FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Leena Peltonen

Research Profile

Geographic Areas

Finland

Procedures

Chromosome Mapping

Chemicals & Drugs

Concepts & Ideas

Physiology

Genes & Molecular Sequences

Disorders

Co-author Network

Publications

TOP 3
Pirkka-Pekka Laurila; Terho Lehtimäki; Daniel B Mirel; Jussi Naukkarinen; Matej Oresic; Aarno Palotie; Leena Peltonen; Olli T Raitakari; Aimo Ruokonen; Veikko Salomaa; Antti-Pekka Sarin; Sanni Söderlund; Jarkko Soronen; Ida Surakka; Jing Tang; Marja-Riitta Taskinen; Laxman Yetukuri; Christian Ehnholm; Johan G Eriksson; Tuulia Hyötyläinen; Marjo-Riitta Järvelin; Matti Jauhiainen; Antti Jula; Johannes Kettunen; Samuli Ripatti
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Ida Surakka; Ann-Christine Syvänen; Peter M Visscher; John B Whitfield; Elisabeth Widén; Gonneke Willemsen; Dorret I Boomsma; Kaare Christensen; Eco J C De Geus; Mario Falchi; Jaakko Kaprio; Kirsten O Kyvik; Ulrika Liljedahl; Patrik K E Magnusson; Nicholas G Martin; Grant W Montgomery; Juha Muilu; Aarno Palotie; Nancy L Pedersen; Leena Peltonen; Markus Perola; Kirsi H Pietiläinen; Iffat Rahman; Taina Rantanen; Samuli Ripatti; Kaisa Silander; Thorkild I A Sørensen; Tim Spector
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
Ruzica Kolakovic; Antti Laukkanen; Leena Peltonen; Jouni Hirvonen; Timo Laaksonen
Nanofibrillar cellulose films for controlled drug delivery.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Leena Peltonen (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Pirkka-Pekka Laurila; Terho Lehtimäki; Daniel B Mirel; Jussi Naukkarinen; Matej Oresic; Aarno Palotie; Leena Peltonen; Olli T Raitakari; Aimo Ruokonen; Veikko Salomaa; Antti-Pekka Sarin; Sanni Söderlund; Jarkko Soronen; Ida Surakka; Jing Tang; Marja-Riitta Taskinen; Laxman Yetukuri; Christian Ehnholm; Johan G Eriksson; Tuulia Hyötyläinen; Marjo-Riitta Järvelin; Matti Jauhiainen; Antti Jula; Johannes Kettunen; Samuli Ripatti
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):847-57.
2012: Ida Surakka; Ann-Christine Syvänen; Peter M Visscher; John B Whitfield; Elisabeth Widén; Gonneke Willemsen; Dorret I Boomsma; Kaare Christensen; Eco J C De Geus; Mario Falchi; Jaakko Kaprio; Kirsten O Kyvik; Ulrika Liljedahl; Patrik K E Magnusson; Nicholas G Martin; Grant W Montgomery; Juha Muilu; Aarno Palotie; Nancy L Pedersen; Leena Peltonen; Markus Perola; Kirsi H Pietiläinen; Iffat Rahman; Taina Rantanen; Samuli Ripatti; Kaisa Silander; Thorkild I A Sørensen; Tim Spector
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2012;15(6):691-9.
2012: Ruzica Kolakovic; Antti Laukkanen; Leena Peltonen; Jouni Hirvonen; Timo Laaksonen
Nanofibrillar cellulose films for controlled drug delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;82(2):308-15.
2012: Luis Bimbo; Jouni Hirvonen; Leena Peltonen; Helder A Santos
Toxicological profile of therapeutic nanodelivery systems.
Current drug metabolism 2012;13(8):1068-86.
2012: A S Parmar; Leena Peltonen; P Saavalainen; V Salomaa; Leif Törkvist; Ulla Turunen; Markus Färkkilä; Jonas Halfvarson; Leena Halme; Kimmo Kontula; Maija Lappalainen; Paulina Paavola-Sakki; A Aromaa; Mauro D'Amato; E Einarsdottir
Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients.
Genes and immunity 2012;13(6):474-80.
2012: Emma S Nyman; Susan L Smalley; Anja Taanila; Teppo Varilo; Tuula Hurtig; Marjo-Riitta Järvelin; Sandra Loo; Anu Loukola; James J McGough; Irma Moilanen; Stanley F Nelson; Leena Peltonen
Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort.
Psychiatric genetics 2012;22(4):197-201.
2012: Ruzica Kolakovic; Timo Laaksonen; Antti Laukkanen; Leena Peltonen; Jouni Hirvonen
Spray-dried nanofibrillar cellulose microparticles for sustained drug release.
International journal of pharmaceutics 2012;430(1-2):47-55.
2012: Annukka Marjamaa; Christopher Newton-Cheh; Markku S Nieminen; Peter A Noseworthy; Christopher J O'Donnell; Lasse Oikarinen; Gina Peloso; Leena Peltonen; Markus Perola; Kimmo Porthan; Samuli Ripatti; Aki S Havulinna; Antti Jula; Kimmo Kontula; Lauri Toivonen; Matti Viitasalo; Veikko Salomaa
A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(7):1099-103.
2012: Elisabeth Widén; Diana L Cousminer; Anna-Liisa Hartikainen; Marjo-Riitta Järvelin; Jaakko Kaprio; Jaana Laitinen; Leena Peltonen; Anneli Pouta; Samuli Ripatti; Karri Silventoinen; Ulla Sovio; Aarno Palotie
Pubertal timing and growth influences cardiometabolic risk factors in adult males and females.
Diabetes care 2012;35(4):850-6.
2012: Eliza Congdon; Marjo-Riitta Järvelin; Matti Joukamaa; Markku Koiranen; Heikki Mannila; Jouko Miettunen; Tiina Paunio; Leena Peltonen; Stefan Schönauer; Jouni K Seppänen; Susan Service; Hannu Turunen; Juha Veijola; Jaana Wessman; Nelson B Freimer
Early environment and neurobehavioral development predict adult temperament clusters.
PloS one 2012;7(7):e38065.
2012: Jaana Wessman; Eliza Congdon; Jesper Ekelund; Nelson B Freimer; Mirka Hintsanen; Marjo-Riitta Järvelin; Matti Joukamaa; Liisa Keltikangas-Järvinen; Markku Koiranen; Jaana Laitinen; Heikki Mannila; Jouko Miettunen; Pekka Parviainen; Leena Peltonen; Laura Pulkki-Råback; Olli T Raitakari; Stefan Schönauer; Jouni K Seppänen; Susan Service; Anja Taanila; Tuija Tammelin; Hannu Turunen; Juha Veijola; Jorma Viikari; Tiina Paunio
Temperament clusters in a normal population: implications for health and disease.
PloS one 2012;7(7):e33088.
2011: Hanna Valo; Markus Linder; Leena Peltonen; Seppo Auriola; Merja Häkkinen; Jouni Hirvonen; Kristiina Järvinen; Miia Kovalainen; Päivi Laaksonen; Timo Laaksonen
Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices--enhanced stability and release.
Journal of controlled release : official journal of the Controlled Release Society 2011;156(3):390-7.
2011: Mervi Oikonen; Leena Peltonen; Gerald S Berenson; Wei Chen; Aki S Havulinna; Jonna Juhola; Markus Juonala; Mika Kähönen; Frank Kee; Terho Lehtimäki; Vera Mikkilä; Sarah S Murray; Christopher Newton-Cheh; Samuli Ripatti; Veikko Salomaa; Nicholas J Schork; Ilkka Seppälä; Sathanur R Srinivasan; Leena Taittonen; Emmi Tikkanen; Tarja Tuovinen; Jorma Viikari; Olli T Raitakari
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study.
Hypertension 2011;58(6):1079-85.
2011: Ruzica Kolakovic; Timo Laaksonen; Antti Laukkanen; Leena Peltonen; Kaisa Putkisto; Jouni Hirvonen
Spray-dried cellulose nanofibers as novel tablet excipient.
AAPS PharmSciTech 2011;12(4):1366-73.
2011: Timo Laaksonen; Peng Liu; Leena Peltonen; Antti Rahikkala; Jouni Hirvonen; Kristiina Järvinen; Esko I Kauppinen; Janne Raula
Intact nanoparticulate indomethacin in fast-dissolving carrier particles by combined wet milling and aerosol flow reactor methods.
Pharmaceutical research 2011;28(10):2403-11.
2011: Tarja Limnell; Marjatta Louhi-Kultanen; Dmitry Yu Murzin; Leena Peltonen; Jarno Salonen; Hélder A Santos; Sanna Sistonen; Teemu Heikkilä; Sanna Hellstén; Jouni Hirvonen; Narendra Kumar; Timo Laaksonen; Vesa-Pekka Lehto
Physicochemical stability of high indomethacin payload ordered mesoporous silica MCM-41 and SBA-15 microparticles.
International journal of pharmaceutics 2011;416(1):242-51.
2011: Tarja Limnell; Ermei Mäkilä; Dmitry Yu Murzin; Leena Peltonen; Jarno Salonen; Hélder A Santos; Teemu Heikkilä; Narendra Kumar; Timo Laaksonen; Jouni Hirvonen
Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods.
Journal of pharmaceutical sciences 2011;100(8):3294-306.
2011: Annukka M Lahtinen; Eero Lehtonen; Annukka Marjamaa; Lasse Oikarinen; Aarno Palotie; Leena Peltonen; Kimmo Porthan; Veikko Salomaa; Heikki Swan; Lauri Toivonen; Tiina Heliö; Antti Jula; Maija Kaartinen; Kimmo Kontula
Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(8):1214-21.
2011: Paula Lehto; Anni Liimatainen; Krista Ojala; Jouni Hirvonen; Heli Kangas; Hanna Kortejärvi; Veli Pekka Tanninen; Leena Peltonen
Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;78(3):531-8.
2011: Olli P H Pietiläinen; Karola Rehnström; Samuli Ripatti; Chiara Sabatti; Susan K Service; Anja Taanila; Carola Gabriella Tilgmann; Eliza Congdon; Nelson B Freimer; Anna-Liisa Hartikainen; Ulla Heikura; Matti Isohanni; Eveliina Jakkula; Marjo-Riitta Jarvelin; Aarno Palotie; Tiina Paunio; Leena Peltonen
Phenotype mining in CNV carriers from a population cohort.
Human molecular genetics 2011;20(13):2686-95.
2011: Peng Liu; Xinyu Rong; Johanna Laru; Bert van Veen; Juha Kiesvaara; Jouni Hirvonen; Timo Laaksonen; Leena Peltonen
Nanosuspensions of poorly soluble drugs: preparation and development by wet milling.
International journal of pharmaceutics 2011;411(1-2):215-22.
2011: Emma Nyman; Jouko Miettunen; Nelson Freimer; Matti Joukamaa; Pirjo Mäki; Jesper Ekelund; Leena Peltonen; Marjo-Riitta Järvelin; Juha Veijola; Tiina Paunio
Impact of temperament on depression and anxiety symptoms and depressive disorder in a population-based birth cohort.
Journal of affective disorders 2011;131(1-3):393-7.
2011: Jouko Miettunen; Juha Veijola; Matti Isohanni; Tiina Paunio; Nelson Freimer; Erika Jääskeläinen; Anja Taanila; Jesper Ekelund; Marjo-Riitta Järvelin; Leena Peltonen; Matti Joukamaa; Dirk Lichtermann
Identifying schizophrenia and other psychoses with psychological scales in the general population.
The Journal of nervous and mental disease 2011;199(4):230-8.
2011: George F Mells; James A B Floyd; Katherine I Morley; Heather J Cordell; Christopher S Franklin; So-Youn Shin; Michael A Heneghan; James M Neuberger; Peter T Donaldson; Darren B Day; Samantha J Ducker; Agnes W Muriithi; Elizabeth F Wheater; Christopher J Hammond; Muhammad F Dawwas; David E Jones; Leena Peltonen; Graeme J Alexander; Richard N Sandford; Carl A Anderson
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
Nature genetics 2011;43(4):329-32.
2011: Annu Näkki; Tapio Videman; Urho M Kujala; Matti Suhonen; Minna Männikkö; Leena Peltonen; Michele C Battié; Jaakko Kaprio; Janna Saarela
Candidate gene association study of magnetic resonance imaging-based hip osteoarthritis (OA): evidence for COL9A2 gene as a common predisposing factor for hip OA and lumbar disc degeneration.
The Journal of rheumatology 2011;38(4):747-52.
2011: Teemu Heikkilä; Milja Karjalainen; Krista Ojala; Kirsi Partola; Frank Lammert; Patrick Augustijns; Arto Urtti; Marjo Yliperttula; Leena Peltonen; Jouni Hirvonen
Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid.
International journal of pharmaceutics 2011;405(1-2):132-6.
2011: Emma S Nyman; Nelson Freimer; Marjo-Riitta Järvelin; Matti Joukamaa; Virpi Leppä; Anu Loukola; Pirjo Mäki; Jouko Miettunen; Leena Peltonen; Pia Soronen; Sonja Sulkava; Juha Veijola; Tiina Paunio
Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort.
BMJ open 2011;1(1):e000087.
2011: Maija Wessman; Carol Forsblom; Per-Henrik Groop; Samy HADJADJ; Tero Hiekkalinna; Jorma Ilonen; Mari A Kaunisto; Michel Marre; Alexander P Maxwell; Maija Parkkonen; Hans-Henrik Parving; Leena Peltonen; Riitta Sallinen; Jenny Söderlund; Lise Tarnow
Novel susceptibility locus at 22q11 for diabetic nephropathy in type 1 diabetes.
PloS one 2011;6(9):e24053.
2011: Ritva Haataja; Minna K Karjalainen; Aino Luukkonen; Kari Teramo; Hilkka Puttonen; Marja Ojaniemi; Teppo Varilo; Bimal P Chaudhari; Jevon Plunkett; Jeffrey C Murray; Steven A McCarroll; Leena Peltonen; Louis J Muglia; Aarno Palotie; Mikko Hallman
Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis.
PLoS genetics 2011;7(2):e1001293.
2010: Monica Leu; Keith Humphreys; Ida Surakka; Emil Rehnberg; Juha Muilu; Päivi Rosenström; Peter Almgren; Juha Jääskeläinen; Richard P Lifton; Kirsten Ohm Kyvik; Jaakko Kaprio; Nancy L Pedersen; Aarno Palotie; Per Hall; Henrik Grönberg; Leif Groop; Leena Peltonen; Juni Palmgren; Samuli Ripatti
NordicDB: a Nordic pool and portal for genome-wide control data.
European journal of human genetics : EJHG 2010;18(12):1322-6.
2010: Leena Peltonen; Jouni Hirvonen
Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods.
The Journal of pharmacy and pharmacology 2010;62(11):1569-79.
2010: Samuli Ripatti; Emmi Tikkanen; Marju Orho-Melander; Aki S Havulinna; Kaisa Silander; Amitabh Sharma; Candace Guiducci; Markus Perola; Antti Jula; Juha Sinisalo; Marja-Liisa Lokki; Markku S Nieminen; Olle Melander; Veikko Salomaa; Leena Peltonen; Sekar Kathiresan
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
Lancet 2010;376(9750):1393-400.
2010: Ida Surakka; Kati Kristiansson; Verneri Anttila; Michael Inouye; Chris Barnes; Loukas Moutsianas; Veikko Salomaa; Mark J Daly; Aarno Palotie; Leena Peltonen; Samuli Ripatti
Founder population-specific HapMap panel increases power in GWA studies through improved imputation accuracy and CNV tagging.
Genome research 2010;20(10):1344-51.
2010: Erin N Smith; Wei Chen; Mika Kähönen; Johannes Kettunen; Terho Lehtimäki; Leena Peltonen; Olli T Raitakari; Rany M Salem; Nicholas J Schork; Marian Shaw; Sathanur R Srinivasan; Eric J Topol; Jorma S Viikari; Gerald S Berenson; Samuel S Murray
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
PLoS genetics 2010;6(9):.
2010: Jonas Donner; Rita Haapakoski; Sini Ezer; Erik Melén; sami pirkola; Mònica Gratacòs; Marco Zucchelli; Francesca Anedda; Lovisa E Johansson; Cilla Söderhäll; Christina Orsmark-Pietras; Jaana Suvisaari; Rocío Martín-Santos; Marta Torrens; Kaisa Silander; Joseph D Terwilliger; Magnus Wickman; Göran Pershagen; Jouko Lönnqvist; Leena Peltonen; Xavier Estivill; Mauro D'Amato; Juha Kere; Harri Alenius; Iiris Hovatta
Assessment of the neuropeptide S system in anxiety disorders.
Biological psychiatry 2010;68(5):474-83.
2010: K M Lampi; Andre Sourander; M Gissler; S Niemelä; K Rehnström; E Pulkkinen; Leena Peltonen; Lennart von Wendt
Brief report: validity of Finnish registry-based diagnoses of autism with the ADI-R.
Acta paediatrica (Oslo, Norway : 1992) 2010;99(9):1425-8.
2010: Hélder A. Santos; Joakim Riikonen; Jarno Salonen; Ermei Mäkilä; Teemu Heikkilä; Timo Laaksonen; Leena Peltonen; Vesa-Pekka Lehto; Jouni Hirvonen
In vitro cytotoxicity of porous silicon microparticles: effect of the particle concentration, surface chemistry and size.
Acta biomaterialia 2010;6(7):2721-31.
2010: Luis Bimbo; Mirkka Sarparanta; Hélder A Santos; Anu J Airaksinen; Ermei Mäkilä; Timo Laaksonen; Leena Peltonen; Vesa-Pekka Lehto; Hélder A. Santos; Jarno Salonen
Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats.
ACS nano 2010;4(6):3023-32.
2010: Tessa Sipilä; Laura Kananen; Dario Greco; Jonas Donner; Kaisa Silander; Joseph D Terwilliger; Petri Auvinen; Leena Peltonen; Jouko Lönnqvist; sami pirkola; Timo Partonen; Iiris Hovatta
An association analysis of circadian genes in anxiety disorders.
Biological psychiatry 2010;67(12):1163-70.
2010: Jussi Naukkarinen; Ida Surakka; Kirsi H Pietiläinen; Aila Rissanen; Veikko Salomaa; Samuli Ripatti; Hannele Yki-Järvinen; Cornelia M van Duijn; H-Erich Wichmann; Jaakko Kaprio; Marja-Riitta Taskinen; Leena Peltonen
Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
PLoS genetics 2010;6(6):e1000976.
2010: Leena Peltonen; Hanna Valo; Ruzica Kolakovic; Timo Laaksonen; Jouni Hirvonen
Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles.
Expert opinion on drug delivery 2010;7(6):705-19.
2010: Juho Wedenoja; Annamari Tuulio-Henriksson; Jaana Suvisaari; Anu Loukola; Tiina Paunio; Timo Partonen; Teppo Varilo; Jouko Lönnqvist; Leena Peltonen
Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia.
Biological psychiatry 2010;67(10):983-91.
2010: Elisabeth Widén; Samuli Ripatti; Diana Cousminer; Ida Surakka; Tuuli Lappalainen; Marjo-Riitta Järvelin; Johan G Eriksson; Olli Raitakari; Veikko Salomaa; Ulla Sovio; Anna-Liisa Hartikainen; Anneli Pouta; Mark I McCarthy; Clive Osmond; Eero Kajantie; Terho Lehtimäki; Jorma Viikari; Mika Kähönen; Chris Tyler-Smith; Nelson Freimer; Joel N Hirschhorn; Leena Peltonen; Aarno Palotie
Distinct variants at LIN28B influence growth in height from birth to adulthood.
American journal of human genetics 2010;86(5):773-82.
2010: Sarah E Medland; Tetyana Zayats; Beate Glaser; Dale R Nyholt; Scott D Gordon; Margaret J Wright; Grant W Montgomery; Megan J Campbell; Anjali K Henders; Nicholas J Timpson; Leena Peltonen; Dieter Wolke; Susan M Ring; Panos Deloukas; Nicholas G Martin; George Davey Smith; David M Evans
A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure.
American journal of human genetics 2010;86(4):519-25.
2010: Outi M Palo; Pia Soronen; Kaisa Silander; Teppo Varilo; Katja Tuononen; Tuula Kieseppä; Timo Partonen; Jouko Lönnqvist; Tiina Paunio; Leena Peltonen
Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(3):723-35.
2010: Teemu Heikkilä; Hélder A. Santos; Narendra Kumar; Dmitry Yu Murzin; Jarno Salonen; Timo Laaksonen; Leena Peltonen; Jouni Hirvonen; Vesa-Pekka Lehto
Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2010;74(3):483-94.
2010: Eveliina Jakkula; Virpi Leppä; Anna-Maija Sulonen; Teppo Varilo; Suvi Kallio; Anu Kemppinen; Shaun Purcell; Keijo Koivisto; Pentti J Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Arpo Aromaa; Annette Bang Oturai; Helle Bach Søndergaard; Hanne F Harbo; Inger-Lise Mero; Stacey B Gabriel; Daniel B Mirel; Stephen L Hauser; Ludwig Kappos; Chris Polman; Philip L De Jager; David A Hafler; Mark J Daly; Aarno Palotie; Janna Saarela; Leena Peltonen
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
American journal of human genetics 2010;86(2):285-91.
2010: Demetris Pillas; Clive J Hoggart; David M Evans; Paul F O'Reilly; Kirsi Sipilä; Raija Lähdesmäki; Iona Y Millwood; Marika Kaakinen; Gopalakrishnan Netuveli; David Blane; Pimphen Charoen; Ulla Sovio; Anneli Pouta; Nelson B Freimer; Anna-Liisa Hartikainen; Jaana Laitinen; Sarianna Vaara; Beate Glaser; Peter Crawford; Nicholas J Timpson; Susan M Ring; Guohong Deng; Weihua Zhang; Mark I McCarthy; Panos Deloukas; Leena Peltonen; Paul Elliott; Lachlan J M Coin; George Davey Smith; Marjo-Riitta Jarvelin
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
PLoS genetics 2010;6(2):e1000856.
2010: Emma Lindh; Eleftheria Rosmaraki; Louise Berg; Hanna Brauner; Mikael C I Karlsson; Leena Peltonen; Petter Höglund; Ola Winqvist
AIRE deficiency leads to impaired iNKT cell development.
Journal of autoimmunity 2010;34(1):66-72.
2010: Anne Helle; Samuli Hirsjärvi; Leena Peltonen; Jouni Hirvonen; Susanne K Wiedmer; Tuulia Hyötyläinen
Novel, dynamic on-line analytical separation system for dissolution of drugs from poly(lactic acid) nanoparticles.
Journal of pharmaceutical and biomedical analysis 2010;51(1):125-30.
2010: Laura Kananen; Ida Surakka; sami pirkola; Jaana Suvisaari; Jouko Lönnqvist; Leena Peltonen; Samuli Ripatti; Iiris Hovatta
Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls.
PloS one 2010;5(5):e10826.
2010: Annu Näkki; Sanna T Kouhia; Janna Saarela; Arsi Harilainen; Kaj Tallroth; Tapio Videman; Michele C Battié; Jaakko Kaprio; Leena Peltonen; Urho M Kujala
Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.
BMC medical genetics 2010;11():50.
2009: John C Chambers; Weihua Zhang; Yun Li; Joban Sehmi; Mark N Wass; Delilah Zabaneh; Clive J Hoggart; Henry Bayele; Mark I McCarthy; Leena Peltonen; Nelson B Freimer; Kaila Surjit Srai; Patrick H Maxwell; Michael J E Sternberg; Aimo Ruokonen; Goncalo Abecasis; Marjo-Riitta Jarvelin; James Scott; Paul Elliott; Jaspal S Kooner
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.
Nature genetics 2009;41(11):1170-2.
2009: Kaisu Keskitalo; Ulla Broms; Markku Heliövaara; Samuli Ripatti; Ida Surakka; Markus Perola; Janne Pitkäniemi; Leena Peltonen; Arpo Aromaa; Jaakko Kaprio
Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15.
Human molecular genetics 2009;18(20):4007-12.
2009: Michele L Pergadia; Arpana Agrawal; Anu Loukola; Grant W Montgomery; Ulla Broms; Scott F Saccone; Jen C Wang; Alexandre A Todorov; Kauko Heikkilä; Dixie J Statham; Anjali K Henders; Megan J Campbell; John P Rice; Richard D Todd; Andrew C Heath; Alison Goate; Leena Peltonen; Jaakko Kaprio; Nicholas G Martin; Pamela A F Madden
Genetic linkage findings for DSM-IV nicotine withdrawal in two populations.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(7):950-9.
2009: Jussi Naukkarinen; Emma Nilsson; Heikki A Koistinen; Sanni Söderlund; Valeriya Lyssenko; Allan Vaag; Pernille Poulsen; Leif Groop; Marja-Riitta Taskinen; Leena Peltonen
Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias.
Circulation. Cardiovascular genetics 2009;2(5):522-9.
2009: Emma S Nyman; Anu Loukola; Teppo Varilo; Jesper Ekelund; Juha Veijola; Matti Joukamaa; Anja Taanila; Anneli Pouta; Jouko Miettunen; Nelson Freimer; Marjo-Riitta Järvelin; Leena Peltonen
Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(6):854-65.
2009: Tiina Paunio; Ritva Arajärvi; Joseph D Terwilliger; Tero Hiekkalinna; Perttu Haimi; Timo Partonen; Jouko Lönnqvist; Leena Peltonen; Teppo Varilo
Linkage analysis of schizophrenia controlling for population substructure.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(6):827-35.
2009: Hanna Valo; Leena Peltonen; Satu Vehviläinen; Milja Karjalainen; Risto Kostiainen; Timo Laaksonen; Jouni Hirvonen
Electrospray encapsulation of hydrophilic and hydrophobic drugs in poly(L-lactic acid) nanoparticles.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(15):1791-8.
2009: Jonna Tallila; Riitta Salonen; Nicolai Kohlschmidt; Leena Peltonen; Marjo Kestilä
Mutation spectrum of Meckel syndrome genes: one group of syndromes or several distinct groups?
Human mutation 2009;30(8):E813-30.
2009: Helena Kilpinen; Tero Ylisaukko-Oja; Karola Rehnström; Emilia Gaál; Joni A Turunen; Elli Kempas; Lennart von Wendt; Teppo Varilo; Leena Peltonen
Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland.
Human molecular genetics 2009;18(15):2912-21.
2009: Olli P H Pietiläinen; Tiina Paunio; Anu Loukola; Annamari Tuulio-Henriksson; Tuula Kieseppä; Paul Thompson; Arthur W Toga; Theo G M van Erp; Karri Silventoinen; Pia Soronen; William Hennah; Joni A Turunen; Juho Wedenoja; Outi M Palo; Kaisa Silander; Jouko Lönnqvist; Jaakko Kaprio; Tyrone D Cannon; Leena Peltonen
Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(5):683-92.
2009: Karola Rehnström; Tero Ylisaukko-Oja; Ilona Nummela; Pekka Ellonen; Elli Kempas; Raija Vanhala; Lennart von Wendt; Irma Järvelä; Leena Peltonen
Allelic variants in HTR3C show association with autism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(5):741-6.
2009: Liisa Tomppo; William Hennah; Päivi Lahermo; Anu Loukola; Annamari Tuulio-Henriksson; Jaana Suvisaari; Timo Partonen; Jesper Ekelund; Jouko Lönnqvist; Leena Peltonen
Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.
Biological psychiatry 2009;65(12):1055-62.
2009: Maël Lebreton; Anna Barnes; Jouko Miettunen; Leena Peltonen; Khanum Ridler; Juha Veijola; Päivikki Tanskanen; John Suckling; Marjo-Riitta Jarvelin; Peter B Jones; Matti Isohanni; Edward T Bullmore; Graham K Murray
The brain structural disposition to social interaction.
The European journal of neuroscience 2009;29(11):2247-52.
2009: Anu Kemppinen; Minna Suvela; Pentti J Tienari; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Ilkka Rautakorpi; Jan Hillert; Frida Lundmark; Annette Oturai; Lars Ryder; Hanne F Harbo; Elisabeth G Celius; Aarno Palotie; Mark J Daly; Leena Peltonen; Janna Saarela
MYO9B polymorphisms in multiple sclerosis.
European journal of human genetics : EJHG 2009;17(6):840-3.
2009: Brian P McEvoy; Grant W Montgomery; Allan F McRae; Samuli Ripatti; Markus Perola; Tim D Spector; Lynn Cherkas; Kourosh R Ahmadi; Dorret Boomsma; Gonneke Willemsen; Jouke-Jan Hottenga; Nancy L Pedersen; Patrik K E Magnusson; Kirsten Ohm Kyvik; Kaare Christensen; Jaakko Kaprio; Kauko Heikkilä; Aarno Palotie; Elisabeth Widen; Juha Muilu; Ann-Christine Syvänen; Ulrika Liljedahl; Orla Hardiman; Simon Cronin; Leena Peltonen; Nicholas G Martin; Peter M Visscher
Geographical structure and differential natural selection among North European populations.
Genome research 2009;19(5):804-14.
2009: Suvi P Kallio; Eveliina Jakkula; Shaun Purcell; Minna Suvela; Keijo Koivisto; Pentti J Tienari; Irina Elovaara; Tuula Pirttilä; Mauri Reunanen; Denis Bronnikov; Markku Viander; Seppo Meri; Jan Hillert; Frida Lundmark; Hanne F Harbo; Aslaug R Lorentzen; Philip L De Jager; Mark J Daly; David A Hafler; Aarno Palotie; Leena Peltonen; Janna Saarela
Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.
Human molecular genetics 2009;18(9):1670-83.
2009: A Marjamaa; Christopher Newton-Cheh; K Porthan; Antti Reunanen; Päivi Lahermo; Heikki Väänänen; Antti Jula; H Karanko; H Swan; Lauri Toivonen; Markku S Nieminen; Matti Viitasalo; Leena Peltonen; L Oikarinen; Aarno Palotie; Kimmo Kontula; Veikko Salomaa
Common candidate gene variants are associated with QT interval duration in the general population.
Journal of internal medicine 2009;265(4):448-58.
2009: Juha Karvanen; Kaisa Silander; Frank Kee; Laurence Tiret; Veikko Salomaa; Kari Kuulasmaa; Per-Gunnar Wiklund; Jarmo Virtamo; Olli Saarela; Claire Perret; Markus Perola; Leena Peltonen; Francois Cambien; Jeanette Erdmann; Nilesh J Samani; Heribert Schunkert; Alun Evans
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.
Genetic epidemiology 2009;33(3):237-46.
2009: Ulla Sovio; Amanda J Bennett; Iona Y Millwood; John Molitor; Paul F O'Reilly; Nicholas J Timpson; Marika Kaakinen; Jaana Laitinen; Jari Haukka; Demetris Pillas; Ioanna Tzoulaki; Jassy Molitor; Clive J Hoggart; Lachlan J M Coin; John Whittaker; Anneli Pouta; Anna-Liisa Hartikainen; Nelson B Freimer; Elisabeth Widen; Leena Peltonen; Paul Elliott; Mark I McCarthy; Marjo-Riitta Jarvelin
Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.
PLoS genetics 2009;5(3):e1000409.
2009: Paula Lehto; Jaakko Aaltonen; Mikko Tenho; Jukka Rantanen; Jouni Hirvonen; Veli Pekka Tanninen; Leena Peltonen
Solvent-mediated solid phase transformations of carbamazepine: Effects of simulated intestinal fluid and fasted state simulated intestinal fluid.
Journal of pharmaceutical sciences 2009;98(3):985-96.
2009: Liisa Tomppo; William Hennah; Jouko Miettunen; Marjo-Riitta Järvelin; Juha Veijola; Samuli Ripatti; Päivi Lahermo; Dirk Lichtermann; Leena Peltonen; Jesper Ekelund
Association of variants in DISC1 with psychosis-related traits in a large population cohort.
Archives of general psychiatry 2009;66(2):134-41.
2009: Sampo Sammalisto; Tero Hiekkalinna; Karen Schwander; Sharon L R Kardia; Alan B Weder; Beatriz L Rodriguez; Alessandro Doria; Jennifer A Kelly; Gail R Bruner; John B Harley; Susan Redline; Emma K Larkin; Sanjay R Patel; Amy J H Ewan; James L Weber; Markus Perola; Leena Peltonen
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects.
European journal of human genetics : EJHG 2009;17(2):258-66.
2009: Anna-Maija Sulonen; Suvi P Kallio; Pekka Ellonen; Minna Suvela; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Pentti J Tienari; Aarno Palotie; Leena Peltonen; Janna Saarela
No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.
Journal of neuroimmunology 2009;206(1-2):86-90.
2009: Kaisa Silander; Hua Tang; Sean Myles; Eveliina Jakkula; Nicholas J Timpson; Luigi Cavalli-Sforza; Leena Peltonen
Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.
Genome medicine 2009;1(5):51.
2009: Samuli Hirsjärvi; Leena Peltonen; Jouni Hirvonen
Effect of sugars, surfactant, and tangential flow filtration on the freeze-drying of poly(lactic acid) nanoparticles.
AAPS PharmSciTech 2009;10(2):488-94.
2009: Annukka Marjamaa; Veikko Salomaa; Christopher Newton-Cheh; Kimmo Porthan; Antti Reunanen; Hannu Karanko; Antti Jula; Päivi Lahermo; Heikki Väänänen; Lauri Toivonen; Heikki Swan; Matti Viitasalo; Markku S Nieminen; Leena Peltonen; Lasse Oikarinen; Aarno Palotie; Kimmo Kontula
High prevalence of four long QT syndrome founder mutations in the Finnish population.
Annals of medicine 2009;41(3):234-40.
2009: Beben Benyamin; Allan F McRae; Gu Zhu; Scott Gordon; Anjali K Henders; Aarno Palotie; Leena Peltonen; Nicholas G Martin; Grant W Montgomery; John B Whitfield; Peter M Visscher
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
American journal of human genetics 2009;84(1):60-5.
2009: Chiara Sabatti; Susan K Service; Anna-Liisa Hartikainen; Anneli Pouta; Samuli Ripatti; Jae Brodsky; Chris G Jones; Noah A Zaitlen; Teppo Varilo; Marika Kaakinen; Ulla Sovio; Aimo Ruokonen; Jaana Laitinen; Eveliina Jakkula; Lachlan Coin; Clive Hoggart; ANDREW COLLINS; Hannu Turunen; Stacey Gabriel; Paul Elliot; Mark I McCarthy; Mark J Daly; Marjo-Riitta Järvelin; Nelson B Freimer; Leena Peltonen
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Nature genetics 2009;41(1):35-46.
2008: Ake T Lu; Matthew N Ogdie; Marjo-Ritta Järvelin; Irma K Moilanen; Sandra K Loo; James T McCracken; James J McGough; May H Yang; Leena Peltonen; Stanley F Nelson; Rita M Cantor; Susan L Smalley
Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(8):1488-94.
2008: Emma Lindh; Sara M Lind; Evelina Lindmark; Signe Hässler; Jaakko Perheentupa; Leena Peltonen; Ola Winqvist; Mikael C I Karlsson
AIRE regulates T-cell-independent B-cell responses through BAFF.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18466-71.
2008: Paula Lehto; Jaakko Aaltonen; Pentti Niemelä; Jukka Rantanen; Jouni Hirvonen; Veli Pekka Tanninen; Leena Peltonen
Simultaneous measurement of liquid-phase and solid-phase transformation kinetics in rotating disc and channel flow cell dissolution devices.
International journal of pharmaceutics 2008;363(1-2):66-72.
2008: Jonas Donner; sami pirkola; Kaisa Silander; Laura Kananen; Joseph D Terwilliger; Jouko Lönnqvist; Leena Peltonen; Iiris Hovatta
An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.
Biological psychiatry 2008;64(8):672-80.
2008: Nora Pöntynen; Mari Strengell; Niko Sillanpää; Juha Saharinen; Ismo Ulmanen; Ilkka Julkunen; Leena Peltonen
Critical immunological pathways are downregulated in APECED patient dendritic cells.
Journal of molecular medicine (Berlin, Germany) 2008;86(10):1139-52.
2008: Christina G S Palmer; Erin Mallery; Joni A Turunen; Hsyue-Jen Hsieh; Leena Peltonen; Jouko Lonnqvist; J Arthur Woodward; Janet S Sinsheimer
Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex.
Schizophrenia research 2008;104(1-3):135-45.
2008: Kaisa Valli-Jaakola; Elina Suviolahti; Camilla Schalin-Jäntti; Samuli Ripatti; Kaisa Silander; Laura Oksanen; Veikko Salomaa; Leena Peltonen; Kimmo Kontula
Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns.
Obesity (Silver Spring, Md.) 2008;16(9):2113-9.
2008: Pia Soronen; Kaisa Silander; Mervi Antila; Outi M Palo; Annamari Tuulio-Henriksson; Tuula Kieseppä; Pekka Ellonen; Juho Wedenoja; Joni A Turunen; Olli P H Pietiläinen; William Hennah; Jouko Lönnqvist; Leena Peltonen; Timo Partonen; Tiina Paunio
Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.
Biological psychiatry 2008;64(5):438-42.
2008: Per E Lundmark; Ulrika Liljedahl; Dorret I Boomsma; Heikki Mannila; Nicholas G Martin; Aarno Palotie; Leena Peltonen; Markus Perola; Tim D Spector; Ann-Christine Syvänen
Evaluation of HapMap data in six populations of European descent.
European journal of human genetics : EJHG 2008;16(9):1142-50.
2008: Patrik K E Magnusson; Marcus Boman; Ulf de Faire; Markus Perola; Leena Peltonen; Nancy L Pedersen
Genome-wide search for QTLs for apolipoprotein A-I level in elderly Swedish DZ twins: evidence of female-specific locus on 15q11-13.
European journal of human genetics : EJHG 2008;16(9):1103-10.
2008: Linda Mustelin; Kirsi H Pietiläinen; Aila Rissanen; Anssi R Sovijärvi; Päivi Piirilä; Jussi Naukkarinen; Leena Peltonen; Jaakko Kaprio; Hannele Yki-Järvinen
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E148-54.
2008: J Wedenoja; Anu Loukola; Annamari Tuulio-Henriksson; Tiina Paunio; Jesper Ekelund; Kaisa Silander; Teppo Varilo; K Heikkilä; Jaana Suvisaari; Timo Partonen; Jouko Lönnqvist; Leena Peltonen
Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families.
Molecular psychiatry 2008;13(7):673-84.
2008: Jonna Tallila; Eveliina Jakkula; Leena Peltonen; Riitta Salonen; Marjo Kestilä
Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle.
American journal of human genetics 2008;82(6):1361-7.
2008: Signe Hässler; Leena Peltonen; Stellan Sandler; Ola Winqvist
Aire deficiency causes increased susceptibility to streptozotocin-induced murine type 1 diabetes.
Scandinavian journal of immunology 2008;67(6):569-80.
2008: Anu Loukola; U Broms; H Maunu; Elisabeth Widén; K Heikkilä; M Siivola; A Salo; M L Pergadia; E Nyman; Sampo Sammalisto; Markus Perola; A Agrawal; A C Heath; Nicholas G Martin; P A F Madden; Leena Peltonen; Jaakko Kaprio
Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background.
The pharmacogenomics journal 2008;8(3):209-19.
2008: Verneri Anttila; Dale R Nyholt; Mikko Kallela; Ville Artto; Salli Vepsäläinen; Eveliina Jakkula; Annika Wennerström; Päivi Tikka-Kleemola; Mari A Kaunisto; Eija Hämäläinen; Elisabeth Widén; Joseph D Terwilliger; Kathleen Ries Merikangas; Grant W Montgomery; Nicholas G Martin; Mark J Daly; Jaakko Kaprio; Leena Peltonen; Markus Färkkilä; Maija Wessman; Aarno Palotie
Consistently replicating locus linked to migraine on 10q22-q23.
American journal of human genetics 2008;82(5):1051-63.
2008: Kati Kristiansson; Erkki Ilveskoski; Terho Lehtimäki; Leena Peltonen; Markus Perola; Pekka J Karhunen
Association analysis of allelic variants of USF1 in coronary atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):983-9.
2008: Beben Benyamin; Markus Perola; Belinda K Cornes; Pamela Af Madden; Aarno Palotie; Dale R Nyholt; Grant W Montgomery; Leena Peltonen; Nicholas G Martin; Peter M Visscher
Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs.
European journal of human genetics : EJHG 2008;16(4):516-24.
2008: Kirsi H Pietiläinen; Jussi Naukkarinen; Aila Rissanen; Juha Saharinen; Pekka Ellonen; Heli Keränen; Anu Suomalainen; Alexandra Götz; Tapani Suortti; Hannele Yki-Järvinen; Matej Oresic; Jaakko Kaprio; Leena Peltonen
Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity.
PLoS medicine 2008;5(3):e51.
2008: Mohammad Alimohammadi; Peyman Björklund; Asa Hallgren; Nora Pöntynen; Gabor Szinnai; Noriko Shikama; Marcel P Keller; Olov Ekwall; Sarah A Kinkel; Eystein S Husebye; Jan Gustafsson; Fredrik Rorsman; Leena Peltonen; Corrado Betterle; Jaakko Perheentupa; Göran Akerström; Gunnar Westin; Hamish Scott; Georg A Holländer; Kämpe Olle
Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.
The New England journal of medicine 2008;358(10):1018-28.
2008: Kirsi Auro; K Kristiansson; Björn Zethelius; C Berne; Lars Lannfelt; Marja-Riitta Taskinen; Matti Jauhiainen; Markus Perola; Leena Peltonen; Ann-Christine Syvänen
USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.
Diabetologia 2008;51(3):464-72.
2008: Samuli Hirsjärvi; Leena Peltonen; Jouni Hirvonen
Surface pressure measurements in particle interaction and stability studies of poly(lactic acid) nanoparticles.
International journal of pharmaceutics 2008;348(1-2):153-60.
2008: Heidi O Nousiainen; Marjo Kestilä; Niklas Pakkasjärvi; Heli Honkala; Satu Kuure; Jonna Tallila; Katri Vuopala; Jaakko Ignatius; Riitta Herva; Leena Peltonen
Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease.
Nature genetics 2008;40(2):155-7.
2008: H Kilpinen; Tero Ylisaukko-Oja; William Hennah; Outi M Palo; Teppo Varilo; Raija Vanhala; Taina Nieminen-von Wendt; Lennart von Wendt; Tiina Paunio; Leena Peltonen
Association of DISC1 with autism and Asperger syndrome.
Molecular psychiatry 2008;13(2):187-96.
2008: Anne Helle; Samuli Hirsjärvi; Leena Peltonen; Jouni Hirvonen; Susanne K Wiedmer
Quantitative determination of drug encapsulation in poly(lactic acid) nanoparticles by capillary electrophoresis.
Journal of chromatography. A 2008;1178(1-2):248-55.
2008: Karola Rehnström; Tero Ylisaukko-Oja; Raija Vanhala; Lennart von Wendt; Leena Peltonen; Iiris Hovatta
No association between common variants in glyoxalase 1 and autism spectrum disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(1):124-7.
2008: Kaisa Silander; Mervi Alanne; Kati Kristiansson; Olli Saarela; Samuli Ripatti; Kirsi Auro; Juha Karvanen; Sangita Kulathinal; Matti Niemelä; Pekka Ellonen; Erkki Vartiainen; Pekka Jousilahti; Janna Saarela; Kari Kuulasmaa; Alun Evans; Markus Perola; Veikko Salomaa; Leena Peltonen
Gender differences in genetic risk profiles for cardiovascular disease.
PloS one 2008;3(10):e3615.
2008: Kati Kristiansson; Jussi Naukkarinen; Leena Peltonen
Isolated populations and complex disease gene identification.
Genome biology 2008;9(8):109.
2008: Carina von Schantz; Juha Saharinen; Outi Kopra; Jonathan D Cooper; Massimiliano Gentile; Iiris Hovatta; Leena Peltonen; Anu Jalanko
Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases.
BMC genomics 2008;9():146.
2008: Nabil Sabri Enattah; Tine G K Jensen; Mette Nielsen; Rikke Lewinski; Mikko Kuokkanen; Heli Rasinpera; Hatem El-Shanti; Jeong Kee Seo; Michael Alifrangis; Insaf F Khalil; Abdrazak Natah; Ahmed Ali; Sirajedin Natah; David Comas; S Qasim Mehdi; Leif Groop; Else Marie Vestergaard; Faiqa Imtiaz; Mohamed S Rashed; Brian Meyer; Jesper T Troelsen; Leena Peltonen
Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture.
American journal of human genetics 2008;82(1):57-72.
2007: Emma S Nyman; Matthew N Ogdie; Anu Loukola; Teppo Varilo; Anja Taanila; Tuula Hurtig; Irma Moilanen; Sandra K Loo; James J McGough; Marjo-Riitta Järvelin; Susan L Smalley; Stanley F Nelson; Leena Peltonen
ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2.
Journal of the American Academy of Child and Adolescent Psychiatry 2007;46(12):1614-21.
2007: Susan L Smalley; James J McGough; Irma Moilanen; Sandra K Loo; Anja Taanila; Hanna Ebeling; Tuula Hurtig; Marika Kaakinen; Lorie A Humphrey; James T McCracken; Teppo Varilo; May H Yang; Stanley F Nelson; Leena Peltonen; Marjo-Riitta Järvelin
Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish population.
Journal of the American Academy of Child and Adolescent Psychiatry 2007;46(12):1575-83.
2007: Timo Laaksonen; Hélder A. Santos; Henna Vihola; Jarno Salonen; Joakim Riikonen; Teemu Heikkilä; Leena Peltonen; Narendra Kumar; Dmitry Yu Murzin; Vesa-Pekka Lehto; Jouni Hirvonen
Failure of MTT as a toxicity testing agent for mesoporous silicon microparticles.
Chemical research in toxicology 2007;20(12):1913-8.
2007: Weidong Li; Yu Zhou; J David Jentsch; Robert A M Brown; Xiaoli Tian; Dan Ehninger; William Hennah; Leena Peltonen; Jouko Lönnqvist; Matti O Huttunen; Jaakko Kaprio; Joshua T Trachtenberg; Alcino J Silva; Tyrone D Cannon
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18280-5.
2007: Mervi Alanne; Kati Kristiansson; Kirsi Auro; Kaisa Silander; Kari Kuulasmaa; Leena Peltonen; Veikko Salomaa; Markus Perola
Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts.
Human genetics 2007;122(3-4):355-65.
2007: Outi M Palo; Mervi Antila; Kaisa Silander; William Hennah; Helena Kilpinen; Pia Soronen; Annamari Tuulio-Henriksson; Tuula Kieseppä; Timo Partonen; Jouko Lönnqvist; Leena Peltonen; Tiina Paunio
Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments.
Human molecular genetics 2007;16(20):2517-28.
2007: Nabil Sabri Enattah; Aimee Trudeau; Ville Pimenoff; Luigi Maiuri; Salvatore Auricchio; Luigi Greco; Mauro Rossi; Michael Lentze; J K Seo; Soheila Rahgozar; Insaf F Khalil; Michael Alifrangis; Sirajedin Natah; Leif Groop; Nael Shaat; Andrew Kozlov; Galina Verschubskaya; David Comas; Kazima B Bulayeva; S Qasim Mehdi; Joseph D Terwilliger; Timo Sahi; Erkki Savilahti; Markus Perola; Antti Sajantila; Irma Järvelä; Leena Peltonen
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
American journal of human genetics 2007;81(3):615-25.
2007: Anna Kiialainen; Ville Veckman; Juha Saharinen; Juha Paloneva; Massimiliano Gentile; Panu Hakola; Dimitri Hemelsoet; Basil Ridha; Outi Kopra; Ilkka Julkunen; Leena Peltonen
Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response.
Journal of molecular medicine (Berlin, Germany) 2007;85(9):971-83.
2007: Antti Knaapila; Hely Tuorila; Karri Silventoinen; Kaisu Keskitalo; Mikko Kallela; Maija Wessman; Leena Peltonen; Lynn F Cherkas; Tim D Spector; Markus Perola
Food neophobia shows heritable variation in humans.
Physiology & behavior 2007;91(5):573-8.
2007: Nabil Sabri Enattah; Mikko Kuokkanen; Carol Forsblom; Sirajedin Natah; Aino Oksanen; Irma Jarvela; Leena Peltonen; Erkki Savilahti
Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age.
World journal of gastroenterology : WJG 2007;13(25):3508-12.
2007: Kirsi Auro; Mervi Alanne; Kati Kristiansson; Kaisa Silander; Kari Kuulasmaa; Veikko Salomaa; Leena Peltonen; Markus Perola
Combined effects of thrombosis pathway gene variants predict cardiovascular events.
PLoS genetics 2007;3(7):e120.
2007: Kaisu Keskitalo; Antti Knaapila; Mikko Kallela; Aarno Palotie; Maija Wessman; Sampo Sammalisto; Leena Peltonen; Hely Tuorila; Markus Perola
Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16.
The American journal of clinical nutrition 2007;86(1):55-63.
2007: Juha Muilu; Leena Peltonen; Jan-Eric Litton
The federated database--a basis for biobank-based post-genome studies, integrating phenome and genome data from 600,000 twin pairs in Europe.
European journal of human genetics : EJHG 2007;15(7):718-23.
2007: Markus Perola; Sampo Sammalisto; Tero Hiekkalinna; Nick G Martin; Peter M Visscher; Grant W Montgomery; Beben Benyamin; Jennifer R Harris; Dorret I Boomsma; Gonneke Willemsen; Jouke-Jan Hottenga; Kaare Christensen; Kirsten Ohm Kyvik; Thorkild I A Sørensen; Nancy L Pedersen; Patrik K E Magnusson; Tim D Spector; Elisabeth Widen; Karri Silventoinen; Jaakko Kaprio; Aarno Palotie; Leena Peltonen
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.
PLoS genetics 2007;3(6):e97.
2007: Aino Soro-Paavonen; Jussi Naukkarinen; Miriam Lee-Rueckert; Hiroshi Watanabe; Elina Rantala; Sanni Soderlund; Anne Hiukka; Petri T Kovanen; Matti Jauhiainen; Leena Peltonen; Marja-Riitta Taskinen
Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.
Journal of lipid research 2007;48(6):1409-16.
2007: Antti Knaapila; Kaisu Keskitalo; Mikko Kallela; Maija Wessman; Sampo Sammalisto; Tero Hiekkalinna; Aarno Palotie; Leena Peltonen; Hely Tuorila; Markus Perola
Genetic component of identification, intensity and pleasantness of odours: a Finnish family study.
European journal of human genetics : EJHG 2007;15(5):596-602.
2007: Joni A Turunen; Juho O Peltonen; Olli P H Pietiläinen; William Hennah; Anu Loukola; Tiina Paunio; Kaisa Silander; Jesper Ekelund; Teppo Varilo; Timo Partonen; Jouko Lönnqvist; Leena Peltonen
The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland.
Schizophrenia research 2007;91(1-3):27-36.
2007: William Hennah; Liisa Tomppo; Tero Hiekkalinna; Outi M Palo; Helena Kilpinen; Jesper Ekelund; Annamari Tuulio-Henriksson; Kaisa Silander; Timo Partonen; Tiina Paunio; Joseph D Terwilliger; Jouko Lönnqvist; Leena Peltonen
Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1.
Human molecular genetics 2007;16(5):453-62.
2007: Niklas Pakkasjärvi; Laura Kerosuo; Heidi Nousiainen; Massimiliano Gentile; Juha Saharinen; Satu Suhonen; Hannu Sariola; Leena Peltonen; Marjo Kestilä; Kirmo Wartiovaara
Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expression.
Developmental neurobiology 2007;67(3):270-84.
2007: Ker-Chau Li; Aarno Palotie; Shinsheng Yuan; Denis Bronnikov; Daniel Chen; Xuelian Wei; Oi-Wa Choi; Janna Saarela; Leena Peltonen
Finding disease candidate genes by liquid association.
Genome biology 2007;8(10):R205.
2007: Timo Partonen; Jens Treutlein; Asude Alpman; Josef Frank; Carolina Johansson; Martin Depner; Liviu Aron; Marcella Rietschel; Stefan Wellek; Pia Soronen; Tiina Paunio; Andreas Koch; Ping Chen; Mark Lathrop; Rolf Adolfsson; Maj-Liz Persson; Siegfried Kasper; Martin Schalling; Leena Peltonen; Gunter Schumann
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.
Annals of medicine 2007;39(3):229-38.
2006: Johan Brännström; Signe Hässler; Leena Peltonen; Björn Herrmann; Ola Winqvist
Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens.
Clinical immunology (Orlando, Fla.) 2006;121(3):265-73.
2006: Jaakko Aaltonen; Paula Heinänen; Leena Peltonen; Hanna Kortejärvi; Veli Pekka Tanninen; Leena Christiansen; Jouni Hirvonen; Jouko Yliruusi; Jukka Rantanen
In situ measurement of solvent-mediated phase transformations during dissolution testing.
Journal of pharmaceutical sciences 2006;95(12):2730-7.
2006: Anu Jalanko; Jaana Tyynelä; Leena Peltonen
From genes to systems: new global strategies for the characterization of NCL biology.
Biochimica et biophysica acta 2006;1762(10):934-44.
2006: Christina G S Palmer; Hsyue-Jen Hsieh; Elaine F Reed; Jouko Lonnqvist; Leena Peltonen; J Arthur Woodward; Janet S Sinsheimer
HLA-B maternal-fetal genotype matching increases risk of schizophrenia.
American journal of human genetics 2006;79(4):710-5.
2006: Signe Hässler; Chris Ramsey; Mikael C Karlsson; Disa Larsson; Björn Herrmann; Björn Rozell; Magnus Backheden; Leena Peltonen; Kämpe Olle; Ola Winqvist
Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma.
Blood 2006;108(6):1941-8.
2006: Samuli Hirsjärvi; Leena Peltonen; Laura Kainu; Jouni Hirvonen
Freeze-drying of low molecular weight poly(L-lactic acid) nanoparticles: effect of cryo- and lyoprotectants.
Journal of nanoscience and nanotechnology 2006;6(9-10):3110-7.
2006: Niklas Pakkasjärvi; Annukka Ritvanen; Riitta Herva; Leena Peltonen; Marjo Kestilä; Jaakko Ignatius
Lethal congenital contracture syndrome (LCCS) and other lethal arthrogryposes in Finland--an epidemiological study.
American journal of medical genetics. Part A 2006;140A(17):1834-9.
2006: Nora Pöntynen; Aaro Miettinen; T Petteri Arstila; Kämpe Olle; Mohammad Alimohammadi; Outi Vaarala; Leena Peltonen; Ismo Ulmanen
Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients.
Journal of autoimmunity 2006;27(2):96-104.
2006: Verneri Anttila; Mikko Kallela; Greg Oswell; Mari A Kaunisto; Dale R Nyholt; E Hamalainen; Hannele Havanka; Matti Ilmavirta; Joseph D Terwilliger; Eric Sobel; Leena Peltonen; Jaakko Kaprio; M Farkkila; Maija Wessman; Aarno Palotie
Trait components provide tools to dissect the genetic susceptibility of migraine.
American journal of human genetics 2006;79(1):85-99.
2006: Sonia L Minassian; Christina G S Palmer; Joni A Turunen; Tiina Paunio; Jouko Lönnqvist; Leena Peltonen; J Arthur Woodward; Janet S Sinsheimer
Incorporating serotypes into family based association studies using the MFG test.
Annals of human genetics 2006;70(Pt 4):541-53.
2006: William Hennah; Pippa Thomson; Leena Peltonen; David Porteous
Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness.
Schizophrenia bulletin 2006;32(3):409-16.
2006: Jussi Naukkarinen; Christian Ehnholm; Leena Peltonen
Genetics of familial combined hyperlipidemia.
Current opinion in lipidology 2006;17(3):285-90.
2006: Joni A Turunen; Maija Wessman; Carol Forsblom; Riika Kilpikari; Maija Parkkonen; Nora Pöntynen; Tanja Ilmarinen; Ismo Ulmanen; Leena Peltonen; Per-Henrik Groop
Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients.
Immunogenetics 2006;58(5-6):331-8.
2006: Kati Komulainen; Mervi Alanne; Kirsi Auro; Riika Kilpikari; Päivi Pajukanta; Janna Saarela; Pekka Ellonen; Kaisa Salminen; Sangita Kulathinal; Kari Kuulasmaa; Kaisa Silander; Veikko Salomaa; Markus Perola; Leena Peltonen
Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies.
PLoS genetics 2006;2(5):e69.
2006: Susan K Service; Joseph DeYoung; Maria Karayiorgou; J Louw Roos; Herman Pretorious; Gabriel Bedoya; Jorge Ospina; Andres Ruiz-Linares; antonio macedo; Joana Almeida Palha; Peter Heutink; Yurii Aulchenko; Ben Oostra; C.M. Duijn; Marjo-Riitta Jarvelin; Teppo Varilo; Lynette Peddle; Proton Rahman; Giovanna Piras; Maria Monne; Sarah Murray; Luana Galver; Leena Peltonen; Chiara Sabatti; ANDREW COLLINS; Nelson B Freimer
Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies.
Nature genetics 2006;38(5):556-60.
2006: Leena Peltonen; Markus Perola; Jussi Naukkarinen; Aarno Palotie
Lessons from studying monogenic disease for common disease.
Human molecular genetics 2006;15 Spec No 1():R67-74.
2006: Samuli Hirsjärvi; Leena Peltonen; Jouni Hirvonen
Layer-by-layer polyelectrolyte coating of low molecular weight poly(lactic acid) nanoparticles.
Colloids and surfaces. B, Biointerfaces 2006;49(1):93-9.
2006: Kirsi Auro; Kati Komulainen; Mervi Alanne; Kaisa Silander; Leena Peltonen; Markus Perola; Veikko Salomaa
Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):942-7.
2006: Janna Saarela; Suvi P Kallio; Daniel Chen; Alexandre Montpetit; Anne Jokiaho; Eva Choi; Rosanna Asselta; Denis Bronnikov; Matthew R Lincoln; A Dessa Sadovnick; Pentti J Tienari; Keijo Koivisto; Aarno Palotie; George C Ebers; Thomas J Hudson; Leena Peltonen
PRKCA and multiple sclerosis: association in two independent populations.
PLoS genetics 2006;2(3):e42.
2006: Karola Rehnström; Tero Ylisaukko-Oja; Taina Nieminen-von Wendt; Susan Sarenius; T Källman; Elli Kempas; Lennart von Wendt; Leena Peltonen; Irma Järvelä
Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome.
Journal of medical genetics 2006;43(2):e6.
2006: Chris Ramsey; Signe Hässler; Per Marits; Kämpe Olle; Charles D Surh; Leena Peltonen; Ola Winqvist
Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator.
European journal of immunology 2006;36(2):305-17.
2006: Mira Kyttälä; Jonna Tallila; Riitta Salonen; Outi Kopra; Nicolai Kohlschmidt; Paulina Paavola-Sakki; Leena Peltonen; Marjo Kestilä
MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome.
Nature genetics 2006;38(2):155-7.
2006: Mikko Kuokkanen; Jorma Kokkonen; Nabil Sabri Enattah; Tero Ylisaukko-Oja; Hanna Komu; Teppo Varilo; Leena Peltonen; Erkki Savilahti; Irma Jarvela
Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency.
American journal of human genetics 2006;78(2):339-44.
2006: Elina Suviolahti; Karen Reue; Rita M Cantor; Jack Phan; Massimiliano Gentile; Jussi Naukkarinen; Aino Soro-Paavonen; Laura J Oksanen; Jaakko Kaprio; Aila Rissanen; Veikko Salomaa; Kimmo Kontula; Marja-Riitta Taskinen; Päivi Pajukanta; Leena Peltonen
Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism.
Human molecular genetics 2006;15(3):377-86.
2006: Kaisa Valli-Jaakola; Jorma J Palvimo; Marita Lipsanen-Nyman; Veikko Salomaa; Leena Peltonen; Kimmo Kontula; Camilla Schalin-Jäntti
A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity.
Hormone research 2006;66(2):61-9.
2006: Tero Ylisaukko-Oja; Maricela Alarcón; Rita M Cantor; Mari Auranen; Raija Vanhala; Elli Kempas; Lennart von Wendt; Irma Järvelä; Daniel Geschwind; Leena Peltonen
Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families.
Annals of neurology 2006;59(1):145-55.
2006: Thomas A Trikalinos; A Karvouni; Elias Zintzaras; Tero Ylisaukko-Oja; Leena Peltonen; Irma Järvelä; John Ioannidis
A heterogeneity-based genome search meta-analysis for autism-spectrum disorders.
Molecular psychiatry 2006;11(1):29-36.
2005: H M F Riise Stensland; Janna Saarela; Denis O Bronnikov; Maija Parkkonen; Anne Jokiaho; Aarno Palotie; Pentti J Tienari; Marja-Liisa Sumelahti; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Eric Sobel; Leena Peltonen
Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.
Journal of neuroimmunology 2005;170(1-2):122-33.
2005: Ismo Ulmanen; Maria Halonen; Tanja Ilmarinen; Leena Peltonen
Monogenic autoimmune diseases - lessons of self-tolerance.
Current opinion in immunology 2005;17(6):609-15.
2005: Niklas Pakkasjärvi; Massimiliano Gentile; Juha Saharinen; Jarno Honkanen; Riitta Herva; Leena Peltonen; Marjo Kestilä
Indicative oligodendrocyte dysfunction in spinal cords of human fetuses suffering from a lethal motoneuron disease.
Journal of neurobiology 2005;65(3):269-81.
2005: William Hennah; Annamari Tuulio-Henriksson; Tiina Paunio; Jesper Ekelund; Teppo Varilo; Timo Partonen; Tyrone D Cannon; Jouko Lönnqvist; Leena Peltonen
A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia.
Molecular psychiatry 2005;10(12):1097-103.
2005: Tero Ylisaukko-Oja; Karola Rehnström; Mari Auranen; Raija Vanhala; Reija Alen; Elli Kempas; Pekka Ellonen; Joni A Turunen; Ismo Makkonen; Raili Riikonen; Taina Nieminen-von Wendt; Lennart von Wendt; Leena Peltonen; Irma Järvelä
Analysis of four neuroligin genes as candidates for autism.
European journal of human genetics : EJHG 2005;13(12):1285-92.
2005: Sampo Sammalisto; Tero Hiekkalinna; Elina Suviolahti; K Sood; A Metzidis; Päivi Pajukanta; Heidi E Lilja; Aino Soro-Paavonen; Marja-Riitta Taskinen; Tiinamaija Tuomi; Peter Almgren; Marju Orho-Melander; L Groop; Leena Peltonen; Markus Perola
A male-specific quantitative trait locus on 1p21 controlling human stature.
Journal of medical genetics 2005;42(12):932-9.
2005: Tyrone D Cannon; William Hennah; Theo G M van Erp; Paul M Thompson; Jouko Lonnqvist; Matti O Huttunen; Timothy L Gasperoni; Annamari Tuulio-Henriksson; Tiia Pirkola; Arthur W Toga; Jaakko Kaprio; John C Mazziotta; Leena Peltonen
Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.
Archives of general psychiatry 2005;62(11):1205-13.
2005: Kaisu Nikali; Anu Suomalainen; Juha Saharinen; Mikko Kuokkanen; Johannes N Spelbrink; Tuula Lönnqvist; Leena Peltonen
Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky.
Human molecular genetics 2005;14(20):2981-90.
2005: Matthew R Lincoln; Alexandre Montpetit; zameel cader; Janna Saarela; David A Dyment; Milvi Tiislar; Vincent Ferretti; Pentti J Tienari; A Dessa Sadovnick; Leena Peltonen; George C Ebers; Thomas J Hudson
A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.
Nature genetics 2005;37(10):1108-12.
2005: Jussi Naukkarinen; Massimiliano Gentile; Aino Soro-Paavonen; Janna Saarela; Heikki A Koistinen; Päivi Pajukanta; Marja-Riitta Taskinen; Leena Peltonen
USF1 and dyslipidemias: converging evidence for a functional intronic variant.
Human molecular genetics 2005;14(17):2595-605.
2005: Kaisa Silander; Kati Komulainen; Pekka Ellonen; Minttu Jussila; Mervi Alanne; Minna Levander; Päivi Tainola; Kari Kuulasmaa; Veikko Salomaa; Markus Perola; Leena Peltonen; Janna Saarela
Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(4):368-75.
2005: Jari Lahti; Katri Räikkönen; Jesper Ekelund; Leena Peltonen; Olli T Raitakari; Liisa Keltikangas-Järvinen
Novelty seeking: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years.
Psychiatric genetics 2005;15(2):133-9.
2005: Lisa Mee; Heli Honkala; Outi Kopra; Jouni Vesa; Saara Finnilä; Ilona Visapää; Tzu-Kang Sang; George R Jackson; Riitta Salonen; Marjo Kestilä; Leena Peltonen
Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1.
Human molecular genetics 2005;14(11):1475-88.
2005: S Hyvönen; Leena Peltonen; Milja Karjalainen; Jouni Hirvonen
Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly(L-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate.
International journal of pharmaceutics 2005;295(1-2):269-81.
2005: Hans H Klünemann; B H Ridha; L Magy; J R Wherrett; Dimitri Hemelsoet; R W Keen; Jan L De Bleecker; Martin N Rossor; Jörg Marienhagen; Helmfried E Klein; Leena Peltonen; J Paloneva
The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.
Neurology 2005;64(9):1502-7.
2005: Anna Kiialainen; Karine Hovanes; Juha Paloneva; Outi Kopra; Leena Peltonen
Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS.
Neurobiology of disease 2005;18(2):314-22.
2005: Tero Hiekkalinna; Joseph D Terwilliger; Sampo Sammalisto; Leena Peltonen; Markus Perola
AUTOGSCAN: powerful tools for automated genome-wide linkage and linkage disequilibrium analysis.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(1):16-21.
2005: Anu Jalanko; Jouni Vesa; Tuula Manninen; Carina von Schantz; Helena Minye; Anna-Liisa Fabritius; Tarja Salonen; Juhani Rapola; Massimiliano Gentile; Outi Kopra; Leena Peltonen
Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons.
Neurobiology of disease 2005;18(1):226-41.
2005: Alun Evans; Veikko Salomaa; Sangita Kulathinal; Kjell Asplund; François Cambien; Marco Ferrario; Markus Perola; Leena Peltonen; Denis Shields; Hugh Tunstall-Pedoe; Kari Kuulasmaa
MORGAM (an international pooling of cardiovascular cohorts).
International journal of epidemiology 2005;34(1):21-7.
2005: Tero Ylisaukko-Oja; Myriam Peyrard-Janvid; Cecilia M Lindgren; Karola Rehnström; Raija Vanhala; Leena Peltonen; Irma Järvelä; Juha Kere
Family-based association study of DYX1C1 variants in autism.
European journal of human genetics : EJHG 2005;13(1):127-30.
2004: Outi Kopra; Jouni Vesa; Carina von Schantz; Tuula Manninen; Helena Minye; Anna-Liisa Fabritius; Juhani Rapola; Otto P van Diggelen; Janna Saarela; Anu Jalanko; Leena Peltonen
A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging.
Human molecular genetics 2004;13(23):2893-906.
2004: Jesper Ekelund; William Hennah; Tero Hiekkalinna; A Parker; J Meyer; Jouko Lönnqvist; Leena Peltonen
Replication of 1q42 linkage in Finnish schizophrenia pedigrees.
Molecular psychiatry 2004;9(11):1037-41.
2004: Janna Saarela; Carina von Schantz; Leena Peltonen; Anu Jalanko
A novel aspartylglucosaminuria mutation affects translocation of aspartylglucosaminidase.
Human mutation 2004;24(4):350-1.
2004: Heidi E Lilja; Elina Suviolahti; Aino Soro-Paavonen; Tero Hiekkalinna; Aaron Day; Kenneth Lange; Eric Sobel; Marja-Riitta Taskinen; Leena Peltonen; Markus Perola; Päivi Pajukanta
Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.
Journal of lipid research 2004;45(10):1876-84.
2004: Petri Luoma; Atle Melberg; Juha O Rinne; Jyrki A Kaukonen; Nina N Nupponen; Richard M Chalmers; Anders Oldfors; Ilkka Rautakorpi; Leena Peltonen; Kari Majamaa; Hannu Somer; Anu Suomalainen
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.
Lancet 2004;364(9437):875-82.
2004: Tiina Paunio; Annamari Tuulio-Henriksson; Tero Hiekkalinna; Markus Perola; Teppo Varilo; Timo Partonen; Tyrone D Cannon; Jouko Lönnqvist; Leena Peltonen
Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q.
Human molecular genetics 2004;13(16):1693-702.
2004: Daniel C Chen; Janna Saarela; Royden A Clark; Timo Miettinen; Anthony Chi; Evan E Eichler; Leena Peltonen; Aarno Palotie
Segmental duplications flank the multiple sclerosis locus on chromosome 17q.
Genome research 2004;14(8):1483-92.
2004: Jouko Miettunen; Liisa Kantojärvi; Jesper Ekelund; Juha Veijola; Juha T Karvonen; Leena Peltonen; Marjo-Riitta Järvelin; N Freimer; Dirk Lichtermann; Matti Joukamaa
A large population cohort provides normative data for investigation of temperament.
Acta psychiatrica Scandinavica 2004;110(2):150-7.
2004: Ville Holmberg; Anu Jalanko; Juha Isosomppi; Anna-Liisa Fabritius; Leena Peltonen; Outi Kopra
The mouse ortholog of the neuronal ceroid lipofuscinosis CLN5 gene encodes a soluble lysosomal glycoprotein expressed in the developing brain.
Neurobiology of disease 2004;16(1):29-40.
2004: Teppo Varilo; Leena Peltonen
Isolates and their potential use in complex gene mapping efforts.
Current opinion in genetics & development 2004;14(3):316-23.
2004: Päivi Pajukanta; Heidi E Lilja; Janet S Sinsheimer; Rita M Cantor; Aldons J Lusis; Massimiliano Gentile; Xiaoqun Joyce Duan; Aino Soro-Paavonen; Jussi Naukkarinen; Janna Saarela; Markku Laakso; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).
Nature genetics 2004;36(4):371-6.
2004: Leena Peltonen; Johanna Aitta; Samuli Hyvönen; Milja Karjalainen; Jouni Hirvonen
Improved entrapment efficiency of hydrophilic drug substance during nanoprecipitation of poly(l)lactide nanoparticles.
AAPS PharmSciTech 2004;5(1):E16.
2004: Henna Haravuori; H Annika Siitonen; Ibrahim Mahjneh; Peter Hackman; Laura Lahti; Hannu Somer; Leena Peltonen; Marjo Kestilä; Bjarne Udd
Linkage to two separate loci in a family with a novel distal myopathy phenotype (MPD3).
Neuromuscular disorders : NMD 2004;14(3):183-7.
2004: Nina Aula; Outi Kopra; Anu Jalanko; Leena Peltonen
Sialin expression in the CNS implicates extralysosomal function in neurons.
Neurobiology of disease 2004;15(2):251-61.
2004: Peter Kraft; Christina G S Palmer; Arthur J Woodward; Joni A Turunen; Sonia L Minassian; Tiina Paunio; Jouko Lönnqvist; Leena Peltonen; Janet S Sinsheimer
RHD maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order.
European journal of human genetics : EJHG 2004;12(3):192-8.
2004: A Bonetti; Karoliina Reunanen; Saara Finnilä; Keijo Koivisto; Juhani Wikström; Marja-Liisa Sumelahti; T Pirttilä; Irina Elovaara; Mauri Reunanen; Janna Saarela; Leena Peltonen; Terhi Rantamäki; Pentti J Tienari
A two-stage study on multiple sclerosis susceptibility and chromosome 2q33.
Genes and immunity 2004;5(2):142-6.
2004: Janna Saarela; Carita Oinonen; Anu Jalanko; Juha Rouvinen; Leena Peltonen
Autoproteolytic activation of human aspartylglucosaminidase.
The Biochemical journal 2004;378(Pt 2):363-71.
2004: Liisa Keltikangas-Järvinen; Katri Räikkönen; Jesper Ekelund; Leena Peltonen
Nature and nurture in novelty seeking.
Molecular psychiatry 2004;9(3):308-11.
2004: Tero Ylisaukko-Oja; Taina Nieminen-von Wendt; Elli Kempas; Susan Sarenius; Teppo Varilo; Lennart von Wendt; Leena Peltonen; Irma Järvelä
Genome-wide scan for loci of Asperger syndrome.
Molecular psychiatry 2004;9(2):161-8.
2004: Carolina Johansson; Matthäus Willeit; Liviu Aron; Christina Smedh; Jenny Ekholm; Tiina Paunio; Tuula Kieseppä; Dirk Lichtermann; Nicole Praschak-Rieder; Alexander Neumeister; Siegfried Kasper; Leena Peltonen; Rolf Adolfsson; Timo Partonen; Martin Schalling
Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism.
Biological psychiatry 2004;55(3):317-9.
2004: William Hennah; Teppo Varilo; Tiina Paunio; Leena Peltonen
Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia.
Annals of medicine 2004;36(5):322-31.
2003: Elina Suviolahti; Laura J Oksanen; Miina Ohman; Rita M Cantor; Martin Ridderstrale; Tiinamaija Tuomi; Jaakko Kaprio; Aila Rissanen; Pertti Mustajoki; Pekka Jousilahti; Erkki Vartiainen; Kaisa Silander; Riika Kilpikari; Veikko Salomaa; Leif Groop; Kimmo Kontula; Leena Peltonen; Päivi Pajukanta
The SLC6A14 gene shows evidence of association with obesity.
The Journal of clinical investigation 2003;112(11):1762-72.
2003: William Hennah; Teppo Varilo; Marjo Kestilä; Tiina Paunio; Ritva Arajärvi; Jari Haukka; Alex Parker; Rory Martin; Steve Levitzky; Timo Partonen; Joanne Meyer; Jouko Lönnqvist; Leena Peltonen; Jesper Ekelund
Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.
Human molecular genetics 2003;12(23):3151-9.
2003: Daniel C Chen; Janna Saarela; Ilpo Nuotio; Anne Jokiaho; Leena Peltonen; Aarno Palotie
Comparison of GenFlex Tag array and Pyrosequencing in SNP genotyping.
The Journal of molecular diagnostics : JMD 2003;5(4):243-9.
2003: H Annika Siitonen; Outi Kopra; Helena Kääriäinen; Henna Haravuori; Robin M Winter; Anna-Marja Säämänen; Leena Peltonen; Marjo Kestilä
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
Human molecular genetics 2003;12(21):2837-44.
2003: Leena Peltonen
GenomEUtwin: a strategy to identify genetic influences on health and disease.
Twin research : the official journal of the International Society for Twin Studies 2003;6(5):354-60.
2003: Mari Auranen; Teppo Varilo; Reija Alen; Raija Vanhala; K Ayers; Elli Kempas; Tero Ylisaukko-Oja; Leena Peltonen; Irma Järvelä
Evidence for allelic association on chromosome 3q25-27 in families with autism spectrum disorders originating from a subisolate of Finland.
Molecular psychiatry 2003;8(10):879-84.
2003: Juha Paloneva; Jami Mandelin; Anna Kiialainen; Tom Bohling; Johannes Prudlo; Panu Hakola; Matti Haltia; Yrjo T Konttinen; Leena Peltonen
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.
The Journal of experimental medicine 2003;198(4):669-75.
2003: Leena Peltonen; Peter Liljeroth; Tiina Heikkilä; Kyösti Kontturi; Jouni Hirvonen
Dissolution testing of acetylsalicylic acid by a channel flow method-correlation to USP basket and intrinsic dissolution methods.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;19(5):395-401.
2003: Jenny Ekholm; Tuula Kieseppä; Tero Hiekkalinna; Timo Partonen; Tiina Paunio; Markus Perola; Jesper Ekelund; Jouko Lönnqvist; Petra Pekkarinen-Ijäs; Leena Peltonen
Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder.
Human molecular genetics 2003;12(15):1907-15.
2003: Heikki Mannila; M Koivisto; Markus Perola; Teppo Varilo; William Hennah; Jesper Ekelund; M Lukk; Leena Peltonen; Esko Ukkonen
Minimum description length block finder, a method to identify haplotype blocks and to compare the strength of block boundaries.
American journal of human genetics 2003;73(1):86-94.
2003: Liisa Keltikangas-Järvinen; Marko Elovainio; Mika Kivimäki; Dirk Lichtermann; Jesper Ekelund; Leena Peltonen
Association between the type 4 dopamine receptor gene polymorphism and novelty seeking.
Psychosomatic medicine 2003;65(3):471-6.
2003: Carolina Johansson; Matthäus Willeit; Christina Smedh; Jenny Ekholm; Tiina Paunio; Tuula Kieseppä; Dirk Lichtermann; Nicole Praschak-Rieder; Alexander Neumeister; Lars-Göran Nilsson; Siegfried Kasper; Leena Peltonen; Rolf Adolfsson; Martin Schalling; Timo Partonen
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(4):734-9.
2003: Päivi Pajukanta; Hooman Allayee; Kelly L Krass; Ali Kuraishy; Aino Soro; Heidi E Lilja; Rebecca Mar; Marja-Riitta Taskinen; Ilpo Nuotio; Markku Laakso; Jerome I Rotter; Tjerk W A de Bruin; Rita M Cantor; Aldons J Lusis; Leena Peltonen
Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q.
American journal of human genetics 2003;72(4):903-17.
2003: Hannele Pihlaja; Terhi Rantamäki; Juhani Wikström; Marja-Liisa Sumelahti; M Laaksonen; Jorma Ilonen; Juhani Ruutiainen; T Pirttilä; Irina Elovaara; Mauri Reunanen; Satu Kuokkanen; Leena Peltonen; Keijo Koivisto; Pentti J Tienari
Linkage disequilibrium between the MBP tetranucleotide repeat and multiple sclerosis is restricted to a geographically defined subpopulation in Finland.
Genes and immunity 2003;4(2):138-46.
2003: M Koivisto; Markus Perola; Teppo Varilo; William Hennah; Jesper Ekelund; M Lukk; Leena Peltonen; Esko Ukkonen; Heikki Mannila
An MDL method for finding haplotype blocks and for estimating the strength of haplotype block boundaries.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2003;():502-13.
2003: Timothy L Gasperoni; Jesper Ekelund; Matti O Huttunen; Christina G S Palmer; Annamari Tuulio-Henriksson; Jouko Lönnqvist; Jaakko Kaprio; Leena Peltonen; Tyrone D Cannon
Genetic linkage and association between chromosome 1q and working memory function in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003;116B(1):8-16.
2003: Teppo Varilo; Tiina Paunio; Alex Parker; Markus Perola; Joanne Meyer; Joseph D Terwilliger; Leena Peltonen
The interval of linkage disequilibrium (LD) detected with microsatellite and SNP markers in chromosomes of Finnish populations with different histories.
Human molecular genetics 2003;12(1):51-9.
2002: Chris Ramsey; Alex Bukrinsky; Leena Peltonen
Systematic mutagenesis of the functional domains of AIRE reveals their role in intracellular targeting.
Human molecular genetics 2002;11(26):3299-308.
2002: Christina G S Palmer; Joni A Turunen; Janet S Sinsheimer; Sonia L Minassian; Tiina Paunio; Jouko Lönnqvist; Leena Peltonen; J Arthur Woodward
RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility.
American journal of human genetics 2002;71(6):1312-9.
2002: Kaisu Nikali; Juha Saharinen; Leena Peltonen
cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia.
Gene 2002;299(1-2):111-5.
2002: Ilona Visapää; Vineta Fellman; Jouni Vesa; Ayan Dasvarma; Jenna L Hutton; Vijay Kumar; Gregory S Payne; Marja Makarow; Rudy Van Coster; Robert W Taylor; Douglass M Turnbull; Anu Suomalainen; Leena Peltonen
GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L.
American journal of human genetics 2002;71(4):863-76.
2002: Mari Auranen; Raija Vanhala; Teppo Varilo; Kristin Ayers; Elli Kempas; Tero Ylisaukko-Oja; Janet S Sinsheimer; Leena Peltonen; Irma Järvelä
A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27.
American journal of human genetics 2002;71(4):777-90.
2002: Janna Saarela; Marlena Schoenberg Fejzo; Daniel Chen; Saara Finnilä; Maija Parkkonen; Satu Kuokkanen; Eric Sobel; Pentti J Tienari; Marja-Liisa Sumelahti; Juhani Wikström; Irina Elovaara; Keijo Koivisto; Tuula Pirttilä; Mauri Reunanen; Aarno Palotie; Leena Peltonen
Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24.
Human molecular genetics 2002;11(19):2257-67.
2002: Nina Aula; Anu Jalanko; Pertti Aula; Leena Peltonen
Unraveling the molecular pathogenesis of free sialic acid storage disorders: altered targeting of mutant sialin.
Molecular genetics and metabolism 2002;77(1-2):99-107.
2002: Juha Vakkilainen; Päivi Pajukanta; Rita M Cantor; Ilpo Nuotio; Sanni Lahdenperä; Kati Ylitalo; Jussi Pihlajamäki; Petri T Kovanen; Markku Laakso; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia.
European journal of human genetics : EJHG 2002;10(9):547-52.
2002: Peter Hackman; Anna Vihola; Henna Haravuori; Sylvie Marchand; Jaakko Sarparanta; Jérôme de Seze; Siegfried Labeit; Christian Witt; Leena Peltonen; Isabelle Richard; Bjarne Udd
Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin.
American journal of human genetics 2002;71(3):492-500.
2002: Heidi E Lilja; Aino Soro; Kati Ylitalo; Ilpo Nuotio; Jorma S A Viikari; Veikko Salomaa; Erkki Vartiainen; Marja-Riitta Taskinen; Leena Peltonen; Päivi Pajukanta
A candidate gene study in low HDL-cholesterol families provides evidence for the involvement of the APOA2 gene and the APOA1C3A4 gene cluster.
Atherosclerosis 2002;164(1):103-11.
2002: Juha Paloneva; Tuula Manninen; Grant Christman; Karine Hovanes; Jami Mandelin; Rolf Adolfsson; Marino Bianchin; Thomas D Bird; Roxana Miranda; Andrea Salmaggi; Lisbeth Tranebjaerg; Yrjö T Konttinen; Leena Peltonen
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.
American journal of human genetics 2002;71(3):656-62.
2002: Jouni Vesa; Leena Peltonen
Mutated genes in juvenile and variant late infantile neuronal ceroid lipofuscinoses encode lysosomal proteins.
Current molecular medicine 2002;2(5):439-44.
2002: Jouni Vesa; Mark Chin; Kathrin Oelgeschläger; Juha Isosomppi; Esteban C DellAngelica; Anu Jalanko; Leena Peltonen
Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3.
Molecular biology of the cell 2002;13(7):2410-20.
2002: Maria Halonen; Petra Eskelin; Anne Grethe Myhre; Jaakko Perheentupa; Eystein S Husebye; Kämpe Olle; Fredrik Rorsman; Leena Peltonen; Ismo Ulmanen; Jukka Partanen
AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype.
The Journal of clinical endocrinology and metabolism 2002;87(6):2568-74.
2002: Hooman Allayee; Kelly L Krass; Päivi Pajukanta; Rita M Cantor; Carla J H van der Kallen; Rebecca Mar; Jerome I Rotter; Tjerk W A de Bruin; Leena Peltonen; Aldons J Lusis
Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia.
Circulation research 2002;90(8):926-31.
2002: Vineta Fellman; Ilona Visapää; Mihailo Vujic; Ulla-Britt Wennerholm; Leena Peltonen
Antenatal diagnosis of hereditary fetal growth retardation with aminoaciduria, cholestasis, iron overload, and lactic acidosis in the newborn infant.
Acta obstetricia et gynecologica Scandinavica 2002;81(5):398-402.
2002: Karoliina Reunanen; Saara Finnilä; Mikko Laaksonen; Marja-Liisa Sumelahti; Juhani Wikström; Tomi Pastinen; Satu Kuokkanen; Janna Saarela; P Uimari; Juhani Ruutiainen; Jorma Ilonen; Leena Peltonen; Pentti J Tienari
Chromosome 19q13 and multiple sclerosis susceptibility in Finland: a linkage and two-stage association study.
Journal of neuroimmunology 2002;126(1-2):134-42.
2002: Ilona Visapää; Vineta Fellman; Lisa Lanyi; Leena Peltonen
ABCB6 (MTABC3) excluded as the causative gene for the growth retardation syndrome with aminoaciduria, cholestasis, iron overload, and lactacidosis.
American journal of medical genetics 2002;109(3):202-5.
2002: Aino Soro; Päivi Pajukanta; Heidi E Lilja; Kati Ylitalo; Tero Hiekkalinna; Markus Perola; Rita M Cantor; Jorma S A Viikari; Marja-Riitta Taskinen; Leena Peltonen
Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families.
American journal of human genetics 2002;70(5):1333-40.
2002: Juha Isosomppi; Jouni Vesa; Anu Jalanko; Leena Peltonen
Lysosomal localization of the neuronal ceroid lipofuscinosis CLN5 protein.
Human molecular genetics 2002;11(8):885-91.
2002: Maija Wessman; Mikko Kallela; Mari A Kaunisto; Pia Marttila; Eric Sobel; Jaana Hartiala; Greg Oswell; Suzanne M Leal; Jeanette C Papp; Eija Hämäläinen; Petra Broas; Geoffrey Joslyn; Iiris Hovatta; Tero Hiekkalinna; Jaakko Kaprio; Jürg Ott; Rita M Cantor; John-Anker Zwart; Matti Ilmavirta; Hannele Havanka; Markus Färkkilä; Leena Peltonen; Aarno Palotie
A susceptibility locus for migraine with aura, on chromosome 4q24.
American journal of human genetics 2002;70(3):652-62.
2002: Chris Ramsey; Ola Winqvist; Lea Puhakka; Maria Halonen; Aune Moro; Kämpe Olle; Petra Eskelin; Markku Pelto-Huikko; Leena Peltonen
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response.
Human molecular genetics 2002;11(4):397-409.
2002: Nabil Sabri Enattah; Timo Sahi; Erkki Savilahti; Joseph D Terwilliger; Leena Peltonen; Irma Järvelä
Identification of a variant associated with adult-type hypolactasia.
Nature genetics 2002;30(2):233-7.
2002: Leena Peltonen; Piritta Koistinen; Milja Karjalainen; Antti Häkkinen; Jouni Hirvonen
The effect of cosolvents on the formulation of nanoparticles from low-molecular-weight poly(l)lactide.
AAPS PharmSciTech 2002;3(4):E32.
2002: G Hu; Barmak Modrek; H M F Riise Stensland; Janna Saarela; Päivi Pajukanta; Vlad Kustanovich; Leena Peltonen; Stanley F Nelson; Christopher Lee
Efficient discovery of single-nucleotide polymorphisms in coding regions of human genes.
The pharmacogenomics journal 2002;2(4):236-42.
2002: Jenny Ekholm; P Pekkarinen; Päivi Pajukanta; Tuula Kieseppä; Timo Partonen; Tiina Paunio; Teppo Varilo; Markus Perola; Jouko Lönnqvist; Leena Peltonen
Bipolar disorder susceptibility region on Xq24-q27.1 in Finnish families.
Molecular psychiatry 2002;7(5):453-9.
2001: Tiina Paunio; Jesper Ekelund; Teppo Varilo; Alex Parker; Iiris Hovatta; Joni A Turunen; K Rinard; A Foti; Joseph D Terwilliger; Hannu Juvonen; Jaana Suvisaari; Ritva Arajärvi; Jaana Suokas; Timo Partonen; Jouko Lönnqvist; Joanne Meyer; Leena Peltonen
Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q.
Human molecular genetics 2001;10(26):3037-48.
2001: Tomi Pastinen; Markus Perola; Jaakko Ignatius; C Sabatti; Päivi Tainola; M Levander; Ann-Christine Syvänen; Leena Peltonen
Dissecting a population genome for targeted screening of disease mutations.
Human molecular genetics 2001;10(26):2961-72.
2001: Jesper Ekelund; Iiris Hovatta; Alex Parker; Tiina Paunio; Teppo Varilo; R Martin; J Suhonen; Pekka Ellonen; G Chan; Janet S Sinsheimer; Eric Sobel; Hannu Juvonen; Ritva Arajärvi; Timo Partonen; Jaana Suvisaari; Jouko Lönnqvist; Joanne Meyer; Leena Peltonen
Chromosome 1 loci in Finnish schizophrenia families.
Human molecular genetics 2001;10(15):1611-7.
2001: Markus Perola; Miina Ohman; Tero Hiekkalinna; J Leppävuori; Päivi Pajukanta; Maija Wessman; M Koskenvuo; Aarno Palotie; Kenneth Lange; Jaakko Kaprio; Leena Peltonen
Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups.
American journal of human genetics 2001;69(1):117-23.
2001: Janna Saarela; M Laine; Carita Oinonen; C von Schantz; Anu Jalanko; Juha Rouvinen; Leena Peltonen
Molecular pathogenesis of a disease: structural consequences of aspartylglucosaminuria mutations.
Human molecular genetics 2001;10(9):983-95.
2001: Henna Haravuori; Anna Vihola; Volker Straub; Mari Auranen; Isabelle Richard; Sylvie Marchand; T Voit; Siegfried Labeit; Hannu Somer; Leena Peltonen; Jacques Beckmann; Bjarne Udd
Secondary calpain3 deficiency in 2q-linked muscular dystrophy: titin is the candidate gene.
Neurology 2001;56(7):869-77.
2001: Carolina Johansson; Christina Smedh; Timo Partonen; P Pekkarinen; Tiina Paunio; Jenny Ekholm; Leena Peltonen; Dirk Lichtermann; J Palmgren; Rolf Adolfsson; Martin Schalling
Seasonal affective disorder and serotonin-related polymorphisms.
Neurobiology of disease 2001;8(2):351-7.
2001: Mari Auranen; Raija Vanhala; M Vosman; M Levander; Teppo Varilo; M Hietala; Raili Riikonen; Leena Peltonen; Irma Järvelä
MECP2 gene analysis in classical Rett syndrome and in patients with Rett-like features.
Neurology 2001;56(5):611-7.
2001: Päivi Pajukanta; Jackie S Bodnar; Riitta Sallinen; M Chu; T Airaksinen; Q Xiao; Lawrence W Castellani; Sonal S Sheth; Maija Wessman; Aarno Palotie; Janet S Sinsheimer; Peter Demant; Aldons J Lusis; Leena Peltonen
Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.
Mammalian genome : official journal of the International Mammalian Genome Society 2001;12(3):238-45.
2001: Leena Peltonen; Victor A McKusick
Genomics and medicine. Dissecting human disease in the postgenomic era.
Science (New York, N.Y.) 2001;291(5507):1224-9.
2001: Maria Halonen; Markku Pelto-Huikko; Petra Eskelin; Leena Peltonen; Ismo Ulmanen; Meelis Kolmer
Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED).
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(2):197-208.
2000: Leena Peltonen; A Palotie; K Lange
Use of population isolates for mapping complex traits.
Nature reviews. Genetics 2000;1(3):182-90.
2000: Päivi Pajukanta; M Cargill; Laura Viitanen; Ilpo Nuotio; Anu Kareinen; Markus Perola; Joseph D Terwilliger; E Kempas; Mark J Daly; Heidi E Lilja; JD Rioux; T Brettin; Jorma S A Viikari; T Rönnemaa; Markku Laakso; Eric S Lander; Leena Peltonen
Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.
American journal of human genetics 2000;67(6):1481-93.
2000: Markus Perola; K Kainulainen; Päivi Pajukanta; Joseph D Terwilliger; Tero Hiekkalinna; Pekka Ellonen; Jaakko Kaprio; Markku Koskenvuo; Kimmo Kontula; Leena Peltonen
Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings.
Journal of hypertension 2000;18(11):1579-85.
2000: Outi Kopra; Tarja Salonen; Anu Jalanko; Leena Peltonen; A Copp
CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain.
The Journal of comparative neurology 2000;426(3):406-12.
2000: Nina Aula; P Salomäki; R Timonen; Frans W Verheijen; G Mancini; J E Månsson; Pertti Aula; Leena Peltonen
The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation.
American journal of human genetics 2000;67(4):832-40.
2000: Miina Ohman; Laura J Oksanen; Jaakko Kaprio; Markku Koskenvuo; Pertti Mustajoki; Aila Rissanen; J Salmi; Kimmo Kontula; Leena Peltonen
Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24.
The Journal of clinical endocrinology and metabolism 2000;85(9):3183-90.
2000: V Holmberg; Leena Lauronen; Taina Autti; Pirkko Santavuori; M Savukoski; P Uvebrant; IL Hofman; Leena Peltonen; Irma Järvelä
Phenotype-genotype correlation in eight patients with Finnish variant late infantile NCL (CLN5).
Neurology 2000;55(4):579-81.
2000: Jyrki A Kaukonen; J K Juselius; Valeria Tiranti; Aija Kyttälä; M Zeviani; G P Comi; Sirkka Keränen; Leena Peltonen; Anu Suomalainen
Role of adenine nucleotide translocator 1 in mtDNA maintenance.
Science (New York, N.Y.) 2000;289(5480):782-5.
2000: Sami Mustajoki; M Laine; M Lahtela; Pertti Mustajoki; Leena Peltonen; Raili Kauppinen
Acute intermittent porphyria: expression of mutant and wild-type porphobilinogen deaminase in COS-1 cells.
Molecular medicine (Cambridge, Mass.) 2000;6(8):670-9.
2000: Teppo Varilo; Maris Laan; Iiris Hovatta; Victor Wiebe; Joseph D Terwilliger; Leena Peltonen
Linkage disequilibrium in isolated populations: Finland and a young sub-population of Kuusamo.
European journal of human genetics : EJHG 2000;8(8):604-12.
2000: Tomi Pastinen; M Raitio; Katarina Lindroos; Päivi Tainola; Leena Peltonen; Ann-Christine Syvänen
A system for specific, high-throughput genotyping by allele-specific primer extension on microarrays.
Genome research 2000;10(7):1031-42.
2000: Juha Paloneva; Marjo Kestilä; J Wu; A Salminen; T Böhling; Vesa Ruotsalainen; Panu Hakola; AB Bakker; J H Phillips; P Pekkarinen; Lewis L Lanier; T Timonen; Leena Peltonen
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.
Nature genetics 2000;25(3):357-61.
2000: Leena Peltonen; M Savukoski; Jouni Vesa
Genetics of the neuronal ceroid lipofuscinoses.
Current opinion in genetics & development 2000;10(3):299-305.
2000: Mari Auranen; T Nieminen; S Majuri; Raija Vanhala; Leena Peltonen; Irma Järvelä
Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families.
Molecular psychiatry 2000;5(3):320-2.
2000: Jesper Ekelund; Dirk Lichtermann; Iiris Hovatta; Pekka Ellonen; Jaana Suvisaari; Joseph D Terwilliger; Hannu Juvonen; Teppo Varilo; Ritva Arajärvi; ML Kokko-Sahin; Jouko Lönnqvist; Leena Peltonen
Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22.
Human molecular genetics 2000;9(7):1049-57.
2000: E Virolainen; Maija Wessman; Iiris Hovatta; Katri Niemi; Jaakko Ignatius; Juha Kere; Leena Peltonen; Aarno Palotie
Assignment of a novel locus for autosomal recessive congenital ichthyosis to chromosome 19p13.1-p13.2.
American journal of human genetics 2000;66(3):1132-7.
2000: Outi Kopra; Aija Kyttälä; E Lehmus; Tiina Paunio; Leena Peltonen; Anu Jalanko
Expression of palmitoyl protein thioesterase in neurons.
Molecular genetics and metabolism 2000;69(2):123-9.
2000: P Björses; Maria Halonen; J J Palvimo; Meelis Kolmer; Jaakko Aaltonen; Pekka Ellonen; Jaakko Perheentupa; Ismo Ulmanen; Leena Peltonen
Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein.
American journal of human genetics 2000;66(2):378-92.
2000: Tarja Salonen; Irma Järvelä; Leena Peltonen; Anu Jalanko
Detection of eight novel palmitoyl protein thioesterase (PPT) mutations underlying infantile neuronal ceroid lipofuscinosis (INCL;CLN1).
Human mutation 2000;15(3):273-9.
1999: Juha Isosomppi; Outi Kopra; Jukka O Hiltunen; Nicholas D E Greene; Jouni Vesa; A Uusitalo; Hannah M Mitchison; Mart Saarma; Anu Jalanko; Leena Peltonen
Developmental expression of palmitoyl protein thioesterase in normal mice.
Brain research. Developmental brain research 1999;118(1-2):1-11.
1999: Frans W Verheijen; Elly Verbeek; Nina Aula; Cecile E M T Beerens; AC Havelaar; Marijke Joosse; Leena Peltonen; Pertti Aula; H Galjaard; Peter van der Spek; Grazia M S Mancini
A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases.
Nature genetics 1999;23(4):462-5.
1999: Iiris Hovatta; Teppo Varilo; Jaana Suvisaari; Joseph D Terwilliger; Vesa Ollikainen; Ritva Arajärvi; Hannu Juvonen; ML Kokko-Sahin; L Väisänen; Heikki Mannila; Jouko Lönnqvist; Leena Peltonen
A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci.
American journal of human genetics 1999;65(4):1114-24.
1999: Ilona Visapää; Riitta Salonen; Teppo Varilo; P Paavola; Leena Peltonen
Assignment of the locus for hydrolethalus syndrome to a highly restricted region on 11q23-25.
American journal of human genetics 1999;65(4):1086-95.
1999: J Leppävuori; U Kujala; Jaakko Kinnunen; Jaakko Kaprio; M Nissilä; M Heliövaara; N Klinger; J Partanen; Joseph D Terwilliger; Leena Peltonen
Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q.
American journal of human genetics 1999;65(4):1060-7.
1999: Urho M Kujala; J Leppävuori; Jaakko Kaprio; Jaakko Kinnunen; Leena Peltonen; Markku Koskenvuo
Joint-specific twin and familial aggregation of recalled physician diagnosed osteoarthritis.
Twin research : the official journal of the International Society for Twin Studies 1999;2(3):196-202.
1999: Jesper Ekelund; Dirk Lichtermann; Marjo-Riitta Järvelin; Leena Peltonen
Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample.
The American journal of psychiatry 1999;156(9):1453-5.
1999: M Laine; J Richter; C Fahlman; Juhani Rapola; Martin Renlund; Leena Peltonen; S Karlsson; Anu Jalanko
Correction of peripheral lysosomal accumulation in mice with aspartylglucosaminuria by bone marrow transplantation.
Experimental hematology 1999;27(9):1467-74.
1999: A Uusitalo; K Tenhunen; Outi Kopra; Jukka O Hiltunen; M Saarma; Matti Haltia; Anu Jalanko; Leena Peltonen
Toward understanding the neuronal pathogenesis of aspartylglucosaminuria: expression of aspartylglucosaminidase in brain during development.
Molecular genetics and metabolism 1999;67(4):294-307.
1999: Hannele Kangas; Ismo Ulmanen; Tiina Paunio; D J Kwiatkowski; M Lehtovirta; Anu Jalanko; Leena Peltonen
Functional consequences of amyloidosis mutation for gelsolin polypeptide -- analysis of gelsolin-actin interaction and gelsolin processing in gelsolin knock-out fibroblasts.
FEBS letters 1999;454(3):233-9.
1999: T Klockars; V Holmberg; M Savukoski; Eric S Lander; Leena Peltonen
Transcript identification on the CLN5 region on chromosome 13q22.
Human genetics 1999;105(1-2):51-6.
1999: Jyrki A Kaukonen; M Zeviani; G P Comi; M G Piscaglia; Leena Peltonen; Anu Suomalainen
A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia.
American journal of human genetics 1999;65(1):256-61.
1999: Päivi Pajukanta; Joseph D Terwilliger; Markus Perola; Tero Hiekkalinna; Ilpo Nuotio; Pekka Ellonen; Maija Parkkonen; Jaana Hartiala; Kati Ylitalo; Jussi Pihlajamäki; Kimmo Porkka; Markku Laakso; Jorma Viikari; Christian Ehnholm; Marja-Riitta Taskinen; Leena Peltonen
Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.
American journal of human genetics 1999;64(5):1453-63.
1999: Bradley E Aouizerat; Hooman Allayee; Jackie S Bodnar; Kelly L Krass; Leena Peltonen; Tjerk W A de Bruin; Jerome I Rotter; Aldons J Lusis
Novel genes for familial combined hyperlipidemia.
Current opinion in lipidology 1999;10(2):113-22.
1999: T Klockars; M Savukoski; Juha Isosomppi; Leena Peltonen
Positional cloning of the CLN5 gene defective in the Finnish variant of the LINCL.
Molecular genetics and metabolism 1999;66(4):324-8.
1999: T Rantamäki; I Kaitila; Ann-Christine Syvänen; M Lukka; Leena Peltonen
Recurrence of Marfan syndrome as a result of parental germ-line mosaicism for an FBN1 mutation.
American journal of human genetics 1999;64(4):993-1001.
1999: K Kainulainen; Markus Perola; Joseph D Terwilliger; Jaakko Kaprio; Markku Koskenvuo; Ann-Christine Syvänen; E Vartiainen; Leena Peltonen; Kimmo Kontula
Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension.
Hypertension 1999;33(3):844-9.
1999: P Paavola; Kristiina Avela; Nina Horelli-Kuitunen; Maarit Bärlund; Anne Kallioniemi; N Idänheimo; M Kyttälä; Albert de La Chapelle; Aarno Palotie; Anna-Elina Lehesjoki; Leena Peltonen
High-resolution physical and genetic mapping of the critical region for Meckel syndrome and Mulibrey Nanism on chromosome 17q22-q23.
Genome research 1999;9(3):267-76.
1999: Miina Ohman; Laura J Oksanen; K Kainulainen; O A Jänne; Jaakko Kaprio; Markku Koskenvuo; Pertti Mustajoki; Kimmo Kontula; Leena Peltonen
Testing of human homologues of murine obesity genes as candidate regions in Finnish obese sib pairs.
European journal of human genetics : EJHG 1999;7(2):117-24.
1999: Ulla Wartiovaara; Markus Perola; H Mikkola; K Tötterman; Vesa Savolainen; Antti Penttilä; P J Grant; Matti J Tikkanen; Erkki Vartiainen; Pekka J Karhunen; Leena Peltonen; Aarno Palotie
Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males.
Atherosclerosis 1999;142(2):295-300.
1999: P Björses; Markku Pelto-Huikko; J Kaukonen; Jaakko Aaltonen; Leena Peltonen; Ismo Ulmanen
Localization of the APECED protein in distinct nuclear structures.
Human molecular genetics 1999;8(2):259-66.
1999: Leena Peltonen; Anu Jalanko; Teppo Varilo
Molecular genetics of the Finnish disease heritage.
Human molecular genetics 1999;8(10):1913-23.
1999: Nina Horelli-Kuitunen; Jaakko Aaltonen; Marie-Laure Yaspo; Mervi Eeva; Maija Wessman; Leena Peltonen; Aarno Palotie
Mapping ESTs by fiber-FISH.
Genome research 1999;9(1):62-71.
1999: P Paavola; Nina Horelli-Kuitunen; Aarno Palotie; Leena Peltonen
Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene.
Genomics 1999;55(1):122-5.
1998: K Tenhunen; A Uusitalo; Taina Autti; Raimo Joensuu; M Kettunen; Risto A Kauppinen; S Ikonen; Mary E LaMarca; Matti Haltia; Edward I Ginns; Anu Jalanko; Leena Peltonen
Monitoring the CNS pathology in aspartylglucosaminuria mice.
Journal of neuropathology and experimental neurology 1998;57(12):1154-63.
1998: P Pekkarinen; Marjo Kestilä; Juha Paloneva; J Terwillign; Teppo Varilo; O Järvi; Panu Hakola; Leena Peltonen
Fine-scale mapping of a novel dementia gene, PLOSL, by linkage disequilibrium.
Genomics 1998;54(2):307-15.
1998: L Lönnqvist; D Reinhardt; L Sakai; Leena Peltonen
Evidence for furin-type activity-mediated C-terminal processing of profibrillin-1 and interference in the processing by certain mutations.
Human molecular genetics 1998;7(13):2039-44.
1998: Ilona Visapää; Vineta Fellman; Teppo Varilo; Aarno Palotie; Kari O Raivio; Leena Peltonen
Assignment of the locus for a new lethal neonatal metabolic syndrome to 2q33-37.
American journal of human genetics 1998;63(5):1396-403.
1998: Nina Järvinen; P Mäkelä-Bengs; Anu Suomalainen; Katri Vuopala; Riitta Herva; Aarno Palotie; Leena Peltonen
LCCS: a lethal motoneuron disease of the fetus maps to chromosome 9q34.
Annals of the New York Academy of Sciences 1998;857():260-2.
1998: M Peltola; Aija Kyttälä; Outi Kopra; Juhani Rapola; Tiina Paunio; F Revah; Leena Peltonen; Anu Jalanko
Adenovirus-mediated gene transfer results in decreased lysosomal storage in brain and total correction in liver of aspartylglucosaminuria (AGU) mouse.
Gene therapy 1998;5(10):1314-21.
1998: Dirk Lichtermann; Iiris Hovatta; Joseph D Terwilliger; Leena Peltonen; Jouko Lönnqvist
Concordance for sex and the pseudoautosomal gene hypothesis revisited: no evidence of increased sex concordance in a nationwide Finnish sample of siblings with paternally derived schizophrenia.
The American journal of psychiatry 1998;155(10):1365-75.
1998: Irma Järvelä; Nabil Sabri Enattah; J Kokkonen; Teppo Varilo; Erkki Savilahti; Leena Peltonen
Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene.
American journal of human genetics 1998;63(4):1078-85.
1998: Aija Kyttälä; Outi Kopra; Leena Peltonen; Anu Jalanko
Expression and endocytosis of lysosomal aspartylglucosaminidase in mouse primary neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(19):7750-6.
1998: Janna Saarela; M Laine; R Tikkanen; Carita Oinonen; Anu Jalanko; Juha Rouvinen; Leena Peltonen
Activation and oligomerization of aspartylglucosaminidase.
The Journal of biological chemistry 1998;273(39):25320-8.
1998: Iiris Hovatta; Dirk Lichtermann; Hannu Juvonen; Jaana Suvisaari; Joseph D Terwilliger; Ritva Arajärvi; ML Kokko-Sahin; Jesper Ekelund; Jouko Lönnqvist; Leena Peltonen
Linkage analysis of putative schizophrenia gene candidate regions on chromosomes 3p, 5q, 6p, 8p, 20p and 22q in a population-based sampled Finnish family set.
Molecular psychiatry 1998;3(5):452-7.
1998: Tomi Pastinen; Markus Perola; P Niini; Joseph D Terwilliger; Veikko Salomaa; E Vartiainen; Leena Peltonen; Ann-Christine Syvänen
Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population.
Human molecular genetics 1998;7(9):1453-62.
1998: P Mäkelä-Bengs; Nina Järvinen; Katri Vuopala; Anu Suomalainen; Jaakko Ignatius; M Sipilä; Riitta Herva; Aarno Palotie; Leena Peltonen
Assignment of the disease locus for lethal congenital contracture syndrome to a restricted region of chromosome 9q34, by genome scan using five affected individuals.
American journal of human genetics 1998;63(2):506-16.
1998: Outi Kopra; E Hellsten; N Horelli-Kuitunen; Leena Peltonen; Anu Jalanko
Mouse palmitoyl protein thioesterase: gene structure and expression of cDNA.
Genome research 1998;8(7):724-30.
1998: M Savukoski; T Klockars; V Holmberg; Pirkko Santavuori; Eric S Lander; Leena Peltonen
CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis.
Nature genetics 1998;19(3):286-8.
1998: Tiina Paunio; Hannele Kangas; Outi Kopra; M H Buc-Caron; jean-jacques robert; S Kaasinen; Ilkka Julkunen; J Mallet; Leena Peltonen
Cells of the neuronal lineage play a major role in the generation of amyloid precursor fragments in gelsolin-related amyloidosis.
The Journal of biological chemistry 1998;273(26):16319-24.
1998: Bjarne Udd; Henna Haravuori; Hannu Kalimo; Jukka Partanen; L Pulkkinen; Anders Paetau; Leena Peltonen; Hannu Somer
Tibial muscular dystrophy--from clinical description to linkage on chromosome 2q31.
Neuromuscular disorders : NMD 1998;8(5):327-32.
1998: Päivi Pajukanta; Ilpo Nuotio; Joseph D Terwilliger; Kimmo Porkka; Kati Ylitalo; Jussi Pihlajamäki; Anu Suomalainen; Ann-Christine Syvänen; T Lehtimäki; Jorma S A Viikari; Markku Laakso; Marja-Riitta Taskinen; Christian Ehnholm; Leena Peltonen
Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23.
Nature genetics 1998;18(4):369-73.
1998: Marjo Kestilä; U Lenkkeri; Minna Männikkö; Jane Lamerdin; P McCready; H Putaala; Vesa Ruotsalainen; T Morita; Marja Nissinen; Riitta Herva; C E Kashtan; Leena Peltonen; Christer Holmberg; A Olsen; Karl Tryggvason
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.
Molecular cell 1998;1(4):575-82.
1998: Henna Haravuori; P Mäkelä-Bengs; Bjarne Udd; Jukka Partanen; L Pulkkinen; Hannu Somer; Leena Peltonen
Assignment of the tibial muscular dystrophy locus to chromosome 2q31.
American journal of human genetics 1998;62(3):620-6.
1998: P Pekkarinen; Iiris Hovatta; Panu Hakola; O Järvi; Marjo Kestilä; U Lenkkeri; Rolf Adolfsson; Gösta Holmgren; Per-Olof Nylander; Lisbeth Tranebjaerg; Joseph D Terwilliger; Jouko Lönnqvist; Leena Peltonen
Assignment of the locus for PLO-SL, a frontal-lobe dementia with bone cysts, to 19q13.
American journal of human genetics 1998;62(2):362-72.
1998: Anu Jalanko; K Tenhunen; CE McKinney; Mary E LaMarca; Juhani Rapola; Taina Autti; Raimo Joensuu; Tuula Manninen; I Sipilä; S Ikonen; P Riekkinen; Edward I Ginns; Leena Peltonen
Mice with an aspartylglucosaminuria mutation similar to humans replicate the pathophysiology in patients.
Human molecular genetics 1998;7(2):265-72.
1998: P Björses; Jaakko Aaltonen; Nina Horelli-Kuitunen; Marie-Laure Yaspo; Leena Peltonen
Gene defect behind APECED: a new clue to autoimmunity.
Human molecular genetics 1998;7(10):1547-53.
1998: Pentti J Tienari; Satu Kuokkanen; Tomi Pastinen; Juhani Wikström; Antti Sajantila; M Sandberg-Wollheim; Jukka U Palo; Leena Peltonen
Golli-MBP gene in multiple sclerosis susceptibility.
Journal of neuroimmunology 1998;81(1-2):158-67.
1998: L Karttunen; T Ukkonen; K Kainulainen; Ann-Christine Syvänen; Leena Peltonen
Two novel fibrillin-1 mutations resulting in premature termination codons but in different mutant transcript levels and clinical phenotypes.
Human mutation 1998;Suppl 1():S34-7.
1998: Irma Järvelä; Markku Sainio; T Rantamäki; V M Olkkonen; Olli Carpén; Leena Peltonen; Anu Jalanko
Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease.
Human molecular genetics 1998;7(1):85-90.
1997: Leena Peltonen
Molecular background of the Finnish disease heritage.
Annals of medicine 1997;29(6):553-6.
1997: Satu Kuokkanen; M Gschwend; JD Rioux; Mark J Daly; Joseph D Terwilliger; Pentti J Tienari; Juhani Wikström; Jukka U Palo; L D Stein; T J Hudson; Eric S Lander; Leena Peltonen
Genomewide scan of multiple sclerosis in Finnish multiplex families.
American journal of human genetics 1997;61(6):1379-87.
1997: R Tikkanen; M Peltola; Carita Oinonen; Juha Rouvinen; Leena Peltonen
Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase.
The EMBO journal 1997;16(22):6684-93.
1997: T Rantamäki; L Karttunen; Leena Peltonen
Badly engineered fibrillin lessons from molecular studies of marfan syndrome.
Trends in cardiovascular medicine 1997;7(8):282-8.
1997: P Paavola; Riitta Salonen; A Baumer; A Schinzel; P A Boyd; S Gould; H Meusburger; Romano Tenconi; A Barnicoat; R Winter; Leena Peltonen
Clinical and genetic heterogeneity in Meckel syndrome.
Human genetics 1997;101(1):88-92.
1997: Sami Mustajoki; Raili Kauppinen; Pertti Mustajoki; Anu Suomalainen; Leena Peltonen
Steady-state transcript levels of the porphobilinogen deaminase gene in patients with acute intermittent porphyria.
Genome research 1997;7(11):1054-60.
1997: K Wansen; Tomi Pastinen; Satu Kuokkanen; Juhani Wikström; Jukka U Palo; Leena Peltonen; Pentti J Tienari
Immune system genes in multiple sclerosis: genetic association and linkage analyses on TCR beta, IGH, IFN-gamma and IL-1ra/IL-1 beta loci.
Journal of neuroimmunology 1997;79(1):29-36.
1997: T Klockars; Juha Isosomppi; Maris Laan; N Kakko; Aarno Palotie; Leena Peltonen
The visual assignment of genes by fiber-fish: BTF3 protein homologue gene (BTF3) and a novel pseudogene of human RNA helicase A (DDX9P) on 13q22.
Genomics 1997;44(3):355-7.
1997: Kimmo Porkka; Ilpo Nuotio; Päivi Pajukanta; Christian Ehnholm; L Suurinkeroinen; Mikko Syvänne; Terho Lehtimäki; Anne-Tiina Lahdenkari; Sanni Lahdenperä; Kati Ylitalo; Marjatta Antikainen; Markus Perola; Olli T Raitakari; Petri T Kovanen; Jorma S A Viikari; Leena Peltonen; Marja-Riitta Taskinen
Phenotype expression in familial combined hyperlipidemia.
Atherosclerosis 1997;133(2):245-53.
1997: Jaakko Aaltonen; Nina Horelli-Kuitunen; J B Fan; P Björses; Jaakko Perheentupa; Richard Myers; Aarno Palotie; Leena Peltonen
High-resolution physical and transcriptional mapping of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy locus on chromosome 21q22.3 by FISH.
Genome research 1997;7(8):820-9.
1997: Leena Peltonen; A Uusitalo
Rare disease genes--lessons and challenges.
Genome research 1997;7(8):765-7.
1997: Iiris Hovatta; Joseph D Terwilliger; Dirk Lichtermann; T Mäkikyrö; Jaana Suvisaari; Leena Peltonen; Jouko Lönnqvist
Schizophrenia in the genetic isolate of Finland.
American journal of medical genetics 1997;74(4):353-60.
1997: Kirmo Wartiovaara; P Paavola; P Suvanto; L Paulin; Mart Saarma; Leena Peltonen; Hannu Sariola
Exclusion of the p75 neurotrophin receptor gene as a candidate gene for Meckel syndrome.
Clinical dysmorphology 1997;6(3):213-7.
1997: Tomi Pastinen; Ants Kurg; Andres Metspalu; Leena Peltonen; Ann-Christine Syvänen
Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays.
Genome research 1997;7(6):606-14.
1997: Päivi Pajukanta; Kimmo Porkka; Marjatta Antikainen; Marja-Riitta Taskinen; Markus Perola; S Murtomäki-Repo; Sonja Jaari; Ilpo Nuotio; L Suurinkeroinen; Anne-Tiina Lahdenkari; Ann-Christine Syvänen; Jorma S A Viikari; Christian Ehnholm; Leena Peltonen
No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(5):841-50.
1997: Anu Suomalainen; A Majander; M Wallin; Kirsi Setälä; Kimmo Kontula; H Leinonen; T Salmi; Anders Paetau; Matti Haltia; Leena Valanne; J Lonnqvist; Leena Peltonen; Hannu Somer
Autosomal dominant progressive external ophthalmoplegia with multiple deletions of mtDNA: clinical, biochemical, and molecular genetic features of the 10q-linked disease.
Neurology 1997;48(5):1244-53.
1997: Laura J Oksanen; Miina Ohman; M Heiman; K Kainulainen; Jaakko Kaprio; Pertti Mustajoki; Veikko Koivisto; Markku Koskenvuo; O A Jänne; Leena Peltonen; Kimmo Kontula
Markers for the gene ob and serum leptin levels in human morbid obesity.
Human genetics 1997;99(5):559-64.
1997: Tiina Paunio; Hannele Kangas; S Kiuru; Jukka U Palo; Leena Peltonen; Ann-Christine Syvänen
Tissue distribution and levels of gelsolin mRNA in normal individuals and patients with gelsolin-related amyloidosis.
FEBS letters 1997;406(1-2):49-55.
1997: A Uusitalo; K Tenhunen; J Tenhunen; S Matikainen; Leena Peltonen; Anu Jalanko
Expression and regulation of the human and mouse aspartylglucosaminidase gene.
The Journal of biological chemistry 1997;272(14):9524-30.
1997: Päivi Pajukanta; Leena Peltonen
How to tackle genetic loci predisposing to atherosclerosis?
Current opinion in lipidology 1997;8(2):95-100.
1997: Kati Ylitalo; Kimmo Porkka; Seppo Meri; Ilpo Nuotio; L Suurinkeroinen; Juha Vakkilainen; Päivi Pajukanta; Jorma S A Viikari; Leena Peltonen; Christian Ehnholm; Marja-Riitta Taskinen
Serum complement and familial combined hyperlipidemia.
Atherosclerosis 1997;129(2):271-7.
1997: Minna Männikkö; Marjo Kestilä; U Lenkkeri; H Alakurtti; Christer Holmberg; Jaakko Leisti; Riitta Salonen; P Aula; A Mustonen; Leena Peltonen; Karl Tryggvason
Improved prenatal diagnosis of the congenital nephrotic syndrome of the Finnish type based on DNA analysis.
Kidney international 1997;51(3):868-72.
1997: H Mikkola; László Muszbek; E Laiho; Martti Syrjälä; Eija Hämäläinen; Gizella Haramura; T Salmi; Leena Peltonen; Aarno Palotie
Molecular mechanism of a mild phenotype in coagulation factor XIII (FXIII) deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA.
Blood 1997;89(4):1279-87.
1997: E Hellsten; Jouni Vesa; Anu Jalanko; Leena Peltonen
From locus to cellular disturbances: positional cloning of the infantile neuronal ceroid lipofuscinosis gene.
Neuropediatrics 1997;28(1):9-11.
1997: Kaisu Nikali; Juha Isosomppi; Tuula Lönnqvist; J I Mao; Anu Suomalainen; Leena Peltonen
Toward cloning of a novel ataxia gene: refined assignment and physical map of the IOSCA locus (SCA8) on 10q24.
Genomics 1997;39(2):185-91.
1996: Laura J Oksanen; Pertti Mustajoki; Jaakko Kaprio; K Kainulainen; O Jänne; Leena Peltonen; Kimmo Kontula
Polymorphism of the beta 3-adrenergic receptor gene in morbid obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(12):1055-61.
1996: P Leppänen; J Isosomppi; J Schleutker; Pertti Aula; Leena Peltonen
A physical map of the 6q14-q15 region harboring the locus for the lysosomal membrane sialic acid transport defect.
Genomics 1996;37(1):62-7.
1996: M Heiskanen; Leena Peltonen; A Palotif
Visual mapping by high resolution FISH.
Trends in genetics : TIG 1996;12(10):379-82.
1996: M Laan; Juha Isosomppi; T Klockars; Leena Peltonen; Aarno Palotie
Utilization of FISH in positional cloning: an example on 13q22.
Genome research 1996;6(10):1002-12.
1996: E Hellsten; Jouni Vesa; V M Olkkonen; Anu Jalanko; Leena Peltonen
Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis.
The EMBO journal 1996;15(19):5240-5.
1996: P Björses; Jaakko Aaltonen; A Vikman; J Perheentupa; G Ben-Zion; G Chiumello; N Dahl; P Heideman; J J Hoorweg-Nijman; L Mathivon; P E Mullis; M Pohl; M Ritzen; Giovanni Romeo; M S Shapiro; C S Smith; János Sólyom; J Zlotogora; Leena Peltonen
Genetic homogeneity of autoimmune polyglandular disease type I.
American journal of human genetics 1996;59(4):879-86.
1996: L Lönnqvist; L Karttunen; T Rantamäki; Cay M Kielty; Michael Raghunath; Leena Peltonen
A point mutation creating an extra N-glycosylation site in fibrillin-1 results in neonatal Marfan syndrome.
Genomics 1996;36(3):468-75.
1996: Teppo Varilo; Kaisu Nikali; Anu Suomalainen; Tuula Lönnqvist; Leena Peltonen
Tracing an ancestral mutation: genealogical and haplotype analysis of the infantile onset spinocerebellar ataxia locus.
Genome research 1996;6(9):870-5.
1996: Hannele Kangas; Tiina Paunio; N Kalkkinen; Anu Jalanko; Leena Peltonen
In vitro expression analysis shows that the secretory form of gelsolin is the sole source of amyloid in gelsolin-related amyloidosis.
Human molecular genetics 1996;5(9):1237-43.
1996: Marja Hietala; Pertti Aula; Ann-Christine Syvänen; A Isoniemi; Leena Peltonen; A Palotie
DNA-based carrier screening in primary healthcare: screening for aspartylglucosaminuria mutations in maternity health offices.
Clinical chemistry 1996;42(9):1398-404.
1996: A Riikonen; Juha Rouvinen; R Tikkanen; Ilkka Julkunen; Leena Peltonen; Anu Jalanko
Primary folding of aspartylglucosaminidase. Significance of disulfide bridges and evidence of early multimerization.
The Journal of biological chemistry 1996;271(35):21340-4.
1996: Satu Kuokkanen; M Sundvall; Joseph D Terwilliger; Pentti J Tienari; Juhani Wikström; R Holmdahl; U Pettersson; Leena Peltonen
A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2.
Nature genetics 1996;13(4):477-80.
1996: T Klockars; M Savukoski; Juha Isosomppi; M Laan; Irma Järvelä; K Petrukhin; Aarno Palotie; Leena Peltonen
Efficient construction of a physical map by fiber-FISH of the CLN5 region: refined assignment and long-range contig covering the critical region on 13q22.
Genomics 1996;35(1):71-8.
1996: R Tikkanen; A Riikonen; Carita Oinonen; R Rouvinen; Leena Peltonen
Functional analyses of active site residues of human lysosomal aspartylglucosaminidase: implications for catalytic mechanism and autocatalytic activation.
The EMBO journal 1996;15(12):2954-60.
1996: S Arte; Pekka Nieminen; Sinikka Pirinen; Irma Thesleff; Leena Peltonen
Gene defect in hypodontia: exclusion of EGF, EGFR, and FGF-3 as candidate genes.
Journal of dental research 1996;75(6):1346-52.
1996: M Peltola; R Tikkanen; Leena Peltonen; Anu Jalanko
Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation.
Human molecular genetics 1996;5(6):737-43.
1996: Päivi Lahermo; Antti Sajantila; Pertti Sistonen; M Lukka; Pertti Aula; Leena Peltonen; Marja-Liisa Savontaus
The genetic relationship between the Finns and the Finnish Saami (Lapps): analysis of nuclear DNA and mtDNA.
American journal of human genetics 1996;58(6):1309-22.
1996: L Karttunen; L Lönnqvist; M Godfrey; Leena Peltonen; Ann-Christine Syvänen
An accurate method for comparing transcript levels of two alleles or highly homologous genes: application to fibrillin transcripts in Marfan patients' fibroblasts.
Genome research 1996;6(5):392-403.
1996: J A Kaukonen; P Amati; Anu Suomalainen; A Rötig; M G Piscaglia; F Salvi; J Weissenbach; G Fratta; G Comi; Leena Peltonen; Massimo Zeviani
An autosomal locus predisposing to multiple deletions of mtDNA on chromosome 3p.
American journal of human genetics 1996;58(4):763-9.
1996: P Nokelainen; Bjarne Udd; Hannu Somer; Leena Peltonen
Linkage analyses in tibial muscular dystrophy.
Human heredity 1996;46(2):98-107.
1996: Teppo Varilo; M Savukoski; R Norio; Pirkko Santavuori; Leena Peltonen; Irma Järvelä
The age of human mutation: genealogical and linkage disequilibrium analysis of the CLN5 mutation in the Finnish population.
American journal of human genetics 1996;58(3):506-12.
1996: R Tikkanen; Juha Rouvinen; A Törrönen; N Kalkkinen; Leena Peltonen
Large-scale purification and preliminary x-ray diffraction studies of human aspartylglucosaminidase.
Proteins 1996;24(2):253-8.
1996: M Henriksson; K Timonen; Pertti Mustajoki; H Pihlaja; R Tenhunen; Leena Peltonen; Raili Kauppinen
Four novel mutations in the ferrochelatase gene among erythropoietic protoporphyria patients.
The Journal of investigative dermatology 1996;106(2):346-50.
1996: Pertti Aula; Marja Hietala; P Niemelä; Arja R Aro; A Hakonen; Leena Peltonen
[Attitudes toward genetic testing in Finland].
Duodecim; lääketieteellinen aikakauskirja 1996;112(2):95-102.
1996: H Mikkola; Vivien C Yee; Martti Syrjälä; R Seitz; R Egbring; P Petrini; Rolf Ljung; Jørgen Ingerslev; David C Teller; Leena Peltonen; Aarno Palotie
Four novel mutations in deficiency of coagulation factor XIII: consequences to expression and structure of the A-subunit.
Blood 1996;87(1):141-51.
1995: Tomi Mäkelä; E Hellsten; Jouni Vesa; H Hirvonen; Aarno Palotie; Leena Peltonen; Kari Alitalo
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein.
Oncogene 1995;11(12):2699-704.
1995: Leena Peltonen; P Pekkarinen; Jaakko Aaltonen
Messages from an isolate: lessons from the Finnish gene pool.
Biological chemistry Hoppe-Seyler 1995;376(12):697-704.
1995: Carita Oinonen; R Tikkanen; Juha Rouvinen; Leena Peltonen
Three-dimensional structure of human lysosomal aspartylglucosaminidase.
Nature structural biology 1995;2(12):1102-8.
1995: T Rantamäki; Michael Raghunath; L Karttunen; L Lönnqvist; A Child; Leena Peltonen
Prenatal diagnosis of Marfan syndrome: identification of a fibrillin-1 mutation in chorionic villus sample.
Prenatal diagnosis 1995;15(12):1176-81.
1995: Minna Männikkö; M Kestailä; Christer Holmberg; R Norio; M Ryynänen; A Olsen; Leena Peltonen; Karl Tryggvason
Fine mapping and haplotype analysis of the locus for congenital nephrotic syndrome on chromosome 19q13.1.
American journal of human genetics 1995;57(6):1377-83.
1995: K Tenhunen; M Laan; T Manninen; Aarno Palotie; Leena Peltonen; Anu Jalanko
Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene.
Genomics 1995;30(2):244-50.
1995: M Heiskanen; E Hellsten; Olli Kallioniemi; Tomi Mäkelä; Kari Alitalo; Leena Peltonen; Aarno Palotie
Visual mapping by fiber-FISH.
Genomics 1995;30(1):31-6.
1995: J Schleutker; P Leppänen; J E Månsson; A Erikson; J Weissenbach; Leena Peltonen; Pertti Aula
Lysosomal free sialic acid storage disorders with different phenotypic presentations--infantile-form sialic acid storage disease and Salla disease--represent allelic disorders on 6q14-15.
American journal of human genetics 1995;57(4):893-901.
1995: P Paavola; Riitta Salonen; J Weissenbach; Leena Peltonen
The locus for Meckel syndrome with multiple congenital anomalies maps to chromosome 17q21-q24.
Nature genetics 1995;11(2):213-5.
1995: P Pekkarinen; Joseph D Terwilliger; Per-Erik Harry Bredbacka; Jouko Lönnqvist; Leena Peltonen
Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.
Genome research 1995;5(2):105-15.
1995: Pekka Nieminen; S Arte; Sinikka Pirinen; Leena Peltonen; Irma Thesleff
Gene defect in hypodontia: exclusion of MSX1 and MSX2 as candidate genes.
Human genetics 1995;96(3):305-8.
1995: M Laan; K Grön-Virta; A Salo; Pertti Aula; Leena Peltonen; Aarno Palotie; Ann-Christine Syvänen
Solid-phase minisequencing confirmed by FISH analysis in determination of gene copy number.
Human genetics 1995;96(3):275-80.
1995: M Laan; Olli Kallioniemi; E Hellsten; Kari Alitalo; Leena Peltonen; Aarno Palotie
Mechanically stretched chromosomes as targets for high-resolution FISH mapping.
Genome research 1995;5(1):13-20.
1995: Markku Sainio; T Strachan; G Blomstedt; Oili Salonen; Kirsi Setälä; A Palotie; Jukka U Palo; Ilmari Pyykkö; Leena Peltonen; Juha Jääskeläinen
Presymptomatic DNA and MRI diagnosis of neurofibromatosis 2 with mild clinical course in an extended pedigree.
Neurology 1995;45(7):1314-22.
1995: J Sharp; M Savukoski; Ruth B Wheeler; J Harris; Irma Järvelä; Leena Peltonen; M Gardiner; Roger Williams
Linkage analysis of late-infantile neuronal ceroid-lipofuscinosis.
American journal of medical genetics 1995;57(2):348-9.
1995: Marja Hietala; A Hakonen; Arja R Aro; P Niemelä; Leena Peltonen; Pertti Aula
Attitudes toward genetic testing among the general population and relatives of patients with a severe genetic disease: a survey from Finland.
American journal of human genetics 1995;56(6):1493-500.
1995: N Enomaa; O Danos; Leena Peltonen; Anu Jalanko
Correction of deficient enzyme activity in a lysosomal storage disease, aspartylglucosaminuria, by enzyme replacement and retroviral gene transfer.
Human gene therapy 1995;6(6):723-31.
1995: J Schleutker; A P Laine; L Haataja; M Renlund; J Weissenbach; Pertti Aula; Leena Peltonen
Linkage disequilibrium utilized to establish a refined genetic position of the Salla disease locus on 6q14-q15.
Genomics 1995;27(2):286-92.
1995: Kaisu Nikali; Anu Suomalainen; Joseph D Terwilliger; T Koskinen; J Weissenbach; Leena Peltonen
Random search for shared chromosomal regions in four affected individuals: the assignment of a new hereditary ataxia locus.
American journal of human genetics 1995;56(5):1088-95.
1995: R Tikkanen; N Enomaa; A Riikonen; E Ikonen; Leena Peltonen
Intracellular sorting of aspartylglucosaminidase: the role of N-linked oligosaccharides and evidence of Man-6-P-independent lysosomal targeting.
DNA and cell biology 1995;14(4):305-12.
1995: A Riikonen; R Tikkanen; Anu Jalanko; Leena Peltonen
Immediate interaction between the nascent subunits and two conserved amino acids Trp34 and Thr206 are needed for the catalytic activity of aspartylglucosaminidase.
The Journal of biological chemistry 1995;270(9):4903-7.
1995: Anu Jalanko; T Manninen; Leena Peltonen
Deletion of the C-terminal end of aspartylglucosaminidase resulting in a lysosomal accumulation disease: evidence for a unique genomic rearrangement.
Human molecular genetics 1995;4(3):435-41.
1995: Cay M Kielty; T Rantamäki; A H Child; C Adrian Shuttleworth; Leena Peltonen
Cysteine-to-arginine point mutation in a 'hybrid' eight-cysteine domain of FBN1: consequences for fibrillin aggregation and microfibril assembly.
Journal of cell science 1995;108 ( Pt 3)():1317-23.
1995: Raili Kauppinen; Sami Mustajoki; H Pihlaja; Leena Peltonen; Pertti Mustajoki
Acute intermittent porphyria in Finland: 19 mutations in the porphobilinogen deaminase gene.
Human molecular genetics 1995;4(2):215-22.
1995: Elisabeth W Almqvist; N Spence; K Nichol; S E Andrew; J Vesa; Leena Peltonen; Maria Anvret; J Goto; I Kanazawa; Y Paul Goldberg
Ancestral differences in the distribution of the delta 2642 glutamic acid polymorphism is associated with varying CAG repeat lengths on normal chromosomes: insights into the genetic evolution of Huntington disease.
Human molecular genetics 1995;4(2):207-14.
1995: Anu Suomalainen; J Kaukonen; P Amati; R Timonen; M Haltia; J Weissenbach; Massimo Zeviani; H Somer; Leena Peltonen
An autosomal locus predisposing to deletions of mitochondrial DNA.
Nature genetics 1995;9(2):146-51.
1995: E Hellsten; Jouni Vesa; M Heiskanen; Tomi Mäkelä; Irma Järvelä; John Kenneth Cowell; S Mead; Kari Alitalo; Aarno Palotie; Leena Peltonen
Identification of YAC clones for human chromosome 1p32 and physical mapping of the infantile neuronal ceroid lipofuscinosis (INCL) locus.
Genomics 1995;25(2):404-12.
1995: Julie D Sharp; Ruth B Wheeler; M Savukoski; M Kestila; Irma Järvelä; Leena Peltonen; H Eiberg; R Mark Gardiner; Roger Williams
Exclusion mapping of classical late infantile neuronal ceroid lipofuscinosis (Jansky-Bielschowsky disease, CLN2)
European journal of human genetics : EJHG 1995;3(5):326-8.
1995: Katri Vuopala; P Mäkelä-Bengs; Anu Suomalainen; Riitta Herva; Jaakko Leisti; Leena Peltonen
Lethal congenital contracture syndrome (LCCS), a fetal anterior horn cell disease, is not linked to the SMA 5q locus.
Journal of medical genetics 1995;32(1):36-8.
1995: A Isoniemi; Marja Hietala; Pertti Aula; Anu Jalanko; Leena Peltonen
Identification of a novel mutation causing aspartylglucosaminuria reveals a mutation hotspot region in the aspartylglucosaminidase gene.
Human mutation 1995;5(4):318-26.
1995: Tiina Paunio; Y Sunada; S Kiuru; H Makishita; S Ikeda; J Weissenbach; Jukka U Palo; Leena Peltonen
Haplotype analysis in gelsolin-related amyloidosis reveals independent origin of identical mutation (G654A) of gelsolin in Finland and Japan.
Human mutation 1995;6(1):60-5.
1994: L Karttunen; Michael Raghunath; L Lönnqvist; Leena Peltonen
A compound-heterozygous Marfan patient: two defective fibrillin alleles result in a lethal phenotype.
American journal of human genetics 1994;55(6):1083-91.
1994: M Peltola; D Chiatayat; Leena Peltonen; Anu Jalanko
Characterization of a point mutation in aspartylglucosaminidase gene: evidence for a readthrough of a translational stop codon.
Human molecular genetics 1994;3(12):2237-42.
1994: Tiina Paunio; Hannele Kangas; N Kalkkinen; M Haltia; Jukka U Palo; Leena Peltonen
Toward understanding the pathogenic mechanisms in gelsolin-related amyloidosis: in vitro expression reveals an abnormal gelsolin fragment.
Human molecular genetics 1994;3(12):2223-9.
1994: Kaisu Nikali; T Koskinen; Anu Suomalainen; Helena Pihko; Leena Peltonen
Infantile onset spinocerebellar ataxia represents an allelic disease distinct from other hereditary ataxias.
Pediatric research 1994;36(5):607-12.
1994: M Heiskanen; Ritva Karhu; E Hellsten; Leena Peltonen; Olli Kallioniemi; Aarno Palotie
High resolution mapping using fluorescence in situ hybridization to extended DNA fibers prepared from agarose-embedded cells.
BioTechniques 1994;17(5):928-9, 932-3.
1994: M Savukoski; M Kestilä; Roger Williams; Irma Järvelä; J Sharp; J Harris; Pirkko Santavuori; M Gardiner; Leena Peltonen
Defined chromosomal assignment of CLN5 demonstrates that at least four genetic loci are involved in the pathogenesis of human ceroid lipofuscinoses.
American journal of human genetics 1994;55(4):695-701.
1994: Iiris Hovatta; Mikko Kallela; M Färkkilä; Leena Peltonen
Familial migraine: exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p.
Genomics 1994;23(3):707-9.
1994: Antti Sajantila; P Pacek; M Lukka; Ann-Christine Syvänen; P Nokelainen; Pertti Sistonen; Leena Peltonen; B Budowle
A microsatellite polymorphism in the von Willebrand factor gene: comparison of allele frequencies in different population samples and evaluation for forensic medicine.
Forensic science international 1994;68(2):91-102.
1994: Michael Raghunath; Cay M Kielty; K Kainulainen; A Child; Leena Peltonen; Beat Steinmann
Analyses of truncated fibrillin caused by a 366 bp deletion in the FBN1 gene resulting in Marfan syndrome.
The Biochemical journal 1994;302 ( Pt 3)():889-96.
1994: Jaakko Aaltonen; P Björses; L Sandkuijl; J Perheentupa; Leena Peltonen
An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21.
Nature genetics 1994;8(1):83-7.
1994: H Mikkola; Martti Syrjälä; Vesa Rasi; Elina Vahtera; Eija Hämäläinen; Leena Peltonen; Aarno Palotie
Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels.
Blood 1994;84(2):517-25.
1994: L Haataja; J Schleutker; A P Laine; M Renlund; Marja-Liisa Savontaus; C Dib; J Weissenbach; Leena Peltonen; Pertti Aula
The genetic locus for free sialic acid storage disease maps to the long arm of chromosome 6.
American journal of human genetics 1994;54(6):1042-9.
1994: O K Tollersrud; T Heiskanen; Leena Peltonen
Human leucocyte glycosylasparaginase is an alpha/beta-heterodimer of 19 kDa alpha-subunit and 17 and 18 kDa beta-subunit.
The Biochemical journal 1994;300 ( Pt 2)():541-4.
1994: Marjo Kestilä; Minna Männikkö; Christer Holmberg; G Gyapay; Jean Weissenbach; E R Savolainen; Leena Peltonen; Karl Tryggvason
Congenital nephrotic syndrome of the Finnish type maps to the long arm of chromosome 19.
American journal of human genetics 1994;54(5):757-64.
1994: T Heiskanen; O K Tollersrud; M Zhao; Leena Peltonen
Large-scale purification of human aspartylglucosaminidase: utilization of exceptional sodium dodecyl sulfate resistance.
Protein expression and purification 1994;5(2):205-10.
1994: Marjo Kestilä; Minna Männikkö; Christer Holmberg; K Korpela; E R Savolainen; Leena Peltonen; Karl Tryggvason
Exclusion of eight genes as mutated loci in congenital nephrotic syndrome of the Finnish type.
Kidney international 1994;45(4):986-90.
1994: Roger Williams; Pirkko Santavuori; Leena Peltonen; R Mark Gardiner; Irma Järvelä
A variant form of late infantile neuronal ceroid lipofuscinosis (CLN5) is not an allelic form of Batten (Spielmeyer-Vogt-Sjögren, CLN3) disease: exclusion of linkage to the CLN3 region of chromosome 16.
Genomics 1994;20(2):289-90.
1994: A Riikonen; E Ikonen; R Sormunen; V P Lehto; Leena Peltonen; Anu Jalanko
Dissection of the molecular consequences of a double mutation causing a human lysosomal disease.
DNA and cell biology 1994;13(3):257-64.
1994: L Lönnqvist; A Child; K Kainulainen; R Davidson; L Puhakka; Leena Peltonen
A novel mutation of the fibrillin gene causing ectopia lentis.
Genomics 1994;19(3):573-6.
1994: Marjo Kestilä; Minna Männikkö; Christer Holmberg; Karl Tryggvason; Leena Peltonen
Congenital nephrotic syndrome of the Finnish type is not associated with the Pax-2 gene despite the promising transgenic animal model.
Genomics 1994;19(3):570-2.
1994: N Carey; keith jack johnson; P Nokelainen; Leena Peltonen; Marja-Liisa Savontaus; Vesa Juvonen; M Anvret; U Grandell; K Chotai; E Robertson
Meiotic drive at the myotonic dystrophy locus?
Nature genetics 1994;6(2):117-8.
1994: Jouni Vesa; E Hellsten; B L Barnoski; B S Emanuel; J T Billheimer; S Mead; John Kenneth Cowell; Jerome F Strauss; Leena Peltonen
Assignment of sterol carrier protein X/sterol carrier protein 2 to 1p32 and its exclusion as the causative gene for infantile neuronal ceroid lipofuscinosis.
Human molecular genetics 1994;3(2):341-6.
1994: Pentti J Tienari; Joseph D Terwilliger; J Ott; Jukka U Palo; Leena Peltonen
Two-locus linkage analysis in multiple sclerosis (MS).
Genomics 1994;19(2):320-5.
1994: K Kainulainen; L Karttunen; L Puhakka; L Sakai; Leena Peltonen
Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome.
Nature genetics 1994;6(1):64-9.
1994: T Rantamäki; L Lönnqvist; L Karttunen; K Kainulainen; Leena Peltonen
DNA diagnostics of the Marfan syndrome: application of amplifiable polymorphic markers.
European journal of human genetics : EJHG 1994;2(1):66-75.
1994: Iiris Hovatta; J Seppälä; P Pekkarinen; A Tanskanen; Jouko Lönnqvist; Leena Peltonen
Linkage analysis in two schizophrenic families originating from a restricted subpopulation of Finland.
Psychiatric genetics 1994;4(3):143-52.
1993: Miikka Vikkula; Martti Nissilä; E Hirvensalo; P Nuotio; A Palotie; K Aho; Leena Peltonen
Multiallelic polymorphism of the cartilage collagen gene: no association with osteoarthrosis.
Annals of the rheumatic diseases 1993;52(10):762-4.
1993: R Halila; E Ikonen; O Tollersrud; Ann-Christine Syvänen; N Enomaa; Leena Peltonen
Aspartylglucosaminuria (AGU): protein and gene structure of normal and mutated aspartylglucosaminidase.
Biochemical medicine and metabolic biology 1993;50(1):1-8.
1993: N E Enomaa; P L Lukinmaa; E M Ikonen; J C Waltimo; Aarno Palotie; A E Paetau; Leena Peltonen
Expression of aspartylglucosaminidase in human tissues from normal individuals and aspartylglucosaminuria patients.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993;41(7):981-9.
1993: E Hellsten; Jouni Vesa; M C Speer; Tomi Mäkelä; Irma Järvelä; Kari Alitalo; J Ott; Leena Peltonen
Refined assignment of the infantile neuronal ceroid lipofuscinosis (INCL, CLN1) locus at 1p32: incorporation of linkage disequilibrium in multipoint analysis.
Genomics 1993;16(3):720-5.
1993: Anu Suomalainen; A Majander; Helena Pihko; Leena Peltonen; Ann-Christine Syvänen
Quantification of tRNA3243(Leu) point mutation of mitochondrial DNA in MELAS patients and its effects on mitochondrial transcription.
Human molecular genetics 1993;2(5):525-34.
1993: Miikka Vikkula; P Ritvaniemi; Alpo Vuorio; Ilkka Kaitila; Leena Ala-Kokko; Leena Peltonen
A mutation in the amino-terminal end of the triple helix of type II collagen causing severe osteochondrodysplasia.
Genomics 1993;16(1):282-5.
1993: P Nokelainen; P Shelbourne; D Shaw; J David Brook; H G Harley; keith jack johnson; Hannu Somer; Marja-Liisa Savontaus; Leena Peltonen
The DM mutation; diagnostic applications in the Finnish population.
Clinical genetics 1993;43(4):190-5.
1993: Miikka Vikkula; A Palotie; P Ritvaniemi; J Ott; Leena Ala-Kokko; U Sievers; K Aho; Leena Peltonen
Early-onset osteoarthritis linked to the type II procollagen gene. Detailed clinical phenotype and further analyses of the gene.
Arthritis and rheumatism 1993;36(3):401-9.
1993: E Ikonen; Ilkka Julkunen; O K Tollersrud; N Kalkkinen; Leena Peltonen
Lysosomal aspartylglucosaminidase is processed to the active subunit complex in the endoplasmic reticulum.
The EMBO journal 1993;12(1):295-302.
1993: E Hellsten; Jouni Vesa; Irma Järvelä; Tomi Mäkelä; Pirkko Santavuori; Leena Peltonen
Refined assignment of the infantile neuronal ceroid-lipofuscinosis (INCL) locus at 1p32 and the current status of prenatal and carrier diagnostics.
Journal of inherited metabolic disease 1993;16(2):335-8.
1993: E Ikonen; Ann-Christine Syvänen; Leena Peltonen
Dissection of the molecular pathology of aspartylglucosaminuria provides the basis for DNA diagnostics and future therapeutic interventions.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1993;213():19-27.
1993: Marja Hietala; K Grön; Ann-Christine Syvänen; Leena Peltonen; Pertti Aula
Prospects of carrier screening of aspartylglucosaminuria in Finland.
European journal of human genetics : EJHG 1993;1(4):296-300.
1993: Pentti J Tienari; Juhani Wikström; S Koskimies; J Partanen; Jukka U Palo; Leena Peltonen
Reappraisal of HLA in multiple sclerosis: close linkage in multiplex families.
European journal of human genetics : EJHG 1993;1(4):257-68.
1993: Jaakko Aaltonen; J Komulainen; A Vikman; Aarno Palotie; C Wadelius; J Perheentupa; Leena Peltonen
Autoimmune polyglandular disease type I. Exclusion map using amplifiable multiallelic markers in a microtiter well format.
European journal of human genetics : EJHG 1993;1(2):164-71.
1993: Jouni Vesa; E Hellsten; Tomi Mäkelä; Irma Järvelä; T Airaksinen; Pirkko Santavuori; Leena Peltonen
A single PCR marker in strong allelic association with the infantile form of neuronal ceroid lipofuscinosis facilitates reliable prenatal diagnostics and disease carrier identification.
European journal of human genetics : EJHG 1993;1(2):125-32.
1992: Irma Järvelä; Jouni Vesa; Pirkko Santavuori; E Hellsten; Leena Peltonen
Molecular genetics of neuronal ceroid lipofuscinoses.
Pediatric research 1992;32(6):645-8.
1992: Anu Suomalainen; A Paetau; H Leinonen; A Majander; Leena Peltonen; Hannu Somer
Inherited idiopathic dilated cardiomyopathy with multiple deletions of mitochondrial DNA.
Lancet 1992;340(8831):1319-20.
1992: Pentti J Tienari; Juhani Wikström; Antti Sajantila; Jukka U Palo; Leena Peltonen
Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene.
Lancet 1992;340(8826):987-91.
1992: N Enomaa; T Heiskanen; R Halila; Raija Sormunen; R Seppälä; Mauno Vihinen; Leena Peltonen
Human aspartylglucosaminidase. A biochemical and immunocytochemical characterization of the enzyme in normal and aspartylglucosaminuria fibroblasts.
The Biochemical journal 1992;286 ( Pt 2)():613-8.
1992: Leena Peltonen; K Kainulainen
Elucidation of the gene defect in Marfan syndrome. Success by two complementary research strategies.
FEBS letters 1992;307(1):116-21.
1992: Miikka Vikkula; M Metsäranta; A C Syvänen; Leena Ala-Kokko; E Vuorio; Leena Peltonen
Structural analysis of the regulatory elements of the type-II procollagen gene. Conservation of promoter and first intron sequences between human and mouse.
The Biochemical journal 1992;285 ( Pt 1)():287-94.
1992: Anu Suomalainen; A Majander; M Haltia; Hannu Somer; J Lönnqvist; Marja-Liisa Savontaus; Leena Peltonen
Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia.
The Journal of clinical investigation 1992;90(1):61-6.
1992: K Kainulainen; L Y Sakai; A Child; F Michael Pope; L Puhakka; L Ryhänen; Aarno Palotie; Ilkka Kaitila; Leena Peltonen
Two mutations in Marfan syndrome resulting in truncated fibrillin polypeptides.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5917-21.
1992: E Ikonen; A Salo; Mirja Somer; Hannu Somer; L Pääkkönen; Leena Peltonen
Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.
American journal of medical genetics 1992;43(4):753-8.
1992: Leena Peltonen; E Ikonen; Tiina Paunio
Applications of PCR in the diseases of genetic isolates.
Annals of medicine 1992;24(3):191-4.
1992: Tomi Mäkelä; E Hellsten; Jouni Vesa; Kari Alitalo; Leena Peltonen
An Alu variable polyA repeat polymorphism upstream of L-myc at 1p32.
Human molecular genetics 1992;1(3):217.
1992: E Ikonen; I Ulmanen; Leena Peltonen
Deletion of the 3'-untranslated region of aspartylglucosaminidase mRNA results in a lysosomal accumulation disease.
The Journal of biological chemistry 1992;267(13):8715-8.
1992: E Ikonen; T Manninen; Leena Peltonen; Ann-Christine Syvänen
Quantitative determination of rare mRNA species by PCR and solid-phase minisequencing.
PCR methods and applications 1992;1(4):234-40.
1992: E Ikonen; Jaakko Ignatius; R Norio; Jukka U Palo; Leena Peltonen
Huntington disease in Finland: a molecular and genealogical study.
Human genetics 1992;89(3):275-80.
1992: Tiina Paunio; S Kiuru; V Hongell; E Mustonen; Ann-Christine Syvänen; M Bengström; Jukka U Palo; Leena Peltonen
Solid-phase minisequencing test reveals Asp187----Asn (G654----A) mutation of gelsolin in all affected individuals with Finnish type of familial amyloidosis.
Genomics 1992;13(1):237-9.
1992: Harriet von Koskull; A M Nordström; Riitta Salonen; Leena Peltonen
Prenatal diagnosis and carrier detection in fragile X.
American journal of medical genetics 1992;43(1-2):174-80.
1992: Antti Sajantila; B Budowle; M Ström; V Johnsson; M Lukka; Leena Peltonen; Christian Ehnholm
PCR amplification of alleles at the DIS80 locus: comparison of a Finnish and a North American Caucasian population sample, and forensic casework evaluation.
American journal of human genetics 1992;50(4):816-25.
1992: Ann-Christine Syvänen; E Ikonen; T Manninen; M Bengtström; Hans Söderlund; Pertti Aula; Leena Peltonen
Convenient and quantitative determination of the frequency of a mutant allele using solid-phase minisequencing: application to aspartylglucosaminuria in Finland.
Genomics 1992;12(3):590-5.
1992: P J Tienari; E Tuomilehto-Wolf; J Tuomilehto; Leena Peltonen
HLA haplotypes in type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus. The DIME Study Group.
Diabetologia 1992;35(3):254-60.
1992: Irma Järvelä; P Santavuori; L Puhakka; M Haltia; Leena Peltonen
Linkage map of the chromosomal region surrounding the infantile neuronal ceroid lipofuscinosis on 1p.
American journal of medical genetics 1992;42(4):546-8.
1992: P Helminen; Antti Sajantila; V Johnsson; M Lukka; Christian Ehnholm; Leena Peltonen
Amplification of three hypervariable DNA regions by polymerase chain reaction for paternity determinations: comparison with conventional methods and DNA fingerprinting.
Molecular and cellular probes 1992;6(1):21-6.
1992: L Haataja; J Schleutker; M Renlund; Aarno Palotie; Leena Peltonen; Pertti Aula
Exclusion map of Salla disease: attempts to localize the disease gene using a computer program.
Human genetics 1992;88(3):298-300.
1992: Antti Sajantila; K Makkonen; Christian Ehnholm; Leena Peltonen
DNA profiling in a genetically isolated population using three hypervariable DNA markers.
Human heredity 1992;42(6):372-9.
1992: Raili Kauppinen; Leena Peltonen; H Pihlaja; Pertti Mustajoki
CRIM-positive mutations of acute intermittent porphyria in Finland.
Human mutation 1992;1(5):392-6.
1992: E Ikonen; Leena Peltonen
Mutations causing aspartylglucosaminuria (AGU): a lysosomal accumulation disease.
Human mutation 1992;1(5):361-5.
1991: E Ikonen; Pertti Aula; K Grön; O Tollersrud; R Halila; T Manninen; Ann-Christine Syvänen; Leena Peltonen
Spectrum of mutations in aspartylglucosaminuria.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11222-6.
1991: J Schleutker; L Haataja; M Renlund; L Puhakka; J Viitala; Leena Peltonen; Pertti Aula
Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease.
Human genetics 1991;88(1):95-7.
1991: Juhani Rapola; Irma Järvelä; Leena Peltonen
The neuronal ceroid lipofuscinoses: unfolding the genetic defect.
Pediatric pathology / affiliated with the International Paediatric Pathology Association 1991;11(6):799-806.
1991: P Helminen; V Johnsson; Christian Ehnholm; Leena Peltonen
Proving paternity of children with deceased fathers.
Human genetics 1991;87(6):657-60.
1991: K Kainulainen; Leena Peltonen
Marfan gene discovered.
Annals of medicine 1991;23(4):395-6.
1991: Antti Sajantila; M Ström; B Budowle; P J Karhunen; Leena Peltonen
The polymerase chain reaction and post-mortem forensic identity testing: application of amplified D1S80 and HLA-DQ alpha loci to the identification of fire victims.
Forensic science international 1991;51(1):23-34.
1991: E Ikonen; N Enomaa; I Ulmanen; Leena Peltonen
In vitro mutagenesis helps to unravel the biological consequences of aspartylglucosaminuria mutation.
Genomics 1991;11(1):206-11.
1991: T Hiltunen; S Kiuru; V Hongell; Tiina Heliö; Jukka U Palo; Leena Peltonen
Finnish type of familial amyloidosis: cosegregation of Asp187----Asn mutation of gelsolin with the disease in three large families.
American journal of human genetics 1991;49(3):522-8.
1991: H Tenkanen; M Lukka; Matti Jauhiainen; Jari Metso; M Baumann; Leena Peltonen; Christian Ehnholm
The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):851-6.
1991: T Malinen; Aarno Palotie; Seppo Pakkala; Leena Peltonen; Tapani Ruutu; Sten-Erik Jansson
Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation.
Blood 1991;77(11):2435-40.
1991: R Halila; M Baumann; E Ikonen; N Enomaa; Leena Peltonen
Human leucocyte aspartylglucosaminidase. Evidence for two different subunits in a more complex native structure.
The Biochemical journal 1991;276 ( Pt 1)():251-6.
1991: Irma Järvelä; J Rapola; Leena Peltonen; L Puhakka; Jouni Vesa; P Ammälä; R Salonen; Markku Ryynänen; P Haring; A Mustonen
DNA-based prenatal diagnosis of the infantile form of neuronal ceroid lipofuscinosis (INCL, CLN1).
Prenatal diagnosis 1991;11(5):323-8.
1991: P T Nokelainen; L Alanen-Kurki; Hannu Somer; S H Pihko; Leena Peltonen
Usefulness of chromosome 19 RFLP haplotypes in the diagnosis of myotonic dystrophy.
Muscle & nerve 1991;14(5):451-6.
1991: Antti Sajantila; M Ström; B Budowle; Pentti J Tienari; Christian Ehnholm; Leena Peltonen
The distribution of the HLA-DQ alpha alleles and genotypes in the Finnish population as determined by the use of DNA amplification and allele specific oligonucleotides.
International journal of legal medicine 1991;104(4):181-4.
1991: E Ikonen; M Baumann; K Grön; Ann-Christine Syvänen; N Enomaa; R Halila; Pertti Aula; Leena Peltonen
Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase and the missense mutation causing the disease.
The EMBO journal 1991;10(1):51-8.
1990: Seppo Pakkala; Sakari Knuutila; P Helminen; Tapani Ruutu; UM Saarinen; Leena Peltonen
DNA-fingerprint changes compared to karyotypes in acute leukemia.
Leukemia 1990;4(12):866-70.
1990: K Kainulainen; L Pulkkinen; A Savolainen; Ilkka Kaitila; Leena Peltonen
Location on chromosome 15 of the gene defect causing Marfan syndrome.
The New England journal of medicine 1990;323(14):935-9.
1990: I Jokiaho; L Puhakka; P Santavuori; T Manninen; K Nyman; Leena Peltonen
Infantile neuronal ceroid-lipofuscinosis is not an allelic form of Batten disease: exclusion of chromosome 16 region with linkage analyses.
Genomics 1990;8(2):391-3.
1990: P Nokelainen; L Alanen-Kurki; Robert Winqvist; B Falck; Hannu Somer; Jaakko Leisti; keith jack johnson; Marja-Liisa Savontaus; Leena Peltonen
Linkage disequilibrium detected between dystrophia myotonica and APOC2 locus in the Finnish population.
Human genetics 1990;85(5):541-5.
1990: K Grön; Pertti Aula; Leena Peltonen
Linkage of aspartylglucosaminuria (AGU) to marker loci on the long arm of chromosome 4.
Human genetics 1990;85(2):233-6.
1990: Raili Kauppinen; Leena Peltonen; A Palotie; Pertti Mustajoki
RFLP analysis of three different types of acute intermittent porphyria.
Human genetics 1990;85(2):160-4.
1990: K Kainulainen; J Rosenbloom; Leena Peltonen
Two polymorphisms for the human elastin gene.
Nucleic acids research 1990;18(10):3114.
1990: S Blanton; M Sarfarazi; H Eiberg; J de Groote; P A Farndon; Michael W Kilpatrick; A H Child; F Michael Pope; Leena Peltonen; Clair A Francomano
An exclusion map of Marfan syndrome.
Journal of medical genetics 1990;27(2):73-7.
1990: K Kainulainen; A Savolainen; Aarno Palotie; Ilkka Kaitila; J Rosenbloom; Leena Peltonen
Marfan syndrome: exclusion of genetic linkage to five genes coding for connective tissue components in the long arm of chromosome 2.
Human genetics 1990;84(3):233-6.
1990: Leena Peltonen
New views to the molecular pathology of osteoarthrosis.
Annals of medicine 1990;22(4):219-20.
1990: E Ikonen; Jukka U Palo; J Ott; James Gusella; Hannu Somer; L Karila; Aarno Palotie; Leena Peltonen
Huntington disease in Finland: linkage disequilibrium of chromosome 4 RFLP haplotypes and exclusion of a tight linkage between the disease and D4S43 locus.
American journal of human genetics 1990;46(1):5-11.
1989: M Baumann; Leena Peltonen; Pertti Aula; Nisse Kalkkinen
Isolation of a human hepatic 60 kDa aspartylglucosaminidase consisting of three non-identical polypeptides.
The Biochemical journal 1989;262(1):189-94.
1989: M Vikkula; Leena Peltonen
Structural analyses of the polymorphic area in type II collagen gene.
FEBS letters 1989;250(2):171-4.
1989: K Elima; I Kaitila; L Mikonoja; U Elonsalo; Leena Peltonen; Eero Vuorio
Exclusion of the COL2A1 gene as the mutation site in diastrophic dysplasia.
Journal of medical genetics 1989;26(5):314-9.
1989: A Palotie; P Väisänen; J Ott; L Ryhänen; K Elima; M Vikkula; K Cheah; E Vuorio; Leena Peltonen
Predisposition to familial osteoarthrosis linked to type II collagen gene.
Lancet 1989;1(8644):924-7.
1989: Seppo Pakkala; P Helminen; Tapani Ruutu; UM Saarinen; Leena Peltonen
New molecular marker in AML: DNA-fingerprint differences between leukemic phase and remission in acute myeloid leukemia.
Leukemia research 1989;13(10):907-13.
1988: Hannu Somer; A Palotie; Mirja Somer; V Hoikka; Leena Peltonen
Osteoporosis-pseudoglioma syndrome: clinical, morphological, and biochemical studies.
Journal of medical genetics 1988;25(8):543-9.
1988: P Helminen; Christian Ehnholm; M L Lokki; A Jeffreys; Leena Peltonen
Application of DNA "fingerprints" to paternity determinations.
Lancet 1988;1(8585):574-6.
1988: Seppo Pakkala; P Helminen; UM Saarinen; Riitta Alitalo; Leena Peltonen
Differences in DNA-fingerprints between remission and relapse in childhood acute lymphoblastic leukemia.
Leukemia research 1988;12(9):757-62.
1987: Jukka U Palo; Hannu Somer; E Ikonen; L Karila; Leena Peltonen
Low prevalence of Huntington's disease in Finland.
Lancet 1987;2(8562):805-6.
1987: N Gahmberg; Leena Peltonen
Efficient export of secretory proteins through a vacuolized Golgi complex.
Cell biology international reports 1987;11(7):547-55.
1985: Helena Kuivaniemi; Leena Peltonen; Kari I Kivirikko
Type IX Ehlers-Danlos syndrome and Menkes syndrome: the decrease in lysyl oxidase activity is associated with a corresponding deficiency in the enzyme protein.
American journal of human genetics 1985;37(4):798-808.