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José Pérez
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38
Alonso, Carlos
25
Fuertes, Miguel
25
Navarro-Ranninger, Carmen
12
González, Víctor
11
Montero, Eva
8
Quiroga, Adoracion
7
López-Solera, Isabel
6
Nguewa, Paul
6
Moreno, Virtudes
5
Cepeda, Victoria
4
Prieto, Maria
4
Solans, Xavier
3
Soto, Manuel
3
Souza, Pilar
3
Valladares, Basilio
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All Publications
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2008: Fuertes Miguel A; Nguewa Paul A; Castilla Josefina; Alonso Carlos; Pérez José M
Anticancer compounds as leishmanicidal drugs: challenges in chemotherapy and future perspectives.
Current medicinal chemistry 2008;15(5):433-9.
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2007: Cepeda Victoria; Fuertes Miguel A; Castilla Josefina; Alonso Carlos; Quevedo Celia; Pérez Jose M
Biochemical mechanisms of cisplatin cytotoxicity.
Anti-cancer agents in medicinal chemistry 2007;7(1):3-18.
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2006: García-Friaza Gloria; Fernández-Botello Alfonso; Pérez Jose M; Prieto Maria J; Moreno Virtudes
Synthesis and characterization of palladium(II) and platinum(II) complexes with Schiff bases derivatives of 2-pyridincarboxyaldehyde. Study of their interaction with DNA.
Journal of inorganic biochemistry 2006;100(8):1368-77.
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2006: Fuertes Miguel A; Cepeda Victoria; Alonso Carlos; Pérez José M
Molecular mechanisms for the B-Z transition in the example of poly[d(G-C) x d(G-C)] polymers. A critical review.
Chemical reviews 2006;106(6):2045-64.
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2006: Gay Marina; Montaña Angel M; Moreno Virtudes; Prieto María-José; Pérez José Manuel; Alonso Carlos
Studies of interaction of trichloro{eta2-cis-N,N-dimethyl-1-[6-(N',N'-dimethyl-ammoniummethyl)-cyclohex-3-ene-1-yl]-methylammonium}platinum(II) chloride with DNA: Effects on secondary and tertiary structures of DNA. Cytotoxic assays on human ovarian cancer cell lines, resistant and non-resistant to cisplatin.
Bioorganic & medicinal chemistry 2006;14(5):1565-72.
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2006: Cepeda Victoria; Fuertes Miguel A; Castilla Josefina; Alonso Carlos; Quevedo Celia; Soto Manual; Pérez José M
Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors in cancer chemotherapy.
Recent patents on anti-cancer drug discovery 2006;1(1):39-53.
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2006: Nguewa Paul A; Fuertes Miguel A; Cepeda Victoria; Alonso Carlos; Quevedo Celia; Soto Manuel; Pérez José M
Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2006;2(1):47-53.
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2006: Quiroga Adoración G; Pérez Jose M; Alonso Carlos; Navarro-Ranninger Carmen; Farrell Nicholas
Novel transplatinum(II) complexes with [N2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells.
Journal of medicinal chemistry 2006;49(1):224-31.
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2005: Nguewa Paul A; Fuertes Miguel A; Cepeda Victoria; Iborra Salvador; Carrión Javier; Valladares Basilio; Alonso Carlos; Pérez José M
Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin.
Chemistry & biodiversity 2005;2(10):1387-400.
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2005: Nguewa Paul A; Fuertes Miguel A; Valladares Basilio; Alonso Carlos; Pérez José M
Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
Progress in biophysics and molecular biology 2005;88(1):143-72.
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2005: Nguewa Paul A; Fuertes Miguel A; Iborra Salvador; Najajreh Yousef; Gibson Dani; Martínez Enrique; Alonso Carlos; Pérez José M
Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum.
Journal of inorganic biochemistry 2005;99(3):727-36.
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2004: Manzanaro Sonia; Vicent María Jesús; Martín María Jesús; Salvador-Tormo Nélida; Pérez José María; del Mar Blanco María; Avendaño Carmen; Menéndez José Carlos; de la Fuente Jesús Angel
Synthesis and biological evaluation of new 1,5-diazaanthraquinones with cytotoxic activity.
Bioorganic & medicinal chemistry 2004;12(24):6505-15.
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2004: Nguewa Paul A; Fuertes Miguel A; Valladares Basilio; Alonso Carlos; Pérez José M
Programmed cell death in trypanosomatids: a way to maximize their biological fitness?
Trends in parasitology 2004;20(8):375-80.
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2004: Avendaño Carmen; Pérez José María; Blanco Maria del Mar; de la Fuente Jesús Angel; Manzanaro Sonia; Vicent María Jesús; Martín María Jesús; Salvador-Tormo Nélida; Menéndez J Carlos
Synthesis and structure-activity relationships of 1,5-diazaanthraquinones as antitumour compounds.
Bioorganic & medicinal chemistry letters 2004;14(15):3929-32.
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2004: Fuertes Miguel Angel; Pérez José Manuel; Alonso Carlos
Small amounts of urea and guanidine hydrochloride can be detected by a far-UV spectrophotometric method in dialysed protein solutions.
Journal of biochemical and biophysical methods 2004;59(3):209-16.
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2004: Fuertes Miguel Angel; Pérez José Manuel; Soto Manuel; Menéndez Margarita; Alonso Carlos
Thermodynamic stability of the C-terminal domain of the human inducible heat shock protein 70.
Biochimica et biophysica acta 2004;1699(1-2):45-56.
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2004: Pérez-Cabré M; Cervantes G; Moreno V; Prieto M J; Pérez J M; Font-Bardia M; Solans X
Pd(II) and Pt(II) complexes with aromatic diamines: study of their interaction with DNA.
Journal of inorganic biochemistry 2004;98(3):510-21.
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2003: Pérez José M; Kelland Lloyd R; Montero Eva I; Boxall Frances E; Fuertes Miguel A; Alonso Carlos; Navarro-Ranninger Carmen
Antitumor and cellular pharmacological properties of a novel platinum(IV) complex: trans-[PtCl(2)(OH)(2)(dimethylamine) (isopropylamine)].
Molecular pharmacology 2003;63(4):933-44.
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2003: Fuertes Miguel A; Alonso Carlos; Pérez José M
Biochemical modulation of Cisplatin mechanisms of action: enhancement of antitumor activity and circumvention of drug resistance.
Chemical reviews 2003;103(3):645-62.
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2002: Fuertes M A; Castilla J; Alonso C; Pérez J M
Novel concepts in the development of platinum antitumor drugs.
Current medicinal chemistry. Anti-cancer agents 2002;2(4):539-51.
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2002: Braña Miguel F; Casarrubios Luis; Domínguez Gema; Fernández Carlos; Pérez José M; Quiroga Adoración G; Navarro-Ranninger Carmen; de Pascual-Teresa Beatriz
Synthesis, cytotoxic activities and proposed mode of binding of a series of bis([(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl) alkylamines.
European journal of medicinal chemistry 2002;37(4):301-13.
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2002: Alvarez-Valdés Amparo; Pérez José Manuel; López-Solera Isabel; Lannegrand Raúl; Continente José Manuel; Amo-Ochoa Pilar; Camazón María José; Solans Xavier; Font-Bardía Mercè; Navarro-Ranninger Carmen
Preparation and characterization of platinum(II) and (IV) complexes of 1,3-diaminepropane and 1,4-diaminebutane: circumvention of cisplatin resistance and DNA interstrand cross-link formation in CH1cisR ovarian tumor cells.
Journal of medicinal chemistry 2002;45(9):1835-44.
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2002: Montero Eva I; Pérez José M; Schwartz Annie; Fuertes Miguel A; Malinge Jean M; Alonso Carlos; Leng Marc; Navarro-Ranninger Carmen
Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes.
Chembiochem : a European journal of chemical biology 2002;3(1):61-7.
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2001: Fuertes M A; Pérez J M; González V M; Alonso C
A kinetic model for the B-Z transition of poly[d(G-C)].poly[d(G-C)] and poly[d(G-m5C)].poly[d(G-m5C)].
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(7):675-82.
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2001: Jansen B A; Pérez J M; Pizarro A; Alonso C; Reedijk J; Navarro-Ranninger C
Sterically hindered cisplatin derivatives with multiple carboxylate auxiliary arms: synthesis and reactions with guanosine-5'-monophosphate and plasmid DNA.
Journal of inorganic biochemistry 2001;85(2-3):229-35.
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2001: Pérez J M; Cerrillo V; Matesanz A I; Millán J M; Navarro P; Alonso C; Souza P
DNA interstrand cross-linking efficiency and cytotoxic activity of novel cadmium(II)-thiocarbodiazone complexes.
Chembiochem : a European journal of chemical biology 2001;2(2):119-23.
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2001: Fuertes M A; Pérez J M; Soto M; López M C; Alonso C
Calcium-induced conformational changes in Leishmania infantum kinetoplastid membrane protein-11.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(1):107-17.
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2001: Pérez J M; Montero E I; Quiroga A G; Fuertes M A; Alonso C; Navarro-Ranninger C
Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl(2)(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells.
Metal-based drugs 2001;8(1):29-37.
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2000: Pérez J M; Fuertes M A; Alonso C; Navarro-Ranninger C
Current status of the development of trans-platinum antitumor drugs.
Critical reviews in oncology/hematology 2000;35(2):109-20.
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2000: González V M; Fuertes M A; Pérez-Alvarez M J; Cervantes G; Moreno V; Alonso C; Pérez J M
Induction of apoptosis by the bis-Pt(III) complex [Pt(2)(2-mercaptopyrimidine)(4)Cl(2)].
Biochemical pharmacology 2000;60(3):371-9.
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2000: Pérez J M; Montero E I; González A M; Solans X; Font-Bardia M; Fuertes M A; Alonso C; Navarro-Ranninger C
X-Ray structure of cytotoxic trans-[PtCl(2)(dimethylamine)(isopropylamine)]: interstrand cross-link efficiency, DNA sequence specificity, and inhibition of the B-Z transition.
Journal of medicinal chemistry 2000;43(12):2411-8.
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1999: Pérez J M; López-Solera I; Montero E I; Brana M F; Alonso C; Robinson S P; Navarro-Ranninger C
Combined effect of platination and intercalation upon DNA binding of novel cytotoxic Pt-bis(naphthalimide) complexes.
Journal of medicinal chemistry 1999;42(26):5482-6.
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1999: Fuertes M A; Pérez J M; González V M; Alonso C
Empirical validation of a two-state kinetic model for the B-Z transition of double-stranded poly[d(G-m5C)].
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(6):759-65.
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1999: Cervantes G; Marchal S; Prieto M J; Pérez J M; González V M; Alonso C; Moreno V
DNA interaction and antitumor activity of a Pt(III) derivative of 2-mercaptopyridine.
Journal of inorganic biochemistry 1999;77(3-4):197-203.
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1999: Flores A; Pérez J M
Cytotoxicity, apoptosis, and in vitro DNA damage induced by potassium chromate.
Toxicology and applied pharmacology 1999;161(1):75-81.
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1999: Pérez J M; Montero E I; González A M; Alvarez-Valdés A; Alonso C; Navarro-Ranninger C
Apoptosis induction and inhibition of H-ras overexpression by novel trans-[PtCl2(isopropylamine)(amine')] complexes.
Journal of inorganic biochemistry 1999;77(1-2):37-42.
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1999: Bloemink M J; Pérez J M; Heetebrij R J; Reedijk J
The new anticancer drug [(2R)-aminomethylpyrrolidine](1, 1-cyclobutanedicarboxylato)platinum(II) and its toxic S enantiomer do interact differently with nucleic acids.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(5):554-67.
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1999: Montero E I; Díaz S; González-Vadillo A M; Pérez J M; Alonso C; Navarro-Ranninger C
Preparation and characterization of novel trans-[PtCl(2)(amine)(isopropylamine)] compounds: cytotoxic activity and apoptosis induction in ras-transformed cells.
Journal of medicinal chemistry 1999;42(20):4264-8.
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1999: Matesanz A I; Pérez J M; Navarro P; Moreno J M; Colacio E; Souza P
Synthesis and characterization of novel palladium(II) complexes of bis(thiosemicarbazone). Structure, cytotoxic activity and DNA binding of Pd(II)-benzyl bis(thiosemicarbazonate).
Journal of inorganic biochemistry 1999;76(1):29-37.
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1999: Quiroga A G; Pérez J M; Montero E I; West D X; Alonso C; Navarro-Ranninger C
Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells.
Journal of inorganic biochemistry 1999;75(4):293-301.
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1999: Pérez J M; Matesanz A I; Martín-Ambite A; Navarro P; Alonso C; Souza P
Synthesis and characterization of complexes of p-isopropyl benzaldehyde and methyl 2-pyridyl ketone thiosemicarbazones with Zn(II) and Cd(II) metallic centers. Cytotoxic activity and induction of apoptosis in Pam-ras cells.
Journal of inorganic biochemistry 1999;75(4):255-61.
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1999: Onoa G B; Moreno V; Font-Bardia M; Solans X; Pérez J M; Alonso C
Structural and cytotoxic study of new Pt(II) and Pd(II) complexes with the bi-heterocyclic ligand mepirizole.
Journal of inorganic biochemistry 1999;75(3):205-12.
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1999: Pérez J M; Quiroga A G; Montero E I; Alonso C; Navarro-Ranninger C
A cycloplatinated compound of p-isopropylbenzaldehyde thiosemicarbazone and its chloro-bridged derivative induce apoptosis in cis-DDP resistant cells which overexpress the H-ras oncogene.
Journal of inorganic biochemistry 1999;73(4):235-43.
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1999: González V M; Fuertes M A; Jiménez-Ruíz A; Alonso C; Pérez J M
The formation of DNA interstrand cross-links by a novel bis-[Pt2Cl4(diminazene aceturate)2]Cl4.4H2O complex inhibits the B to Z transition.
Molecular pharmacology 1999;55(4):770-7.
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1998: Quiroga A G; Pérez J M; Montero E I; Masaguer J R; Alonso C; Navarro-Ranninger C
Palladated and platinated complexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes.
Journal of inorganic biochemistry 1998;70(2):117-23.
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1998: Quiroga A G; Pérez J M; López-Solera I; Masaguer J R; Luque A; Román P; Edwards A; Alonso C; Navarro-Ranninger C
Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA.
Journal of medicinal chemistry 1998;41(9):1399-408.
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1998: Quiroga A G; Pérez J M; López-Solera I; Montero E I; Masaguer J R; Alonso C; Navarro-Ranninger C
Binuclear chloro-bridged palladated and platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxicity against cisplatin resistant tumor cell lines.
Journal of inorganic biochemistry 1998;69(4):275-81.
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1997: González V M; Pérez J M; Alonso C
The berenil ligand directs the DNA binding of the cytotoxic drug Pt-berenil.
Journal of inorganic biochemistry 1997;68(4):283-7.
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1996: Amo-Ochoa P; González V M; Pérez J M; Masaguer J R; Alonso C; Navarro-Ranninger C
Cytotoxicity, DNA binding, and reactivity against nucleosides of platinum (II) and (IV) spermine compounds.
Journal of inorganic biochemistry 1996;64(4):287-99.
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1996: Pérez J M; González V M; Fuertes M A; Alonso C
Modification of the recognition of restriction sites of plasmid DNA by the antitumor drug Pt-pentamidine.
Biochemical pharmacology 1996;52(6):851-6.
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1996: González V M; Amo-Ochoa P; Pérez J M; Fuertes M A; Masaguer J R; Navarro-Ranninger C; Alonso C
Synthesis, characterization, and DNA modification induced by a novel Pt-berenil compound with cytotoxic activity.
Journal of inorganic biochemistry 1996;63(1):57-68.
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1996: González S; Tercero J M; Matilla A; Pérez J M; González V M; Alonso C; Niclós-Gutiérrez J
Cis-Dichloro(diaminosuccinate diethyl ester)palladium (II) as Pd(II)/Pt(II) model compound for DNA-binding and antitumor properties: solution equilibria of their aqua-, hydroxo-, and/or chloro-species.
Journal of inorganic biochemistry 1996;61(4):261-72.
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1994: López-Solera I; Pérez J M; Monge M A; Alvarez-Valdés A; Masaguer J R; Alonso C; Navarro-Ranninger C
Synthesis, crystal structure, and biological activity of a Pt-dipyridamole salt.
Journal of inorganic biochemistry 1994;56(4):233-42.
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1994: Matilla A; Tercero J M; Dung N H; Viossat B; Pérez J M; Alonso C; Martín-Ramos J D; Niclós-Gutiérrez J
cis-dichloro-palladium(II) complexes with diaminosuccinic acid and its diethyl ester: synthesis, molecular structure, and preliminary DNA-binding and antitumor studies.
Journal of inorganic biochemistry 1994;55(4):235-47.
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1994: Navarro-Ranninger C; Ochoa P A; Pérez J M; González V M; Masaguer J R; Alonso C
Platinum (II) and (IV) spermidine complexes. Synthesis, characterization, and biological studies.
Journal of inorganic biochemistry 1994;53(3):177-90.
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1993: Navarro-Ranninger C; López-Solera I; Pérez J M; Rodríguez J; García-Ruano J L; Raithby P R; Masaguer J R; Alonso C
Analysis of two cycloplatinated compounds derived from N-(4-methoxyphenyl)-alpha-benzoylbenzylidenamine. Comparison of the activity of these compounds with other isostructural cyclopalladated compounds.
Journal of medicinal chemistry 1993;36(24):3795-801.
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1993: Navarro-Ranninger C; Pérez J M; Zamora F; González V M; Masaguer J R; Alonso C
Palladium (II) compounds of putrescine and spermine. Synthesis, characterization, and DNA-binding and antitumor properties.
Journal of inorganic biochemistry 1993;52(1):37-49.
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1993: Pérez J M; Requena J M; Craciunescu D; Doadrio J C; Alonso C
Binding of Pt-pentamidine to nucleosomal DNA. Studies of the antiproliferative activity of the drug against human cancer cells.
Chemico-biological interactions 1993;89(1):61-72.
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1992: Navarro-Ranninger C; Ochoa P A; Pérez J M; Rodríguez J H; Masaguer J R; Alonso C
Platinum complexes of p- and m-aminobenzamidine. Synthesis, characterization, and cytotoxic activity.
Journal of inorganic biochemistry 1992;48(3):163-71.
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1992: Navarro-Ranninger C; Zamora F; Pérez J M; López-Solera I; Martínez-Carrera S; Masaguer J R; Alonso C
Palladium(II) salt and complexes of spermidine with a six-member chelate ring. Synthesis, characterization, and initial DNA-binding and antitumor studies.
Journal of inorganic biochemistry 1992;46(4):267-79.
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1991: Pérez J M; Navarro-Ranninger M C; Requena J M; Jimenéz-Ruiz A; Parrondo E; Craciunescu D; López M C; Alonso C
DNA binding properties and antileukemic (L1210) activity of a Pt-pentamidine complex.
Chemico-biological interactions 1991;77(3):341-55.
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