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Leena Penttilä

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Sean R Stowell; Marcelo Dias-Baruffi; Leena Penttilä; Ossi Renkonen; A Kwame Nyame; Richard D Cummings
Human galectin-1 recognition of poly-N-acetyllactosamine and chimeric polysaccharides.
Hanna Salo; Olli Aitio; Kristiina Ilves; Eija Bencomo; Suvi Toivonen; Leena Penttilä; Ritva Niemelä; Heidi Salminen; Eckart Grabenhorst; Risto Renkonen; Ossi Renkonen
Several polylactosamine-modifying glycosyltransferases also use internal GalNAcbeta1-4GlcNAc units of synthetic saccharides as acceptors.
Jarkko Räbinä; Minna Mäki; E M Savilahti; Nina Järvinen; Leena Penttilä; Risto Renkonen
Analysis of nucleotide sugars from cell lysates by ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography.

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All Publications

2004: Sean R Stowell; Marcelo Dias-Baruffi; Leena Penttilä; Ossi Renkonen; A Kwame Nyame; Richard D Cummings
Human galectin-1 recognition of poly-N-acetyllactosamine and chimeric polysaccharides.
Glycobiology 2004;14(2):157-67.
2002: Hanna Salo; Olli Aitio; Kristiina Ilves; Eija Bencomo; Suvi Toivonen; Leena Penttilä; Ritva Niemelä; Heidi Salminen; Eckart Grabenhorst; Risto Renkonen; Ossi Renkonen
Several polylactosamine-modifying glycosyltransferases also use internal GalNAcbeta1-4GlcNAc units of synthetic saccharides as acceptors.
Glycobiology 2002;12(3):217-28.
2001: Jarkko Räbinä; Minna Mäki; E M Savilahti; Nina Järvinen; Leena Penttilä; Risto Renkonen
Analysis of nucleotide sugars from cell lysates by ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography.
Glycoconjugate journal 2001;18(10):799-805.
1999: Ritva Niemelä; Jari Natunen; Leena Penttilä; Heidi Salminen; Jari Helin; Hannu Maaheimo; CE Costello; Ossi Renkonen
Isolation and characterization of linear polylactosamines containing one and two site-specifically positioned Lewis x determinants: WGA agarose chromatography in fractionation of mixtures generated by random, partial enzymatic alpha3-fucosylation of pure polylactosamines.
Glycobiology 1999;9(5):517-26.
1999: S Toppila; Risto Renkonen; Leena Penttilä; Jari Natunen; Heidi Salminen; Jari Helin; Hannu Maaheimo; Ossi Renkonen
Enzymatic synthesis of alpha3'sialylated and multiply alpha3fucosylated biantennary polylactosamines. A bivalent [sialyl diLex]-saccharide inhibited lymphocyte-endothelium adhesion organ-selectively.
European journal of biochemistry / FEBS 1999;261(1):208-15.
1997: Heidi Salminen; K Ahokas; Ritva Niemelä; Leena Penttilä; Hannu Maaheimo; Jari Helin; CE Costello; Ossi Renkonen
Improved enzymatic synthesis of a highly potent oligosaccharide antagonist of L-selectin.
FEBS letters 1997;419(2-3):220-6.
1997: Jari Helin; Leena Penttilä; Anne Leppänen; Hannu Maaheimo; S Lauri; CE Costello; Ossi Renkonen
The beta 1,6-GlcNAc transferase activity present in hog gastric mucosal microsomes catalyses site-specific branch formation on a long polylactosamine backbone.
FEBS letters 1997;412(3):637-42.
1997: S Toppila; Jouni Lauronen; Pirkko Mattila; JP Turunen; Leena Penttilä; Timo Paavonen; Ossi Renkonen; Risto Renkonen
L-selectin ligands in rat high endothelium: multivalent sialyl Lewis x glycans are high-affinity inhibitors of lymphocyte adhesion.
European journal of immunology 1997;27(6):1360-5.
1997: Ossi Renkonen; S Toppila; Leena Penttilä; Heidi Salminen; Jari Helin; Hannu Maaheimo; CE Costello; JP Turunen; Risto Renkonen
Synthesis of a new nanomolar saccharide inhibitor of lymphocyte adhesion: different polylactosamine backbones present multiple sialyl Lewis x determinants to L-selectin in high-affinity mode.
Glycobiology 1997;7(4):453-61.
1996: A Seppo; J P Turunen; Leena Penttilä; A Keane; Ossi Renkonen; Risto Renkonen
Synthesis of a tetravalent sialyl Lewis x glycan, a high-affinity inhibitor of L-selectin-mediated lymphocyte binding to endothelium.
Glycobiology 1996;6(1):65-71.
1995: Hannu Maaheimo; Risto Renkonen; J P Turunen; Leena Penttilä; Ossi Renkonen
Synthesis of a divalent sialyl Lewis x O-glycan, a potent inhibitor of lymphocyte-endothelium adhesion. Evidence that multivalency enhances the saccharide binding to L-selectin.
European journal of biochemistry / FEBS 1995;234(2):616-25.
1995: J P Turunen; Marja-Leena Majuri; A Seppo; S Tiisala; Timo Paavonen; M Miyasaka; Karl B Lemström; Leena Penttilä; Ossi Renkonen; Risto Renkonen
De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion.
The Journal of experimental medicine 1995;182(4):1133-41.
1995: Ritva Niemelä; Leena Penttilä; A Seppo; Jari Helin; Anne Leppänen; Jarkko Räbinä; L Uusitalo; Hannu Maaheimo; Jyrki Taskinen; C E Costello
Enzyme-assisted synthesis of a bivalent high-affinity dodecasaccharide inhibitor of mouse gamete adhesion. The length of the chains carrying distal alpha 1,3-bonded galactose residues is critical.
FEBS letters 1995;367(1):67-72.
1995: Eveline S Litscher; K Juntunen; A Seppo; Leena Penttilä; Ritva Niemelä; Ossi Renkonen; Paul M Wassarman
Oligosaccharide constructs with defined structures that inhibit binding of mouse sperm to unfertilized eggs in vitro.
Biochemistry 1995;34(14):4662-9.
1995: A Seppo; Leena Penttilä; Ritva Niemelä; Hannu Maaheimo; Ossi Renkonen; A Keane
Enzymatic synthesis of octadecameric saccharides of multiply branched blood group I-type, carrying four distal alpha 1,3-galactose or beta 1,3-GlcNAc residues.
Biochemistry 1995;34(14):4655-61.
1994: Jari Natunen; Ritva Niemelä; Leena Penttilä; A Seppo; T Ruohtula; Ossi Renkonen
Enzymatic synthesis of two lacto-N-neohexaose-related Lewis x heptasaccharides and their separation by chromatography on immobilized wheat germ agglutinin.
Glycobiology 1994;4(5):577-83.
1994: Hannu Maaheimo; Leena Penttilä; Ossi Renkonen
Enzyme-aided construction of medium-sized alditols of complete O-linked saccharides. The constructed hexasaccharide alditol Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4GlcNAc beta 1-6(Gal beta 1-3)GalNAc-ol resists the action of endo-beta-galactosidase from Bacteroides fragilis.
FEBS letters 1994;349(1):55-9.
1994: A Seppo; Leena Penttilä; Anne Leppänen; Hannu Maaheimo; Ritva Niemelä; Jari Helin; J M Wieruszeski; Ossi Renkonen
Bi-antennary oligo-(N-acetyllactosamino)glycans of I-type are galactosylated preferentially at the GlcNAc beta 1-6Gal linked arms by alpha 1,3-galactosyltransferase of bovine thymus.
Glycoconjugate journal 1994;11(3):217-25.
1993: Jari Helin; A Seppo; Anne Leppänen; Leena Penttilä; Hannu Maaheimo; Ritva Niemelä; S Lauri; Ossi Renkonen
A novel beta-N-acetylglucosaminidase activity in hog gastric mucosal microsomes: preferential hydrolysis of terminal GlcNAc beta 1-3 linkages in GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, but GlcNAc beta 1-6 linkages in GlcNAc beta 1-3(GlcNAc beta 1-6)Gal.
FEBS letters 1993;335(2):280-4.
1992: A Vilkman; Ritva Niemelä; Leena Penttilä; Jari Helin; Anne Leppänen; A Seppo; Hannu Maaheimo; Sari Lusa / Löytökorpi; Ossi Renkonen
Elongation of both branches of biantennary backbones of oligo-(N-acetyllactosamino)glycans by human serum (1----3)-N-acetyl-beta-D- glucosaminyltransferase.
Carbohydrate research 1992;226(1):155-74.
1992: Ossi Renkonen; Anne Leppänen; Ritva Niemelä; A Vilkman; Jari Helin; Leena Penttilä; Hannu Maaheimo; A Seppo; J Suopanki
Enzymatic in vitro synthesis of radiolabeled pentasaccharides GlcNAc beta 1-3(Gal beta 1-4GlcNAc beta 1-6)Gal beta 1-4GlcNAc/Glc and the isomeric Gal beta 1-4GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc/Glc.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(1):86-9.
1991: Anne Leppänen; Leena Penttilä; Ritva Niemelä; Jari Helin; A Seppo; Sari Lusa / Löytökorpi; Ossi Renkonen
Human serum contains a novel beta 1,6-N-acetylglucosaminyltransferase activity that is involved in midchain branching of oligo (N-acetyllactosaminoglycans).
Biochemistry 1991;30(38):9287-96.
1991: Ossi Renkonen; Leena Penttilä; Ritva Niemelä; Anne Leppänen
Single mid-chain GlcNAc beta 1-6Gal beta 1-4R sequences of linear oligosaccharides are resistant to endo-beta-galactosidase of Bacteroides fragilis.
Glycoconjugate journal 1991;8(4):376-80.
1991: Ossi Renkonen; Ritva Niemelä; Anne Leppänen; Hannu Maaheimo; A Seppo; Leena Penttilä; A Vilkman
Construction of linear GlcNAc beta 1-6Gal beta 1-OR type oligosaccharides by partial cleavage of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-OR sequences with jack bean beta-N-acetylhexosaminidase.
Glycoconjugate journal 1991;8(4):368-75.
1991: Ossi Renkonen; Jari Helin; Leena Penttilä; Hannu Maaheimo; Ritva Niemelä; Anne Leppänen; A Seppo; K Hård
Oligo-N-acetyllactosaminoglycans bearing Gal beta 1-4(Fuc alpha 1-3)GlcNAc sequences reveal lower affinities than their nonfucosylated, or alpha(1-2) fucosylated counterparts for immobilized wheat germ agglutinin.
Glycoconjugate journal 1991;8(4):361-7.
1991: Ossi Renkonen; Leena Penttilä; Ritva Niemelä; A Vainio; Anne Leppänen; Jari Helin; A Seppo; A Makkonen; Hannu Maaheimo
N-acetyllactosaminooligosaccharides that contain the beta-D-GlcpNAc-(1----6)-D-Gal or beta-D-GlcpNAc-(1----6)-D-GalNAc sequences reveal reduction-sensitive affinities for wheat germ agglutinin.
Carbohydrate research 1991;213():169-83.
1990: Ossi Renkonen; Jari Helin; A Vainio; Ritva Niemelä; Leena Penttilä; P Hilden
Escherichia coli beta-galactosidase unexpectedly cleaves the hexasaccharide Gal beta 1-4GlcNAc beta 1-3(Gal beta 1-4GlcNAc beta 1-6)Gal beta 1-4GlcNAc without branch specificity.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(7-8):1032-6.
1990: A Seppo; Leena Penttilä; A Makkonen; Anne Leppänen; Ritva Niemelä; Jussi Jäntti; Jari Helin; Ossi Renkonen
Erratum: Wheat germ agglutinin chromatography of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal and GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, obtained by in vitro synthesis and by partial cleavage of teratocarcinoma poly-N-acetyllactosaminoglycans.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(3):685-6.
1990: A Seppo; Leena Penttilä; A Makkonen; Anne Leppänen; Ritva Niemelä; Jussi Jäntti; Jari Helin; Ossi Renkonen
Wheat germ agglutinin chromatography of GlcNac beta 1-3(GlcNAc beta 1-6)Gal and GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, obtained by in vitro synthesis and by partial cleavage of teratocarcinoma poly-N-acetyllactosaminoglycans.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(1):44-53.
1989: Ossi Renkonen; Leena Penttilä; A Makkonen; Ritva Niemelä; Anne Leppänen; Jari Helin; A Vainio
The linear tetrasaccharide, Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4GlcNAc, isolated from radiolabeled teratocarcinoma poly-N-acetyllactosaminoglycan resists the action of E. freundii endo-beta-galactosidase.
Glycoconjugate journal 1989;6(1):129-40.
1988: Ossi Renkonen; P Mäkinen; K Hård; Jari Helin; Leena Penttilä
Immobilized wheat germ agglutinin separates small oligosaccharides derived from poly-N-acetyllactosaminoglycans of embryonal carcinoma cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(5):449-53.