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Markku Pentikäinen

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Marit Granér; Antti Hakkarainen; Kirsi Lauerma; Jesper Lundbom; Nina Lundbom; Markku S Nieminen; Kristofer Nyman; Markku O Pentikäinen; Reijo Siren; Martin Adiels; Marja-Riitta Taskinen
Cardiac steatosis associates with visceral obesity in nondiabetic obese men.
Hanna M Heikkilä; Julia Trosien; Jari Metso; Matti Jauhiainen; Markku O Pentikäinen; Petri T Kovanen; Ken A Lindstedt
Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation.
Riina Oksjoki; Petri Laine; Satu Helske; Pirjo Vehmaan-Kreula; Mikko I Mäyränpää; Philippe Gasque; Petri T Kovanen; Markku O Pentikäinen
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques.

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All Publications

2013: Marit Granér; Antti Hakkarainen; Kirsi Lauerma; Jesper Lundbom; Nina Lundbom; Markku S Nieminen; Kristofer Nyman; Markku O Pentikäinen; Reijo Siren; Martin Adiels; Marja-Riitta Taskinen
Cardiac steatosis associates with visceral obesity in nondiabetic obese men.
The Journal of clinical endocrinology and metabolism 2013;98(3):1189-97.
2010: Hanna M Heikkilä; Julia Trosien; Jari Metso; Matti Jauhiainen; Markku O Pentikäinen; Petri T Kovanen; Ken A Lindstedt
Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation.
Journal of cellular biochemistry 2010;109(3):615-23.
2007: Riina Oksjoki; Petri Laine; Satu Helske; Pirjo Vehmaan-Kreula; Mikko I Mäyränpää; Philippe Gasque; Petri T Kovanen; Markku O Pentikäinen
Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques.
Atherosclerosis 2007;195(1):90-9.
2007: Riina Oksjoki; Petri T Kovanen; Mikko I Mäyränpää; Petri Laine; Anna M Blom; Seppo Meri; Markku O Pentikäinen
Complement regulation in human atherosclerotic coronary lesions. Immunohistochemical evidence that C4b-binding protein negatively regulates the classical complement pathway, and that C5b-9 is formed via the alternative complement pathway.
Atherosclerosis 2007;192(1):40-8.
2006: Jukka K Hakala; Ken A Lindstedt; Petri T Kovanen; Markku O Pentikäinen
Low-density lipoprotein modified by macrophage-derived lysosomal hydrolases induces expression and secretion of IL-8 via p38 MAPK and NF-kappaB by human monocyte-derived macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2504-9.
2006: Petru Liuba; Erkki Pesonen; Anders Forslid; Ilari Paakkari; Axel Kornerup-Hansen; Petri T Kovanen; Markku O Pentikäinen; Kenneth Persson; Grete Østergård
Protective effects of simvastatin on coronary artery function in swine with acute infection.
Atherosclerosis 2006;186(2):331-6.
2006: Riina Oksjoki; Petri T Kovanen; Ken A Lindstedt; Bo Jansson; Markku O Pentikäinen
OxLDL-IgG immune complexes induce survival of human monocytes.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):576-83.
2005: Sanna Taskinen; Marja T Hyvönen; Petri T Kovanen; Seppo Meri; Markku O Pentikäinen
C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles.
Biochemical and biophysical research communications 2005;329(4):1208-16.
2005: Petri T Kovanen; Markku O Pentikäinen
[Intensive lipid lowering statin therapy immediately after acute coronary syndrome].
Duodecim; lääketieteellinen aikakauskirja 2005;121(10):1029-32.
2005: Marjut Otala; Markku O Pentikäinen; Tiina Matikainen; Laura Suomalainen; Jukka K Hakala; Gloria I Perez; Mikko Tenhunen; Krista Erkkilä; Petri T Kovanen; Martti Parvinen; Leo Dunkel
Effects of acid sphingomyelinase deficiency on male germ cell development and programmed cell death.
Biology of reproduction 2005;72(1):86-96.
2004: Helena Lappalainen; Petri Laine; Markku O Pentikäinen; Antti Sajantila; Petri T Kovanen
Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor, a potent angiogenic mediator.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(10):1880-5.
2004: Katariina Öörni; Mia Sneck; Dieter Brömme; Markku O Pentikäinen; Ken A Lindstedt; Mikko I Mäyränpää; Helena Aitio; Petri T Kovanen
Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.
The Journal of biological chemistry 2004;279(33):34776-84.
2004: Marjut Otala; Laura Suomalainen; Markku O Pentikäinen; Petri T Kovanen; Mikko Tenhunen; Krista Erkkilä; Jorma Toppari; Leo Dunkel
Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate.
Biology of reproduction 2004;70(3):759-67.
2003: Laura Suomalainen; Jukka K Hakala; Virve Pentikäinen; Marjut Otala; Krista Erkkilä; Markku O Pentikäinen; Leo Dunkel
Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis.
The Journal of clinical endocrinology and metabolism 2003;88(11):5572-9.
2003: Riina Oksjoki; Petri T Kovanen; Markku O Pentikäinen
Role of complement activation in atherosclerosis.
Current opinion in lipidology 2003;14(5):477-82.
2003: Petri T Kovanen; Markku O Pentikäinen
Circulating lipoproteins as proinflammatory and anti-inflammatory particles in atherogenesis.
Current opinion in lipidology 2003;14(5):411-9.
2003: Jukka K Hakala; Riina Oksjoki; Petri Laine; Hong Du; Gregory A Grabowski; Petri T Kovanen; Markku O Pentikäinen
Lysosomal enzymes are released from cultured human macrophages, hydrolyze LDL in vitro, and are present extracellularly in human atherosclerotic lesions.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1430-6.
2003: Petru Liuba; Erkki Pesonen; Ilari Paakkari; satish c batra; Anders Forslid; Petri T Kovanen; Markku O Pentikäinen; Kenneth Persson; Staffan Sandström
Acute Chlamydia pneumoniae infection causes coronary endothelial dysfunction in pigs.
Atherosclerosis 2003;167(2):215-22.
2003: Riina Oksjoki; Hanna Jarva; Petri T Kovanen; Petri Laine; Seppo Meri; Markku O Pentikäinen
Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):630-6.
2003: Paul Cullen; Roberta Baetta; Stefano Bellosta; Franco Bernini; Giulia Chinetti; Andrea Cignarella; Arnold von Eckardstein; Andrew Exley; Martin Goddard; Marten H Hofker; Eva Hurt-Camejo; Edwin Kanters; Petri T Kovanen; Stefan Lorkowski; William McPheat; Markku O Pentikäinen; Jürgen Rauterberg; Andrew Ritchie; Bart Staels; Benedikt Weitkamp; Menno de Winther
Rupture of the atherosclerotic plaque: does a good animal model exist?
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):535-42.
2003: Petri T Kovanen; Markku O Pentikäinen
Pharmacological evidence for a role of liver X receptors in atheroprotection.
FEBS letters 2003;536(1-3):3-5.
2002: Sanna Taskinen; Petri T Kovanen; Hanna Jarva; Seppo Meri; Markku O Pentikäinen
Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein.
The Biochemical journal 2002;367(Pt 2):403-12.
2002: Petri Laine; Markku O Pentikäinen; Reinhard Wurzner; Antti Penttilä; Timo Paavonen; Seppo Meri; Petri T Kovanen
Evidence for complement activation in ruptured coronary plaques in acute myocardial infarction.
The American journal of cardiology 2002;90(4):404-8.
2002: Stefano Bellosta; Franco Bernini; Giulia Chinetti; Andrea Cignarella; Paul Cullen; Arnold von Eckardstein; A Exley; J Freeth; M Goddard; M Hofker; E Kanters; P Kovanen; Stefan Lorkowski; Markku O Pentikäinen; J Printen; Jürgen Rauterberg; Andrew Ritchie; Bart Staels; Benedikt Weitkamp; Menno de Winther
Macrophage function and stability of the atherosclerotic plaque: progress report of a European project.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2002;12(1):3-11.
2002: Markku O Pentikäinen; Riina Oksjoki; Katariina Öörni; Petri T Kovanen
Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(2):211-7.
2002: Virve Pentikäinen; Laura Suomalainen; Krista Erkkilä; Eeva Martelin; Martti Parvinen; Markku O Pentikäinen; Leo Dunkel
Nuclear factor-kappa B activation in human testicular apoptosis.
The American journal of pathology 2002;160(1):205-18.
2001: Markku O Pentikäinen; Katariina Öörni; Petri T Kovanen
Myeloperoxidase and hypochlorite, but not copper ions, oxidize heparin-bound LDL particles and release them from heparin.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1902-8.
2001: Virve Pentikäinen; Krista Erkkilä; Laura Suomalainen; Marjut Otala; Markku O Pentikäinen; Martti Parvinen; Leo Dunkel
TNFalpha down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis.
The Journal of clinical endocrinology and metabolism 2001;86(9):4480-8.
2001: Jukka K Hakala; Katariina Öörni; Markku O Pentikäinen; Eva Hurt-Camejo; Petri T Kovanen
Lipolysis of LDL by human secretory phospholipase A(2) induces particle fusion and enhances the retention of LDL to human aortic proteoglycans.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(6):1053-8.
2001: Markku O Pentikäinen; Marja T Hyvönen; Katariina Öörni; T Hevonoja; Arja Korhonen; E M Lehtonen-Smeds; Mika Ala-Korpela; Petri T Kovanen
Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles.
Journal of lipid research 2001;42(6):916-22.
2000: T Hevonoja; Markku O Pentikäinen; Marja T Hyvönen; Petri T Kovanen; Mika Ala-Korpela
Structure of low density lipoprotein (LDL) particles: basis for understanding molecular changes in modified LDL.
Biochimica et biophysica acta 2000;1488(3):189-210.
2000: Katariina Öörni; Markku O Pentikäinen; Mika Ala-Korpela; Petri T Kovanen
Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions.
Journal of lipid research 2000;41(11):1703-14.
2000: Markku O Pentikäinen; Katariina Öörni; Mika Ala-Korpela; Petri Kovanen
Modified LDL - trigger of atherosclerosis and inflammation in the arterial intima.
Journal of internal medicine 2000;247(3):359-70.
2000: Markku O Pentikäinen; Katariina Öörni; Petri Kovanen
Lipoprotein lipase (LPL) strongly links native and oxidized low density lipoprotein particles to decorin-coated collagen. Roles for both dimeric and monomeric forms of LPL.
The Journal of biological chemistry 2000;275(8):5694-701.
1999: Petri T Kovanen; Markku O Pentikäinen
Decorin links low-density lipoproteins (LDL) to collagen: a novel mechanism for retention of LDL in the atherosclerotic plaque.
Trends in cardiovascular medicine 1999;9(3-4):86-91.
1998: Mika Ala-Korpela; Markku O Pentikäinen; Arja Korhonen; T Hevonoja; J Lounila; Petri T Kovanen
Detection of low density lipoprotein particle fusion by proton nuclear magnetic resonance spectroscopy.
Journal of lipid research 1998;39(8):1705-12.
1997: Markku O Pentikäinen; E M Lehtonen; Katariina Öörni; Sari Lusa / Löytökorpi; Pentti Somerharju; Matti Jauhiainen; Petri Kovanen
Human arterial proteoglycans increase the rate of proteolytic fusion of low density lipoprotein particles.
The Journal of biological chemistry 1997;272(40):25283-8.
1997: Katariina Öörni; Markku O Pentikäinen; A Annila; Petri T Kovanen
Oxidation of low density lipoprotein particles decreases their ability to bind to human aortic proteoglycans. Dependence on oxidative modification of the lysine residues.
The Journal of biological chemistry 1997;272(34):21303-11.
1997: Markku O Pentikäinen; Katariina Öörni; R Lassila; Petri T Kovanen
The proteoglycan decorin links low density lipoproteins with collagen type I.
The Journal of biological chemistry 1997;272(12):7633-8.
1996: Markku O Pentikäinen; E M Lehtonen; Petri T Kovanen
Aggregation and fusion of modified low density lipoprotein.
Journal of lipid research 1996;37(12):2638-49.
1995: Markku O Pentikäinen; Ken A Lindstedt; Petri T Kovanen
Inhibition of the oxidative modification of LDL by nitecapone.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(6):740-7.