C G Groth; K Rasmussen; Oluf Pedersen; Flemming Burcharth; Niels Juel Christensen; A Vølund; Sten Madsbad
Limitations in the use of insulin or C-peptide alone in the assessment of beta-cell function in pancreas transplant recipients. Danish-Swedish Study Group of Metabolic Effect of Pancreas Transplantation.
Transplantation proceedings 1994;26(2):467-8.
1994: Henrik Vestergaard; P H Andersen; S Lund; P Vedel; Oluf Pedersen
Expression of glycogen synthase and phosphofructokinase in muscle from type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment.
Diabetologia 1994;37(1):82-90.
1993: Torben Hansen; C Bjørbaek; Henrik Vestergaard; K Grønskov; J F Bak; Oluf Pedersen
Expression of insulin receptor spliced variants and their functional correlates in muscle from patients with non-insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1993;77(6):1500-5.
1993: Katrine Almind; C Bjørbaek; Henrik Vestergaard; Torben Hansen; Søren M Echwald; Oluf Pedersen
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.
Lancet 1993;342(8875):828-32.
1993: Bente Stallknecht; P H Andersen; Jørgen Vinten; Lars Bendtsen; J Sibbersen; Oluf Pedersen; Henrik Galbo
Effect of physical training on glucose transporter protein and mRNA levels in rat adipocytes.
The American journal of physiology 1993;265(1 Pt 1):E128-34.
1993: Henrik Vestergaard; S Lund; F S Larsen; O J Bjerrum; Oluf Pedersen
Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1993;91(6):2342-50.
1991: Henrik Vestergaard; C Bjørbaek; P H Andersen; J F Bak; Oluf Pedersen
Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients.
Diabetes 1991;40(12):1740-5.
1990: Thorkil Ploug; Bente Stallknecht; Oluf Pedersen; B B Kahn; T Ohkuwa; Jørgen Vinten; Henrik Galbo
Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle.
The American journal of physiology 1990;259(6 Pt 1):E778-86.