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Päivi Peltomäki

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Markku T Aarnio; Annette Gylling; Heikki J Järvinen; Matti Juhola; Päivi Peltomäki; Matti Säily; Jukka-Pekka Mecklin
Uroepithelial and kidney carcinoma in Lynch syndrome.
Wael M Abdel-Rahman; Sakari Knuutila; Salla Ruosaari; Päivi Peltomäki
Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.
Walter Pavicic; Emmi I Joensuu; Taina Nieminen; Päivi Peltomäki
LINE-1 hypomethylation in familial and sporadic cancer.

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2012: Markku T Aarnio; Annette Gylling; Heikki J Järvinen; Matti Juhola; Päivi Peltomäki; Matti Säily; Jukka-Pekka Mecklin
Uroepithelial and kidney carcinoma in Lynch syndrome.
Familial cancer 2012;11(3):395-401.
2012: Wael M Abdel-Rahman; Sakari Knuutila; Salla Ruosaari; Päivi Peltomäki
Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.
World journal of gastroenterology : WJG 2012;18(29):3896-903.
2012: Walter Pavicic; Emmi I Joensuu; Taina Nieminen; Päivi Peltomäki
LINE-1 hypomethylation in familial and sporadic cancer.
Journal of molecular medicine (Berlin, Germany) 2012;90(7):827-35.
2012: E Carlsson; Sampsa Hautaniemi; V Häyry; M Helle; Leena Karenko; S Knuutila; K Niiranen; K Ovaska; Päivi Peltomäki; Annamari Ranki; L Siggberg; LM Sipilä; R Ässämäki; U Aapola; Wael M Abdel-Rahman; Kai Krohn
Potential role of a navigator gene NAV3 in colorectal cancer.
British journal of cancer 2012;106(3):517-24.
2012: Johanna E Lotsari; Jukka-Pekka Mecklin; Taina T Nieminen; Markku T Aarnio; Wael M Abdel-Rahman; Kristiina Aittomäki; Marjukka Friman; Annette Gylling; Heikki J Järvinen; Teijo Kuopio; Reino Pitkänen; Päivi Peltomäki
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases.
Breast cancer research : BCR 2012;14(3):R90.
2011: Päivi Peltomäki; Ralf Bützow
Pathogenesis of endometriosis and its relationship to gynecological cancers.
Epigenomics 2011;3(6):689-90.
2011: Taina T Nieminen; Ari Ristimäki; Wael M Abdel-Rahman; Heikki J Järvinen; Päivi Lahermo; Maarit Lappalainen; Jukka-Pekka Mecklin; Päivi Peltomäki
BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.
Gastroenterology 2011;141(1):e23-6.
2009: Heikki J Järvinen; Laura Renkonen-Sinisalo; Katja Aktán-Collán; Päivi Peltomäki; Lauri A Aaltonen; Jukka-Pekka Mecklin
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(28):4793-7.
2009: Taina T Nieminen; Annette Gylling; Wael M Abdel-Rahman; Kyösti Nuorva; Markku T Aarnio; Laura Renkonen-Sinisalo; Heikki J Järvinen; Jukka-Pekka Mecklin; Ralf Bützow; Päivi Peltomäki
Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5772-83.
2009: Annette Gylling; Maaret Ridanpää; Outi Vierimaa; Kristiina Aittomäki; Kristiina Avela; Helena Kääriäinen; Hannele Laivuori; Minna Pöyhönen; Satu-Leena Sallinen; Carina Wallgren-Pettersson; Heikki J Järvinen; Jukka-Pekka Mecklin; Päivi Peltomäki
Large genomic rearrangements and germline epimutations in Lynch syndrome.
International journal of cancer. Journal international du cancer 2009;124(10):2333-40.
2008: Sonja Hahtola; Elke Burghart; Leila Jeskanen; Leena Karenko; Wael M Abdel-Rahman; Bernhard Polzer; Mikael Kajanti; Päivi Peltomäki; Tom Pettersson; Christoph A Klein; Annamari Ranki
Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma.
The Journal of investigative dermatology 2008;128(9):2304-9.
2008: A H S Gylling; T T Nieminen; Wael M Abdel-Rahman; Kyösti Nuorva; Matti Juhola; E I Joensuu; Heikki J Järvinen; Jukka-Pekka Mecklin; Markku T Aarnio; Päivi Peltomäki
Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors.
Carcinogenesis 2008;29(7):1351-9.
2008: Emmi I Joensuu; Wael M Abdel-Rahman; Miina Ollikainen; Salla Ruosaari; Sakari Knuutila; Päivi Peltomäki
Epigenetic signatures of familial cancer are characteristic of tumor type and family category.
Cancer research 2008;68(12):4597-605.
2008: Wael M Abdel-Rahman; Juliya Kalinina; Soheir Shoman; Saad Eissa; Miina Ollikainen; Outi Elomaa; Anna V Eliseenkova; Ralf Bützow; Moosa Mohammadi; Päivi Peltomäki
Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin.
Human mutation 2008;29(3):390-7.
2008: Wael M Abdel-Rahman; Sakari Knuutila; Päivi Peltomäki; David J Harrison; Scott A Bader
Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells.
DNA repair 2008;7(2):321-8.
2008: Sonja Hahtola; Elke Burghart; Marjut Puputti; Leena Karenko; Wael M Abdel-Rahman; Liisa Väkevä; Leila Jeskanen; Susanna Virolainen; Jaakko Karvonen; Kaisa Salmenkivi; Vuokko Kinnula; Heikki Joensuu; Päivi Peltomäki; Christoph A Klein; Annamari Ranki
Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer.
Genes, chromosomes & cancer 2008;47(2):107-17.
2007: Katja Aktan-Collan; Ari Haukkala; Kirsi Pylvänäinen; Heikki J Järvinen; Lauri A Aaltonen; Päivi Peltomäki; E Rantanen; Helena Kääriäinen; Jukka-Pekka Mecklin
Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing.
Journal of medical genetics 2007;44(11):732-8.
2007: Jukka-Pekka Mecklin; Markku T Aarnio; Esa Läärä; Matti Kairaluoma; Kirsi Pylvänäinen; Päivi Peltomäki; Lauri A Aaltonen; Heikki J Järvinen
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.
Gastroenterology 2007;133(4):1093-8.
2007: Miina Ollikainen; Annette Gylling; Marjut Puputti; Nina N Nupponen; Wael M Abdel-Rahman; Ralf Butzow; Päivi Peltomäki
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma.
International journal of cancer. Journal international du cancer 2007;121(4):915-20.
2007: Miina Ollikainen; Ulf Hannelius; Cecilia M Lindgren; Wael M Abdel-Rahman; Juha Kere; Päivi Peltomäki
Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach.
Oncogene 2007;26(31):4541-9.
2007: A Gylling; Wael M Abdel-Rahman; Matti Juhola; Kyösti Nuorva; E Hautala; Heikki J Järvinen; Jukka-Pekka Mecklin; Markku T Aarnio; Päivi Peltomäki
Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study.
Gut 2007;56(7):926-33.
2007: Kristina Lagerstedt Robinson; Tao Liu; Jana Vandrovcova; Britta Halvarsson; Mark Clendenning; Thierry Frebourg; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Päivi Peltomäki; Richard D Kolodner; Mef Nilbert; Annika Lindblom
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.
Journal of the National Cancer Institute 2007;99(4):291-9.
2006: Saara Ollila; Laura Sarantaus; Reetta Kariola; Philip Chan; Heather Hampel; Elke Holinski-Feder; Finlay Macrae; M R J Kohonen-Corish; Anne-Marie Gerdes; Päivi Peltomäki; Elisabeth Mangold; Albert de La Chapelle; Marc S Greenblatt; Minna Nyström
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.
Gastroenterology 2006;131(5):1408-17.
2006: Wael M Abdel-Rahman; Jukka-Pekka Mecklin; Päivi Peltomäki
The genetics of HNPCC: application to diagnosis and screening.
Critical reviews in oncology/hematology 2006;58(3):208-20.
2006: Johanna Skoglund; Tatjana Djureinovic; X-L Zhou; Jana Vandrovcova; Elise Renkonen; L Iselius; Marie-Luise Bisgaard; Päivi Peltomäki; Annika Lindblom
Linkage analysis in a large Swedish family supports the presence of a susceptibility locus for adenoma and colorectal cancer on chromosome 9q22.32-31.1.
Journal of medical genetics 2006;43(2):e7.
2006: Saara Ollila; Roslyn Fitzpatrick; Laura Sarantaus; Reetta Kariola; Ingrid Ambus; Lea Velsher; Eugene Hsieh; Mette K Andersen; Tiina E Raevaara; Anne-Marie Gerdes; Elisabeth Mangold; Päivi Peltomäki; Henry T Lynch; Minna Nyström
The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC.
International journal of oncology 2006;28(1):149-53.
2005: Kaisa Sotamaa; Sandya Liyanarachchi; Jukka-Pekka Mecklin; Heikki Järvinen; Lauri A Aaltonen; Päivi Peltomäki; Albert de La Chapelle
p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6840-4.
2005: Elise Renkonen; Pekka Nieminen; Wael M Abdel-Rahman; Anu-Liisa Moisio; Irma Järvelä; Sirpa Arte; Heikki J Järvinen; Päivi Peltomäki
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(24):5651-9.
2005: Tiina E Raevaara; Mari K Korhonen; Hannes Lohi; Heather Hampel; Elly Lynch; Karin E Lönnqvist; Elke Holinski-Feder; Christian Sutter; Wendy McKinnon; Sekhar Duraisamy; Anne-Marie Gerdes; Päivi Peltomäki; Maija Kohonen-Ccorish; Elisabeth Mangold; Finlay Macrae; Marc S Greenblatt; Albert de La Chapelle; Minna Nyström
Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1.
Gastroenterology 2005;129(2):537-49.
2005: Miina Ollikainen; Wael M Abdel-Rahman; Anu-Liisa Moisio; Annette Lindroos; Reetta Kariola; Irma Järvelä; Minna Pöyhönen; Ralf Butzow; Päivi Peltomäki
Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(21):4609-16.
2005: Wael M Abdel-Rahman; Miina Ollikainen; Reetta Kariola; Heikki J Järvinen; Jukka-Pekka Mecklin; Minna Nyström-Lahti; Sakari Knuutila; Päivi Peltomäki
Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations.
Oncogene 2005;24(9):1542-51.
2005: Wael M Abdel-Rahman; Hannes Lohi; Sakari Knuutila; Päivi Peltomäki
Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number.
Oncogene 2005;24(4):706-13.
2005: Päivi Peltomäki
Lynch syndrome genes.
Familial cancer 2005;4(3):227-32.
2005: Reetta Kariola; Wael M Abdel-Rahman; Miina Ollikainen; Ralf Butzow; Päivi Peltomäki; Minna Nyström
APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.
Familial cancer 2005;4(2):187-90.
2004: Enric Domingo; Päivi Laiho; Miina Ollikainen; Mafalda Pinto; L Wang; A J French; Jantine L Westra; T Frebourg; Eloi Espín; Manel Armengol; Richard Hamelin; Hiroyuki Yamamoto; Robert M W Hofstra; Raquel Seruca; Annika Lindblom; Päivi Peltomäki; S N Thibodeau; Lauri A Aaltonen; Simó Schwartz
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Journal of medical genetics 2004;41(9):664-8.
2004: Elise Renkonen; Hannes Lohi; Heikki J Järvinen; Jukka-Pekka Mecklin; Päivi Peltomäki
Novel splicing associations of hereditary colon cancer related DNA mismatch repair gene mutations.
Journal of medical genetics 2004;41(7):e95.
2004: Tiina E Raevaara; Anne-Marie Gerdes; Karin E Lönnqvist; Anne Tybjaerg-Hansen; Wael M Abdel-Rahman; Reetta Kariola; Päivi Peltomäki; Minna Nyström-Lahti
HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1.
Genes, chromosomes & cancer 2004;40(3):261-5.
2004: Päivi Peltomäki; H F A Vasen
Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database.
Disease markers 2004;20(4-5):269-76.
2004: Wael M Abdel-Rahman; Päivi Peltomäki
Molecular basis and diagnostics of hereditary colorectal cancers.
Annals of medicine 2004;36(5):379-88.
2004: Heikki J Järvinen; Päivi Peltomäki
The complex genotype-phenotype relationship in familial adenomatous polyposis.
European journal of gastroenterology & hepatology 2004;16(1):5-8.
2004: Rainer Lehtonen; Maija Kiuru; Sakari Vanharanta; Jari Sjöberg; Leena-Maija Aaltonen; Kristiina Aittomäki; Johanna Arola; Ralf Butzow; Charis Eng; Kirsti Husgafvel-Pursiainen; Jorma Isola; Heikki Järvinen; Pasi A Koivisto; Jukka-Pekka Mecklin; Päivi Peltomäki; Reijo Salovaara; Veli-Matti Wasenius; Auli Karhu; Virpi Launonen; Nina N Nupponen; Lauri A Aaltonen
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.
The American journal of pathology 2004;164(1):17-22.
2003: Tuija Hienonen; Päivi Laiho; Reijo Salovaara; Jukka-Pekka Mecklin; Heikki Järvinen; Pertti Sistonen; Päivi Peltomäki; Rainer Lehtonen; Nina N Nupponen; Virpi Launonen; Auli Karhu; Lauri A Aaltonen
Little evidence for involvement of MLH3 in colorectal cancer predisposition.
International journal of cancer. Journal international du cancer 2003;106(2):292-6.
2003: Tiina E Raevaara; Carlos A Vaccaro; Wael M Abdel-Rahman; Esteban Mocetti; Shashi Bala; Karin E Lönnqvist; Reetta Kariola; Henry T Lynch; Päivi Peltomäki; Minna Nyström-Lahti
Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein.
Gastroenterology 2003;125(2):501-9.
2003: Carlos Sarroca; Päivi Peltomäki; Nora Alfano; Gladys Tedesco; Adriana Della Valle; Alejandra Dominguez; Henry T Lynch
Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay.
Cancer genetics and cytogenetics 2003;142(1):13-20.
2003: Päivi Peltomäki
Role of DNA mismatch repair defects in the pathogenesis of human cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(6):1174-9.
2002: Xiao-Ping Zhou; Anu Loukola; Reijo Salovaara; Minna Nystrom-Lahti; Päivi Peltomäki; Albert de La Chapelle; Lauri A Aaltonen; Charis Eng
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.
The American journal of pathology 2002;161(2):439-47.
2002: Shannon Kuismanen; Anu-Liisa Moisio; Pascal Schweizer; Kaspar Truninger; Reijo Salovaara; Johanna Arola; Ralf Butzow; Josef Jiricny; Minna Nyström-Lahti; Päivi Peltomäki
Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.
The American journal of pathology 2002;160(6):1953-8.
2002: Anu-Liisa Moisio; Heikki Järvinen; Päivi Peltomäki
Genetic and clinical characterisation of familial adenomatous polyposis: a population based study.
Gut 2002;50(6):845-50.
2002: Sigrid M Kraggerud; Rolf Skotheim; Jadwiga Szymanska; Mette Eknaes; Sophie D Fosså; Anna E Stenwig; Päivi Peltomäki; Ragnhild A Lothe
Genome profiles of familial/bilateral and sporadic testicular germ cell tumors.
Genes, chromosomes & cancer 2002;34(2):168-74.
2002: Dominic J Smiraglia; Jadwiga Szymanska; Sigrid M Kraggerud; Ragnhild A Lothe; Päivi Peltomäki; Christoph Plass
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors.
Oncogene 2002;21(24):3909-16.
2001: T Liu; H Yan; Shannon Kuismanen; Antonio Percesepe; Marie-Luise Bisgaard; Monica Pedroni; Piero Benatti; Kenneth W Kinzler; Bert Vogelstein; Maurizio Ponz de Leon; Päivi Peltomäki; Annika Lindblom
The role of hPMS1 and hPMS2 in predisposing to colorectal cancer.
Cancer research 2001;61(21):7798-802.
2001: Antonio Percesepe; Francesca Borghi; Mirco Menigatti; Lorena Losi; M Foroni; Carmela Di Gregorio; Giuseppe Rossi; Monica Pedroni; E Sala; Fabiana Vaccina; Luca Roncucci; Piero Benatti; Alessandra Viel; Maurizio Genuardi; Giancarlo Marra; Paula Kristo; Päivi Peltomäki; Maurizio Ponz de Leon
Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(19):3944-50.
2001: T Liu; J Chen; Sima Salahshor; Shannon Kuismanen; E Holmberg; H Grönberg; Päivi Peltomäki; Annika Lindblom
Screening families with endometrial and colorectal cancers for germline mutations.
Journal of medical genetics 2001;38(9):E29.
2001: Shashi Bala; Päivi Peltomäki
CYCLIN D1 as a genetic modifier in hereditary nonpolyposis colorectal cancer.
Cancer research 2001;61(16):6042-5.
2001: Pascal Schweizer; Anu-Liisa Moisio; Shannon Kuismanen; Kaspar Truninger; R Vierumäki; Reijo Salovaara; Johanna Arola; Ralf Butzow; Josef Jiricny; Päivi Peltomäki; Minna Nyström-Lahti
Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer.
Cancer research 2001;61(7):2813-5.
2001: Päivi Peltomäki
Deficient DNA mismatch repair: a common etiologic factor for colon cancer.
Human molecular genetics 2001;10(7):735-40.
2001: Päivi Peltomäki
DNA mismatch repair and cancer.
Mutation research 2001;488(1):77-85.
2001: J Huang; Shannon Kuismanen; T Liu; RB Chadwick; CK Johnson; MW Stevens; S K Richards; JE Meek; X Gao; Fred A Wright; Jukka-Pekka Mecklin; H J Järvinen; H Grönberg; Marie-Luise Bisgaard; Annika Lindblom; Päivi Peltomäki
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.
Cancer research 2001;61(4):1619-23.
2001: Päivi Peltomäki; X Gao; Jukka-Pekka Mecklin
Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations.
Familial cancer 2001;1(1):9-15.
2000: Sigrid M Kraggerud; Jadwiga Szymanska; Vera M Abeler; Janne Kaern; Mette Eknaes; Sverre Heim; Manuel Teixeira; Claes G Tropé; Päivi Peltomäki; Ragnhild A Lothe
DNA copy number changes in malignant ovarian germ cell tumors.
Cancer research 2000;60(11):3025-30.
2000: Shannon Kuismanen; MT Holmberg; Reijo Salovaara; Albert de La Chapelle; Päivi Peltomäki
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.
The American journal of pathology 2000;156(5):1773-9.
2000: Heikki J Järvinen; Markku T Aarnio; Harri Mustonen; Katja Aktan-Collan; Lauri A Aaltonen; Päivi Peltomäki; Albert de La Chapelle; Jukka-Pekka Mecklin
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer.
Gastroenterology 2000;118(5):829-34.
2000: S Roth; M Johansson; Anu Loukola; Päivi Peltomäki; Heikki Järvinen; Jukka-Pekka Mecklin; Lauri A Aaltonen
Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal.
Journal of medical genetics 2000;37(4):298-300.
2000: Antonio Percesepe; Monica Pedroni; E Sala; Mirco Menigatti; Francesca Borghi; Lorena Losi; Alessandra Viel; Maurizio Genuardi; Piero Benatti; Luca Roncucci; Päivi Peltomäki; Maurizio Ponz de Leon
Genomic instability and target gene mutations in colon cancers with different degrees of allelic shifts.
Genes, chromosomes & cancer 2000;27(4):424-9.
2000: Carlos Sarroca; N Alfano; G T Bendin; A Della Valle; A Dominguez; Roberto Quadrelli; Alicia Vaglio; Búrix Mechoso; Susan Tinley; AE Harty; Jane F Lynch; BA Franklin; Paula Kristo; T C Smyrk; Päivi Peltomäki; Henry T Lynch
Hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay.
Diseases of the colon and rectum 2000;43(3):353-60; discussion 360-2.
2000: Katja Aktan-Collan; Jukka-Pekka Mecklin; Albert de La Chapelle; Päivi Peltomäki; Antti Uutela; Helena Kääriäinen
Evaluation of a counselling protocol for predictive genetic testing for hereditary non-polyposis colorectal cancer.
Journal of medical genetics 2000;37(2):108-13.
2000: Katja Aktan-Collan; Jukka-Pekka Mecklin; Heikki Järvinen; Minna Nyström-Lahti; Päivi Peltomäki; I Söderling; Antti Uutela; Albert de La Chapelle; Helena Kääriäinen
Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.
International journal of cancer. Journal international du cancer 2000;89(1):44-50.
2000: Jukka-Pekka Mecklin; Päivi Peltomäki
Genetic changes associated with colon tumor development.
Annales chirurgiae et gynaecologiae 2000;89(3):211-5.
1999: Minna Nyström-Lahti; MT Holmberg; P Fidalgo; Reijo Salovaara; Albert de La Chapelle; Josef Jiricny; Päivi Peltomäki
Missense and nonsense mutations in codon 659 of MLH1 cause aberrant splicing of messenger RNA in HNPCC kindreds.
Genes, chromosomes & cancer 1999;26(4):372-5.
1999: Shannon Kuismanen; MT Holmberg; Reijo Salovaara; Pascal Schweizer; Lauri A Aaltonen; Albert de La Chapelle; Minna Nyström-Lahti; Päivi Peltomäki
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12661-6.
1999: Dominic J Smiraglia; Michael C Frühwald; Joseph F Costello; S P McCormick; Zunyan Dai; Päivi Peltomäki; M Sue O'Dorisio; Webster K Cavenee; Christoph Plass
A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels.
Genomics 1999;58(3):254-62.
1999: Markku T Aarnio; Risto Sankila; Eero Pukkala; Reijo Salovaara; Lauri A Aaltonen; Albert de La Chapelle; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki J Järvinen
Cancer risk in mutation carriers of DNA-mismatch-repair genes.
International journal of cancer. Journal international du cancer 1999;81(2):214-8.
1999: Päivi Peltomäki
The genetics of hereditary non-polyposis colorectal cancer and non-polypotic colon cancer.
Advances in experimental medicine and biology 1999;470():95-8.
1998: Anu-Liisa Moisio; Pertti Sistonen; Jukka-Pekka Mecklin; Heikki Järvinen; Päivi Peltomäki
Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.
Gastroenterology 1998;115(6):1387-94.
1998: Antonio Percesepe; Paula Kristo; Lauri A Aaltonen; Maurizio Ponz de Leon; Albert de La Chapelle; Päivi Peltomäki
Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability.
Oncogene 1998;17(2):157-63.
1998: Lauri A Aaltonen; Reijo Salovaara; Paula Kristo; F Canzian; Akseli Hemminki; Päivi Peltomäki; R B Chadwick; Helena Kääriäinen; Matti Eskelinen; Heikki Järvinen; Jukka-Pekka Mecklin; Albert de La Chapelle
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.
The New England journal of medicine 1998;338(21):1481-7.
1998: MT Holmberg; Paula Kristo; R B Chadwicks; Jukka-Pekka Mecklin; Heikki Järvinen; Albert de La Chapelle; Minna Nyström-Lahti; Päivi Peltomäki
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online.
Human mutation 1998;11(6):482.
1997: Päivi Peltomäki; Hans Vasen
Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer.
Gastroenterology 1997;113(4):1146-58.
1997: Päivi Peltomäki
DNA mismatch repair gene mutations in human cancer.
Environmental health perspectives 1997;105 Suppl 4():775-80.
1997: Ying Wu; Minna Nyström-Lahti; Jan Osinga; M W G Looman; Päivi Peltomäki; Lauri A Aaltonen; Albert de La Chapelle; Robert M W Hofstra; Charles H C M Buys
MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis.
Genes, chromosomes & cancer 1997;18(4):269-78.
1997: Aslaug Helland; Anne-Lise Børresen-Dale; Päivi Peltomäki; Merete Hektoen; Gunnar Kristensen; Jahn M Nesland; ALBERT DE LA CHAPELLE; Ragnhild A Lothe
Microsatellite instability in cervical and endometrial carcinomas.
International journal of cancer. Journal international du cancer 1997;70(5):499-501.
1997: Siobhan S Wahlberg; Minna Nyström-Lahti; Michael F Kane; Richard D Kolodner; Päivi Peltomäki; Annika Lindblom
Low frequency of hMSH2 mutations in Swedish HNPCC families.
International journal of cancer. Journal international du cancer 1997;74(1):134-7.
1997: Päivi Peltomäki; Albert de La Chapelle
Mutations predisposing to hereditary nonpolyposis colorectal cancer.
Advances in cancer research 1997;71():93-119.
1996: Anu-Liisa Moisio; Pertti Sistonen; J Weissenbach; Albert de La Chapelle; Päivi Peltomäki
Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.
American journal of human genetics 1996;59(6):1243-51.
1996: Minna Nyström-Lahti; Y Wu; Anu-Liisa Moisio; Robert M W Hofstra; Jan Osinga; Jukka-Pekka Mecklin; Heikki J Järvinen; Jaakko Leisti; Charles H C M Buys; Albert de La Chapelle; Päivi Peltomäki
DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer.
Human molecular genetics 1996;5(6):763-9.
1996: B Liu; R Parsons; Nickolas Papadopoulos; N C Nicolaides; H T Lynch; P Watson; J R Jass; M Dunlop; Andrew H Wyllie; Päivi Peltomäki; ALBERT DE LA CHAPELLE; Stanley R Hamilton; Bert Vogelstein; Kenneth W Kinzler
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients.
Nature medicine 1996;2(2):169-74.
1996: Anu-Liisa Moisio; Päivi Peltomäki
[The mismatch-repair genes and colon cancer].
Duodecim; lääketieteellinen aikakauskirja 1996;112(4):337-40.
1995: P Salo; Helena Kääriäinen; V Petrovic; Päivi Peltomäki; D C Page; Albert de La Chapelle
Molecular mapping of the putative gonadoblastoma locus on the Y chromosome.
Genes, chromosomes & cancer 1995;14(3):210-4.
1995: Ragnhild A Lothe; Solveig Norheim Andersen; Bjørn Hofstad; Gunn Iren Meling; Päivi Peltomäki; Sverre Heim; A Brøgger; Morten Vatn; Torleiv O Rognum; A L Børresen
Deletion of 1p loci and microsatellite instability in colorectal polyps.
Genes, chromosomes & cancer 1995;14(3):182-8.
1995: Ragnhild A Lothe; Päivi Peltomäki; Niels Tommerup; Sophie D Fosså; Anna E Stenwig; A L Børresen; Jahn M Nesland
Molecular genetic changes in human male germ cell tumors.
Laboratory investigation; a journal of technical methods and pathology 1995;73(5):606-14.
1995: Raquel Seruca; Nuno R. dos Santos; Leonor David; M Constância; helena barroca; Fátima Carneiro; Mário Seixas; Päivi Peltomäki; Ragnhild A Lothe; Manuel Sobrinho-Simões
Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile.
International journal of cancer. Journal international du cancer 1995;64(1):32-6.
1995: Albert de La Chapelle; Päivi Peltomäki
Genetics of hereditary colon cancer.
Annual review of genetics 1995;29():329-48.
1995: B Liu; N C Nicolaides; Sanford Markowitz; James Willson; R E Parsons; Jin Jen; N Papadopolous; Päivi Peltomäki; ALBERT DE LA CHAPELLE; Stanley R Hamilton
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability.
Nature genetics 1995;9(1):48-55.
1994: Akseli Hemminki; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki Järvinen; Reijo Salovaara; Minna Nyström-Lahti; Albert de La Chapelle; Lauri A Aaltonen
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer.
Nature genetics 1994;8(4):405-10.
1994: Henry T Lynch; T Drouhard; Stephen J Lanspa; Thomas C Smyrk; P Lynch; J Lynch; Bert Vogelstein; Minna Nyström-Lahti; Pertti Sistonen; Päivi Peltomäki
Mutation of an mutL homologue in a Navajo family with hereditary nonpolyposis colorectal cancer.
Journal of the National Cancer Institute 1994;86(18):1417-9.
1994: Lauri A Aaltonen; Päivi Peltomäki
Genes involved in hereditary nonpolyposis colorectal carcinoma.
Anticancer research 1994;14(4B):1657-60.
1994: Minna Nyström-Lahti; Pertti Sistonen; Jukka-Pekka Mecklin; Liisa Pylkkänen; Lauri A Aaltonen; Heikki Järvinen; J Weissenbach; Albert de La Chapelle; Päivi Peltomäki
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6054-8.
1994: Päivi Peltomäki
Genetic basis of hereditary nonpolyposis colorectal carcinoma (HNPCC).
Annals of medicine 1994;26(3):215-9.
1994: Juha Klefstrom; Kaarle Franssila; Päivi Peltomäki; M Kaartinen; Marja-Liisa Solin; Sakari Knuutila
Major and minor breakpoint sites of chromosomal translocation t(14;18) in subtypes of non-Hodgkin's lymphomas.
Leukemia research 1994;18(4):245-50.
1994: Lauri A Aaltonen; Päivi Peltomäki; Jukka-Pekka Mecklin; Heikki Järvinen; J R Jass; J S Green; H T Lynch; P Watson; G Tallqvist; M Juhola
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.
Cancer research 1994;54(7):1645-8.
1994: Sakari Knuutila; J Klefström; J Szymanska; T Lakkala; Päivi Peltomäki; M Eray; Lasse Teerenhovi; Erkki Elonen; Kaarle Franssila; M Kaartinen
Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation.
European journal of haematology 1994;52(2):65-72.
1994: Lauri A Aaltonen; Risto Sankila; Jukka-Pekka Mecklin; Heikki Järvinen; Eero Pukkala; Päivi Peltomäki; Albert de La Chapelle
A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden.
Cancer detection and prevention 1994;18(1):57-63.
1993: F S Leach; N C Nicolaides; Nickolas Papadopoulos; B Liu; Jin Jen; R Parsons; Päivi Peltomäki; Pertti Sistonen; Lauri A Aaltonen; Minna Nyström-Lahti
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
Cell 1993;75(6):1215-25.
1993: Päivi Peltomäki; Ragnhild A Lothe; Lauri A Aaltonen; Liisa Pylkkänen; Minna Nyström-Lahti; Raquel Seruca; L David; R Holm; David Ryberg; Aage Haugen
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.
Cancer research 1993;53(24):5853-5.
1993: Ragnhild A Lothe; Päivi Peltomäki; Gunn Iren Meling; Lauri A Aaltonen; Minna Nyström-Lahti; Liisa Pylkkänen; Ketil Heimdal; Tone Ikdal Andersen; P Møller; Torleiv O Rognum
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.
Cancer research 1993;53(24):5849-52.
1993: Lauri A Aaltonen; Päivi Peltomäki; F S Leach; Pertti Sistonen; Liisa Pylkkänen; Jukka-Pekka Mecklin; Heikki Järvinen; Steven M Powell; Jin Jen; Stanley R Hamilton
Clues to the pathogenesis of familial colorectal cancer.
Science (New York, N.Y.) 1993;260(5109):812-6.
1993: Päivi Peltomäki; Lauri A Aaltonen; Pertti Sistonen; Liisa Pylkkänen; Jukka-Pekka Mecklin; Heikki Järvinen; J S Green; J R Jass; J L Weber; F S Leach
Genetic mapping of a locus predisposing to human colorectal cancer.
Science (New York, N.Y.) 1993;260(5109):810-2.
1993: Marcelo L Larramendy; M Heiskanen; Maija Wessman; A Ritvanen; Päivi Peltomäki; K Simola; Helena Kääriäinen; Harriet von Koskull; M Kähkönen; Sakari Knuutila
Molecular cytogenetic study of patients with Pallister-Killian syndrome.
Human genetics 1993;91(2):121-7.
1993: Päivi Peltomäki; L Aaltonen; Jukka-Pekka Mecklin; ALBERT DE LA CHAPELLE
[A breakthrough in solving the genetic background of colon cancer].
Duodecim; lääketieteellinen aikakauskirja 1993;109(16):1367-9.
1992: Päivi Peltomäki; Ragnhild A Lothe; A L Børresen; S D Fosså; A Brøgger; Albert de La Chapelle
Chromosome 12 in human testicular cancer: dosage changes and their parental origin.
Cancer genetics and cytogenetics 1992;64(1):21-6.
1992: Päivi Peltomäki; Pertti Sistonen; Jukka-Pekka Mecklin; Liisa Pylkkänen; Lauri A Aaltonen; S Nordling; Juha Kere; Heikki Järvinen; Stanley R Hamilton; G Petersen
Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma.
Cancer research 1992;52(16):4530-3.
1991: Päivi Peltomäki; Pertti Sistonen; Jukka-Pekka Mecklin; Liisa Pylkkänen; Heikki Järvinen; J W Simons; Kathleen R Cho; Bert Vogelstein; Albert de La Chapelle
Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds.
Cancer research 1991;51(16):4135-40.
1991: Päivi Peltomäki; O Alfthan; Albert de La Chapelle
Oncogenes in human testicular cancer: DNA and RNA studies.
British journal of cancer 1991;63(6):851-8.
1991: Päivi Peltomäki
DNA methylation changes in human testicular cancer.
Biochimica et biophysica acta 1991;1096(3):187-96.
1991: Päivi Peltomäki; Ragnhild A Lothe; A L Børresen; S D Fosså; A Brøgger; Albert de La Chapelle
Altered dosage of the sex chromosomes in human testicular cancer: a molecular genetic study.
International journal of cancer. Journal international du cancer 1991;47(4):518-22.
1991: Päivi Peltomäki; H Järvinen; Albert de La Chapelle
[Early diagnosis and screening of colonic adenomatous polyposis].
Duodecim; lääketieteellinen aikakauskirja 1991;107(17):1405-9.
1990: P E Kovanen; Kaarle Franssila; Päivi Peltomäki; Sakari Knuutila
Effect of a low-molecular-weight B cell growth factor on the proliferation of normal and neoplastic lymphocytes in lymphomas.
Cancer genetics and cytogenetics 1990;48(1):109-18.
1990: Päivi Peltomäki; A Halme; Albert de La Chapelle
Human testicular cancer. Changes in autosomal dosage.
Cancer genetics and cytogenetics 1990;48(1):1-12.
1990: Marcelo L Larramendy; Päivi Peltomäki; E Salonen; Sakari Knuutila
Chromosomal abnormality limited to T4 lymphocytes in a patient with T-cell chronic lymphocytic leukaemia.
European journal of haematology 1990;45(1):52-9.
1990: J Klefström; M Kaartinen; Päivi Peltomäki; Marja-Liisa Solin; Kaarle Franssila; Sakari Knuutila
[The use of polymerase chain reaction in the diagnosis of non-Hodgkin's lymphoma].
Duodecim; lääketieteellinen aikakauskirja 1990;106(23-24):1645-53.
1989: C Lindholm; Kaarle Franssila; Lasse Teerenhovi; Erkki Elonen; Päivi Peltomäki; J Rapola; Tapani Ruutu; UM Saarinen; Sakari Knuutila
Characterization of neoplastic and reactive cells in T-cell lymphomas with cytogenetic, surface marker, and DNA methods.
British journal of haematology 1989;73(1):68-75.
1989: Päivi Peltomäki; A Halme; Albert de La Chapelle
Molecular studies of the sex chromosomes in human testicular cancer: pronounced changes in X and Y chromosome dosage in some tumors.
Genes, chromosomes & cancer 1989;1(1):42-7.
1988: Päivi Peltomäki; N O Bianchi; Sakari Knuutila; Lasse Teerenhovi; Erkki Elonen; R Leskinen; Albert de La Chapelle
Immunoglobulin kappa and lambda light chain dual genotype rearrangement in a patient with kappa-secreting B-CLL.
European journal of cancer & clinical oncology 1988;24(7):1233-8.