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Pier Giuseppe Pelicci

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Disorders

Leukemia, Promyelocytic, Acute

Living Beings

Mice

Physiology

Concepts & Ideas

Molecular Sequence Data

Anatomy

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Publications

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Cicalese Angelo; Bonizzi Giuseppina; Pasi Cristina E; Faretta Mario; Ronzoni Simona; Giulini Barbara; Brisken Cathrin; Minucci Saverio; Di Fiore Pier Paolo; Pelicci Pier Giuseppe
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.
Gargiulo Gaetano; Levy Samuel; Bucci Gabriele; Romanenghi Mauro; Fornasari Lorenzo; Beeson Karen Y; Goldberg Susanne M; Cesaroni Matteo; Ballarini Marco; Santoro Fabio; Bezman Natalie; Frigè Gianmaria; Gregory Philip D; Holmes Michael C; Strausberg Robert L; Pelicci Pier Giuseppe; Urnov Fyodor D; Minucci Saverio
NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation.
Rocca A; Minucci S; Tosti G; Croci D; Contegno F; Ballarini M; Nolè F; Munzone E; Salmaggi A; Goldhirsch A; Pelicci P G; Testori A
A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma.

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All Publications

2009: Cicalese Angelo; Bonizzi Giuseppina; Pasi Cristina E; Faretta Mario; Ronzoni Simona; Giulini Barbara; Brisken Cathrin; Minucci Saverio; Di Fiore Pier Paolo; Pelicci Pier Giuseppe
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.
Cell 2009;138(6):1083-95.
2009: Gargiulo Gaetano; Levy Samuel; Bucci Gabriele; Romanenghi Mauro; Fornasari Lorenzo; Beeson Karen Y; Goldberg Susanne M; Cesaroni Matteo; Ballarini Marco; Santoro Fabio; Bezman Natalie; Frigè Gianmaria; Gregory Philip D; Holmes Michael C; Strausberg Robert L; Pelicci Pier Giuseppe; Urnov Fyodor D; Minucci Saverio
NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation.
Developmental cell 2009;16(3):466-81.
2009: Rocca A; Minucci S; Tosti G; Croci D; Contegno F; Ballarini M; Nolè F; Munzone E; Salmaggi A; Goldhirsch A; Pelicci P G; Testori A
A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma.
British journal of cancer 2009;100(1):28-36.
2009: Viale Andrea; De Franco Francesca; Orleth Annette; Cambiaghi Valeria; Giuliani Virginia; Bossi Daniela; Ronchini Chiara; Ronzoni Simona; Muradore Ivan; Monestiroli Silvia; Gobbi Alberto; Alcalay Myriam; Minucci Saverio; Pelicci Pier Giuseppe
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature 2009;457(7225):51-6.
2008: Cesaroni Matteo; Cittaro Davide; Brozzi Alessandro; Pelicci Pier Giuseppe; Luzi Lucilla
CARPET: a web-based package for the analysis of ChIP-chip and expression tiling data.
Bioinformatics (Oxford, England) 2008;24(24):2918-20.
2008: Gardini Alessandro; Cesaroni Matteo; Luzi Lucilla; Okumura Akiko J; Biggs Joseph R; Minardi Simone P; Venturini Elisa; Zhang Dong-Er; Pelicci Pier Giuseppe; Alcalay Myriam
AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets.
PLoS genetics 2008;4(11):e1000275.
2008: Di Micco Raffaella; Cicalese Angelo; Fumagalli Marzia; Dobreva Miryana; Verrecchia Alessandro; Pelicci Pier Giuseppe; di Fagagna Fabrizio d'Adda
DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization.
Cell cycle (Georgetown, Tex.) 2008;7(22):3601-6.
2008: Martin-Padura Ines; de Nigris Filomena; Migliaccio Enrica; Mansueto Gelsomina; Minardi Simone; Rienzo Monica; Lerman Lilach O; Stendardo Massimo; Giorgio Marco; De Rosa Gaetano; Pelicci Pier Giuseppe; Napoli Claudio
p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.
Endothelium : journal of endothelial cell research 2008;15(5-6):276-87.
2008: Tapinassi Cinzia; Gerbino Elvira; Malazzi Omar; Micucci Carla; Gasparini Patrizia; Najera Maria J; Calasanz Maria J; Odero Maria D; Pelicci Pier Giuseppe; Belloni Elena
A new dic(7;12)(p12.21;p12.2) chromosome aberration in a case of acute myeloid leukemia.
Cancer genetics and cytogenetics 2008;185(2):102-5.
2008: Bonetti Paola; Davoli Teresa; Sironi Cristina; Amati Bruno; Pelicci Pier Giuseppe; Colombo Emanuela
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.
The Journal of cell biology 2008;182(1):19-26.
2008: Lo-Coco Francesco; Cuneo Antonio; Pane Fabrizio; Cilloni Daniela; Diverio Daniela; Mancini Marco; Testoni Nicoletta; Bardi Antonella; Izzo Barbara; Bolli Niccolò; La Starza Roberta; Fazi Paola; Iacobelli Simona; Piciocchi Alfonso; Vignetti Marco; Amadori Sergio; Mandelli Franco; Pelicci Pier Giuseppe; Mecucci Cristina; Falini Brunangelo; Saglio Giuseppe;
Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia.
Haematologica 2008;93(7):1017-24.
2008: Finetti Francesca; Pellegrini Michela; Ulivieri Cristina; Savino Maria Teresa; Paccagnini Eugenio; Ginanneschi Chiara; Lanfrancone Luisa; Pelicci Pier Giuseppe; Baldari Cosima T
The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity.
Blood 2008;111(10):5017-27.
2008: Cosentino Francesco; Francia Pietro; Camici Giovanni G; Pelicci Pier Giuseppe; Lüscher Thomas F; Volpe Massimo
Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(4):622-8.
2008: Berry A; Greco A; Giorgio M; Pelicci P G; de Kloet R; Alleva E; Minghetti L; Cirulli F
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Experimental gerontology 2008;43(3):200-8.
2008: Gorello P; La Starza R; Brandimarte L; Trisolini S M; Pierini V; Crescenzi B; Limongi M Z; Nanni M; Belloni E; Tapinassi C; Gerbino E; Martelli M F; Foà R; Meloni G; Pelicci P G; Mecucci C
A PDGFRB-positive acute myeloid malignancy with a new t(5;12)(q33;p13.3) involving the ERC1 gene.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(1):216-8.
2008: Fanelli M; Caprodossi S; Ricci-Vitiani L; Porcellini A; Tomassoni-Ardori F; Amatori S; Andreoni F; Magnani M; De Maria R; Santoni A; Minucci S; Pelicci P G
Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
Oncogene 2008;27(3):358-65.
2007: Shing Danielle C; Trubia Maurizio; Marchesi Francesco; Radaelli Enrico; Belloni Elena; Tapinassi Cinzia; Scanziani Eugenio; Mecucci Cristina; Crescenzi Barbara; Lahortiga Idoya; Odero Maria D; Zardo Giuseppe; Gruszka Alicja; Minucci Saverio; Di Fiore Pier Paolo; Pelicci Pier Giuseppe
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice.
The Journal of clinical investigation 2007;117(12):3696-707.
2007: Zaccagnini Germana; Martelli Fabio; Magenta Alessandra; Cencioni Chiara; Fasanaro Pasquale; Nicoletti Carmine; Biglioli Paolo; Pelicci Pier Giuseppe; Capogrossi Maurizio C
p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia.
The Journal of biological chemistry 2007;282(43):31453-9.
2007: Giorgio Marco; Trinei Mirella; Migliaccio Enrica; Pelicci Pier Giuseppe
Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
Nature reviews. Molecular cell biology 2007;8(9):722-8.
2007: Menini S; Iacobini C; Ricci C; Oddi G; Pesce C; Pugliese F; Block K; Abboud H E; Giorgio M; Migliaccio E; Pelicci P G; Pugliese G
Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.
Diabetologia 2007;50(9):1997-2007.
2007: Patrussi Laura; Ulivieri Cristina; Lucherini Orso Maria; Paccani Silvia Rossi; Gamberucci Alessandra; Lanfrancone Luisa; Pelicci Pier Giuseppe; Baldari Cosima T
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
Blood 2007;110(6):1730-8.
2007: Minucci Saverio; Pelicci Pier Giuseppe
Determinants of oncogenic transformation in acute promyelocytic leukemia: the hetero-union makes the force.
Cancer cell 2007;12(1):1-3.
2007: Villa Raffaella; Pasini Diego; Gutierrez Arantxa; Morey Lluis; Occhionorelli Manuela; Viré Emmanuelle; Nomdedeu Josep F; Jenuwein Thomas; Pelicci Pier Giuseppe; Minucci Saverio; Fuks Francois; Helin Kristian; Di Croce Luciano
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.
Cancer cell 2007;11(6):513-25.
2007: Zanardi Andrea; Giorgetti Luca; Botrugno Oronza A; Minucci Saverio; Milani Paolo; Pelicci Pier Giuseppe; Carbone Roberta
Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells.
Molecular & cellular proteomics : MCP 2007;6(5):939-47.
2007: Fazi Francesco; Zardo Giuseppe; Gelmetti Vania; Travaglini Lorena; Ciolfi Alberto; Di Croce Luciano; Rosa Alessandro; Bozzoni Irene; Grignani Francesco; Lo-Coco Francesco; Pelicci Pier Giuseppe; Nervi Clara
Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.
Blood 2007;109(10):4432-40.
2007: Carraro Fabio; Pucci Annalisa; Pellegrini Michela; Pelicci Pier Giuseppe; Baldari Cosima T; Naldini Antonella
p66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells.
Journal of cellular physiology 2007;211(2):439-47.
2007: Franceschi Claudio; Bezrukov Vladyslav; Blanché Hélène; Bolund Lars; Christensen Kaare; de Benedictis Giovanna; Deiana Luca; Gonos Efsthatios; Hervonen Antti; Yang Huanning; Jeune Bernard; Kirkwood Tom B L; Kristensen Peter; Leon Alberta; Pelicci Pier Giuseppe; Peltonen Leena; Poulain Michel; Rea Irene Maeve; Remacle José; Robine Jean Marie; Schreiber Stefan; Sikora Ewa; Slagboom Pieternella Eline; Spazzafumo Liana; Stazi Maria Antonietta; Toussaint Olivier; Vaupel James W
Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).
Annals of the New York Academy of Sciences 2007;1100():21-45.
2007: Fagiani Ernesta; Giardina Giuseppina; Luzi Lucilla; Cesaroni Matteo; Quarto Micaela; Capra Maria; Germano Giovanni; Bono Maria; Capillo Manuela; Pelicci PierGiuseppe; Lanfrancone Luisa
RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
Cancer research 2007;67(7):3064-73.
2007: Carbone Roberta; Giorgetti Luca; Zanardi Andrea; Marangi Ida; Chierici Elisabetta; Bongiorno Gero; Fiorentini Francesca; Faretta Mario; Piseri Paolo; Pelicci Pier Giuseppe; Milani Paolo
Retroviral microarray-based platform on nanostructured TiO2 for functional genomics and drug discovery.
Biomaterials 2007;28(13):2244-53.
2007: Marinelli A; Bossi D; Pelicci P G; Minucci S
A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(4):647-50.
2007: Camici Giovanni G; Schiavoni Marzia; Francia Pietro; Bachschmid Markus; Martin-Padura Ines; Hersberger Martin; Tanner Felix C; Pelicci Piergiuseppe; Volpe Massimo; Anversa Piero; Lüscher Thomas F; Cosentino Francesco
Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5217-22.
2007: Pinton Paolo; Rimessi Alessandro; Marchi Saverio; Orsini Francesca; Migliaccio Enrica; Giorgio Marco; Contursi Cristina; Minucci Saverio; Mantovani Fiamma; Wieckowski Mariusz R; Del Sal Giannino; Pelicci Pier Giuseppe; Rizzuto Rosario
Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.
Science (New York, N.Y.) 2007;315(5812):659-63.
2007: Pellegrini M; Finetti F; Petronilli V; Ulivieri C; Giusti F; Lupetti P; Giorgio M; Pelicci P G; Bernardi P; Baldari C T
p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis.
Cell death and differentiation 2007;14(2):338-47.
2007: Berry Alessandra; Capone Francesca; Giorgio Marco; Pelicci Pier Giuseppe; de Kloet E R; Alleva Enrico; Minghetti Luisa; Cirulli Francesca
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.
Experimental gerontology 2007;42(1-2):37-45.
2006: Di Micco Raffaella; Fumagalli Marzia; Cicalese Angelo; Piccinin Sara; Gasparini Patrizia; Luise Chiara; Schurra Catherine; Garre' Massimiliano; Nuciforo Paolo Giovanni; Bensimon Aaron; Maestro Roberta; Pelicci Pier Giuseppe; d'Adda di Fagagna Fabrizio
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.
Nature 2006;444(7119):638-42.
2006: Orsini Francesca; Moroni Maurizio; Contursi Cristina; Yano Masato; Pelicci PierGiuseppe; Giorgio Marco; Migliaccio Enrica
Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.
Biological chemistry 2006;387(10-11):1405-10.
2006: Pezzicoli Alfredo; Ulivieri Cristina; Capitani Nagaja; Ventura Andrea; Pelicci Piergiuseppe; Baldari Cosima T
Expression in T-cells of the proapoptotic protein p66SHC is controlled by promoter demethylation.
Biochemical and biophysical research communications 2006;349(1):322-8.
2006: Marchesi F; Minucci S; Pelicci P G; Gobbi A; Scanziani E
Immunohistochemical detection of Ym1/Ym2 chitinase-like lectins associated with hyalinosis and polypoid adenomas of the transitional epithelium in a mouse with acute myeloid leukemia.
Veterinary pathology 2006;43(5):773-6.
2006: Cimino Giuseppe; Lo-Coco Francesco; Fenu Susanna; Travaglini Lorena; Finolezzi Erica; Mancini Marco; Nanni Mauro; Careddu Angela; Fazi Francesco; Padula Fabrizio; Fiorini Roberto; Spiriti Maria Antonietta Aloe; Petti Maria Concetta; Venditti Adriano; Amadori Sergio; Mandelli Franco; Pelicci Pier Giuseppe; Nervi Clara
Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia.
Cancer research 2006;66(17):8903-11.
2006: Falini Brunangelo; Martelli Maria Paola; Bolli Niccolò; Bonasso Rossella; Ghia Emanuela; Pallotta Maria Teresa; Diverio Daniela; Nicoletti Ildo; Pacini Roberta; Tabarrini Alessia; Galletti Barbara Verducci; Mannucci Roberta; Roti Giovanni; Rosati Roberto; Specchia Giorgina; Liso Arcangelo; Tiacci Enrico; Alcalay Myriam; Luzi Lucilla; Volorio Sara; Bernard Loris; Guarini Anna; Amadori Sergio; Mandelli Franco; Pane Fabrizio; Lo-Coco Francesco; Saglio Giuseppe; Pelicci Pier-Giuseppe; Martelli Massimo F; Mecucci Cristina
Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.
Blood 2006;108(6):1999-2005.
2006: Rota Marcello; LeCapitaine Nicole; Hosoda Toru; Boni Alessandro; De Angelis Antonella; Padin-Iruegas Maria Elena; Esposito Grazia; Vitale Serena; Urbanek Konrad; Casarsa Claudia; Giorgio Marco; Lüscher Thomas F; Pelicci Pier Giuseppe; Anversa Piero; Leri Annarosa; Kajstura Jan
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Circulation research 2006;99(1):42-52.
2006: Mariano A R; Colombo E; Luzi L; Martinelli P; Volorio S; Bernard L; Meani N; Bergomas R; Alcalay M; Pelicci P G
Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.
Oncogene 2006;25(31):4376-80.
2006: Menini Stefano; Amadio Lorena; Oddi Giovanna; Ricci Carlo; Pesce Carlo; Pugliese Francesco; Giorgio Marco; Migliaccio Enrica; Pelicci PierGiuseppe; Iacobini Carla; Pugliese Giuseppe
Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.
Diabetes 2006;55(6):1642-50.
2006: Carbone Roberta; Marangi Ida; Zanardi Andrea; Giorgetti Luca; Chierici Elisabetta; Berlanda Giuseppe; Podestà Alessandro; Fiorentini Francesca; Bongiorno Gero; Piseri Paolo; Pelicci Pier Giuseppe; Milani Paolo
Biocompatibility of cluster-assembled nanostructured TiO2 with primary and cancer cells.
Biomaterials 2006;27(17):3221-9.
2006: Trinei Mirella; Berniakovich Ina; Pelicci Pier Giuseppe; Giorgio Marco
Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66(Shc).
Biochimica et biophysica acta 2006;1757(5-6):624-30.
2006: Migliaccio Enrica; Giorgio Marco; Pelicci Pier Giuseppe
Apoptosis and aging: role of p66Shc redox protein.
Antioxidants & redox signaling 2006;8(3-4):600-8.
2006: Colombo Emanuela; Martinelli Paola; Zamponi Raffaella; Shing Danielle C; Bonetti Paola; Luzi Lucilla; Volorio Sara; Bernard Loris; Pruneri Giancarlo; Alcalay Myriam; Pelicci Pier Giuseppe
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.
Cancer research 2006;66(6):3044-50.
2006: Carbone Roberta; Botrugno Oronza A; Ronzoni Simona; Insinga Alessandra; Di Croce Luciano; Pelicci Pier Giuseppe; Minucci Saverio
Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.
Molecular and cellular biology 2006;26(4):1288-96.
2006: Falini B; Bigerna B; Pucciarini A; Tiacci E; Mecucci C; Morris S W; Bolli N; Rosati R; Hanissian S; Ma Z; Sun Y; Colombo E; Arber D A; Pacini R; La Starza R; Verducci Galletti B; Liso A; Martelli M P; Diverio D; Pelicci P-G; Lo Coco F; Martelli M F
Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5): a comparison with NPMc+ AML.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(2):368-71.
2006: Trubia M; Albano F; Cavazzini F; Cambrin G R; Quarta G; Fabbiano F; Ciambelli F; Magro D; Hernandezo J M; Mancini M; Diverio D; Pelicci P G; Coco F L; Mecucci C; Specchia G; Rocchi M; Liso V; Castoldi G; Cuneo A
Characterization of a recurrent translocation t(2;3)(p15-22;q26) occurring in acute myeloid leukaemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(1):48-54.
2006: Villa Raffaella; Morey Lluis; Raker Veronica A; Buschbeck Marcus; Gutierrez Arantxa; De Santis Francesca; Corsaro Massimo; Varas Florencio; Bossi Daniela; Minucci Saverio; Pelicci Pier Giuseppe; Di Croce Luciano
The methyl-CpG binding protein MBD1 is required for PML-RARalpha function.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1400-5.
2006: Minucci Saverio; Pelicci Pier Giuseppe
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.
Nature reviews. Cancer 2006;6(1):38-51.
2005: Gorletta Tatiana Alessandra; Gasparini Patrizia; D'Elios Mario Milco; Trubia Maurizio; Pelicci Pier Giuseppe; Di Fiore Pier Paolo
Frequent loss of heterozygosity without loss of genetic material in acute myeloid leukemia with a normal karyotype.
Genes, chromosomes & cancer 2005;44(3):334-7.
2005: Colombo Emanuela; Bonetti Paola; Lazzerini Denchi Eros; Martinelli Paola; Zamponi Raffaella; Marine Jean-Christophe; Helin Kristian; Falini Brunangelo; Pelicci Pier Giuseppe
Nucleophosmin is required for DNA integrity and p19Arf protein stability.
Molecular and cellular biology 2005;25(20):8874-86.
2005: Doumont Gilles; Martoriati Alain; Beekman Chantal; Bogaerts Sven; Mee Patrick J; Bureau Fabrice; Colombo Emanuela; Alcalay Myriam; Bellefroid Eric; Marchesi Francesco; Scanziani Eugenio; Pelicci Pier Giuseppe; Marine Jean-Christophe
G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.
The EMBO journal 2005;24(17):3093-103.
2005: Graiani Gallia; Lagrasta Costanza; Migliaccio Enrica; Spillmann Frank; Meloni Marco; Madeddu Paolo; Quaini Federico; Padura Ines Martin; Lanfrancone Luisa; Pelicci PierGiuseppe; Emanueli Costanza
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.
Hypertension 2005;46(2):433-40.
2005: Alcalay Myriam; Tiacci Enrico; Bergomas Roberta; Bigerna Barbara; Venturini Elisa; Minardi Simone P; Meani Natalia; Diverio Daniela; Bernard Loris; Tizzoni Laura; Volorio Sara; Luzi Lucilla; Colombo Emanuela; Lo Coco Francesco; Mecucci Cristina; Falini Brunangelo; Pelicci Pier Giuseppe
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.
Blood 2005;106(3):899-902.
2005: Giorgio Marco; Migliaccio Enrica; Orsini Francesca; Paolucci Demis; Moroni Maurizio; Contursi Cristina; Pelliccia Giovanni; Luzi Lucilla; Minucci Saverio; Marcaccio Massimo; Pinton Paolo; Rizzuto Rosario; Bernardi Paolo; Paolucci Francesco; Pelicci Pier Giuseppe
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.
Cell 2005;122(2):221-33.
2005: Caprodossi Sara; Pedinotti Marika; Amantini Consuelo; Santoni Giorgio; Minucci Saverio; Pelicci Pier Giuseppe; Fanelli Mirco
Differentiation response of acute promyelocytic leukemia cells and PML/RARa leukemogenic activity studies by real-time RT-PCR.
Molecular biotechnology 2005;30(3):231-8.
2005: Ronzoni Simona; Faretta Mario; Ballarini Marco; Pelicci Piergiuseppe; Minucci Saverio
New method to detect histone acetylation levels by flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;66(1):52-61.
2005: Pilatrino Chiara; Cilloni Daniela; Messa Emanuela; Morotti Alessandro; Giugliano Emilia; Pautasso Marisa; Familiari Ubaldo; Cappia Susanna; Pelicci Pier Giuseppe; Lo Coco Francesco; Saglio Giuseppe; Guerrasio Angelo
Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid.
Cancer 2005;104(1):101-9.
2005: Insinga Alessandra; Minucci Saverio; Pelicci Pier Giuseppe
Mechanisms of selective anticancer action of histone deacetylase inhibitors.
Cell cycle (Georgetown, Tex.) 2005;4(6):741-3.
2005: Meani Natalia; Minardi Simone; Licciulli Silvia; Gelmetti Vania; Coco Francesco Lo; Nervi Clara; Pelicci Pier Giuseppe; Müller Heiko; Alcalay Myriam
Molecular signature of retinoic acid treatment in acute promyelocytic leukemia.
Oncogene 2005;24(20):3358-68.
2005: Fazi Francesco; Travaglini Lorena; Carotti Daniela; Palitti Franco; Diverio Daniela; Alcalay Myriam; McNamara Suzan; Miller Wilson H; Lo Coco Francesco; Pelicci Pier Giuseppe; Nervi Clara
Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.
Oncogene 2005;24(11):1820-30.
2005: Patrussi Laura; Savino Maria Teresa; Pellegrini Michela; Paccani Silvia Rossi; Migliaccio Enrica; Plyte Simon; Lanfrancone Luisa; Pelicci Pier Giuseppe; Baldari Cosima T
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Oncogene 2005;24(13):2218-28.
2005: Belloni Elena; Trubia Maurizio; Gasparini Patrizia; Micucci Carla; Tapinassi Cinzia; Confalonieri Stefano; Nuciforo Paolo; Martino Bruno; Lo-Coco Francesco; Pelicci Pier Giuseppe; Di Fiore Pier Paolo
8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes.
Genes, chromosomes & cancer 2005;42(3):320-5.
2005: Kindle Karin B; Troke Philip J F; Collins Hilary M; Matsuda Sachiko; Bossi Daniela; Bellodi Cristian; Kalkhoven Eric; Salomoni Paolo; Pelicci Pier Giuseppe; Minucci Saverio; Heery David M
MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function.
Molecular and cellular biology 2005;25(3):988-1002.
2005: Martoriati Alain; Doumont Gilles; Alcalay Myriam; Bellefroid Eric; Pelicci Pier Giuseppe; Marine Jean-Christophe
dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.
Oncogene 2005;24(8):1461-6.
2005: Falini Brunangelo; Mecucci Cristina; Tiacci Enrico; Alcalay Myriam; Rosati Roberto; Pasqualucci Laura; La Starza Roberta; Diverio Daniela; Colombo Emanuela; Santucci Antonella; Bigerna Barbara; Pacini Roberta; Pucciarini Alessandra; Liso Arcangelo; Vignetti Marco; Fazi Paola; Meani Natalia; Pettirossi Valentina; Saglio Giuseppe; Mandelli Franco; Lo-Coco Francesco; Pelicci Pier-Giuseppe; Martelli Massimo F;
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
The New England journal of medicine 2005;352(3):254-66.
2005: Insinga Alessandra; Monestiroli Silvia; Ronzoni Simona; Gelmetti Vania; Marchesi Francesco; Viale Andrea; Altucci Lucia; Nervi Clara; Minucci Saverio; Pelicci Pier Giuseppe
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway.
Nature medicine 2005;11(1):71-6.
2005: Brenner Carmen; Deplus Rachel; Didelot Céline; Loriot Axelle; Viré Emmanuelle; De Smet Charles; Gutierrez Arantxa; Danovi Davide; Bernard David; Boon Thierry; Pelicci Pier Giuseppe; Amati Bruno; Kouzarides Tony; de Launoit Yvan; Di Croce Luciano; Fuks François
Myc represses transcription through recruitment of DNA methyltransferase corepressor.
The EMBO journal 2005;24(2):336-46.
2005: Insinga Alessandra; Pelicci Pier Giuseppe; Inucci Saverio
Leukemia-associated fusion proteins. Multiple mechanisms of action to drive cell transformation.
Cell cycle (Georgetown, Tex.) 2005;4(1):67-9.
2005: Caprodossi Sara; Galluzzi Luca; Biagetti Simona; Della Chiara Giulia; Pelicci Pier Giuseppe; Magnani Mauro; Fanelli Mirco
In vitro inhibition of promyelocytic leukemia/retinoic acid receptor-alpha (PML/RARalpha) expression and leukemogenic activity by DNA/LNA chimeric antisense oligos.
Oncology research 2005;16(3):157-66.
2004: Francia Pietro; delli Gatti Chiara; Bachschmid Markus; Martin-Padura Ines; Savoia Carmine; Migliaccio Enrica; Pelicci Pier Giuseppe; Schiavoni Marzia; Lüscher Thomas Felix; Volpe Massimo; Cosentino Francesco
Deletion of p66shc gene protects against age-related endothelial dysfunction.
Circulation 2004;110(18):2889-95.
2004: Belloni Elena; Trubia Maurizio; Mancini Marco; Derme Valentina; Nanni Mauro; Lahortiga Idoya; Riccioni Roberta; Confalonieri Stefano; Lo-Coco Francesco; Di Fiore Pier Paolo; Pelicci Pier Giuseppe
A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia.
Genes, chromosomes & cancer 2004;41(3):272-7.
2004: Troglio Flavia; Echart Cinara; Gobbi Alberto; Pawson Tony; Pelicci Pier Giuseppe; De Simoni Maria Grazia; Pelicci Giuliana
The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15476-81.
2004: Danovi Davide; Meulmeester Erik; Pasini Diego; Migliorini Domenico; Capra Maria; Frenk Ruth; de Graaf Petra; Francoz Sarah; Gasparini Patrizia; Gobbi Alberto; Helin Kristian; Pelicci Pier Giuseppe; Jochemsen Aart G; Marine Jean-Christophe
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.
Molecular and cellular biology 2004;24(13):5835-43.
2004: Transidico Pietro; Bianchi Marco; Capra Maria; Pelicci Pier Giuseppe; Faretta Mario
From cells to tissues: fluorescence confocal microscopy in the study of histological samples.
Microscopy research and technique 2004;64(2):89-95.
2004: Zaccagnini Germana; Martelli Fabio; Fasanaro Pasquale; Magenta Alessandra; Gaetano Carlo; Di Carlo Anna; Biglioli Paolo; Giorgio Marco; Martin-Padura Ines; Pelicci Pier Giuseppe; Capogrossi Maurizio C
p66ShcA modulates tissue response to hindlimb ischemia.
Circulation 2004;109(23):2917-23.
2004: Orsini Francesca; Migliaccio Enrica; Moroni Maurizio; Contursi Cristina; Raker Veronica A; Piccini Daniele; Martin-Padura Ines; Pelliccia Giovanni; Trinei Mirella; Bono Maria; Puri Claudia; Tacchetti Carlo; Ferrini Monica; Mannucci Roberta; Nicoletti Ildo; Lanfrancone Luisa; Giorgio Marco; Pelicci Pier Giuseppe
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
The Journal of biological chemistry 2004;279(24):25689-95.
2004: Insinga Alessandra; Monestiroli Silvia; Ronzoni Simona; Carbone Roberta; Pearson Mark; Pruneri Giancarlo; Viale Giuseppe; Appella Ettore; Pelicci PierGiuseppe; Minucci Saverio
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.
The EMBO journal 2004;23(5):1144-54.
2004: Pacini Sonia; Pellegrini Michela; Migliaccio Enrica; Patrussi Laura; Ulivieri Cristina; Ventura Andrea; Carraro Fabio; Naldini Antonella; Lanfrancone Luisa; Pelicci Piergiuseppe; Baldari Cosima T
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
Molecular and cellular biology 2004;24(4):1747-57.
2004: Fanelli Mirco; Fantozzi Anna; De Luca Pasquale; Caprodossi Sara; Matsuzawa Shu-ichi; Lazar Mitchell A; Pelicci Pier Giuseppe; Minucci Saverio
The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.
The Journal of biological chemistry 2004;279(7):5374-9.
2004: Lahortiga Idoya; Agirre Xabier; Belloni Elena; Vázquez Iria; Larrayoz María J; Gasparini Patrizia; Lo Coco Francesco; Pelicci Pier Giuseppe; Calasanz María J; Odero María D
Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells.
Oncogene 2004;23(1):311-6.
2004: Pelicci Pier Giuseppe
Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
The Journal of clinical investigation 2004;113(1):4-7.
2004: Ventura Andrea; Maccarana Marco; Raker Veronica A; Pelicci Pier Giuseppe
A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria.
The Journal of biological chemistry 2004;279(3):2299-306.
2003: Alcalay Myriam; Meani Natalia; Gelmetti Vania; Fantozzi Anna; Fagioli Marta; Orleth Annette; Riganelli Daniela; Sebastiani Carla; Cappelli Enrico; Casciari Cristina; Sciurpi Maria Teresa; Mariano Angela Rosa; Minardi Simone Paolo; Luzi Lucilla; Muller Heiko; Di Fiore Pier Paolo; Frosina Guido; Pelicci Pier Giuseppe
Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.
The Journal of clinical investigation 2003;112(11):1751-61.
2003: Segalla Simona; Rinaldi Laura; Kilstrup-Nielsen Charlotte; Badaracco Gianfranco; Minucci Saverio; Pelicci Pier Giuseppe; Landsberger Nicoletta
Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.
Molecular and cellular biology 2003;23(23):8795-808.
2003: Bruno Silvia; Ghiotto Fabio; Fais Franco; Fagioli Marta; Luzi Lucilla; Pelicci Pier Giuseppe; Grossi Carlo Enrico; Ciccone Ermanno
The PML gene is not involved in the regulation of MHC class I expression in human cell lines.
Blood 2003;101(9):3514-9.
2003: Masseroli M; Cerveri P; Pelicci P G; Alcalay M
GAAS: gene array analyzer software for management, analysis and visualization of gene expression data.
Bioinformatics (Oxford, England) 2003;19(6):774-5.
2003: La Starza Roberta; Trubia Maurizio; Crescenzi Barbara; Matteucci Caterina; Negrini Massimo; Martelli Massimo F; Pelicci Pier Giuseppe; Mecucci Cristina
Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13).
Genes, chromosomes & cancer 2003;36(4):420-3.
2003: Marchesi F; Monestiroli S V; Capillo M; Gobbi A; Minucci S; Pelicci P G; Scanziani E
Eosinophilic crystals as a distinctive morphologic feature of a hyaline droplet nephropathy in a mouse model of acute myelogenous leukaemia.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 2003;50(2):103-7.
2003: Napoli Claudio; Martin-Padura Ines; de Nigris Filomena; Giorgio Marco; Mansueto Gelsomina; Somma Pasquale; Condorelli Mario; Sica Giacomo; De Rosa Gaetano; Pelicci PierGiuseppe
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):2112-6.
2002: Puccetti Elena; Obradovic Darja; Beissert Tim; Bianchini Andrea; Washburn Birgit; Chiaradonna Ferdinando; Boehrer Simone; Hoelzer Dieter; Ottmann Oliver Gerhard; Pelicci Pier Giuseppe; Nervi Clara; Ruthardt Martin
AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.
Cancer research 2002;62(23):7050-8.
2002: Ventura Andrea; Pelicci Pier Giuseppe
Semaphorins: green light for redox signaling?
Science's STKE : signal transduction knowledge environment 2002;2002(155):pe44.
2002: Minucci Saverio; Monestiroli Silvia; Giavara Sabrina; Ronzoni Simona; Marchesi Francesco; Insinga Alessandra; Diverio Daniela; Gasparini Patrizia; Capillo Manuela; Colombo Emanuela; Matteucci Cristian; Contegno Francesco; Lo-Coco Francesco; Scanziani Eugenio; Gobbi Alberto; Pelicci Pier Giuseppe
PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors.
Blood 2002;100(8):2989-95.
2002: Pelicci Giuliana; Troglio Flavia; Bodini Alessandra; Melillo Rosa Marina; Pettirossi Valentina; Coda Laura; De Giuseppe Antonio; Santoro Massimo; Pelicci Pier Giuseppe
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
Molecular and cellular biology 2002;22(20):7351-63.
2002: La Starza Roberta; Trubia Maurizio; Testoni Nicoletta; Ottaviani Emanuela; Belloni Elena; Crescenzi Barbara; Martelli Massimo; Flandrin Georges; Pelicci Pier Giuseppe; Mecucci Cristina
Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia.
Haematologica 2002;87(8):789-94.
2002: Petti Maria C; Fazi Francesco; Gentile Massimo; Diverio Daniela; De Fabritiis Paolo; De Propris M Stefania; Fiorini Roberto; Spiriti Maria A Aloe; Padula Fabrizio; Pelicci Pier Giuseppe; Nervi Clara; Lo Coco Francesco
Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies.
Blood 2002;100(3):1065-7.
2002: Migliorini Domenico; Lazzerini Denchi Eros; Danovi Davide; Jochemsen Aart; Capillo Manuela; Gobbi Alberto; Helin Kristian; Pelicci Pier Giuseppe; Marine Jean-Christophe
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.
Molecular and cellular biology 2002;22(15):5527-38.
2002: Pelicci Pier Giuseppe
A new class of anti-cancer drugs: HDAC-inhibitors.
I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.] 2002;1(4):S66.
2002: Puppo Francesca; Griseri Paola; Fanelli Mirco; Schena Francesca; Romeo Giovanni; Pelicci PierGiuseppe; Ceccherini Isabella; Ravazzolo Roberto; Patrone Giovanna
Cell-line specific chromatin acetylation at the Sox10-Pax3 enhancer site modulates the RET proto-oncogene expression.
FEBS letters 2002;523(1-3):123-7.
2002: Bischof Oliver; Kirsh Olivier; Pearson Mark; Itahana Koji; Pelicci Pier Giuseppe; Dejean Anne
Deconstructing PML-induced premature senescence.
The EMBO journal 2002;21(13):3358-69.
2002: Colombo Emanuela; Marine Jean-Christophe; Danovi Davide; Falini Brunangelo; Pelicci Pier Giuseppe
Nucleophosmin regulates the stability and transcriptional activity of p53.
Nature cell biology 2002;4(7):529-33.
2002: Ventura Andrea; Luzi Lucilla; Pacini Sonia; Baldari Cosima T; Pelicci Pier Giuseppe
The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.
The Journal of biological chemistry 2002;277(25):22370-6.
2002: Trinei Mirella; Giorgio Marco; Cicalese Angelo; Barozzi Sara; Ventura Andrea; Migliaccio Enrica; Milia Elisabetta; Padura Ines Martin; Raker Veronica A; Maccarana Marco; Petronilli Valeria; Minucci Saverio; Bernardi Paolo; Lanfrancone Luisa; Pelicci Pier Giuseppe
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Oncogene 2002;21(24):3872-8.
2002: Langley Emma; Pearson Mark; Faretta Mario; Bauer Uta-Maria; Frye Roy A; Minucci Saverio; Pelicci Pier Giuseppe; Kouzarides Tony
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
The EMBO journal 2002;21(10):2383-96.
2002: Tarr Philip E; Roncarati Roberta; Pelicci Giuliana; Pelicci Pier Giuseppe; D'Adamio Luciano
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
The Journal of biological chemistry 2002;277(19):16798-804.
2002: Carbone Roberta; Pearson Mark; Minucci Saverio; Pelicci Pier Giuseppe
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage.
Oncogene 2002;21(11):1633-40.
2002: Migliorini Domenico; Danovi Davide; Colombo Emanuela; Carbone Roberta; Pelicci Pier Giuseppe; Marine Jean-Christophe
Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation.
The Journal of biological chemistry 2002;277(9):7318-23.
2002: Contegno Francesco; Cioce Mario; Pelicci Pier Giuseppe; Minucci Saverio
Targeting protein inactivation through an oligomerization chain reaction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):1865-9.
2002: Di Croce Luciano; Raker Veronica A; Corsaro Massimo; Fazi Francesco; Fanelli Mirco; Faretta Mario; Fuks Francois; Lo Coco Francesco; Kouzarides Tony; Nervi Clara; Minucci Saverio; Pelicci Pier Giuseppe
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.
Science (New York, N.Y.) 2002;295(5557):1079-82.
2001: Göttlicher M; Minucci S; Zhu P; Krämer O H; Schimpf A; Giavara S; Sleeman J P; Lo Coco F; Nervi C; Pelicci P G; Heinzel T
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.
The EMBO journal 2001;20(24):6969-78.
2001: Pelicci P G
Inhibitors of histone-deacetylases.
Tumori 2001;87(6):S12-4.
2001: Pearson M; Pelicci P G
PML interaction with p53 and its role in apoptosis and replicative senescence.
Oncogene 2001;20(49):7250-6.
2001: Alcalay M; Orleth A; Sebastiani C; Meani N; Chiaradonna F; Casciari C; Sciurpi M T; Gelmetti V; Riganelli D; Minucci S; Fagioli M; Pelicci P G
Common themes in the pathogenesis of acute myeloid leukemia.
Oncogene 2001;20(40):5680-94.
2001: Malabarba M G; Milia E; Faretta M; Zamponi R; Pelicci P G; Di Fiore P P
A repertoire library that allows the selection of synthetic SH2s with altered binding specificities.
Oncogene 2001;20(37):5186-94.
2001: Salcini A E; Hilliard M A; Croce A; Arbucci S; Luzzi P; Tacchetti C; Daniell L; De Camilli P; Pelicci P G; Di Fiore P P; Bazzicalupo P
The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.
Nature cell biology 2001;3(8):755-60.
2001: Galandrini R; Tassi I; Morrone S; Lanfrancone L; Pelicci P; Piccoli M; Frati L; Santoni A
The adaptor protein shc is involved in the negative regulation of NK cell-mediated cytotoxicity.
European journal of immunology 2001;31(7):2016-25.
2001: Conti L; Sipione S; Magrassi L; Bonfanti L; Rigamonti D; Pettirossi V; Peschanski M; Haddad B; Pelicci P; Milanesi G; Pelicci G; Cattaneo E
Shc signaling in differentiating neural progenitor cells.
Nature neuroscience 2001;4(6):579-86.
2001: Minucci S; Nervi C; Lo Coco F; Pelicci P G
Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
Oncogene 2001;20(24):3110-5.
2001: Reymond A; Meroni G; Fantozzi A; Merla G; Cairo S; Luzi L; Riganelli D; Zanaria E; Messali S; Cainarca S; Guffanti A; Minucci S; Pelicci P G; Ballabio A
The tripartite motif family identifies cell compartments.
The EMBO journal 2001;20(9):2140-51.
2001: Nervi C; Borello U; Fazi F; Buffa V; Pelicci P G; Cossu G
Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.
Cancer research 2001;61(4):1247-9.
2001: Ferrara F F; Fazi F; Bianchini A; Padula F; Gelmetti V; Minucci S; Mancini M; Pelicci P G; Lo Coco F; Nervi C
Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia.
Cancer research 2001;61(1):2-7.
2001: Faretta M; Di Croce L; Pelicci P G
Effects of the acute myeloid leukemia--associated fusion proteins on nuclear architecture.
Seminars in hematology 2001;38(1):42-53.
2001: Zhang J; Hug B A; Huang E Y; Chen C W; Gelmetti V; Maccarana M; Minucci S; Pelicci P G; Lazar M A
Oligomerization of ETO is obligatory for corepressor interaction.
Molecular and cellular biology 2001;21(1):156-63.
2000: Santolini E; Puri C; Salcini A E; Gagliani M C; Pelicci P G; Tacchetti C; Di Fiore P P
Numb is an endocytic protein.
The Journal of cell biology 2000;151(6):1345-52.
2000: Luzi L; Confalonieri S; Di Fiore P P; Pelicci P G
Evolution of Shc functions from nematode to human.
Current opinion in genetics & development 2000;10(6):668-74.
2000: Vannucchi S; Percario Z A; Chiantore M V; Matarrese P; Chelbi-Alix M K; Fagioli M; Pelicci P G; Malorni W; Fiorucci G; Romeo G; Affabris E
Interferon-beta induces S phase slowing via up-regulated expression of PML in squamous carcinoma cells.
Oncogene 2000;19(44):5041-53.
2000: Di Florio S; Sebastiani C; Fagioli M; Di Ianni M; Alfonsi D; Venditti G; Pelicci P G; Tabilio A
Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and enhanced green fluorescence protein genes in primary T lymphocytes.
British journal of haematology 2000;110(4):903-6.
2000: Grignani F; Valtieri M; Gabbianelli M; Gelmetti V; Botta R; Luchetti L; Masella B; Morsilli O; Pelosi E; Samoggia P; Pelicci P G; Peschle C
PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype.
Blood 2000;96(4):1531-7.
2000: Pearson M; Carbone R; Sebastiani C; Cioce M; Fagioli M; Saito S; Higashimoto Y; Appella E; Minucci S; Pandolfi P P; Pelicci P G
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.
Nature 2000;406(6792):207-10.
2000: Minucci S; Maccarana M; Cioce M; De Luca P; Gelmetti V; Segalla S; Di Croce L; Giavara S; Matteucci C; Gobbi A; Bianchini A; Colombo E; Schiavoni I; Badaracco G; Hu X; Lazar M A; Landsberger N; Nervi C; Pelicci P G
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.
Molecular cell 2000;5(5):811-20.
2000: Plyte S; Majolini M B; Pacini S; Scarpini F; Bianchini C; Lanfrancone L; Pelicci P; Baldari C T
Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts.
Oncogene 2000;19(12):1529-37.
2000: Trinei M; Lanfrancone L; Campo E; Pulford K; Mason D Y; Pelicci P G; Falini B
A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma.
Cancer research 2000;60(4):793-8.
1999: Doria M; Salcini A E; Colombo E; Parslow T G; Pelicci P G; Di Fiore P P
The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.
The Journal of cell biology 1999;147(7):1379-84.
1999: Grignani F; Gelmetti V; Fanelli M; Rogaia D; De Matteis S; Ferrara F F; Bonci D; Grignani F; Nervi C; Pelicci P G
Formation of PML/RAR alpha high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML/RAR alpha-mediated retinoic acid response.
Oncogene 1999;18(46):6313-21.
1999: Migliaccio E; Giorgio M; Mele S; Pelicci G; Reboldi P; Pandolfi P P; Lanfrancone L; Pelicci P G
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Nature 1999;402(6759):309-13.
1999: Falini B; Pulford K; Pucciarini A; Carbone A; De Wolf-Peeters C; Cordell J; Fizzotti M; Santucci A; Pelicci P G; Pileri S; Campo E; Ott G; Delsol G; Mason D Y
Lymphomas expressing ALK fusion protein(s) other than NPM-ALK.
Blood 1999;94(10):3509-15.
1999: Lo Coco F; Diverio D; Falini B; Biondi A; Nervi C; Pelicci P G
Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia.
Blood 1999;94(1):12-22.
1999: Minucci S; Cioce M; Maccarana M; Pelicci P G
The APL-associated fusion proteins.
Haematologica 1999;84 Suppl EHA-4():70-1.
1999: Mozziconacci M J; Liberatore C; Grignani F; Sainty D; Pelicci P G; Birg F; Lafage-Pochitaloff M
Atypical response to all-trans retinoic acid in a der(5)t(5;17) acute promyelocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(6):862-8.
1999: Casini T; Pelicci P G
A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest.
Oncogene 1999;18(21):3235-43.
1999: Minucci S; Pelicci P G
Retinoid receptors in health and disease: co-regulators and the chromatin connection.
Seminars in cell & developmental biology 1999;10(2):215-25.
1999: Falini B; Pileri S; Zinzani P L; Carbone A; Zagonel V; Wolf-Peeters C; Verhoef G; Menestrina F; Todeschini G; Paulli M; Lazzarino M; Giardini R; Aiello A; Foss H D; Araujo I; Fizzotti M; Pelicci P G; Flenghi L; Martelli M F; Santucci A
ALK+ lymphoma: clinico-pathological findings and outcome.
Blood 1999;93(8):2697-706.
1999: Fanelli M; Minucci S; Gelmetti V; Nervi C; Gambacorti-Passerini C; Pelicci P G
Constitutive degradation of PML/RARalpha through the proteasome pathway mediates retinoic acid resistance.
Blood 1999;93(5):1477-81.
1999: Torrisi M R; Lotti L V; Belleudi F; Gradini R; Salcini A E; Confalonieri S; Pelicci P G; Di Fiore P P
Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization.
Molecular biology of the cell 1999;10(2):417-34.
1999: Gottifredi V; Pelicci G; Munarriz E; Maione R; Pelicci P G; Amati P
Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.
Journal of virology 1999;73(2):1427-37.
1999: Cordell J L; Pulford K A; Bigerna B; Roncador G; Banham A; Colombo E; Pelicci P G; Mason D Y; Falini B
Detection of normal and chimeric nucleophosmin in human cells.
Blood 1999;93(2):632-42.
1998: Gelmetti V; Zhang J; Fanelli M; Minucci S; Pelicci P G; Lazar M A
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.
Molecular and cellular biology 1998;18(12):7185-91.
1998: Cattaneo E; Pelicci P G
Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain.
Trends in neurosciences 1998;21(11):476-81.
1998: Paoluzi S; Castagnoli L; Lauro I; Salcini A E; Coda L; Fre' S; Confalonieri S; Pelicci P G; Di Fiore P P; Cesareni G
Recognition specificity of individual EH domains of mammals and yeast.
The EMBO journal 1998;17(22):6541-50.
1998: Nervi C; Ferrara F F; Fanelli M; Rippo M R; Tomassini B; Ferrucci P F; Ruthardt M; Gelmetti V; Gambacorti-Passerini C; Diverio D; Grignani F; Pelicci P G; Testi R
Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein.
Blood 1998;92(7):2244-51.
1998: Falini B; Bigerna B; Fizzotti M; Pulford K; Pileri S A; Delsol G; Carbone A; Paulli M; Magrini U; Menestrina F; Giardini R; Pilotti S; Mezzelani A; Ugolini B; Billi M; Pucciarini A; Pacini R; Pelicci P G; Flenghi L
ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum.
The American journal of pathology 1998;153(3):875-86.
1998: Pacini S; Ulivieri C; Di Somma M M; Isacchi A; Lanfrancone L; Pelicci P G; Telford J L; Baldari C T
Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation.
The Journal of biological chemistry 1998;273(32):20487-93.
1998: Mozziconacci M J; Liberatore C; Brunel V; Grignani F; Arnoulet C; Ferrucci P F; Fernandez F; Sainty D; Pelicci P G; Birg F; Lafage-Pochitaloff M
In vitro response to all-trans retinoic acid of acute promyelocytic leukemias with nonreciprocal PML/RARA or RARA/PML fusion genes.
Genes, chromosomes & cancer 1998;22(3):241-50.
1998: Fagioli M; Alcalay M; Tomassoni L; Ferrucci P F; Mencarelli A; Riganelli D; Grignani F; Pozzan T; Nicoletti I; Grignani F; Pelicci P G
Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival.
Oncogene 1998;16(22):2905-13.
1998: Testa U; Grignani F; Samoggia P; Zanetti C; Riccioni R; Lo Coco F; Diverio D; Felli N; Passerini C G; Grell M; Pelicci P G; Peschle C
The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.
The Journal of clinical investigation 1998;101(10):2278-89.
1998: Ruthardt M; Orleth A; Tomassoni L; Puccetti E; Riganelli D; Alcalay M; Mannucci R; Nicoletti I; Grignani F; Fagioli M; Pelicci P G
The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies.
Oncogene 1998;16(15):1945-53.
1998: Testa U; Grignani F; Hassan H J; Rogaia D; Masciulli R; Gelmetti V; Guerriero R; Macioce G; Liberatore C; Barberi T; Mariani G; Pelicci P G; Peschle C
Terminal megakaryocytic differentiation of TF-1 cells is induced by phorbol esters and thrombopoietin and is blocked by expression of PML/RARalpha fusion protein.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(4):563-70.
1998: Grignani F; De Matteis S; Nervi C; Tomassoni L; Gelmetti V; Cioce M; Fanelli M; Ruthardt M; Ferrara F F; Zamir I; Seiser C; Grignani F; Lazar M A; Minucci S; Pelicci P G
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
Nature 1998;391(6669):815-8.
1998: Alcalay M; Tomassoni L; Colombo E; Stoldt S; Grignani F; Fagioli M; Szekely L; Helin K; Pelicci P G
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein.
Molecular and cellular biology 1998;18(2):1084-93.
1998: Shao W; Fanelli M; Ferrara F F; Riccioni R; Rosenauer A; Davison K; Lamph W W; Waxman S; Pelicci P G; Lo Coco F; Avvisati G; Testa U; Peschle C; Gambacorti-Passerini C; Nervi C; Miller W H
Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells.
Journal of the National Cancer Institute 1998;90(2):124-33.
1998: Coda L; Salcini A E; Confalonieri S; Pelicci G; Sorkina T; Sorkin A; Pelicci P G; Di Fiore P P
Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization.
The Journal of biological chemistry 1998;273(5):3003-12.
1998: Grignani F; Kinsella T; Mencarelli A; Valtieri M; Riganelli D; Grignani F; Lanfrancone L; Peschle C; Nolan G P; Pelicci P G
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.
Cancer research 1998;58(1):14-9.
1997: Carbone R; Fré S; Iannolo G; Belleudi F; Mancini P; Pelicci P G; Torrisi M R; Di Fiore P P
eps15 and eps15R are essential components of the endocytic pathway.
Cancer research 1997;57(24):5498-504.
1997: Falini B; Flenghi L; Fagioli M; Lo Coco F; Cordone I; Diverio D; Pasqualucci L; Biondi A; Riganelli D; Orleth A; Liso A; Martelli M F; Pelicci P G; Pileri S
Immunocytochemical diagnosis of acute promyelocytic leukemia (M3) with the monoclonal antibody PG-M3 (anti-PML).
Blood 1997;90(10):4046-53.
1997: Ferrucci P F; Grignani F; Pearson M; Fagioli M; Nicoletti I; Pelicci P G
Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10901-6.
1997: Salcini A E; Confalonieri S; Doria M; Santolini E; Tassi E; Minenkova O; Cesareni G; Pelicci P G; Di Fiore P P
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.
Genes & development 1997;11(17):2239-49.
1997: Benedetti L; Levin A A; Scicchitano B M; Grignani F; Allenby G; Diverio D; Lo Coco F; Avvisati G; Ruthardt M; Adamo S; Pelicci P G; Nervi C
Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells.
Blood 1997;90(3):1175-85.
1997: Mandelli F; Diverio D; Avvisati G; Luciano A; Barbui T; Bernasconi C; Broccia G; Cerri R; Falda M; Fioritoni G; Leoni F; Liso V; Petti M C; Rodeghiero F; Saglio G; Vegna M L; Visani G; Jehn U; Willemze R; Muus P; Pelicci P G; Biondi A; Lo Coco F
Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano-Malattie Ematologiche Maligne dell'Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups.
Blood 1997;90(3):1014-21.
1997: Ruthardt M; Testa U; Nervi C; Ferrucci P F; Grignani F; Puccetti E; Grignani F; Peschle C; Pelicci P G
Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.
Molecular and cellular biology 1997;17(8):4859-69.
1997: Dente L; Vetriani C; Zucconi A; Pelicci G; Lanfrancone L; Pelicci P G; Cesareni G
Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides.
Journal of molecular biology 1997;269(5):694-703.
1997: Giordano V; De Falco G; Chiari R; Quinto I; Pelicci P G; Bartholomew L; Delmastro P; Gadina M; Scala G
Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4097-103.
1997: Rogaia D; Grignani F; Carbone R; Riganelli D; LoCoco F; Nakamura T; Croce C M; Di Fiore P P; Pelicci P G
The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner.
Cancer research 1997;57(5):799-802.
1997: Tortora G; Damiano V; Bianco C; Baldassarre G; Bianco A R; Lanfrancone L; Pelicci P G; Ciardiello F
The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor.
Oncogene 1997;14(8):923-8.
1997: Migliaccio E; Mele S; Salcini A E; Pelicci G; Lai K M; Superti-Furga G; Pawson T; Di Fiore P P; Lanfrancone L; Pelicci P G
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
The EMBO journal 1997;16(4):706-16.
1997: Casini T; Grignani F; Pelicci P G
Genetics of APL and the molecular basis of retinoic acid treatment.
International journal of cancer. Journal international du cancer 1997;70(4):473-4.
1997: Iannolo G; Salcini A E; Gaidarov I; Goodman O B; Baulida J; Carpenter G; Pelicci P G; Di Fiore P P; Keen J H
Mapping of the molecular determinants involved in the interaction between eps15 and AP-2.
Cancer research 1997;57(2):240-5.
1996: Gambacorta M; Flenghi L; Fagioli M; Pileri S; Leoncini L; Bigerna B; Pacini R; Tanci L N; Pasqualucci L; Ascani S; Mencarelli A; Liso A; Pelicci P G; Falini B
Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues.
The American journal of pathology 1996;149(6):2023-35.
1996: Raelson J V; Nervi C; Rosenauer A; Benedetti L; Monczak Y; Pearson M; Pelicci P G; Miller W H
The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells.
Blood 1996;88(8):2826-32.
1996: Grignani F; Testa U; Rogaia D; Ferrucci P F; Samoggia P; Pinto A; Aldinucci D; Gelmetti V; Fagioli M; Alcalay M; Seeler J; Grignani F; Nicoletti I; Peschle C; Pelicci P G
Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.
The EMBO journal 1996;15(18):4949-58.
1996: Terenzi A; Aversa F; Mencarelli A; Pelicci P; Velardi A; Perruccio K; Martelli M F
Unusual split chimaerism after mismatched T-depleted BMT.
Bone marrow transplantation 1996;18(2):465-7.
1996: Milia E; Di Somma M M; Baldoni F; Chiari R; Lanfrancone L; Pelicci P G; Telford J L; Baldari C T
The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation.
Oncogene 1996;13(4):767-75.
1996: Pelicci G; Dente L; De Giuseppe A; Verducci-Galletti B; Giuli S; Mele S; Vetriani C; Giorgio M; Pandolfi P P; Cesareni G; Pelicci P G
A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
Oncogene 1996;13(3):633-41.
1996: Brunel V; Lafage-Pochitaloff M; Alcalay M; Pelicci P G; Birg F
Variant and masked translocations in acute promyelocytic leukemia.
Leukemia & lymphoma 1996;22(3-4):221-8.
1996: Bonfini L; Migliaccio E; Pelicci G; Lanfrancone L; Pelicci P G
Not all Shc's roads lead to Ras.
Trends in biochemical sciences 1996;21(7):257-61.
1996: Lotti L V; Lanfrancone L; Migliaccio E; Zompetta C; Pelicci G; Salcini A E; Falini B; Pelicci P G; Torrisi M R
Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.
Molecular and cellular biology 1996;16(5):1946-54.
1996: Flenghi L; Bigerna B; Fizzotti M; Venturi S; Pasqualucci L; Pileri S; Ye B H; Gambacorta M; Pacini R; Baroni C D; Pescarmona E; Anagnostopoulos I; Stein H; Asdrubali G; Martelli M F; Pelicci P G; Dalla-Favera R; Falini B
Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region.
The American journal of pathology 1996;148(5):1543-55.
1996: Benedetti L; Grignani F; Scicchitano B M; Jetten A M; Diverio D; Lo Coco F; Avvisati G; Gambacorti-Passerini C; Adamo S; Levin A A; Pelicci P G; Nervi C
Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
Blood 1996;87(5):1939-50.
1996: Tribioli C; Droetto S; Bione S; Cesareni G; Torrisi M R; Lotti L V; Lanfrancone L; Toniolo D; Pelicci P
An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):695-9.
1996: Falini B; Bigerna B; Pasqualucci L; Fizzotti M; Martelli M F; Pileri S; Pinto A; Carbone A; Venturi S; Pacini R; Cattoretti G; Pescarmona E; Lo Coco F; Pelicci P G; Anagnastopoulos I; Dalla-Favera R; Flenghi L
Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease.
Blood 1996;87(2):465-71.
1996: Grignani F; Pelicci P G
Pathogenetic role of the PML1RAR alpha fusion protein in acute promyelocytic leukemia.
Current topics in microbiology and immunology 1996;211():269-78.
1995: Wong W T; Schumacher C; Salcini A E; Romano A; Castagnino P; Pelicci P G; Di Fiore P P
A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9530-4.
1995: Ricci A; Lanfrancone L; Chiari R; Belardo G; Pertica C; Natali P G; Pelicci P G; Segatto O
Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.
Oncogene 1995;11(8):1519-29.
1995: Pelicci G; Lanfrancone L; Salcini A E; Romano A; Mele S; Grazia Borrello M; Segatto O; Di Fiore P P; Pelicci P G
Constitutive phosphorylation of Shc proteins in human tumors.
Oncogene 1995;11(5):899-907.
1995: Rogaia D; Grignani F; Grignani F; Nicoletti I; Pelicci P G
The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(9):1467-72.
1995: Matoskova B; Wong W T; Salcini A E; Pelicci P G; Di Fiore P P
Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation.
Molecular and cellular biology 1995;15(7):3805-12.
1995: Fizzotti M; Cimino G; Pisegna S; Alimena G; Quartarone C; Mandelli F; Pelicci P G; Lo Coco F
Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features.
Blood 1995;85(10):2685-90.
1995: Pelicci G; Giordano S; Zhen Z; Salcini A E; Lanfrancone L; Bardelli A; Panayotou G; Waterfield M D; Ponzetto C; Pelicci P G
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.
Oncogene 1995;10(8):1631-8.
1995: Lanfrancone L; Pelicci G; Brizzi M F; Aronica M G; Casciari C; Giuli S; Pegoraro L; Pawson T; Pelicci P G; Arouica M G
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.
Oncogene 1995;10(5):907-17.
1995: Lafage-Pochitaloff M; Alcalay M; Brunel V; Longo L; Sainty D; Simonetti J; Birg F; Pelicci P G
Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes.
Blood 1995;85(5):1169-74.
1995: Baldari C T; Pelicci G; Di Somma M M; Milia E; Giuli S; Pelicci P G; Telford J L
Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.
Oncogene 1995;10(6):1141-7.
1995: Grignani F; Testa U; Fagioli M; Barberi T; Masciulli R; Mariani G; Peschle C; Pelicci P G
Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells.
Cancer research 1995;55(2):440-3.
1994: Salcini A E; McGlade J; Pelicci G; Nicoletti I; Pawson T; Pelicci P G
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.
Oncogene 1994;9(10):2827-36.
1994: Testa U; Grignani F; Barberi T; Fagioli M; Masciulli R; Ferrucci P F; Seripa D; Camagna A; Alcalay M; Pelicci P G
PML/RAR alpha+ U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3.
Cancer research 1994;54(16):4508-15.
1994: Diverio D; Pandolfi P P; Rossi V; Biondi A; Pelicci P G; Lo Coco F
Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(7):1105-7.
1994: Fagioli M; Grignani F; Ferrucci P F; Alcalay M; Mencarelli A; Nicoletti I; Grignani F; Pelicci P G
Effect of the acute promyelocytic leukemia PML/RAR alpha protein on differentiation and survival of myeloid precursors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8 Suppl 1():S7-11.
1994: Lo Coco F; D'Adamo F; Diverio D; Pelicci P G; Saglio G
Polyclonal hemopoiesis in leukemia patients following molecularly documented remission.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8 Suppl 1():S137-9.
1994: Lo Coco F; Pelicci P G; Biondi A
Clinical relevance of the PML/RAR-a gene rearrangement in acute promyelocytic leukaemia.
Leukemia & lymphoma 1994;12(5-6):327-32.
1994: Puil L; Liu J; Gish G; Mbamalu G; Bowtell D; Pelicci P G; Arlinghaus R; Pawson T
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
The EMBO journal 1994;13(4):764-73.
1994: Grignani F; Fagioli M; Alcalay M; Longo L; Pandolfi P P; Donti E; Biondi A; Lo Coco F; Grignani F; Pelicci P G
Acute promyelocytic leukemia: from genetics to treatment.
Blood 1994;83(1):10-25.
1994: Diverio D; Pandolfi P P; Rossi V; Biondi A; Pelicci P G; Lo Coco F
Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8 Suppl 2():S63-5.
1993: Longo L; Trecca D; Biondi A; Lo Coco F; Grignani F; Maiolo A T; Pelicci P G; Neri A
Frequency of RAS and p53 mutations in acute promyelocytic leukemias.
Leukemia & lymphoma 1993;11(5-6):405-10.
1993: Segatto O; Pelicci G; Giuli S; Digiesi G; Di Fiore P P; McGlade J; Pawson T; Pelicci P G
Shc products are substrates of erbB-2 kinase.
Oncogene 1993;8(8):2105-12.
1993: Lo Coco F; Pelicci P G; D'Adamo F; Diverio D; Alimena G; Montefusco E; Arcese W; Avvisati G; De Felice L; Meloni G
Polyclonal hematopoietic reconstitution in leukemia patients at remission after suppression of specific gene rearrangements.
Blood 1993;82(2):606-12.
1993: Grignani F; Fagioli M; Ferrucci P F; Alcalay M; Pelicci P G
The molecular genetics of acute promyelocytic leukemia.
Blood reviews 1993;7(2):87-93.
1993: Huebner K; Druck T; LaForgia S; Lasota J; Croce C M; Lanfrancone L; Donti E; Pengue G; La Mantia G; Pelicci P G
Chromosomal localization of four human zinc finger cDNAs.
Human genetics 1993;91(3):217-22.
1993: Biondi A; Rambaldi A; Pandolfi P P; Alcalay M; Longo L; Rossi V; Giudici G; Lo Coco F; Pelicci P G
Molecular genetics of the t(15;17) translocation in acute promyelocytic leukemia.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;131():345-59.
1992: Rozakis-Adcock M; McGlade J; Mbamalu G; Pelicci G; Daly R; Li W; Batzer A; Thomas S; Brugge J; Pelicci P G
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.
Nature 1992;360(6405):689-92.
1992: McGlade J; Cheng A; Pelicci G; Pelicci P G; Pawson T
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8869-73.
1992: Pelicci G; Lanfrancone L; Grignani F; McGlade J; Cavallo F; Forni G; Nicoletti I; Grignani F; Pawson T; Pelicci P G
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Cell 1992;70(1):93-104.
1992: Fagioli M; Alcalay M; Pandolfi P P; Venturini L; Mencarelli A; Simeone A; Acampora D; Grignani F; Pelicci P G
Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Oncogene 1992;7(6):1083-91.
1992: Alcalay M; Zangrilli D; Fagioli M; Pandolfi P P; Mencarelli A; Lo Coco F; Biondi A; Grignani F; Pelicci P G
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4840-4.
1992: Lanfrancone L; Pengue G; Pandolfi P P; Salcini A E; Giacomucci A; Longo L; Donti E; De Luca P; La Mantia G; Pelicci P G
Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22.
Genomics 1992;12(4):720-8.
1992: Lo Coco F; Diverio D; D'Adamo F; Avvisati G; Alimena G; Nanni M; Alcalay M; Pandolfi P P; Pelicci P G
PML/RAR-alpha rearrangement in acute promyelocytic leukaemias apparently lacking the t(15;17) translocation.
European journal of haematology 1992;48(3):173-6.
1991: Donti E; Longo L; Pelicci P G
Chromosomal localization of the APL t(15;17) breakpoints by molecular cytogenetic analysis.
Cancer genetics and cytogenetics 1991;54(2):265-6.
1991: Pandolfi P P; Grignani F; Alcalay M; Mencarelli A; Biondi A; LoCoco F; Grignani F; Pelicci P G
Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.
Oncogene 1991;6(7):1285-92.
1991: Falini B; Flenghi L; Fagioli M; Pelicci P G; Stein H; Bigerna B; Pileri S; Martelli M F
Expression of the intestinal T-lymphocyte associated molecule HML-1: analysis of 75 non-Hodgkin's lymphomas and description of the first HML-1 positive T-lymphoblastic tumour.
Histopathology 1991;18(5):421-6.
1991: Aversa F; Pelicci P G; Terenzi A; Carotti A; Felicini R; Mencarelli A; Donti E; Latini P; Aristei C; Martelli M F
Results of T-depleted BMT in chronic myelogenous leukaemia after a conditioning regimen that included thiotepa.
Bone marrow transplantation 1991;7 Suppl 2():24.
1990: Longo L; Donti E; Mencarelli A; Avanzi G; Pegoraro L; Alimena G; Tabilio A; Venti G; Grignani F; Pelicci P G
Mapping of chromosome 17 breakpoints in acute myeloid leukemias.
Oncogene 1990;5(10):1557-63.
1990: Fagioli M; Ciccone E; Bottino C; Falini B; Grignani F; Moretta A; Moretta L; Pelicci P G
The C gamma 1-encoded disulphide-linked and the C gamma 2-encoded nondisulphide-linked forms of the gamma/delta heterodimer use different gamma and delta variable regions.
Blood 1990;76(2):279-84.
1990: Carè A; Pelicci P G; Meccia E; Fagioli M; Testa U; Ciccone E; Moretta A; Moretta L; Peschle C
Natural killer cells carry the germ-line configuration of the T cell receptor delta chain gene and heterogeneously express six distinct delta transcripts.
European journal of immunology 1990;20(4):939-42.
1990: Donti E; Lanfrancone L; Huebner K; Pascucci A; Venti G; Pengue G; Grignani F; Croce C M; Lania L; Pelicci P G
Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers.
Human genetics 1990;84(5):391-5.
1990: Alcalay M; Antolini F; Van de Ven W J; Lanfrancone L; Grignani F; Pelicci P G
Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.
Oncogene 1990;5(3):267-75.
1990: Lania L; Donti E; Pannuti A; Pascucci A; Pengue G; Feliciello I; La Mantia G; Lanfrancone L; Pelicci P G
cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes.
Genomics 1990;6(2):333-40.
1990: Fagioli M; Carè A; Ciccone E; Moretta L; Moretta A; Testa U; Falini B; Grignani F; Peschle C; Pelicci P G
Molecular studies on LAK cells.
Annali dell'Istituto superiore di sanità 1990;26(3-4):357-68.
1989: Falini B; Flenghi L; Fagioli M; Martelli M F; Pileri S; Grignani F; Beltrami A; Novero D; Pelicci P G
T-lymphoblastic lymphomas expressing the non-disulfide-linked form of the T-cell receptor gamma/delta: characterization with monoclonal antibodies and genotypic analysis.
Blood 1989;74(7):2501-7.
1989: Falini B; Flenghi L; Pileri S; Pelicci P; Fagioli M; Martelli M F; Moretta L; Ciccone E
Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(8):2480-8.
1988: Pannuti A; Lanfrancone L; Pascucci A; Pelicci P G; La Mantia G; Lania L
Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation.
Nucleic acids research 1988;16(10):4227-37.

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