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Luca Pellegrini

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John K Blackwood; Sian M Bray; Joseph D Maman; Luca Pellegrini; Neil J Rzechorzek; Nicholas P Robinson
End-resection at DNA double-strand breaks in the three domains of life.
Rajika L Perera; Rubben Torella; Mairi L Kilkenny; Sebastian Klinge; Joseph D Maman; Luca Pellegrini
Mechanism for priming DNA synthesis by yeast DNA Polymerase α.
Mairi L Kilkenny; Karim Labib; Giacomo De Piccoli; Rajika L Perera; Luca Pellegrini
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.

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All Publications

2013: John K Blackwood; Sian M Bray; Joseph D Maman; Luca Pellegrini; Neil J Rzechorzek; Nicholas P Robinson
End-resection at DNA double-strand breaks in the three domains of life.
Biochemical Society transactions 2013;41(1):314-20.
2013: Rajika L Perera; Rubben Torella; Mairi L Kilkenny; Sebastian Klinge; Joseph D Maman; Luca Pellegrini
Mechanism for priming DNA synthesis by yeast DNA Polymerase α.
eLife 2013;2():e00482.
2012: Mairi L Kilkenny; Karim Labib; Giacomo De Piccoli; Rajika L Perera; Luca Pellegrini
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.
The Journal of biological chemistry 2012;287(28):23740-7.
2012: Owen R Davies; Joseph D Maman; Luca Pellegrini
Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.
Open biology 2012;2(7):120099.
2012: John K Blackwood; Joseph D Maman; Luca Pellegrini; Andrew S Abrams; Neil J Rzechorzek; Nicholas P Robinson
Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex.
Nucleic acids research 2012;40(7):3183-96.
2012: Luca Pellegrini
The Pol α-Primase Complex.
Sub-cellular biochemistry 2012;62():157-69.
2011: Rafael Núñez-Ramírez; Luca Pellegrini; Rajika L Perera; María A Recuero-Checa; Ludovic Sauguet; Begoña García-Alvarez; Richard J Hall; Mairi Kilkenny; Sebastian Klinge; Roberto Melero; Eva Nogales; Oscar Llorca
Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.
Nucleic acids research 2011;39(18):8187-99.
2010: Ludovic Sauguet; Sebastian Klinge; Rajika Perera; Joseph D Maman; Luca Pellegrini
Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase.
PloS one 2010;5(4):e10083.
2009: Sebastian Klinge; Rafael Núñez-Ramírez; Oscar Llorca; Luca Pellegrini
3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases.
The EMBO journal 2009;28(13):1978-87.
2008: Stefania Ragone; Joseph D Maman; Nicholas Furnham; Luca Pellegrini
Structural basis for inhibition of homologous recombination by the RecX protein.
The EMBO journal 2008;27(16):2259-69.
2007: Sebastian Klinge; Judy Hirst; Joseph D Maman; Torsten Krude; Luca Pellegrini
An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis.
Nature structural & molecular biology 2007;14(9):875-7.
2007: Owen Richard Davies; Luca Pellegrini
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats.
Nature structural & molecular biology 2007;14(6):475-83.
2007: Ravi K Nookala; Shobbir Hussain; Luca Pellegrini
Insights into Fanconi Anaemia from the structure of human FANCE.
Nucleic acids research 2007;35(5):1638-48.
2006: Andrew S Doré; Nicholas Furnham; Owen Richard Davies; Bancinyane L Sibanda; Dimitri Y Chirgadze; Stephen P Jackson; Luca Pellegrini; Tom L Blundell
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA repair 2006;5(3):362-8.
2006: Mahmud K K Shivji; Owen Richard Davies; Jane M Savill; Debbie L Bates; Luca Pellegrini; Ashok R Venkitaraman
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange.
Nucleic acids research 2006;34(14):4000-11.
2005: Si-Houy Lao-Sirieix; Ravi K Nookala; Pietro Roversi; Steve Bell; Luca Pellegrini
Structure of the heterodimeric core primase.
Nature structural & molecular biology 2005;12(12):1137-44.
2005: Si-Houy Lao-Sirieix; Luca Pellegrini; Steve Bell
The promiscuous primase.
Trends in genetics : TIG 2005;21(10):568-72.
2004: Nicholas J Harmer; Leopold L Ilag; Barbara Mulloy; Luca Pellegrini; Carol V Robinson; Tom L Blundell
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex.
Journal of molecular biology 2004;339(4):821-34.
2004: Luca Pellegrini; Ashok R Venkitaraman
Emerging functions of BRCA2 in DNA recombination.
Trends in biochemical sciences 2004;29(6):310-6.
2004: Nicholas J Harmer; Luca Pellegrini; Dimitri Y Chirgadze; Juan Fernandez-Recio; Tom L Blundell
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.
Biochemistry 2004;43(3):629-40.
2003: David S Yu; Eiichiro Sonoda; Shunichi Takeda; Christopher L-H Huang; Luca Pellegrini; Tom L Blundell; Ashok R Venkitaraman
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.
Molecular cell 2003;12(4):1029-41.
2003: Thomas Lo; Luca Pellegrini; Ashok R Venkitaraman; Tom L Blundell
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
DNA repair 2003;2(9):1015-28.
2003: David S Shin; Luca Pellegrini; Douglas S Daniels; Biana Yelent; Lisa Craig; Debbie Bates; David S Yu; Mahmud K K Shivji; Chiharu Hitomi; Andrew S Arvai; Niels Volkmann; Hiro Tsuruta; Tom L Blundell; Ashok R Venkitaraman; John A Tainer
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
The EMBO journal 2003;22(17):4566-76.
2003: Nicholas J Harmer; Dimitri Y Chirgadze; Kyung Hyun Kim; Luca Pellegrini; Tom L Blundell
The structural biology of growth factor receptor activation.
Biophysical chemistry 2003;100(1-3):545-53.
2002: Luca Pellegrini; David S Yu; Thomas Lo; Shubha Anand; MiYoung Lee; Tom L Blundell; Ashok R Venkitaraman
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Nature 2002;420(6913):287-93.
2001: Bancinyane L Sibanda; S E Critchlow; J Begun; X Y Pei; Stephen P Jackson; Tom L Blundell; Luca Pellegrini
Crystal structure of an Xrcc4-DNA ligase IV complex.
Nature structural biology 2001;8(12):1015-9.
2001: Luca Pellegrini
Role of heparan sulfate in fibroblast growth factor signalling: a structural view.
Current opinion in structural biology 2001;11(5):629-34.
2001: H G Nagendra; A E Harrington; Nicholas J Harmer; Luca Pellegrini; Tom L Blundell; david burke
Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution.
FEBS letters 2001;501(1):51-8.
2000: Luca Pellegrini; david burke; Frank von Delft; Barbara Mulloy; Tom L Blundell
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.
Nature 2000;407(6807):1029-34.
2000: Tom L Blundell; david burke; Dimitri Y Chirgadze; Venugopal Dhanaraj; Marko Hyvönen; C Axel Innis; Emilio Parisini; Luca Pellegrini; Muhammed Sayed; Bancinyane L Sibanda
Protein-protein interactions in receptor activation and intracellular signalling.
Biological chemistry 2000;381(9-10):955-9.
1998: Luca Pellegrini; P Commander; Barbara Mulloy; M Martin-Martinez; Tom L Blundell; david burke
The role of heparin in the complex formation between fibroblast growth factor 2 and its high affinity receptor: comparative modelling and biochemical studies.
Biochemical Society transactions 1998;26(3):545-9.