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Marcel Pelhate

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

Amino Acid Sequences

Physiology

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maria elena de lima; Suely G Figueiredo; Adriano M C Pimenta; D M Santos; Márcia H Borges; Marta N Cordeiro; Michael Richardson; Leida Calegário Oliveira; Maria Stankiewicz; Marcel Pelhate
Peptides of arachnid venoms with insecticidal activity targeting sodium channels.
David Strugatsky; Noam Zilberberg; Maria Stankiewicz; Nitza Ilan; Michael Turkov; Lior Cohen; Marcel Pelhate; Nicolas Gilles; Dalia Gordon; Michael Gurevitz
Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58.
Fredy V Coronas; Maria Stankiewicz; Cesar V F Batista; S Giraud; J M Alam; Lourival D Possani; Dietrich Mebs; Marcel Pelhate
Primary structure and electrophysiological characterization of two almost identical isoforms of toxin from Isometrus vittatus (family: Buthidae) scorpion venom.

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All Publications

2007: maria elena de lima; Suely G Figueiredo; Adriano M C Pimenta; D M Santos; Márcia H Borges; Marta N Cordeiro; Michael Richardson; Leida Calegário Oliveira; Maria Stankiewicz; Marcel Pelhate
Peptides of arachnid venoms with insecticidal activity targeting sodium channels.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2007;146(1-2):264-79.
2005: David Strugatsky; Noam Zilberberg; Maria Stankiewicz; Nitza Ilan; Michael Turkov; Lior Cohen; Marcel Pelhate; Nicolas Gilles; Dalia Gordon; Michael Gurevitz
Genetic polymorphism and expression of a highly potent scorpion depressant toxin enable refinement of the effects on insect Na channels and illuminate the key role of Asn-58.
Biochemistry 2005;44(25):9179-87.
2003: Fredy V Coronas; Maria Stankiewicz; Cesar V F Batista; S Giraud; J M Alam; Lourival D Possani; Dietrich Mebs; Marcel Pelhate
Primary structure and electrophysiological characterization of two almost identical isoforms of toxin from Isometrus vittatus (family: Buthidae) scorpion venom.
Toxicon : official journal of the International Society on Toxinology 2003;41(8):989-97.
2003: Chun-Guang Wang; Nicolas Gilles; Alain Hamon; Frédéric Le Gall; Maria Stankiewicz; Marcel Pelhate; Yu-Mei Xiong; Da-Cheng Wang; Cheng-Wu Chi
Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis.
Biochemistry 2003;42(16):4699-708.
2003: Thouraya Mejri; Lamia Borchani; Najet Srairi-Abid; Rym Benkhalifa; Sandrine Cestele; Imed Regaya; Habib Karoui; Marcel Pelhate; Hervé Rochat; Mohamed El Ayeb
BotIT6: a potent depressant insect toxin from Buthus occitanus tunetanus venom.
Toxicon : official journal of the International Society on Toxinology 2003;41(2):163-71.
2003: Chun-Guang Wang; MH Ling; Cheng-Wu Chi; Da-Cheng Wang; Marcel Pelhate
Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch.
The journal of peptide research : official journal of the American Peptide Society 2003;61(1):7-16.
2002: Balkiss Bouhaouala-Zahar; Rym Benkhalifa; Najet Srairi; Ilhem Zenouaki; Caroline Ligny-Lemaire; Pascal Drevet; François Sampieri; Marcel Pelhate; Mohamed El Ayeb; André Ménez; Habib Karoui; Frédéric Ducancel
A chimeric scorpion alpha-toxin displays de novo electrophysiological properties similar to those of alpha-like toxins.
European journal of biochemistry / FEBS 2002;269(12):2831-41.
2002: Maria Stankiewicz; Françoise Grolleau; Ewa Kiełbasiewicz; Izabela Panek; Bruno Lapied; Marcel Pelhate
[Spontaneous activity of neural membranes].
Postȩpy higieny i medycyny doświadczalnej 2002;56(3):255-62.
2001: Françoise Grolleau; Laurence Gamelin; Michèle Boisdron-Celle; Bruno Lapied; Marcel Pelhate; Erick Gamelin
A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels.
Journal of neurophysiology 2001;85(5):2293-7.
2001: Françoise Grolleau; Maria Stankiewicz; Liesl C Birinyi-Strachan; X H Wang; G M Nicholson; Marcel Pelhate; Bruno Lapied
Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.
The Journal of experimental biology 2001;204(Pt 4):711-21.
2000: pierre escoubas; Maria Stankiewicz; T Takaoka; Marcel Pelhate; Régine Romi-Lebrun; FQ Wu; Terumi Nakajima
Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensi.
FEBS letters 2000;483(2-3):175-80.
2000: Gerardo Corzo; pierre escoubas; Maria Stankiewicz; Marcel Pelhate; C P Kristensen; Terumi Nakajima
Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).
European journal of biochemistry / FEBS 2000;267(18):5783-95.
2000: Maria Stankiewicz; Izabela Panek; B Grajpel; E Tegowska; W Kadziela; Marcel Pelhate
[Modification of bioelectric functions in the nervous system as a result of neurotoxin action].
Postȩpy higieny i medycyny doświadczalnej 2000;54(3):371-9.
1999: Maria Stankiewicz; Alain Hamon; Rym Benkhalifa; W Kadziela; Bernard Hue; S Lucas; Dietrich Mebs; Marcel Pelhate
Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptor.
Toxicon : official journal of the International Society on Toxinology 1999;37(10):1431-45.
1999: Bruno Lapied; Maria Stankiewicz; Françoise Grolleau; Hervé Rochat; E Zlotkin; Marcel Pelhate
Biophysical properties of scorpion alpha-toxin-sensitive background sodium channel contributing to the pacemaker activity in insect neurosecretory cells (DUM neurons).
The European journal of neuroscience 1999;11(4):1449-60.
1999: Sandrine Cestèle; Maria Stankiewicz; Pascal Mansuelle; Michel De Waard; Bénédicte Dargent; Nicolas Gilles; Marcel Pelhate; Hervé Rochat; Marie-France Martin-Eauclaire; D Gordon
Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects.
The European journal of neuroscience 1999;11(3):975-85.
1999: Oren Froy; Noam Zilberberg; Dalia Gordon; Michael Turkov; Nicolas Gilles; Maria Stankiewicz; Marcel Pelhate; E Loret; D A Oren; B Shaanan; Michael Gurevitz
The putative bioactive surface of insect-selective scorpion excitatory neurotoxins.
The Journal of biological chemistry 1999;274(9):5769-76.
1999: Isabelle Krimm; Nicolas Gilles; Pierre-Eric Sautière; Maria Stankiewicz; Marcel Pelhate; D Gordon; Jean-Marc Lancelin
NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus.
Journal of molecular biology 1999;285(4):1749-63.
1998: Michael Gurevitz; Oren Froy; Noam Zilberberg; Michael Turkov; David Strugatsky; Edward Gershburg; D Lee; M E Adams; Vitali Tugarinov; Jacob Anglister; B Shaanan; E Loret; Maria Stankiewicz; Marcel Pelhate; Dalia Gordon; Nor Chejanovsky
Sodium channel modifiers from scorpion venom: structure-activity relationship, mode of action and application.
Toxicon : official journal of the International Society on Toxinology 1998;36(11):1671-82.
1998: Marcel Pelhate; Maria Stankiewicz; R Ben Khalifa
[Anti-insect scorpion toxins: historical account, activities and prospects].
Comptes rendus des séances de la Société de biologie et de ses filiales 1998;192(3):463-84.
1997: R Ben Khalifa; Maria Stankiewicz; Marcel Pelhate; S E Serrano-Hernandez; Lourival D Possani; H Hinkel; Dietrich Mebs
Action of babycurus-toxin 1 from the east African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon.
Toxicon : official journal of the International Society on Toxinology 1997;35(7):1069-80.
1997: Michael Turkov; S Rashi; Z Noam; Dalia Gordon; R Ben Khalifa; Maria Stankiewicz; Marcel Pelhate; Michael Gurevitz
In vitro folding and functional analysis of an anti-insect selective scorpion depressant neurotoxin produced in Escherichia coli.
Protein expression and purification 1997;10(1):123-31.
1997: Lamia Borchani; Maria Stankiewicz; Charles Kopeyan; Pascal Mansuelle; Riadh Kharrat; Sandrine Cestèle; Habib Karoui; Hervé Rochat; Marcel Pelhate; Mohamed El Ayeb
Purification, structure and activity of three insect toxins from Buthus occitanus tunetanus venom.
Toxicon : official journal of the International Society on Toxinology 1997;35(3):365-82.
1997: Rym Benkhalifa; Maria Stankiewicz; Bruno Lapied; Michael Turkov; Noam Zilberberg; Michael Gurevitz; Marcel Pelhate
Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker.
Life sciences 1997;61(8):819-30.
1996: I Shichor; Mike Fainzilber; Marcel Pelhate; C O Malecot; E Zlotkin; D Gordon
Interactions of delta-conotoxins with alkaloid neurotoxins reveal differences between the silent and effective binding sites on voltage-sensitive sodium channels.
Journal of neurochemistry 1996;67(6):2451-60.
1996: Lamia Borchani; Pascal Mansuelle; Maria Stankiewicz; F Grolleau; Sandrine Cestèle; Habib Karoui; Bruno Lapied; Hervé Rochat; Marcel Pelhate; Mohamed El Ayeb
A new scorpion venom toxin paralytic to insects that affects Na+ channel activation. Purification, structure, antigenicity and mode of action.
European journal of biochemistry / FEBS 1996;241(2):525-32.
1996: Noam Zilberberg; Dalia Gordon; Marcel Pelhate; M E Adams; T M Norris; E Zlotkin; Michael Gurevitz
Functional expression and genetic alteration of an alpha scorpion neurotoxin.
Biochemistry 1996;35(31):10215-22.
1996: B Bouhaouala-Zahar; Frédéric Ducancel; I Zenouaki; R Ben Khalifa; Lamia Borchani; Marcel Pelhate; Jean-Claude Boulain; Mohamed El Ayeb; A Ménez; Habib Karoui
A recombinant insect-specific alpha-toxin of Buthus occitanus tunetanus scorpion confers protection against homologous mammal toxins.
European journal of biochemistry / FEBS 1996;238(3):653-60.
1996: Dalia Gordon; Marie-France Martin-Eauclaire; Sandrine Cestèle; Charles Kopeyan; E Carlier; R B Khalifa; Marcel Pelhate; Hervé Rochat
Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels.
The Journal of biological chemistry 1996;271(14):8034-45.
1996: Irina T Sinakevitch; M Geffard; Marcel Pelhate; Bruno Lapied
Anatomy and targets of Dorsal Unpaired Median neurones in the Terminal Abdominal Ganglion of the male cockroach Periplaneta americana L.
The Journal of comparative neurology 1996;367(1):147-63.
1996: Maria Stankiewicz; Marcel Pelhate; I Pancerzyńska; A Zienkiewicz; W Kadziela
Effect of K+ accumulation removal and high extracellular osmolarity on K+ current in insect axonal membrane.
Acta neurobiologiae experimentalis 1996;56(1):95-102.
1995: Sandrine Cestèle; R B Ben Khalifa; Marcel Pelhate; Hervé Rochat; Dalia Gordon
Alpha-scorpion toxins binding on rat brain and insect sodium channels reveal divergent allosteric modulations by brevetoxin and veratridine.
The Journal of biological chemistry 1995;270(25):15153-61.
1995: V Dubreil; Bernard Hue; Marcel Pelhate
Outward chloride/potassium co-transport in insect neurosecretory cells (DUM neurones).
Comparative biochemistry and physiology. Part A, Physiology 1995;111(2):263-70.
1994: Mohamed El Ayeb; Lamia Borchani; Riadh Kharrat; Habib Karoui; Marcel Pelhate; Hervé Rochat
[Scorpion toxins: a study model of the structure-function relation of proteins].
Archives de l'Institut Pasteur de Tunis 1994;71(3-4):469-72.
1992: A Duval; C O Malécot; Marcel Pelhate; T Piek
Poneratoxin, a new toxin from an ant venom, reveals an interconversion between two gating modes of the Na channels in frog skeletal muscle fibres.
Pflügers Archiv : European journal of physiology 1992;420(3-4):239-47.
1991: F Tribut; Bruno Lapied; A Duval; Marcel Pelhate
A neosynthesis of sodium channels is involved in the evolution of the sodium current in isolated adult DUM neurons.
Pflügers Archiv : European journal of physiology 1991;419(6):665-7.
1991: Y Adjibadé; Bernard Hue; Marcel Pelhate; Robert Anton
Action of calycanthine on nervous transmission in cockroach central nervous system.
Planta medica 1991;57(2):99-101.
1991: T Piek; A Duval; Bernard Hue; Henk Karst; Bruno Lapied; P Mantel; T Nakajima; Marcel Pelhate; J O Schmidt
Poneratoxin, a novel peptide neurotoxin from the venom of the ant, Paraponera clavata.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;99(3):487-95.
1990: M Eitan; E Fowler; R Herrmann; A Duval; Marcel Pelhate; E Zlotkin
A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure, and mode of action.
Biochemistry 1990;29(25):5941-7.
1990: T Piek; Bernard Hue; P Mantel; T Nakajima; Marcel Pelhate; T Yasuhara
Threonine6-bradykinin in the venom of the wasp Colpa interrupta (F.) presynaptically blocks nicotinic synaptic transmission in the insect CNS.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1990;96(1):157-62.
1989: A Duval; C O Malécot; Marcel Pelhate; H Rochat
Changes in Na channel properties of frog and rat skeletal muscles induced by the AaH II toxin from the scorpion Androctonus australis.
Pflügers Archiv : European journal of physiology 1989;415(3):361-71.
1989: Marcel Pelhate; C O Malécot
Structure-activity relationships of aminopyridines and derivates on axonal K+ conductance.
Pflügers Archiv : European journal of physiology 1989;414 Suppl 1():S140-1.
1988: M E de Lima; F Couraud; Bruno Lapied; Marcel Pelhate; C Ribeiro Diniz; Hervé Rochat
Photoaffinity labeling of scorpion toxin receptors associated with insect synaptosomal Na+ channels.
Biochemical and biophysical research communications 1988;151(1):187-92.
1987: T Piek; Bernard Hue; L Mony; T Nakajima; Marcel Pelhate; T Yasuhara
Block of synaptic transmission in insect CNS by toxins from the venom of the wasp Megascolia flavifrons (Fab.).
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1987;87(2):287-95.
1987: T Piek; Bernard Hue; Marcel Pelhate; L Mony
The venom of the wasp Campsomeris sexmaculata (F.) blocks synaptic transmission in insect CNS.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1987;87(2):283-6.
1985: E Zlotkin; D Kadouri; D Gordon; Marcel Pelhate; M F Martin; H Rochat
An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site.
Archives of biochemistry and biophysics 1985;240(2):877-87.
1984: Marcel Pelhate; J Laufer; Yves François Pichon; E Zlotkin
Effects of several sea anemone and scorpion toxins on excitability and ionic currents in the giant axon of the cockroach.
Journal de physiologie 1984;79(4):309-17.
1984: Yves François Pichon; Marcel Pelhate
Effect of toxin 1 from Androctonus australis Hector on sodium currents in giant axons of Loligo forbesi.
Journal de physiologie 1984;79(4):318-26.
1982: P Lazarovici; P Yanai; Marcel Pelhate; E Zlotkin
Insect toxic component from the venom of a chactoid scorpion, Scorpio maurus palmatus (Scorpionidae).
The Journal of biological chemistry 1982;257(14):8397-404.
1982: Marcel Pelhate; E Zlotkin
Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana).
The Journal of experimental biology 1982;97():67-77.
1982: E Zlotkin; D Lester; P Lazarovici; Marcel Pelhate
The chemistry and axonal action of two insect toxins derived from the venom of the scorpion buthotus judaicus.
Toxicon : official journal of the International Society on Toxinology 1982;20(1):323-31.
1981: Bernard Hue; Marcel Pelhate; J Chanelet
[Action of piribedil on synaptic transmission in the cockroach central nervous system (Periplaneta americana L.) (author's transl)].
Journal de pharmacologie 1981;12(4):455-63.
1980: I D Harrow; Bernard Hue; Marcel Pelhate; David B Sattelle
Cockroach giant interneurones stained by cobalt-backfilling of dissected axons.
The Journal of experimental biology 1980;84():341-3.