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Stine Pedersen

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Chemicals & Drugs

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Ehrlich Tumor Carcinoma

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Signal Transduction

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Ebbe Boedtkjer; Peer M Christiansen; Vibeke E D Jensen; Marco Mele; José M A Moreira; Stine F Pedersen; Pernille Vahl; Vera T Wielenga; Christian Aalkjaer
Contribution of Na+,HCO3(-)-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7).
Ditte L Clement; Mette Lethan; Sabine Mally; Stine F Pedersen; Peter Satir; Albrecht Schwab; Christian Stock; Søren T Christensen
PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways.
Donald L Ly; András Masszi; Hiroyasu Nakano; Stine F Pedersen; Pam Speight; Katalin Szászi; Faiza Waheed; Maria Hersom; Monika Lodyga; Andras Kapus
Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton.

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2013: Ebbe Boedtkjer; Peer M Christiansen; Vibeke E D Jensen; Marco Mele; José M A Moreira; Stine F Pedersen; Pernille Vahl; Vera T Wielenga; Christian Aalkjaer
Contribution of Na+,HCO3(-)-cotransport to cellular pH control in human breast cancer: a role for the breast cancer susceptibility locus NBCn1 (SLC4A7).
International journal of cancer. Journal international du cancer 2013;132(6):1288-99.
2013: Ditte L Clement; Mette Lethan; Sabine Mally; Stine F Pedersen; Peter Satir; Albrecht Schwab; Christian Stock; Søren T Christensen
PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways.
Journal of cell science 2013;126(Pt 4):953-65.
2013: Donald L Ly; András Masszi; Hiroyasu Nakano; Stine F Pedersen; Pam Speight; Katalin Szászi; Faiza Waheed; Maria Hersom; Monika Lodyga; Andras Kapus
Hyperosmotic stress regulates the distribution and stability of myocardin-related transcription factor, a key modulator of the cytoskeleton.
American journal of physiology. Cell physiology 2013;304(2):C115-27.
2013: Iben R Veland; Lorraine Eley; Judith Goodship; Karsten Kristiansen; Rodrick Montjean; Lotte B Pedersen; Stine F Pedersen; Sophie Saunier; Albrecht Schwab; Søren T Christensen
Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration.
PloS one 2013;8(4):e60193.
2012: Ann M Larsen; Gitte Lauritzen; Christina W Olesen; Stine F Pedersen; Ebbe Boedtkjer; Steen Honoré Hansen; Niels Krogsgaard-Larsen; Lennart Bunch
Gram-scale solution-phase synthesis of selective sodium bicarbonate co-transport inhibitor S0859: in vitro efficacy studies in breast cancer cells.
ChemMedChem 2012;7(10):1808-14.
2012: C P Madsen; Stine F Pedersen; A Fabian; B J Hansen; T K Klausen; Else Hoffmann
On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle.
American journal of physiology. Cell physiology 2012;303(6):C625-34.
2012: Gitte Lauritzen; Justine Lemaire; Stine F Lund; Katrine Seide Petersen; Lone Rønnov-Jessen; Albrecht Schwab; Christian-Martin Stock; Maria Wiwel; Britt Damsgaard; Mie Frid Jensen; Stine F Pedersen
The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2.
Cancer letters 2012;317(2):172-83.
2012: Ebbe Boedtkjer; Lennart Bunch; Stine F Pedersen
Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy.
Current pharmaceutical design 2012;18(10):1345-71.
2011: Andrej Gorbatenko; András Kapus; Henrik Klingberg; Anni Bech Nielsen; Maria Wiwel; Stine F Pedersen
Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in Ehrlich Lettré Ascites cells through a mechanism involving p38 mitogen-activated protein kinase.
Journal of cellular physiology 2011;226(11):2857-68.
2011: Stine F Pedersen; András Kapus; Else K Hoffmann
Osmosensory mechanisms in cellular and systemic volume regulation.
Journal of the American Society of Nephrology : JASN 2011;22(9):1587-97.
2011: Jacob M Schrøder; Rikke I Thorsteinsson; Stine F Pedersen; Anna Akhmanova; Søren T Christensen; Stefan Geimer; Ilya Grigoriev; Yulia Komarova; Jesper Larsen; Robert Manguso; Lotte B Pedersen
EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms.
Journal of cell science 2011;124(Pt 15):2539-51.
2011: Else Hoffmann; Stine F Pedersen
Cell volume homeostatic mechanisms: effectors and signalling pathways.
Acta physiologica (Oxford, England) 2011;202(3):465-85.
2011: Ann-Beth Nørholm; Ruth Hendus-Altenburger; Gabriel Bjerre; Magnus Kjaergaard; Stine F Pedersen; Birthe Kragelund
The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking.
Biochemistry 2011;50(17):3469-80.
2011: Christine Martin; Stine F Pedersen; Albrecht Schwab; Christian Stock
Intracellular pH gradients in migrating cells.
American journal of physiology. Cell physiology 2011;300(3):C490-5.
2011: Eva B Nygaard; Jens O Lagerstedt; Gabriel Bjerre; Biao Shi; Madhu Budamagunta; Kristian A Poulsen; Stine Meinild; Robert R Rigor; John C Voss; Peter M Cala; Stine F Pedersen
Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1.
The Journal of biological chemistry 2011;286(1):634-48.
2011: Ann-Dorit Andersen; Bo Hjorth Bentzen; Morten Grunnet; Morten Kanneworff; Henrik Klingberg; Henrik Salling; Stine F Pedersen
The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;28(1):13-24.
2010: G Lauritzen; M B F Jensen; Ebbe Boedtkjer; R Dybboe; C Aalkjaer; Jesper Nylandsted; Stine F Pedersen
NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance.
Experimental cell research 2010;316(15):2538-53.
2010: Thomas Kjaer Klausen; Sarah Preisler; Stine F Pedersen; Else Hoffmann
Monovalent ions control proliferation of Ehrlich Lettre ascites cells.
American journal of physiology. Cell physiology 2010;299(3):C714-25.
2010: Magnus Kjaergaard; Ann-Beth Nørholm; Ruth Hendus-Altenburger; Stine F Pedersen; Flemming M Poulsen; Birthe Kragelund
Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?
Protein science : a publication of the Protein Society 2010;19(8):1555-64.
2009: Ana C P Thirone; Pam Speight; Matthew Zulys; Ori D Rotstein; Katalin Szászi; Stine F Pedersen; Andras Kapus
Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response.
American journal of physiology. Cell physiology 2009;296(3):C463-75.
2009: Else K Hoffmann; Ian H Lambert; Stine F Pedersen
Physiology of cell volume regulation in vertebrates.
Physiological reviews 2009;89(1):193-277.
2008: Linda Schneider; Thomas K Klausen; Christian Stock; Sabine Mally; Søren T Christensen; Stine F Pedersen; Else Hoffmann; Albrecht Schwab
H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.
Pflügers Archiv : European journal of physiology 2008;455(6):1055-62.
2008: Søren T Christensen; Stine F Pedersen; Peter Satir; Iben R Veland; Linda Schneider
The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair.
Current topics in developmental biology 2008;85():261-301.
2008: Maria Rasmussen; R Todd Alexander; Barbara V Darborg; Nadja Møbjerg; Else Hoffmann; András Kapus; Stine F Pedersen
Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.
American journal of physiology. Cell physiology 2008;294(1):C197-212.
2007: Kristian A Poulsen; Stine F Pedersen; Miriam Kolko; Ian H Lambert
Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants.
American journal of physiology. Cell physiology 2007;293(5):C1605-15.
2007: Stine F Pedersen; Scott A King; Eva B Nygaard; Robert R Rigor; Peter M Cala
NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity.
The Journal of biological chemistry 2007;282(27):19716-27.
2007: Maria L Rentsch; Carlo G Ossum; Else Hoffmann; Stine F Pedersen
Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.
Pflügers Archiv : European journal of physiology 2007;454(4):649-62.
2007: Stine F Pedersen; Barbara Vasek Darborg; Maria Louise Rentsch; Maria Rasmussen
Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.
Archives of biochemistry and biophysics 2007;462(2):195-201.
2007: Else Hoffmann; Stine F Pedersen
Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells.
American journal of physiology. Cell physiology 2007;292(5):C1854-66.
2007: Thomas Kjaer Klausen; Andreas Bergdahl; Charlotte Hougaard; palle christophersen; Stine F Pedersen; Else Hoffmann
Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells.
Journal of cellular physiology 2007;210(3):831-42.
2007: Stine F Pedersen; Barbara Vasek Darborg; Maria Rasmussen; Jesper Nylandsted; Else Hoffmann
The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):735-50.
2007: Stine F Pedersen; Bernd Nilius
Transient receptor potential channels in mechanosensing and cell volume regulation.
Methods in enzymology 2007;428():183-207.
2006: Stine F Pedersen; Kristian A Poulsen; Ian H Lambert
Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts.
American journal of physiology. Cell physiology 2006;291(6):C1286-96.
2006: Thomas Kjaer Klausen; Charlotte Hougaard; Else Hoffmann; Stine F Pedersen
Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin.
American journal of physiology. Cell physiology 2006;291(4):C757-71.
2006: Stine F Pedersen; Martha E O'Donnell; Steven E Anderson; Peter M Cala
Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(1):R1-25.
2006: Stine F Pedersen
The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death.
Pflügers Archiv : European journal of physiology 2006;452(3):249-59.
2006: Ian H Lambert; Stine F Pedersen; Kristian A Poulsen
Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia.
Acta physiologica (Oxford, England) 2006;187(1-2):75-85.
2006: Else Hoffmann; Ian H Lambert; Stine F Pedersen
12th Acta Physiologica International Symposium "cell volume control in health and disease.".
Acta physiologica (Oxford, England) 2006;187(1-2):1-3.
2006: Ian H Lambert; Stine F Pedersen
Multiple PLA2 isoforms regulate taurine release in NIH3T3 mouse fibroblasts.
Advances in experimental medicine and biology 2006;583():99-108.
2006: Else Hoffmann; Stine F Pedersen
Sensors and signal transduction pathways in vertebrate cell volume regulation.
Contributions to nephrology 2006;152():54-104.
2006: Marie E V Holt; Scott A King; Peter M Cala; Stine F Pedersen
Regulation of the Pleuronectes americanus Na+/H+ exchanger by osmotic shrinkage, beta-adrenergic stimuli, and inhibition of Ser/Thr protein phosphatases.
Cell biochemistry and biophysics 2006;45(1):1-18.
2005: Stine F Pedersen; Grzegorz Owsianik; Bernd Nilius
TRP channels: an overview.
Cell calcium 2005;38(3-4):233-52.
2004: Jesper W Voss; Stine F Pedersen; Søren T Christensen; Ian H Lambert
Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts.
European journal of biochemistry / FEBS 2004;271(23-24):4646-58.
2004: Jesper Nylandsted; Marja Jäättelä; Else Hoffmann; Stine F Pedersen
Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.
Pflügers Archiv : European journal of physiology 2004;449(2):175-85.
2004: Stine F Pedersen; Peter M Cala
Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes.
Journal of experimental zoology. Part A, Comparative experimental biology 2004;301(7):569-78.
2004: Else Hoffmann; Stine F Pedersen
Effectors and signaling events activated by cell shrinkage in ehrlich ascites tumor cells: implications for cell proliferation and programmed cell death.
Advances in experimental medicine and biology 2004;559():169-78.
2004: Stine F Pedersen
A novel NHE1 from red blood cells of the winter flounder: regulation by multiple signaling pathways.
Advances in experimental medicine and biology 2004;559():89-98.
2003: Nanna K Jorgensen; Stine F Pedersen; Hanne B Rasmussen; Morten Grunnet; Dan A Klaerke; Søren-Peter Olesen
Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.
Biochimica et biophysica acta 2003;1615(1-2):115-25.
2003: Stine F Pedersen; Scott A King; Robert R Rigor; Zhenpeng Zhuang; Jaimie M Warren; Peter M Cala
Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A.
American journal of physiology. Cell physiology 2003;284(6):C1561-76.
2002: Stine F Pedersen; Else Hoffmann
Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells.
Experimental cell research 2002;277(1):57-73.
2002: Stine F Pedersen; Kristine H Beisner; Charlotte Hougaard; Berthe M Willumsen; Ian H Lambert; Else Hoffmann
Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.
The Journal of physiology 2002;541(Pt 3):779-96.
2002: Maria Giulia Lionetto; Stine F Pedersen; Else Hoffmann; Maria E Giordano; Trifone Schettino
Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2002;12(4):163-78.
2001: Stine F Pedersen; Else Hoffmann; JW Mills
The cytoskeleton and cell volume regulation.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;130(3):385-99.
1999: Stine F Pedersen; JW Mills; Else Hoffmann
Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich ascites tumor cells.
Experimental cell research 1999;252(1):63-74.
1999: S Pedersen; Stine F Pedersen; Bernd Nilius; Ian H Lambert; Else Hoffmann
Mechanical stress induces release of ATP from Ehrlich ascites tumor cells.
Biochimica et biophysica acta 1999;1416(1-2):271-84.
1998: Stine F Pedersen; S Pedersen; Ian H Lambert; Else Hoffmann
P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells.
Biochimica et biophysica acta 1998;1374(1-2):94-106.
1998: Stine F Pedersen; N K Jørgensen; Else Hoffmann
Dynamics of Ca2+i and pHi in Ehrlich ascites tumor cells after Ca2+-mobilizing agonists or exposure to hypertonic solution.
Pflügers Archiv : European journal of physiology 1998;436(2):199-210.
1998: Stine F Pedersen; J Prenen; G Droogmans; Else Hoffmann; Bernd Nilius
Separate swelling- and Ca2+-activated anion currents in Ehrlich ascites tumor cells.
The Journal of membrane biology 1998;163(2):97-110.
1998: S Basavappa; Stine F Pedersen; N K Jørgensen; J Clive Ellory; Else Hoffmann
Swelling-induced arachidonic acid release via the 85-kDa cPLA2 in human neuroblastoma cells.
Journal of neurophysiology 1998;79(3):1441-9.
1998: Stine F Pedersen; N K Jørgensen; I Damgaard; A Schousboe; Else Hoffmann
Mechanisms of pHi regulation studied in individual neurons cultured from mouse cerebral cortex.
Journal of neuroscience research 1998;51(4):431-41.
1998: Else Hoffmann; Stine F Pedersen
Sensors and signal transduction in the activation of cell volume regulatory ion transport systems.
Contributions to nephrology 1998;123():50-78.
1998: Thomas Litman; Stine F Pedersen; B Kramhøft; Torben Skovsgaard; Else Hoffmann
pH regulation in sensitive and multidrug resistant Ehrlich ascites tumor cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1998;8(3):138-50.
1996: Stine F Pedersen; B Kramhøft; N K Jørgensen; Else Hoffmann
Shrinkage-induced activation of the Na+/H+ exchanger in Ehrlich ascites tumor cells: mechanisms involved in the activation and a role for the exchanger in cell volume regulation.
The Journal of membrane biology 1996;149(2):141-59.