FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jean-Pierre Pelletier

Research Profile

Disorders

Anatomy

Chemicals & Drugs

Living Beings

Dogs

Physiology

Disease Progression

Co-author Network

Publications

TOP 3
Faezeh Vasheghani; Yue Zhang; Frank Beier; Meryem Blati; Hassan Fahmi; Johanne Martel-Pelletier; Roxana Monemdjou; Jean-Pierre Pelletier; Gemma Perez; René St-Arnaud; Mohit Kapoor
Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype.
Camille Roubille; Jean-Marc Davy; Boulos Haraoui; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Cardiovascular adverse effects of anti-inflammatory drugs.
Camille Roubille; Jean-Claude Tardif; Boulos Haraoui; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Biologics and the cardiovascular system: a double-edged sword.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jean-Pierre Pelletier (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Faezeh Vasheghani; Yue Zhang; Frank Beier; Meryem Blati; Hassan Fahmi; Johanne Martel-Pelletier; Roxana Monemdjou; Jean-Pierre Pelletier; Gemma Perez; René St-Arnaud; Mohit Kapoor
Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype.
The American journal of pathology 2013;182(4):1099-106.
2013: Camille Roubille; Jean-Marc Davy; Boulos Haraoui; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Cardiovascular adverse effects of anti-inflammatory drugs.
Anti-inflammatory & anti-allergy agents in medicinal chemistry 2013;12(1):55-67.
2013: Camille Roubille; Jean-Claude Tardif; Boulos Haraoui; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Biologics and the cardiovascular system: a double-edged sword.
Anti-inflammatory & anti-allergy agents in medicinal chemistry 2013;12(1):68-82.
2012: Martin Guillot; Johanne Martel-Pelletier; Maxim Moreau; Jean-Pierre Pelletier; Marc-André d'Anjou; Eric Troncy
Evaluation of osteoarthritis in cats: novel information from a pilot study.
Veterinary surgery : VS 2012;41(3):328-35.
2012: Mohit Kapoor; François Mineau; Jean-Pierre Pelletier; Hassan Fahmi; Johanne Martel-Pelletier
Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1.
The Journal of rheumatology 2012;39(3):635-44.
2012: Pascale Rialland; Sylvain Bichot; Dominique Gauvin; Martin Guillot; Bertrand Lussier; Johanne Martel-Pelletier; Maxim Moreau; Jean-Pierre Pelletier; Eric Troncy
Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis.
BMC veterinary research 2012;8():162.
2012: Maxim Moreau; Jean-Pierre Pelletier; Christian Bédard; Dominique Gauvin; Bertrand Lussier; Johanne Martel-Pelletier; Eric Troncy
Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():646191.
2012: Sarah-Salwa Nebbaki; Jean-Pierre Pelletier; Mohit Kapoor; Johanne Martel-Pelletier; Hassan Afif; Mohamed Benderdour; Nicolas Duval; Fatima Ezzahra El Mansouri; Hassan Fahmi
Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes.
Arthritis research & therapy 2012;14(2):R69.
2011: Élie Abed; Thomas F Chan; Aline Delalandre; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Daniel Lajeunesse
R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts.
Arthritis and rheumatism 2011;63(12):3865-75.
2011: Jean-Pierre Raynauld; Lukas M Wildi; François Abram; Denis Choquette; Marc Dorais; Boulos Haraoui; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation.
Annals of the rheumatic diseases 2011;70(8):1382-8.
2011: Nathalie Amiable; Johanne Martel-Pelletier; Bertrand Lussier; Steeve Kwan Tat; Jean-Pierre Pelletier; Christelle Boileau
Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradation.
The Journal of rheumatology 2011;38(5):911-20.
2011: Nadia Zayed; Fatima Ezzahra El Mansouri; Nadir Chabane; Mohit Kapoor; Johanne Martel-Pelletier; Mohamed Benderdour; Jean-Pierre Pelletier; Nicolas Duval; Hassan Fahmi
Valproic acid suppresses interleukin-1ß-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1.
The Journal of rheumatology 2011;38(3):492-502.
2011: Maxim Moreau; Jean-Pierre Pelletier; Pascale Rialland; Dominique THIBAUD; Guy Beauchamp; Thierry Bertaim; Christelle Boileau; Judith Caron; Jerome R E del Castillo; Diane Frank; Dominique Gauvin; Daniel Lajeunesse; Bertrand Lussier; Johanne Martel-Pelletier; Eric Troncy
Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model.
Arthritis research & therapy 2011;13(3):R98.
2011: Mohit Kapoor; Johanne Martel-Pelletier; Daniel Lajeunesse; Jean-Pierre Pelletier; Hassan Fahmi
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis.
Nature reviews. Rheumatology 2011;7(1):33-42.
2011: Jean-Pierre Pelletier; Eric Troncy; Thierry Bertaim; Dominique THIBAUD; Anne-Christine Goulet; François Abram; Judith Caron; Christelle Boileau; Marc-André d'Anjou; Maxim Moreau; Bertrand Lussier; Johanne Martel-Pelletier
Treatment with tiludronic acid helps reduce the development of experimental osteoarthritis lesions in dogs with anterior cruciate ligament transection followed by reconstructive surgery: a 1-year study with quantitative magnetic resonance imaging.
The Journal of rheumatology 2011;38(1):118-28.
2010: Jean-Pierre Raynauld; Johanne Martel-Pelletier; André Beaulieu; Louis Bessette; Frédéric Morin; Denis Choquette; Boulos Haraoui; François Abram; Jean-Pierre Pelletier
An open-label pilot study evaluating by magnetic resonance imaging the potential for a disease-modifying effect of celecoxib compared to a modelized historical control cohort in the treatment of knee osteoarthritis.
Seminars in arthritis and rheumatism 2010;40(3):185-92.
2010: Johanne Martel-Pelletier; S Kwan Tat; Jean-Pierre Pelletier
Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18 Suppl 1():S7-11.
2010: Steeve Kwan Tat; Jean-Pierre Pelletier; François Mineau; Nicolas Duval; Johanne Martel-Pelletier
Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process.
The Journal of rheumatology 2010;37(3):656-64.
2010: Steeve Kwan Tat; Daniel Lajeunesse; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Targeting subchondral bone for treating osteoarthritis: what is the evidence?
Best practice & research. Clinical rheumatology 2010;24(1):51-70.
2010: Jean-Pierre Pelletier; Marc C Hochberg; Patrick Du Souich; André Kahan; Beat A Michel
Glucosamine and osteoarthritis. Effect size is encouraging.
BMJ (Clinical research ed.) 2010;341():c6328.
2009: Steeve Kwan Tat; Nathalie Amiable; Jean-Pierre Pelletier; Christelle Boileau; Daniel Lajeunesse; Nicolas Duval; Johanne Martel-Pelletier
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.
Rheumatology (Oxford, England) 2009;48(12):1482-90.
2009: Johanne Martel-Pelletier; Jean-Pierre Pelletier
Osteoarthritis: A single injection of anakinra for treating knee OA?
Nature reviews. Rheumatology 2009;5(7):363-4.
2009: Nathalie Amiable; Steeve Kwan Tat; Daniel Lajeunesse; Nicolas Duval; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Christelle Boileau
Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Bone 2009;44(6):1143-50.
2009: Jean-Pierre Raynauld; Johanne Martel-Pelletier; P Bias; Stefan Laufer; Boulos Haraoui; Denis Choquette; André Beaulieu; F Abram; Marc Dorais; E Vignon; Jean-Pierre Pelletier
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.
Annals of the rheumatic diseases 2009;68(6):938-47.
2009: Zhiyong FAN; Ginette Tardif; David Hum; Nicolas Duval; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Hsp90{beta} and p130(cas): novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes.
Annals of the rheumatic diseases 2009;68(6):976-82.
2009: Denis Couchourel; Isabelle Aubry; Aline Delalandre; Martin Lavigne; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Daniel Lajeunesse
Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production.
Arthritis and rheumatism 2009;60(5):1438-50.
2009: Steeve Kwan Tat; Jean-Pierre Pelletier; Carmen Ruiz Velasco; Marc Padrines; Johanne Martel-Pelletier
New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?
The Keio journal of medicine 2009;58(1):29-40.
2009: Jean-Pierre Pelletier; Johanne Martel-Pelletier
Imaging in osteoarthritis trials: useful or just expensive?
Nature clinical practice. Rheumatology 2009;5(2):76-7.
2009: Ginette Tardif; Jean-Pierre Pelletier; Christelle Boileau; Johanne Martel-Pelletier
The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(2):263-70.
2009: Ginette Tardif; David Hum; Jean-Pierre Pelletier; Nicolas Duval; Johanne Martel-Pelletier
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.
BMC musculoskeletal disorders 2009;10():148.
2009: Steeve Kwan Tat; Jean-Pierre Pelletier; Nathalie Amiable; Christelle Boileau; Martin Lavigne; Johanne Martel-Pelletier
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.
Arthritis research & therapy 2009;11(4):R119.
2009: Nadir Chabane; Nadia Zayed; Mohamed Benderdour; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Hassan Fahmi
Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.
Arthritis research & therapy 2009;11(2):R44.
2009: Christelle Boileau; Johanne Martel-Pelletier; Judith Caron; Philippe Msika; Georges B Guillou; Caroline Baudouin; Jean-Pierre Pelletier
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Arthritis research & therapy 2009;11(2):R41.
2008: Steeve Kwan Tat; Jean-Pierre Pelletier; Nathalie Amiable; Christelle Boileau; Daniel Lajeunesse; Nicolas Duval; Johanne Martel-Pelletier
Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
Arthritis and rheumatism 2008;58(12):3820-30.
2008: Nadia Zayed; Hassan Afif; Nadir Chabane; Leandra Mfuna-Endam; Mohamed Benderdour; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Rajender K Motiani; Mohamed Trebak; Nicolas Duval; Hassan Fahmi
Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.
Arthritis and rheumatism 2008;58(11):3530-40.
2008: Marc-André d'Anjou; Eric Troncy; Maxim Moreau; F Abram; Jean-Pierre Raynauld; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(11):1307-11.
2008: N Chabane; N Zayed; Hassan Afif; L Mfuna-Endam; Mohamed Benderdour; Christelle Boileau; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Hassan Fahmi
Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(10):1267-74.
2008: Steeve Kwan Tat; Jean-Pierre Pelletier; Daniel Lajeunesse; Hassan Fahmi; Nicolas Duval; Johanne Martel-Pelletier
Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.
Bone 2008;43(2):284-91.
2008: Christelle Boileau; Johanne Martel-Pelletier; F Abram; Jean-Pierre Raynauld; Eric Troncy; Marc-André d'Anjou; Maxim Moreau; Jean-Pierre Pelletier
Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis.
Annals of the rheumatic diseases 2008;67(7):926-32.
2008: Jean-Pierre Raynauld; Johanne Martel-Pelletier; Marie-Josée Berthiaume; F Abram; Denis Choquette; Boulos Haraoui; John F Beary; Gary A Cline; Joan M Meyer; Jean-Pierre Pelletier
Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period.
Annals of the rheumatic diseases 2008;67(5):683-8.
2008: Johanne Martel-Pelletier; Christelle Boileau; Jean-Pierre Pelletier; Peter J Roughley
Cartilage in normal and osteoarthritis conditions.
Best practice & research. Clinical rheumatology 2008;22(2):351-84.
2008: S Kwan Tat; Jean-Pierre Pelletier; Daniel Lajeunesse; Hassan Fahmi; Martin Lavigne; Johanne Martel-Pelletier
The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells.
Clinical and experimental rheumatology 2008;26(2):295-304.
2008: Marc-André d'Anjou; Maxim Moreau; Eric Troncy; Johanne Martel-Pelletier; François Abram; Jean-Pierre Raynauld; Jean-Pierre Pelletier
Osteophytosis, subchondral bone sclerosis, joint effusion and soft tissue thickening in canine experimental stifle osteoarthritis: comparison between 1.5 T magnetic resonance imaging and computed radiography.
Veterinary surgery : VS 2008;37(2):166-77.
2008: Christelle Boileau; F Poirier; Jean-Pierre Pelletier; Mélanie Guévremont; Nicolas Duval; Johanne Martel-Pelletier; Pascal Reboul
Intracellular localisation of galectin-3 has a protective role in chondrocyte survival.
Annals of the rheumatic diseases 2008;67(2):175-81.
2008: Nadia Zayed; Xinfang Li; Nadir Chabane; Mohamed Benderdour; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Hassan Fahmi
Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.
Arthritis research & therapy 2008;10(6):R146.
2008: Jean-Pierre Raynauld; Johanne Martel-Pelletier; François Abram; Marc Dorais; Boulos Haraoui; Denis Choquette; Peter Bias; Karl H Emmert; Stefan Laufer; Jean-Pierre Pelletier
Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.
Arthritis research & therapy 2008;10(6):R129.
2008: Jean-Pierre Pelletier; Jean-Pierre Raynauld; F Abram; Boulos Haraoui; Denis Choquette; Johanne Martel-Pelletier
A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16 Suppl 3():S8-13.
2008: Christelle Boileau; Steeve Kwan Tat; Jean-Pierre Pelletier; Saranette Cheng; Johanne Martel-Pelletier
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
Arthritis research & therapy 2008;10(3):R71.
2007: Boulos Haraoui; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Immunogenicity of biologic agents: a new concern for the practicing rheumatologist?
Current rheumatology reports 2007;9(4):265-7.
2007: Christelle Boileau; Johanne Martel-Pelletier; Hassan Fahmi; François Mineau; Martin Boily; Jean-Pierre Pelletier
The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways.
Arthritis and rheumatism 2007;56(7):2288-98.
2007: Christelle Boileau; Nathalie Amiable; Johanne Martel-Pelletier; Hassan Fahmi; Nicolas Duval; Jean-Pierre Pelletier
Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study.
Arthritis research & therapy 2007;9(6):R121.
2007: Steeve Kwan Tat; Jean-Pierre Pelletier; Josep Vergés; Daniel Lajeunesse; Eulàlia Montell; Hassan Fahmi; Martin Lavigne; Johanne Martel-Pelletier
Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study.
Arthritis research & therapy 2007;9(6):R117.
2007: Jean-Pierre Pelletier; Johanne Martel-Pelletier
DMOAD developments: present and future.
Bulletin of the NYU hospital for joint diseases 2007;65(3):242-8.
2007: Jean-Pierre Pelletier; Jean-Pierre Raynauld; Marie-Josée Berthiaume; François Abram; Denis Choquette; Boulos Haraoui; John F Beary; Gary A Cline; Joan M Meyer; Johanne Martel-Pelletier
Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study.
Arthritis research & therapy 2007;9(4):R74.
2007: Hassan Afif; Mohamed Benderdour; Leandra Mfuna-Endam; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Hassan Fahmi
Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1beta in articular chondrocytes.
Arthritis research & therapy 2007;9(2):R31.
2007: Audrée Janelle-Montcalm; Christelle Boileau; Françoise Poirier; Jean-Pierre Pelletier; Mélanie Guévremont; Nicolas Duval; Johanne Martel-Pelletier; Pascal Reboul
Extracellular localization of galectin-3 has a deleterious role in joint tissues.
Arthritis research & therapy 2007;9(1):R20.
2006: Clifton O Bingham; J Chris Buckland-Wright; Patrick Garnero; Stanley B Cohen; Maxime Dougados; Silvano Adami; Daniel J Clauw; Tim D Spector; Jean-Pierre Pelletier; Jean-Pierre Raynauld; Vibeke Strand; Lee S Simon; Joan M Meyer; Gary A Cline; John F Beary
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study.
Arthritis and rheumatism 2006;54(11):3494-507.
2006: Saranette Cheng; Hassan Afif; Johanne Martel-Pelletier; Mohamed Benderdour; Jean-Pierre Pelletier; G Hilal; P Haraoui; Jean-Pierre Raynauld; Denis Choquette; Hassan Fahmi
Association of polymorphisms in the peroxisome proliferator-activated receptor gamma gene and osteoarthritis of the knee.
Annals of the rheumatic diseases 2006;65(10):1394-7.
2006: Zhiyong FAN; Ginette Tardif; Christelle Boileau; Joseph P Bidwell; Changshan Geng; David Hum; Alexander Watson; Jean-Pierre Pelletier; Martin Lavigne; Johanne Martel-Pelletier
Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter.
Arthritis and rheumatism 2006;54(8):2471-80.
2006: Maxim Moreau; Christelle Boileau; Johanne Martel-Pelletier; Julie Brunet; Stefan Laufer; Jean-Pierre Pelletier
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
The Journal of rheumatology 2006;33(6):1176-83.
2006: Christelle Boileau; Johanne Martel-Pelletier; Julie Brunet; Denis Schrier; Craig Flory; Martin Boily; Jean-Pierre Pelletier
PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect.
Annals of the rheumatic diseases 2006;65(5):573-80.
2006: Emmanuel Maheu; Roy D Altman; DA Bloch; Michael Doherty; Marc C Hochberg; A Mannoni; Leonardo Punzi; Tim D Spector; G Verbruggen; A Carr; F Cicuttini; Renèe-Liliane Dreiser; Boulos Haraoui; D Hart; Jean-Pierre Pelletier; Roberta Ramonda; L Rovati
Design and conduct of clinical trials in patients with osteoarthritis of the hand: recommendations from a task force of the Osteoarthritis Research Society International.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(4):303-22.
2006: Frédéric Massicotte; Julio C Fernandes; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Daniel Lajeunesse
Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts.
Bone 2006;38(3):333-41.
2006: Johanne Martel-Pelletier; Daniel Lajeunesse; Hassan Fahmi; Ginette Tardif; Jean-Pierre Pelletier
New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.
Current rheumatology reports 2006;8(1):30-6.
2006: Ginette Tardif; Jean-Pierre Pelletier; David Hum; Christelle Boileau; Nicolas Duval; Johanne Martel-Pelletier
Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes.
Annals of the rheumatic diseases 2006;65(2):261-4.
2006: Kelitha Maxis; Aline Delalandre; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Daniel Lajeunesse
The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.
Arthritis research & therapy 2006;8(6):R181.
2006: Frédéric Massicotte; Isabelle Aubry; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Julio Fernandes; Daniel Lajeunesse
Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts.
Arthritis research & therapy 2006;8(6):R177.
2006: Jean-Pierre Pelletier; Johanne Martel-Pelletier; Jean-Pierre Raynauld
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.
Arthritis research & therapy 2006;8(2):206.
2006: Jordi Monfort; Ginette Tardif; Pascal Reboul; François Mineau; Peter J Roughley; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
Arthritis research & therapy 2006;8(1):R26.
2006: Jean-Pierre Raynauld; Johanne Martel-Pelletier; Marie-Josée Berthiaume; Gilles Beaudoin; Denis Choquette; Boulos Haraoui; Hyman Tannenbaum; Joan M Meyer; John F Beary; Gary A Cline; Jean-Pierre Pelletier
Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes.
Arthritis research & therapy 2006;8(1):R21.
2005: Jean-Pierre Pelletier; Johanne Martel-Pelletier
New trends in the treatment of osteoarthritis.
Seminars in arthritis and rheumatism 2005;34(6 Suppl 2):13-4.
2005: Johanne Martel-Pelletier; Jean-Pierre Pelletier
New insights into the major pathophysiological processes responsible for the development of osteoarthritis.
Seminars in arthritis and rheumatism 2005;34(6 Suppl 2):6-8.
2005: Christelle Boileau; Jean-Pierre Pelletier; Ginette Tardif; Hassan Fahmi; Stefan Laufer; Martin Lavigne; Johanne Martel-Pelletier
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Annals of the rheumatic diseases 2005;64(6):891-8.
2005: Xinfang Li; Hassan Afif; Saranette Cheng; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Pierre Ranger; Hassan Fahmi
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.
The Journal of rheumatology 2005;32(5):887-95.
2005: Patrick Marcouiller; Jean-Pierre Pelletier; Mélanie Guévremont; Johanne Martel-Pelletier; Pierre Ranger; Stefan Laufer; Pascal Reboul
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
The Journal of rheumatology 2005;32(4):704-12.
2005: Patrick Lavigne; Mohamed Benderdour; Daniel Lajeunesse; Pascal Reboul; Qin Shi; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Julio C Fernandes
Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(4):310-7.
2005: Daniel Lajeunesse; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Osteoarthritis: a metabolic disease induced by local abnormal leptin activity?
Current rheumatology reports 2005;7(2):79-81.
2005: Marie-Josée Berthiaume; Jean-Pierre Raynauld; Johanne Martel-Pelletier; F Labonté; Gilles Beaudoin; D A Bloch; Denis Choquette; Boulos Haraoui; Roy D Altman; Marc C Hochberg; Joan M Meyer; Gary A Cline; Jean-Pierre Pelletier
Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging.
Annals of the rheumatic diseases 2005;64(4):556-63.
2005: M Moreau; S Daminet; Johanne Martel-Pelletier; J Fernandes; Jean-Pierre Pelletier
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs.
Journal of veterinary pharmacology and therapeutics 2005;28(1):81-6.
2005: Christelle Boileau; Johanne Martel-Pelletier; Julie Brunet; Ginette Tardif; Denis Schrier; Craig Flory; Ayman El-Kattan; Martin Boily; Jean-Pierre Pelletier
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Arthritis and rheumatism 2005;52(2):488-500.
2005: Jean-Pierre Pelletier; Christelle Boileau; Martin Boily; Julie Brunet; François Mineau; Changshan Geng; Pascal Reboul; Stefan Laufer; Daniel Lajeunesse; Johanne Martel-Pelletier
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Arthritis research & therapy 2005;7(5):R1091-102.
2005: Christina Alexandra Manacu; Johanne Martel-Pelletier; Marjolaine Roy-Beaudry; Jean-Pierre Pelletier; Julio C Fernandes; Fazool S Shipkolye; Dragoslav R Mitrovic; Florina Moldovan
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.
Arthritis research & therapy 2005;7(2):R324-32.
2005: Katherine Farrajota; Saranette Cheng; Johanne Martel-Pelletier; Hassan Afif; Jean-Pierre Pelletier; Xinfang Li; Pierre Ranger; Hassan Fahmi
Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.
Arthritis and rheumatism 2005;52(1):94-104.
2004: Johanne Martel-Pelletier; François Mineau; Hassan Fahmi; Stefan Laufer; Pascal Reboul; Christelle Boileau; Martin Lavigne; Jean-Pierre Pelletier
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Arthritis and rheumatism 2004;50(12):3925-33.
2004: Ginette Tardif; David Hum; Jean-Pierre Pelletier; Christelle Boileau; Pierre Ranger; Johanne Martel-Pelletier
Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
Arthritis and rheumatism 2004;50(8):2521-30.
2004: Mélanie Guévremont; Johanne Martel-Pelletier; Christelle Boileau; Fu-Tong Liu; M Richard; Julio C Fernandes; Jean-Pierre Pelletier; Pascal Reboul
Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3.
Annals of the rheumatic diseases 2004;63(6):636-43.
2004: Saranette Cheng; Hassan Afif; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Xinfang Li; Katherine Farrajota; Martin Lavigne; Hassan Fahmi
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
The Journal of biological chemistry 2004;279(21):22057-65.
2004: Jean-Pierre Pelletier; Christelle Boileau; Julie Brunet; Martin Boily; Daniel Lajeunesse; Pascal Reboul; Stefan Laufer; Johanne Martel-Pelletier
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Bone 2004;34(3):527-38.
2004: Jean-Pierre Raynauld; Johanne Martel-Pelletier; Marie-Josée Berthiaume; Françoys Labonté; Gilles Beaudoin; Jacques A de Guise; Daniel A Bloch; Denis Choquette; Boulos Haraoui; Roy D Altman; Marc C Hochberg; Joan M Meyer; Gary A Cline; Jean-Pierre Pelletier
Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes.
Arthritis and rheumatism 2004;50(2):476-87.
2004: Ginette Tardif; Pascal Reboul; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3).
Modern rheumatology / the Japan Rheumatism Association 2004;14(3):197-204.
2004: Jean-Pierre Pelletier
Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12 Suppl A():S63-8.
2004: Daniel Lajeunesse; Johanne Martel-Pelletier; Julio C Fernandes; Stefan Laufer; Jean-Pierre Pelletier
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Annals of the rheumatic diseases 2004;63(1):78-83.
2003: Johanne Martel-Pelletier; Jean-Pierre Pelletier; Hassan Fahmi
Cyclooxygenase-2 and prostaglandins in articular tissues.
Seminars in arthritis and rheumatism 2003;33(3):155-67.
2003: Jean-Pierre Pelletier; Johanne Martel-Pelletier
Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii79-82.
2003: Marjolaine Roy-Beaudry; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Khatija Nait M'Barek; Stephan Christgau; Fazool Shipkolye; Florina Moldovan
Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction.
Arthritis and rheumatism 2003;48(10):2855-64.
2003: Daniel Lajeunesse; Aline Delalandre; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts.
Bone 2003;33(4):703-10.
2003: Claude Kauffmann; Pierre Gravel; Benoit Godbout; Alain Gravel; Gilles Beaudoin; Jean-Pierre Raynauld; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Jacques A de Guise
Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model.
IEEE transactions on bio-medical engineering 2003;50(8):978-88.
2003: Ginette Tardif; Martine Dupuis; Pascal Reboul; Changshan Geng; Jean-Pierre Pelletier; Pierre Ranger; Johanne Martel-Pelletier
Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(7):524-37.
2003: Mélanie Guévremont; Johanne Martel-Pelletier; Frédéric Massicotte; Ginette Tardif; Jean-Pierre Pelletier; Pierre Ranger; Daniel Lajeunesse; Pascal Reboul
Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(6):1073-81.
2003: Jean-Pierre Pelletier; Julio C Fernandes; Julie Brunet; Florina Moldovan; Denis Schrier; Craig Flory; Johanne Martel-Pelletier
In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes.
Arthritis and rheumatism 2003;48(6):1582-93.
2003: Johanne Martel-Pelletier; Daniel Lajeunesse; Pascal Reboul; Jean-Pierre Pelletier
Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.
Annals of the rheumatic diseases 2003;62(6):501-9.
2003: Jean-Pierre Raynauld; Claude Kauffmann; Gilles Beaudoin; Marie-Josée Berthiaume; Jacques A de Guise; DA Bloch; F Camacho; Benoit Godbout; Roy D Altman; Marc C Hochberg; J M Meyer; G Cline; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(5):351-60.
2003: Jean-Pierre Pelletier; François Mineau; Christelle Boileau; Johanne Martel-Pelletier
Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.
Clinical and experimental rheumatology 2003;21(2):171-7.
2003: Jean-Pierre Raynauld; Chris Buckland-Wright; Rupert Ward; Denis Choquette; Boulos Haraoui; Johanne Martel-Pelletier; Imad Uthman; Visithan Khy; Jean-Luc Tremblay; Carole Bertrand; Jean-Pierre Pelletier
Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2003;48(2):370-7.
2002: Sandrine Pacquelet; Nathalie Presle; Christelle Boileau; Hélène Dumond; Patrick Netter; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Bernard Terlain; Jean-Yves Jouzeau
Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis.
The Journal of rheumatology 2002;29(12):2602-10.
2002: Patrick Lavigne; Qin Shi; Francine Jolicoeur; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Julio C Fernandes
Modulation of IL-1beta, IL-6, TNF-alpha and PGE(2) by pharmacological agents in explants of membranes from failed total hip replacement.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(11):898-904.
2002: Hassan Fahmi; Jean-Pierre Pelletier; François Mineau; Johanne Martel-Pelletier
15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(11):845-8.
2002: Christelle Boileau; Johanne Martel-Pelletier; Florina Moldovan; Jean-Yves Jouzeau; Patrick Netter; Pamela T Manning; Jean-Pierre Pelletier
The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide.
Arthritis and rheumatism 2002;46(10):2637-47.
2002: Dragan V Jovanovic; François Mineau; Kohei Notoya; Pascal Reboul; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.
The Journal of rheumatology 2002;29(10):2165-75.
2002: Christelle Boileau; Johanne Martel-Pelletier; Jean-Yves Jouzeau; Patrick Netter; Florina Moldovan; Stefan Laufer; Susanne Tries; Jean-Pierre Pelletier
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
The Journal of rheumatology 2002;29(7):1446-53.
2002: Qin Shi; Daniel Lajeunesse; Pascal Reboul; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Faramaze Dehnade; Julio C Fernandes
Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening.
The Journal of rheumatology 2002;29(7):1437-45.
2002: Yosabeth Paredes; Frédéric Massicotte; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Stefan Laufer; Daniel Lajeunesse
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Arthritis and rheumatism 2002;46(7):1804-12.
2002: Mohamed Benderdour; Ginette Tardif; Jean-Pierre Pelletier; John A Di Battista; Pascal Reboul; Pierre Ranger; Johanne Martel-Pelletier
Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta.
The Journal of rheumatology 2002;29(6):1262-72.
2002: Frédéric Massicotte; Daniel Lajeunesse; Mohamed Benderdour; Jean-Pierre Pelletier; G Hilal; Nicolas Duval; Johanne Martel-Pelletier
Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(6):491-500.
2002: Mohamed Benderdour; Ginette Tardif; Jean-Pierre Pelletier; Martine Dupuis; Changshan Geng; Johanne Martel-Pelletier
A novel negative regulatory element in the human collagenase-3 proximal promoter region.
Biochemical and biophysical research communications 2002;291(5):1151-9.
2002: Wendy He; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Stefan Laufer; John A Di Battista
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
The Journal of rheumatology 2002;29(3):546-53.
2002: Hassan Fahmi; Jean-Pierre Pelletier; John A Di Battista; Herman S Cheung; Julio C Fernandes; Johanne Martel-Pelletier
Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(2):100-8.
2002: Tanja Kalajdzic; Wissam H Faour; Qing Wen He; Hassan Fahmi; Johanne Martel-Pelletier; Jean-Pierre Pelletier; John A Di Battista
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
Arthritis and rheumatism 2002;46(2):494-506.
2002: Julio C Fernandes; Johanne Martel-Pelletier; Jean-Pierre Pelletier
The role of cytokines in osteoarthritis pathophysiology.
Biorheology 2002;39(1-2):237-46.
2002: Jean-Pierre Pelletier; Johanne Martel-Pelletier
The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man.
Arthritis research 2002;4(1):13-9.
2001: Johanne Martel-Pelletier; Jean-Pierre Raynauld; Jean-Pierre Pelletier
Quantitative imaging of the structural changes of osteoarthritis: an exciting challenge for the new millennium.
Current rheumatology reports 2001;3(6):465-6.
2001: Jean-Pierre Pelletier; Julio C Fernandes; Dragan V Jovanovic; Pascal Reboul; Johanne Martel-Pelletier
Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.
The Journal of rheumatology 2001;28(11):2509-19.
2001: Dragan V Jovanovic; Julio C Fernandes; Johanne Martel-Pelletier; Francine Jolicoeur; Pascal Reboul; Stefan Laufer; Susanne Tries; Jean-Pierre Pelletier
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Arthritis and rheumatism 2001;44(10):2320-30.
2001: Ginette Tardif; Pascal Reboul; Martine Dupuis; Changshan Geng; Nicolas Duval; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites.
The Journal of rheumatology 2001;28(7):1631-9.
2001: Jean-Pierre Pelletier; Johanne Martel-Pelletier; S B Abramson
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.
Arthritis and rheumatism 2001;44(6):1237-47.
2001: Hassan Fahmi; Y He; M Zhang; Johanne Martel-Pelletier; Jean-Pierre Pelletier; John A Di Battista
Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(4):332-40.
2001: Jean-Pierre Pelletier; Daniel Lajeunesse; Pascal Reboul; François Mineau; Julio C Fernandes; P Sabouret; Johanne Martel-Pelletier
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
The Journal of rheumatology 2001;28(4):814-24.
2001: Dragan V Jovanovic; John A Di Battista; Johanne Martel-Pelletier; Pascal Reboul; Y He; Francine Jolicoeur; Jean-Pierre Pelletier
Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages.
The Journal of rheumatology 2001;28(4):712-8.
2001: G Hilal; Frédéric Massicotte; Johanne Martel-Pelletier; Julio C Fernandes; Jean-Pierre Pelletier; Daniel Lajeunesse
Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):713-21.
2001: Hassan Fahmi; John A Di Battista; Jean-Pierre Pelletier; François Mineau; Pierre Ranger; Johanne Martel-Pelletier
Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes.
Arthritis and rheumatism 2001;44(3):595-607.
2001: John A Di Battista; Hassan Fahmi; Y He; M Zhang; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Clinical and experimental rheumatology 2001;19(1 Suppl 22):S3-5.
2001: Pascal Reboul; Jean-Pierre Pelletier; Ginette Tardif; Mohamed Benderdour; Pierre Ranger; Donald Bottaro; Johanne Martel-Pelletier
Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade.
Arthritis and rheumatism 2001;44(1):73-84.
2000: Jean-Pierre Pelletier; Daniel Lajeunesse; Dragan V Jovanovic; V Lascau-Coman; Francine Jolicoeur; G Hilal; Julio C Fernandes; Johanne Martel-Pelletier
Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis.
The Journal of rheumatology 2000;27(12):2893-902.
2000: Jean-Pierre Pelletier; Michael Yaron; Boulos Haraoui; P Cohen; M A Nahir; Denis Choquette; Irena Wigler; I A Rosner; André Beaulieu
Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group.
Arthritis and rheumatism 2000;43(10):2339-48.
2000: K Notoya; Dragan V Jovanovic; Pascal Reboul; Johanne Martel-Pelletier; François Mineau; Jean-Pierre Pelletier
The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3402-10.
2000: Florina Moldovan; Jean-Pierre Pelletier; François Mineau; Martine Dupuis; Jonathan Cloutier; Johanne Martel-Pelletier
Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase.
Arthritis and rheumatism 2000;43(9):2100-9.
2000: Jean-Pierre Pelletier; Dragan V Jovanovic; V Lascau-Coman; Julio C Fernandes; Pamela T Manning; JR Connor; Mark G Currie; Johanne Martel-Pelletier
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level.
Arthritis and rheumatism 2000;43(6):1290-9.
2000: Dragan V Jovanovic; Johanne Martel-Pelletier; John A Di Battista; François Mineau; Francine Jolicoeur; Mohamed Benderdour; Jean-Pierre Pelletier
Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(5):1134-44.
2000: Florina Moldovan; Jean-Pierre Pelletier; Francine Jolicoeur; Jonathan Cloutier; Johanne Martel-Pelletier
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):186-96.
1999: Nada Alaaeddine; John A Di Battista; Jean-Pierre Pelletier; K Kiansa; Jonathan Cloutier; Johanne Martel-Pelletier
Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts.
Cytokine 1999;11(12):1020-30.
1999: M Zhang; C Miller; Y He; Johanne Martel-Pelletier; Jean-Pierre Pelletier; John A Di Battista
Calphostin C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein kinase C-alpha inhibition: possible role for c-jun N-terminal kinase.
Journal of cellular biochemistry 1999;76(2):290-302.
1999: Johanne Martel-Pelletier; François Mineau; Dragan Jovanovic; John A Di Battista; Jean-Pierre Pelletier
Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated proten kinase (MAPKAPK).
Arthritis and rheumatism 1999;42(11):2399-409.
1999: Johanne Martel-Pelletier; Nada Alaaeddine; Jean-Pierre Pelletier
Cytokines and their role in the pathophysiology of osteoarthritis.
Frontiers in bioscience : a journal and virtual library 1999;4():D694-703.
1999: Jean-Pierre Pelletier; Denis Choquette; Boulos Haraoui; Jean-Pierre Raynauld; E Rich; Julio C Fernandes; Johanne Martel-Pelletier
Pharmacologic therapy of osteoarthritis.
Current rheumatology reports 1999;1(1):54-8.
1999: G Hilal; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Daniel Lajeunesse
Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts.
Arthritis and rheumatism 1999;42(10):2112-22.
1999: Jean-Pierre Pelletier; V Lascau-Coman; Dragan Jovanovic; Julio C Fernandes; P Manning; JR Connor; Mark G Currie; Johanne Martel-Pelletier
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
The Journal of rheumatology 1999;26(9):2002-14.
1999: N Saha; Florina Moldovan; Ginette Tardif; Jean-Pierre Pelletier; Jonathan Cloutier; Johanne Martel-Pelletier
Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1beta and interleukin-18.
Arthritis and rheumatism 1999;42(8):1577-87.
1999: Jean-Pierre Pelletier
The influence of tissue cross-talking on OA progression: role of nonsteroidal antiinflammatory drugs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(4):374-6.
1999: Ginette Tardif; Jean-Pierre Pelletier; Martine Dupuis; Changshan Geng; Jonathan Cloutier; Johanne Martel-Pelletier
Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells.
Arthritis and rheumatism 1999;42(6):1147-58.
1999: Jean-Pierre Pelletier; John A Di Battista; M Zhang; J Fernandes; Nada Alaaeddine; Johanne Martel-Pelletier
Effect of nimesulide on glucocorticoid receptor activity in human synovial fibroblasts.
Rheumatology (Oxford, England) 1999;38 Suppl 1():11-3.
1999: Jean-Pierre Pelletier
Pathophysiological targets in OA therapy.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):353-4.
1999: Jean-Pierre Pelletier; Daniel Lajeunesse; G Hilal; Dragan Jovanovic; Julio C Fernandes; Johanne Martel-Pelletier
Carprofen reduces the structural changes and the abnormal subchondral bone metabolism of experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):327-8.
1999: Daniel Lajeunesse; G Hilal; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Subchondral bone morphological and biochemical alterations in osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):321-2.
1999: Jean-Pierre Pelletier; J Y Reginster
The influence of tissular cross-talking on osteoarthritis progression: role of nonsteroidal antiinflammatory drugs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):306-7.
1999: J Fernandes; Ginette Tardif; Johanne Martel-Pelletier; V Lascau-Coman; Martine Dupuis; Florina Moldovan; M Sheppard; B R Krishnan; Jean-Pierre Pelletier
In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression.
The American journal of pathology 1999;154(4):1159-69.
1999: Nada Alaaeddine; John A Di Battista; Jean-Pierre Pelletier; K Kiansa; Jonathan Cloutier; Johanne Martel-Pelletier
Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways.
Arthritis and rheumatism 1999;42(4):710-8.
1999: S Su; J Grover; P J Roughley; JA DiBattista; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Muhammad Zafarullah
Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints.
Rheumatology international 1999;18(5-6):183-91.
1999: John A Di Battista; M Zhang; Johanne Martel-Pelletier; J Fernandes; Nada Alaaeddine; Jean-Pierre Pelletier
Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor.
Arthritis and rheumatism 1999;42(1):157-66.
1998: Jean-Pierre Pelletier; François Mineau; Julio C Fernandes; Nicolas Duval; Johanne Martel-Pelletier
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
The Journal of rheumatology 1998;25(12):2417-24.
1998: Julio C Fernandes; Johanne Martel-Pelletier; V Lascau-Coman; Florina Moldovan; Dragan Jovanovic; Jean-Pierre Raynauld; Jean-Pierre Pelletier
Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: an immunohistochemical study.
The Journal of rheumatology 1998;25(8):1585-94.
1998: Jean-Pierre Pelletier; Dragan Jovanovic; Julio C Fernandes; P Manning; JR Connor; Mark G Currie; John A Di Battista; Johanne Martel-Pelletier
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.
Arthritis and rheumatism 1998;41(7):1275-86.
1998: C Miller; M Zhang; Y He; J Zhao; Jean-Pierre Pelletier; Johanne Martel-Pelletier; John A Di Battista
Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins.
Journal of cellular biochemistry 1998;69(4):392-413.
1998: Julio C Fernandes; Johanne Martel-Pelletier; Dragan Jovanovic; Ginette Tardif; JA DiBattista; V Lascau-Coman; I G Otterness; Jean-Pierre Pelletier
The effects of tenidap on canine experimental osteoarthritis: II. Study of the expression of collagenase-1 and interleukin 1beta by in situ hybridization.
The Journal of rheumatology 1998;25(5):951-8.
1998: G Hilal; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Pierre Ranger; Daniel Lajeunesse
Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis.
Arthritis and rheumatism 1998;41(5):891-9.
1998: Johanne Martel-Pelletier; François Mineau; Francine Jolicoeur; Jonathan Cloutier; Jean-Pierre Pelletier
In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.
The Journal of rheumatology 1998;25(4):753-62.
1998: Dragan V Jovanovic; John A Di Battista; Johanne Martel-Pelletier; Francine Jolicoeur; Y He; M Zhang; François Mineau; Jean-Pierre Pelletier
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3513-21.
1998: Julio C Fernandes; D Jovanovic; Faramaze Dehnade; Johanne Martel-Pelletier; Jean-Pierre Pelletier
[Resection of the anterior cruciate ligament of the knee using arthroscopy induces arthrosis in dogs. Validity of the Pond-Nuki model].
Annales de chirurgie 1998;52(8):768-75.
1998: Dragan Jovanovic; Jean-Pierre Pelletier; Nada Alaaeddine; François Mineau; Changshan Geng; Pierre Ranger; Johanne Martel-Pelletier
Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(1):40-9.
1997: Nada Alaaeddine; JA DiBattista; Jean-Pierre Pelletier; Jonathan Cloutier; K Kiansa; Martine Dupuis; Johanne Martel-Pelletier
Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha.
The Journal of rheumatology 1997;24(10):1985-94.
1997: Florina Moldovan; Jean-Pierre Pelletier; J Hambor; Jonathan Cloutier; Johanne Martel-Pelletier
Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta.
Arthritis and rheumatism 1997;40(9):1653-61.
1997: Jean-Pierre Pelletier; François Mineau; J Fernandes; K Kiansa; Pierre Ranger; Johanne Martel-Pelletier
Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.
Clinical and experimental rheumatology 1997;15(4):393-8.
1997: Jean-Pierre Pelletier; JP Caron; C Evans; P D Robbins; H I Georgescu; Dragan Jovanovic; Julio C Fernandes; Johanne Martel-Pelletier
In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy.
Arthritis and rheumatism 1997;40(6):1012-9.
1997: John A Di Battista; Sylvain Dore; N Morin; Y He; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Prostaglandin E2 stimulates insulin-like growth factor binding protein-4 expression and synthesis in cultured human articular chondrocytes: possible mediation by Ca(++)-calmodulin regulated processes.
Journal of cellular biochemistry 1997;65(3):408-19.
1997: Dragan Jovanovic; JP Caron; Johanne Martel-Pelletier; Julio C Fernandes; T Ricketts; Jean-Pierre Pelletier
The therapeutic effects of tenidap in canine experimental osteoarthritis: relationship with biochemical markers.
The Journal of rheumatology 1997;24(5):916-25.
1997: Ginette Tardif; Jean-Pierre Pelletier; Martine Dupuis; J E Hambor; Johanne Martel-Pelletier
Cloning, sequencing and characterization of the 5'-flanking region of the human collagenase-3 gene.
The Biochemical journal 1997;323 ( Pt 1)():13-6.
1997: Julio C Fernandes; JP Caron; Johanne Martel-Pelletier; Dragan Jovanovic; François Mineau; Ginette Tardif; I G Otterness; Jean-Pierre Pelletier
Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity.
Arthritis and rheumatism 1997;40(2):284-94.
1996: C Tavera; Thierry Abribat; P Reboul; Sylvain Dore; P Brazeau; Jean-Pierre Pelletier; Johanne Martel-Pelletier
IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1996;4(4):263-74.
1996: John P Caron; Ginette Tardif; Johanne Martel-Pelletier; JA DiBattista; Changshan Geng; Jean-Pierre Pelletier
Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids.
American journal of veterinary research 1996;57(11):1631-4.
1996: John A Di Battista; Sylvain Dore; Johanne Martel-Pelletier; Jean-Pierre Pelletier
Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I.
Molecular and cellular endocrinology 1996;123(1):27-35.
1996: John P Caron; Julio C Fernandes; Johanne Martel-Pelletier; Ginette Tardif; François Mineau; Changshan Geng; Jean-Pierre Pelletier
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression.
Arthritis and rheumatism 1996;39(9):1535-44.
1996: Ginette Tardif; P Reboul; Jean-Pierre Pelletier; Changshan Geng; Jonathan Cloutier; Johanne Martel-Pelletier
Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins.
Arthritis and rheumatism 1996;39(6):968-78.
1996: P Reboul; Jean-Pierre Pelletier; Ginette Tardif; Jonathan Cloutier; Johanne Martel-Pelletier
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.
The Journal of clinical investigation 1996;97(9):2011-9.
1996: Jean-Pierre Pelletier; François Mineau; Pierre Ranger; Ginette Tardif; Johanne Martel-Pelletier
The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1996;4(1):77-84.
1996: Muhammad Zafarullah; S Su; Johanne Martel-Pelletier; JA DiBattista; B G Costello; William Stetler-Stevenson; Jean-Pierre Pelletier
Tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA is constitutively expressed in bovine, human normal, and osteoarthritic articular chondrocytes.
Journal of cellular biochemistry 1996;60(2):211-7.
1996: Johanne Martel-Pelletier; François Mineau; Ginette Tardif; Julio C Fernandes; Pierre Ranger; L Loose; Jean-Pierre Pelletier
Tenidap reduces the level of interleukin 1 receptors and collagenase expression in human arthritic synovial fibroblasts.
The Journal of rheumatology 1996;23(1):24-31.
1996: H Ounissi-Benkalha; Jean-Pierre Pelletier; Ginette Tardif; François Mineau; Francine Jolicoeur; Pierre Ranger; Johanne Martel-Pelletier
In vitro effects of 2 antirheumatic drugs on the synthesis and expression of proinflammatory cytokines in synovial membranes from patients with rheumatoid arthritis.
The Journal of rheumatology 1996;23(1):16-23.
1995: Julio C Fernandes; Johanne Martel-Pelletier; I G Otterness; A Lopez-Anaya; François Mineau; Ginette Tardif; Jean-Pierre Pelletier
Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis.
Arthritis and rheumatism 1995;38(9):1290-303.
1995: M B Sadouk; Jean-Pierre Pelletier; Ginette Tardif; K Kiansa; Jonathan Cloutier; Johanne Martel-Pelletier
Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor.
Laboratory investigation; a journal of technical methods and pathology 1995;73(3):347-55.
1995: Jean-Pierre Pelletier; JA DiBattista; Jean-Pierre Raynauld; S Wilhelm; Johanne Martel-Pelletier
The in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1, and oncogene protein synthesis in experimental osteoarthritis.
Laboratory investigation; a journal of technical methods and pathology 1995;72(5):578-86.
1995: JA DiBattista; Jean-Pierre Pelletier; Muhammad Zafarullah; K Iwata; Johanne Martel-Pelletier
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
Journal of cellular biochemistry 1995;57(4):619-29.
1995: Sylvain Dore; Thierry Abribat; N Rousseau; P Brazeau; Ginette Tardif; JA DiBattista; Jonathan Cloutier; Jean-Pierre Pelletier; Johanne Martel-Pelletier
Increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes is not dependent on growth hormone action.
Arthritis and rheumatism 1995;38(3):413-9.
1995: JA DiBattista; Jean-Pierre Pelletier; Muhammad Zafarullah; N Fujimoto; K Obata; Johanne Martel-Pelletier
Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts.
The Journal of rheumatology. Supplement 1995;43():123-8.
1995: Johanne Martel-Pelletier; François Mineau; Francine Jolicoeur; Jean-Pierre Pelletier
Modulation of TNFSR55 and TNFSR75 by cytokines and growth factors in human synovial fibroblasts.
The Journal of rheumatology. Supplement 1995;43():115-9.
1995: Jean-Pierre Pelletier; R McCollum; Jonathan Cloutier; Johanne Martel-Pelletier
Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process.
The Journal of rheumatology. Supplement 1995;43():109-14.
1994: Jean-Pierre Pelletier; Johanne Martel-Pelletier
[Role of synovial inflammation, cytokines and IGF-1 in the physiopathology of osteoarthritis].
Revue du rhumatisme (Ed. française : 1993) 1994;61(9 Pt 2):103S-108S.
1994: Jean-Pierre Pelletier; JA DiBattista; Pierre Ranger; Johanne Martel-Pelletier
The reduced expression of glucocorticoid receptors in synovial cells induced by nonsteroidal antiinflammatory drugs can be reversed by prostaglandin E1 analog.
The Journal of rheumatology 1994;21(9):1748-52.
1994: JA DiBattista; Johanne Martel-Pelletier; N Fujimoto; K Obata; Muhammad Zafarullah; Jean-Pierre Pelletier
Prostaglandins E2 and E1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Mediation by cyclic-AMP signalling pathway.
Laboratory investigation; a journal of technical methods and pathology 1994;71(2):270-8.
1994: JA DiBattista; Johanne Martel-Pelletier; N Morin; F C Jolicoeur; Jean-Pierre Pelletier
Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1.
Molecular and cellular endocrinology 1994;103(1-2):139-48.
1994: Johanne Martel-Pelletier; R McCollum; N Fujimoto; K Obata; Jonathan Cloutier; Jean-Pierre Pelletier
Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis.
Laboratory investigation; a journal of technical methods and pathology 1994;70(6):807-15.
1994: B Haraoui; Eugene Thonar; Johanne Martel-Pelletier; J R Goulet; Jean-Pierre Raynauld; M Ouellet; Jean-Pierre Pelletier
Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographic staging.
The Journal of rheumatology 1994;21(5):813-7.
1994: Jean-Pierre Pelletier; François Mineau; Jean-Pierre Raynauld; J F Woessner; Z Gunja-Smith; Johanne Martel-Pelletier
Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis.
Arthritis and rheumatism 1994;37(3):414-23.
1994: Sylvain Dore; Jean-Pierre Pelletier; JA DiBattista; Ginette Tardif; P Brazeau; Johanne Martel-Pelletier
Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins.
Arthritis and rheumatism 1994;37(2):253-63.
1993: Jean-Pierre Pelletier; R McCollum; JA DiBattista; L D Loose; Jonathan Cloutier; Johanne Martel-Pelletier
Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs.
Arthritis and rheumatism 1993;36(11):1517-27.
1993: Jean-Pierre Pelletier; JA DiBattista; P Roughley; R McCollum; Johanne Martel-Pelletier
Cytokines and inflammation in cartilage degradation.
Rheumatic diseases clinics of North America 1993;19(3):545-68.
1993: Muhammad Zafarullah; Johanne Martel-Pelletier; Jonathan Cloutier; Lashitew Gedamu; Jean-Pierre Pelletier
Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1993;1(3):151-6.
1993: JA DiBattista; Johanne Martel-Pelletier; T Antakly; Ginette Tardif; Jonathan Cloutier; Jean-Pierre Pelletier
Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis.
The Journal of clinical endocrinology and metabolism 1993;76(5):1128-34.
1993: Muhammad Zafarullah; Jean-Pierre Pelletier; Jonathan Cloutier; Johanne Martel-Pelletier
Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia.
The Journal of rheumatology 1993;20(4):693-7.
1993: Johanne Martel-Pelletier; R McCollum; Jean-Pierre Pelletier
The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1.
Biochimica et biophysica acta 1993;1175(3):302-5.
1993: Jean-Pierre Pelletier; Jonathan Cloutier; Johanne Martel-Pelletier
In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes.
Agents and actions. Supplements 1993;39():181-93.
1993: Jean-Pierre Pelletier; M P Faure; JA DiBattista; S Wilhelm; D Visco; Johanne Martel-Pelletier
Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study.
The American journal of pathology 1993;142(1):95-105.
1993: Jean-Pierre Pelletier; Johanne Martel-Pelletier
Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage.
Drugs 1993;46 Suppl 1():34-9.
1992: Muhammad Zafarullah; Johanne Martel-Pelletier; Jonathan Cloutier; Lashitew Gedamu; Jean-Pierre Pelletier
Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.
FEBS letters 1992;306(2-3):169-72.
1992: Johanne Martel-Pelletier; R McCollum; JA DiBattista; M P Faure; J A Chin; S Fournier; M Sarfati; Jean-Pierre Pelletier
The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function.
Arthritis and rheumatism 1992;35(5):530-40.
1992: Johanne Martel-Pelletier; Jean-Pierre Pelletier; J M Cloutier; N Rebert; Charles J Malemud
Proteoglycan structural changes in human rheumatoid articular cartilage.
Clinical and experimental rheumatology 1992;10(2):151-9.
1992: Jean-Pierre Pelletier; R McCollum; Jonathan Cloutier; Johanne Martel-Pelletier
Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium.
British journal of rheumatology 1992;31 Suppl 1():19-26.
1991: Johanne Martel-Pelletier; M P Faure; R McCollum; François Mineau; Jonathan Cloutier; Jean-Pierre Pelletier
Plasmin, plasminogen activators and inhibitor in human osteoarthritic cartilage.
The Journal of rheumatology 1991;18(12):1863-71.
1991: Jean-Pierre Pelletier; P J Roughley; JA DiBattista; R McCollum; Johanne Martel-Pelletier
Are cytokines involved in osteoarthritic pathophysiology?
Seminars in arthritis and rheumatism 1991;20(6 Suppl 2):12-25.
1991: Jean-Pierre Pelletier; Johanne Martel-Pelletier
In vivo protective effects of prophylactic treatment with tiaprofenic acid or intraarticular corticosteroids on osteoarthritic lesions in the experimental dog model.
The Journal of rheumatology. Supplement 1991;27():127-30.
1991: B Haraoui; Jean-Pierre Pelletier; Jonathan Cloutier; M P Faure; Johanne Martel-Pelletier
Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs.
Arthritis and rheumatism 1991;34(2):153-63.
1991: Johanne Martel-Pelletier; M Zafarullah; S Kodama; Jean-Pierre Pelletier
In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage.
The Journal of rheumatology. Supplement 1991;27():80-4.
1991: JA DiBattista; Johanne Martel-Pelletier; Jonathan Cloutier; Jean-Pierre Pelletier
Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins.
The Journal of rheumatology. Supplement 1991;27():102-5.
1991: JA DiBattista; Johanne Martel-Pelletier; L O Wosu; T Sandor; T Antakly; Jean-Pierre Pelletier
Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes.
The Journal of clinical endocrinology and metabolism 1991;72(2):316-26.
1991: R McCollum; Johanne Martel-Pelletier; JA DiBattista; Jean-Pierre Pelletier
Regulation of interleukin 1 receptors in human articular chondrocytes.
The Journal of rheumatology. Supplement 1991;27():85-8.
1990: Jean-Pierre Pelletier; François Mineau; M P Faure; Johanne Martel-Pelletier
Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis.
Arthritis and rheumatism 1990;33(10):1466-76.
1989: Jean-Pierre Pelletier; Johanne Martel-Pelletier
Evidence for the involvement of interleukin 1 in human osteoarthritic cartilage degradation: protective effect of NSAID.
The Journal of rheumatology. Supplement 1989;18():19-27.
1989: Jean-Pierre Pelletier; Jonathan Cloutier; Johanne Martel-Pelletier
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage.
The Journal of rheumatology 1989;16(5):646-55.
1989: Jean-Pierre Pelletier; Johanne Martel-Pelletier
The therapeutic effects of NSAID and corticosteroids in osteoarthritis: to be or not to be.
The Journal of rheumatology 1989;16(3):266-9.
1989: Jean-Pierre Pelletier; Johanne Martel-Pelletier
Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis.
Arthritis and rheumatism 1989;32(2):181-93.
1989: Johanne Martel-Pelletier; Jean-Pierre Pelletier
Molecular basis for the action of tiaprofenic acid on human osteoarthritic cartilage degradation.
Seminars in arthritis and rheumatism 1989;18(3 Suppl 1):19-26.
1988: Johanne Martel-Pelletier; Jonathan Cloutier; Jean-Pierre Pelletier
In vivo effects of antirheumatic drugs on neutral collagenolytic proteases in human rheumatoid arthritis cartilage and synovium.
The Journal of rheumatology 1988;15(8):1198-204.
1988: Jean-Pierre Pelletier; Johanne Martel-Pelletier
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on human osteoarthritic cartilage degradation and synovial collagenase synthesis.
Drugs 1988;35 Suppl 1():42-5.