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Elisabeth Perchellet

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Mouse

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Jean-Pierre H Perchellet; Conrad Santini; Paul D Thornton; Andrew M Waters; Nalin Chandrasoma; David Hill; Gerald H Lushington; Ben Neuenswander; Elisabeth M Perchellet; Neil Brown; Keith R Buszek
Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro.
Jean-Pierre H Perchellet; Andrew M Waters; Kusum L Chandra; John Desper; Vijaya K Naganaboina; Elisabeth M Perchellet; Sundeep Rayat
Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro.
Aditya S Gundugola; Kusum Lata Chandra; Elisabeth M Perchellet; Andrew M Waters; Jean-Pierre H Perchellet; Sundeep Rayat
Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles.

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2012: Jean-Pierre H Perchellet; Conrad Santini; Paul D Thornton; Andrew M Waters; Nalin Chandrasoma; David Hill; Gerald H Lushington; Ben Neuenswander; Elisabeth M Perchellet; Neil Brown; Keith R Buszek
Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro.
Anticancer research 2012;32(11):4671-84.
2011: Jean-Pierre H Perchellet; Andrew M Waters; Kusum L Chandra; John Desper; Vijaya K Naganaboina; Elisabeth M Perchellet; Sundeep Rayat
Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro.
Anticancer research 2011;31(6):2083-93.
2010: Aditya S Gundugola; Kusum Lata Chandra; Elisabeth M Perchellet; Andrew M Waters; Jean-Pierre H Perchellet; Sundeep Rayat
Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles.
Bioorganic & medicinal chemistry letters 2010;20(13):3920-4.
2010: Elisabeth M Perchellet; Kyle R Crow; Gunjan Gakhar; Thu Annelise Nguyen; Aibin Shi; Duy H Hua; Jean-Pierre H Perchellet
Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro.
International journal of oncology 2010;36(3):673-88.
2009: Jean-Pierre H Perchellet; Elisabeth M Perchellet; Kyle R Crow; Keith R Buszek; Neil Brown; Sampathkumar Ellappan; Ge Gao; Diheng Luo; Machiko Minatoya; Gerald H Lushington
Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins.
International journal of molecular medicine 2009;24(5):633-43.
2009: Elisabeth M Perchellet; Jean-Pierre H Perchellet; Chanran K Ganta; Deryl L Troyer; Aibin Shi; Duy H Hua
Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery.
Anti-cancer agents in medicinal chemistry 2009;9(8):864-76.
2008: Neil Brown; Baohan Xie; Nataliya Markina; David VanderVelde; Jean-Pierre H Perchellet; Elisabeth M Perchellet; Kyle R Crow; Keith R Buszek
Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis.
Bioorganic & medicinal chemistry letters 2008;18(17):4876-9.
2008: Neil Brown; Ge Gao; Machiko Minatoya; Baohan Xie; David VanderVelde; Gerald H Lushington; Jean-Pierre H Perchellet; Elisabeth M Perchellet; Kyle R Crow; Keith R Buszek
Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach.
Journal of combinatorial chemistry 2008;10(5):628-31.
2008: Duy H Hua; Huiping Zhao; Srinivas K Battina; Kaiyan Lou; Ana L Jimenez; John Desper; Elisabeth M Perchellet; Jean-Pierre H Perchellet; Peter K Chiang
Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities.
Bioorganic & medicinal chemistry 2008;16(9):5232-46.
2007: Elisabeth M Perchellet; Yang Wang; Kaiyan Lou; Huiping Zhao; Srinivas K Battina; Duy H Hua; Jean-Pierre H Perchellet
Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria.
International journal of oncology 2007;31(5):1231-41.
2007: Elisabeth M Perchellet; Yang Wang; Kaiyan Lou; Huiping Zhao; Srinivas K Battina; Duy H Hua; Jean-Pierre H Perchellet
Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.
Anticancer research 2007;27(5A):3259-71.
2006: Elisabeth M Perchellet; Mary M Ward; Alexios-Leandros Skaltsounis; Ioannis K Kostakis; Nicole Pouli; Panagiotis Marakos; Jean-Pierre H Perchellet
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells.
Anticancer research 2006;26(4B):2791-804.
2006: Duy H Hua; Kaiyan Lou; Srinivas K Battina; Huiping Zhao; Elisabeth M Perchellet; Yang Wang; Jean-Pierre H Perchellet
Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs.
Anti-cancer agents in medicinal chemistry 2006;6(4):303-18.
2006: Yang Wang; Elisabeth M Perchellet; Mary M Ward; Kaiyan Lou; Huiping Zhao; Srinivas K Battina; Bernard Wiredu; Duy H Hua; Jean-Pierre H Perchellet
Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria.
International journal of oncology 2006;28(1):161-72.
2005: Yang Wang; Elisabeth M Perchellet; Mary M Ward; Kaiyan Lou; Duy H Hua; Jean-Pierre H Perchellet
Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.
Anti-cancer drugs 2005;16(9):953-67.
2005: Elisabeth M Perchellet; Jean-Pierre H Perchellet; Paul W Baures
Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells.
Journal of medicinal chemistry 2005;48(19):5955-65.
2004: Elisabeth M Perchellet; Yang Wang; Rebeka L Weber; Kaiyan Lou; Duy H Hua; Jean-Pierre H Perchellet
Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.
Anti-cancer drugs 2004;15(10):929-46.
2004: Duy H Hua; Xiaodong Huang; Yi Chen; Srinivas K Battina; Masafumi Tamura; Sang K Noh; Sung I Koo; Ichiji Namatame; Hiroshi Tomoda; Elisabeth M Perchellet; Jean-Pierre H Perchellet
Total syntheses of (+)-chloropuupehenone and (+)-chloropuupehenol and their analogues and evaluation of their bioactivities.
The Journal of organic chemistry 2004;69(18):6065-78.
2004: Elisabeth M Perchellet; Yang Wang; Rebeka L Weber; Bonnie J Sperfslage; Kaiyan Lou; Justin Crossland; Duy H Hua; Jean-Pierre H Perchellet
Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.
Biochemical pharmacology 2004;67(3):523-37.
2003: Buna Wang; Elisabeth M Perchellet; Yang Wang; Masafumi Tamura; Duy H Hua; Jean-Pierre H Perchellet
Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.
Anti-cancer drugs 2003;14(7):503-14.
2002: Yang Wang; Elisabeth M Perchellet; Masafumi Tamura; Duy H Hua; Jean-Pierre H Perchellet
Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines.
Cancer letters 2002;188(1-2):73-83.
2002: Elisabeth M Perchellet; Bonnie J Sperfslage; Yang Wang; Xiaodong Huang; Masafumi Tamura; Duy H Hua; Jean-Pierre H Perchellet
Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.
Anti-cancer drugs 2002;13(6):567-81.
2002: Duy H Hua; Masafumi Tamura; Xiaodong Huang; Heidi A Stephany; Brian A Helfrich; Elisabeth M Perchellet; Bonnie J Sperfslage; Jean-Pierre H Perchellet; Suping Jiang; Dennis E Kyle; Peter K Chiang
Syntheses and bioactivities of substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetrones. Unusual reactivities with amines.
The Journal of organic chemistry 2002;67(9):2907-12.
2002: Nectarios Algiannis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Jean-Claude Florent; Elisabeth M Perchellet; Bonnie J Sperfslage; Corbin J McIlvain; Jean-Pierre H Perchellet
Preparation and cytotoxic activity of some new rhodomycin derivatives bearing modifications in the sugar moiety.
The Journal of antibiotics 2002;55(2):181-90.
2001: Buna Wang; M Wu; Elisabeth M Perchellet; Corbin J McIlvain; Bonnie J Sperfslage; Xiaodong Huang; Masafumi Tamura; Heidi A Stephany; Duy H Hua; Jean-Pierre H Perchellet
A synthetic triptycene bisquinone, which blocks nucleoside transport and induces DNA fragmentation, retains its cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines.
International journal of oncology 2001;19(6):1169-78.
2001: Elisabeth M Perchellet; Bonnie J Sperfslage; Corbin J McIlvain; Nektarios Aligiannis; Nicole Pouli; Panagiotis Marakos; Alexios-Leandros Skaltsounis; Jean-Pierre H Perchellet
Antileukemic activity of synthetic daunomycinone derivatives bearing modifications in the glycosidic moiety.
Anticancer research 2001;21(6A):3957-67.
2001: M Wu; Buna Wang; Elisabeth M Perchellet; Bonnie J Sperfslage; Heidi A Stephany; Duy H Hua; Jean-Pierre H Perchellet
Synthetic 1,4-anthracenediones, which block nucleoside transport and induce DNA fragmentation, retain their cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines.
Anti-cancer drugs 2001;12(10):807-19.
2001: Elisabeth M Perchellet; Bonnie J Sperfslage; Ghassan Qabaja; Graham B Jones; Jean-Pierre H Perchellet
Quinone isomers of the WS-5995 antibiotics: synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation, and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro.
Anti-cancer drugs 2001;12(5):401-17.
2000: Elisabeth M Perchellet; MJ Magill; Xiaodong Huang; D M Dalke; Duy H Hua; Jean-Pierre H Perchellet
1,4-Anthraquinone: an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro.
Anti-cancer drugs 2000;11(5):339-52.
1999: Duy H Hua; Yi Chen; H S Sin; Paul D Robinson; Cal Y Meyers; Elisabeth M Perchellet; Jean-Pierre H Perchellet; Peter K Chiang; J F Biellmann
6,7,8,9-Tetrahydro-3-methyl-1H-pyrano-[4,3-b]quinolin-1-one.
Acta crystallographica. Section C, Crystal structure communications 1999;55 ( Pt 10)():1698-701.
1999: Elisabeth M Perchellet; MJ Magill; Xiaodong Huang; C E Brantis; Duy H Hua; Jean-Pierre H Perchellet
Triptycenes: a novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro.
Anti-cancer drugs 1999;10(8):749-66.
1999: Elisabeth M Perchellet; JB Ladesich; MJ Magill; Yi Chen; Duy H Hua; Jean-Pierre H Perchellet
Tricyclic pyrone analogs: a new synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro and the growth of solid tumors in vivo.
Anti-cancer drugs 1999;10(5):489-504.
1999: Elisabeth M Perchellet; JB Ladesich; P Collery; Jean-Pierre H Perchellet
Microtubule-disrupting effects of gallium chloride in vitro.
Anti-cancer drugs 1999;10(5):477-88.
1999: SW Newell; Jean-Pierre H Perchellet; Elisabeth M Perchellet; ET Ulug
Alterations in focal adhesion kinase activity and associated proteins during malignant conversion of mouse keratinocytes.
Molecular carcinogenesis 1999;25(1):73-83.
1998: Elisabeth M Perchellet; JB Ladesich; Yi Chen; H S Sin; Duy H Hua; Susan L Kraft; Jean-Pierre H Perchellet
Antitumor activity of tricyclic pyrone analogs, a new synthetic class of microtubule de-stabilizing agents, in the murine EMT-6 mammary tumor cell line in vitro.
Anti-cancer drugs 1998;9(6):565-76.
1998: SW Newell; Elisabeth M Perchellet; JB Ladesich; J A Freeman; Yi Chen; L Liu; Duy H Hua; Susan L Kraft; Randall J Basaraba; Jean-Pierre H Perchellet
Tricyclic pyrone analogs: a new class of microtubule-disrupting anticancer drugs effective against murine leukemia cells in vitro.
International journal of oncology 1998;12(2):433-42.
1998: Jean-Pierre H Perchellet; Elisabeth M Perchellet; SW Newell; J A Freeman; JB Ladesich; Y Jeong; N Sato; Keith R Buszek
Antitumor activity of novel octalactin A analogs in murine leukemia cells in vitro.
Anticancer research 1998;18(1A):97-106.
1997: Jean-Pierre H Perchellet; SW Newell; JB Ladesich; Elisabeth M Perchellet; Yi Chen; Duy H Hua; Susan L Kraft; Randall J Basaraba; S Omura; Hiroshi Tomoda
Antitumor activity of novel tricyclic pyrone analogs in murine leukemia cells in vitro.
Anticancer research 1997;17(4A):2427-34.
1996: X M Gao; Elisabeth M Perchellet; A W Davis; SW Newell; G Chen; Duy H Hua; Jean-Pierre H Perchellet
Camptothecin post-treatments inhibit the biochemical events linked to the tumor-promoting component of carcinogenesis in mouse epidermis in vivo.
International journal of cancer. Journal international du cancer 1996;66(4):496-505.
1996: X M Gao; Elisabeth M Perchellet; A W Davis; SW Newell; Duy H Hua; Jean-Pierre H Perchellet
Characterization of the antitumor-promoting activity of camptothecin in SENCAR mouse skin.
Carcinogenesis 1996;17(5):1141-8.
1996: SW Newell; Elisabeth M Perchellet; X M Gao; G Chen; Jean-Pierre H Perchellet
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Cancer letters 1996;98(2):241-51.
1995: G Chen; Elisabeth M Perchellet; X M Gao; SW Newell; R W Hemingway; V Bottari; Jean-Pierre H Perchellet
Ability of m-chloroperoxybenzoic acid to induce the ornithine decarboxylase marker of skin tumor promotion and inhibition of this response by gallotannins, oligomeric proanthocyanidins, and their monomeric units in mouse epidermis in vivo.
Anticancer research 1995;15(4):1183-9.
1994: H U Gali; Elisabeth M Perchellet; X M Gao; J J Karchesy; Jean-Pierre H Perchellet
Comparison of the inhibitory effects of monomeric, dimeric, and trimeric procyanidins on the biochemical markers of skin tumor promotion in mouse epidermis in vivo.
Planta medica 1994;60(3):235-9.
1993: Elisabeth M Perchellet; H U Gali; X M Gao; Jean-Pierre H Perchellet
Ability of the non-phorbol ester-type tumor-promoter thapsigargin to mimic the stimulatory effects of 12-0-tetradecanoylphorbol-13-acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis in vivo.
International journal of cancer. Journal international du cancer 1993;55(6):1036-43.
1993: H U Gali; Elisabeth M Perchellet; X M Gao; P E Laks; Jean-Pierre H Perchellet
Inhibitory effects of semisynthetic flavonoid derivatives on the biochemical markers of tumor promotion in mouse epidermis in vivo.
Cancer letters 1993;72(3):149-56.
1993: H U Gali; Elisabeth M Perchellet; X M Gao; V Bottari; Jean-Pierre H Perchellet
Antitumor-promoting effects of gallotannins extracted from various sources in mouse skin in vivo.
Anticancer research 1993;13(4):915-22.
1992: K Satyamoorthy; Elisabeth M Perchellet; Jean-Pierre H Perchellet
Effects of adriamycin and daunomycin on ornithine decarboxylase activity and DNA synthesis in mouse epidermal cells.
Toxicology in vitro : an international journal published in association with BIBRA 1992;6(5):459-63.
1992: H U Gali; Elisabeth M Perchellet; D S Klish; J M Johnson; Jean-Pierre H Perchellet
Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate in vivo.
International journal of cancer. Journal international du cancer 1992;51(3):425-32.
1992: H U Gali; Elisabeth M Perchellet; D S Klish; J M Johnson; Jean-Pierre H Perchellet
Antitumor-promoting activities of hydrolyzable tannins in mouse skin.
Carcinogenesis 1992;13(4):715-8.
1992: Jean-Pierre H Perchellet; H U Gali; Elisabeth M Perchellet; D S Klish; A D Armbrust
Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin.
Basic life sciences 1992;59():783-801.
1991: H U Gali; Elisabeth M Perchellet; Jean-Pierre H Perchellet
Inhibition of tumor promoter-induced ornithine decarboxylase activity by tannic acid and other polyphenols in mouse epidermis in vivo.
Cancer research 1991;51(11):2820-5.
1990: Elisabeth M Perchellet; D Jones; Jean-Pierre H Perchellet
Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo.
Cancer research 1990;50(18):5806-12.
1990: Jean-Pierre H Perchellet; Elisabeth M Perchellet; S Belman
Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils.
Nutrition and cancer 1990;14(3-4):183-93.
1989: Elisabeth M Perchellet; Jean-Pierre H Perchellet
Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo.
Cancer research 1989;49(22):6193-201.
1989: Jean-Pierre H Perchellet; Elisabeth M Perchellet
Antioxidants and multistage carcinogenesis in mouse skin.
Free radical biology & medicine 1989;7(4):377-408.
1988: Elisabeth M Perchellet; N L Abney; Jean-Pierre H Perchellet
Stimulation of hydroperoxide generation in mouse skins treated with tumor-promoting or carcinogenic agents in vivo and in vitro.
Cancer letters 1988;42(3):169-77.
1987: Jean-Pierre H Perchellet; N L Abney; R M Thomas; Elisabeth M Perchellet; E A Maatta
Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate.
Cancer research 1987;47(23):6302-9.
1987: Elisabeth M Perchellet; E A Maatta; N L Abney; Jean-Pierre H Perchellet
Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate.
Journal of cellular physiology 1987;131(1):64-73.
1987: Jean-Pierre H Perchellet; N L Abney; R M Thomas; Y L Guislain; Elisabeth M Perchellet
Effects of combined treatments with selenium, glutathione, and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction, and complete and multistage carcinogenesis in mouse skin.
Cancer research 1987;47(2):477-85.
1986: Jean-Pierre H Perchellet; Elisabeth M Perchellet; N L Abney; J A Zirnstein; S Belman
Effects of garlic and onion oils on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione and ornithine decarboxylase induction in isolated mouse epidermal cells treated with tumor promoters.
Cancer biochemistry biophysics 1986;8(4):299-312.
1986: Jean-Pierre H Perchellet; Elisabeth M Perchellet; D K Orten; B A Schneider
Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters.
Carcinogenesis 1986;7(3):503-6.
1985: Jean-Pierre H Perchellet; G S Kishore; Elisabeth M Perchellet
Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion.
Cancer letters 1985;29(2):127-37.
1985: Jean-Pierre H Perchellet; Elisabeth M Perchellet; D K Orten; B A Schneider
Inhibition of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds.
Cancer letters 1985;26(3):283-93.