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Anthony Pegg

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Physiology

DNA Repair

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Genes & Molecular Sequences

Amino Acid Sequences

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Tumor Cells, Cultured

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Publications

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Natalia Tretyakova; Susith Wickramaratne; Melissa Campion; Teshome B Gherezghiher; Sreenivas Kanugula; Jamie Kurtz; Erin D Michaelson-Richie; Xun Ming; Anthony E Pegg; Colin Campbell
DNA-Reactive Protein Monoepoxides Induce Cell Death and Mutagenesis in Mammalian Cells.
Dana-Lynn T Koomoa; Jan Koster; Ingo Lange; Anthony E Pegg; David J Feith; Dirk Geerts; André S Bachmann
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
David J Feith; Anthony E Pegg; Louise Y Y Fong
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.

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All Publications

2013: Natalia Tretyakova; Susith Wickramaratne; Melissa Campion; Teshome B Gherezghiher; Sreenivas Kanugula; Jamie Kurtz; Erin D Michaelson-Richie; Xun Ming; Anthony E Pegg; Colin Campbell
DNA-Reactive Protein Monoepoxides Induce Cell Death and Mutagenesis in Mammalian Cells.
Biochemistry 2013;52(18):3171-81.
2013: Dana-Lynn T Koomoa; Jan Koster; Ingo Lange; Anthony E Pegg; David J Feith; Dirk Geerts; André S Bachmann
DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.
International journal of oncology 2013;42(4):1219-28.
2013: David J Feith; Anthony E Pegg; Louise Y Y Fong
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
Carcinogenesis 2013;34(3):570-6.
2012: Emanuele Giordano; Rebecca A Hillary; Anthony E Pegg; Jianliang Song; Andrew D Sumner; Thomas C Vary; JuFang Wang; Xue-Qian Zhang; Claudio M Caldarera; Joseph Y Cheung; Lisa M Shantz
Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy.
Amino acids 2012;42(2-3):507-18.
2012: Chenxu Shi; Xiaojing Wang; Patricia A Welsh; Diane E McCloskey; Anthony E Pegg; Suzanne Sass-Kuhn; David J Feith
Characterization of transgenic mice with overexpression of spermidine synthase.
Amino acids 2012;42(2-3):495-505.
2011: Jolita Sečkutė; John A Secrist; H Jeanette Thomas; Diane E McCloskey; Anthony E Pegg; Steven E Ealick
Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.
Protein science : a publication of the Protein Society 2011;20(11):1836-44.
2011: Robert Green; Colin C Hanfrey; Sreenivas Kanugula; Diane E McCloskey; Anthony E Pegg; Xiaojing Wang; Katherine A Elliott; Anthony J Michael
Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation.
Molecular microbiology 2011;81(4):1109-24.
2011: Meredith K Chuk; Diane E Cole; Cynthia McCully; Natalia A Loktionova; Anthony E Pegg; Robert J Parker; Gary T Pauly; BRIGITTE WIDEMANN; FRANK BALIS; Elizabeth Fox
Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model.
Cancer chemotherapy and pharmacology 2011;67(6):1291-7.
2011: Anthony E Pegg
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.
Chemical research in toxicology 2011;24(5):618-39.
2011: Xiaojing Wang; Anthony E Pegg
Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine.
Methods in molecular biology (Clifton, N.J.) 2011;720():159-70.
2011: Anthony E Pegg; Xiaojing Wang; Charles E Schwartz; Diane E McCloskey
Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine.
The Biochemical journal 2011;433(1):139-44.
2010: Qingming Fang; Sreenivas Kanugula; Julie L Tubbs; John A Tainer; Anthony E Pegg
Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases.
The Journal of biological chemistry 2010;285(11):8185-95.
2010: Aley G Kalapila; Anthony E Pegg
Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells.
Mutation research 2010;684(1-2):35-42.
2010: Shridhar Bale; Kavita Baba; Diane E McCloskey; Anthony E Pegg; Steven E Ealick
Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 2):181-9.
2010: Anthony E Pegg; Anthony J Michael
Spermine synthase.
Cellular and molecular life sciences : CMLS 2010;67(1):113-21.
2009: Anthony E Pegg
Mammalian polyamine metabolism and function.
IUBMB life 2009;61(9):880-94.
2009: Li Li; Joana Perdigao; Anthony E Pegg; Yanbin Lao; Stephen S Hecht; Bruce R Lindgren; Joyce T Reardon; Aziz Sancar; Elizabeth V Wattenberg; Lisa A Peterson
The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines.
Chemical research in toxicology 2009;22(8):1464-72.
2009: Aley G Kalapila; Natalia A Loktionova; Anthony E Pegg
Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins.
Environmental and molecular mutagenesis 2009;50(6):502-14.
2009: Julie L Tubbs; Vitaly Latypov; Sreenivas Kanugula; Amna Butt; Manana Melikishvili; Rolf Kraehenbuehl; Oliver Fleck; Andrew Marriott; Amanda J Watson; Barbara Verbeek; Gail McGown; Mary Thorncroft; Mauro F Santibanez-Koref; Christopher Millington; Andrew S Arvai; Matthew D Kroeger; Lisa A Peterson; David M Williams; Michael G Fried; Geoffrey P Margison; Anthony E Pegg; John A Tainer
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Nature 2009;459(7248):808-13.
2009: Claire A Adams; Manana Melikishvili; David W Rodgers; Joseph J Rasimas; Anthony E Pegg; Michael G Fried
Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA.
Journal of molecular biology 2009;389(2):248-63.
2009: Anthony E Pegg; Xiaojing Wang
Mouse models to investigate the function of spermine.
Communicative & integrative biology 2009;2(3):271-4.
2009: Diane E McCloskey; Shridhar Bale; John A Secrist; Anita Tiwari; Thomas H Moss; Jacob Valiyaveettil; Wesley H Brooks; Wayne C Guida; Anthony E Pegg; Steven E Ealick
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Journal of medicinal chemistry 2009;52(5):1388-407.
2009: Xiaojing Wang; Snezana Levic; Michael Anne Gratton; Karen Jo Doyle; Ebenezer N Yamoah; Anthony E Pegg
Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
The Journal of biological chemistry 2009;284(2):930-7.
2009: Anthony E Pegg
S-Adenosylmethionine decarboxylase.
Essays in biochemistry 2009;46():25-45.
2008: Manana Melikishvili; Joseph J Rasimas; Anthony E Pegg; Michael G Fried
Interactions of human O(6)-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs.
Biochemistry 2008;47(52):13754-63.
2008: Subha Philip; Srividya Swaminathan; Sergey Kuznetsov; Sreenivas Kanugula; Kajal Biswas; Suhwan Chang; Natalia A Loktionova; Diana C Haines; Philipp Kaldis; Anthony E Pegg; Shyam K Sharan
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications.
Cancer research 2008;68(23):9973-81.
2008: Gary T Pauly; Natalia A Loktionova; Qingming Fang; Sai Lakshmana Vankayala; Wayne C Guida; Anthony E Pegg
Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
Journal of medicinal chemistry 2008;51(22):7144-53.
2008: Qingming Fang; Anne M Noronha; Sebastian P Murphy; Christopher J Wilds; Julie L Tubbs; John A Tainer; Goutam Chowdhury; F Peter Guengerich; Anthony E Pegg
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 2008;47(41):10892-903.
2008: Aley G Kalapila; Natalia A Loktionova; Anthony E Pegg
Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide.
Chemical research in toxicology 2008;21(9):1851-61.
2008: Hong Wu; Jinrong Min; Hong Zeng; Diane E McCloskey; Yoshihiko Ikeguchi; Peter Loppnau; Anthony J Michael; Anthony E Pegg; Alexander N Plotnikov
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
The Journal of biological chemistry 2008;283(23):16135-46.
2008: Anthony E Pegg
Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator.
American journal of physiology. Endocrinology and metabolism 2008;294(6):E995-1010.
2008: Gregory W deHart; Taihao Jin; Diane E McCloskey; Anthony E Pegg; Dean Sheppard
The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(20):7188-93.
2008: Erika V Soriano; Diane E McCloskey; Cynthia Kinsland; Anthony E Pegg; Steven E Ealick
Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 4):377-82.
2008: Rachel Loeber; Erin Michaelson; Qingming Fang; Colin Campbell; Anthony E Pegg; Natalia Tretyakova
Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards.
Chemical research in toxicology 2008;21(4):787-95.
2008: Shannon M Mumenthaler; Hong Yu; Sheila Tze; Stephen D Cederbaum; Anthony E Pegg; David Seligson; Wayne W Grody
Expression of arginase II in prostate cancer.
International journal of oncology 2008;32(2):357-65.
2008: Qingming Fang; Natalia A Loktionova; Robert C Moschel; Sahar Javanmard; Gary T Pauly; Anthony E Pegg
Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase.
Biochemical pharmacology 2008;75(3):618-26.
2007: Richard Coulter; Maureen Blandino; Jessica M Tomlinson; Gary T Pauly; Magdalena Krajewska; Robert C Moschel; Lisa A Peterson; Anthony E Pegg; Thomas E Spratt
Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase.
Chemical research in toxicology 2007;20(12):1966-71.
2007: Xiaojing Wang; David J Feith; Pat Welsh; Catherine S Coleman; Christina Lopez; Patrick M Woster; Thomas G O'Brien; Anthony E Pegg
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Carcinogenesis 2007;28(11):2404-11.
2007: Sahar Javanmard; Natalia A Loktionova; Qingming Fang; Gary T Pauly; Anthony E Pegg; Robert C Moschel
Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.
Journal of medicinal chemistry 2007;50(21):5193-201.
2007: Joshua L Deignan; Justin C Livesay; Lisa M Shantz; Anthony E Pegg; William E O'Brien; Ramaswamy Krishna Iyer; Stephen D Cederbaum; Wayne W Grody
Polyamine homeostasis in arginase knockout mice.
American journal of physiology. Cell physiology 2007;293(4):C1296-301.
2007: Ryan J Hansen; Susan M Ludeman; Sari J Paikoff; Anthony E Pegg; M Eileen Dolan
Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
DNA repair 2007;6(8):1145-54.
2007: Anthony E Pegg; Qingming Fang; Natalia A Loktionova
Human variants of O6-alkylguanine-DNA alkyltransferase.
DNA repair 2007;6(8):1071-8.
2007: David J Feith; Lisa M Shantz; Paula L Shoop; Kerry A Keefer; Chethana Prakashagowda; Anthony E Pegg
Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds.
Molecular carcinogenesis 2007;46(6):453-65.
2007: Anthony E Pegg; David J Feith
Polyamines and neoplastic growth.
Biochemical Society transactions 2007;35(Pt 2):295-9.
2007: Joseph J Rasimas; Sambit R Kar; Anthony E Pegg; Michael G Fried
Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs.
The Journal of biological chemistry 2007;282(5):3357-66.
2007: Liping Liu; Kengo Watanabe; Qingming Fang; Kevin M Williams; F Peter Guengerich; Anthony E Pegg
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
Chemical research in toxicology 2007;20(1):155-63.
2006: Anthony E Pegg
Regulation of ornithine decarboxylase.
The Journal of biological chemistry 2006;281(21):14529-32.
2006: Renée S Mijal; Sreenivas Kanugula; Choua C Vu; Qingming Fang; Anthony E Pegg; Lisa A Peterson
DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases.
Cancer research 2006;66(9):4968-74.
2006: Oleg Nisenberg; Anthony E Pegg; Patricia A Welsh; Kerry A Keefer; Lisa M Shantz
Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice.
The Biochemical journal 2006;393(Pt 1):295-302.
2005: Qingming Fang; Sreenivas Kanugula; Anthony E Pegg
Function of domains of human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 2005;44(46):15396-405.
2005: Renée S Mijal; Natalia A Loktionova; Choua C Vu; Anthony E Pegg; Lisa A Peterson
O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents.
Chemical research in toxicology 2005;18(10):1619-25.
2005: Jennifer A Quinn; Annick Desjardins; Jon D Weingart; Henry Brem; M Eileen Dolan; Shannon M Delaney; James J Vredenburgh; Jeremy Rich; Allan H Friedman; David A Reardon; John H Sampson; Anthony E Pegg; Robert C Moschel; Robert Birch; Roger E McLendon; James M Provenzale; Sridharan Gururangan; Janet E Dancey; Jill Maxwell; Sandra Tourt-Uhlig; James E Herndon; Darell D Bigner; Henry S Friedman
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):7178-87.
2005: Hong Zang; Qingming Fang; Anthony E Pegg; F Peter Guengerich
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.
The Journal of biological chemistry 2005;280(35):30873-81.
2005: Sreenivas Kanugula; Gary T Pauly; Robert C Moschel; Anthony E Pegg
A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3617-22.
2005: Joseph M Ackermann; Sreenivas Kanugula; Anthony E Pegg
DNAzyme-mediated silencing of ornithine decarboxylase.
Biochemistry 2005;44(6):2143-52.
2005: Guangping Wei; Natalia A Loktionova; Anthony E Pegg; Robert C Moschel
Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
Journal of medicinal chemistry 2005;48(1):256-61.
2004: Xiaojing Wang; Yoshihiko Ikeguchi; Diane E McCloskey; Paul Nelson; Anthony E Pegg
Spermine synthesis is required for normal viability, growth, and fertility in the mouse.
The Journal of biological chemistry 2004;279(49):51370-5.
2004: Nicole M Thomson; Renée S Mijal; Rebecca Ziegel; Nancy L Fleischer; Anthony E Pegg; Natalia Tretyakova; Lisa A Peterson
Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine.
Chemical research in toxicology 2004;17(12):1600-6.
2004: Catherine S Coleman; Bruce Stanley; A Daniel Jones; Anthony E Pegg
Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism.
The Biochemical journal 2004;384(Pt 1):139-48.
2004: Victor Levin; Jacob L Jochec; Lisa M Shantz; Patricia E Koch; Anthony E Pegg
Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(11):1467-74.
2004: Manny Bacolod; Stewart P Johnson; Anthony E Pegg; M Eileen Dolan; Robert C Moschel; Nancy S Bullock; Qingming Fang; O Michael Colvin; Paul Modrich; Darell D Bigner; Henry S Friedman
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Molecular cancer therapeutics 2004;3(9):1127-35.
2004: Rahul Shah; Catherine S Coleman; Kiran Mir; Jeffrey Baldwin; James L Van Etten; Nick V Grishin; Anthony E Pegg; Bruce Stanley; Margaret A Phillips
Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases.
The Journal of biological chemistry 2004;279(34):35760-7.
2004: Uimook Choi; Suk See DeRavin; Kouhei Yamashita; Narda L Whiting-Theobald; Gilda F Linton; Natalia A Loktionova; Anthony E Pegg; Harry L Malech
Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker.
Experimental hematology 2004;32(8):709-19.
2004: Yoshihiko Ikeguchi; Xiaojing Wang; Diane E McCloskey; Catherine S Coleman; Paul Nelson; Guirong Hu; Lisa M Shantz; Anthony E Pegg
Characterization of transgenic mice with widespread overexpression of spermine synthase.
The Biochemical journal 2004;381(Pt 3):701-7.
2004: Michael E Nelson; Natalia A Loktionova; Anthony E Pegg; Robert C Moschel
2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase.
Journal of medicinal chemistry 2004;47(15):3887-91.
2004: J Gerardo Valadez; Liping Liu; Natalia A Loktionova; Anthony E Pegg; F Peter Guengerich
Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
Chemical research in toxicology 2004;17(7):972-82.
2004: Liping Liu; Kevin M Williams; F Peter Guengerich; Anthony E Pegg
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
Chemical research in toxicology 2004;17(6):742-52.
2004: Catherine S Coleman; Guirong Hu; Anthony E Pegg
Putrescine biosynthesis in mammalian tissues.
The Biochemical journal 2004;379(Pt 3):849-55.
2004: Renée S Mijal; Nicole M Thomson; Nancy L Fleischer; Gary T Pauly; Robert C Moschel; Sreenivas Kanugula; Qingming Fang; Anthony E Pegg; Lisa A Peterson
The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
Chemical research in toxicology 2004;17(3):424-34.
2004: Liping Liu; David L Hachey; Gerardo Valadez; Kevin M Williams; F Peter Guengerich; Natalia A Loktionova; Sreenivas Kanugula; Anthony E Pegg
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
The Journal of biological chemistry 2004;279(6):4250-9.
2004: Joseph J Rasimas; Paula A Dalessio; Ira J Ropson; Anthony E Pegg; Michael G Fried
Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase.
Protein science : a publication of the Protein Society 2004;13(1):301-5.
2003: Aviva S Meyer; Melodie D McCain; Qingming Fang; Anthony E Pegg; Thomas E Spratt
O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics.
Chemical research in toxicology 2003;16(11):1405-9.
2003: Sreenivas Kanugula; Anthony E Pegg
Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus.
The Biochemical journal 2003;375(Pt 2):449-55.
2003: F Peter Guengerich; Qingming Fang; Liping Liu; David L Hachey; Anthony E Pegg
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
Biochemistry 2003;42(37):10965-70.
2003: Demetrius M Kokkinakis; M Ahmed Mansoor; Damodaran Chendil; Robert C Moschel; Anthony E Pegg
Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3801-7.
2003: Yoshihiko Ikeguchi; Caroline A Mackintosh; Diane E McCloskey; Anthony E Pegg
Effect of spermine synthase on the sensitivity of cells to anti-tumour agents.
The Biochemical journal 2003;373(Pt 3):885-92.
2003: Louise Y Y Fong; David J Feith; Anthony E Pegg
Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis.
Cancer research 2003;63(14):3945-54.
2003: Diane E McCloskey; Anthony E Pegg
Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine.
The Journal of biological chemistry 2003;278(16):13881-7.
2003: Rebecca A Hillary; Anthony E Pegg
Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide.
Biochimica et biophysica acta 2003;1647(1-2):161-6.
2003: Anthony E Pegg; David J Feith; Louise Y Y Fong; Catherine S Coleman; Thomas G O'Brien; Lisa M Shantz
Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth.
Biochemical Society transactions 2003;31(2):356-60.
2003: Joseph J Rasimas; Anthony E Pegg; Michael G Fried
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.
The Journal of biological chemistry 2003;278(10):7973-80.
2003: Joseph J Rasimas; Sreenivas Kanugula; Paula M Dalessio; Ira J Ropson; Michael G Fried; Anthony E Pegg
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 2003;42(4):980-90.
2003: Joseph M Ackermann; Anthony E Pegg; Diane E McCloskey
Drugs affecting the cell cycle via actions on the polyamine metabolic pathway.
Progress in cell cycle research 2003;5():461-8.
2002: Liping Liu; Anthony E Pegg; Kevin M Williams; F Peter Guengerich
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
The Journal of biological chemistry 2002;277(40):37920-8.
2002: Henry S Friedman; Stephen T Keir; Anthony E Pegg; Peter J Houghton; O Michael Colvin; Robert C Moschel; Darell D Bigner; M Eileen Dolan
O6-benzylguanine-mediated enhancement of chemotherapy.
Molecular cancer therapeutics 2002;1(11):943-8.
2002: Kieu X Luu; Sreenivas Kanugula; Anthony E Pegg; Gary T Pauly; Robert C Moschel
Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase.
Biochemistry 2002;41(27):8689-97.
2002: Liping Liu; Meng Xu-Welliver; Sreenivas Kanugula; Anthony E Pegg
Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide.
Cancer research 2002;62(11):3037-43.
2002: Meng Xu-Welliver; Anthony E Pegg
Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase.
Carcinogenesis 2002;23(5):823-30.
2002: Jennifer A Quinn; James Pluda; M Eileen Dolan; Shannon M Delaney; Richard S. Kaplan; Jeremy Rich; Allan H Friedman; David A Reardon; John H Sampson; O Michael Colvin; Michael M Haglund; Anthony E Pegg; Robert C Moschel; Roger E McLendon; James M Provenzale; Sridharan Gururangan; Sandra Tourt-Uhlig; James E Herndon; Darell D Bigner; Henry S Friedman
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(9):2277-83.
2002: Natalia A Loktionova; Anthony E Pegg
Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine.
Biochemical pharmacology 2002;63(8):1431-42.
2002: Lisa M Shantz; Yongjun Guo; Janet A Sawicki; Anthony E Pegg; Thomas G O'Brien
Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation.
Carcinogenesis 2002;23(4):657-64.
2002: Catherine S Coleman; Anthony E Pegg; Louis C Megosh; Yongjun Guo; Janet A Sawicki; Thomas G O'Brien
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
Carcinogenesis 2002;23(2):359-64.
2001: PM Bauer; Georgette M Buga; Jon M Fukuto; Anthony E Pegg; Louis J Ignarro
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
The Journal of biological chemistry 2001;276(37):34458-64.
2001: David J Feith; Lisa M Shantz; Anthony E Pegg
Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis.
Cancer research 2001;61(16):6073-81.
2001: Catherine S Coleman; Anthony E Pegg
Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.
The Biochemical journal 2001;358(Pt 1):137-45.
2001: Lisa M Shantz; David J Feith; Anthony E Pegg
Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy.
The Biochemical journal 2001;358(Pt 1):25-32.
2001: Louise Y Y Fong; Vu T Nguyen; Anthony E Pegg; PN Magee
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001;10(3):191-9.
2001: Anthony E Pegg; K Goodtzova; Natalia A Loktionova; Sreenivas Kanugula; Gary T Pauly; Robert C Moschel
Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine.
The Journal of pharmacology and experimental therapeutics 2001;296(3):958-65.
2001: Demetrius M Kokkinakis; Dora Bocangel; S Clifford Schold; Robert C Moschel; Anthony E Pegg
Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):421-8.
2001: Sreenivas Kanugula; Anthony E Pegg
Novel DNA repair alkyltransferase from Caenorhabditis elegans.
Environmental and molecular mutagenesis 2001;38(2-3):235-43.
2000: Anatoli N Lopatin; Lisa M Shantz; Caroline A Mackintosh; Colin G Nichols; Anthony E Pegg
Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis.
Journal of molecular and cellular cardiology 2000;32(11):2007-24.
2000: Henry S Friedman; James Pluda; Jennifer A Quinn; Reginald Ewesuedo; L Long; Allan H Friedman; Ilkcan Cokgor; O Michael Colvin; Michael M Haglund; DM Ashley; Jeremy Rich; J Sampson; Anthony E Pegg; Robert C Moschel; Roger E McLendon; James M Provenzale; ES Stewart; Sandra Tourt-Uhlig; AM Garcia-Turner; James E Herndon; Darell D Bigner; M Eileen Dolan
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(20):3522-8.
2000: Caroline A Mackintosh; Anthony E Pegg
Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea.
The Biochemical journal 2000;351 Pt 2():439-47.
2000: Vikas J Patel; GB Elion; Peter J Houghton; Stephen T Keir; Anthony E Pegg; Stewart P Johnson; M Eileen Dolan; Darell D Bigner; Henry S Friedman
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4154-7.
2000: Y Cai; Michael H Wu; M Xu-Welliver; Anthony E Pegg; Susan M Ludeman; M Eileen Dolan
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Cancer research 2000;60(19):5464-9.
2000: Caroline A Mackintosh; David J Feith; Lisa M Shantz; Anthony E Pegg
Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.
The Biochemical journal 2000;350 Pt 3():645-53.
2000: Diane E McCloskey; Anthony E Pegg
Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues.
The Journal of biological chemistry 2000;275(37):28708-14.
2000: H Liu; Meng Xu-Welliver; Anthony E Pegg
The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli.
Mutation research 2000;452(1):1-10.
2000: Meng Xu-Welliver; Sreenivas Kanugula; Natalia A Loktionova; T M Crone; Anthony E Pegg
Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
The Biochemical journal 2000;347(Pt 2):527-34.
2000: Meng Xu-Welliver; Anthony E Pegg
Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.
The Biochemical journal 2000;347(Pt 2):519-26.
2000: Anthony E Pegg
Repair of O(6)-alkylguanine by alkyltransferases.
Mutation research 2000;462(2-3):83-100.
2000: María Teresa Olmo; José Luis Urdiales; Anthony E Pegg; Miguel Angel Medina; Francisca Sánchez-Jiménez
In vitro study of proteolytic degradation of rat histidine decarboxylase.
European journal of biochemistry / FEBS 2000;267(5):1527-31.
2000: Stephen T Keir; M Eileen Dolan; Anthony E Pegg; AA Lawless; Robert C Moschel; Darell D Bigner; Henry S Friedman
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
Cancer chemotherapy and pharmacology 2000;45(6):437-40.
2000: Demetrius M Kokkinakis; Robert C Moschel; Anthony E Pegg; S Clifford Schold
Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
Cancer chemotherapy and pharmacology 2000;45(1):69-77.
1999: H Xiong; Anthony E Pegg
Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate.
The Journal of biological chemistry 1999;274(49):35059-66.
1999: Demetrius M Kokkinakis; Robert C Moschel; Anthony E Pegg; S Clifford Schold
Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3676-81.
1999: Meng Xu-Welliver; J Leitão; Sreenivas Kanugula; William J Meehan; Anthony E Pegg
Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.
Biochemical pharmacology 1999;58(8):1279-85.
1999: PM Bauer; Jon M Fukuto; Georgette M Buga; Anthony E Pegg; Louis J Ignarro
Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation.
Biochemical and biophysical research communications 1999;262(2):355-8.
1999: Natalia A Loktionova; Meng Xu-Welliver; T M Crone; Sreenivas Kanugula; Anthony E Pegg
Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
Biochemical pharmacology 1999;58(2):237-44.
1999: Thomas E Spratt; J D Wu; DE Levy; S Kanugula; Anthony E Pegg
Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 1999;38(21):6801-6.
1999: Meng Xu-Welliver; J Leitão; Sreenivas Kanugula; Anthony E Pegg
Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
Cancer research 1999;59(7):1514-9.
1999: Diane E McCloskey; Catherine S Coleman; Anthony E Pegg
Properties and regulation of human spermidine/spermine N1-acetyltransferase stably expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 1999;274(10):6175-82.
1999: H Xiong; Bruce Stanley; Anthony E Pegg
Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase.
Biochemistry 1999;38(8):2462-70.
1999: L Wang; Thomas E Spratt; Anthony E Pegg; Lisa A Peterson
Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase.
Chemical research in toxicology 1999;12(2):127-31.
1999: Anthony E Pegg
DNA repair pathways and cancer prevention.
Advances in experimental medicine and biology 1999;472():253-67.
1999: Lisa M Shantz; Anthony E Pegg
Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway.
The international journal of biochemistry & cell biology 1999;31(1):107-22.
1999: S Edara; Sreenivas Kanugula; Anthony E Pegg
Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1999;20(1):103-8.
1999: Henry S Friedman; Anthony E Pegg; Stewart P Johnson; Natalia A Loktionova; M Eileen Dolan; Paul Modrich; Robert C Moschel; Robert F Struck; T P Brent; Susan M Ludeman; Nancy S Bullock; C Kilborn; Stephen T Keir; Q Dong; Darell D Bigner; O Michael Colvin
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
Cancer chemotherapy and pharmacology 1999;43(1):80-5.
1998: Louise Y Y Fong; Anthony E Pegg; PN Magee
Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: effects on esophageal cell proliferation and apoptosis.
Cancer research 1998;58(23):5380-8.
1998: Anthony E Pegg; H Xiong; David J Feith; Lisa M Shantz
S-adenosylmethionine decarboxylase: structure, function and regulation by polyamines.
Biochemical Society transactions 1998;26(4):580-6.
1998: Henry S Friedman; Demetrius M Kokkinakis; James Pluda; Allan H Friedman; Ilkcan Cokgor; Michael M Haglund; DM Ashley; Jeremy Rich; M Eileen Dolan; Anthony E Pegg; Robert C Moschel; Roger E McLendon; T Kerby; James E Herndon; Darell D Bigner; S Clifford Schold
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(11):3570-5.
1998: K Goodtzova; Sreenivas Kanugula; S Edara; Anthony E Pegg
Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase.
Biochemistry 1998;37(36):12489-95.
1998: José M Matés; Alicia Esteban del Valle; José Luis Urdiales; C S Coleman; David J Feith; María Teresa Olmo; Anthony E Pegg; Francisca Sánchez-Jiménez
Structure/function relationship studies on the T/S residues 173-177 of rat ODC.
Biochimica et biophysica acta 1998;1386(1):113-20.
1998: Lisa M Shantz; Anthony E Pegg
Ornithine decarboxylase induction in transformation by H-Ras and RhoA.
Cancer research 1998;58(13):2748-53.
1998: M Eileen Dolan; S K Roy; B J Garbiras; Paul R Helft; P Paras; M Y Chae; Robert C Moschel; Anthony E Pegg
O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
Biochemical pharmacology 1998;55(10):1701-9.
1998: Meng Xu-Welliver; Sreenivas Kanugula; Anthony E Pegg
Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.
Cancer research 1998;58(9):1936-45.
1998: Anthony E Pegg; Sreenivas Kanugula; S Edara; Gary T Pauly; Robert C Moschel; K Goodtzova
Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.
The Journal of biological chemistry 1998;273(18):10863-7.
1998: Sreenivas Kanugula; K Goodtzova; Anthony E Pegg
Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis.
The Biochemical journal 1998;329 ( Pt 3)():545-50.
1998: L Wiest; Anthony E Pegg
Assay of spermidine and spermine synthases.
Methods in molecular biology (Clifton, N.J.) 1998;79():51-7.
1998: Lisa M Shantz; Anthony E Pegg
Assay of mammalian S-adenosylmethionine decarboxylase activity.
Methods in molecular biology (Clifton, N.J.) 1998;79():45-9.
1998: Catherine S Coleman; Anthony E Pegg
Assay of mammalian ornithine decarboxylase activity using [14C]ornithine.
Methods in molecular biology (Clifton, N.J.) 1998;79():41-4.
1997: R H Hu; Anthony E Pegg
Rapid induction of apoptosis by deregulated uptake of polyamine analogues.
The Biochemical journal 1997;328 ( Pt 1)():307-16.
1997: H Xiong; Bruce Stanley; B L Tekwani; Anthony E Pegg
Processing of mammalian and plant S-adenosylmethionine decarboxylase proenzymes.
The Journal of biological chemistry 1997;272(45):28342-8.
1997: M Eileen Dolan; Anthony E Pegg
O6-benzylguanine and its role in chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(6):837-47.
1997: Anthony E Pegg; L Chung; Robert C Moschel
Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives.
Biochemical pharmacology 1997;53(10):1559-64.
1997: Catherine S Coleman; Anthony E Pegg
Proteasomal degradation of spermidine/spermine N1-acetyltransferase requires the carboxyl-terminal glutamic acid residues.
The Journal of biological chemistry 1997;272(18):12164-9.
1997: L Wang; Thomas E Spratt; X K Liu; Stephen S Hecht; Anthony E Pegg; Lisa A Peterson
Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.
Chemical research in toxicology 1997;10(5):562-7.
1997: K Goodtzova; Sreenivas Kanugula; S Edara; Gary T Pauly; Robert C Moschel; Anthony E Pegg
Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases.
The Journal of biological chemistry 1997;272(13):8332-9.
1997: Y Nishikawa; S Kar; L Wiest; Anthony E Pegg; Brian I Carr
Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells.
The Biochemical journal 1997;321 ( Pt 2)():537-43.
1996: S Edara; Sreenivas Kanugula; K Goodtzova; Anthony E Pegg
Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.
Cancer research 1996;56(24):5571-5.
1996: Michael G Fried; Sreenivas Kanugula; J L Bromberg; Anthony E Pegg
DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability.
Biochemistry 1996;35(48):15295-301.
1996: Lisa M Shantz; Catherine S Coleman; Anthony E Pegg
Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.
Cancer research 1996;56(22):5136-40.
1996: Lisa M Shantz; R H Hu; Anthony E Pegg
Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E.
Cancer research 1996;56(14):3265-9.
1996: Catherine S Coleman; H Huang; Anthony E Pegg
Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase.
The Biochemical journal 1996;316 ( Pt 3)():697-701.
1996: R Wu; N H Saab; H Huang; L Wiest; Anthony E Pegg; Robert A Casero; Patrick M Woster
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.
Bioorganic & medicinal chemistry 1996;4(6):825-36.
1996: T M Crone; K Goodtzova; Anthony E Pegg
Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.
Mutation research 1996;363(1):15-25.
1996: Demetrius M Kokkinakis; Robert C Moschel; T H Vuong; M V Reddy; S Clifford Schold; Anthony E Pegg
Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism.
In vivo (Athens, Greece) 1996;10(3):297-306.
1996: S Clifford Schold; Demetrius M Kokkinakis; J L Rudy; Robert C Moschel; Anthony E Pegg
Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.
Cancer research 1996;56(9):2076-81.
1996: N A Loktionova; Anthony E Pegg
Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
Cancer research 1996;56(7):1578-83.
1995: Catherine S Coleman; H Huang; Anthony E Pegg
Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine.
Biochemistry 1995;34(41):13423-30.
1995: Anthony E Pegg; K Swenn; M Y Chae; M Eileen Dolan; Robert C Moschel
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
Biochemical pharmacology 1995;50(8):1141-8.
1995: G M Ciocco; Robert C Moschel; M Y Chae; P J McLaughlin; I S Zagon; Anthony E Pegg
Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine.
Cancer research 1995;55(18):4085-91.
1995: Anthony E Pegg; R H Hu
Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation.
Cancer letters 1995;95(1-2):247-52.
1995: T M Crone; Sreenivas Kanugula; Anthony E Pegg
Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine.
Carcinogenesis 1995;16(8):1687-92.
1995: J R Lakanen; Anthony E Pegg; James K Coward
Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase.
Journal of medicinal chemistry 1995;38(14):2714-27.
1995: Henry S Friedman; M Eileen Dolan; Anthony E Pegg; S Marcelli; Stephen T Keir; J J Catino; Darell D Bigner; S Clifford Schold
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
Cancer research 1995;55(13):2853-7.
1995: S Edara; K Goodtzova; Anthony E Pegg
The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.
Carcinogenesis 1995;16(7):1637-42.
1995: Sreenivas Kanugula; K Goodtzova; S Edara; Anthony E Pegg
Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine.
Biochemistry 1995;34(21):7113-9.
1995: Anthony E Pegg; R Poulin; James K Coward
Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function.
The international journal of biochemistry & cell biology 1995;27(5):425-42.
1995: L Parry; J Lopez-Ballester; L Wiest; Anthony E Pegg
Effect of expression of human spermidine/spermine N1-acetyltransferase in Escherichia coli.
Biochemistry 1995;34(8):2701-9.
1995: M Y Chae; K Swenn; Sreenivas Kanugula; M Eileen Dolan; Anthony E Pegg; Robert C Moschel
8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
Journal of medicinal chemistry 1995;38(2):359-65.
1995: L Parry; R Balaña Fouce; Anthony E Pegg
Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine.
The Biochemical journal 1995;305 ( Pt 2)():451-8.
1995: Anthony E Pegg; Lisa M Shantz; Catherine S Coleman
Ornithine decarboxylase as a target for chemoprevention.
Journal of cellular biochemistry. Supplement 1995;22():132-8.
1995: Anthony E Pegg; M Eileen Dolan; Robert C Moschel
Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.
Progress in nucleic acid research and molecular biology 1995;51():167-223.
1994: T M Crone; K Goodtzova; S Edara; Anthony E Pegg
Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
Cancer research 1994;54(23):6221-7.
1994: Anthony E Pegg; Lisa M Shantz; Catherine S Coleman
Ornithine decarboxylase: structure, function and translational regulation.
Biochemical Society transactions 1994;22(4):846-52.
1994: Demetrius M Kokkinakis; Robert C Moschel; Anthony E Pegg; M E Dolan; S Clifford Schold
Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.
Chemical research in toxicology 1994;7(6):762-9.
1994: T L Byers; J R Lakanen; James K Coward; Anthony E Pegg
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
The Biochemical journal 1994;303 ( Pt 2)():363-8.
1994: Tim E Byers; R S Wechter; R H Hu; Anthony E Pegg
Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures.
The Biochemical journal 1994;303 ( Pt 1)():89-96.
1994: M Eileen Dolan; M Y Chae; Anthony E Pegg; J H Mullen; Henry S Friedman; Robert C Moschel
Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
Cancer research 1994;54(19):5123-30.
1994: Lisa M Shantz; R Viswanath; Anthony E Pegg
Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine.
The Biochemical journal 1994;302 ( Pt 3)():765-72.
1994: Robert A Casero; Edward Gabrielson; Anthony E Pegg
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Cancer research 1994;54(15):3955-8.
1994: K Goodtzova; T M Crone; Anthony E Pegg
Activation of human O6-alkylguanine-DNA alkyltransferase by DNA.
Biochemistry 1994;33(28):8385-90.
1994: Lisa M Shantz; Anthony E Pegg
Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.
Cancer research 1994;54(9):2313-6.
1994: Bruce Stanley; Lisa M Shantz; Anthony E Pegg
Expression of mammalian S-adenosylmethionine decarboxylase in Escherichia coli. Determination of sites for putrescine activation of activity and processing.
The Journal of biological chemistry 1994;269(11):7901-7.
1994: M Y Chae; M G McDougall; M Eileen Dolan; K Swenn; Anthony E Pegg; Robert C Moschel
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
Journal of medicinal chemistry 1994;37(3):342-7.
1994: Catherine S Coleman; Bruce Stanley; R Viswanath; Anthony E Pegg
Rapid exchange of subunits of mammalian ornithine decarboxylase.
The Journal of biological chemistry 1994;269(5):3155-8.
1994: M Eileen Dolan; Anthony E Pegg; Robert C Moschel; B R Vishnuvajjala; K P Flora; M R Grever; Henry S Friedman
Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
Cancer chemotherapy and pharmacology 1994;35(2):121-6.
1993: Catherine S Coleman; Bruce Stanley; Anthony E Pegg
Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors.
The Journal of biological chemistry 1993;268(33):24572-9.
1993: Anthony E Pegg; M Boosalis; Leona D Samson; Robert C Moschel; T L Byers; K Swenn; M Eileen Dolan
Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
Biochemistry 1993;32(45):11998-2006.
1993: T M Crone; Anthony E Pegg
A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.
Cancer research 1993;53(20):4750-3.
1993: Anthony E Pegg; James K Coward
Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents.
Biochemical pharmacology 1993;46(4):717-24.
1993: M Eileen Dolan; Anthony E Pegg; Robert C Moschel; G B Grindey
Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Biochemical pharmacology 1993;46(2):285-90.
1993: Robert A Casero; Anthony E Pegg
Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(8):653-61.
1993: R Poulin; James K Coward; J R Lakanen; Anthony E Pegg
Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress.
The Journal of biological chemistry 1993;268(7):4690-8.
1993: T L Byers; L Wiest; R S Wechter; Anthony E Pegg
Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells.
The Biochemical journal 1993;290 ( Pt 1)():115-21.
1993: M Eileen Dolan; Anthony E Pegg; N D Biser; Robert C Moschel; H F English
Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
Cancer chemotherapy and pharmacology 1993;32(3):221-5.
1992: Madhubala rentala; Anthony E Pegg
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase synthesis by antisense oligodeoxynucleotides.
Molecular and cellular biochemistry 1992;118(2):191-5.
1992: Henry S Friedman; M Eileen Dolan; Robert C Moschel; Anthony E Pegg; G M Felker; Jeremy Rich; Darell D Bigner; S Clifford Schold
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Journal of the National Cancer Institute 1992;84(24):1926-31.
1992: Lisa M Shantz; I Holm; O A Jänne; Anthony E Pegg
Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content.
The Biochemical journal 1992;288 ( Pt 2)():511-8.
1992: Anthony E Pegg; P P McCann
S-adenosylmethionine decarboxylase as an enzyme target for therapy.
Pharmacology & therapeutics 1992;56(3):359-77.
1992: Anthony E Pegg; Bruce Stanley; L Wiest; Robert A Casero
Nucleotide sequence of hamster spermidine/spermine-N1-acetyltransferase cDNA.
Biochimica et biophysica acta 1992;1171(1):106-8.
1992: Robert C Moschel; M G McDougall; M Eileen Dolan; L Stine; Anthony E Pegg
Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.
Journal of medicinal chemistry 1992;35(23):4486-91.
1992: B L Tekwani; C J Bacchi; Anthony E Pegg
Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei.
Molecular and cellular biochemistry 1992;117(1):53-61.
1992: T L Byers; B Ganem; Anthony E Pegg
Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.
The Biochemical journal 1992;287 ( Pt 3)():717-24.
1992: B L Tekwani; C J Bacchi; J A Secrist; Anthony E Pegg
Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues.
Biochemical pharmacology 1992;44(5):905-11.
1992: Lisa M Shantz; Bruce Stanley; J A Secrist; Anthony E Pegg
Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine.
Biochemistry 1992;31(29):6848-55.
1992: B L Tekwani; Bruce Stanley; Anthony E Pegg
Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA.
Biochimica et biophysica acta 1992;1130(2):221-3.
1992: Anthony E Pegg; T L Byers
Repair of DNA containing O6-alkylguanine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(6):2302-10.
1992: J R Lakanen; James K Coward; Anthony E Pegg
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.
Journal of medicinal chemistry 1992;35(4):724-34.
1992: R Poulin; L Lu; B Ackermann; P Bey; Anthony E Pegg
Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites.
The Journal of biological chemistry 1992;267(1):150-8.
1991: M Eileen Dolan; Anthony E Pegg; L L Dumenco; Robert C Moschel; S L Gerson
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
Carcinogenesis 1991;12(12):2305-9.
1991: Bruce Stanley; Anthony E Pegg
Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity.
The Journal of biological chemistry 1991;266(28):18502-6.
1991: Anthony E Pegg; L Wiest; C Mummert; L Stine; Robert C Moschel; M Eileen Dolan
Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1991;12(9):1679-83.
1991: Anthony E Pegg; L Wiest; C Mummert; M Eileen Dolan
Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts.
Carcinogenesis 1991;12(9):1671-7.
1991: L Xiao; P Celano; A R Mank; Anthony E Pegg; Robert A Casero
Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase.
Biochemical and biophysical research communications 1991;179(1):407-15.
1991: L Lu; Bruce Stanley; Anthony E Pegg
Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover.
The Biochemical journal 1991;277 ( Pt 3)():671-5.
1991: M Eileen Dolan; R B Mitchell; C Mummert; Robert C Moschel; Anthony E Pegg
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
Cancer research 1991;51(13):3367-72.
1991: R Poulin; R S Wechter; Anthony E Pegg
An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress.
The Journal of biological chemistry 1991;266(10):6142-51.
1991: Anthony E Pegg; S Nagarajan; S Naficy; B Ganem
Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells.
The Biochemical journal 1991;274 ( Pt 1)():167-71.
1991: Robert A Casero; P Celano; S J Ervin; N B Applegren; L Wiest; Anthony E Pegg
Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase.
The Journal of biological chemistry 1991;266(2):810-4.
1991: Anthony E Pegg
Factors influencing carcinogenesis by alkylating agents.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;122():22-32.
1990: Anthony E Pegg
Properties of mammalian O6-alkylguanine-DNA transferases.
Mutation research 1990;233(1-2):165-75.
1990: Anthony E Pegg
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
Cancer research 1990;50(19):6119-29.
1990: Robert A Casero; P Celano; S J Ervin; L Wiest; Anthony E Pegg
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
The Biochemical journal 1990;270(3):615-20.
1990: M Eileen Dolan; Robert C Moschel; Anthony E Pegg
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5368-72.
1990: T L Byers; Anthony E Pegg
Regulation of polyamine transport in Chinese hamster ovary cells.
Journal of cellular physiology 1990;143(3):460-7.
1990: Anthony E Pegg; R Pakala; R J Bergeron
Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds.
The Biochemical journal 1990;267(2):331-8.
1990: R Poulin; Anthony E Pegg
Regulation of ornithine decarboxylase expression by anisosmotic shock in alpha-difluoromethylornithine-resistant L1210 cells.
The Journal of biological chemistry 1990;265(7):4025-32.
1990: M Eileen Dolan; L Stine; R B Mitchell; Robert C Moschel; Anthony E Pegg
Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Cancer communications 1990;2(11):371-7.
1989: Bruce Stanley; Anthony E Pegg; I Holm
Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase proenzyme.
The Journal of biological chemistry 1989;264(35):21073-9.
1989: D Eugene Rannels; R Kameji; Anthony E Pegg; Stephen R Rannels
Spermidine uptake by type II pneumocytes: interactions of amine uptake pathways.
The American journal of physiology 1989;257(6 Pt 1):L346-53.
1989: T L Byers; R Wechter; M E Nuttall; Anthony E Pegg
Expression of a human gene for polyamine transport in Chinese-hamster ovary cells.
The Biochemical journal 1989;263(3):745-52.
1989: Anthony E Pegg; R Wechter; R Poulin; Patrick M Woster; James K Coward
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.
Biochemistry 1989;28(21):8446-53.
1989: S Choudhury; Anthony E Pegg; JW Kreider; D R Mayo; Mary K Howett
Administration of ethylnitrosourea to neonate hamsters increases growth and frequency of SV40-induced fibrosarcomas.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1989;192(1):72-7.
1989: R Poulin; J A Secrist; Anthony E Pegg
Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells.
The Biochemical journal 1989;263(1):215-21.
1989: T L Byers; Anthony E Pegg
Properties and physiological function of the polyamine transport system.
The American journal of physiology 1989;257(3 Pt 1):C545-53.
1989: M Eileen Dolan; L Norbeck; C Clyde; N K Hora; L C Erickson; Anthony E Pegg
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Carcinogenesis 1989;10(9):1613-9.
1989: Anthony E Pegg; R Wechter; R Pakala; R J Bergeron
Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells.
The Journal of biological chemistry 1989;264(20):11744-9.
1989: M Eileen Dolan; G L Larkin; H F English; Anthony E Pegg
Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
Cancer chemotherapy and pharmacology 1989;25(2):103-8.
1989: R Kameji; Stephen R Rannels; Anthony E Pegg; D Eugene Rannels
Spermidine uptake by type II pulmonary epithelial cells in primary culture.
The American journal of physiology 1989;256(1 Pt 1):C160-7.
1988: A Pajunen; A Crozat; O A Jänne; R Ihalainen; P H Laitinen; B Stanley; Madhubala rentala; Anthony E Pegg
Structure and regulation of mammalian S-adenosylmethionine decarboxylase.
The Journal of biological chemistry 1988;263(32):17040-9.
1988: M Eileen Dolan; M Oplinger; Anthony E Pegg
Sequence specificity of guanine alkylation and repair.
Carcinogenesis 1988;9(11):2139-43.
1988: Thomas J McGarrity; Laurie P Peiffer; P C Colony; Anthony E Pegg
The effects of chronic ethanol administration on polyamine content during dimethylhydrazine-induced colorectal carcinogenesis in the rat.
Carcinogenesis 1988;9(11):2093-8.
1988: Madhubala rentala; J A Secrist; Anthony E Pegg
Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells.
The Biochemical journal 1988;254(1):45-50.
1988: Anthony E Pegg; Madhubala rentala; T Kameji; R J Bergeron
Control of ornithine decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues.
The Journal of biological chemistry 1988;263(22):11008-14.
1988: M Eileen Dolan; Anthony E Pegg; N K Hora; L C Erickson
Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Cancer research 1988;48(13):3603-6.
1988: Anthony E Pegg; J A Secrist; Madhubala rentala
Properties of L1210 cells resistant to alpha-difluoromethylornithine.
Cancer research 1988;48(10):2678-82.
1988: Anthony E Pegg; D B Jones; J A Secrist
Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.
Biochemistry 1988;27(5):1408-15.
1988: M Eileen Dolan; D Scicchitano; Anthony E Pegg
Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.
Cancer research 1988;48(5):1184-8.
1988: M Eileen Dolan; M Oplinger; Anthony E Pegg
Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion.
Mutation research 1988;193(2):131-7.
1988: Anthony E Pegg
Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.
Cancer research 1988;48(4):759-74.
1988: Anthony E Pegg; L Wiest; A Pajunen
Detection of proenzyme form of S-adenosylmethionine decarboxylase in extracts from rat prostate.
Biochemical and biophysical research communications 1988;150(2):788-93.
1988: Anthony E Pegg; T Kameji; A Shirahata; B Stanley; Madhubala rentala; A Pajunen
Regulation of mammalian S-adenosylmethionine decarboxylase.
Advances in enzyme regulation 1988;27():43-55.
1988: Anthony E Pegg; B Stanley; A Pajunen; A Crozat; O A Jänne
Properties of human and rodent S-adenosylmethionine decarboxylase.
Advances in experimental medicine and biology 1988;250():101-9.
1988: Anthony E Pegg; K Morimoto; M Eileen Dolan
Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.
Chemico-biological interactions 1988;65(3):275-81.
1987: G J Sertich; L Persson; Anthony E Pegg
Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin.
The American journal of physiology 1987;253(5 Pt 1):C687-92.
1987: D A Scicchitano; Anthony E Pegg
Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals.
Mutation research 1987;192(3):207-10.
1987: T L Byers; R Kameji; D Eugene Rannels; Anthony E Pegg
Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines.
The American journal of physiology 1987;252(6 Pt 1):C663-9.
1987: Anthony E Pegg; R Wechter; A Pajunen
Increase in S-adenosylmethionine decarboxylase in SV-3T3 cells treated with S-methyl-5'-methylthioadenosine.
The Biochemical journal 1987;244(1):49-54.
1987: Anthony E Pegg; D Scicchitano; K Morimoto; M Eileen Dolan
Specificity of O6-alkylguanine-DNA alkyltransferase.
IARC scientific publications 1987;(84):30-4.
1987: Anthony E Pegg; M Eileen Dolan
Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase.
Pharmacology & therapeutics 1987;34(2):167-79.
1986: Anthony E Pegg; R S Wechter; R S Clark; L Wiest; B G Erwin
Acetylation of decarboxylated S-adenosylmethionine by mammalian cells.
Biochemistry 1986;25(2):379-84.
1985: Anthony E Pegg; M Eileen Dolan; D Scicchitano; K Morimoto
Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
Environmental health perspectives 1985;62():109-14.
1985: K Morimoto; M Eileen Dolan; D Scicchitano; Anthony E Pegg
Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli.
Carcinogenesis 1985;6(7):1027-31.
1984: Anthony E Pegg; D Scicchitano; M Eileen Dolan
Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.
Cancer research 1984;44(9):3806-11.
1984: M Eileen Dolan; D Scicchitano; B Singer; Anthony E Pegg
Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
Biochemical and biophysical research communications 1984;123(1):324-30.