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Jean-Pierre Pelletier

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
203
Martel-Pelletier, Johanne
34
Tardif, Ginette
30
Fernandes, Julio
29
Lajeunesse, Daniel
29
Boileau, Christelle
28
Mineau, François
27
Cloutier, Jonathan
23
Fahmi, Hassan
23
Raynauld, Jean-Pierre
23
Reboul, Pascal
22
DiBattista, JA
20
Di Battista, John
19
Duval, Nicolas
16
Ranger, Pierre
13
Haraoui, Boulos

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Publications

TOP 3
Kwan Tat Steeve; Amiable Nathalie; Pelletier Jean-Pierre; Boileau Christelle; Lajeunesse Daniel; Duval Nicolas; Martel-Pelletier Johanne
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.
Martel-Pelletier Johanne; Pelletier Jean-Pierre
Osteoarthritis: A single injection of anakinra for treating knee OA?
Amiable Nathalie; Tat Steeve Kwan; Lajeunesse Daniel; Duval Nicolas; Pelletier Jean-Pierre; Martel-Pelletier Johanne; Boileau Christelle
Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.

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All Publications

2009: Kwan Tat Steeve; Amiable Nathalie; Pelletier Jean-Pierre; Boileau Christelle; Lajeunesse Daniel; Duval Nicolas; Martel-Pelletier Johanne
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.
Rheumatology (Oxford, England) 2009;48(12):1482-90.
2009: Martel-Pelletier Johanne; Pelletier Jean-Pierre
Osteoarthritis: A single injection of anakinra for treating knee OA?
Nature reviews. Rheumatology 2009;5(7):363-4.
2009: Amiable Nathalie; Tat Steeve Kwan; Lajeunesse Daniel; Duval Nicolas; Pelletier Jean-Pierre; Martel-Pelletier Johanne; Boileau Christelle
Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Bone 2009;44(6):1143-50.
2009: Raynauld J-P; Martel-Pelletier J; Bias P; Laufer S; Haraoui B; Choquette D; Beaulieu A D; Abram F; Dorais M; Vignon E; Pelletier J-P;
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.
Annals of the rheumatic diseases 2009;68(6):938-47.
2009: Fan Z; Tardif G; Hum D; Duval N; Pelletier J-P; Martel-Pelletier J
Hsp90{beta} and p130(cas): novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes.
Annals of the rheumatic diseases 2009;68(6):976-82.
2009: Couchourel Denis; Aubry Isabelle; Delalandre Aline; Lavigne Martin; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Lajeunesse Daniel
Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production.
Arthritis and rheumatism 2009;60(5):1438-50.
2009: Tat Steeve Kwan; Pelletier Jean-Pierre; Velasco Carmen Ruiz; Padrines Marc; Martel-Pelletier Johanne
New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?
The Keio journal of medicine 2009;58(1):29-40.
2009: Pelletier Jean-Pierre; Martel-Pelletier Johanne
Imaging in osteoarthritis trials: useful or just expensive?
Nature clinical practice. Rheumatology 2009;5(2):76-7.
2009: Tardif G; Pelletier J-P; Boileau C; Martel-Pelletier J
The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(2):263-70.
2009: Kwan Tat Steeve; Pelletier Jean-Pierre; Amiable Nathalie; Boileau Christelle; Lavigne Martin; Martel-Pelletier Johanne
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.
Arthritis research & therapy 2009;11(4):R119.
2009: Chabane Nadir; Zayed Nadia; Benderdour Mohamed; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Duval Nicolas; Fahmi Hassan
Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.
Arthritis research & therapy 2009;11(2):R44.
2009: Boileau Christelle; Martel-Pelletier Johanne; Caron Judith; Msika Philippe; Guillou Georges B; Baudouin Caroline; Pelletier Jean-Pierre
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Arthritis research & therapy 2009;11(2):R41.
2008: Kwan Tat Steeve; Pelletier Jean-Pierre; Amiable Nathalie; Boileau Christelle; Lajeunesse Daniel; Duval Nicolas; Martel-Pelletier Johanne
Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
Arthritis and rheumatism 2008;58(12):3820-30.
2008: Zayed Nadia; Afif Hassan; Chabane Nadir; Mfuna-Endam Leandra; Benderdour Mohamed; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Motiani Rajender K; Trebak Mohamed; Duval Nicolas; Fahmi Hassan
Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.
Arthritis and rheumatism 2008;58(11):3530-40.
2008: d'Anjou M-A; Troncy E; Moreau M; Abram F; Raynauld J-P; Martel-Pelletier J; Pelletier J-P
Temporal assessment of bone marrow lesions on magnetic resonance imaging in a canine model of knee osteoarthritis: impact of sequence selection.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(11):1307-11.
2008: Chabane N; Zayed N; Afif H; Mfuna-Endam L; Benderdour M; Boileau C; Martel-Pelletier J; Pelletier J-P; Duval N; Fahmi H
Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(10):1267-74.
2008: Tat Steeve Kwan; Pelletier Jean-Pierre; Lajeunesse Daniel; Fahmi Hassan; Duval Nicolas; Martel-Pelletier Johanne
Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors.
Bone 2008;43(2):284-91.
2008: Boileau C; Martel-Pelletier J; Abram F; Raynauld J-P; Troncy E; D'Anjou M-A; Moreau M; Pelletier J-P
Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis.
Annals of the rheumatic diseases 2008;67(7):926-32.
2008: Raynauld J-P; Martel-Pelletier J; Berthiaume M-J; Abram F; Choquette D; Haraoui B; Beary J F; Cline G A; Meyer J M; Pelletier J-P
Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period.
Annals of the rheumatic diseases 2008;67(5):683-8.
2008: Martel-Pelletier Johanne; Boileau Christelle; Pelletier Jean-Pierre; Roughley Peter J
Cartilage in normal and osteoarthritis conditions.
Best practice & research. Clinical rheumatology 2008;22(2):351-84.
2008: Kwan Tat S; Pelletier J-P; Lajeunesse D; Fahmi H; Lavigne M; Martel-Pelletier J
The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells.
Clinical and experimental rheumatology 2008;26(2):295-304.
2008: D'Anjou Marc-André; Moreau Maxim; Troncy Eric; Martel-Pelletier Johanne; Abram François; Raynauld Jean-Pierre; Pelletier Jean-Pierre
Osteophytosis, subchondral bone sclerosis, joint effusion and soft tissue thickening in canine experimental stifle osteoarthritis: comparison between 1.5 T magnetic resonance imaging and computed radiography.
Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons 2008;37(2):166-77.
2008: Boileau C; Poirier F; Pelletier J-P; Guévremont M; Duval N; Martel-Pelletier J; Reboul P
Intracellular localisation of galectin-3 has a protective role in chondrocyte survival.
Annals of the rheumatic diseases 2008;67(2):175-81.
2008: Zayed Nadia; Li Xinfang; Chabane Nadir; Benderdour Mohamed; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Duval Nicolas; Fahmi Hassan
Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.
Arthritis research & therapy 2008;10(6):R146.
2008: Raynauld Jean-Pierre; Martel-Pelletier Johanne; Abram François; Dorais Marc; Haraoui Boulos; Choquette Denis; Bias Peter; Emmert Karl H; Laufer Stefan; Pelletier Jean-Pierre
Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.
Arthritis research & therapy 2008;10(6):R129.
2008: Pelletier J-P; Raynauld J-P; Abram F; Haraoui B; Choquette D; Martel-Pelletier J
A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16 Suppl 3():S8-13.
2008: Boileau Christelle; Tat Steeve Kwan; Pelletier Jean-Pierre; Cheng Saranette; Martel-Pelletier Johanne
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.
Arthritis research & therapy 2008;10(3):R71.
2007: Haraoui Boulos; Pelletier Jean-Pierre; Martel-Pelletier Johanne
Immunogenicity of biologic agents: a new concern for the practicing rheumatologist?
Current rheumatology reports 2007;9(4):265-7.
2007: Boileau Christelle; Martel-Pelletier Johanne; Fahmi Hassan; Mineau François; Boily Martin; Pelletier Jean-Pierre
The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways.
Arthritis and rheumatism 2007;56(7):2288-98.
2007: Boileau Christelle; Amiable Nathalie; Martel-Pelletier Johanne; Fahmi Hassan; Duval Nicolas; Pelletier Jean-Pierre
Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study.
Arthritis research & therapy 2007;9(6):R121.
2007: Tat Steeve Kwan; Pelletier Jean-Pierre; Vergés Josep; Lajeunesse Daniel; Montell Eulàlia; Fahmi Hassan; Lavigne Martin; Martel-Pelletier Johanne
Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study.
Arthritis research & therapy 2007;9(6):R117.
2007: Pelletier Jean-Pierre; Martel-Pelletier Johanne
DMOAD developments: present and future.
Bulletin of the NYU hospital for joint diseases 2007;65(3):242-8.
2007: Pelletier Jean-Pierre; Raynauld Jean-Pierre; Berthiaume Marie-Josée; Abram François; Choquette Denis; Haraoui Boulos; Beary John F; Cline Gary A; Meyer Joan M; Martel-Pelletier Johanne
Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study.
Arthritis research & therapy 2007;9(4):R74.
2007: Afif Hassan; Benderdour Mohamed; Mfuna-Endam Leandra; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Duval Nicholas; Fahmi Hassan
Peroxisome proliferator-activated receptor gamma1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1beta in articular chondrocytes.
Arthritis research & therapy 2007;9(2):R31.
2007: Janelle-Montcalm Audrée; Boileau Christelle; Poirier Françoise; Pelletier Jean-Pierre; Guévremont Mélanie; Duval Nicolas; Martel-Pelletier Johanne; Reboul Pascal
Extracellular localization of galectin-3 has a deleterious role in joint tissues.
Arthritis research & therapy 2007;9(1):R20.
2006: Bingham Clifton O; Buckland-Wright J Chris; Garnero Patrick; Cohen Stanley B; Dougados Maxime; Adami Silvano; Clauw Daniel J; Spector Timothy D; Pelletier Jean-Pierre; Raynauld Jean-Pierre; Strand Vibeke; Simon Lee S; Meyer Joan M; Cline Gary A; Beary John F
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study.
Arthritis and rheumatism 2006;54(11):3494-507.
2006: Cheng S; Afif H; Martel-Pelletier J; Benderdour M; Pelletier J-P; Hilal G; Haraoui P; Raynauld J-P; Choquette D; Fahmi H
Association of polymorphisms in the peroxisome proliferator-activated receptor gamma gene and osteoarthritis of the knee.
Annals of the rheumatic diseases 2006;65(10):1394-7.
2006: Fan Zhiyong; Tardif Ginette; Boileau Christelle; Bidwell Joseph P; Geng Changshan; Hum David; Watson Alexander; Pelletier Jean-Pierre; Lavigne Martin; Martel-Pelletier Johanne
Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter.
Arthritis and rheumatism 2006;54(8):2471-80.
2006: Moreau Maxim; Boileau Christelle; Martel-Pelletier Johanne; Brunet Julie; Laufer Stefan; Pelletier Jean-Pierre
Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
The Journal of rheumatology 2006;33(6):1176-83.
2006: Boileau C; Martel-Pelletier J; Brunet J; Schrier D; Flory C; Boily M; Pelletier J-P
PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect.
Annals of the rheumatic diseases 2006;65(5):573-80.
2006: Maheu E; Altman R D; Bloch D A; Doherty M; Hochberg M; Mannoni A; Punzi L; Spector T; Verbruggen G; Carr A; Cicuttini F; Dreiser R L; Haraoui B P; Hart D; Pelletier J -P; Ramonda R; Rovati L
Design and conduct of clinical trials in patients with osteoarthritis of the hand: recommendations from a task force of the Osteoarthritis Research Society International.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(4):303-22.
2006: Massicotte Frédéric; Fernandes Julio Cesar; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Lajeunesse Daniel
Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts.
Bone 2006;38(3):333-41.
2006: Martel-Pelletier Johanne; Lajeunesse Daniel; Fahmi Hassan; Tardif Ginette; Pelletier Jean-Pierre
New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.
Current rheumatology reports 2006;8(1):30-6.
2006: Tardif G; Pelletier J-P; Hum D; Boileau C; Duval N; Martel-Pelletier J
Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes.
Annals of the rheumatic diseases 2006;65(2):261-4.
2006: Maxis Kelitha; Delalandre Aline; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Duval Nicolas; Lajeunesse Daniel
The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.
Arthritis research & therapy 2006;8(6):R181.
2006: Massicotte Frédéric; Aubry Isabelle; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Fernandes Julio; Lajeunesse Daniel
Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts.
Arthritis research & therapy 2006;8(6):R177.
2006: Pelletier Jean-Pierre; Martel-Pelletier Johanne; Raynauld Jean-Pierre
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.
Arthritis research & therapy 2006;8(2):206.
2006: Monfort Jordi; Tardif Ginette; Reboul Pascal; Mineau François; Roughley Peter; Pelletier Jean-Pierre; Martel-Pelletier Johanne
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
Arthritis research & therapy 2006;8(1):R26.
2006: Raynauld Jean-Pierre; Martel-Pelletier Johanne; Berthiaume Marie-Josée; Beaudoin Gilles; Choquette Denis; Haraoui Boulos; Tannenbaum Hyman; Meyer Joan M; Beary John F; Cline Gary A; Pelletier Jean-Pierre
Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes.
Arthritis research & therapy 2006;8(1):R21.
2005: Pelletier Jean-Pierre; Martel-Pelletier Johanne
New trends in the treatment of osteoarthritis.
Seminars in arthritis and rheumatism 2005;34(6 Suppl 2):13-4.
2005: Martel-Pelletier Johanne; Pelletier Jean-Pierre
New insights into the major pathophysiological processes responsible for the development of osteoarthritis.
Seminars in arthritis and rheumatism 2005;34(6 Suppl 2):6-8.
2005: Boileau C; Pelletier J-P; Tardif G; Fahmi H; Laufer S; Lavigne M; Martel-Pelletier J
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
Annals of the rheumatic diseases 2005;64(6):891-8.
2005: Li Xinfang; Afif Hassan; Cheng Saranette; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Ranger Pierre; Fahmi Hassan
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.
The Journal of rheumatology 2005;32(5):887-95.
2005: Marcouiller Patrick; Pelletier Jean-Pierre; Guévremont Mélanie; Martel-Pelletier Johanne; Ranger Pierre; Laufer Stefan; Reboul Pascal
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
The Journal of rheumatology 2005;32(4):704-12.
2005: Lavigne P; Benderdour M; Lajeunesse D; Reboul P; Shi Q; Pelletier J-P; Martel-Pelletier J; Fernandes J C
Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2005;13(4):310-7.
2005: Lajeunesse Daniel; Pelletier Jean-Pierre; Martel-Pelletier Johanne
Osteoarthritis: a metabolic disease induced by local abnormal leptin activity?
Current rheumatology reports 2005;7(2):79-81.
2005: Berthiaume M-J; Raynauld J-P; Martel-Pelletier J; Labonté F; Beaudoin G; Bloch D A; Choquette D; Haraoui B; Altman R D; Hochberg M; Meyer J M; Cline G A; Pelletier J-P
Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging.
Annals of the rheumatic diseases 2005;64(4):556-63.
2005: Moreau M; Daminet S; Martel-Pelletier J; Fernandes J; Pelletier J-P
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs.
Journal of veterinary pharmacology and therapeutics 2005;28(1):81-6.
2005: Boileau Christelle; Martel-Pelletier Johanne; Brunet Julie; Tardif Ginette; Schrier Denis; Flory Craig; El-Kattan Ayman; Boily Martin; Pelletier Jean-Pierre
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Arthritis and rheumatism 2005;52(2):488-500.
2005: Farrajota Katherine; Cheng Saranette; Martel-Pelletier Johanne; Afif Hassan; Pelletier Jean-Pierre; Li Xinfang; Ranger Pierre; Fahmi Hassan
Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism.
Arthritis and rheumatism 2005;52(1):94-104.
2005: Pelletier Jean-Pierre; Boileau Christelle; Boily Martin; Brunet Julie; Mineau François; Geng Changshen; Reboul Pascal; Laufer Stefan; Lajeunesse Daniel; Martel-Pelletier Johanne
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Arthritis research & therapy 2005;7(5):R1091-102.
2005: Manacu Christina Alexandra; Martel-Pelletier Johanne; Roy-Beaudry Marjolaine; Pelletier Jean-Pierre; Fernandes Julio C; Shipkolye Fazool S; Mitrovic Dragoslav R; Moldovan Florina
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.
Arthritis research & therapy 2005;7(2):R324-32.
2004: Martel-Pelletier Johanne; Mineau François; Fahmi Hassan; Laufer Stefan; Reboul Pascal; Boileau Christelle; Lavigne Martin; Pelletier Jean-Pierre
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Arthritis and rheumatism 2004;50(12):3925-33.
2004: Tardif Ginette; Hum David; Pelletier Jean-Pierre; Boileau Christelle; Ranger Pierre; Martel-Pelletier Johanne
Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
Arthritis and rheumatism 2004;50(8):2521-30.
2004: Guévremont M; Martel-Pelletier J; Boileau C; Liu F-T; Richard M; Fernandes J-C; Pelletier J-P; Reboul P
Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3.
Annals of the rheumatic diseases 2004;63(6):636-43.
2004: Cheng Saranette; Afif Hassan; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Li Xinfang; Farrajota Katherine; Lavigne Martin; Fahmi Hassan
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
The Journal of biological chemistry 2004;279(21):22057-65.
2004: Pelletier Jean-Pierre; Boileau Christelle; Brunet Julie; Boily Martin; Lajeunesse Daniel; Reboul Pascal; Laufer Stefan; Martel-Pelletier Johanne
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
Bone 2004;34(3):527-38.
2004: Raynauld Jean-Pierre; Martel-Pelletier Johanne; Berthiaume Marie-Josée; Labonté Françoys; Beaudoin Gilles; de Guise Jacques A; Bloch Daniel A; Choquette Denis; Haraoui Boulos; Altman Roy D; Hochberg Marc C; Meyer Joan M; Cline Gary A; Pelletier Jean-Pierre
Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes.
Arthritis and rheumatism 2004;50(2):476-87.
2004: Lajeunesse D; Martel-Pelletier J; Fernandes J C; Laufer S; Pelletier J-P
Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis.
Annals of the rheumatic diseases 2004;63(1):78-83.
2004: Tardif Ginette; Reboul Pascal; Pelletier Jean-Pierre; Martel-Pelletier Johanne
Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3).
Modern rheumatology / the Japan Rheumatism Association 2004;14(3):197-204.
2004: Pelletier Jean-Pierre
Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12 Suppl A():S63-8.
2003: Martel-Pelletier Johanne; Pelletier Jean-Pierre; Fahmi Hassan
Cyclooxygenase-2 and prostaglandins in articular tissues.
Seminars in arthritis and rheumatism 2003;33(3):155-67.
2003: Pelletier J-P; Martel-Pelletier J
Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii79-82.
2003: Roy-Beaudry Marjolaine; Martel-Pelletier Johanne; Pelletier Jean-Pierre; M'Barek Khatija Nait; Christgau Stephan; Shipkolye Fazool; Moldovan Florina
Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction.
Arthritis and rheumatism 2003;48(10):2855-64.
2003: Lajeunesse Daniel; Delalandre Aline; Martel-Pelletier Johanne; Pelletier Jean Pierre
Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts.
Bone 2003;33(4):703-10.
2003: Kauffmann Claude; Gravel Pierre; Godbout Benoît; Gravel Alain; Beaudoin Gilles; Raynauld Jean-Pierre; Martel-Pelletier Johanne; Pelletier Jean-Pierre; de Guise Jacques A
Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model.
IEEE transactions on bio-medical engineering 2003;50(8):978-88.
2003: Tardif G; Dupuis M; Reboul P; Geng C S; Pelletier J-P; Ranger P; Martel-Pelletier J
Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(7):524-37.
2003: Guévremont Melanie; Martel-Pelletier Johanne; Massicotte Frédéric; Tardif Ginette; Pelletier Jean-Pierre; Ranger Pierre; Lajeunesse Daniel; Reboul Pascal
Human adult chondrocytes express hepatocyte growth factor (HGF) isoforms but not HgF: potential implication of osteoblasts on the presence of HGF in cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(6):1073-81.
2003: Pelletier Jean-Pierre; Fernandes Julio C; Brunet Julie; Moldovan Florina; Schrier Denis; Flory Craig; Martel-Pelletier Johanne
In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes.
Arthritis and rheumatism 2003;48(6):1582-93.
2003: Martel-Pelletier J; Lajeunesse D; Reboul P; Pelletier J-P
Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.
Annals of the rheumatic diseases 2003;62(6):501-9.
2003: Raynauld J-P; Kauffmann C; Beaudoin G; Berthiaume M-J; de Guise J A; Bloch D A; Camacho F; Godbout B; Altman R D; Hochberg M; Meyer J M; Cline G; Pelletier J-P; Martel-Pelletier J
Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(5):351-60.
2003: Pelletier J P; Mineau F; Boileau C; Martel-Pelletier J
Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.
Clinical and experimental rheumatology 2003;21(2):171-7.
2003: Raynauld Jean-Pierre; Buckland-Wright Chris; Ward Rupert; Choquette Denis; Haraoui Boulos; Martel-Pelletier Johanne; Uthman Imad; Khy Visithan; Tremblay Jean-Luc; Bertrand Carole; Pelletier Jean-Pierre
Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial.
Arthritis and rheumatism 2003;48(2):370-7.
2002: Pacquelet Sandrine; Presle Nathalie; Boileau Christelle; Dumond Hélène; Netter Patrick; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Terlain Bernard; Jouzeau Jean-Yves
Interleukin 17, a nitric oxide-producing cytokine with a peroxynitrite-independent inhibitory effect on proteoglycan synthesis.
The Journal of rheumatology 2002;29(12):2602-10.
2002: Lavigne P; Shi Q; Jolicoeur F C; Pelletier J-P; Martel-Pelletier J; Fernandes J C
Modulation of IL-1beta, IL-6, TNF-alpha and PGE(2) by pharmacological agents in explants of membranes from failed total hip replacement.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(11):898-904.
2002: Fahmi H; Pelletier J-P; Mineau F; Martel-Pelletier J
15d-PGJ(2) is acting as a 'dual agent' on the regulation of COX-2 expression in human osteoarthritic chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(11):845-8.
2002: Boileau Christelle; Martel-Pelletier Johanne; Moldovan Florina; Jouzeau Jean-Yves; Netter Patrick; Manning Pamela T; Pelletier Jean-Pierre
The in situ up-regulation of chondrocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide.
Arthritis and rheumatism 2002;46(10):2637-47.
2002: Jovanovic Dragan V; Mineau François; Notoya Kohei; Reboul Pascal; Martel-Pelletier Johanne; Pelletier Jean-Pierre
Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.
The Journal of rheumatology 2002;29(10):2165-75.
2002: Boileau Christelle; Martel-Pelletier Johanne; Jouzeau Jean-Yves; Netter Patrick; Moldovan Florina; Laufer Stefan; Tries Susanne; Pelletier Jean-Pierre
Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.
The Journal of rheumatology 2002;29(7):1446-53.
2002: Shi Qin; Lajeunesse Daniel; Reboul Pascal; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Dehnade Faramaze; Fernandes Julio C
Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening.
The Journal of rheumatology 2002;29(7):1437-45.
2002: Paredes Yosabeth; Massicotte Frédéric; Pelletier Jean-Pierre; Martel-Pelletier Johanne; Laufer Stefan; Lajeunesse Daniel
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
Arthritis and rheumatism 2002;46(7):1804-12.
2002: Benderdour Mohamed; Tardif Ginette; Pelletier Jean-Pierre; Di Battista John A; Reboul Pascal; Ranger Pierre; Martel-Pelletier Johanne
Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta.
The Journal of rheumatology 2002;29(6):1262-72.
2002: Massicotte F; Lajeunesse D; Benderdour M; Pelletier J-P; Hilal G; Duval N; Martel-Pelletier J
Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(6):491-500.
2002: He Wendy; Pelletier Jean-Pierre; Martel-Pelletier Johanne; Laufer Stefan; Di Battista John A
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
The Journal of rheumatology 2002;29(3):546-53.
2002: Benderdour Mohamed; Tardif Ginette; Pelletier Jean-Pierre; Dupuis Martine; Geng Changshan; Martel-Pelletier Johanne
A novel negative regulatory element in the human collagenase-3 proximal promoter region.
Biochemical and biophysical research communications 2002;291(5):1151-9.
2002: Fahmi H; Pelletier J-P; Di Battista J A; Cheung H S; Fernandes J C; Martel-Pelletier J
Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(2):100-8.
2002: Kalajdzic Tanja; Faour Wissam H; He Qing Wen; Fahmi Hassan; Martel-Pelletier Johanne; Pelletier Jean-Pierre; Di Battista John A
Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism.
Arthritis and rheumatism 2002;46(2):494-506.
2002: Fernandes Julio C; Martel-Pelletier Johanne; Pelletier Jean-Pierre
The role of cytokines in osteoarthritis pathophysiology.
Biorheology 2002;39(1-2):237-46.
2002: Pelletier Jean-Pierre; Martel-Pelletier Johanne
The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man.
Arthritis research 2002;4(1):13-9.
2001: Martel-Pelletier J; Raynauld J P; Pelletier J P
Quantitative imaging of the structural changes of osteoarthritis: an exciting challenge for the new millennium.
Current rheumatology reports 2001;3(6):465-6.
2001: Pelletier J P; Fernandes J C; Jovanovic D V; Reboul P; Martel-Pelletier J
Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.
The Journal of rheumatology 2001;28(11):2509-19.
2001: Jovanovic D V; Fernandes J C; Martel-Pelletier J; Jolicoeur F C; Reboul P; Laufer S; Tries S; Pelletier J P
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Arthritis and rheumatism 2001;44(10):2320-30.
2001: Tardif G; Reboul P; Dupuis M; Geng C; Duval N; Pelletier J P; Martel-Pelletier J
Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites.
The Journal of rheumatology 2001;28(7):1631-9.
2001: Pelletier J P; Martel-Pelletier J; Abramson S B
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.
Arthritis and rheumatism 2001;44(6):1237-47.
2001: Fahmi H; He Y; Zhang M; Martel-Pelletier J; Pelletier J P; Di Battista J A
Nimesulide reduces interleukin-1beta-induced cyclooxygenase-2 gene expression in human synovial fibroblasts.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(4):332-40.
2001: Pelletier J P; Lajeunesse D; Reboul P; Mineau F; Fernandes J C; Sabouret P; Martel-Pelletier J
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.
The Journal of rheumatology 2001;28(4):814-24.
2001: Jovanovic D V; Di Battista J A; Martel-Pelletier J; Reboul P; He Y; Jolicoeur F C; Pelletier J P
Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages.
The Journal of rheumatology 2001;28(4):712-8.
2001: Hilal G; Massicotte F; Martel-Pelletier J; Fernandes J C; Pelletier J P; Lajeunesse D
Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):713-21.
2001: Fahmi H; Di Battista J A; Pelletier J P; Mineau F; Ranger P; Martel-Pelletier J
Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes.
Arthritis and rheumatism 2001;44(3):595-607.
2001: Reboul P; Pelletier J P; Tardif G; Benderdour M; Ranger P; Bottaro D P; Martel-Pelletier J
Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade.
Arthritis and rheumatism 2001;44(1):73-84.
2001: Di Battista J A; Fahmi H; He Y; Zhang M; Martel-Pelletier J; Pelletier J P
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Clinical and experimental rheumatology 2001;19(1 Suppl 22):S3-5.
2000: Pelletier J P; Lajeunesse D; Jovanovic D V; Lascau-Coman V; Jolicoeur F C; Hilal G; Fernandes J C; Martel-Pelletier J
Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis.
The Journal of rheumatology 2000;27(12):2893-902.
2000: Pelletier J P; Yaron M; Haraoui B; Cohen P; Nahir M A; Choquette D; Wigler I; Rosner I A; Beaulieu A D
Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group.
Arthritis and rheumatism 2000;43(10):2339-48.
2000: Moldovan F; Pelletier J P; Mineau F; Dupuis M; Cloutier J M; Martel-Pelletier J
Modulation of collagenase 3 in human osteoarthritic cartilage by activation of extracellular transforming growth factor beta: role of furin convertase.
Arthritis and rheumatism 2000;43(9):2100-9.
2000: Notoya K; Jovanovic D V; Reboul P; Martel-Pelletier J; Mineau F; Pelletier J P
The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3402-10.
2000: Pelletier J P; Jovanovic D V; Lascau-Coman V; Fernandes J C; Manning P T; Connor J R; Currie M G; Martel-Pelletier J
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level.
Arthritis and rheumatism 2000;43(6):1290-9.
2000: Jovanovic D V; Martel-Pelletier J; Di Battista J A; Mineau F; Jolicoeur F C; Benderdour M; Pelletier J P
Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(5):1134-44.
2000: Moldovan F; Pelletier J P; Jolicoeur F C; Cloutier J M; Martel-Pelletier J
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8(3):186-96.
1999: Alaaeddine N; Di Battista J A; Pelletier J P; Kiansa K; Cloutier J M; Martel-Pelletier J
Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts.
Cytokine 1999;11(12):1020-30.
1999: Zhang M; Miller C; He Y; Martel-Pelletier J; Pelletier J P; Di Battista J A
Calphostin C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein kinase C-alpha inhibition: possible role for c-jun N-terminal kinase.
Journal of cellular biochemistry 1999;76(2):290-302.
1999: Martel-Pelletier J; Mineau F; Jovanovic D; Di Battista J A; Pelletier J P
Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated proten kinase (MAPKAPK).
Arthritis and rheumatism 1999;42(11):2399-409.
1999: Pelletier J P; Choquette D; Haraoui B; Raynauld J P; Rich E; Fernandes J C; Martel-Pelletier J
Pharmacologic therapy of osteoarthritis.
Current rheumatology reports 1999;1(1):54-8.
1999: Martel-Pelletier J; Alaaeddine N; Pelletier J P
Cytokines and their role in the pathophysiology of osteoarthritis.
Frontiers in bioscience : a journal and virtual library 1999;4():D694-703.
1999: Hilal G; Martel-Pelletier J; Pelletier J P; Duval N; Lajeunesse D
Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts.
Arthritis and rheumatism 1999;42(10):2112-22.
1999: Pelletier J P; Lascau-Coman V; Jovanovic D; Fernandes J C; Manning P; Connor J R; Currie M G; Martel-Pelletier J
Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
The Journal of rheumatology 1999;26(9):2002-14.
1999: Saha N; Moldovan F; Tardif G; Pelletier J P; Cloutier J M; Martel-Pelletier J
Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1beta and interleukin-18.
Arthritis and rheumatism 1999;42(8):1577-87.
1999: Pelletier J P
The influence of tissue cross-talking on OA progression: role of nonsteroidal antiinflammatory drugs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(4):374-6.
1999: Tardif G; Pelletier J P; Dupuis M; Geng C; Cloutier J M; Martel-Pelletier J
Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells.
Arthritis and rheumatism 1999;42(6):1147-58.
1999: Pelletier J P; Di Battista J A; Zhang M; Fernandes J; Alaaeddine N; Martel-Pelletier J
Effect of nimesulide on glucocorticoid receptor activity in human synovial fibroblasts.
Rheumatology (Oxford, England) 1999;38 Suppl 1():11-3.
1999: Pelletier J P
Pathophysiological targets in OA therapy.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):353-4.
1999: Pelletier J P; Lajeunesse D; Hilal G; Jovanovic D; Fernandes J C; Martel-Pelletier J
Carprofen reduces the structural changes and the abnormal subchondral bone metabolism of experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):327-8.
1999: Lajeunesse D; Hilal G; Pelletier J P; Martel-Pelletier J
Subchondral bone morphological and biochemical alterations in osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):321-2.
1999: Pelletier J P; Reginster J Y
The influence of tissular cross-talking on osteoarthritis progression: role of nonsteroidal antiinflammatory drugs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):306-7.
1999: Fernandes J; Tardif G; Martel-Pelletier J; Lascau-Coman V; Dupuis M; Moldovan F; Sheppard M; Krishnan B R; Pelletier J P
In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression.
The American journal of pathology 1999;154(4):1159-69.
1999: Alaaeddine N; Di Battista J A; Pelletier J P; Kiansa K; Cloutier J M; Martel-Pelletier J
Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways.
Arthritis and rheumatism 1999;42(4):710-8.
1999: Di Battista J A; Zhang M; Martel-Pelletier J; Fernandes J; Alaaeddine N; Pelletier J P
Enhancement of phosphorylation and transcriptional activity of the glucocorticoid receptor in human synovial fibroblasts by nimesulide, a preferential cyclooxygenase 2 inhibitor.
Arthritis and rheumatism 1999;42(1):157-66.
1999: Su S; Grover J; Roughley P J; DiBattista J A; Martel-Pelletier J; Pelletier J P; Zafarullah M
Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints.
Rheumatology international 1999;18(5-6):183-91.
1998: Pelletier J P; Mineau F; Fernandes J C; Duval N; Martel-Pelletier J
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
The Journal of rheumatology 1998;25(12):2417-24.
1998: Fernandes J C; Martel-Pelletier J; Lascau-Coman V; Moldovan F; Jovanovic D; Raynauld J P; Pelletier J P
Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: an immunohistochemical study.
The Journal of rheumatology 1998;25(8):1585-94.
1998: Pelletier J P; Jovanovic D; Fernandes J C; Manning P; Connor J R; Currie M G; Di Battista J A; Martel-Pelletier J
Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.
Arthritis and rheumatism 1998;41(7):1275-86.
1998: Miller C; Zhang M; He Y; Zhao J; Pelletier J P; Martel-Pelletier J; Di Battista J A
Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins.
Journal of cellular biochemistry 1998;69(4):392-413.
1998: Fernandes J C; Martel-Pelletier J; Jovanovic D; Tardif G; DiBattista J A; Lascau-Coman V; Otterness I G; Pelletier J P
The effects of tenidap on canine experimental osteoarthritis: II. Study of the expression of collagenase-1 and interleukin 1beta by in situ hybridization.
The Journal of rheumatology 1998;25(5):951-8.
1998: Hilal G; Martel-Pelletier J; Pelletier J P; Ranger P; Lajeunesse D
Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis.
Arthritis and rheumatism 1998;41(5):891-9.
1998: Martel-Pelletier J; Mineau F; Jolicoeur F C; Cloutier J M; Pelletier J P
In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.
The Journal of rheumatology 1998;25(4):753-62.
1998: Jovanovic D V; Di Battista J A; Martel-Pelletier J; Jolicoeur F C; He Y; Zhang M; Mineau F; Pelletier J P
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3513-21.
1998: Jovanovic D; Pelletier J P; Alaaeddine N; Mineau F; Geng C; Ranger P; Martel-Pelletier J
Effect of IL-13 on cytokines, cytokine receptors and inhibitors on human osteoarthritis synovium and synovial fibroblasts.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(1):40-9.
1998: Fernandes J C; Jovanovic D; Dehnade F; Martel-Pelletier J; Pelletier J P
[Resection of the anterior cruciate ligament of the knee using arthroscopy induces arthrosis in dogs. Validity of the Pond-Nuki model]
Annales de chirurgie 1998;52(8):768-75.
1997: Alaaeddine N; DiBattista J A; Pelletier J P; Cloutier J M; Kiansa K; Dupuis M; Martel-Pelletier J
Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha.
The Journal of rheumatology 1997;24(10):1985-94.
1997: Moldovan F; Pelletier J P; Hambor J; Cloutier J M; Martel-Pelletier J
Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta.
Arthritis and rheumatism 1997;40(9):1653-61.
1997: Pelletier J P; Mineau F; Fernandes J; Kiansa K; Ranger P; Martel-Pelletier J
Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.
Clinical and experimental rheumatology 1997;15(4):393-8.
1997: Pelletier J P; Caron J P; Evans C; Robbins P D; Georgescu H I; Jovanovic D; Fernandes J C; Martel-Pelletier J
In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy.
Arthritis and rheumatism 1997;40(6):1012-9.
1997: Di Battista J A; Doré S; Morin N; He Y; Pelletier J P; Martel-Pelletier J
Prostaglandin E2 stimulates insulin-like growth factor binding protein-4 expression and synthesis in cultured human articular chondrocytes: possible mediation by Ca(++)-calmodulin regulated processes.
Journal of cellular biochemistry 1997;65(3):408-19.
1997: Jovanovic D; Caron J P; Martel-Pelletier J; Fernandes J C; Ricketts T; Pelletier J P
The therapeutic effects of tenidap in canine experimental osteoarthritis: relationship with biochemical markers.
The Journal of rheumatology 1997;24(5):916-25.
1997: Tardif G; Pelletier J P; Dupuis M; Hambor J E; Martel-Pelletier J
Cloning, sequencing and characterization of the 5'-flanking region of the human collagenase-3 gene.
The Biochemical journal 1997;323 ( Pt 1)():13-6.
1997: Fernandes J C; Caron J P; Martel-Pelletier J; Jovanovic D; Mineau F; Tardif G; Otterness I G; Pelletier J P
Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity.
Arthritis and rheumatism 1997;40(2):284-94.
1996: Tavera C; Abribat T; Reboul P; Doré S; Brazeau P; Pelletier J P; Martel-Pelletier J
IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1996;4(4):263-74.
1996: Caron J P; Tardif G; Martel-Pelletier J; DiBattista J A; Geng C; Pelletier J P
Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids.
American journal of veterinary research 1996;57(11):1631-4.
1996: Di Battista J A; Doré S; Martel-Pelletier J; Pelletier J P
Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I.
Molecular and cellular endocrinology 1996;123(1):27-35.
1996: Caron J P; Fernandes J C; Martel-Pelletier J; Tardif G; Mineau F; Geng C; Pelletier J P
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression.
Arthritis and rheumatism 1996;39(9):1535-44.
1996: Tardif G; Reboul P; Pelletier J P; Geng C; Cloutier J M; Martel-Pelletier J
Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins.
Arthritis and rheumatism 1996;39(6):968-78.
1996: Reboul P; Pelletier J P; Tardif G; Cloutier J M; Martel-Pelletier J
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.
The Journal of clinical investigation 1996;97(9):2011-9.
1996: Pelletier J P; Mineau F; Ranger P; Tardif G; Martel-Pelletier J
The increased synthesis of inducible nitric oxide inhibits IL-1ra synthesis by human articular chondrocytes: possible role in osteoarthritic cartilage degradation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1996;4(1):77-84.
1996: Zafarullah M; Su S; Martel-Pelletier J; DiBattista J A; Costello B G; Stetler-Stevenson W G; Pelletier J P
Tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA is constitutively expressed in bovine, human normal, and osteoarthritic articular chondrocytes.
Journal of cellular biochemistry 1996;60(2):211-7.
1996: Martel-Pelletier J; Mineau F; Tardif G; Fernandes J C; Ranger P; Loose L; Pelletier J P
Tenidap reduces the level of interleukin 1 receptors and collagenase expression in human arthritic synovial fibroblasts.
The Journal of rheumatology 1996;23(1):24-31.
1996: Ounissi-Benkalha H; Pelletier J P; Tardif G; Mineau F; Jolicoeur F C; Ranger P; Martel-Pelletier J
In vitro effects of 2 antirheumatic drugs on the synthesis and expression of proinflammatory cytokines in synovial membranes from patients with rheumatoid arthritis.
The Journal of rheumatology 1996;23(1):16-23.
1995: Fernandes J C; Martel-Pelletier J; Otterness I G; Lopez-Anaya A; Mineau F; Tardif G; Pelletier J P
Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis.
Arthritis and rheumatism 1995;38(9):1290-303.
1995: Sadouk M B; Pelletier J P; Tardif G; Kiansa K; Cloutier J M; Martel-Pelletier J
Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor.
Laboratory investigation; a journal of technical methods and pathology 1995;73(3):347-55.
1995: Pelletier J P; DiBattista J A; Raynauld J P; Wilhelm S; Martel-Pelletier J
The in vivo effects of intraarticular corticosteroid injections on cartilage lesions, stromelysin, interleukin-1, and oncogene protein synthesis in experimental osteoarthritis.
Laboratory investigation; a journal of technical methods and pathology 1995;72(5):578-86.
1995: DiBattista J A; Pelletier J P; Zafarullah M; Iwata K; Martel-Pelletier J
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
Journal of cellular biochemistry 1995;57(4):619-29.
1995: Doré S; Abribat T; Rousseau N; Brazeau P; Tardif G; DiBattista J A; Cloutier J M; Pelletier J P; Martel-Pelletier J
Increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes is not dependent on growth hormone action.
Arthritis and rheumatism 1995;38(3):413-9.
1995: DiBattista J A; Pelletier J P; Zafarullah M; Fujimoto N; Obata K; Martel-Pelletier J
Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts.
The Journal of rheumatology. Supplement 1995;43():123-8.
1995: Martel-Pelletier J; Mineau F; Jolicoeur F C; Pelletier J P
Modulation of TNFSR55 and TNFSR75 by cytokines and growth factors in human synovial fibroblasts.
The Journal of rheumatology. Supplement 1995;43():115-9.
1995: Pelletier J P; McCollum R; Cloutier J M; Martel-Pelletier J
Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process.
The Journal of rheumatology. Supplement 1995;43():109-14.
1994: Pelletier J P; Martel-Pelletier J
[Role of synovial inflammation, cytokines and IGF-1 in the physiopathology of osteoarthritis]
Revue du rhumatisme (Ed. française : 1993) 1994;61(9 Pt 2):103S-108S.
1994: Pelletier J P; DiBattista J A; Ranger P; Martel-Pelletier J
The reduced expression of glucocorticoid receptors in synovial cells induced by nonsteroidal antiinflammatory drugs can be reversed by prostaglandin E1 analog.
The Journal of rheumatology 1994;21(9):1748-52.
1994: DiBattista J A; Martel-Pelletier J; Fujimoto N; Obata K; Zafarullah M; Pelletier J P
Prostaglandins E2 and E1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Mediation by cyclic-AMP signalling pathway.
Laboratory investigation; a journal of technical methods and pathology 1994;71(2):270-8.
1994: DiBattista J A; Martel-Pelletier J; Morin N; Jolicoeur F C; Pelletier J P
Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1.
Molecular and cellular endocrinology 1994;103(1-2):139-48.
1994: Martel-Pelletier J; McCollum R; Fujimoto N; Obata K; Cloutier J M; Pelletier J P
Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis.
Laboratory investigation; a journal of technical methods and pathology 1994;70(6):807-15.
1994: Haraoui B; Thonar E J; Martel-Pelletier J; Goulet J R; Raynauld J P; Ouellet M; Pelletier J P
Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographic staging.
The Journal of rheumatology 1994;21(5):813-7.
1994: Pelletier J P; Mineau F; Raynauld J P; Woessner J F; Gunja-Smith Z; Martel-Pelletier J
Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis.
Arthritis and rheumatism 1994;37(3):414-23.
1994: Doré S; Pelletier J P; DiBattista J A; Tardif G; Brazeau P; Martel-Pelletier J
Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins.
Arthritis and rheumatism 1994;37(2):253-63.
1993: Pelletier J P; McCollum R; DiBattista J; Loose L D; Cloutier J M; Martel-Pelletier J
Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs.
Arthritis and rheumatism 1993;36(11):1517-27.
1993: Pelletier J P; DiBattista J A; Roughley P; McCollum R; Martel-Pelletier J
Cytokines and inflammation in cartilage degradation.
Rheumatic diseases clinics of North America 1993;19(3):545-68.
1993: Zafarullah M; Martel-Pelletier J; Cloutier J M; Gedamu L; Pelletier J P
Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1993;1(3):151-6.
1993: DiBattista J A; Martel-Pelletier J; Antakly T; Tardif G; Cloutier J M; Pelletier J P
Reduced expression of glucocorticoid receptor levels in human osteoarthritic chondrocytes. Role in the suppression of metalloprotease synthesis.
The Journal of clinical endocrinology and metabolism 1993;76(5):1128-34.
1993: Zafarullah M; Pelletier J P; Cloutier J M; Martel-Pelletier J
Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia.
The Journal of rheumatology 1993;20(4):693-7.
1993: Martel-Pelletier J; McCollum R; Pelletier J P
The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1.
Biochimica et biophysica acta 1993;1175(3):302-5.
1993: Pelletier J P; Faure M P; DiBattista J A; Wilhelm S; Visco D; Martel-Pelletier J
Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study.
The American journal of pathology 1993;142(1):95-105.
1993: Pelletier J P; Cloutier J M; Martel-Pelletier J
In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes.
Agents and actions. Supplements 1993;39():181-93.
1993: Pelletier J P; Martel-Pelletier J
Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage.
Drugs 1993;46 Suppl 1():34-9.
1992: Zafarullah M; Martel-Pelletier J; Cloutier J M; Gedamu L; Pelletier J P
Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.
FEBS letters 1992;306(2-3):169-72.
1992: Martel-Pelletier J; McCollum R; DiBattista J; Faure M P; Chin J A; Fournier S; Sarfati M; Pelletier J P
The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function.
Arthritis and rheumatism 1992;35(5):530-40.
1992: Martel-Pelletier J; Pelletier J P; Cloutier J M; Rebert N; Malemud C J
Proteoglycan structural changes in human rheumatoid articular cartilage.
Clinical and experimental rheumatology 1992;10(2):151-9.
1992: Pelletier J P; McCollum R; Cloutier J M; Martel-Pelletier J
Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium.
British journal of rheumatology 1992;31 Suppl 1():19-26.
1991: Martel-Pelletier J; Faure M P; McCollum R; Mineau F; Cloutier J M; Pelletier J P
Plasmin, plasminogen activators and inhibitor in human osteoarthritic cartilage.
The Journal of rheumatology 1991;18(12):1863-71.
1991: Pelletier J P; Roughley P J; DiBattista J A; McCollum R; Martel-Pelletier J
Are cytokines involved in osteoarthritic pathophysiology?
Seminars in arthritis and rheumatism 1991;20(6 Suppl 2):12-25.
1991: Pelletier J P; Martel-Pelletier J
In vivo protective effects of prophylactic treatment with tiaprofenic acid or intraarticular corticosteroids on osteoarthritic lesions in the experimental dog model.
The Journal of rheumatology. Supplement 1991;27():127-30.
1991: Haraoui B; Pelletier J P; Cloutier J M; Faure M P; Martel-Pelletier J
Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. In vivo effects of antirheumatic drugs.
Arthritis and rheumatism 1991;34(2):153-63.
1991: Martel-Pelletier J; Zafarullah M; Kodama S; Pelletier J P
In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage.
The Journal of rheumatology. Supplement 1991;27():80-4.
1991: DiBattista J A; Martel-Pelletier J; Cloutier J M; Pelletier J P
Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins.
The Journal of rheumatology. Supplement 1991;27():102-5.
1991: DiBattista J A; Martel-Pelletier J; Wosu L O; Sandor T; Antakly T; Pelletier J P
Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes.
The Journal of clinical endocrinology and metabolism 1991;72(2):316-26.
1991: McCollum R; Martel-Pelletier J; DiBattista J; Pelletier J P
Regulation of interleukin 1 receptors in human articular chondrocytes.
The Journal of rheumatology. Supplement 1991;27():85-8.
1990: Pelletier J P; Mineau F; Faure M P; Martel-Pelletier J
Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritis.
Arthritis and rheumatism 1990;33(10):1466-76.
1989: Pelletier J P; Martel-Pelletier J
Evidence for the involvement of interleukin 1 in human osteoarthritic cartilage degradation: protective effect of NSAID.
The Journal of rheumatology. Supplement 1989;18():19-27.
1989: Pelletier J P; Cloutier J M; Martel-Pelletier J
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage.
The Journal of rheumatology 1989;16(5):646-55.
1989: Pelletier J P; Martel-Pelletier J
The therapeutic effects of NSAID and corticosteroids in osteoarthritis: to be or not to be.
The Journal of rheumatology 1989;16(3):266-9.
1989: Pelletier J P; Martel-Pelletier J
Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis.
Arthritis and rheumatism 1989;32(2):181-93.
1989: Martel-Pelletier J; Pelletier J P
Molecular basis for the action of tiaprofenic acid on human osteoarthritic cartilage degradation.
Seminars in arthritis and rheumatism 1989;18(3 Suppl 1):19-26.
1988: Martel-Pelletier J; Cloutier J M; Pelletier J P
In vivo effects of antirheumatic drugs on neutral collagenolytic proteases in human rheumatoid arthritis cartilage and synovium.
The Journal of rheumatology 1988;15(8):1198-204.
1988: Pelletier J P; Martel-Pelletier J
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on human osteoarthritic cartilage degradation and synovial collagenase synthesis.
Drugs 1988;35 Suppl 1():42-5.

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