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Trevor Penning

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Oleg A Barski; Rebekka Mindnich; Trevor M Penning
Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature.
Sushmita Sen; Pratik Bhojnagarwala; Lauren Francey; Ding Lu; Trevor M Penning; Jeffrey Field
p53 Mutagenesis by benzo[a]pyrene derived radical cations.
Maša Sinreih; Izidor Sosič; Samo Turk; Adegoke O Adeniji; Nataša Beranič; Trevor M Penning; Tea Lanišnik Rižner; Stanislav Gobec
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.

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All Publications

2013: Oleg A Barski; Rebekka Mindnich; Trevor M Penning
Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature.
Chemico-biological interactions 2013;202(1-3):153-8.
2012: Sushmita Sen; Pratik Bhojnagarwala; Lauren Francey; Ding Lu; Trevor M Penning; Jeffrey Field
p53 Mutagenesis by benzo[a]pyrene derived radical cations.
Chemical research in toxicology 2012;25(10):2117-26.
2012: Maša Sinreih; Izidor Sosič; Samo Turk; Adegoke O Adeniji; Nataša Beranič; Trevor M Penning; Tea Lanišnik Rižner; Stanislav Gobec
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.
Bioorganic & medicinal chemistry letters 2012;22(18):5948-51.
2012: Petra Brožič; Adegoke O Adeniji; Dušanka Janežič; Janez Konc; Tea Lanišnik Rižner; Trevor M Penning; Samo Turk; Stanislav Gobec
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.
Journal of medicinal chemistry 2012;55(17):7417-24.
2012: Li Zhang; Ian A Blair; Meng Huang; Trevor M Penning
Detoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cells.
The Journal of biological chemistry 2012;287(35):29909-20.
2012: Meng Huang; Mary E Kushman; Xiaojing Liu; Sankha S Basu; Ian A Blair; Ronald G Harvey; Li Zhang; Trevor M Penning
Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct.
Chemical research in toxicology 2012;25(5):993-1003.
2012: Mo Chen; David W Christianson; Barry M Twenter; Jeffrey D Winkler; Adegoke O Adeniji; Trevor M Penning
Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.
Bioorganic & medicinal chemistry letters 2012;22(10):3492-7.
2012: Michael C Byrns; Ling Duan; Rebekka Mindnich; Trevor M Penning
Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride.
The Journal of steroid biochemistry and molecular biology 2012;130(1-2):7-15.
2012: Yi Jin; Mo Chen; Ling Duan; Trevor M Penning; Helenius J Kloosterboer
Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily.
The Journal of steroid biochemistry and molecular biology 2012;129(3-5):139-44.
2012: Lianli Sun; Meitian Wang; Yixin Chen; Rebekka Mindnich; Uwe Mueller; Santosh Panjikar; Trevor M Penning; Chitra Rajendran; Cindy Rosenthal; Joachim Stöckigt
Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
The Journal of biological chemistry 2012;287(14):11213-21.
2012: Adegoke O Adeniji; Michael C Byrns; Mo Chen; Yi Jin; Barry M Twenter; Jeffrey D Winkler; Trevor M Penning
Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.
Journal of medicinal chemistry 2012;55(5):2311-23.
2012: Li Zhang; Meng Huang; Yi Jin; Trevor M Penning
The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones.
Frontiers in pharmacology 2012;3():193.
2011: Ding Lu; Ian A Blair; Ronald G Harvey; Trevor M Penning
Quantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
Chemical research in toxicology 2011;24(11):1905-14.
2011: Li Zhang; Ian A Blair; Mo Chen; Ronald G Harvey; Meng Huang; Yi Jin; Trevor M Penning
Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols.
The Journal of biological chemistry 2011;286(29):25644-54.
2011: Yi Jin; A Clementina Mesaros; Ian A Blair; Trevor M Penning
Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.
The Biochemical journal 2011;437(1):53-61.
2011: Rebekka Mindnich; Jason E Drury; Trevor M Penning
The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function.
Chemico-biological interactions 2011;191(1-3):250-4.
2011: Trevor M Penning
Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.
The Journal of steroid biochemistry and molecular biology 2011;125(1-2):46-56.
2011: Michael C Byrns; Yi Jin; Trevor M Penning
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.
The Journal of steroid biochemistry and molecular biology 2011;125(1-2):95-104.
2011: Mo Chen; Jason E Drury; Trevor M Penning
Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1).
Steroids 2011;76(5):484-90.
2011: Adegoke O Adeniji; Barry M Twenter; Michael C Byrns; Yi Jin; Jeffrey D Winkler; Trevor M Penning
Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).
Bioorganic & medicinal chemistry letters 2011;21(5):1464-8.
2011: Stacy L Gelhaus; Ronald G Harvey; Trevor M Penning; Ian A Blair
Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells.
Chemical research in toxicology 2011;24(1):89-98.
2010: Jason E Drury; Rebekka Mindnich; Trevor M Penning
Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency.
The Journal of biological chemistry 2010;285(32):24529-37.
2010: Trevor M Penning; Seon-Hwa Lee; Yi Jin; Alejandro Gutierrez; Ian A Blair
Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.
The Journal of steroid biochemistry and molecular biology 2010;121(3-5):546-55.
2010: Richard A Ashley; Zhongxin Yu; Kar-Ming Fung; Dominic Frimberger; Bradley P Kropp; Trevor M Penning; Hsueh-Kung Lin
Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis.
Urology 2010;76(1):67-72.
2010: Trevor M Penning
New frontiers in androgen biosynthesis and metabolism.
Current opinion in endocrinology, diabetes, and obesity 2010;17(3):233-9.
2010: Karen E Knudsen; Trevor M Penning
Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer.
Trends in endocrinology and metabolism: TEM 2010;21(5):315-24.
2010: Michael C Byrns; Ling Duan; Seon Hwa Lee; Ian A Blair; Trevor M Penning
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.
The Journal of steroid biochemistry and molecular biology 2010;118(3):177-87.
2009: Jong-Heum Park; Dipti Mangal; Alexander J Frey; Ronald G Harvey; Ian Blair; Trevor M Penning
Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione.
The Journal of biological chemistry 2009;284(43):29725-34.
2009: A Kenneth MacLeod; Michael McMahon; Simon M Plummer; Larry G Higgins; Trevor M Penning; Kazuhiko Igarashi; John D Hayes
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
Carcinogenesis 2009;30(9):1571-80.
2009: Jason E Drury; Luigi Di Costanzo; Trevor M Penning; David W Christianson
Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex.
The Journal of biological chemistry 2009;284(30):19786-90.
2009: Rebekka Mindnich; Trevor M Penning
Aldo-keto reductase (AKR) superfamily: genomics and annotation.
Human genomics 2009;3(4):362-70.
2009: Mikhail G Dozmorov; Robert E Hurst; Daniel J Culkin; Bradley P Kropp; Mark Barton Frank; Jeanette Osban; Trevor M Penning; Hsueh-Kung Lin
Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells.
The Prostate 2009;69(10):1077-90.
2009: Dipti Mangal; Daljit Vudathala; Jong-Heum Park; Seon Hwa Lee; Trevor M Penning; Ian A Blair
Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.
Chemical research in toxicology 2009;22(5):788-97.
2009: Yi Jin; Ling Duan; Seon Hwa Lee; Helenius J Kloosterboer; Ian A Blair; Trevor M Penning
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.
The Journal of biological chemistry 2009;284(15):10013-22.
2009: Luigi Di Costanzo; Jason Drury; David W Christianson; Trevor M Penning
Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1).
Molecular and cellular endocrinology 2009;301(1-2):191-8.
2009: Luigi Di Costanzo; Trevor M Penning; David W Christianson
Aldo-keto reductases in which the conserved catalytic histidine is substituted.
Chemico-biological interactions 2009;178(1-3):127-33.
2009: Bengt Persson; Yvonne Kallberg; James E Bray; Elspeth Bruford; Stephen L Dellaporta; Angelo D Favia; Roser Gonzalez Duarte; Hans Jörnvall; Kathryn L Kavanagh; Natalia Kedishvili; Michael Kisiela; Edmund Maser; Rebekka Mindnich; Sandra Orchard; Trevor M Penning; Janet M Thornton; Jerzy Adamski; Udo Oppermann
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
Chemico-biological interactions 2009;178(1-3):94-8.
2009: Michael C Byrns; Trevor M Penning
Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.
Chemico-biological interactions 2009;178(1-3):221-7.
2009: Moira R Nicol; Georgia Papacleovoulou; Dean B Evans; Trevor M Penning; Mark W J Strachan; Andrew Advani; Sarah J Johnson; Richard Quinton; J Ian Mason
Estrogen biosynthesis in human H295 adrenocortical carcinoma cells.
Molecular and cellular endocrinology 2009;300(1-2):115-20.
2009: Trevor M Penning; Michael C Byrns
Steroid hormone transforming aldo-keto reductases and cancer.
Annals of the New York Academy of Sciences 2009;1155():33-42.
2009: Daiwang Xu; Trevor M Penning; Ian Blair; Ronald G Harvey
Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer.
The Journal of organic chemistry 2009;74(2):597-604.
2009: Joseph T Azzarello; Hsueh-Kung Lin; Awet Gherezghiher; Vladislav Zakharov; Zhongxin Yu; Bradley P Kropp; Daniel J Culkin; Trevor M Penning; Kar-Ming Fung
Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor.
International journal of clinical and experimental pathology 2009;3(2):147-55.
2008: Amy M Quinn; Ronald G Harvey; Trevor M Penning
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
Chemical research in toxicology 2008;21(11):2207-15.
2008: Trevor M Penning; Caryn Lerman
Genomics of smoking exposure and cessation: lessons for cancer prevention and treatment.
Cancer prevention research (Philadelphia, Pa.) 2008;1(2):80-3.
2008: Luigi Di Costanzo; Jason Drury; Trevor M Penning; David W Christianson
Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis.
The Journal of biological chemistry 2008;283(24):16830-9.
2008: Jong-Heum Park; Dipti Mangal; Kirk A Tacka; Amy M Quinn; Ronald G Harvey; Ian A Blair; Trevor M Penning
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6846-51.
2008: Jong-Heum Park; Stacy Gelhaus; Srilakshmi Vedantam; Andrea L Oliva; Abhita Batra; Ian A Blair; Andrea B Troxel; Jeffrey Field; Trevor M Penning
The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.
Chemical research in toxicology 2008;21(5):1039-49.
2008: Amy M Quinn; Trevor M Penning
Comparisons of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol activation by human cytochrome P450 and aldo-keto reductase enzymes: effect of redox state and expression levels.
Chemical research in toxicology 2008;21(5):1086-94.
2008: Daiwang Xu; Yazhen Duan; Ian Blair; Trevor M Penning; Ronald G Harvey
Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues.
Organic letters 2008;10(6):1059-62.
2008: Carol A Shultz; Nisha Palackal; Dipti Mangal; Ronald G Harvey; Ian A Blair; Trevor M Penning
Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preference.
Chemical research in toxicology 2008;21(3):668-77.
2008: Chongzhao Ran; Qing Dai; Qian Ruan; Trevor M Penning; Ian Blair; Ronald G Harvey
Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides.
The Journal of organic chemistry 2008;73(3):992-1003.
2008: Trevor M Penning; Yi Jin; Tea Lanisnik Rizner; David R Bauman
Pre-receptor regulation of the androgen receptor.
Molecular and cellular endocrinology 2008;281(1-2):1-8.
2008: Michael C Byrns; Stephan Steckelbroeck; Trevor M Penning
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies.
Biochemical pharmacology 2008;75(2):484-93.
2007: William C Cooper; Yi Jin; Trevor M Penning
Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9).
The Journal of biological chemistry 2007;282(46):33484-93.
2007: Hao Jiang; Stacy L Gelhaus; Dipti Mangal; Ronald G Harvey; Ian A Blair; Trevor M Penning
Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry.
Chemical research in toxicology 2007;20(9):1331-41.
2007: Trevor M Penning; Jason Drury
Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.
Archives of biochemistry and biophysics 2007;464(2):241-50.
2007: Qian Ruan; Stacy L Gelhaus; Trevor M Penning; Ronald G Harvey; Ian A Blair
Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells.
Chemical research in toxicology 2007;20(3):424-31.
2007: M Cecilia Caino; José Luis Oliva; Hao Jiang; Trevor M Penning; Marcelo G Kazanietz
Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells.
Molecular pharmacology 2007;71(3):744-50.
2007: Trevor M Penning; David R Bauman; Yi Jin; Tea Lanisnik Rizner
Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor.
Molecular and cellular endocrinology 2007;265-266():77-82.
2007: Yi Jin; Trevor M Penning
Aldo-keto reductases and bioactivation/detoxication.
Annual review of pharmacology and toxicology 2007;47():263-92.
2006: David R Bauman; Stephan Steckelbroeck; Donna M Peehl; Trevor M Penning
Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.
Endocrinology 2006;147(12):5806-16.
2006: Yu-Min Shen; Andrea B Troxel; Srilakshmi Vedantam; Trevor M Penning; Jeffrey Field
Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection.
Chemical research in toxicology 2006;19(11):1441-50.
2006: Yi Jin; Trevor M Penning
Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.
Biochemistry 2006;45(43):13054-63.
2006: Dominic J Yee; Vojtech Balsanek; David R Bauman; Trevor M Penning; Dalibor Sames
Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13304-9.
2006: Jong-Heum Park; Andrea B Troxel; Ronald G Harvey; Trevor M Penning
Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species.
Chemical research in toxicology 2006;19(5):719-28.
2006: Yi Jin; Trevor M Penning
Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences.
Steroids 2006;71(5):380-91.
2006: Trevor M Penning; Stephan Steckelbroeck; David R Bauman; Meredith W Miller; Yi Jin; Donna M Peehl; Kar-Ming Fung; Hsueh-Kung Lin
Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.
Molecular and cellular endocrinology 2006;248(1-2):182-91.
2006: Tea Lanisnik Rizner; Tina Smuc; Ruth Rupreht; Jasna Sinkovec; Trevor M Penning
AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.
Molecular and cellular endocrinology 2006;248(1-2):126-35.
2006: Kamalesh K Sharma; Annika Lindqvist; Xin J Zhou; Richard J Auchus; Trevor M Penning; A S Andersson
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
Molecular and cellular endocrinology 2006;248(1-2):79-86.
2006: Kar-Ming Fung; E N S Samara; Carson Wong; Adam R Metwalli; R Krlin; Barbara Bane; C Z Liu; JT Yang; Jan V Pitha; Daniel J Culkin; Bradley P Kropp; Trevor M Penning; Hsueh-Kung Lin
Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.
Endocrine-related cancer 2006;13(1):169-80.
2006: Michael Stanbrough; Glenn J Bubley; Kenneth Ross; Todd R Golub; Mark A Rubin; Trevor M Penning; Phillip G Febbo; Steven P Balk
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.
Cancer research 2006;66(5):2815-25.
2006: Stephan Steckelbroeck; Busola Oyesanmi; Yi Jin; Seon-Hwa Lee; Helenius J Kloosterboer; Trevor M Penning
Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1300-9.
2006: David R Bauman; Stephan Steckelbroeck; Michelle V Williams; Donna M Peehl; Trevor M Penning
Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease.
Molecular endocrinology (Baltimore, Md.) 2006;20(2):444-58.
2006: Qian Ruan; Hye-Young H Kim; Hao Jiang; Trevor M Penning; Ronald G Harvey; Ian A Blair
Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2006;20(8):1369-80.
2006: Hao Jiang; Daljit K Vudathala; Ian A Blair; Trevor M Penning
Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction.
Chemical research in toxicology 2006;19(1):68-78.
2005: Jun Gao; Andrew A Voss; Isaac N Pessah; Fredine T Lauer; Trevor M Penning; Scott W Burchiel
Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(2):419-26.
2005: Jong-Heum Park; Sridhar Gopishetty; Lawrence szewczuk; Andrea B Troxel; Ronald G Harvey; Trevor M Penning
Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling.
Chemical research in toxicology 2005;18(6):1026-37.
2005: Trevor M Penning
AKR1B10: a new diagnostic marker of non-small cell lung carcinoma in smokers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1687-90.
2005: Hao Jiang; Yu-Min Shen; Amy M Quinn; Trevor M Penning
Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts.
Chemical research in toxicology 2005;18(2):365-74.
2005: Lawrence szewczuk; Seon Hwa Lee; Ian A Blair; Trevor M Penning
Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol.
Journal of natural products 2005;68(1):36-42.
2005: David R Bauman; Stephen I Rudnick; Lawrence szewczuk; Yi Jin; Sridhar Gopishetty; Trevor M Penning
Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes.
Molecular pharmacology 2005;67(1):60-8.
2004: Hsueh-Kung Lin; Stephan Steckelbroeck; Kar-Ming Fung; Amy N Jones; Trevor M Penning
Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate.
Steroids 2004;69(13-14):795-801.
2004: Stephan Steckelbroeck; Yi Jin; Busola Oyesanmi; Helenius J Kloosterboer; Trevor M Penning
Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.
Molecular pharmacology 2004;66(6):1702-11.
2004: David R Bauman; Stephan Steckelbroeck; Trevor M Penning
The roles of aldo-keto reductases in steroid hormone action.
Drug news & perspectives 2004;17(9):563-78.
2004: Lawrence szewczuk; Trevor M Penning
Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study.
Journal of natural products 2004;67(11):1777-82.
2004: Vladi V Heredia; Trevor M Penning
Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis.
Biochemistry 2004;43(38):12028-37.
2004: Christine Patte-Mensah; Trevor M Penning; Ayikoe G Mensah-Nyagan
Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord.
The Journal of comparative neurology 2004;477(3):286-99.
2004: Lawrence szewczuk; Luca Forti; Lucia A Stivala; Trevor M Penning
Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents.
The Journal of biological chemistry 2004;279(21):22727-37.
2004: Vladi V Heredia; William C Cooper; Ryan G Kruger; Yi Jin; Trevor M Penning
Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.
Biochemistry 2004;43(19):5832-41.
2004: Ronald G Harvey; Qing Dai; Chongzhao Ran; Trevor M Penning
Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis.
The Journal of organic chemistry 2004;69(6):2024-32.
2004: Stephan Steckelbroeck; Yi Jin; Sridhar Gopishetty; Busola Oyesanmi; Trevor M Penning
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.
The Journal of biological chemistry 2004;279(11):10784-95.
2004: Trevor M Penning; Yi Jin; Stephan Steckelbroeck; T Lanisnik Rizner; Mitchell Lewis
Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.
Molecular and cellular endocrinology 2004;215(1-2):63-72.
2004: Trevor M Penning
Aldo-keto reductases and formation of polycyclic aromatic hydrocarbon o-quinones.
Methods in enzymology 2004;378():31-67.
2003: Tea Lanisnik Rizner; Hsueh-Kung Lin; Donna M Peehl; Stephan Steckelbroeck; David R Bauman; Trevor M Penning
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
Endocrinology 2003;144(7):2922-32.
2003: Trevor M Penning; Yi Jin; Vladi V Heredia; Mitchell Lewis
Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):247-55.
2003: Trevor M Penning
Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action.
Human reproduction update 2003;9(3):193-205.
2003: David J Hyndman; David R Bauman; Vladi V Heredia; Trevor M Penning
The aldo-keto reductase superfamily homepage.
Chemico-biological interactions 2003;143-144():621-31.
2003: Tea Lanisnik Rizner; Hsueh-Kung Lin; Trevor M Penning
Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells.
Chemico-biological interactions 2003;143-144():401-9.
2003: Vladi V Heredia; Ryan G Kruger; Trevor M Penning
Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9).
Chemico-biological interactions 2003;143-144():393-400.
2003: Yi Jin; William C Cooper; Trevor M Penning
Examination of the differences in structure-function of human and rat 3alpha-hydroxysteroid dehydrogenase.
Chemico-biological interactions 2003;143-144():383-92.
2002: Deshan Yu; Marcelo G Kazanietz; Ronald G Harvey; Trevor M Penning
Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C.
Biochemistry 2002;41(39):11888-94.
2002: Nisha Palackal; Seon Hwa Lee; Ronald G Harvey; Ian A Blair; Trevor M Penning
Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.
The Journal of biological chemistry 2002;277(27):24799-808.
2002: Deshan Yu; Jesse A Berlin; Trevor M Penning; Jeffrey Field
Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.
Chemical research in toxicology 2002;15(6):832-42.
2001: Nisha Palackal; Michael Burczynski; Ronald G Harvey; Trevor M Penning
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.
Biochemistry 2001;40(36):10901-10.
2001: Yi Jin; Steven E Stayrook; R H Albert; Nisha Palackal; Trevor M Penning; Mitchell Lewis
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
Biochemistry 2001;40(34):10161-8.
2001: L Tsuruda; Trevor M Penning
Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death.
Chemical research in toxicology 2001;14(7):856-62.
2001: Yi Jin; Trevor M Penning
Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism.
Best practice & research. Clinical endocrinology & metabolism 2001;15(1):79-94.
2001: Nisha Palackal; Michael Burczynski; Ronald G Harvey; Trevor M Penning
Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).
Chemico-biological interactions 2001;130-132(1-3):815-24.
2001: Trevor M Penning; H Ma; Joseph M Jez
Engineering steroid hormone specificity into aldo-keto reductases.
Chemico-biological interactions 2001;130-132(1-3):659-71.
2001: Michael Burczynski; G R Sridhar; Nisha Palackal; Trevor M Penning
The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.
The Journal of biological chemistry 2001;276(4):2890-7.
2001: Trevor M Penning; Michael Burczynski; Joseph M Jez; Hsueh-Kung Lin; H Ma; M Moore; K Ratnam; Nisha Palackal
Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
Molecular and cellular endocrinology 2001;171(1-2):137-49.
2000: Trevor M Penning; Michael Burczynski; Joseph M Jez; Chien-Fu Hung; Hsueh-Kung Lin; H Ma; M Moore; Nisha Palackal; K Ratnam
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
The Biochemical journal 2000;351(Pt 1):67-77.
2000: Michael Burczynski; Trevor M Penning
Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
Cancer research 2000;60(4):908-15.
2000: H Ma; K Ratnam; Trevor M Penning
Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding.
Biochemistry 2000;39(1):102-9.
1999: Hsueh-Kung Lin; Chien-Fu Hung; M Moore; Trevor M Penning
Genomic structure of rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD, AKR1C9).
The Journal of steroid biochemistry and molecular biology 1999;71(1-2):29-39.
1999: Chien-Fu Hung; Trevor M Penning
Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD AKR1C9) gene expression: a member of the aldo-keto reductase superfamily.
Molecular endocrinology (Baltimore, Md.) 1999;13(10):1704-17.
1999: H Ma; Trevor M Penning
Conversion of mammalian 3alpha-hydroxysteroid dehydrogenase to 20alpha-hydroxysteroid dehydrogenase using loop chimeras: changing specificity from androgens to progestins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11161-6.
1999: H Ma; Trevor M Penning
Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile.
The Biochemical journal 1999;341 ( Pt 3)():853-9.
1999: K Ratnam; H Ma; Trevor M Penning
The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase.
Biochemistry 1999;38(24):7856-64.
1999: Trevor M Penning
Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3alpha-hydroxysteroid dehydrogenase.
The Journal of steroid biochemistry and molecular biology 1999;69(1-6):211-25.
1999: K D McCoull; D Rindgen; Ian A Blair; Trevor M Penning
Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts.
Chemical research in toxicology 1999;12(3):237-46.
1999: Michael Burczynski; Hsueh-Kung Lin; Trevor M Penning
Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
Cancer research 1999;59(3):607-14.
1999: Trevor M Penning; Michael Burczynski; Chien-Fu Hung; K D McCoull; Nisha Palackal; L S Tsuruda
Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones.
Chemical research in toxicology 1999;12(1):1-18.
1998: BP Schlegel; K Ratnam; Trevor M Penning
Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine.
Biochemistry 1998;37(31):11003-11.
1998: Joseph M Jez; Trevor M Penning
Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase.
Biochemistry 1998;37(27):9695-703.
1998: Michael Burczynski; Ronald G Harvey; Trevor M Penning
Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
Biochemistry 1998;37(19):6781-90.
1998: BP Schlegel; Joseph M Jez; Trevor M Penning
Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases.
Biochemistry 1998;37(10):3538-48.
1998: Y T Hou; Hsueh-Kung Lin; Trevor M Penning
Dexamethasone regulation of the rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase gene.
Molecular pharmacology 1998;53(3):459-66.
1997: Hsueh-Kung Lin; Joseph M Jez; BP Schlegel; Donna M Peehl; J A Pachter; Trevor M Penning
Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.
Molecular endocrinology (Baltimore, Md.) 1997;11(13):1971-84.
1997: Joseph M Jez; T G Flynn; Trevor M Penning
A new nomenclature for the aldo-keto reductase superfamily.
Biochemical pharmacology 1997;54(6):639-47.
1997: Joseph M Jez; Melanie Bennett; BP Schlegel; Mitchell Lewis; Trevor M Penning
Comparative anatomy of the aldo-keto reductase superfamily.
The Biochemical journal 1997;326 ( Pt 3)():625-36.
1997: L Flowers; S T Ohnishi; Trevor M Penning
DNA strand scission by polycyclic aromatic hydrocarbon o-quinones: role of reactive oxygen species, Cu(II)/Cu(I) redox cycling, and o-semiquinone anion radicals,.
Biochemistry 1997;36(28):8640-8.
1997: M S Tang; R A Copeland; Trevor M Penning
Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE.
Biochemistry 1997;36(24):7527-34.
1997: Melanie Bennett; R H Albert; Joseph M Jez; H Ma; Trevor M Penning; Mitchell Lewis
Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Structure (London, England : 1993) 1997;5(6):799-812.
1997: Trevor M Penning
Molecular endocrinology of hydroxysteroid dehydrogenases.
Endocrine reviews 1997;18(3):281-305.
1997: Trevor M Penning; J E Pawlowski; BP Schlegel; Joseph M Jez; Hsueh-Kung Lin; S S Hoog; Melanie Bennett; Mitchell Lewis
"Mammalian 3 alpha-hydroxysteroid dehydrogenases".
Steroids 1997;62(5):455-6.
1997: M S Tang; L J Askonas; Trevor M Penning
Bromoacetamido-analogs of indomethacin and mefenamic acid affinity-label prostaglandin H2 synthase at two sites.
Advances in experimental medicine and biology 1997;400A():77-84.
1997: Joseph M Jez; T G Flynn; Trevor M Penning
A nomenclature system for the aldo-keto reductase superfamily.
Advances in experimental medicine and biology 1997;414():579-600.
1997: Trevor M Penning
Hydroxysteroid dehydrogenases. New drug targets of the aldo-keto reductase superfamily.
Advances in experimental medicine and biology 1997;414():475-90.
1997: Trevor M Penning; Melanie Bennett; S Smith-Hoog; BP Schlegel; Joseph M Jez; Mitchell Lewis
Structure and function of 3 alpha-hydroxysteroid dehydrogenase.
Steroids 1997;62(1):101-11.
1996: Joseph M Jez; BP Schlegel; Trevor M Penning
Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence.
The Journal of biological chemistry 1996;271(47):30190-8.
1996: L Flowers; W F Bleczinski; Michael Burczynski; R G Harvey; Trevor M Penning
Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase.
Biochemistry 1996;35(42):13664-72.
1996: Trevor M Penning
3 alpha-hydroxysteroid dehydrogenase: three dimensional structure and gene regulation.
The Journal of endocrinology 1996;150 Suppl():S175-87.
1996: Trevor M Penning; J E Pawlowski; BP Schlegel; Joseph M Jez; Hsueh-Kung Lin; S S Hoog; Melanie Bennett; Mitchell Lewis
Mammalian 3 alpha-hydroxysteroid dehydrogenases.
Steroids 1996;61(9):508-23.
1996: Melanie Bennett; BP Schlegel; Joseph M Jez; Trevor M Penning; Mitchell Lewis
Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
Biochemistry 1996;35(33):10702-11.
1996: L Flowers-Geary; W Bleczinki; R G Harvey; Trevor M Penning
Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase.
Chemico-biological interactions 1996;99(1-3):55-72.
1996: Trevor M Penning; S T Ohnishi; T Ohnishi; R G Harvey
Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase.
Chemical research in toxicology 1996;9(1):84-92.
1995: L Flowers-Geary; R G Harvey; Trevor M Penning
Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes.
Carcinogenesis 1995;16(11):2707-15.
1995: Hsueh-Kung Lin; Trevor M Penning
Cloning, sequencing, and functional analysis of the 5'-flanking region of the rat 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase gene.
Cancer research 1995;55(18):4105-13.
1995: M S Tang; L J Askonas; Trevor M Penning
Bromoacetamido analogs of indomethacin and mefenamic acid as affinity-labeling agents and mechanistic probes for prostaglandin H2 synthase.
Biochemistry 1995;34(3):808-15.
1994: BP Schlegel; J E Pawlowski; Y Hu; D M Scolnick; D F Covey; Trevor M Penning
Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase.
Biochemistry 1994;33(34):10367-74.
1994: J E Pawlowski; Trevor M Penning
Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.
The Journal of biological chemistry 1994;269(18):13502-10.
1994: S S Hoog; J E Pawlowski; Pedro Alzari; Trevor M Penning; Mitchell Lewis
Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2517-21.
1994: Y T Hou; W Xia; J E Pawlowski; Trevor M Penning
Rat dihydrodiol dehydrogenase: complexity of gene structure and tissue-specific and sexually dimorphic gene expression.
Cancer research 1994;54(1):247-55.
1993: Trevor M Penning
Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism.
Chemico-biological interactions 1993;89(1):1-34.
1993: L Flowers-Geary; R G Harvey; Trevor M Penning
Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells.
Chemical research in toxicology 1993;6(3):252-60.
1993: M Shou; R G Harvey; Trevor M Penning
Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.
Carcinogenesis 1993;14(3):475-82.
1992: V S Murty; Trevor M Penning
Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione.
Chemico-biological interactions 1992;84(2):169-88.
1992: M Shou; R G Harvey; Trevor M Penning
Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions.
Carcinogenesis 1992;13(9):1575-82.
1992: L Flowers-Geary; R G Harvey; Trevor M Penning
Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase.
Chemical research in toxicology 1992;5(4):576-83.
1992: V S Murty; Trevor M Penning
Characterization of mercapturic acid and glutathionyl conjugates of benzo[a]pyrene-7,8-dione by two-dimensional NMR.
Bioconjugate chemistry 1992;3(3):218-24.
1992: Trevor M Penning; K Isaacson; C R Lyttle
Hormonal regulation of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol.
Biochemical pharmacology 1992;43(5):1148-51.
1991: L J Askonas; Trevor M Penning
Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: labeling of the nonsteroidal anti-inflammatory drug binding site of 3 alpha-hydroxysteroid dehydrogenase.
Biochemistry 1991;30(49):11553-60.
1991: L J Askonas; J W Ricigliano; Trevor M Penning
The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs.
The Biochemical journal 1991;278 ( Pt 3)():835-41.
1991: J Pawlowski; M Huizinga; Trevor M Penning
Isolation and partial characterization of a full-length cDNA clone for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme for nonsteroidal anti-inflammatory drugs.
Agents and actions 1991;34(1-2):289-93.
1991: Trevor M Penning; R Thronton; J W Ricigliano
Clues to the development of mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides.
Steroids 1991;56(8):420-7.
1991: Trevor M Penning; William Abrams; J E Pawlowski
Affinity labeling of 3 alpha-hydroxysteroid dehydrogenase with 3 alpha-bromoacetoxyandrosterone and 11 alpha-bromoacetoxyprogesterone. Isolation and sequence of active site peptides containing reactive cysteines; sequence confirmation using nucleotide sequence from a cDNA clone.
The Journal of biological chemistry 1991;266(14):8826-34.
1991: J E Pawlowski; M Huizinga; Trevor M Penning
Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
The Journal of biological chemistry 1991;266(14):8820-5.
1991: Matthew P Hardy; S J Gelber; Z F Zhou; Trevor M Penning; J W Ricigliano; V K Ganjam; DJ Nonneman; L L Ewing
Hormonal control of Leydig cell differentiation.
Annals of the New York Academy of Sciences 1991;637():152-63.
1991: Trevor M Penning; J W Ricigliano
Mechanism based inhibition of hydroxysteroid dehydrogenases.
Journal of enzyme inhibition 1991;5(3):165-98.
1990: J W Ricigliano; Trevor M Penning
Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3 alpha-hydroxysteroid dehydrogenase.
The Biochemical journal 1990;269(3):749-55.
1990: Trevor M Penning; R B Sharp
Characterization of dihydrodiol dehydrogenase in human liver and lung.
Carcinogenesis 1990;11(7):1203-8.
1989: A L Buller; R B Sharp; Trevor M Penning
Characterization of dihydrodiol dehydrogenase in rat H-4IIe hepatoma cells.
Cancer research 1989;49(24 Pt 1):6976-80.
1989: J W Ricigliano; Trevor M Penning
Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase.
The Biochemical journal 1989;262(1):139-49.
1989: Trevor M Penning; R B Sharp; T E Smithgall
Non-K-region o-quinones as enzyme-generated inactivators of dihydrodiol dehydrogenase.
Biochemistry 1989;28(10):4505-11.
1988: T E Smithgall; Trevor M Penning
Electrophoretic and immunochemical characterization of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues.
The Biochemical journal 1988;254(3):715-21.
1988: R B Sharp; Trevor M Penning
Inhibition of progesterone synthesis in normal and transformed human placental cells by tight binding inhibitors of 3 beta-hydroxysteroid dehydrogenase.
Steroids 1988;51(5-6):441-57.
1988: T E Smithgall; R G Harvey; Trevor M Penning
Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a)anthracene and other benz(a)anthracene derivatives by 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase: effects of methyl substitution on velocity and stereochemical course of trans-dihydrodiol oxidation.
Cancer research 1988;48(5):1227-32.
1988: T E Smithgall; R G Harvey; Trevor M Penning
Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism.
The Journal of biological chemistry 1988;263(4):1814-20.
1987: Trevor M Penning; R B Sharp
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
Biochemical and biophysical research communications 1987;148(2):646-52.
1987: Trevor M Penning; Kenneth Carlson; R B Sharp
Affinity-labelling of the anti-inflammatory drug and prostaglandin-binding site of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol with 17 beta- and 21-bromoacetoxysteroids.
The Biochemical journal 1987;245(1):269-76.
1986: J W Ricigliano; Trevor M Penning
Active-site directed inactivation of rat ovarian 20 alpha-hydroxysteroid dehydrogenase.
The Biochemical journal 1986;240(3):717-23.
1986: Trevor M Penning; T E Smithgall; L J Askonas; R B Sharp
Rat liver 3 alpha-hydroxysteroid dehydrogenase.
Steroids 1986;47(4-5):221-47.
1985: Trevor M Penning; R B Sharp; N R Krieger
Purification and properties of 3 alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins.
The Journal of biological chemistry 1985;260(28):15266-72.
1985: R B Sharp; M B Senior; Trevor M Penning
Potent inhibition of mammalian progesterone synthesis by 2 alpha-cyanoprogesterone.
The Biochemical journal 1985;230(3):587-94.