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Ralph Bernacki
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25
Pera, Paula
19
Ojima, Iwao
8
Porter, Carl
7
Veith, Jean
5
Sufrin, Janice
5
Baer, Maria
5
Bergeron, Raymond
5
Dimitroff, Charles
5
Geng, Xudong
5
Greco, William
4
Brooks, Tracy
4
Kramer, Debora
4
Matta, Khushi
4
Sun, Liang
3
Horwitz, Susan B.
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All Publications
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2008: Sun Liang; Geng Xudong; Geney Raphaël; Li Yuan; Simmerling Carlos; Li Zhong; Lauher Joseph W; Xia Shujun; Horwitz Susan B; Veith Jean M; Pera Paula; Bernacki Ralph J; Ojima Iwao
Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.
The Journal of organic chemistry 2008;73(24):9584-93.
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2008: Ojima Iwao; Chen Jin; Sun Liang; Borella Christopher P; Wang Tao; Miller Michael L; Lin Songnian; Geng Xudong; Kuznetsova Larisa; Qu Chuanxing; Gallager David; Zhao Xianrui; Zanardi Ilaria; Xia Shujun; Horwitz Susan B; Mallen-St Clair Jon; Guerriero Jennifer L; Bar-Sagi Dafna; Veith Jean M; Pera Paula; Bernacki Ralph J
Design, synthesis, and biological evaluation of new-generation taxoids.
Journal of medicinal chemistry 2008;51(11):3203-21.
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2008: Bernacki Ralph J
Metronomic chemotherapy and tumor immunomodulation.
Cancer biology & therapy 2008;7(4):602.
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2007: Brun Yseult F; Dennis Carly G; Greco William R; Bernacki Ralph J; Pera Paula J; Bushey Jennifer J; Youn Richard C; White Donald B; Segal Brahm H
Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm.
Antimicrobial agents and chemotherapy 2007;51(5):1804-12.
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2007: Brooks Tracy A; O'Loughlin Kieran L; Minderman Hans; Bundy Brian N; Ford Laurie A; Vredenburg Michael R; Bernacki Ralph J; Priebe Waldemar; Baer Maria R
The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells.
Investigational new drugs 2007;25(2):115-22.
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2006: Dennis Carly G; Greco William R; Brun Yseult; Youn Richard; Slocum Harry K; Bernacki Ralph J; Lewis Russell; Wiederhold Nathan; Holland Steven M; Petraitiene Ruta; Walsh Thomas J; Segal Brahm H
Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.
Antimicrobial agents and chemotherapy 2006;50(2):422-7.
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2006: Kuznetsova Larissa; Chen Jin; Sun Liang; Wu Xinyuan; Pepe Antonella; Veith Jean M; Pera Paula; Bernacki Ralph J; Ojima Iwao
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents.
Bioorganic & medicinal chemistry letters 2006;16(4):974-7.
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2005: Bouvet Michael; Spernyak Joseph; Katz Matthew H; Mazurchuk Richard V; Takimoto Shinako; Bernacki Ralph; Rustum Youcef M; Moossa Abdool R; Hoffman Robert M
High correlation of whole-body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer.
Cancer research 2005;65(21):9829-33.
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2005: Geney Raphaël; Sun Liang; Pera Paula; Bernacki Ralph J; Xia Shujun; Horwitz Susan B; Simmerling Carlos L; Ojima Iwao
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design.
Chemistry & biology 2005;12(3):339-48.
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2005: Ojima Iwao; Borella Christopher P; Wu Xinyuan; Bounaud Pierre-Yves; Oderda Cecilia Fumero; Sturm Matthew; Miller Michael L; Chakravarty Subrata; Chen Jin; Huang Qing; Pera Paula; Brooks Tracy A; Baer Maria R; Bernacki Ralph J
Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents.
Journal of medicinal chemistry 2005;48(6):2218-28.
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2005: Marasco Canio J; Pera Paula J; Spiess Arthur J; Bernacki Ralph; Sufrin Janice R
Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers.
Molecules (Basel, Switzerland) 2005;10(8):1015-20.
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2004: Geng Xudong; Geney Raphaël; Pera Paula; Bernacki Ralph J; Ojima Iwao
Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton.
Bioorganic & medicinal chemistry letters 2004;14(13):3491-4.
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2004: El-Araby Moustafa E; Bernacki Ralph J; Makara Gergely M; Pera Paula J; Anderson Wayne K
Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid.
Bioorganic & medicinal chemistry 2004;12(11):2867-79.
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2004: Minderman Hans; Brooks Tracy A; O'Loughlin Kieran L; Ojima Iwao; Bernacki Ralph J; Baer Maria R
Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.
Cancer chemotherapy and pharmacology 2004;53(5):363-9.
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2004: Ling Xiang; Bernacki Ralph J; Brattain Michael G; Li Fengzhi
Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G2/M arrest.
The Journal of biological chemistry 2004;279(15):15196-203.
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2004: Brooks Tracy A; Kennedy Daniel R; Gruol Donald J; Ojima Iwao; Baer Maria R; Bernacki Ralph J
Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators.
Anticancer research 2004;24(2A):409-15.
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2004: Appendino Giovanni; Bettoni Piergiorgio; Noncovich Alain; Sterner Olov; Fontana Gabriele; Bombardelli Ezio; Pera Paula; Bernacki Ralph J
Structure-activity relationships of ring C-secotaxoids. 1. Acylative modifications.
Journal of natural products 2004;67(2):184-8.
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2004: Ramnath N; Hamm J; Schwartz G; Holden S; Eckhardt S G; Vredenburg M R; Bernacki R J; Lathia C; Kanter P; Creaven P J
A phase I and pharmacokinetic study of BAY59: a novel taxane.
Oncology 2004;67(2):123-9.
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2003: Brooks Tracy A; Minderman Hans; O'Loughlin Kieran L; Pera Paula; Ojima Iwao; Baer Maria R; Bernacki Ralph J;
Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
Molecular cancer therapeutics 2003;2(11):1195-205.
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2003: Battaglia Arturo; Bernacki Ralph J; Bertucci Carlo; Bombardelli Ezio; Cimitan Samanta; Ferlini Cristiano; Fontana Gabriele; Guerrini Andrea; Riva Antonella
Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate.
Journal of medicinal chemistry 2003;46(23):4822-5.
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2003: Wu Ming; Mazurchuk Richard; Chaudhary Neeta D; Spernyak Joseph; Veith Jean; Pera Paula; Greco William; Hoffman Robert M; Kobayashi Tomowo; Bernacki Ralph J
High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model.
Cancer research 2003;63(10):2477-82.
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2003: Dimitroff Charles J; Bernacki Ralph J; Sackstein Robert
Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin.
Blood 2003;101(2):602-10.
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2002: Marasco Canio J; Kramer Debora L; Miller John; Porter Carl W; Bacchi Cyrus J; Rattendi Donna; Kucera Louis; Iyer Nathan; Bernacki Ralph; Pera Paula; Sufrin Janice R
Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity.
Journal of medicinal chemistry 2002;45(23):5112-22.
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2002: Leontieva Olga V; Preobrazhenskaya Maria N; Bernacki Ralph J
Partial circumvention of P-glycoprotein-mediated multidrug resistance by doxorubicin-14-O-hemiadipate.
Investigational new drugs 2002;20(1):35-48.
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2002: Ojima Iwao; Geng Xudong; Lin Songnian; Pera Paula; Bernacki Ralph J
Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids.
Bioorganic & medicinal chemistry letters 2002;12(3):349-52.
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2001: Chibale K; Ojima I; Haupt H; Geng X; Pera P; Bernacki R J
Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides.
Bioorganic & medicinal chemistry letters 2001;11(18):2457-60.
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2001: Vredenburg M R; Ojima I; Veith J; Pera P; Kee K; Cabral F; Sharma A; Kanter P; Greco W R; Bernacki R J
Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance.
Journal of the National Cancer Institute 2001;93(16):1234-45.
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2001: Gruol D J; Bernd J; Phippard A E; Ojima I; Bernacki R J
The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel.
Molecular pharmacology 2001;60(1):104-13.
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2000: Ojima I; Lin S; Slater J C; Wang T; Pera P; Bernacki R J; Ferlini C; Scambia G
Syntheses and biological activity of C-3'-difluoromethyl-taxoids.
Bioorganic & medicinal chemistry 2000;8(7):1619-28.
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2000: Bernacki R J; Pera P; Gambacorta P; Brun Y; Greco W R
In vitro antitumor activity of 9-nitro-camptothecin as a single agent and in combination with other antitumor drugs.
Annals of the New York Academy of Sciences 2000;922():293-7.
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1999: Ojima I; Wang T; Miller M L; Lin S; Borella C P; Geng X; Pera P; Bernacki R J
Synthesis and structure-activity relationships of new second-generation taxoids.
Bioorganic & medicinal chemistry letters 1999;9(24):3423-8.
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1999: Dimitroff C J; Pera P; Dall'Olio F; Matta K L; Chandrasekaran E V; Lau J T; Bernacki R J
Cell surface n-acetylneuraminic acid alpha2,3-galactoside-dependent intercellular adhesion of human colon cancer cells.
Biochemical and biophysical research communications 1999;256(3):631-6.
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1999: Dimitroff C J; Klohs W; Sharma A; Pera P; Driscoll D; Veith J; Steinkampf R; Schroeder M; Klutchko S; Sumlin A; Henderson B; Dougherty T J; Bernacki R J
Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy.
Investigational new drugs 1999;17(2):121-35.
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1998: Ojima I; Bounaud P Y; Takeuchi C; Pera P; Bernacki R J
New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
Bioorganic & medicinal chemistry letters 1998;8(2):189-94.
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1998: Mi Z; Kramer D L; Miller J T; Bergeron R J; Bernacki R; Porter C W
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors.
The Prostate 1998;34(1):51-60.
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1998: Dimitroff C J; Sharma A; Bernacki R J
Cancer metastasis: a search for therapeutic inhibition.
Cancer investigation 1998;16(4):279-90.
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1997: Kramer D L; Fogel-Petrovic M; Diegelman P; Cooley J M; Bernacki R J; McManis J S; Bergeron R J; Porter C W
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
Cancer research 1997;57(24):5521-7.
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1997: Sharma A; Glaves D; Porter C W; Raghavan D; Bernacki R J
Antitumor efficacy of N1,N11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(8):1239-44.
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1997: Sharma A; Mayhew E; Bolcsak L; Cavanaugh C; Harmon P; Janoff A; Bernacki R J
Activity of paclitaxel liposome formulations against human ovarian tumor xenografts.
International journal of cancer. Journal international du cancer 1997;71(1):103-7.
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1997: Ojima I; Kuduk S D; Pera P; Veith J M; Bernacki R J
Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity.
Journal of medicinal chemistry 1997;40(3):279-85.
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1997: Ojima I; Slater J C; Kuduk S D; Takeuchi C S; Gimi R H; Sun C M; Park Y H; Pera P; Veith J M; Bernacki R J
Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.
Journal of medicinal chemistry 1997;40(3):267-78.
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1997: Sharma A; Bernacki R J
Ovarian cancer patients with high CA-125 but no symptoms--should antiangiogenic treatments be considered?
Oncology research 1997;9(2):53-4.
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1996: Ojima I; Slater J C; Michaud E; Kuduk S D; Bounaud P Y; Vrignaud P; Bissery M C; Veith J M; Pera P; Bernacki R J
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
Journal of medicinal chemistry 1996;39(20):3889-96.
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1996: Woynarowska B; Dimitroff C J; Sharma M; Matta K L; Bernacki R J
Inhibition of human HT-29 colon carcinoma cell adhesion by a 4-fluoro-glucosamine analogue.
Glycoconjugate journal 1996;13(4):663-74.
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1995: Sharma A; Straubinger R M; Ojima I; Bernacki R J
Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice.
Journal of pharmaceutical sciences 1995;84(12):1400-4.
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1995: Angelino N J; Bernacki R J; Sharma M; Dodson-Simmons O; Korytnyk W
Versatile intermediates in the selective modification of the amino function of 2-amino-2-deoxy-D-mannopyranose and the 3-position of 2-acetamido-2-deoxy-D-mannose: potential membrane modifiers in neoplastic control.
Carbohydrate research 1995;276(1):99-115.
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1995: Bernacki R J; Oberman E J; Seweryniak K E; Atwood A; Bergeron R J; Porter C W
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):847-57.
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1994: Woynarowska B; Skrincosky D M; Haag A; Sharma M; Matta K; Bernacki R J
Inhibition of lectin-mediated ovarian tumor cell adhesion by sugar analogs.
The Journal of biological chemistry 1994;269(36):22797-803.
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1994: Ojima I; Park Y H; Sun C M; Fenoglio I; Appendino G; Pera P; Bernacki R J
Structure-activity relationships of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.
Journal of medicinal chemistry 1994;37(10):1408-10.
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1994: Chandrasekaran E V; Rhodes J M; Jain R K; Bernacki R J; Matta K L
A biosynthetic control on structures serving as ligands for selectins: the precursor structures, 3-sialyl/sulfo Gal beta 1, 3/4GlcNAc beta-0-R, which are high affinity substrates for alpha 1, 3/4-L-fucosyltransferases, exhibit the phenomenon of substrate inhibition.
Biochemical and biophysical research communications 1994;201(1):78-89.
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1993: Skrincosky D M; Allen H J; Bernacki R J
Galaptin-mediated adhesion of human ovarian carcinoma A121 cells and detection of cellular galaptin-binding glycoproteins.
Cancer research 1993;53(11):2667-75.
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1993: Tumminello F M; Bernacki R J; Gebbia N; Leto G
Pepstatins: aspartic proteinase inhibitors having potential therapeutic applications.
Medicinal research reviews 1993;13(2):199-208.
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1993: Sharma M; Bernacki R J; Hillman M J; Korytnyk W
Fluorinated carbohydrates as potential plasma membrane modifiers. Synthesis of 3-deoxy-3-fluoro derivatives of 2-acetamido-2-deoxy-D-hexopyranoses.
Carbohydrate research 1993;240():85-93.
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1993: Porter C W; Bernacki R J; Miller J; Bergeron R J
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Cancer research 1993;53(3):581-6.
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1992: Bernacki R J; Bergeron R J; Porter C W
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Cancer research 1992;52(9):2424-30.
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1992: Woynarowska B; Wikiel H; Sharma M; Carpenter N; Fleet G W; Bernacki R J
Inhibition of human ovarian carcinoma cell- and hexosaminidase- mediated degradation of extracellular matrix by sugar analogs.
Anticancer research 1992;12(1):161-6.
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1991: Sufrin J R; Spiess A J; Kramer D L; Libby P R; Miller J T; Bernacki R J; Lee Y H; Borchardt R T; Porter C W
Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.
Journal of medicinal chemistry 1991;34(8):2600-6.
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1991: Weiss L; Bernacki R J; Elkin G; Hillman M
Effects of doxorubicin on the sensitivity of L1210 leukemia cells to deformation-associated trauma.
Cell biophysics 1991;18(1):57-67.
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1990: Sharma M; Bernacki R J; Paul B; Korytnyk W
Fluorinated carbohydrates as potential plasma membrane modifiers. Synthesis of 4- and 6-fluoro derivatives of 2-acetamido-2-deoxy-D-hexopyranoses.
Carbohydrate research 1990;198(2):205-21.
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1990: Allen H J; Sucato D; Woynarowska B; Gottstine S; Sharma A; Bernacki R J
Role of galaptin in ovarian carcinoma adhesion to extracellular matrix in vitro.
Journal of cellular biochemistry 1990;43(1):43-57.
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1990: Morreal C E; Bernacki R J; Hillman M; Atwood A; Cartonia D
Antitumor properties of tetrahydrobenz[a]anthraquinone derivatives.
Journal of medicinal chemistry 1990;33(2):490-2.
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1990: Leto G; Tumminello F M; Gebbia N; Woynarowska B; Bernacki R J
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Anticancer research 1990;10(1):265-9.
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1989: Woynarowska B; Wikiel H; Bernacki R J
Human ovarian carcinoma beta-N-acetylglucosaminidase isoenzymes and their role in extracellular matrix degradation.
Cancer research 1989;49(20):5598-604.
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1989: Tumminello F M; Leto G; Gebbia N; Rausa L; Bernacki R J
Evaluation of antitumor and antimetastatic activity of pepstatin A in some experimental tumor models.
Journal of chemotherapy (Florence, Italy) 1989;1(4 Suppl):1135-8.
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1989: Bobek M; An S H; Skrincosky D; De Clercq E; Bernacki R J
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Journal of medicinal chemistry 1989;32(4):799-807.
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1989: Crickard K; Niedbala M J; Crickard U; Yoonessi M; Sandberg A A; Okuyama K; Bernacki R J; Satchidanand S K
Characterization of human ovarian and endometrial carcinoma cell lines established on extracellular matrix.
Gynecologic oncology 1989;32(2):163-73.
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1988: Lee H H; Hodgson P G; Bernacki R J; Korytnyk W; Sharma M
Analogs of cell surface carbohydrates. Synthesis of D-galactose derivatives having an ethynyl, vinyl or epoxy residue at C-5.
Carbohydrate research 1988;176(1):59-72.
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1987: Niedbala M J; Madiyalakan R; Matta K; Crickard K; Sharma M; Bernacki R J
Role of glycosidases in human ovarian carcinoma cell mediated degradation of subendothelial extracellular matrix.
Cancer research 1987;47(17):4634-41.
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1987: Bobek M; An S H; Skrincosky D; De Clerq E; Bernacki R J
2'-fluorinated pyrimidine isonucleosides. Novel nucleoside analogs demonstrate therapeutic activity in mice with tumors.
Nucleic acids symposium series 1987;(18):5-7.
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1986: Bulbul M A; Pavelic K; Slocum H K; Frankfurt O S; Rustum Y M; Huben R P; Bernacki R J
Growth of human urologic tumors on extracellular matrix.
The Journal of urology 1986;136(2):512-6.
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1986: Pavelic K; Bulbul M A; Slocum H K; Pavelic Z P; Rustum Y M; Niedbala M J; Bernacki R J
Growth of human urological tumors on extracellular matrix as a model for the in vitro cultivation of primary human tumor explants.
Cancer research 1986;46(7):3653-62.
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1985: Bernacki R J; Wilson G L; Mossman B T; Angelino N; Kanter P M; Korytnyk W
Therapeutic and diabetogenic potential of two newly synthesized nitrosoureido sugars.
Cancer research 1985;45(2):695-702.
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1985: Bernacki R J; Niedbala M J; Korytnyk W
Glycosidases in cancer and invasion.
Cancer metastasis reviews 1985;4(1):81-101.
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1983: Morin M J; Bernacki R J
Biochemical effects and therapeutic potential of tunicamycin in murine L1210 leukemia.
Cancer research 1983;43(4):1669-74.
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1983: Morin M J; Porter C W; Petrie C R; Korytnyk W; Bernacki R J
Effects of a membrane sugar analogue, 6-deoxy-6-fluoro-D-galactose, on the L1210 leukemic cell ectosialyltransferase system.
Biochemical pharmacology 1983;32(3):553-61.
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1983: Morin M J; Porter C W; McKernan P; Bernacki R J
The biochemical and ultrastructural effects of tunicamycin and D-glucosamine in L1210 leukemic cells.
Journal of cellular physiology 1983;114(2):162-72.
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1982: Korytnyk W; Sufrin J R; Bernacki R J
Alternative syntheses of 2,6-dideoxy-L-lyxo-hexose (2-deoxy-L-fucose) and its biochemical properties.
Carbohydrate research 1982;103(1):170-5.
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1980: Paul B; Bernacki R J; Korytnyk W
Synthesis and biological activity of some 1-N-substituted 2-acetamido-2-deoxy-beta-D-glycopyranosylamine derivatives and related analogs.
Carbohydrate research 1980;80(1):99-115.
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1980: Sufrin J R; Bernacki R J; Morin M J; Korytnyk W
Halogenated L-fucose and D-galactose analogues: synthesis and metabolic effects.
Journal of medicinal chemistry 1980;23(2):143-9.
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