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Frank Peelman

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Celia Bovijn; Anne-Sophie Desmet; Jan Tavernier; Isabel Uyttendaele; Tim Van Acker; Frank Peelman
Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal).
Celia Bovijn; Dominiek Catteeuw; Anne-Sophie De Smet; Jan Tavernier; Peter Ulrichts; Rudi Beyaert; Frank Peelman
Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.
Isabel Uyttendaele; Jan Tavernier; Celia Bovijn; Dominiek Catteeuw; Delphine Lavens; Irma Lemmens; Frank Peelman
Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G.

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All Publications

2013: Celia Bovijn; Anne-Sophie Desmet; Jan Tavernier; Isabel Uyttendaele; Tim Van Acker; Frank Peelman
Identification of Binding Sites for Myeloid Differentiation Primary Response Gene 88 (MyD88) and Toll-like Receptor 4 in MyD88 Adapter-like (Mal).
The Journal of biological chemistry 2013;288(17):12054-66.
2012: Celia Bovijn; Dominiek Catteeuw; Anne-Sophie De Smet; Jan Tavernier; Peter Ulrichts; Rudi Beyaert; Frank Peelman
Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.
The Journal of biological chemistry 2012;287(6):4088-98.
2012: Isabel Uyttendaele; Jan Tavernier; Celia Bovijn; Dominiek Catteeuw; Delphine Lavens; Irma Lemmens; Frank Peelman
Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G.
PloS one 2012;7(9):e44143.
2008: Julie Piessevaux; Leentje De Ceuninck; Dominiek Catteeuw; Frank Peelman; Jan Tavernier
Elongin B/C recruitment regulates substrate binding by CIS.
The Journal of biological chemistry 2008;283(31):21334-46.
2007: Isabel Uyttendaele; Irma Lemmens; Annick Verhee; Anne-Sophie De Smet; Joël Vandekerckhove; Delphine Lavens; Frank Peelman; Jan Tavernier
Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2821-31.
2007: Peter Ulrichts; Frank Peelman; Rudi Beyaert; Jan Tavernier
MAPPIT analysis of TLR adaptor complexes.
FEBS letters 2007;581(4):629-36.
2007: Delphine Lavens; Peter Ulrichts; Dominiek Catteeuw; Kris Gevaert; Joël Vandekerckhove; Frank Peelman; Sven Eyckerman; Jan Tavernier
The C-terminus of CIS defines its interaction pattern.
The Biochemical journal 2007;401(1):257-67.
2006: Julie Piessevaux; Delphine Lavens; Tony Montoye; Joris Wauman; Dominiek Catteeuw; Joël Vandekerckhove; Denise Belsham; Frank Peelman; Jan Tavernier
Functional cross-modulation between SOCS proteins can stimulate cytokine signaling.
The Journal of biological chemistry 2006;281(44):32953-66.
2006: Frank Peelman; Hannes Iserentant; Anne-Sophie De Smet; Joël Vandekerckhove; Lennart Zabeau; Jan Tavernier
Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex.
The Journal of biological chemistry 2006;281(22):15496-504.
2006: Frank Peelman; Cyril Couturier; Julie Dam; Lennart Zabeau; Jan Tavernier; Ralf JOckers
Techniques: new pharmacological perspectives for the leptin receptor.
Trends in pharmacological sciences 2006;27(4):218-25.
2006: Debby Polet; Anja Lambrechts; K Ono; Allan K Mah; Frank Peelman; Joël Vandekerckhove; David Baillie; Christophe Ampe; S Ono
Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner.
Cell motility and the cytoskeleton 2006;63(1):14-28.
2005: Lennart Zabeau; Delphine Defeau; Hannes Iserentant; Joël Vandekerckhove; Frank Peelman; Jan Tavernier
Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains.
The Journal of biological chemistry 2005;280(24):22632-40.
2005: Hannes Iserentant; Frank Peelman; Delphine Defeau; Joël Vandekerckhove; Lennart Zabeau; Jan Tavernier
Mapping of the interface between leptin and the leptin receptor CRH2 domain.
Journal of cell science 2005;118(Pt 11):2519-27.
2005: Frank Peelman; Hannes Iserentant; Sven Eyckerman; Lennart Zabeau; Jan Tavernier
Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists.
Current pharmaceutical design 2005;11(4):539-48.
2004: Frank Peelman; Katrien van Beneden; Lennart Zabeau; Hannes Iserentant; Peter Ulrichts; Delphine Defeau; Annick Verhee; Dominiek Catteeuw; Dirk Elewaut; Jan Tavernier
Mapping of the leptin binding sites and design of a leptin antagonist.
The Journal of biological chemistry 2004;279(39):41038-46.
2004: Stein Roosbeek; Frank Peelman; Annick Verhee; Christine Labeur; Hans Caster; Marc F Lensink; Claudia Cirulli; Johan Grooten; Claude Cochet; Joël Vandekerckhove; Angela Amoresano; Giovanna Chimini; Jan Tavernier; Maryvonne Rosseneu
Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter.
The Journal of biological chemistry 2004;279(36):37779-88.
2004: Frank Peelman; Wim Waelput; Hannes Iserentant; Delphine Lavens; Sven Eyckerman; Lennart Zabeau; Jan Tavernier
Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases.
Progress in lipid research 2004;43(4):283-301.
2004: Stein Roosbeek; Hans Caster; Qing Zhou Liu; Pierre-François Berne; Nicolas Duverger; Bart Christiaens; Joël Vandekerckhove; Frank Peelman; Christine Labeur; Maryvonne Rosseneu
Expression and activity of the nucleotide-binding domains of the human ABCA1 transporter.
Protein expression and purification 2004;35(1):102-10.
2003: Lennart Zabeau; Delphine Lavens; Frank Peelman; Sven Eyckerman; Joël Vandekerckhove; Jan Tavernier
The ins and outs of leptin receptor activation.
FEBS letters 2003;546(1):45-50.
2003: Frank Peelman; Christine Labeur; Berlinda Vanloo; Stein Roosbeek; Catherine Devaud; Nicolas Duverger; Patrice DENEFLE; Marie Rosier; Joël Vandekerckhove; Maryvonne Rosseneu
Characterization of the ABCA transporter subfamily: identification of prokaryotic and eukaryotic members, phylogeny and topology.
Journal of molecular biology 2003;325(2):259-74.
2001: Frank Peelman; Berlinda Vanloo; JL Verschelde; Christine Labeur; Hans Caster; J Taveirne; Annick Verhee; Nicolas Duverger; Joël Vandekerckhove; Jan Tavernier; Maryvonne Rosseneu
Effect of mutations of N- and C-terminal charged residues on the activity of LCAT.
Journal of lipid research 2001;42(4):471-9.
2001: C Desrumaux; Christine Labeur; Annick Verhee; Jan Tavernier; Joël Vandekerckhove; Maryvonne Rosseneu; Frank Peelman
A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins.
The Journal of biological chemistry 2001;276(8):5908-15.
2001: Stein Roosbeek; Berlinda Vanloo; Nicolas Duverger; Hans Caster; Joke Breyne; I De Beun; H Patel; Joël Vandekerckhove; Carol C Shoulders; Maryvonne Rosseneu; Frank Peelman
Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase.
Journal of lipid research 2001;42(1):31-40.
2000: H Liu; Philippa J Talmud; laurence lins; Robert Brasseur; G Olivecrona; Frank Peelman; Joël Vandekerckhove; Maryvonne Rosseneu; Christine Labeur
Characterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase.
Biochemistry 2000;39(31):9201-12.
2000: Bart Christiaens; Berlinda Vanloo; C Gouyette; I Van Vynckt; Hans Caster; J Taveirne; Annick Verhee; Christine Labeur; Frank Peelman; Joël Vandekerckhove; Jan Tavernier; Maryvonne Rosseneu
Headgroup specificity of lecithin cholesterol acyltransferase for monomeric and vesicular phospholipids.
Biochimica et biophysica acta 2000;1486(2-3):321-7.
2000: Berlinda Vanloo; Frank Peelman; K Deschuymere; J Taveirne; Annick Verhee; C Gouyette; Christine Labeur; Joël Vandekerckhove; Jan Tavernier; Maryvonne Rosseneu
Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease.
Journal of lipid research 2000;41(5):752-61.
2000: Frank Peelman; Joël Vandekerckhove; Maryvonne Rosseneu
Structure and function of lecithin cholesterol acyl transferase: new insights from structural predictions and animal models.
Current opinion in lipidology 2000;11(2):155-60.
1999: Frank Peelman; Berlinda Vanloo; O Perez-Mendez; A Decout; JL Verschelde; Christine Labeur; N Vinaimont; Annick Verhee; Nicolas Duverger; Robert Brasseur; Joël Vandekerckhove; Jan Tavernier; Maryvonne Rosseneu
Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT).
Protein engineering 1999;12(1):71-8.
1999: Frank Peelman; JL Verschelde; Berlinda Vanloo; Christophe Ampe; Christine Labeur; Jan Tavernier; Joël Vandekerckhove; Maryvonne Rosseneu
Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity.
Journal of lipid research 1999;40(1):59-69.
1998: O Pérez-Méndez; Berlinda Vanloo; A Decout; Marc Goethals; Frank Peelman; Joël Vandekerckhove; Robert Brasseur; Maryvonne Rosseneu
Contribution of the hydrophobicity gradient of an amphipathic peptide to its mode of association with lipids.
European journal of biochemistry / FEBS 1998;256(3):570-9.
1998: Frank Peelman; N Vinaimont; Annick Verhee; Berlinda Vanloo; JL Verschelde; Christine Labeur; S Seguret-Mace; Nicolas Duverger; G Hutchinson; Joël Vandekerckhove; Jan Tavernier; Maryvonne Rosseneu
A proposed architecture for lecithin cholesterol acyl transferase (LCAT): identification of the catalytic triad and molecular modeling.
Protein science : a publication of the Protein Society 1998;7(3):587-99.
1997: Frank Peelman; Marc Goethals; Berlinda Vanloo; Christine Labeur; Robert Brasseur; Joël Vandekerckhove; Maryvonne Rosseneu
Structural and functional properties of the 154-171 wild-type and variant peptides of human lecithin-cholesterol acyltransferase.
European journal of biochemistry / FEBS 1997;249(3):708-15.