Josef Penninger

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Nagatake Takahiro; Fukuyama Satoshi; Kim Dong-Young; Goda Kaoru; Igarashi Osamu; Sato Shintaro; Nochi Tomonori; Sagara Hiroshi; Yokota Yoshifumi; Jetten Anton M; Kaisho Tsuneyasu; Akira Shizuo; Mimuro Hitomi; Sasakawa Chihiro; Fukui Yoshinori; Fujihashi Kohtaro; Akiyama Taishin; Inoue Jun-ichiro; Penninger Josef M; Kunisawa Jun; Kiyono Hiroshi
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
Leibbrandt A; Penninger J M
ESCI award lecture: from a little mouse to rationale medicine for bone loss.
Blyszczuk Przemyslaw; Kania Gabriela; Dieterle Thomas; Marty Rene R; Valaperti Alan; Berthonneche Corinne; Pedrazzini Thierry; Berger Christoph T; Dirnhofer Stephan; Matter Christian M; Penninger Josef M; Lüscher Thomas F; Eriksson Urs
Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.

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All Publications

2009: Nagatake Takahiro; Fukuyama Satoshi; Kim Dong-Young; Goda Kaoru; Igarashi Osamu; Sato Shintaro; Nochi Tomonori; Sagara Hiroshi; Yokota Yoshifumi; Jetten Anton M; Kaisho Tsuneyasu; Akira Shizuo; Mimuro Hitomi; Sasakawa Chihiro; Fukui Yoshinori; Fujihashi Kohtaro; Akiyama Taishin; Inoue Jun-ichiro; Penninger Josef M; Kunisawa Jun; Kiyono Hiroshi
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2009: Leibbrandt A; Penninger J M
ESCI award lecture: from a little mouse to rationale medicine for bone loss.
European journal of clinical investigation 2009;39(10):842-50.
2009: Blyszczuk Przemyslaw; Kania Gabriela; Dieterle Thomas; Marty Rene R; Valaperti Alan; Berthonneche Corinne; Pedrazzini Thierry; Berger Christoph T; Dirnhofer Stephan; Matter Christian M; Penninger Josef M; Lüscher Thomas F; Eriksson Urs
Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.
Circulation research 2009;105(9):912-20.
2009: Köcher Thomas; Pichler Peter; Schutzbier Michael; Stingl Christoph; Kaul Axel; Teucher Nils; Hasenfuss Gerd; Penninger Josef M; Mechtler Karl
High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all.
Journal of proteome research 2009;8(10):4743-52.
2009: Kassiri Zamaneh; Zhong Jiuchang; Guo Danny; Basu Ratnadeep; Wang Xiuhua; Liu Peter P; Scholey James W; Penninger Josef M; Oudit Gavin Y
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.
Circulation. Heart failure 2009;2(5):446-55.
2009: Paolino Magdalena; Penninger Josef M
E3 ubiquitin ligases in T-cell tolerance.
European journal of immunology 2009;39(9):2337-44.
2009: Osterreicher Christoph H; Taura Kojiro; De Minicis Samuele; Seki Ekihiro; Penz-Osterreicher Melitta; Kodama Yuzo; Kluwe Johannes; Schuster Manfred; Oudit Gavin Y; Penninger Josef M; Brenner David A
Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice.
Hepatology (Baltimore, Md.) 2009;50(3):929-38.
2009: Joza Nicholas; Pospisilik J Andrew; Hangen Emilie; Hanada Toshikatsu; Modjtahedi Nazanine; Penninger Josef M; Kroemer Guido
AIF: not just an apoptosis-inducing factor.
Annals of the New York Academy of Sciences 2009;1171():2-11.
2009: Cronin Shane J F; Nehme Nadine T; Limmer Stefanie; Liegeois Samuel; Pospisilik J Andrew; Schramek Daniel; Leibbrandt Andreas; Simoes Ricardo de Matos; Gruber Susanne; Puc Urszula; Ebersberger Ingo; Zoranovic Tamara; Neely G Gregory; von Haeseler Arndt; Ferrandon Dominique; Penninger Josef M
Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection.
Science (New York, N.Y.) 2009;325(5938):340-3.
2009: Singer Dustin; Camargo Simone M R; Huggel Katja; Romeo Elisa; Danilczyk Ursula; Kuba Keiji; Chesnov Serge; Caron Marc G; Penninger Josef M; Verrey Francois
Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.
The Journal of biological chemistry 2009;284(30):19953-60.
2009: Oudit G Y; Kassiri Z; Jiang C; Liu P P; Poutanen S M; Penninger J M; Butany J
SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.
European journal of clinical investigation 2009;39(7):618-25.
2009: Oudit Gavin Y; Imai Yumiko; Kuba Keiji; Scholey James W; Penninger Josef M
The role of ACE2 in pulmonary diseases--relevance for the nephrologist.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009;24(5):1362-5.
2009: Oudit Gavin Y; Penninger Josef M
Cardiac regulation by phosphoinositide 3-kinases and PTEN.
Cardiovascular research 2009;82(2):250-60.
2009: Camargo Simone M R; Singer Dustin; Makrides Victoria; Huggel Katja; Pos Klaas M; Wagner Carsten A; Kuba Keiji; Danilczyk Ursula; Skovby Flemming; Kleta Robert; Penninger Josef M; Verrey François
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Gastroenterology 2009;136(3):872-82.
2009: Tanemura Shuhei; Momose Haruka; Shimizu Nao; Kitagawa Daiju; Seo Jungwon; Yamasaki Tokiwa; Nakagawa Kentaro; Kajiho Hiroaki; Penninger Josef M; Katada Toshiaki; Nishina Hiroshi
Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.
Journal of biochemistry 2009;145(3):345-54.
2009: Mizoguchi Toshihide; Muto Akinori; Udagawa Nobuyuki; Arai Atsushi; Yamashita Teruhito; Hosoya Akihiro; Ninomiya Tadashi; Nakamura Hiroaki; Yamamoto Yohei; Kinugawa Saya; Nakamura Midori; Nakamichi Yuko; Kobayashi Yasuhiro; Nagasawa Sakae; Oda Kimimitsu; Tanaka Hirofumi; Tagaya Mitsuo; Penninger Josef M; Ito Michio; Takahashi Naoyuki
Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.
The Journal of cell biology 2009;184(4):541-54.
2009: Fontán-Lozano Angela; Romero-Granados Rocío; del-Pozo-Martín Yaiza; Suárez-Pereira Irene; Delgado-García José María; Penninger Josef M; Carrión Angel Manuel
Lack of DREAM protein enhances learning and memory and slows brain aging.
Current biology : CB 2009;19(1):54-60.
2009: Leibbrandt Andreas; Penninger Josef M
RANK(L) as a Key Target for Controlling Bone Loss.
Advances in experimental medicine and biology 2009;647():130-45.
2009: Leibbrandt Andreas; Penninger Josef M
RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies.
Advances in experimental medicine and biology 2009;649():100-13.
2009: Gruber Thomas; Hermann-Kleiter Natascha; Hinterleitner Reinhard; Fresser Friedrich; Schneider Rainer; Gastl Günther; Penninger Josef M; Baier Gottfried
PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.
Science signaling 2009;2(76):ra30.
2008: Reich Heather N; Oudit Gavin Y; Penninger Josef M; Scholey James W; Herzenberg Andrew M
Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease.
Kidney international 2008;74(12):1610-6.
2008: Raberger Julia; Boucheron Nicole; Sakaguchi Shinya; Penninger Josef M; Ellmeier Wilfried
Impaired T-cell development in the absence of Vav1 and Itk.
European journal of immunology 2008;38(12):3530-42.
2008: Lovren Fina; Pan Yi; Quan Adrian; Teoh Hwee; Wang Guilin; Shukla Praphulla C; Levitt Kevin S; Oudit Gavin Y; Al-Omran Mohammed; Stewart Duncan J; Slutsky Arthur S; Peterson Mark D; Backx Peter H; Penninger Josef M; Verma Subodh
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1377-84.
2008: Hikosaka Yu; Nitta Takeshi; Ohigashi Izumi; Yano Kouta; Ishimaru Naozumi; Hayashi Yoshio; Matsumoto Mitsuru; Matsuo Koichi; Penninger Josef M; Takayanagi Hiroshi; Yokota Yoshifumi; Yamada Hisakata; Yoshikai Yasunobu; Inoue Jun-Ichiro; Akiyama Taishin; Takahama Yousuke
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Immunity 2008;29(3):438-50.
2008: Akiyama Taishin; Shimo Yusuke; Yanai Hiromi; Qin Junwen; Ohshima Daisuke; Maruyama Yuya; Asaumi Yukiko; Kitazawa Juli; Takayanagi Hiroshi; Penninger Josef M; Matsumoto Mitsuru; Nitta Takeshi; Takahama Yousuke; Inoue Jun-Ichiro
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity 2008;29(3):423-37.
2008: Ban Kiwon; Cooper Andrew J; Samuel Sara; Bhatti Adil; Patel Mikin; Izumo Seigo; Penninger Josef M; Backx Peter H; Oudit Gavin Y; Tsushima Robert G
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning.
Circulation research 2008;103(6):643-53.
2008: Meixner Arabella; Zenz Rainer; Schonthaler Helia B; Kenner Lukas; Scheuch Harald; Penninger Josef M; Wagner Erwin F
Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation.
Nature cell biology 2008;10(8):1003-11.
2008: Hara Hiromitsu; Ishihara Chitose; Takeuchi Arata; Xue Liquan; Morris Stephan W; Penninger Josef M; Yoshida Hiroki; Saito Takashi
Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):918-30.
2008: Galluzzi L; Joza N; Tasdemir E; Maiuri M C; Hengartner M; Abrams J M; Tavernarakis N; Penninger J; Madeo F; Kroemer G
No death without life: vital functions of apoptotic effectors.
Cell death and differentiation 2008;15(7):1113-23.
2008: Joza N; Galindo K; Pospisilik J A; Benit P; Rangachari M; Kanitz E E; Nakashima Y; Neely G G; Rustin P; Abrams J M; Kroemer G; Penninger J M
The molecular archaeology of a mitochondrial death effector: AIF in Drosophila.
Cell death and differentiation 2008;15(6):1009-18.
2008: Oudit Gavin Y; Kassiri Zamaneh; Zhou Joyce; Liu Qiao C; Liu Peter P; Backx Peter H; Dawood Fayez; Crackower Michael A; Scholey James W; Penninger Josef M
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.
Cardiovascular research 2008;78(3):505-14.
2008: Imai Yumiko; Kuba Keiji; Penninger Josef M
The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice.
Experimental physiology 2008;93(5):543-8.
2008: Garabelli Paul J; Modrall J Gregory; Penninger Josef M; Ferrario Carlos M; Chappell Mark C
Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart.
Experimental physiology 2008;93(5):613-21.
2008: Imai Yumiko; Kuba Keiji; Neely G Greg; Yaghubian-Malhami Rubina; Perkmann Thomas; van Loo Geert; Ermolaeva Maria; Veldhuizen Ruud; Leung Y H Connie; Wang Hongliang; Liu Haolin; Sun Yang; Pasparakis Manolis; Kopf Manfred; Mech Christin; Bavari Sina; Peiris J S Malik; Slutsky Arthur S; Akira Shizuo; Hultqvist Malin; Holmdahl Rikard; Nicholls John; Jiang Chengyu; Binder Christoph J; Penninger Josef M
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Cell 2008;133(2):235-49.
2008: Chavakis Emmanouil; Carmona Guillaume; Urbich Carmen; Göttig Stephan; Henschler Reinhard; Penninger Josef M; Zeiher Andreas M; Chavakis Triantafyllos; Dimmeler Stefanie
Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells.
Circulation research 2008;102(8):942-9.
2008: Qiao Guilin; Li Zhenping; Molinero Luciana; Alegre Maria-Luisa; Ying Haiyan; Sun Zuoming; Penninger Josef M; Zhang Jian
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Molecular and cellular biology 2008;28(7):2470-80.
2008: Imai Yumiko; Kuba Keiji; Penninger Josef M
[Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]
Masui. The Japanese journal of anesthesiology 2008;57(3):302-10.
2008: Wada T; Stepniak E; Hui L; Leibbrandt A; Katada T; Nishina H; Wagner E F; Penninger J M
Antagonistic control of cell fates by JNK and p38-MAPK signaling.
Cell death and differentiation 2008;15(1):89-93.
2007: Cronin Shane J F; Penninger Josef M
From T-cell activation signals to signaling control of anti-cancer immunity.
Immunological reviews 2007;220():151-68.
2007: Pospisilik J Andrew; Knauf Claude; Joza Nicholas; Benit Paule; Orthofer Michael; Cani Patrice D; Ebersberger Ingo; Nakashima Tomoki; Sarao Renu; Neely Gregory; Esterbauer Harald; Kozlov Andrey; Kahn C Ronald; Kroemer Guido; Rustin Pierre; Burcelin Remy; Penninger Josef M
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.
Cell 2007;131(3):476-91.
2007: Loeser Stefanie; Penninger Josef M
The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity.
Cell cycle (Georgetown, Tex.) 2007;6(20):2478-85.
2007: Zhang Liyong; Anglesio Michael S; O'Sullivan Maureen; Zhang Fan; Yang Ge; Sarao Renu; Mai P Nghiem; Cronin Shane; Hara Hiromitsu; Melnyk Nataliya; Li Liheng; Wada Teiji; Liu Peter P; Farrar Jason; Arceci Robert J; Sorensen Poul H; Penninger Josef M
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.
Nature medicine 2007;13(9):1060-9.
2007: Tassi Ilaria; Cella Marina; Gilfillan Susan; Turnbull Isaiah; Diacovo Thomas G; Penninger Josef M; Colonna Marco
p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells.
Immunity 2007;27(2):214-27.
2007: Kuba Keiji; Zhang Liyong; Imai Yumiko; Arab Sara; Chen Manyin; Maekawa Yuichiro; Leschnik Michael; Leibbrandt Andreas; Markovic Mato; Schwaighofer Julia; Beetz Nadine; Musialek Renata; Neely G Greg; Komnenovic Vukoslav; Kolm Ursula; Metzler Bernhard; Ricci Romeo; Hara Hiromitsu; Meixner Arabella; Nghiem Mai; Chen Xin; Dawood Fayez; Wong Kit Man; Sarao Renu; Cukerman Eva; Kimura Akinori; Hein Lutz; Thalhammer Johann; Liu Peter P; Penninger Josef M
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.
Circulation research 2007;101(4):e32-42.
2007: Wong Denise W; Oudit Gavin Y; Reich Heather; Kassiri Zamaneh; Zhou Joyce; Liu Qiao C; Backx Peter H; Penninger Josef M; Herzenberg Andrew M; Scholey James W
Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.
The American journal of pathology 2007;171(2):438-51.
2007: Imai Y; Kuba K; Penninger J M
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Cellular and molecular life sciences : CMLS 2007;64(15):2006-12.
2007: Liu Lixin; Puri Kamal D; Penninger Josef M; Kubes Paul
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo.
Blood 2007;110(4):1191-8.
2007: Oudit Gavin Y; Kassiri Zamaneh; Patel Mikin P; Chappell Mark; Butany Jagdish; Backx Peter H; Tsushima Robert G; Scholey James W; Khokha Rama; Penninger Josef M
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.
Cardiovascular research 2007;75(1):29-39.
2007: Rossi Simona W; Kim Mi-Yeon; Leibbrandt Andreas; Parnell Sonia M; Jenkinson William E; Glanville Stephanie H; McConnell Fiona M; Scott Hamish S; Penninger Josef M; Jenkinson Eric J; Lane Peter J L; Anderson Graham
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine 2007;204(6):1267-72.
2007: Hara Hiromitsu; Ishihara Chitose; Takeuchi Arata; Imanishi Takayuki; Xue Liquan; Morris Stephan W; Inui Masanori; Takai Toshiyuki; Shibuya Akira; Saijo Shinobu; Iwakura Yoichiro; Ohno Naohito; Koseki Haruhiko; Yoshida Hiroki; Penninger Josef M; Saito Takashi
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Nature immunology 2007;8(6):619-29.
2007: Zuber Annie Mercier; Singer Dustin; Penninger Josef M; Rossier Bernard C; Firsov Dmitri
Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice.
Journal of the American Society of Nephrology : JASN 2007;18(6):1672-8.
2007: Loeser Stefanie; Penninger Josef M
Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b.
Seminars in immunology 2007;19(3):206-14.
2007: Alnaeeli Mawadda; Park Jaekweon; Mahamed Deeqa; Penninger Joseph M; Teng Yen-Tung A
Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(6):775-80.
2007: Loeser Stefanie; Loser Karin; Bijker Martijn S; Rangachari Manu; van der Burg Sjoerd H; Wada Teiji; Beissert Stefan; Melief Cornelis J M; Penninger Josef M
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.
The Journal of experimental medicine 2007;204(4):879-91.
2007: Shambharkar Prashant B; Blonska Marzenna; Pappu Bhanu P; Li Hongxiu; You Yun; Sakurai Hiroaki; Darnay Bryant G; Hara Hiromitsu; Penninger Josef; Lin Xin
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
The EMBO journal 2007;26(7):1794-805.
2007: Séverin Sonia; Gratacap Marie-Pierre; Lenain Nadège; Alvarez Laetitia; Hollande Etienne; Penninger Josef M; Gachet Christian; Plantavid Monique; Payrastre Bernard
Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth.
The Journal of clinical investigation 2007;117(4):944-52.
2007: Fischer L; Gukovskaya A S; Penninger J M; Mareninova O A; Friess H; Gukovsky I; Pandol S J
Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(3):G875-86.
2007: Feraud O; Debili N; Penninger J M; Kroemer G
Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF.
Cell death and differentiation 2007;14(2):385-7.
2007: Nakamichi Yuko; Udagawa Nobuyuki; Kobayashi Yasuhiro; Nakamura Midrori; Yamamoto Yohei; Yamashita Teruhito; Mizoguchi Toshihide; Sato Masahiro; Mogi Makio; Penninger Josef M; Takahashi Naoyuki
Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):192-200.
2007: Nishio Miki; Watanabe Ken-ichi; Sasaki Junko; Taya Choji; Takasuga Shunsuke; Iizuka Ryota; Balla Tamas; Yamazaki Masakazu; Watanabe Hiroshi; Itoh Reietsu; Kuroda Shoko; Horie Yasuo; Förster Irmgard; Mak Tak W; Yonekawa Hiromichi; Penninger Josef M; Kanaho Yasunori; Suzuki Akira; Sasaki Takehiko
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.
Nature cell biology 2007;9(1):36-44.
2006: Danilczyk Ursula; Sarao Renu; Remy Christine; Benabbas Chahira; Stange Gerti; Richter Andreas; Arya Sudha; Pospisilik J Andrew; Singer Dustin; Camargo Simone M R; Makrides Victoria; Ramadan Tamara; Verrey Francois; Wagner Carsten A; Penninger Josef M
Essential role for collectrin in renal amino acid transport.
Nature 2006;444(7122):1088-91.
2006: Cheng Hai-Ying M; Dziema Heather; Papp Joseph; Mathur Daniel P; Koletar Margaret; Ralph Martin R; Penninger Josef M; Obrietan Karl
The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(50):12984-95.
2006: Loser Karin; Mehling Annette; Loeser Stefanie; Apelt Jenny; Kuhn Annegret; Grabbe Stephan; Schwarz Thomas; Penninger Josef M; Beissert Stefan
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells.
Nature medicine 2006;12(12):1372-9.
2006: Kuba Keiji; Imai Yumiko; Rao Shuan; Jiang Chengyu; Penninger Josef M
Lessons from SARS: control of acute lung failure by the SARS receptor ACE2.
Journal of molecular medicine (Berlin, Germany) 2006;84(10):814-20.
2006: Roy Anju Anne; Nunn Caroline; Ming Hong; Zou Min-Xu; Penninger Josef; Kirshenbaum Lorrie A; Dixon S Jeffrey; Chidiac Peter
Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.
The Journal of biological chemistry 2006;281(43):32684-93.
2006: Maruyama Kenta; Takada Yasunari; Ray Neelanjan; Kishimoto Yukiko; Penninger Josef M; Yasuda Hisataka; Matsuo Koichi
Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3799-805.
2006: Alnaeeli Mawadda; Penninger Josef M; Teng Yen-Tung Andy
Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3314-26.
2006: Cheung Eric C C; Joza Nicholas; Steenaart Nancy A E; McClellan Kelly A; Neuspiel Margaret; McNamara Stephen; MacLaurin Jason G; Rippstein Peter; Park David S; Shore Gordon C; McBride Heidi M; Penninger Josef M; Slack Ruth S
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.
The EMBO journal 2006;25(17):4061-73.
2006: Rangachari Manu; Mauermann Nora; Marty René R; Dirnhofer Stephan; Kurrer Michael O; Komnenovic Vukoslav; Penninger Josef M; Eriksson Urs
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.
The Journal of experimental medicine 2006;203(8):2009-19.
2006: Zhao Min; Song Bing; Pu Jin; Wada Teiji; Reid Brian; Tai Guangping; Wang Fei; Guo Aihua; Walczysko Petr; Gu Yu; Sasaki Takehiko; Suzuki Akira; Forrester John V; Bourne Henry R; Devreotes Peter N; McCaig Colin D; Penninger Josef M
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.
Nature 2006;442(7101):457-60.
2006: Yamamoto Yohei; Udagawa Nobuyuki; Matsuura Sachiko; Nakamichi Yuko; Horiuchi Hiroshi; Hosoya Akihiro; Nakamura Midori; Ozawa Hidehiro; Takaoka Kunio; Penninger Josef M; Noguchi Toshihide; Takahashi Naoyuki
Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand.
Endocrinology 2006;147(7):3366-74.
2006: Brown Doris; Yu Benjamin D; Joza Nicholas; Bénit Paule; Meneses Juanito; Firpo Meri; Rustin Pierre; Penninger Josef M; Martin Gail R
Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9918-23.
2006: Oudit Gavin Y; Herzenberg Andrew M; Kassiri Zamaneh; Wong Denise; Reich Heather; Khokha Rama; Crackower Michael A; Backx Peter H; Penninger Josef M; Scholey James W
Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis.
The American journal of pathology 2006;168(6):1808-20.
2006: Vorbach Claudia; Capecchi Mario R; Penninger Josef M
Evolution of the mammary gland from the innate immune system?
BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(6):606-16.
2006: Sun Hui; Kerfant Benoit-Gilles; Zhao Dongling; Trivieri Maria G; Oudit Gavin Y; Penninger Josef M; Backx Peter H
Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling.
Circulation research 2006;98(11):1390-7.
2006: Kuba Keiji; Imai Yumiko; Penninger Josef M
Angiotensin-converting enzyme 2 in lung diseases.
Current opinion in pharmacology 2006;6(3):271-6.
2006: Jones D Holstead; Nakashima Tomoki; Sanchez Otto H; Kozieradzki Ivona; Komarova Svetlana V; Sarosi Ildiko; Morony Sean; Rubin Evelyn; Sarao Renu; Hojilla Carlo V; Komnenovic Vukoslav; Kong Young-Yun; Schreiber Martin; Dixon S Jeffrey; Sims Stephen M; Khokha Rama; Wada Teiji; Penninger Josef M
Regulation of cancer cell migration and bone metastasis by RANKL.
Nature 2006;440(7084):692-6.
2006: Danilczyk Ursula; Penninger Josef M
Angiotensin-converting enzyme II in the heart and the kidney.
Circulation research 2006;98(4):463-71.
2006: Kim Nam-Shik; Kim Hyun-Ju; Koo Bon-Kyoung; Kwon Min-Chul; Kim Young-Woong; Cho Yunje; Yokota Yoshifumi; Penninger Josef M; Kong Young-Yun
Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2.
Molecular and cellular biology 2006;26(3):1002-13.
2006: Valdés G; Neves L A A; Anton L; Corthorn J; Chacón C; Germain A M; Merrill D C; Ferrario C M; Sarao R; Penninger J; Brosnihan K B
Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies.
Placenta 2006;27(2-3):200-7.
2006: Marty René R; Dirnhofer Stephan; Mauermann Nora; Schweikert Sacha; Akira Shizuo; Hunziker Lukas; Penninger Josef M; Eriksson Urs
MyD88 signaling controls autoimmune myocarditis induction.
Circulation 2006;113(2):258-65.
2006: Wada Teiji; Nakashima Tomoki; Hiroshi Nishina; Penninger Josef M
RANKL-RANK signaling in osteoclastogenesis and bone disease.
Trends in molecular medicine 2006;12(1):17-25.
2005: Liu Yun-Cai; Penninger Josef; Karin Michael
Immunity by ubiquitylation: a reversible process of modification.
Nature reviews. Immunology 2005;5(12):941-52.
2005: Joza Nicholas; Oudit Gavin Y; Brown Doris; Bénit Paule; Kassiri Zamaneh; Vahsen Nicola; Benoit Loralyn; Patel Mikin M; Nowikovsky Karin; Vassault Anne; Backx Peter H; Wada Teiji; Kroemer Guido; Rustin Pierre; Penninger Josef M
Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy.
Molecular and cellular biology 2005;25(23):10261-72.
2005: Kuba Keiji; Imai Yumiko; Rao Shuan; Gao Hong; Guo Feng; Guan Bin; Huan Yi; Yang Peng; Zhang Yanli; Deng Wei; Bao Linlin; Zhang Binlin; Liu Guang; Wang Zhong; Chappell Mark; Liu Yanxin; Zheng Dexian; Leibbrandt Andreas; Wada Teiji; Slutsky Arthur S; Liu Depei; Qin Chuan; Jiang Chengyu; Penninger Josef M
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Nature medicine 2005;11(8):875-9.
2005: Imai Yumiko; Kuba Keiji; Rao Shuan; Huan Yi; Guo Feng; Guan Bin; Yang Peng; Sarao Renu; Wada Teiji; Leong-Poi Howard; Crackower Michael A; Fukamizu Akiyoshi; Hui Chi-Chung; Hein Lutz; Uhlig Stefan; Slutsky Arthur S; Jiang Chengyu; Penninger Josef M
Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Nature 2005;436(7047):112-6.
2005: Kolas Nadine K; Marcon Edyta; Crackower Michael A; Höög Christer; Penninger Josef M; Spyropoulos Barbara; Moens Peter B
Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility.
Chromosoma 2005;114(2):92-102.
2005: Puri Kamal D; Doggett Teresa A; Huang Ching-Yu; Douangpanya Jason; Hayflick Joel S; Turner Martin; Penninger Josef; Diacovo Thomas G
The role of endothelial PI3Kgamma activity in neutrophil trafficking.
Blood 2005;106(1):150-7.
2005: Kerfant Benoit-Gilles; Gidrewicz Dominica; Sun Hui; Oudit Gavin Y; Penninger Josef M; Backx Peter H
Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice.
Circulation research 2005;96(10):1079-86.
2005: Mahamed Deeqa A; Marleau Annette; Alnaeeli Mawadda; Singh Bhagirath; Zhang Xiaoxia; Penninger Joseph M; Teng Yen-Tung A
G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice.
Diabetes 2005;54(5):1477-86.
2005: Wang Xinhua; Zeng Weizhong; Soyombo Abigail A; Tang Wei; Ross Elliott M; Barnes Anthony P; Milgram Sharon L; Penninger Josef M; Allen Patrick B; Greengard Paul; Muallem Shmuel
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors.
Nature cell biology 2005;7(4):405-11.
2005: Wada Teiji; Nakashima Tomoki; Oliveira-dos-Santos Antonio J; Gasser Juerg; Hara Hiromitsu; Schett Georg; Penninger Josef M
The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.
Nature medicine 2005;11(4):394-9.
2005: Sasaki Junko; Sasaki Takehiko; Yamazaki Masakazu; Matsuoka Kunie; Taya Choji; Shitara Hiroshi; Takasuga Shunsuke; Nishio Miki; Mizuno Katsunori; Wada Teiji; Miyazaki Hideyuki; Watanabe Hiroshi; Iizuka Ryota; Kubo Shuichi; Murata Shigeo; Chiba Tomoki; Maehama Tomohiko; Hamada Koichi; Kishimoto Hiroyuki; Frohman Michael A; Tanaka Keiji; Penninger Josef M; Yonekawa Hiromichi; Suzuki Akira; Kanaho Yasunori
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.
The Journal of experimental medicine 2005;201(6):859-70.
2005: Krawczyk Connie M; Jones Russell G; Atfield Alexandre; Bachmaier Kurt; Arya Sudha; Odermatt Bernhard; Ohashi Pamela S; Penninger Josef M
Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1472-8.
2005: Ricci Romeo; Eriksson Urs; Oudit Gavin Y; Eferl Robert; Akhmedov Alexander; Sumara Izabela; Sumara Grzegorz; Kassiri Zamaneh; David Jean-Pierre; Bakiri Latifa; Sasse Bernd; Idarraga Maria-Helena; Rath Martina; Kurz David; Theussl Hans-Christian; Perriard Jean-Claude; Backx Peter; Penninger Josef M; Wagner Erwin F
Distinct functions of junD in cardiac hypertrophy and heart failure.
Genes & development 2005;19(2):208-13.
2005: Eriksson Urs; Penninger Josef M
Autoimmune heart failure: new understandings of pathogenesis.
The international journal of biochemistry & cell biology 2005;37(1):27-32.
2005: Bachmaier K; Penninger J M
Chlamydia and antigenic mimicry.
Current topics in microbiology and immunology 2005;296():153-63.
2004: Fischer L; Gukovskaya A S; Young S H; Gukovsky I; Lugea A; Buechler P; Penninger J M; Friess H; Pandol S J
Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(6):G1200-12.
2004: Danilczyk U; Eriksson U; Oudit G Y; Penninger J M
Physiological roles of angiotensin-converting enzyme 2.
Cellular and molecular life sciences : CMLS 2004;61(21):2714-9.
2004: Vahsen Nicola; Candé Céline; Brière Jean-Jacques; Bénit Paule; Joza Nicholas; Larochette Nathanael; Mastroberardino Pier Giorgio; Pequignot Marie O; Casares Noelia; Lazar Vladimir; Feraud Olivier; Debili Najet; Wissing Silke; Engelhardt Silvia; Madeo Frank; Piacentini Mauro; Penninger Josef M; Schägger Hermann; Rustin Pierre; Kroemer Guido
AIF deficiency compromises oxidative phosphorylation.
The EMBO journal 2004;23(23):4679-89.
2004: Martin-McCaffrey Luke; Willard Francis S; Oliveira-dos-Santos Antonio J; Natale David R C; Snow Bryan E; Kimple Randall J; Pajak Agnieszka; Watson Andrew J; Dagnino Lina; Penninger Josef M; Siderovski David P; D'Souza Sudhir J A
RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote.
Developmental cell 2004;7(5):763-9.
2004: Hara Hiromitsu; Bakal Christopher; Wada Teiji; Bouchard Denis; Rottapel Robert; Saito Takashi; Penninger Josef M
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse.
The Journal of experimental medicine 2004;200(9):1167-77.
2004: Danilczyk Ursula; Penninger Josef
Hypertension with a grain of salt.
Nature medicine 2004;10(11):1163-4.
2004: Cheng H-Y M; Penninger J M
DREAMing about arthritic pain.
Annals of the rheumatic diseases 2004;63 Suppl 2():ii72-ii75.
2004: Gronski Matthew A; Boulter Jonathan M; Moskophidis Demetrius; Nguyen Linh T; Holmberg Kaisa; Elford Alisha R; Deenick Elissa K; Kim Hee O; Penninger Josef M; Odermatt Bernhard; Gallimore Awen; Gascoigne Nicholas R J; Ohashi Pamela S
TCR affinity and negative regulation limit autoimmunity.
Nature medicine 2004;10(11):1234-9.
2004: Matsumoto Goichi; Kubota Eiro; Omi Yasushi; Lee Ushaku; Penninger Josef M
Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4976-84.
2004: Wang Xinhua; Huang Guojin; Luo Xiang; Penninger Josef M; Muallem Shmuel
Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells.
The Journal of biological chemistry 2004;279(40):41642-9.
2004: Cheng Hai-Ying M; Obrietan Karl; Cain Sean W; Lee Bo Young; Agostino Patricia V; Joza Nicholas A; Harrington Mary E; Ralph Martin R; Penninger Josef M
Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock.
Neuron 2004;43(5):715-28.
2004: Anglesio Michael S; Evdokimova Valentina; Melnyk Nataliya; Zhang Liyong; Fernandez Conrad V; Grundy Paul E; Leach Stephen; Marra Marco A; Brooks-Wilson Angela R; Penninger Josef; Sorensen Poul H B
Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.
Human molecular genetics 2004;13(18):2061-74.
2004: Jeon Myung-Shin; Atfield Alex; Venuprasad K; Krawczyk Connie; Sarao Renu; Elly Chris; Yang Chun; Arya Sudha; Bachmaier Kurt; Su Leon; Bouchard Dennis; Jones Russel; Gronski Mathew; Ohashi Pamela; Wada Teiji; Bloom Debra; Fathman C Garrison; Liu Yun-Cai; Penninger Josef M
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.
Immunity 2004;21(2):167-77.
2004: Reif Karin; Okkenhaug Klaus; Sasaki Takehiko; Penninger Joseph M; Vanhaesebroeck Bart; Cyster Jason G
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2236-40.
2004: Oudit Gavin Y; Sun Hui; Kerfant Benoit-Gilles; Crackower Michael A; Penninger Josef M; Backx Peter H
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease.
Journal of molecular and cellular cardiology 2004;37(2):449-71.
2004: Rangachari Manu; Penninger Josef M
Negative regulation of T cell receptor signals.
Current opinion in pharmacology 2004;4(4):415-22.
2004: Cheng Hai-Ying M; Laviolette Steven R; van der Kooy Derek; Penninger Josef M
DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine.
The European journal of neuroscience 2004;19(11):3033-41.
2004: Wada Teiji; Penninger Josef M
Stress kinase MKK7: savior of cell cycle arrest and cellular senescence.
Cell cycle (Georgetown, Tex.) 2004;3(5):577-9.
2004: Wada Teiji; Penninger Josef M
Mitogen-activated protein kinases in apoptosis regulation.
Oncogene 2004;23(16):2838-49.
2004: Wada Teiji; Joza Nicholas; Cheng Hai-ying M; Sasaki Takehiko; Kozieradzki Ivona; Bachmaier Kurt; Katada Toshiaki; Schreiber Martin; Wagner Erwin F; Nishina Hiroshi; Penninger Josef M
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Nature cell biology 2004;6(3):215-26.
2004: Perfettini Jean-Luc; Roumier Thomas; Castedo Maria; Larochette Nathanael; Boya Patricia; Raynal Brigitte; Lazar Vladimir; Ciccosanti Fabiola; Nardacci Roberta; Penninger Josef; Piacentini Mauro; Kroemer Guido
NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope.
The Journal of experimental medicine 2004;199(5):629-40.
2004: Gukovsky Ilya; Cheng Jason H; Nam Kyung J; Lee Oliver T; Lugea Aurelia; Fischer Lars; Penninger Josef M; Pandol Stephen J; Gukovskaya Anna S
Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells.
Gastroenterology 2004;126(2):554-66.
2004: Candé Céline; Vahsen Nicola; Kouranti Ilektra; Schmitt Elise; Daugas Eric; Spahr Chris; Luban Jeremy; Kroemer Romano T; Giordanetto Fabrizio; Garrido Carmen; Penninger Josef M; Kroemer Guido
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis.
Oncogene 2004;23(8):1514-21.
2004: Marra Luciano E; Zhang Zhu X; Joe Betty; Campbell Jon; Levy Gary A; Penninger Josef; Zhang Li
IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1028-35.
2004: Nishitai Gen; Shimizu Nao; Negishi Takahiro; Kishimoto Hiroyuki; Nakagawa Kentaro; Kitagawa Daiju; Watanabe Tomomi; Momose Haruka; Ohata Shinya; Tanemura Shuhei; Asaka Satoshi; Kubota Junko; Saito Ryota; Yoshida Hiroki; Mak Tak W; Wada Teiji; Penninger Josef M; Azuma Noriyuki; Nishina Hiroshi; Katada Toshiaki
Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.
The Journal of biological chemistry 2004;279(3):1621-6.
2003: Schmitt Elise; Parcellier Arnaud; Gurbuxani Sandeep; Cande Celine; Hammann Arlette; Morales Maria Celia; Hunt Clayton R; Dix David J; Kroemer Romano T; Giordanetto Fabrizio; Jäättelä Marja; Penninger Josef M; Pance Alena; Kroemer Guido; Garrido Carmen
Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.
Cancer research 2003;63(23):8233-40.
2003: Suzuki Nobutaka; Suzuki Shinobu; Eriksson Urs; Hara Hiromitsu; Mirtosis Christine; Chen Nien-Jung; Wada Teiji; Bouchard Denis; Hwang Irene; Takeda Kiyoshi; Fujita Takashi; Der Sandy; Penninger Josef M; Akira Shizuo; Saito Takashi; Yeh Wen-Chen
IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6065-71.
2003: Eriksson Urs; Ricci Romeo; Hunziker Lukas; Kurrer Michael O; Oudit Gavin Y; Watts Tania H; Sonderegger Ivo; Bachmaier Kurt; Kopf Manfred; Penninger Josef M
Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity.
Nature medicine 2003;9(12):1484-90.
2003: Griffiths Emily K; Sanchez Otto; Mill Pleasantine; Krawczyk Connie; Hojilla Carlo V; Rubin Evelyn; Nau Marion M; Khokha Rama; Lipkowitz Stan; Hui Chi-Chung; Penninger Josef M
Cbl-3-deficient mice exhibit normal epithelial development.
Molecular and cellular biology 2003;23(21):7708-18.
2003: Kim Chaekyun; Marchal Christophe C; Penninger Josef; Dinauer Mary C
The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4425-30.
2003: Oudit Gavin Y; Crackower Michael A; Eriksson Urs; Sarao Renu; Kozieradzki Ivona; Sasaki Takehiko; Irie-Sasaki Junko; Gidrewicz Dominica; Rybin Vitalyi O; Wada Teiji; Steinberg Susan F; Backx Peter H; Penninger Josef M
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Circulation 2003;108(17):2147-52.
2003: Brosnihan K Bridget; Neves Liomar A A; Joyner JaNae; Averill David B; Chappell Mark C; Sarao Renu; Penninger Josef; Ferrario Carlos M
Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy.
Hypertension 2003;42(4):749-53.
2003: Hara Hiromitsu; Wada Teiji; Bakal Chris; Kozieradzki Ivona; Suzuki Shinobu; Suzuki Nobutaka; Nghiem Mai; Griffiths Emily K; Krawczyk Connie; Bauer Birgit; D'Acquisto Fulvio; Ghosh Sankar; Yeh Wen Chen; Baier Gottfried; Rottapel Robert; Penninger Josef M
The MAGUK family protein CARD11 is essential for lymphocyte activation.
Immunity 2003;18(6):763-75.
2003: Jun Jesse E; Wilson Lauren E; Vinuesa Carola G; Lesage Sylvie; Blery Mathieu; Miosge Lisa A; Cook Matthew C; Kucharska Edyta M; Hara Hiromitsu; Penninger Josef M; Domashenz Heather; Hong Nancy A; Glynne Richard J; Nelms Keats A; Goodnow Christopher C
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.
Immunity 2003;18(6):751-62.
2003: Gonzalez-Espinosa Claudia; Odom Sandra; Olivera Ana; Hobson J Peyton; Martinez Maria Eugenia Cid; Oliveira-Dos-Santos Antonio; Barra Lillian; Spiegel Sarah; Penninger Josef M; Rivera Juan
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.
The Journal of experimental medicine 2003;197(11):1453-65.
2003: Crackower Michael A; Kolas Nadine K; Noguchi Junko; Sarao Renu; Kikuchi Kazuhiro; Kaneko Hiroyuki; Kobayashi Eiji; Kawai Yasuhiro; Kozieradzki Ivona; Landers Rushin; Mo Rong; Hui Chi-Chung; Nieves Edward; Cohen Paula E; Osborne Lucy R; Wada Teiji; Kunieda Tetsuo; Moens Peter B; Penninger Josef M
Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.
Science (New York, N.Y.) 2003;300(5623):1291-5.
2003: Nakashima Tomoki; Wada Teiji; Penninger Josef M
RANKL and RANK as novel therapeutic targets for arthritis.
Current opinion in rheumatology 2003;15(3):280-7.
2003: Kishimoto Hiroyuki; Nakagawa Kentaro; Watanabe Tomomi; Kitagawa Daiju; Momose Haruka; Seo Jungwon; Nishitai Gen; Shimizu Nao; Ohata Shinya; Tanemura Shuhei; Asaka Satoshi; Goto Takayuki; Fukushi Hiromichi; Yoshida Hiroki; Suzuki Akira; Sasaki Takehiko; Wada Teiji; Penninger Josef M; Nishina Hiroshi; Katada Toshiaki
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.
The Journal of biological chemistry 2003;278(19):16595-601.
2003: Danilczyk Ursula; Eriksson Urs; Crackower Michael A; Penninger Josef M
A story of two ACEs.
Journal of molecular medicine (Berlin, Germany) 2003;81(4):227-34.
2003: Heximer Scott P; Knutsen Russell H; Sun Xiaoguang; Kaltenbronn Kevin M; Rhee Man-Hee; Peng Ning; Oliveira-dos-Santos Antonio; Penninger Josef M; Muslin Anthony J; Steinberg Thomas H; Wyss J Michael; Mecham Robert P; Blumer Kendall J
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
The Journal of clinical investigation 2003;111(8):1259.
2003: Oudit Gavin Y; Crackower Michael A; Backx Peter H; Penninger Josef M
The role of ACE2 in cardiovascular physiology.
Trends in cardiovascular medicine 2003;13(3):93-101.
2003: Suzuki Nobutaka; Chen Nien-Jung; Millar Douglas G; Suzuki Shinobu; Horacek Thomas; Hara Hiromitsu; Bouchard Denis; Nakanishi Kenji; Penninger Josef M; Ohashi Pamela S; Yeh Wen-Chen
IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4031-5.
2003: Cheng Hai-Ying M; Penninger Josef M
When the DREAM is gone: from basic science to future prospectives in pain management and beyond.
Expert opinion on therapeutic targets 2003;7(2):249-63.
2003: Saibil Samuel D; Ohteki Toshiaki; White Forest M; Luscher Mark; Zakarian Arsen; Elford Alisha; Shabanowitz Jeffery; Nishina Hiroshi; Hugo Patrice; Penninger Josef; Barber Brian; Hunt Donald F; Ohashi Pamela S
Weak agonist self-peptides promote selection and tuning of virus-specific T cells.
European journal of immunology 2003;33(3):685-96.
2003: Heximer Scott P; Knutsen Russell H; Sun Xiaoguang; Kaltenbronn Kevin M; Rhee Man-Hee; Peng Ning; Oliveira-dos-Santos Antonio; Penninger Josef M; Muslin Anthony J; Steinberg Thomas H; Wyss J Michael; Mecham Robert P; Blumer Kendall J
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
The Journal of clinical investigation 2003;111(4):445-52.
2003: Eriksson Urs; Kurrer Michael O; Sonderegger Ivo; Iezzi Giandomenica; Tafuri Anna; Hunziker Lukas; Suzuki Shinobu; Bachmaier Kurt; Bingisser Roland M; Penninger Josef M; Kopf Manfred
Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis.
The Journal of experimental medicine 2003;197(3):323-31.
2003: Penninger Josef M; Kroemer Guido
Mitochondria, AIF and caspases--rivaling for cell death execution.
Nature cell biology 2003;5(2):97-9.
2003: Irie-Sasaki Junko; Sasaki Takehiko; Penninger Josef M
CD45 regulated signaling pathways.
Current topics in medicinal chemistry 2003;3(7):783-96.
2002: Matsumoto Goichi; Tsunematsu Satoshi; Tsukinoki Kei-ichi; Ohmi Yasushi; Iwamiya Mariko; Oliveira-dos-Santos Antonio; Tone Daisuke; Shindo Junichi; Penninger Josef M
Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):7087-96.
2002: Roumier T; Vieira H L A; Castedo M; Ferri K F; Boya P; Andreau K; Druillennec S; Joza N; Penninger J M; Roques B; Kroemer G
The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway.
Cell death and differentiation 2002;9(11):1212-9.
2002: Jones D Holstead; Kong Y-Y; Penninger J M
Role of RANKL and RANK in bone loss and arthritis.
Annals of the rheumatic diseases 2002;61 Suppl 2():ii32-9.
2002: Ito Nobuko; Yokomizo Takehiko; Sasaki Takehiko; Kurosu Hiroshi; Penninger Josef; Kanaho Yasunori; Katada Toshiaki; Hanaoka Kazuo; Shimizu Takao
Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.
The Journal of biological chemistry 2002;277(47):44898-904.
2002: Eriksson Urs; Danilczyk Ursula; Penninger Josef M
Just the beginning: novel functions for angiotensin-converting enzymes.
Current biology : CB 2002;12(21):R745-52.
2002: Watanabe Tomomi; Nakagawa Kentaro; Ohata Shinya; Kitagawa Daiju; Nishitai Gen; Seo Jungwon; Tanemura Shuhei; Shimizu Nao; Kishimoto Hiroyuki; Wada Teiji; Aoki Junken; Arai Hiroyuki; Iwatsubo Takeshi; Mochita Miyuki; Watanabe Toshio; Satake Masanobu; Ito Yoshiaki; Matsuyama Toshifumi; Mak Tak W; Penninger Josef M; Nishina Hiroshi; Katada Toshiaki
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Developmental biology 2002;250(2):332-47.
2002: Cheng Hai-Ying M; Penninger Josef M
Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management?
Expert review of neurotherapeutics 2002;2(5):677-89.
2002: Crackower Michael A; Oudit Gavin Y; Kozieradzki Ivona; Sarao Renu; Sun Hui; Sasaki Takehiko; Hirsch Emilio; Suzuki Akira; Shioi Tetsuo; Irie-Sasaki Junko; Sah Rajan; Cheng Hai-Ying M; Rybin Vitalyi O; Lembo Giuseppe; Fratta Luigi; Oliveira-dos-Santos Antonio J; Benovic Jeffery L; Kahn C Ronald; Izumo Seigo; Steinberg Susan F; Wymann Matthias P; Backx Peter H; Penninger Josef M
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Crackower Michael A; Sarao Renu; Oudit Gavin Y; Yagil Chana; Kozieradzki Ivona; Scanga Sam E; Oliveira-dos-Santos Antonio J; da Costa Joan; Zhang Liyong; Pei York; Scholey James; Ferrario Carlos M; Manoukian Armen S; Chappell Mark C; Backx Peter H; Yagil Yoram; Penninger Josef M
Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Nature 2002;417(6891):822-8.
2002: Opavsky Mary Anne; Martino Tami; Rabinovitch Marlene; Penninger Josef; Richardson Chris; Petric Martin; Trinidad Cathy; Butcher Lisa; Chan Janice; Liu Peter P
Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis.
The Journal of clinical investigation 2002;109(12):1561-9.
2002: Griffiths Emily K; Penninger Josef M
Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap.
Current opinion in immunology 2002;14(3):317-22.
2002: Maté María J; Ortiz-Lombardía Miguel; Boitel Brigitte; Haouz Ahmed; Tello Diana; Susin Santos A; Penninger Josef; Kroemer Guido; Alzari Pedro M
The crystal structure of the mouse apoptosis-inducing factor AIF.
Nature structural biology 2002;9(6):442-6.
2002: Griffiths Emily K; Penninger Josef M
ADAP-ting TCR signaling to integrins.
Science's STKE : signal transduction knowledge environment 2002;2002(127):re3.
2002: Sasaki Takehiko; Suzuki Akira; Sasaki Junko; Penninger Josef M
Phosphoinositide 3-kinases in immunity: lessons from knockout mice.
Journal of biochemistry 2002;131(4):495-501.
2002: Suzuki Nobutaka; Suzuki Shinobu; Duncan Gordon S; Millar Douglas G; Wada Teiji; Mirtsos Christine; Takada Hidetoshi; Wakeham Andrew; Itie Annick; Li Shyun; Penninger Josef M; Wesche Holger; Ohashi Pamela S; Mak Tak W; Yeh Wen-Chen
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Nature 2002;416(6882):750-6.
2002: Krawczyk Connie; Oliveira-dos-Santos Antonio; Sasaki Takehiko; Griffiths Emily; Ohashi Pamela S; Snapper Scott; Alt Fred; Penninger Josef M
Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.
Immunity 2002;16(3):331-43.
2002: Joza Nicholas; Kroemer Guido; Penninger Josef M
Genetic analysis of the mammalian cell death machinery.
Trends in genetics : TIG 2002;18(3):142-9.
2002: Kim Hyun-Ju; Yoon Mi-Jeong; Lee Jinie; Penninger Josef M; Kong Young-Yun
Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta.
The Journal of biological chemistry 2002;277(7):5339-44.
2002: Cheng Hai-Ying M; Pitcher Graham M; Laviolette Steven R; Whishaw Ian Q; Tong Kit I; Kockeritz Lisa K; Wada Teiji; Joza Nicholas A; Crackower Michael; Goncalves Jason; Sarosi Ildiko; Woodgett James R; Oliveira-dos-Santos Antonio J; Ikura Mitsuhiko; van der Kooy Derek; Salter Michael W; Penninger Josef M
DREAM is a critical transcriptional repressor for pain modulation.
Cell 2002;108(1):31-43.
2002: Theill Lars E; Boyle William J; Penninger Josef M
RANK-L and RANK: T cells, bone loss, and mammalian evolution.
Annual review of immunology 2002;20():795-823.
2001: Sasaki T; Sasaki-Irie J; Penninger J M
New insights into the transmembrane protein tyrosine phosphatase CD45.
The international journal of biochemistry & cell biology 2001;33(11):1041-6.
2001: Griffiths E K; Krawczyk C; Kong Y Y; Raab M; Hyduk S J; Bouchard D; Chan V S; Kozieradzki I; Oliveira-Dos-Santos A J; Wakeham A; Ohashi P S; Cybulsky M I; Rudd C E; Penninger J M
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Science (New York, N.Y.) 2001;293(5538):2260-3.
2001: Sasaki T; Wada T; Kishimoto H; Irie-Sasaki J; Matsumoto G; Goto T; Yao Z; Wakeham A; Mak T W; Suzuki A; Cho S K; Zuniga-Pflucker J C; Oliveira-dos-Santos A J; Katada T; Nishina H; Penninger J M
The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.
The Journal of experimental medicine 2001;194(6):757-68.
2001: Sasaki T; Sasaki J; Suzuki A; Penninger J M
[Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2001;46(12):1820-9.
2001: Ravagnan L; Gurbuxani S; Susin S A; Maisse C; Daugas E; Zamzami N; Mak T; Jäättelä M; Penninger J M; Garrido C; Kroemer G
Heat-shock protein 70 antagonizes apoptosis-inducing factor.
Nature cell biology 2001;3(9):839-43.
2001: Wada T; Nakagawa K; Watanabe T; Nishitai G; Seo J; Kishimoto H; Kitagawa D; Sasaki T; Penninger J M; Nishina H; Katada T
Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation.
The Journal of biological chemistry 2001;276(33):30892-7.
2001: Penninger J M; Irie-Sasaki J; Sasaki T; Oliveira-dos-Santos A J
CD45: new jobs for an old acquaintance.
Nature immunology 2001;2(5):389-96.
2001: Krawczyk C; Penninger J M
Molecular controls of antigen receptor clustering and autoimmunity.
Trends in cell biology 2001;11(5):212-20.
2001: Miramar M D; Costantini P; Ravagnan L; Saraiva L M; Haouzi D; Brothers G; Penninger J M; Peleato M L; Kroemer G; Susin S A
NADH oxidase activity of mitochondrial apoptosis-inducing factor.
The Journal of biological chemistry 2001;276(19):16391-8.
2001: Joza N; Susin S A; Daugas E; Stanford W L; Cho S K; Li C Y; Sasaki T; Elia A J; Cheng H Y; Ravagnan L; Ferri K F; Zamzami N; Wakeham A; Hakem R; Yoshida H; Kong Y Y; Mak T W; Zúñiga-Pflücker J C; Kroemer G; Penninger J M
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.
Nature 2001;410(6828):549-54.
2001: Krawczyk C; Penninger J M
Molecular motors involved in T cell receptor clusterings.
Journal of leukocyte biology 2001;69(3):317-30.
2001: Loeffler M; Daugas E; Susin S A; Zamzami N; Metivier D; Nieminen A L; Brothers G; Penninger J M; Kroemer G
Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):758-67.
2001: Diao J; Khine A A; Sarangi F; Hsu E; Iorio C; Tibbles L A; Woodgett J R; Penninger J; Richardson C D
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
The Journal of biological chemistry 2001;276(11):8328-40.
2001: Tafuri A; Shahinian A; Bladt F; Yoshinaga S K; Jordana M; Wakeham A; Boucher L M; Bouchard D; Chan V S; Duncan G; Odermatt B; Ho A; Itie A; Horan T; Whoriskey J S; Pawson T; Penninger J M; Ohashi P S; Mak T W
ICOS is essential for effective T-helper-cell responses.
Nature 2001;409(6816):105-9.
2001: Irie-Sasaki J; Sasaki T; Matsumoto W; Opavsky A; Cheng M; Welstead G; Griffiths E; Krawczyk C; Richardson C D; Aitken K; Iscove N; Koretzky G; Johnson P; Liu P; Rothstein D M; Penninger J M
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.
Nature 2001;409(6818):349-54.
2000: Matsumoto G; Omi Y; Lee U; Nishimura T; Shindo J; Penninger J M
Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity.
European journal of immunology 2000;30(12):3723-31.
2000: Kong Y Y; Penninger J M
Molecular control of bone remodeling and osteoporosis.
Experimental gerontology 2000;35(8):947-56.
2000: Kong Y Y; Boyle W J; Penninger J M
Osteoprotegerin ligand: a regulator of immune responses and bone physiology.
Immunology today 2000;21(10):495-502.
2000: Krawczyk C; Bachmaier K; Sasaki T; Jones R G; Snapper S B; Bouchard D; Kozieradzki I; Ohashi P S; Alt F W; Penninger J M
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.
Immunity 2000;13(4):463-73.
2000: Ferri K F; Jacotot E; Blanco J; Esté J A; Zamzami N; Susin S A; Xie Z; Brothers G; Reed J C; Penninger J M; Kroemer G
Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.
The Journal of experimental medicine 2000;192(8):1081-92.
2000: Oliveira-Dos-Santos A J; Matsumoto G; Snow B E; Bai D; Houston F P; Whishaw I Q; Mariathasan S; Sasaki T; Wakeham A; Ohashi P S; Roder J C; Barnes C A; Siderovski D P; Penninger J M
Regulation of T cell activation, anxiety, and male aggression by RGS2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12272-7.
2000: Fata J E; Kong Y Y; Li J; Sasaki T; Irie-Sasaki J; Moorehead R A; Elliott R; Scully S; Voura E B; Lacey D L; Boyle W J; Khokha R; Penninger J M
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
Cell 2000;103(1):41-50.
2000: Teng Y T; Nguyen H; Gao X; Kong Y Y; Gorczynski R M; Singh B; Ellen R P; Penninger J M
Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection.
The Journal of clinical investigation 2000;106(6):R59-67.
2000: Sasaki T; Irie-Sasaki J; Horie Y; Bachmaier K; Fata J E; Li M; Suzuki A; Bouchard D; Ho A; Redston M; Gallinger S; Khokha R; Mak T W; Hawkins P T; Stephens L; Scherer S W; Tsao M; Penninger J M
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.
Nature 2000;406(6798):897-902.
2000: Susin S A; Daugas E; Ravagnan L; Samejima K; Zamzami N; Loeffler M; Costantini P; Ferri K F; Irinopoulou T; Prévost M C; Brothers G; Mak T W; Penninger J; Earnshaw W C; Kroemer G
Two distinct pathways leading to nuclear apoptosis.
The Journal of experimental medicine 2000;192(4):571-80.
2000: Bachmaier K; Le J; Penninger J M
"Catching heart disease": antigenic mimicry and bacterial infections.
Nature medicine 2000;6(8):841-2.
2000: Penninger J M; Bachmaier K
Review of microbial infections and the immune response to cardiac antigens.
The Journal of infectious diseases 2000;181 Suppl 3():S498-504.
2000: Daugas E; Susin S A; Zamzami N; Ferri K F; Irinopoulou T; Larochette N; Prévost M C; Leber B; Andrews D; Penninger J; Kroemer G
Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):729-39.
2000: Liu P; Aitken K; Kong Y Y; Opavsky M A; Martino T; Dawood F; Wen W H; Kozieradzki I; Bachmaier K; Straus D; Mak T W; Penninger J M
The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Nature medicine 2000;6(4):429-34.
2000: Sasaki T; Irie-Sasaki J; Jones R G; Oliveira-dos-Santos A J; Stanford W L; Bolon B; Wakeham A; Itie A; Bouchard D; Kozieradzki I; Joza N; Mak T W; Ohashi P S; Suzuki A; Penninger J M
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science (New York, N.Y.) 2000;287(5455):1040-6.
2000: Bachmaier K; Krawczyk C; Kozieradzki I; Kong Y Y; Sasaki T; Oliveira-dos-Santos A; Mariathasan S; Bouchard D; Wakeham A; Itie A; Le J; Ohashi P S; Sarosi I; Nishina H; Lipkowitz S; Penninger J M
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Nature 2000;403(6766):211-6.
1999: Kong Y Y; Feige U; Sarosi I; Bolon B; Tafuri A; Morony S; Capparelli C; Li J; Elliott R; McCabe S; Wong T; Campagnuolo G; Moran E; Bogoch E R; Van G; Nguyen L T; Ohashi P S; Lacey D L; Fish E; Boyle W J; Penninger J M
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Nature 1999;402(6759):304-9.
1999: Zhang J; Shehabeldin A; da Cruz L A; Butler J; Somani A K; McGavin M; Kozieradzki I; dos Santos A O; Nagy A; Grinstein S; Penninger J M; Siminovitch K A
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.
The Journal of experimental medicine 1999;190(9):1329-42.
1999: Opavsky M A; Penninger J; Aitken K; Wen W H; Dawood F; Mak T; Liu P
Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection.
Circulation research 1999;85(6):551-8.
1999: Bachmann M F; Nitschke L; Krawczyk C; Tedford K; Ohashi P S; Fischer K D; Penninger J M
The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):137-42.
1999: Lorenzo H K; Susin S A; Penninger J; Kroemer G
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death.
Cell death and differentiation 1999;6(6):516-24.
1999: Keane M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S
cbl-3: a new mammalian cbl family protein.
Oncogene 1999;18(22):3365-75.
1999: Penninger J M; Fischer K D; Sasaki T; Kozieradzki I; Le J; Tedford K; Bachmaier K; Ohashi P S; Bachmann M F
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
European journal of immunology 1999;29(5):1709-18.
1999: Khan Q; Penninger J M; Yang L; Marra L E; Kozieradzki I; Zhang L
Regulation of apoptosis in mature alphabeta+CD4-CD8- antigen-specific suppressor T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5860-7.
1999: Lomaga M A; Yeh W C; Sarosi I; Duncan G S; Furlonger C; Ho A; Morony S; Capparelli C; Van G; Kaufman S; van der Heiden A; Itie A; Wakeham A; Khoo W; Sasaki T; Cao Z; Penninger J M; Paige C J; Lacey D L; Dunstan C R; Boyle W J; Goeddel D V; Mak T W
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & development 1999;13(8):1015-24.
1999: Oliveira-dos-Santos A J; Ho A; Tada Y; Lafaille J J; Tonegawa S; Mak T W; Penninger J M
CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4490-5.
1999: Bachmaier K; Neu N; Yeung R S; Mak T W; Liu P; Penninger J M
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Circulation 1999;99(14):1885-91.
1999: Liu Q; Sasaki T; Kozieradzki I; Wakeham A; Itie A; Dumont D J; Penninger J M
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.
Genes & development 1999;13(7):786-91.
1999: Irwin M W; Mak S; Mann D L; Qu R; Penninger J M; Yan A; Dawood F; Wen W H; Shou Z; Liu P
Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium.
Circulation 1999;99(11):1492-8.
1999: Hakem A; Sasaki T; Kozieradzki I; Penninger J M
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
The Journal of experimental medicine 1999;189(6):957-68.
1999: Bachmaier K; Neu N; de la Maza L M; Pal S; Hessel A; Penninger J M
Chlamydia infections and heart disease linked through antigenic mimicry.
Science (New York, N.Y.) 1999;283(5406):1335-9.
1999: Susin S A; Lorenzo H K; Zamzami N; Marzo I; Snow B E; Brothers G M; Mangion J; Jacotot E; Costantini P; Loeffler M; Larochette N; Goodlett D R; Aebersold R; Siderovski D P; Penninger J M; Kroemer G
Molecular characterization of mitochondrial apoptosis-inducing factor.
Nature 1999;397(6718):441-6.
1999: Nishina H; Vaz C; Billia P; Nghiem M; Sasaki T; De la Pompa J L; Furlonger K; Paige C; Hui C; Fischer K D; Kishimoto H; Iwatsubo T; Katada T; Woodgett J R; Penninger J M
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.
Development (Cambridge, England) 1999;126(3):505-16.
1999: Penninger J M; Crabtree G R
The actin cytoskeleton and lymphocyte activation.
Cell 1999;96(1):9-12.
1999: Kong Y Y; Yoshida H; Sarosi I; Tan H L; Timms E; Capparelli C; Morony S; Oliveira-dos-Santos A J; Van G; Itie A; Khoo W; Wakeham A; Dunstan C R; Lacey D L; Mak T W; Boyle W J; Penninger J M
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Nature 1999;397(6717):315-23.
1998: Kong Y Y; Fischer K D; Bachmann M F; Mariathasan S; Kozieradzki I; Nghiem M P; Bouchard D; Bernstein A; Ohashi P S; Penninger J M
Vav regulates peptide-specific apoptosis in thymocytes.
The Journal of experimental medicine 1998;188(11):2099-111.
1998: Penninger J M; Mak T W
Thymocyte selection in Vav and IRF-1 gene-deficient mice.
Immunological reviews 1998;165():149-66.
1998: Stambolic V; Suzuki A; de la Pompa J L; Brothers G M; Mirtsos C; Sasaki T; Ruland J; Penninger J M; Siderovski D P; Mak T W
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Cell 1998;95(1):29-39.
1998: Liu Q; Oliveira-Dos-Santos A J; Mariathasan S; Bouchard D; Jones J; Sarao R; Kozieradzki I; Ohashi P S; Penninger J M; Dumont D J
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.
The Journal of experimental medicine 1998;188(7):1333-42.
1998: Nishina H; Radvanyi L; Raju K; Sasaki T; Kozieradzki I; Penninger J M
Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3416-20.
1998: Yoshida H; Kong Y Y; Yoshida R; Elia A J; Hakem A; Hakem R; Penninger J M; Mak T W
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
Cell 1998;94(6):739-50.
1998: Boyd R; Kozieradzki I; Chidgey A; Mittrücker H W; Bouchard D; Timms E; Kishihara K; Ong C J; Chui D; Marth J D; Mak T W; Penninger J M
Receptor-specific allelic exclusion of TCRV alpha-chains during development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1718-27.
1998: Hakem R; Hakem A; Duncan G S; Henderson J T; Woo M; Soengas M S; Elia A; de la Pompa J L; Kagi D; Khoo W; Potter J; Yoshida R; Kaufman S A; Lowe S W; Penninger J M; Mak T W
Differential requirement for caspase 9 in apoptotic pathways in vivo.
Cell 1998;94(3):339-52.
1998: Fischer K D; Tedford K; Penninger J M
Vav links antigen-receptor signaling to the actin cytoskeleton.
Seminars in immunology 1998;10(4):317-27.
1998: Matsumoto G; Nghiem M P; Nozaki N; Schmits R; Penninger J M
Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5781-9.
1998: Fischer K D; Kong Y Y; Nishina H; Tedford K; Marengère L E; Kozieradzki I; Sasaki T; Starr M; Chan G; Gardener S; Nghiem M P; Bouchard D; Barbacid M; Bernstein A; Penninger J M
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Current biology : CB 1998;8(10):554-62.
1998: Yoshida H; Nishina H; Takimoto H; Marengère L E; Wakeham A C; Bouchard D; Kong Y Y; Ohteki T; Shahinian A; Bachmann M; Ohashi P S; Penninger J M; Crabtree G R; Mak T W
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
Immunity 1998;8(1):115-24.
1997: Nishina H; Bachmann M; Oliveira-dos-Santos A J; Kozieradzki I; Fischer K D; Odermatt B; Wakeham A; Shahinian A; Takimoto H; Bernstein A; Mak T W; Woodgett J R; Ohashi P S; Penninger J M
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
The Journal of experimental medicine 1997;186(6):941-53.
1997: Waterhouse P; Bachmann M F; Penninger J M; Ohashi P S; Mak T W
Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice.
European journal of immunology 1997;27(8):1887-92.
1997: Penninger J M; Sirard C; Mittrücker H W; Chidgey A; Kozieradzki I; Nghiem M; Hakem A; Kimura T; Timms E; Boyd R; Taniguchi T; Matsuyama T; Mak T W
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.
Immunity 1997;7(2):243-54.
1997: Bachmaier K; Neu N; Pummerer C; Duncan G S; Mak T W; Matsuyama T; Penninger J M
iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.
Circulation 1997;96(2):585-91.
1997: Marengère L E; Mirtsos C; Kozieradzki I; Veillette A; Mak T W; Penninger J M
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):70-6.
1997: Wallace V A; Penninger J M; Kishihara K; Timms E; Shahinian A; Pircher H; Kündig T M; Ohashi P S; Mak T W
Alterations in the level of CD45 surface expression affect the outcome of thymic selection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3205-14.
1997: Kozieradzki I; Kündig T; Kishihara K; Ong C J; Chiu D; Wallace V A; Kawai K; Timms E; Ionescu J; Ohashi P; Marth J D; Mak T W; Penninger J M
T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3130-9.
1997: Bachmaier K; Pummerer C; Kozieradzki I; Pfeffer K; Mak T W; Neu N; Penninger J M
Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease.
Circulation 1997;95(3):655-61.
1997: Penninger J M; Pummerer C; Liu P; Neu N; Bachmaier K
Cellular and molecular mechanisms of murine autoimmune myocarditis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(1):1-13.
1997: Nishina H; Fischer K D; Radvanyi L; Shahinian A; Hakem R; Rubie E A; Bernstein A; Mak T W; Woodgett J R; Penninger J M
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3.
Nature 1997;385(6614):350-3.
1996: Penninger J M; Wallace V A; Molina T; Mak T W
Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck).
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5359-66.
1996: Liu P; Martino T; Opavsky M A; Penninger J
Viral myocarditis: balance between viral infection and immune response.
The Canadian journal of cardiology 1996;12(10):935-43.
1996: Bachmaier K; Pummerer C; Shahinian A; Ionescu J; Neu N; Mak T W; Penninger J M
Induction of autoimmunity in the absence of CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1752-7.
1996: Yeung R S; Penninger J M; Kündig T; Khoo W; Ohashi P S; Kroemer G; Mak T W
Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock.
European journal of immunology 1996;26(5):1074-82.
1996: Pummerer C L; Grässl G; Sailer M; Bachmaier K W; Penninger J M; Neu N
Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells.
Laboratory investigation; a journal of technical methods and pathology 1996;74(5):845-52.
1996: Pummerer C L; Luze K; Grässl G; Bachmaier K; Offner F; Burrell S K; Lenz D M; Zamborelli T J; Penninger J M; Neu N
Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.
The Journal of clinical investigation 1996;97(9):2057-62.
1996: Amakawa R; Hakem A; Kundig T M; Matsuyama T; Simard J J; Timms E; Wakeham A; Mittruecker H W; Griesser H; Takimoto H; Schmits R; Shahinian A; Ohashi P; Penninger J M; Mak T W
Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.
Cell 1996;84(4):551-62.
1995: Waterhouse P; Penninger J M; Timms E; Wakeham A; Shahinian A; Lee K P; Thompson C B; Griesser H; Mak T W
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
Science (New York, N.Y.) 1995;270(5238):985-8.
1995: Penninger J M; Timms E; Shahinian A; Jezo-Bremond A; Nishina H; Ionescu J; Hedrick S M; Mak T W
Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3847-55.
1995: Rieker T; Penninger J; Romani N; Wick G
Chicken thymic nurse cells: an overview.
Developmental and comparative immunology 1995;19(4):281-9.
1995: Penninger J M; Schilham M W; Timms E; Wallace V A; Mak T W
T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules.
European journal of immunology 1995;25(7):2115-8.
1995: Wallace V A; Kawai K; Levelt C N; Kishihara K; Molina T; Timms E; Pircher H; Penninger J; Ohashi P S; Eichmann K
T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.
European journal of immunology 1995;25(5):1312-8.
1995: Penninger J M; Wen T; Timms E; Potter J; Wallace V A; Matsuyama T; Ferrick D; Sydora B; Kronenberg M; Mak T W
Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice.
Nature 1995;375(6528):241-4.
1994: Penninger J M; Mak T W
Signal transduction, mitotic catastrophes, and death in T-cell development.
Immunological reviews 1994;142():231-72.
1994: Yeung R S; Penninger J M; Kündig T M; Law Y; Yamamoto K; Kamikawaji N; Burkly L; Sasazuki T; Flavell R; Ohashi P S; Mak T W
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.
The Journal of experimental medicine 1994;180(5):1911-20.
1994: Koh D R; Ho A; Rahemtulla A; Penninger J; Mak T W
Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells.
European journal of immunology 1994;24(9):2250-3.
1994: Penninger J M; Wallace V A; Timms E; Mak T W
Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells.
European journal of immunology 1994;24(5):1102-8.
1994: Yeung R S; Penninger J; Mak T W
T-cell development and function in gene-knockout mice.
Current opinion in immunology 1994;6(2):298-307.
1994: Penninger J; Rieker T; Romani N; Klima J; Salvenmoser W; Dietrich H; Stössel H; Wick G
Ultrastructural analysis of thymic nurse cell epithelium.
European journal of immunology 1994;24(1):222-8.
1994: Ferrick D A; Gemmell-Hori L; Sydora B; Mulvania T; Penninger J M; Kronenberg M; Mak T W
Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice.
International reviews of immunology 1994;11(4):295-304.
1993: Penninger J M; Neu N; Timms E; Wallace V A; Koh D R; Kishihara K; Pummerer C; Mak T W
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
The Journal of experimental medicine 1993;178(5):1837-42.
1993: Penninger J M; Wallace V A; Kishihara K; Mak T W
The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection.
Immunological reviews 1993;135():183-214.
1993: Yeung R S; Penninger J; Mak T W
Genetically modified animals and immunodeficiency.
Current opinion in immunology 1993;5(4):585-94.
1993: Kishihara K; Penninger J; Wallace V A; Kündig T M; Kawai K; Wakeham A; Timms E; Pfeffer K; Ohashi P S; Thomas M L
Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice.
Cell 1993;74(1):143-56.
1993: Wallace V A; Penninger J; Mak T W
CD4, CD8 and tyrosine kinases in thymic selection.
Current opinion in immunology 1993;5(2):235-40.
1993: Penninger J; Kishihara K; Molina T; Wallace V A; Timms E; Hedrick S M; Mak T W
Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells.
Science (New York, N.Y.) 1993;260(5106):358-61.
1993: Rieker T; Penninger J; Hala K; Cooper M D; Wick G
In situ analyses of in ovo graft-vs.-host reaction induced by thymic nurse cell lymphocytes.
European journal of immunology 1993;23(4):904-10.
1992: Wallace V A; Fung-Leung W P; Timms E; Gray D; Kishihara K; Loh D Y; Penninger J; Mak T W
CD45RA and CD45RBhigh expression induced by thymic selection events.
The Journal of experimental medicine 1992;176(6):1657-63.
1992: Wallace V A; Rahemtulla A; Timms E; Penninger J; Mak T W
CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.
The Journal of experimental medicine 1992;176(5):1459-63.
1992: Penninger J; Wick G
Thymic nurse cell lymphocytes react against self major histocompatibility complex.
European journal of immunology 1992;22(1):79-83.
1991: Wick G; Rieker T; Penninger J
Thymic nurse cells: a site for positive selection and differentiation of T cells.
Current topics in microbiology and immunology 1991;173():99-105.
1991: Cheng S H; Penninger J M; Ferrick D A; Molina T J; Wallace V A; Mak T W
Biology of murine gamma delta T cells.
Critical reviews in immunology 1991;11(3-4):145-66.
1991: Penninger J; Wallace V A; Kishihara K; Molina T; Krause H; Mak T W
Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors.
Experimental and clinical immunogenetics 1991;8(2):57-74.
1990: Penninger J; Hála K; Wick G
Intrathymic nurse cell lymphocytes can induce a specific graft-versus-host reaction.
The Journal of experimental medicine 1990;172(2):521-9.
1989: Penninger J; Klima J; Kroemer G; Dietrich H; Hala K; Wick G
Intra-thymic nurse cell lymphocytes can induce a graft-versus-host reaction with high efficiency.
Developmental and comparative immunology 1989;13(4):313-27.

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