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José Luis Pedraz

Research Profile

Chemicals & Drugs

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M Pastor; Arturo Talavera; Gemma Año; A Callicó; Bárbara Cedré; A Esquisabel; S Fernández; Juan F Infante; José Luis Pedraz
An approach to a cold chain free oral cholera vaccine: in vitro and in vivo characterization of Vibrio cholerae gastro-resistant microparticles.
Remedios Guadalupe Gomez-Mauricio; Rosa María Hernández; Argia Acarregui; Veronica Crisostomo; Ignacio Gallo; Gorka Orive; José Luis Pedraz; Francisco M Sánchez-Margallo; María F Martín-Cancho
A preliminary approach to the repair of myocardial infarction using adipose tissue-derived stem cells encapsulated in magnetic resonance-labelled alginate microspheres in a porcine model.
Gustavo Puras; J Zarate; Marcelino Avilés-Trigueros; A Díaz-Tahoces; E Fernández; José Luis Pedraz
Oligochitosan polyplexes as carriers for retinal gene delivery.

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All Publications

2013: M Pastor; Arturo Talavera; Gemma Año; A Callicó; Bárbara Cedré; A Esquisabel; S Fernández; Juan F Infante; José Luis Pedraz
An approach to a cold chain free oral cholera vaccine: in vitro and in vivo characterization of Vibrio cholerae gastro-resistant microparticles.
International journal of pharmaceutics 2013;448(1):247-58.
2013: Remedios Guadalupe Gomez-Mauricio; Rosa María Hernández; Argia Acarregui; Veronica Crisostomo; Ignacio Gallo; Gorka Orive; José Luis Pedraz; Francisco M Sánchez-Margallo; María F Martín-Cancho
A preliminary approach to the repair of myocardial infarction using adipose tissue-derived stem cells encapsulated in magnetic resonance-labelled alginate microspheres in a porcine model.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2013;84(1):29-39.
2013: Gustavo Puras; J Zarate; Marcelino Avilés-Trigueros; A Díaz-Tahoces; E Fernández; José Luis Pedraz
Oligochitosan polyplexes as carriers for retinal gene delivery.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2013;48(1-2):323-31.
2013: Edorta Santos; Alfonso Calvo; Leyre Larzabal; Gorka Orive; José Luis Pedraz; Rosa M Hernández
Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene.
Biomaterials 2013;34(4):1442-51.
2012: Aiala Salvador; José Luis Pedraz; Rosa M Hernández; Manuela Igartua
Plasmodium falciparum malaria vaccines: current status, pitfalls and future directions.
Expert review of vaccines 2012;11(9):1071-86.
2012: Ane Garate; Rosa M Hernández; Ainhoa Murua; Gorka Orive; José Luis Pedraz
Stem cells in alginate bioscaffolds.
Therapeutic delivery 2012;3(6):761-74.
2012: Edorta Santos; José Luis Pedraz; Rosa M Hernández; Gorka Orive
Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D.
Trends in biotechnology 2012;30(6):331-41.
2012: E Santos; A Calvo; R Catena; P Fernández-Robredo; Rosa M Hernández; A García Layana; Gorka Orive; José Luis Pedraz
Optimization of 100 μm alginate-poly-L-lysine-alginate capsules for intravitreous administration.
Journal of controlled release : official journal of the Controlled Release Society 2012;158(3):443-50.
2012: Desiree Antequera; Marta Bolos; Rosa M Rm A Hernández; Gorka Orive; José Luis Pedraz; Aitziber Portero; Eva Carro
Encapsulated VEGF-secreting cells enhance proliferation of neuronal progenitors in the hippocampus of AβPP/Ps1 mice.
Journal of Alzheimer's disease : JAD 2012;29(1):187-200.
2011: Gustavo Puras; A Salvador; Rosa M Hernández; Manuela Igartua; José Luis Pedraz
Encapsulation of Aβ(1-15) in PLGA microparticles enhances serum antibody response in mice immunized by subcutaneous and intranasal routes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;44(3):200-6.
2011: Elena Mata; Manuel E Patarroyo; José Luis Pedraz; Manuela Igartua; Rosa M Hernández
Enhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;44(1-2):32-40.
2011: Gemma Año; Yisabel Aranguren; Bárbara Cedré; Amaia Esquisabel; Gustavo Falero; Sonsire Fernández; Luis García; Marta Pastor; Sergio Sifontes; Rosa L Solís; Arturo Talavera; José Luis Pedraz
A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholerae.
Vaccine 2011;29(34):5758-64.
2011: Ainhoa Murua; Enara Herran; Gorka Orive; Manuela Igartua; Francisco Javier Blanco; José Luis Pedraz; Rosa M Hernández
Design of a composite drug delivery system to prolong functionality of cell-based scaffolds.
International journal of pharmaceutics 2011;407(1-2):142-50.
2011: Arantxazu Isla; Iñaki F Trocóniz; Andrés Canut; Alicia Labora; José Emilio Martín-Herrero; José Luis Pedraz; Alicia R Gascón
Pharmacokinetic/pharmacodynamic evaluation of amoxicillin, amoxicillin/clavulanate and ceftriaxone in the treatment of paediatric acute otitis media in Spain.
Enfermedades infecciosas y microbiología clínica 2011;29(3):167-73.
2011: Ainhoa Murua; Gorka Orive; Rosa M Hernández; José Luis Pedraz
Emerging technologies in the delivery of erythropoietin for therapeutics.
Medicinal research reviews 2011;31(2):284-309.
2011: L Ochoa; Manuela Igartua; Rosa M Hernández; Alicia R Gascón; M A Solinis; José Luis Pedraz
Novel extended-release formulation of lovastatin by one-step melt granulation: in vitro and in vivo evaluation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;77(2):306-12.
2011: Aiala Salvador; Rosa M Hernández; Manuela Igartua; José Luis Pedraz
An overview on the field of micro- and nanotechnologies for synthetic Peptide-based vaccines.
Journal of drug delivery 2011;2011():181646.
2010: Gorka Orive; Rosa M Hernández; Ainhoa Murua; José Luis Pedraz
Recent advances in the use of encapsulated cells for effective delivery of therapeutics.
Therapeutic delivery 2010;1(3):387-96.
2010: Raúl Catena; Edorta Santos; Gorka Orive; Rosa María Hernández; José Luis Pedraz; Alfonso Calvo
Improvement of the monitoring and biosafety of encapsulated cells using the SFGNESTGL triple reporter system.
Journal of controlled release : official journal of the Controlled Release Society 2010;146(1):93-8.
2010: Rosa M Hernández; Gorka Orive; Ainhoa Murua; José Luis Pedraz
Microcapsules and microcarriers for in situ cell delivery.
Advanced drug delivery reviews 2010;62(7-8):711-30.
2010: Lourdes Ochoa; Manuela Igartua; Rosa M Hernández; María Angeles Solinís; Alicia R Gascón; José Luis Pedraz
In vivo evaluation of two new sustained release formulations elaborated by one-step melt granulation: level A in vitro-in vivo correlation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2010;75(2):232-7.
2010: Ainhoa Murua; Gorka Orive; Rosa M Hernandez; José Luis Pedraz
Epo delivery by genetically engineered C2C12 myoblasts immobilized in microcapsules.
Advances in experimental medicine and biology 2010;670():54-67.
2010: Edorta Santos; Jon Zarate; Gorka Orive; Rosa M Hernández; José Luis Pedraz
Biomaterials in cell microencapsulation.
Advances in experimental medicine and biology 2010;670():5-21.
2010: Gorka Orive; José Luis Pedraz
Highlights and trends in cell encapsulation.
Advances in experimental medicine and biology 2010;670():1-4.
2009: María de Castro; Gorka Orive; Rosa M Hernández; Artur Bartkowiak; W Brylak; José Luis Pedraz
Biocompatibility and in vivo evaluation of oligochitosans as cationic modifiers of alginate/Ca microcapsules.
Journal of biomedical materials research. Part A 2009;91(4):1119-30.
2009: Gorka Orive; Eduardo Anitua; José Luis Pedraz; Dwaine F Emerich
Biomaterials for promoting brain protection, repair and regeneration.
Nature reviews. Neuroscience 2009;10(9):682-92.
2009: Ainhoa Murua; Gorka Orive; Rosa M Hernández; José Luis Pedraz
Xenogeneic transplantation of erythropoietin-secreting cells immobilized in microcapsules using transient immunosuppression.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(3):174-8.
2009: Ainhoa Murua; Gorka Orive; Rosa M Hernández; José Luis Pedraz
Cryopreservation based on freezing protocols for the long-term storage of microencapsulated myoblasts.
Biomaterials 2009;30(20):3495-501.
2009: Dorleta Otaegui; Alicia Rodríguez Gascón; Aizpea Zubia; Fernando P Cossío; José Luis Pedraz
Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice.
Cancer chemotherapy and pharmacology 2009;64(1):153-9.
2009: Gorka Orive; María de Castro; Hyun-Joon Kong; Rosa M Hernández; Sara Ponce; David J Mooney; José Luis Pedraz
Bioactive cell-hydrogel microcapsules for cell-based drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2009;135(3):203-10.
2009: Paul de Vos; Marek Bucko; Peter Gemeiner; Marián Navrátil; Juraj Svitel; Marijke M Faas; Berit Løkensgard Strand; Gudmund Skjak-Braek; Yrr A Morch; Alica Vikartovská; Igor Lacík; Gabriela Kolláriková; Gorka Orive; Dennis Poncelet; José Luis Pedraz; Marion B Ansorge-Schumacher
Multiscale requirements for bioencapsulation in medicine and biotechnology.
Biomaterials 2009;30(13):2559-70.
2009: A del Pozo-Rodríguez; María Angeles Solinís; Alicia R Gascón; José Luis Pedraz
Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;71(2):181-9.
2009: A del Pozo-Rodríguez; S Pujals; D Delgado; María Angeles Solinís; Alicia R Gascón; E Giralt; José Luis Pedraz
A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors.
Journal of controlled release : official journal of the Controlled Release Society 2009;133(1):52-9.
2008: Ainhoa Murua; Aitziber Portero; Gorka Orive; Rosa M Hernández; María de Castro; José Luis Pedraz
Cell microencapsulation technology: towards clinical application.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(2):76-83.
2008: A del Pozo-Rodríguez; D Delgado; María Angeles Solinís; Alicia R Gascón; José Luis Pedraz
Solid lipid nanoparticles for retinal gene therapy: transfection and intracellular trafficking in RPE cells.
International journal of pharmaceutics 2008;360(1-2):177-83.
2008: Dorleta Otaegui; Alicia Rodríguez Gascón; Aizpea Zubia; Fernando P Cossío; José Luis Pedraz
Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of Kendine 91, a novel histone deacetylase inhibitor, in mice plasma and tissues: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;870(1):109-16.
2008: Arantxazu Isla; Alicia Rodríguez Gascón; Iñaki F Trocóniz; Lorea Bueno; María Angeles Solinís; Javier Maynar; José Angel Sánchez-Izquierdo; José Luis Pedraz
Population pharmacokinetics of meropenem in critically ill patients undergoing continuous renal replacement therapy.
Clinical pharmacokinetics 2008;47(3):173-80.
2007: Ainhoa Murua; María de Castro; Gorka Orive; Rosa Maria Hernandez; José Luis Pedraz
In vitro characterization and in vivo functionality of erythropoietin-secreting cells immobilized in alginate-poly-L-lysine-alginate microcapsules.
Biomacromolecules 2007;8(11):3302-7.
2007: Laura Grandoso; Sara Ponce; Ivan Manuel; Aurora Arrúe; José Angel Ruiz-Ortega; Isabel Ulibarri; Gorka Orive; Rosa M Hernández; Alicia Rodríguez; Rafael Rodriguez-Puertas; Mercedes Zumárraga; Gurutz Linazasoro; José Luis Pedraz; Luisa Ugedo
Long-term survival of encapsulated GDNF secreting cells implanted within the striatum of parkinsonized rats.
International journal of pharmaceutics 2007;343(1-2):69-78.
2007: A del Pozo-Rodríguez; D Delgado; María Angeles Solinís; Alicia R Gascón; José Luis Pedraz
Solid lipid nanoparticles: formulation factors affecting cell transfection capacity.
International journal of pharmaceutics 2007;339(1-2):261-8.
2007: E Mata; Angel M Carcaboso; Rosa M Hernández; Manuela Igartua; G Corradin; José Luis Pedraz
Adjuvant activity of polymer microparticles and Montanide ISA 720 on immune responses to Plasmodium falciparum MSP2 long synthetic peptides in mice.
Vaccine 2007;25(5):877-85.
2007: Arantxazu Isla; Alicia R Gascón; Javier Maynar; Alazne Arzuaga; José Angel Sánchez-Izquierdo; José Luis Pedraz
In vitro AN69 and polysulphone membrane permeability to ceftazidime and in vivo pharmacokinetics during continuous renal replacement therapies.
Chemotherapy 2007;53(3):194-201.
2006: Sara Ponce; Gorka Orive; Rosa M Hernández; Alicia R Gascón; J M Canals; M T Muñoz; José Luis Pedraz
In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(1):28-34.
2006: Sara Ponce; Gorka Orive; Rosa Hernández; Alicia R Gascón; José Luis Pedraz; Bart J De Haan; Marijke M Faas; H J Mathieu; Paul de Vos
Chemistry and the biological response against immunoisolating alginate-polycation capsules of different composition.
Biomaterials 2006;27(28):4831-9.
2006: Eddy Castellanos Gil; Antonio Iraizoz Colarte; Bernard Bataille; José Luis Pedraz; Fernand Rodríguez; Jyrki Heinämäki
Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride.
International journal of pharmaceutics 2006;317(1):32-9.
2006: Gorka Orive; Susan K Tam; José Luis Pedraz; Jean-Pierre Hallé
Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy.
Biomaterials 2006;27(20):3691-700.
2006: María de Castro; Gorka Orive; Alicia R Gascón; Rosa Maria Hernandez; José Luis Pedraz
Evaluation of human serum albumin as a substitute of foetal bovine serum for cell culture.
International journal of pharmaceutics 2006;310(1-2):8-14.
2006: Alazne Arzuaga; Arantxazu Isla; Alicia R Gascón; Javier Maynar; Esther Corral; José Luis Pedraz
Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters: evaluation of the sieving coefficient.
Blood purification 2006;24(4):347-54.
2005: I Beobide; Andrés Canut; Alicia R Gascón; Arantxazu Isla; C García-Rey; I De La Maza; Alicia Labora; José Luis Pedraz
Evaluation of antimicrobial treatments in children with acute otitis media in Spain: a pharmacokinetic-pharmacodynamic (PK/PD) approach.
Journal of chemotherapy (Florence, Italy) 2005;17(6):628-35.
2005: Arantxazu Isla; Javier Maynar; José Angel Sánchez-Izquierdo; Alicia R Gascón; Alazne Arzuaga; Esther Corral; José Luis Pedraz
Meropenem and continuous renal replacement therapy: in vitro permeability of 2 continuous renal replacement therapy membranes and influence of patient renal function on the pharmacokinetics in critically ill patients.
Journal of clinical pharmacology 2005;45(11):1294-304.
2005: Arantxazu Isla; Alazne Arzuaga; Javier Maynar; Alicia R Gascón; María Angeles Solinís; Esther Corral; José Luis Pedraz
Determination of ceftazidime and cefepime in plasma and dialysate-ultrafiltrate from patients undergoing continuous veno-venous hemodiafiltration by HPLC.
Journal of pharmaceutical and biomedical analysis 2005;39(5):996-1005.
2005: Alazne Arzuaga; Arantxazu Isla; Alicia R Gascón; Javier Maynar; A Martín; María Angeles Solinís; D Toral; José Luis Pedraz
Quantitation and stability of piperacillin and tazobactam in plasma and ultrafiltrate from patients undergoing continuous venovenous hemofiltration by HPLC.
Biomedical chromatography : BMC 2005;19(8):570-8.
2005: Gorka Orive; María de Castro; Sara Ponce; Rosa M Hernández; Alicia R Gascón; Miquel Bosch; J Alberch; José Luis Pedraz
Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(2):283-9.
2005: Gorka Orive; A Bartkowiak; S Lisiecki; María de Castro; Rosa M Hernández; A R Gascòn; José Luis Pedraz
Biocompatible oligochitosans as cationic modifiers of alginate/Ca microcapsules.
Journal of biomedical materials research. Part B, Applied biomaterials 2005;74(1):429-39.
2005: Arantxazu Isla; Andrés Canut; Alicia Rodríguez Gascón; José Luis Pedraz
[Pharmacokinetics/pharmacodynamics of the 1000/62.5 formulation of amoxicillin/clavulanic acid in odontostomatology].
Enfermedades infecciosas y microbiología clínica 2005;23(6):387.
2005: María de Castro; Gorka Orive; Rosa M Hernández; Alicia R Gascón; José Luis Pedraz
Comparative study of microcapsules elaborated with three polycations (PLL, PDL, PLO) for cell immobilization.
Journal of microencapsulation 2005;22(3):303-15.
2005: Arantxazu Isla; Alicia R Gascón; Javier Maynar; Alazne Arzuaga; Darío Toral; José Luis Pedraz
Cefepime and continuous renal replacement therapy (CRRT): in vitro permeability of two CRRT membranes and pharmacokinetics in four critically ill patients.
Clinical therapeutics 2005;27(5):599-608.
2005: Sara Ponce; Gorka Orive; Alicia R Gascón; Rosa M Hernández; José Luis Pedraz
Microcapsules prepared with different biomaterials to immobilize GDNF secreting 3T3 fibroblasts.
International journal of pharmaceutics 2005;293(1-2):1-10.
2005: Gorka Orive; Angel M Carcaboso; Rosa M Hernández; Alicia R Gascón; José Luis Pedraz
Biocompatibility evaluation of different alginates and alginate-based microcapsules.
Biomacromolecules 2005;6(2):927-31.
2005: Arantxazu Isla; Andrés Canut; Alicia Rodríguez Gascón; Alicia Labora; Bruno Ardanza-Trevijano; María Angeles Solinís; José Luis Pedraz
[Pharmacokinetic/pharmacodynamic analysis of antibiotic therapy in dentistry and stomatology].
Enfermedades infecciosas y microbiología clínica 2005;23(3):116-21.
2005: Alazne Arzuaga; Javier Maynar; Alicia R Gascón; Arantxazu Isla; Esther Corral; Fernando Fonseca; José Angel Sánchez-Izquierdo; jordi rello; Andrés Canut; José Luis Pedraz
Influence of renal function on the pharmacokinetics of piperacillin/tazobactam in intensive care unit patients during continuous venovenous hemofiltration.
Journal of clinical pharmacology 2005;45(2):168-76.
2005: Lourdes Ochoa; Manuela Igartua; Rosa M Hernández; Alicia R Gascón; José Luis Pedraz
Preparation of sustained release hydrophilic matrices by melt granulation in a high-shear mixer.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2005;8(2):132-40.
2005: L Arús; Gorka Orive; R Hernández; A Rodriguez; Armando Rojas; José Luis Pedraz
The influence of cellular seeding density in the microencapsulation of hybridoma cells.
Journal of biomaterials science. Polymer edition 2005;16(4):521-9.
2005: Arantxazu Isla; Andrés Canut; Alicia R Gascón; Alicia Labora; Bruno Ardanza-Trevijano; María Angeles Solinís; José Luis Pedraz
Pharmacokinetic/pharmacodynamic evaluation of antimicrobial treatments of orofacial odontogenic infections.
Clinical pharmacokinetics 2005;44(3):305-16.
2004: Gorka Orive; Alicia R Gascón; Rosa M Hernández; José Luis Pedraz
The search for new beta-cell sources.
Trends in biotechnology 2004;22(12):612-3.
2004: Gorka Orive; Alicia R Gascón; Rosa M Hernández; Alfonso Domínguez-Gil; José Luis Pedraz
Techniques: new approaches to the delivery of biopharmaceuticals.
Trends in pharmacological sciences 2004;25(7):382-7.
2004: Antonio Cuadrado; Alicia R Gascón; María Angeles Solinís; E Ramírez; Rosa M Hernández; Ulrich Knie; José Luis Pedraz
Bioequivalence of two oral ciprofloxacin tablets formulations.
International journal of clinical pharmacology and therapeutics 2004;42(6):336-41.
2004: Angel M Carcaboso; Rosa M Hernández; Manuela Igartua; Jaiver Rosas; Manuel E Patarroyo; José Luis Pedraz
Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles.
Vaccine 2004;22(11-12):1423-32.
2004: Gorka Orive; Rosa M Hernández; Alicia Rodríguez Gascón; Riccardo Calafiore; Thomas Ming Swi Chang; Paul de Vos; Gonzalo Hortelano; David Hunkeler; Igor Lacík; José Luis Pedraz
History, challenges and perspectives of cell microencapsulation.
Trends in biotechnology 2004;22(2):87-92.
2004: Angel M Carcaboso; Rosa M Hernández; Manuela Igartua; Jaiver Rosas; Manuel E Patarroyo; José Luis Pedraz
Enhancing immunogenicity and reducing dose of microparticulated synthetic vaccines: single intradermal administration.
Pharmaceutical research 2004;21(1):121-6.
2003: Gorka Orive; Rosa M Hernández; Alicia Rodríguez Gascón; Alfonso Domínguez-Gil; José Luis Pedraz
Drug delivery in biotechnology: present and future.
Current opinion in biotechnology 2003;14(6):659-64.
2003: Gorka Orive; Stephan J Reshkin; Salvador Harguindey; José Luis Pedraz
Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis.
British journal of cancer 2003;89(8):1395-9.
2003: Angel M Carcaboso; Rosa M Hernández; Manuela Igartua; Alicia R Gascón; Jaiver Rosas; Manuel E Patarroyo; José Luis Pedraz
Immune response after oral administration of the encapsulated malaria synthetic peptide SPf66.
International journal of pharmaceutics 2003;260(2):273-82.
2003: Alicia R Gascón; Antonio Cuadrado; María Angeles Solinís; Rosa M Hernández; E Ramírez; R Dalmau; José Luis Pedraz
Comparative bioavailability of two immediate-release tablets of lisinopril/hydrochlorothiazide in healthy volunteers.
International journal of clinical pharmacology and therapeutics 2003;41(7):309-15.
2003: I Gutierro; Rosa M Hernández; Manuela Igartua; Alicia R Gascón; José Luis Pedraz
Immune responses to orally administered PLGA microparticles: influence of oil vehicles and surfactive agents.
Journal of microencapsulation 2003;20(4):525-36.
2003: Gorka Orive Arroyo; Rosa M Hernánedez; Alicia R Gascón; Manuela Igartua; José Luis Pedraz
A glimmer of hope for diabetics?
Trends in biotechnology 2003;21(7):289-90.
2003: Gorka Orive; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; José Luis Pedraz
Development and optimisation of alginate-PMCG-alginate microcapsules for cell immobilisation.
International journal of pharmaceutics 2003;259(1-2):57-68.
2003: Alicia R Gascón; G Gutiérrez-Aragón; Rosa M Hernández; J Errasti; José Luis Pedraz
Pharmacokinetics and tissue penetration of pefloxacin plus metronidazole after administration as surgical prophylaxis in colorectal surgery.
International journal of clinical pharmacology and therapeutics 2003;41(6):267-74.
2003: Gorka Orive; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; José Luis Pedraz
Controversies over stem cell research.
Trends in biotechnology 2003;21(3):109-12.
2003: Antonio Cuadrado; Alicia Rodríguez Gascón; Rosa M Hernández; Ana María Castilla; Ane de la Maza; Carlos Yánez; Alicia López de Ocáriz; María Angeles Solinís; José Luis Pedraz
In vivo pharmacokinetic-pharmacodynamic relationship and in vitro equivalence of two oral furosemide tablet formulations.
Arzneimittel-Forschung 2003;53(5):321-9.
2003: Gorka Orive; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; José Luis Pedraz
Survival of different cell lines in alginate-agarose microcapsules.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;18(1):23-30.
2003: Gorka Orive; Rosa M Hernández; Alicia R Gascón; Riccardo Calafiore; Thomas Ming Swi Chang; Paul de Vos; Gonzalo Hortelano; David Hunkeler; Igor Lacík; A M James Shapiro; José Luis Pedraz
Cell encapsulation: promise and progress.
Nature medicine 2003;9(1):104-7.
2002: I Gutierro; Rosa M Hernández; Manuela Igartua; Alicia R Gascón; José Luis Pedraz
Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres.
Vaccine 2002;21(1-2):67-77.
2002: María Angeles Solinís; Yaimy de la Cruz; Begoña Calvo; Rosa M Hernández; Alicia R Gascón; Isabel Goñi; Mariló Gurruchaga; José Luis Pedraz
Release of salbutamol sulphate and ketoprofen enantiomers from matrices containing HPMC and cellulose derivatives.
Chirality 2002;14(10):806-13.
2002: Alicia R Gascón; E Campo; E Olea; Rosa M Hernández; Begoña Calvo; J Errasti; José Luis Pedraz
Pharmacokinetics and tissue distribution of intravenous pefloxacin for antibiotic prophylaxis in biliary surgery.
Biopharmaceutics & drug disposition 2002;23(7):293-300.
2002: Gorka Orive; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; José Luis Pedraz
Encapsulated cell technology: from research to market.
Trends in biotechnology 2002;20(9):382-7.
2002: Gorka Orive; Sara Ponce; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; José Luis Pedraz
Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates.
Biomaterials 2002;23(18):3825-31.
2002: María Angeles Solinís; Y de la Cruz; Rosa M Hernández; Alicia R Gascón; Begoña Calvo; José Luis Pedraz
Release of ketoprofen enantiomers from HPMC K100M matrices--diffusion studies.
International journal of pharmaceutics 2002;239(1-2):61-8.
2002: I Gutierro; Rosa M Hernández; Manuela Igartua; Alicia R Gascón; José Luis Pedraz
Influence of dose and immunization route on the serum Ig G antibody response to BSA loaded PLGA microspheres.
Vaccine 2002;20(17-18):2181-90.
2002: Jaiver Rosas; José Luis Pedraz; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; Fanny Guzmán; R Rodríguez; Jimena Cortés; Manuel E Patarroyo
Remarkably high antibody levels and protection against P. falciparum malaria in Aotus monkeys after a single immunisation of SPf66 encapsulated in PLGA microspheres.
Vaccine 2002;20(13-14):1707-10.
2002: A Esquisabel; Rosa Maria Hernandez; Manuela Igartua; Alicia R Gascón; Begoña Calvo; José Luis Pedraz
Preparation and stability of agarose microcapsules containing BCG.
Journal of microencapsulation 2002;19(2):237-44.
2002: Manuela Igartua; Patrick Saulnier; Béatrice Heurtault; Brigitte Pech; Jacques-Emile Proust; José Luis Pedraz; Jean-Pierre Benoit
Development and characterization of solid lipid nanoparticles loaded with magnetite.
International journal of pharmaceutics 2002;233(1-2):149-57.
2002: Antonio Cuadrado; Alicia Rodríguez Gascón; Rosa M Hernández; Ana María Castilla; Ane de la Maza; Alicia López de Ocáriz; Begoña Calvo; José Luis Pedraz
In vitro and in vivo equivalence of two oral atenolol tablet formulations.
Arzneimittel-Forschung 2002;52(5):371-8.
2001: Gorka Orive; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; Armando Rojas; José Luis Pedraz
Microencapsulation of an anti-VE-cadherin antibody secreting 1B5 hybridoma cells.
Biotechnology and bioengineering 2001;76(4):285-94.
2001: Manuela Igartua; Rosa M Hernández; I Gutierro; Alicia R Gascón; José Luis Pedraz
Preliminary assessment of the immune response to Olea europaea pollen extracts encapsulated into PLGA microspheres.
Pharmaceutical development and technology 2001;6(4):621-7.
2001: Jaiver Rosas; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; F Guzman; Manuel E Patarroyo; José Luis Pedraz
Biodegradable PLGA microspheres as a delivery system for malaria synthetic peptide SPf66.
Vaccine 2001;19(31):4445-51.
2001: A M Maza; AR Gascon; Rosa Maria Hernandez; M A Solinis; MB Calvo; José Luis Pedraz
Influence of hepatic regeneration after partial hepatectomy on theophylline pharmacokinetics in rats.
European journal of drug metabolism and pharmacokinetics 2001;26(1-2):53-8.
2000: A San Vicente; Rosa M Hernández; Alicia R Gascón; MB Calvo; José Luis Pedraz
Effect of aging on the release of salbutamol sulfate from lipid matrices.
International journal of pharmaceutics 2000;208(1-2):13-21.
2000: A Esquisabel; Rosa M Hernández; Manuela Igartua; Alicia R Gascón; Begoña Calvo; José Luis Pedraz
Effect of lecithins on BCG-alginate-PLL microcapsule particle size and stability upon storage.
Journal of microencapsulation 2000;17(3):363-72.
2000: Salvador Harguindey; José Luis Pedraz; R G Cañero; M Katin
Edelfosine, apoptosis, MDR and Na+/H+ exchanger: induction mechanisms and treatment implications.
Apoptosis : an international journal on programmed cell death 2000;5(1):87-9.
1998: Manuela Igartua; Rosa M Hernández; A Esquisabel; Alicia R Gascón; MB Calvo; José Luis Pedraz
Enhanced immune response after subcutaneous and oral immunization with biodegradable PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):63-73.
1998: R M Hernádez; Manuela Igartua; Alicia R Gascón; MB Calvo; José Luis Pedraz
Influence of shaking and surfactants on the release of bsa from plga microspheres.
European journal of drug metabolism and pharmacokinetics 1998;23(2):92-6.
1998: Alicia R Gascón; E Campo; Rosa M Hernández; Begoña Calvo; J Errasti; José Luis Pedraz
Pharmacokinetics and tissue distribution of intravenous ofloxacin for antibiotic prophylaxis in biliary surgery.
Clinical drug investigation 1998;15(6):491-6.
1997: A Esquisabel; Rosa M Hernández; Alicia R Gascón; Manuela Igartua; Begoña Calvo; José Luis Pedraz
Determination of salbutamol enantiomers by high-performance capillary electrophoresis and its application to dissolution assays.
Journal of pharmaceutical and biomedical analysis 1997;16(2):357-66.
1997: A Esquisabel; Rosa M Hernández; Manuela Igartua; Alicia R Gascón; Begoña Calvo; José Luis Pedraz
Production of BCG alginate-PLL microcapsules by emulsification/internal gelation.
Journal of microencapsulation 1997;14(5):627-38.
1997: Manuela Igartua; Rosa M Hernández; A Esquisabel; AR Gascon; MB Calvo; José Luis Pedraz
Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems.
Journal of microencapsulation 1997;14(3):349-56.
1997: Rosa M Hernández; Alicia R Gascón; MB Calvo; C Caramella; U Conte; Alfonso Domínguez-Gil; José Luis Pedraz
Influence of route of administration and dosage form in the pharmacokinetics and bioavailability of salbutamol.
European journal of drug metabolism and pharmacokinetics 1997;22(2):145-50.
1997: A M Maza; AR Gascon; MB Calvo; Rosa Maria Hernandez; M A Monte; J J Marin; A Dominguez-Gil; José Luis Pedraz
Influence of partial hepatectomy in rats on the activity of hepatic microsomal enzymatic systems.
European journal of drug metabolism and pharmacokinetics 1997;22(1):15-23.
1996: A Maza; Alicia R Gascón; MB Calvo; Rosa M Hernández; José Luis Pedraz
Influence of partial hepatectomy on theophylline pharmacokinetics in rats.
Journal of pharmaceutical sciences 1996;85(10):1133-5.
1995: Begoña Calvo; José Luis Pedraz; Alicia R Gascón; Rosa M Hernández; E García-Ortega; F Vara; C Muriel; Alfonso Domínguez-Gil
The influence of adrenalin on the pharmacokinetics of interpleurally administered lidocaine in patients with pancreatic neoplasia.
Journal of clinical pharmacology 1995;35(4):426-31.
1994: Alicia R Gascón; Begoña Calvo; Rosa M Hernández; Alfonso Domínguez-Gil; José Luis Pedraz
Interspecies scaling of cimetidine-theophylline pharmacokinetic interaction: interspecies scaling in pharmacokinetic interactions.
Pharmaceutical research 1994;11(7):945-50.
1992: José Luis Pedraz; Begoña Calvo; J A Smithers; G A Thompson
Pharmacokinetic-pharmacodynamic modeling: time-dependent protein binding--an alternative interpretation of clockwise and counterclockwise hysteresis.
Journal of pharmaceutical sciences 1992;81(3):232-6.
1991: José Luis Pedraz; MB Calvo; A R Gascon; R Hernandez; C Muriel; L M Torres; Alfonso Dominguez-Gil
Pharmacokinetics and distribution of ketamine after extradural administration to dogs.
British journal of anaesthesia 1991;67(3):310-6.
1991: Begoña Calvo; José Luis Pedraz; Alicia R Gascón; Alfonso Domínguez-Gil
[Validity of preclinical research in the development of new antibiotics. Pharmacokinetic aspects].
Enfermedades infecciosas y microbiología clínica 1991;9(6):361-9.
1991: J M Sánchez-Torres; José Luis Pedraz; Alicia R Gascón; M Begoña Calvo; Rosa M Hernández; Alfonso Domínguez-Gil
Biotransformation kinetic of binifibrate and identification of its metabolites.
Bollettino chimico farmaceutico 1991;130(5):172-7.
1990: MB Calvo; José Luis Pedraz; Alfonso Domínguez-Gil
Pharmacokinetics of dibenzylamine administered in a sustained drug delivery system with cefazolin.
Biopharmaceutics & drug disposition 1990;11(9):797-806.
1989: José Luis Pedraz; MB Calvo; José M Lanao; C Muriel; J Santos Lamas; Alfonso Domínguez-Gil
Pharmacokinetics of rectal ketamine in children.
British journal of anaesthesia 1989;63(6):671-4.
1989: José Luis Pedraz; Begoña Calvo; Angela Bortolotti; A Celardo; M Bonati
Bioavailability of intramuscular vitamin E acetate in rabbits.
The Journal of pharmacy and pharmacology 1989;41(6):415-7.
1989: MB Calvo; José Luis Pedraz; Alfonso Domínguez-Gil
Determination of low concentrations of dibenzylamine in human plasma and urine by gas chromatography with a nitrogen-phosphorus detector.
Journal of chromatography 1989;490(1):206-12.
1988: José Luis Pedraz; MB Calvo; José M Lanao; Alfonso Dominguez-Gil
Choice of optimum pharmacokinetic model of orally administered paracetamol.
Biopharmaceutics & drug disposition 1988;9(4):389-96.
1988: José Luis Pedraz; E Alonso; MB Calvo; José M Lanao; Alfonso Dominguez-Gil
Bioequivalence study of two oral formulations of paracetamol.
International journal of clinical pharmacology, therapy, and toxicology 1988;26(5):232-6.
1987: José Luis Pedraz; José M Lanao; MB Calvo; C Muriel; J Hernández-Arbeiza; Alfonso Domínguez-Gil
Pharmacokinetic and clinical evaluation of ketamine administered by i.v. and epidural routes.
International journal of clinical pharmacology, therapy, and toxicology 1987;25(2):77-80.
1986: José Luis Pedraz; MB Calvo; José M Lanao; Alfonso Dominguez-Gil
Urinary and biliary excretion kinetics of ketamine and its metabolites in the rabbit.
Bollettino chimico farmaceutico 1986;125(9):357-61.
1986: MB Calvo; M J García; José Luis Pedraz; Alfonso Domínguez-Gil
Bioavailability of amoxapine in experimental animals.
Bollettino chimico farmaceutico 1986;125(8):307-11.
1986: José Luis Pedraz; José M Lanao; J M Hernandez; Alfonso Domínguez-Gil
The biotransformation kinetics of ketamine "in vitro" in rabbit liver and lung microsome fractions.
European journal of drug metabolism and pharmacokinetics 1986;11(1):9-16.
1985: MB Calvo; M J García; José Luis Pedraz; F Prieto Aguirre; A Ledesma; Alfonso Domínguez-Gil
[Relation of blood levels of amoxapine and its active metabolites to its pharmacologic response and toxicity].
Medicina clínica 1985;85(7):269-72.
1985: Begoña Calvo; M J García; José Luis Pedraz; Eduardo Mariño; Alfonso Domínguez-Gil
Pharmacokinetics of amoxapine and its active metabolites.
International journal of clinical pharmacology, therapy, and toxicology 1985;23(4):180-5.
1985: A Dominguez-Gil; José M Lanao; José Luis Pedraz
Clinical significance of serum levels of antibiotics.
International journal of clinical pharmacology, therapy, and toxicology 1985;23 Suppl 1():S62-7.
1985: José Luis Pedraz; José M Lanao; A Dominguez-Gil
Kinetics of ketamine and its metabolites in rabbits with normal and impaired renal function.
European journal of drug metabolism and pharmacokinetics 1985;10(1):33-9.
1984: José M Lanao; José Luis Pedraz; A S Navarro; A Dominguez-Gil
Influence of dose in the urinary excretion of amikacin.
International journal of clinical pharmacology, therapy, and toxicology 1984;22(10):538-42.
1983: José Luis Pedraz; Eduardo Mariño; A Dominguez-Gil
Quantitative determination of ketamine and its metabolites in man by gas-liquid chromatography.
Il Farmaco; edizione pratica 1983;38(5):209-18.