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James Peggins

Research Profile

Chemicals & Drugs

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TOP 3
Elena Y Dobrikova; James E Estep; Steven L Giardina; Christian Goetz; Sarah K Lawson; Karen Muszynski; James O Peggins; Karyol Poole; Sheryl Ruppel; Eric M Vela; Robert W Walters; Matthias Gromeier
Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.
Pramod S Terse; Daphne Y Vasconcelos; Denise A Contos; Michael A Hawk; Jerry D Johnson; James O Peggins; Susan P Perrine; Glenn D Ritchie; Michael J Ryan; Joseph E Tomaszewski
Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.
O R Idowu; James O Peggins; R Cullison; J von Bredow
Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin.

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All Publications

2012: Elena Y Dobrikova; James E Estep; Steven L Giardina; Christian Goetz; Sarah K Lawson; Karen Muszynski; James O Peggins; Karyol Poole; Sheryl Ruppel; Eric M Vela; Robert W Walters; Matthias Gromeier
Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.
Journal of virology 2012;86(5):2750-9.
2011: Pramod S Terse; Daphne Y Vasconcelos; Denise A Contos; Michael A Hawk; Jerry D Johnson; James O Peggins; Susan P Perrine; Glenn D Ritchie; Michael J Ryan; Joseph E Tomaszewski
Short-term toxicity study of ST-20 (NSC-741804) by oral gavage in Sprague-Dawley rats.
Toxicologic pathology 2011;39(4):614-22.
2010: O R Idowu; James O Peggins; R Cullison; J von Bredow
Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin.
Research in veterinary science 2010;89(2):230-5.
2009: Malabika Sen; Patricia J Tosca; Christa Zwayer; Michael J Ryan; Jerry D Johnson; Katherine A B Knostman; Patricia C Giclas; James O Peggins; Joseph E Tomaszewski; Timothy P McMurray; Changyou Li; Michael S Leibowitz; Robert L Ferris; William Gooding; Sufi M Thomas; Daniel E Johnson; Jennifer Rubin Grandis
Lack of toxicity of a STAT3 decoy oligonucleotide.
Cancer chemotherapy and pharmacology 2009;63(6):983-95.
2005: David N Heller; James O Peggins; Cristina B Nochetto; Michelle L Smith; O Alberto Chiesa; Keesla Moulton
LC/MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;821(1):22-30.
2004: Robert A Parise; Barney R Sparrow; John W Merrill; Irma M Grossi; Joseph M Covey; James O Peggins; Merrill J Egorin
Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;810(1):35-40.
2004: Olutosin R Idowu; James O Peggins
Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high-performance liquid chromatography with fluorescence detection.
Journal of pharmaceutical and biomedical analysis 2004;35(1):143-53.
2004: Paktiya Teja-Isavadharm; James O Peggins; Thomas G Brewer; Nicholas J White; H Kyle Webster; Dennis E Kyle
Plasmodium falciparum-based bioassay for measurement of artemisinin derivatives in plasma or serum.
Antimicrobial agents and chemotherapy 2004;48(3):954-60.
2003: Pamela L Chamberlain; Bruce A Fowler; Mary Sexton; James O Peggins; Jurgen von Bredow
Preliminary studies of offspring exposure to phenylbutazone and ivermectin during the perinatal period in a Holstein cow-calf model.
Toxicology and applied pharmacology 2003;187(3):198-208.
2002: Sornchai Looareesuwan; Berend Oosterhuis; B M Schilizzi; F A E Sollie; Polrat Wilairatana; Srivicha Krudsood; Ch B Lugt; P A M Peeters; James O Peggins
Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria.
British journal of clinical pharmacology 2002;53(5):492-500.
2000: JM Petras; GD Young; Richard Alexander Bauman; Dennis E Kyle; Montip Gettayacamin; H Kyle Webster; K D Corcoran; James O Peggins; M A Vane; Thomas G Brewer
Arteether-induced brain injury in Macaca mulatta. I. The precerebellar nuclei: the lateral reticular nuclei, paramedian reticular nuclei, and perihypoglossal nuclei.
Anatomy and embryology 2000;201(5):383-97.
1999: QG Li; RP Brueckner; James O Peggins; KM Trotman; Thomas G Brewer
Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses.
European journal of drug metabolism and pharmacokinetics 1999;24(3):213-23.
1998: QG Li; James O Peggins; Ai J Lin; K J Masonic; KM Trotman; Thomas G Brewer
Pharmacology and toxicology of artelinic acid: preclinical investigations on pharmacokinetics, metabolism, protein and red blood cell binding, and acute and anorectic toxicities.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(3):332-40.
1998: JM Grace; A J Aguilar; KM Trotman; James O Peggins; Thomas G Brewer
Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(4):313-7.
1998: QG Li; James O Peggins; L L Fleckenstein; K Masonic; M H Heiffer; Thomas G Brewer
The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats.
The Journal of pharmacy and pharmacology 1998;50(2):173-82.
1998: Raymond F Genovese; DB Newman; Q Li; James O Peggins; Thomas G Brewer
Dose-dependent brainstem neuropathology following repeated arteether administration in rats.
Brain research bulletin 1998;45(2):199-202.
1997: Olutosin R Idowu; Ai J Lin; JM Grace; James O Peggins
Biomimetic metabolism of artelinic acid by chemical cytochrome P-450 model systems.
Pharmaceutical research 1997;14(10):1449-54.
1997: K U Leo; JM Grace; Q Li; James O Peggins; A L Mitchell; T Aguilar; Thomas G Brewer
Effects of Plasmodium berghei infection on arteether metabolism and disposition.
Pharmacology 1997;54(5):276-84.
1997: JM Petras; Dennis E Kyle; Montip Gettayacamin; GD Young; Richard Alexander Bauman; H Kyle Webster; K D Corcoran; James O Peggins; M A Vane; Thomas G Brewer
Arteether: risks of two-week administration in Macaca mulatta.
The American journal of tropical medicine and hygiene 1997;56(4):390-6.
1996: Paktiya Teja-Isavadharm; François Nosten; Dennis E Kyle; Christine Luxemburger; Feiko O ter Kuile; James O Peggins; Thomas G Brewer; N J White
Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay.
British journal of clinical pharmacology 1996;42(5):599-604.
1995: O R Idowu; James O Peggins; Thomas G Brewer
Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(1):18-27.
1995: O R Idowu; James O Peggins; Thomas G Brewer; C Kelley
Metabolism of a candidate 8-aminoquinoline antimalarial agent, WR 238605, by rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(1):1-17.
1994: Thomas G Brewer; Stephen Grate; James O Peggins; P J Weina; JM Petras; B S Levine; M H Heiffer; BG Schuster
Fatal neurotoxicity of arteether and artemether.
The American journal of tropical medicine and hygiene 1994;51(3):251-9.
1994: Thomas G Brewer; James O Peggins; Stephen Grate; JM Petras; B S Levine; P J Weina; J Swearengen; M H Heiffer; BG Schuster
Neurotoxicity in animals due to arteether and artemether.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88 Suppl 1():S33-6.
1994: MT Marino; James O Peggins; L D Brown; M R Urquhart; Thomas G Brewer
Pharmacokinetics and kinetic-dynamic modeling of an 8-aminoquinoline candidate anticyanide and antimalarial drug (WR242511).
Drug metabolism and disposition: the biological fate of chemicals 1994;22(3):358-66.
1993: MT Marino; James O Peggins; Thomas G Brewer
High-performance liquid chromatographic method for the determination of a candidate 8-aminoquinoline antimalarial drug (WR 242511) using oxidative electrochemical detection.
Journal of chromatography 1993;616(2):338-43.
1992: James O Peggins; T F McMahon; Myron Weiner; L Lesko
The effects of age on the pharmacokinetics and biotransformation of theophylline in vivo and in vitro in the Mongolian gerbil (Meriones unguiculatus).
Mechanisms of ageing and development 1992;66(2):173-86.
1992: B J Berger; N A Naiman; James Edwin Hall; James O Peggins; Thomas G Brewer; Richard R Tidwell
Primary and secondary metabolism of pentamidine by rats.
Antimicrobial agents and chemotherapy 1992;36(9):1825-31.
1991: V Melendez; James O Peggins; Thomas G Brewer; A D Theoharides
Determination of the antimalarial arteether and its deethylated metabolite dihydroartemisinin in plasma by high-performance liquid chromatography with reductive electrochemical detection.
Journal of pharmaceutical sciences 1991;80(2):132-8.
1990: T F McMahon; James O Peggins; M M Centra; Myron Weiner
Age-related changes in biotransformation of azoxymethane and methylazoxymethanol in vitro.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(5):501-13.
1987: James O Peggins; T F McMahon; W P Beierschmitt; Myron Weiner
Comparison of hepatic and renal metabolism of acetaminophen in male and female miniature swine.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(2):270-3.