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John Perfect

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John R Perfect
Fungal diagnosis: how do we do it and can we do better?
Peter G Pappas; John R Perfect; Dimitrios P Kontoyiannis; Tom M Chiller
Real-time treatment guidelines: considerations during the Exserohilum rostratum outbreak in the United States.
Ying-Lien Chen; Virginia N Lehman; John R Perfect; Anna F Averette; Joseph Heitman
Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.

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2013: John R Perfect
Fungal diagnosis: how do we do it and can we do better?
Current medical research and opinion 2013;29 Suppl 4():3-11.
2013: Peter G Pappas; John R Perfect; Dimitrios P Kontoyiannis; Tom M Chiller
Real-time treatment guidelines: considerations during the Exserohilum rostratum outbreak in the United States.
Antimicrobial agents and chemotherapy 2013;57(4):1573-6.
2013: Ying-Lien Chen; Virginia N Lehman; John R Perfect; Anna F Averette; Joseph Heitman
Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.
PloS one 2013;8(3):e57672.
2013: Sanne P. Smeekens; Jos W M van der Meer; Cleo van Diemen; Suzanne van Sommeren; Eugène T P Verwiel; Cisca Wijmenga; Peer Arts; Shih-Chin Cheng; Karin Fransen; Mark S Gresnigt; Alexander Hoischen; Melissa D Johnson; Leo A B Joosten; Bart Jan Kullberg; Vinod Kumar; Mihai G Netea; Aylwin Ng; Marije Oosting; John R Perfect; Theo S Plantinga; William K Scott; Ramnik J Xavier
Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.
Nature communications 2013;4():1342.
2012: Wiley A Schell; P Brian Smith; Barbara D Alexander; Daniel K Benjamin; J L Benton; D J Boles; Allen E Eckhardt; M D Johnson; Vamsee K Pamula; John R Perfect; M G Pollack; M Poore; J L Rouse; Thomas G Mitchell
Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2012;31(9):2237-45.
2012: Theo S Plantinga; William Scott; P Brian Smith; Esther van de Vosse; Jos W M van der Meer; Jaap T van Dissel; Digna R Velez Edwards; THOMAS WALSH; John C Yang; Barbara D Alexander; Melissa D Johnson; Leo A B Joosten; Dennis Kremer; Bart Jan Kullberg; Gregory M Laird; Marije Oosting; John R Perfect; Mihai G Netea
Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.
The Journal of infectious diseases 2012;205(6):934-43.
2012: Brad Spellberg; Peter V Chin-Hong; David Fredricks; Ashraf S Ibrahim; Dimitrios P Kontoyiannis; Michele Morris; John R Perfect; Eric P Brass
The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial.
The Journal of antimicrobial chemotherapy 2012;67(3):715-22.
2012: D C Rosentul; William Scott; N M D van de Geer; John R Perfect; T S Plantinga; B D Alexander; M D Johnson; Bart Jan Kullberg; Mihai G Netea
The impact of caspase-12 on susceptibility to candidemia.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2012;31(3):277-80.
2012: Melissa D Johnson; Leo A B Joosten; Dennis Kremer; Bart Jan Kullberg; Gregory M Laird; Barbara D Alexander; Marije Oosting; John R Perfect; Theo S Plantinga; William Scott; P Brian Smith; Esther van de Vosse; Jos W M van der Meer; Jaap T van Dissel; Digna R Velez Edwards; THOMAS WALSH; John C Yang; Mihai G Netea
Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;54(4):502-10.
2012: Rebecca S Shapiro; Aimee K Zaas; Marisol Betancourt-Quiroz; John R Perfect; Leah E Cowen
The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.
PloS one 2012;7(9):e44734.
2012: Kimberly E Hanson; Erika D Lease; John R Perfect; Christopher D Pfeiffer; Aimee K Zaas; Alfred H Balch; Barbara D Alexander
β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study.
PloS one 2012;7(8):e42282.
2012: John R Perfect
The triple threat of cryptococcosis: it's the body site, the strain, and/or the host.
mBio 2012;3(4):.
2011: Russell J McCulloh; John R Perfect; Raina Phillips; Edmond J Byrnes; Joseph Heitman; Elizabeth Dufort
Cryptococcus gattii genotype VGI infection in New England.
The Pediatric infectious disease journal 2011;30(12):1111-4.
2011: Camile P Semighini; John R Perfect; Anna F Averette; Joseph Heitman
Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.
PLoS pathogens 2011;7(11):e1002364.
2011: John R Perfect; Michael A Pfaller; Luis Ostrosky-Zeichner; Dimitrios P Kontoyiannis
Invasive mycoses: evolving challenges and opportunities in antifungal therapy (multimedia activity).
The American journal of medicine 2011;124(10):S2-3.
2011: Diana C Rosentul; William Scott; P Brian Smith; Jos W M van der Meer; Digna R Velez Edwards; John C Yang; Leo A B Joosten; Bart Jan Kullberg; Gregory M Laird; Mihai G Netea; Marije Oosting; John R Perfect; Theo S Plantinga; Barbara D Alexander; Melissa D Johnson
Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.
The Journal of infectious diseases 2011;204(7):1138-45.
2011: Edmond J Byrnes; Karen H Bartlett; John R Perfect; Joseph Heitman
Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals.
Microbes and infection / Institut Pasteur 2011;13(11):895-907.
2011: Rachelle A Rebong; Ricardo M Santaella; William J Steinbach; Brian E Goldhagen; Christopher P Majka; John R Perfect; Natalie A Afshari
Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.
Investigative ophthalmology & visual science 2011;52(10):7309-15.
2011: Christopher D Pfeiffer; L Barth Reller; Gregory P Samsa; Wiley A Schell; John R Perfect; Barbara D Alexander
Quantitation of Candida CFU in initial positive blood cultures.
Journal of clinical microbiology 2011;49(8):2879-83.
2011: Joseph Menzin; Juliana L Meyers; Mark Friedman; Jonathan R Korn; John R Perfect; Amelia A Langston; Robert P Danna; George Papadopoulos
The economic costs to United States hospitals of invasive fungal infections in transplant patients.
American journal of infection control 2011;39(4):e15-20.
2011: Hsiang-Kuang Tseng; John R Perfect
Strategies to manage antifungal drug resistance.
Expert opinion on pharmacotherapy 2011;12(2):241-56.
2011: Luis Ostrosky-Zeichner; Bart Jan Kullberg; Eric J Bow; Susan Hadley; Cristóbal León; Marcio Nucci; Thomas Patterson; John R Perfect
Early treatment of candidemia in adults: a review.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2011;49(2):113-20.
2011: Guanggan Hu; Won Hee Jung; Rajeev Aurora; Tihana Bicanic; Jaehyuk Choi; Anastasia P Litvintseva; Iris Liu; Thomas G Mitchell; John R Perfect; Joyce Wang; James W Kronstad
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.
BMC genomics 2011;12():526.
2011: Michael S Price; John R Perfect
Host defenses against cryptococcosis.
Immunological investigations 2011;40(7-8):786-808.
2011: Michael S Price; Dena L Toffaletti; Haily Vora; Jennifer L Price; Marisol Betancourt-Quiroz; Guanggan Hu; James W Kronstad; John R Perfect
Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
mBio 2011;2(3):e00103-11.
2011: Popchai Ngamskulrungroj; Jennifer Price; Tania Sorrell; John R Perfect; Wieland Meyer
Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver island outbreak strains.
PloS one 2011;6(1):e16076.
2011: Andrew H Limper; Kenneth S Knox; George A Sarosi; Neil M Ampel; JOHN BENNETT; Antonino Catanzaro; Scott F Davies; William E Dismukes; Chadi A Hage; Kieren Marr; Christopher H Mody; John R Perfect; David A Stevens
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
American journal of respiratory and critical care medicine 2011;183(1):96-128.
2010: Barbara D Alexander; P Brian Smith; R Duane Davis; John R Perfect; L Barth Reller
The (1,3){beta}-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation.
Journal of clinical microbiology 2010;48(11):4083-8.
2010: Anthony Lee; Dena L Toffaletti; Jennifer Tenor; Erik J Soderblom; J Will Thompson; M Arthur Moseley; Michael Price; John R Perfect
Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.
Infection and immunity 2010;78(10):4213-25.
2010: Christopher D Pfeiffer; Guillermo Garcia-Effron; Aimee K Zaas; John R Perfect; David S Perlin; Barbara D Alexander
Breakthrough invasive candidiasis in patients on micafungin.
Journal of clinical microbiology 2010;48(7):2373-80.
2010: Elizabeth Wulff-Burchfield; Wiley A Schell; Allen E Eckhardt; Michael G Pollack; Zhishan Hua; Jeremy L Rouse; Vamsee K Pamula; Vijay Srinivasan; Jonathan L Benton; Barbara D Alexander; David A Wilfret; Monica Kraft; Charles B Cairns; John R Perfect; Thomas G Mitchell
Microfluidic platform versus conventional real-time polymerase chain reaction for the detection of Mycoplasma pneumoniae in respiratory specimens.
Diagnostic microbiology and infectious disease 2010;67(1):22-9.
2010: Jarrod R Fortwendel; Praveen Rao Juvvadi; B Zachary Perfect; Luise E Rogg; John R Perfect; William J Steinbach
Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.
Antimicrobial agents and chemotherapy 2010;54(4):1555-63.
2010: Aimee K Zaas; Hamza Aziz; Joseph Lucas; John R Perfect; Geoffrey S Ginsburg
Blood gene expression signatures predict invasive candidiasis.
Science translational medicine 2010;2(21):21ra17.
2010: John R Perfect; William E Dismukes; Francoise Dromer; David Goldman; John Graybill; Richard J Hamill; Thomas S Harrison; Robert A Larsen; Olivier Lortholary; Minh-Hong Nguyen; Peter G Pappas; William G Powderly; Nina Singh; Jack D Sobel; Tania C Sorrell
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;50(3):291-322.
2010: Shantelle L LaFayette; Cathy Collins; Aimee K Zaas; Wiley A Schell; Marisol Betancourt-Quiroz; Leslie Gunatilaka; John R Perfect; Leah E Cowen
PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
PLoS pathogens 2010;6(8):e1001069.
2009: Dustin T Wilson; Richard H Drew; John R Perfect
Antifungal therapy for invasive fungal diseases in allogeneic stem cell transplant recipients: an update.
Mycopathologia 2009;168(6):313-27.
2009: Bart Ferwerda; Gerben Ferwerda; Theo S Plantinga; Janet A Willment; Annemiek B van Spriel; Hanka Venselaar; Clara C Elbers; Melissa D Johnson; Alessandra Cambi; Cristal Huysamen; Liesbeth Jacobs; Trees Jansen; Karlijn Verheijen; Laury Masthoff; Servaas A Morré; Gert Vriend; David L Williams; John R Perfect; Leo A B Joosten; Cisca Wijmenga; Jos W M van der Meer; Gosse J Adema; Bart Jan Kullberg; Gordon D Brown; Mihai G Netea
Human dectin-1 deficiency and mucocutaneous fungal infections.
The New England journal of medicine 2009;361(18):1760-7.
2009: Joseph Menzin; Juliana L Meyers; Mark Friedman; John R Perfect; Amelia A Langston; Robert P Danna; George Papadopoulos
Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2009;66(19):1711-7.
2009: Popchai Ngamskulrungroj; Uwe Himmelreich; Julia Breger; Christabel Wilson; Methee Chayakulkeeree; Mark B Krockenberger; Richard Malik; Heide-Marie Daniel; Dena L Toffaletti; Julianne T Djordjevic; Eleftherios Mylonakis; Wieland Meyer; John R Perfect
The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.
Infection and immunity 2009;77(10):4584-96.
2009: Sheena D Singh; Nicole Robbins; Aimee K Zaas; Wiley A Schell; John R Perfect; Leah E Cowen
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.
PLoS pathogens 2009;5(7):e1000532.
2009: Scarlett Geunes-Boyer; Timothy Oliver; Guilhem Janbon; Jennifer lodge; Joseph Heitman; John R Perfect; Jo Rae Wright
Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival.
Infection and immunity 2009;77(7):2783-94.
2009: Elizabeth S Dodds Ashley; Jay B Varkey; Gopal Krishna; Donna Vickery; Lei Ma; Xin Yu; Darshana Malavade; Megan Goodwin; John R Perfect; Eddie Power
Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers.
Antimicrobial agents and chemotherapy 2009;53(7):2960-4.
2009: Susanna Naggie; John R Perfect
Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis.
Clinics in chest medicine 2009;30(2):337-53, vii-viii.
2009: Rebecca S Shapiro; priya uppuluri; Aimee K Zaas; Cathy Collins; Heather Senn; John R Perfect; Joseph Heitman; Leah E Cowen
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.
Current biology : CB 2009;19(8):621-9.
2009: Nadthanan Pinchai; B Zachary Perfect; Praveen Rao Juvvadi; Jarrod R Fortwendel; Robert A Cramer; Yohannes G Asfaw; Joseph Heitman; John R Perfect; William J Steinbach
Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.
Eukaryotic cell 2009;8(4):511-9.
2009: Winter J Smith; Richard H Drew; John R Perfect
Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.
Expert review of anti-infective therapy 2009;7(2):165-81.
2009: Matthew C Caldwell; John R Perfect; Alan N Carlson; Alan D Proia
Candida glabrata endophthalmitis following penetrating keratoplasty.
Journal of cataract and refractive surgery 2009;35(3):598-602.
2009: Leah E Cowen; Sheena D Singh; Julia R Köhler; Cathy Collins; Aimee K Zaas; Wiley A Schell; Hamza Aziz; Eleftherios Mylonakis; John R Perfect; Luke Whitesell; Susan Lindquist
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2818-23.
2009: Jarrod R Fortwendel; Praveen Rao Juvvadi; Nadthanan Pinchai; B Zachary Perfect; J Andrew Alspaugh; John R Perfect; William J Steinbach
Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2009;53(2):476-82.
2009: Edmond J Byrnes; Wenjun Li; Yonathan Lewit; John R Perfect; Dee A Carter; Gary M Cox; Joseph Heitman
First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen.
PloS one 2009;4(6):e5851.
2008: Ray Hachem; A A Langston; John Graybill; John R Perfect; Lisa Pedicone; H Patino; Issam I Raad
Posaconazole as salvage treatment of invasive fungal infections in patients with underlying renal impairment.
The Journal of antimicrobial chemotherapy 2008;62(6):1386-91.
2008: Nina Singh; Francoise Dromer; John R Perfect; Olivier Lortholary
Cryptococcosis in solid organ transplant recipients: current state of the science.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(10):1321-7.
2008: John W Baddley; John R Perfect; Robert A Oster; Robert A Larsen; George A Pankey; H Henderson; David W Haas; Carol A Kauffman; R Patel; Aimee K Zaas; Peter G Pappas
Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2008;27(10):937-43.
2008: Barbara D Alexander; John R Perfect; Jennifer S Daly; Angela Restrepo; Angela M Tobón; Hernando Patino; Catherine J Hardalo; John Graybill
Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant.
Transplantation 2008;86(6):791-6.
2008: Guanggan Hu; Po-Yan Cheng; Anita P Sham; John R Perfect; James W Kronstad
Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection.
Molecular microbiology 2008;69(6):1456-75.
2008: Brahm H Segal; Raoul Herbrecht; David A Stevens; Luis Ostrosky-Zeichner; Jack D Sobel; Claudio Viscoli; THOMAS WALSH; Johan Maertens; Thomas Patterson; John R Perfect; Bertrand Dupont; John R Wingard; Thierry Calandra; Carol A Kauffman; John Graybill; Lindsey R Baden; Peter G Pappas; JOHN BENNETT; Dimitrios P Kontoyiannis; Catherine Cordonnier; Maria Anna Viviani; Jacques Bille; Nikolaos G Almyroudis; L Joseph Wheat; Wolfgang Graninger; Eric J Bow; Steven M Holland; Bart Jan Kullberg; William E Dismukes; Ben E De Pauw
Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(5):674-83.
2008: Robert A Cramer; B Zachary Perfect; Nadthanan Pinchai; Steven Park; David Perlin; Yohannes G Asfaw; Joseph Heitman; John R Perfect; William J Steinbach
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
Eukaryotic cell 2008;7(7):1085-97.
2008: Aimee K Zaas; Guochun Liao; Jason W Chien; Clarice Weinberg; David Shore; Steven S Giles; Kieren Marr; Jonathan Usuka; Lauranell H Burch; Lalith Perera; John R Perfect; Gary Peltz; David A Schwartz
Plasminogen alleles influence susceptibility to invasive aspergillosis.
PLoS genetics 2008;4(6):e1000101.
2008: Marcio Nucci; John R Perfect
When primary antifungal therapy fails.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1426-33.
2008: John R Perfect
Aerosolized antifungal prophylaxis: the winds of change?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1409-11.
2008: Jay B Varkey; John R Perfect
Rare and emerging fungal pulmonary infections.
Seminars in respiratory and critical care medicine 2008;29(2):121-31.
2008: Zeina A Kanafani; John R Perfect
Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(1):120-8.
2007: Nina Singh; John R Perfect
Immune reconstitution syndrome and exacerbation of infections after pregnancy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(9):1192-9.
2007: Michael S Waugh; John R Perfect; Rajesh C Dash
Schistosoma haematobium in urine: morphology with ThinPrep method.
Diagnostic cytopathology 2007;35(10):649-50.
2007: Methee Chayakulkeeree; Thomas H Rude; Dena L Toffaletti; John R Perfect
Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target.
Antimicrobial agents and chemotherapy 2007;51(10):3537-45.
2007: Chiatogu Onyewu; Emily Eads; Wiley A Schell; John R Perfect; Yehuda Ullmann; Gil Kaufman; Benjamin A Horwitz; Israela Berdicevsky; Joseph Heitman
Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
Antimicrobial agents and chemotherapy 2007;51(10):3743-6.
2007: William J Steinbach; Robert A Cramer; B Zachary Perfect; Christina Henn; Kirsten Nielsen; Joseph Heitman; John R Perfect
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2007;51(8):2979-81.
2007: William J Steinbach; Rachel M Addison; Lisa McLaughlin; Quincy D Gerrald; Paul L Martin; Timothy A Driscoll; Christopher Bentsen; John R Perfect; Barbara D Alexander
Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients.
The Pediatric infectious disease journal 2007;26(7):558-64.
2007: Nina Singh; John R Perfect
Immune reconstitution syndrome associated with opportunistic mycoses.
The Lancet infectious diseases 2007;7(6):395-401.
2007: William J Steinbach; Jennifer L Reedy; Robert A Cramer; John R Perfect; Joseph Heitman
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
Nature reviews. Microbiology 2007;5(6):418-30.
2007: Floyd L Wormley; John R Perfect; Chad Steele; Gary M Cox
Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.
Infection and immunity 2007;75(3):1453-62.
2007: Barbara D Alexander; Terry C Byrne; Kelly L Smith; Kimberly E Hanson; Kevin J Anstrom; John R Perfect; L Barth Reller
Comparative evaluation of Etest and sensititre yeastone panels against the Clinical and Laboratory Standards Institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents.
Journal of clinical microbiology 2007;45(3):698-706.
2007: Elizabeth S Dodds Ashley; Aimee K Zaas; A F Fang; Bharat D Damle; John R Perfect
Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets.
Antimicrobial agents and chemotherapy 2007;51(3):877-80.
2007: John R Perfect
Management of cryptococcosis: how are we doing?
PLoS medicine 2007;4(2):e47.
2007: Brahm H Segal; Nikolaos G Almyroudis; Minoo Battiwalla; Raoul Herbrecht; John R Perfect; THOMAS WALSH; John R Wingard
Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;44(3):402-9.
2007: Oliver A Cornely; Johan Maertens; Drew J Winston; John R Perfect; Andrew J Ullmann; THOMAS WALSH; David Helfgott; Jerzy Holowiecki; Dick Stockelberg; Yeow Tee Goh; Mario Petrini; Catherine J Hardalo; Ramachandran Suresh; David Angulo-Gonzalez
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.
The New England journal of medicine 2007;356(4):348-59.
2007: Steven S Giles; Aimee K Zaas; Mike F Reidy; John R Perfect; Jo Rae Wright
Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.
PloS one 2007;2(12):e1370.
2007: THOMAS WALSH; Issam Raad; Thomas Patterson; Pranatharthi H Chandrasekar; Gerald R Donowitz; Richard Graybill; Reginald E Greene; Ray Hachem; Susan Hadley; Raoul Herbrecht; Amelia Langston; Arnold Louie; Patricia Ribaud; Brahm H Segal; David A Stevens; Jo-Anne H van Burik; Charles S White; Gavin Corcoran; Jagadish Gogate; Gopal Krishna; Lisa Pedicone; Catherine J Hardalo; John R Perfect
Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;44(1):2-12.
2007: Alexander Idnurm; Steven S Giles; John R Perfect; Joseph Heitman
Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans.
Eukaryotic cell 2007;6(1):60-72.
2006: Robert A Cramer; Jason E Stajich; Yvonne Yamanaka; Fred S Dietrich; William J Steinbach; John R Perfect
Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.
Gene 2006;383():24-32.
2006: Aimee K Zaas; Elizabeth S Dodds Ashley; Barbara D Alexander; Melissa D Johnson; John R Perfect
Caspofungin for invasive candidiasis at a tertiary care medical center.
The American journal of medicine 2006;119(11):993.e1-6.
2006: Elizabeth Wills Petzold; Uwe Himmelreich; Eleftherios Mylonakis; Thomas H Rude; Dena L Toffaletti; Gary M Cox; Jackie L Miller; John R Perfect
Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.
Infection and immunity 2006;74(10):5877-87.
2006: Methee Chayakulkeeree; John R Perfect
Cryptococcosis.
Infectious disease clinics of North America 2006;20(3):507-44, v-vi.
2006: Steven S Giles; Jason E Stajich; Connie Nichols; Quincy D Gerrald; J Andrew Alspaugh; Fred S Dietrich; John R Perfect
The Cryptococcus neoformans catalase gene family and its role in antioxidant defense.
Eukaryotic cell 2006;5(9):1447-59.
2006: William J Steinbach; Robert A Cramer; B Zachary Perfect; Yohannes G Asfaw; Theodor C Sauer; Laura K Najvar; William R Kirkpatrick; Thomas Patterson; Daniel K Benjamin; Joseph Heitman; John R Perfect
Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
Eukaryotic cell 2006;5(7):1091-103.
2006: Issam I Raad; John Graybill; Ana Beatriz Bustamante; Oliver A Cornely; Veronica Gaona-Flores; Claude Afif; Donald R Graham; Richard N Greenberg; Susan Hadley; Amelia Langston; Ricardo Negroni; John R Perfect; Punnee Pitisuttithum; Angela Restrepo; Gary J Schiller; Lisa Pedicone; Andrew J Ullmann
Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(12):1726-34.
2006: Robert A Cramer; Michael P Gamcsik; Rhea M Brooking; Laura K Najvar; William R Kirkpatrick; Thomas Patterson; Carl J Balibar; John Graybill; John R Perfect; Soman N Abraham; William J Steinbach
Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
Eukaryotic cell 2006;5(6):972-80.
2006: John R Perfect
Cryptococcus neoformans: the yeast that likes it hot.
FEMS yeast research 2006;6(4):463-8.
2006: Michelle S Turner; Richard H Drew; John R Perfect
Emerging echinocandins for treatment of invasive fungal infections.
Expert opinion on emerging drugs 2006;11(2):231-50.
2006: Methee Chayakulkeeree; Mahmoud A Ghannoum; John R Perfect
Zygomycosis: the re-emerging fungal infection.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2006;25(4):215-29.
2006: Barbara D Alexander; Elizabeth S Dodds Ashley; R M Addison; J Andrew Alspaugh; N J Chao; John R Perfect
Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation.
Transplant infectious disease : an official journal of the Transplantation Society 2006;8(1):13-20.
2005: Yong-Sun Bahn; Gary M Cox; John R Perfect; Joseph Heitman
Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence.
Current biology : CB 2005;15(22):2013-20.
2005: Mariceli Araujo Ribeiro; Claudete Rodrigues Paula; R John; John R Perfect; Gary M Cox
Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(7):647-50.
2005: James A Fraser; Steven S Giles; Emily C Wenink; Scarlett G Geunes-Boyer; Jo Rae Wright; Stephanie Diezmann; Andria Allen; Jason E Stajich; Fred S Dietrich; John R Perfect; Joseph Heitman
Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak.
Nature 2005;437(7063):1360-4.
2005: William J Steinbach; John R Perfect; Christopher H Cabell; Vance G Fowler; G Ralph Corey; Jennifer S Li; Aimee K Zaas; Daniel K Benjamin
A meta-analysis of medical versus surgical therapy for Candida endocarditis.
The Journal of infection 2005;51(3):230-47.
2005: Barbara D Alexander; Wiley A Schell; Jackie L Miller; Gwynn D Long; John R Perfect
Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole.
Transplantation 2005;80(6):868-71.
2005: John R Perfect
Cryptococcus neoformans: a sugar-coated killer with designer genes.
FEMS immunology and medical microbiology 2005;45(3):395-404.
2005: Floyd L Wormley; Garrett Heinrich; Jackie L Miller; John R Perfect; Gary M Cox
Identification and characterization of an SKN7 homologue in Cryptococcus neoformans.
Infection and immunity 2005;73(8):5022-30.
2005: Kirsten Nielsen; Gary M Cox; Anastasia P Litvintseva; Eleftherios Mylonakis; Stephanie D Malliaris; Daniel K Benjamin; Steven S Giles; Thomas G Mitchell; Arturo Casadevall; John R Perfect; Joseph Heitman
Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection.
Infection and immunity 2005;73(8):4922-33.
2005: Christopher Y Chang; Wiley A Schell; John R Perfect; Gregory F Hulka
Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis.
The Laryngoscope 2005;115(6):1065-9.
2005: Richard H Drew; Rebekah R Arthur; John R Perfect
Is it time to abandon the use of amphotericin B bladder irrigation?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40(10):1465-70.
2005: John R Perfect
Nuances of new anti-Aspergillus antifungals.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43 Suppl 1():S271-6.
2005: Larry M Baddour; John R Perfect; Luis Ostrosky-Zeichner
Successful use of amphotericin B lipid complex in the treatment of cryptococcosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40 Suppl 6():S409-13.
2005: John R Perfect
Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40 Suppl 6():S401-8.
2005: Winter J Gibbs; Richard H Drew; John R Perfect
Liposomal amphotericin B: clinical experience and perspectives.
Expert review of anti-infective therapy 2005;3(2):167-81.
2005: Robert A Larsen; Peter G Pappas; John R Perfect; Judith A Aberg; Arturo Casadevall; Gretchen A Cloud; Robert James; Scott Filler; William E Dismukes
Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis.
Antimicrobial agents and chemotherapy 2005;49(3):952-8.
2005: Floyd L Wormley; Gary M Cox; John R Perfect
Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.
Microbial pathogenesis 2005;38(2-3):113-23.
2005: Floyd L Wormley; John R Perfect
Immunology of infection caused by Cryptococcus neoformans.
Methods in molecular medicine 2005;118():193-8.
2005: Priya Venkatesan; John R Perfect; Sarah A Myers
Evaluation and management of fungal infections in immunocompromised patients.
Dermatologic therapy 2005;18(1):44-57.
2005: Steven S Giles; Ines Batinic-Haberle; John R Perfect; Gary M Cox
Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.
Eukaryotic cell 2005;4(1):46-54.
2005: Steven S Giles; John R Perfect; Gary M Cox
Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.
Fungal genetics and biology : FG & B 2005;42(1):20-9.
2004: John R Perfect
Antifungal resistance: the clinical front.
Oncology (Williston Park, N.Y.) 2004;18(14 Suppl 13):15-22.
2004: William J Steinbach; Nina Singh; Jackie L Miller; Daniel K Benjamin; Wiley A Schell; Joseph Heitman; John R Perfect
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
Antimicrobial agents and chemotherapy 2004;48(12):4922-5.
2004: Chiatogu Onyewu; Floyd L Wormley; John R Perfect; Joseph Heitman
The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
Infection and immunity 2004;72(12):7330-3.
2004: John R Perfect
Use of newer antifungal therapies in clinical practice: what do the data tell us?
Oncology (Williston Park, N.Y.) 2004;18(13 Suppl 7):15-23.
2004: John R Perfect
Management of invasive mycoses in hematology patients: current approaches.
Oncology (Williston Park, N.Y.) 2004;18(13 Suppl 7):5-14.
2004: John R Perfect; Elizabeth S Dodds Ashley; Richard H Drew
Design of aerosolized amphotericin b formulations for prophylaxis trials among lung transplant recipients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39 Suppl 4():S207-10.
2004: William J Steinbach; Daniel K Benjamin; Scott A Trasi; Jackie L Miller; Wiley A Schell; Aimee K Zaas; W Michael Foster; John R Perfect
Value of an inhalational model of invasive aspergillosis.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2004;42(5):417-25.
2004: María-Jesús Jiménez-Expósito; G Torres; A Baraldés; Natividad Benito; F Marco; J C Paré; A Moreno; Xavier Claramonte; Carlos A Mestres; Manel Almela; C García de la María; N Pérez; W A Schell; G Ralph Corey; John R Perfect; M Teresa Jiménez de Anta; José M Gatell; José M Miró
Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(7):e70-3.
2004: Peter R Kraus; Marie-Josée Boily; Steven S Giles; Jason E Stajich; Andria Allen; Gary M Cox; Fred S Dietrich; John R Perfect; Joseph Heitman
Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.
Eukaryotic cell 2004;3(5):1249-60.
2004: Dena L Toffaletti; Kirsten Nielsen; Fred S Dietrich; Joseph Heitman; John R Perfect
Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence.
Current genetics 2004;46(4):193-204.
2004: William J Steinbach; John R Perfect; Wiley A Schell; THOMAS WALSH; Daniel K Benjamin
In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection.
Antimicrobial agents and chemotherapy 2004;48(9):3217-25.
2004: Takuya Miwa; Yukinobu Takagi; Makiko Shinozaki; Cheol-Won Yun; Wiley A Schell; John R Perfect; Hidehiko Kumagai; Hisanori Tamaki
Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.
Eukaryotic cell 2004;3(4):919-31.
2004: Rebekah R Arthur; Richard H Drew; John R Perfect
Novel modes of antifungal drug administration.
Expert opinion on investigational drugs 2004;13(8):903-32.
2004: William J Steinbach; Daniel K Benjamin; Dimitrios P Kontoyiannis; John R Perfect; Irja Lutsar; Kieren Marr; Michail S Lionakis; Harrys A Torres; Hasan Jafri; THOMAS WALSH
Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(2):192-8.
2004: Michal Olszewski; Mairi Catherine Noverr; Gwo-Hsiao Chen; Galen Toews; Gary M Cox; John R Perfect; Gary B Huffnagle
Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.
The American journal of pathology 2004;164(5):1761-71.
2004: William J Steinbach; Wiley A Schell; Jill R Blankenship; Chiatogu Onyewu; Joseph Heitman; John R Perfect
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2004;48(5):1664-9.
2004: Jason C Gallagher; Conan MacDougall; Elizabeth S Dodds Ashley; John R Perfect
Recent advances in antifungal pharmacotherapy for invasive fungal infections.
Expert review of anti-infective therapy 2004;2(2):253-68.
2004: Barbara Alexander Lodge; Elizabeth Dodds Ashley; Mark P Steele; John R Perfect
Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole.
Journal of clinical microbiology 2004;42(3):1376-8.
2004: Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Combination antifungal therapy.
Antimicrobial agents and chemotherapy 2004;48(3):693-715.
2004: Jackie L Miller; Wiley A Schell; EA Wills; Dena L Toffaletti; M Boyce; Daniel K Benjamin; J Bartroli; John R Perfect
In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2004;48(2):384-7.
2004: Richard H Drew; Elizabeth S Dodds Ashley; Daniel K Benjamin; R Duane Davis; Scott M Palmer; John R Perfect
Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients.
Transplantation 2004;77(2):232-7.
2004: Daniel K Benjamin; Jose M Miro; Bruno Hoen; William J Steinbach; Vance G Fowler; Lars Olaison; Gilbert Habib; Elias Abrutyn; John R Perfect; Amy Zass; G Ralph Corey; Susannah Eykyn; Franck Thuny; María-Jesús Jiménez-Expósito; Christopher H Cabell
Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD).
Scandinavian journal of infectious diseases 2004;36(6-7):453-5.
2004: William J Steinbach; Wiley A Schell; J L Miller; John R Perfect; Paul L Martin
Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients.
The Journal of infection 2004;48(1):112-6.
2003: William J Steinbach; Thomas G Mitchell; Wiley A Schell; Ana Espinel-Ingroff; Richard Coico; THOMAS WALSH; John R Perfect
Status of medical mycology education.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2003;41(6):457-67.
2003: William J Steinbach; John R Perfect
Scedosporium species infections and treatments.
Journal of chemotherapy (Florence, Italy) 2003;15 Suppl 2():16-27.
2003: Aimee K Zaas; Molly Boyce; Wiley Schell; Barbara Alexander Lodge; Jackie L Miller; John R Perfect
Risk of fungemia due to Rhodotorula and antifungal susceptibility testing of Rhodotorula isolates.
Journal of clinical microbiology 2003;41(11):5233-5.
2003: Chiara Luberto; Beatriz Martinez-Mariño; Daniel Taraskiewicz; Benjamin Bolaños; Pasquale Chitano; Dena L Toffaletti; Gary M Cox; John R Perfect; Yusuf A Hannun; Edward Balish; Maurizio Del Poeta
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.
The Journal of clinical investigation 2003;112(7):1080-94.
2003: Shamima Akhter; Henry C McDade; Jenifer M Gorlach; Garrett Heinrich; Gary M Cox; John R Perfect
Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans.
Infection and immunity 2003;71(10):5794-802.
2003: Kirsten Nielsen; Gary M Cox; Ping Wang; Dena L Toffaletti; John R Perfect; Joseph Heitman
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.
Infection and immunity 2003;71(9):4831-41.
2003: Jane V Trinh; William J Steinbach; Wiley A Schell; Joanne Kurtzberg; Steven S Giles; John R Perfect
Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2003;41(4):339-45.
2003: William J Steinbach; Wiley A Schell; Jackie L Miller; John R Perfect
Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.
Journal of clinical microbiology 2003;41(8):3981-5.
2003: Arnaldo Lopes Colombo; John R Perfect; Mark J DiNubile; Ken Bartizal; Mary Motyl; P Hicks; Robert J Lupinacci; Carole A Sable; Nicholas A Kartsonis
Global distribution and outcomes for Candida species causing invasive candidiasis: results from an international randomized double-blind study of caspofungin versus amphotericin B for the treatment of invasive candidiasis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2003;22(8):470-4.
2003: Magnus Gottfredsson; James J Vredenburgh; Jianping Xu; Wiley A Schell; John R Perfect
Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation.
Cancer 2003;98(1):24-30.
2003: Robert C Davidson; Connie B Nichols; Gary M Cox; John R Perfect; Joseph Heitman
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
Molecular microbiology 2003;49(2):469-85.
2003: Jill R Blankenship; Floyd L Wormley; Molly K Boyce; Wiley A Schell; Scott Filler; John R Perfect; Joseph Heitman
Calcineurin is essential for Candida albicans survival in serum and virulence.
Eukaryotic cell 2003;2(3):422-30.
2003: Melissa D Johnson; John R Perfect
Caspofungin: first approved agent in a new class of antifungals.
Expert opinion on pharmacotherapy 2003;4(5):807-23.
2003: John R Perfect; Kieren Marr; THOMAS WALSH; Richard N Greenberg; Bertrand Dupont; Juliàn de la Torre-Cisneros; Gudrun Just-Nübling; Haran T Schlamm; Irja Lutsar; Ana Espinel-Ingroff; Elizabeth Johnson
Voriconazole treatment for less-common, emerging, or refractory fungal infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003;36(9):1122-31.
2003: Dena L Toffaletti; Maurizio Del Poeta; Thomas H Rude; Fred S Dietrich; John R Perfect
Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.
Microbiology (Reading, England) 2003;149(Pt 4):1041-9.
2003: William J Steinbach; John R Perfect
Newer antifungal therapy for emerging fungal pathogens.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2003;7(1):5-20.
2003: Mairi Catherine Noverr; Gary M Cox; John R Perfect; Gary B Huffnagle
Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production.
Infection and immunity 2003;71(3):1538-47.
2003: Jill R Blankenship; William J Steinbach; John R Perfect; Joseph Heitman
Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.
Current opinion in investigational drugs (London, England : 2000) 2003;4(2):192-9.
2003: Melissa D Johnson; Carol Dukes Hamilton; Richard H Drew; Linda L Sanders; Gennethel J Pennick; John R Perfect
A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
The Journal of antimicrobial chemotherapy 2003;51(2):453-7.
2003: Jason C Gallagher; Elizabeth S Dodds Ashley; Richard H Drew; John R Perfect
Antifungal pharmacotherapy for invasive mould infections.
Expert opinion on pharmacotherapy 2003;4(2):147-64.
2003: Gary M Cox; Thomas S Harrison; Henry C McDade; Carlos P Taborda; Garrett Heinrich; Arturo Casadevall; John R Perfect
Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages.
Infection and immunity 2003;71(1):173-80.
2002: Jorge Mora-Duarte; Robert Betts; Coleman Rotstein; Arnaldo Lopes Colombo; Luis Thompson-Moya; Juanita Smietana; Robert J Lupinacci; Carole A Sable; Nicholas A Kartsonis; John R Perfect
Comparison of caspofungin and amphotericin B for invasive candidiasis.
The New England journal of medicine 2002;347(25):2020-9.
2002: John R Perfect; Arturo Casadevall
Cryptococcosis.
Infectious disease clinics of North America 2002;16(4):837-74, v-vi.
2002: Eleftherios Mylonakis; Frederick M Ausubel; John R Perfect; Joseph Heitman; Stephen B Calderwood
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15675-80.
2002: Ann M Loeffler; Richard H Drew; John R Perfect; Nadine I Grethe; J W Stephens; Sharon L Gray; George H Talbot
Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients.
The Pediatric infectious disease journal 2002;21(10):950-6.
2002: Thomas H Rude; Dena L Toffaletti; Gary M Cox; John R Perfect
Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans.
Infection and immunity 2002;70(10):5684-94.
2002: Irene Lu; Elizabeth Dodds; John R Perfect
New antifungal agents.
Seminars in respiratory infections 2002;17(2):140-50.
2002: Ping Wang; Connie B Nichols; Klaus B Lengeler; Maria E Cardenas; Gary M Cox; John R Perfect; Joseph Heitman
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.
Eukaryotic cell 2002;1(2):257-72.
2002: Melanie W Pound; Richard H Drew; John R Perfect
Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumonia.
Current opinion in infectious diseases 2002;15(2):183-94.
2002: THOMAS WALSH; Irja Lutsar; Timothy Driscoll; Bertrand Dupont; Maureen M Roden; Parvis Ghahramani; Michael Hodges; Andreas H Groll; John R Perfect
Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children.
The Pediatric infectious disease journal 2002;21(3):240-8.
2002: M Cristina Cruz; Alan L Goldstein; Jill R Blankenship; Maurizio Del Poeta; Dana Davis; Maria E Cardenas; John R Perfect; John H McCusker; Joseph Heitman
Calcineurin is essential for survival during membrane stress in Candida albicans.
The EMBO journal 2002;21(4):546-59.
2002: J Andrew Alspaugh; Read Pukkila-Worley; Toshiaki Harashima; Lora M Cavallo; Deanna Funnell; Gary M Cox; John R Perfect; James W Kronstad; Joseph Heitman
Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.
Eukaryotic cell 2002;1(1):75-84.
2002: THOMAS WALSH; Peter Pappas; Drew J Winston; Hillard M Lazarus; Finn Petersen; John Raffalli; Saul Yanovich; Patrick J Stiff; Richard Greenberg; Gerald R Donowitz; Mindy Schuster; Annette C Reboli; John R Wingard; Carola Arndt; John Reinhardt; Susan Hadley; Robert Finberg; Michél Laverdière; John R Perfect; Gary Garber; Giuseppe Fioritoni; Eli Anaissie; Jeanette Lee
Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever.
The New England journal of medicine 2002;346(4):225-34.
2002: John R Perfect
New antifungal agents.
Transplant infectious disease : an official journal of the Transplantation Society 2002;4 Suppl 3():52-61.
2002: Denis Hadjiliadis; Thomas A Sporn; John R Perfect; Victor F Tapson; R Duane Davis; Scott M Palmer
Outcome of lung transplantation in patients with mycetomas.
Chest 2002;121(1):128-34.
2002: Jenifer M Gorlach; Henry C McDade; John R Perfect; Gary M Cox
Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.
Microbiology (Reading, England) 2002;148(Pt 1):213-9.
2001: John R Perfect; G M Cox; J Y Lee; Carol A Kauffman; L de Repentigny; Stanley W Chapman; V A Morrison; Paul Pappas; John W Hiemenz; David A Stevens
The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(11):1824-33.
2001: Magnus Gottfredsson; CJ Jessup; Gary M Cox; John R Perfect; Mahmoud A Ghannoum
Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.
Antimicrobial agents and chemotherapy 2001;45(11):3231-3.
2001: M Cristina Cruz; Alan L Goldstein; Jill R Blankenship; Maurizio Del Poeta; John R Perfect; John H McCusker; Youssef Bennani; Maria E Cardenas; Joseph Heitman
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
Antimicrobial agents and chemotherapy 2001;45(11):3162-70.
2001: Peter G Pappas; John R Perfect; Gretchen A Cloud; Robert A Larsen; George A Pankey; Dan Lancaster; H Henderson; Carol A Kauffman; D W Haas; Michael Saccente; Richard J Hamill; Melissa Holloway; R M Warren; William E Dismukes
Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(5):690-9.
2001: Scott M Palmer; Richard H Drew; James D Whitehouse; Victor F Tapson; R Duane Davis; R R McConnell; Souha S Kanj; John R Perfect
Safety of aerosolized amphotericin B lipid complex in lung transplant recipients.
Transplantation 2001;72(3):545-8.
2001: Ping Wang; Maria E Cardenas; Gary M Cox; John R Perfect; Joseph Heitman
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.
EMBO reports 2001;2(6):511-8.
2001: EA Wills; Ian S D Roberts; Maurizio Del Poeta; J Rivera; Arturo Casadevall; Gary M Cox; John R Perfect
Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity.
Molecular microbiology 2001;40(3):610-20.
2001: Cletus A D'Souza; J Andrew Alspaugh; C Yue; Toshiaki Harashima; Gary M Cox; John R Perfect; Joseph Heitman
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
Molecular and cellular biology 2001;21(9):3179-91.
2001: Chiara Luberto; Dena L Toffaletti; EA Wills; S C Tucker; Arturo Casadevall; John R Perfect; Yusuf A Hannun; Maurizio Del Poeta
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.
Genes & development 2001;15(2):201-12.
2001: Gary M Cox; Henry C McDade; S C Chen; S C Tucker; Magnus Gottfredsson; Lesley C Wright; Tania C Sorrell; Steven D Leidich; Arturo Casadevall; Mahmoud A Ghannoum; John R Perfect
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.
Molecular microbiology 2001;39(1):166-75.
2000: Klaus B Lengeler; Ping Wang; Gary M Cox; John R Perfect; Joseph Heitman
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14455-60.
2000: E S Dodds; Richard H Drew; John R Perfect
Antifungal pharmacodynamics: review of the literature and clinical applications.
Pharmacotherapy 2000;20(11):1335-55.
2000: Richard H Drew; John R Perfect; L Srinath; E Kurkimilis; M Dowzicky; George H Talbot
Treatment of methicillin-resistant staphylococcus aureus infections with quinupristin-dalfopristin in patients intolerant of or failing prior therapy. For the Synercid Emergency-Use Study Group.
The Journal of antimicrobial chemotherapy 2000;46(5):775-84.
2000: J Görlach; Deborah S Fox; N Shane Cutler; Gary M Cox; John R Perfect; Joseph Heitman
Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
The EMBO journal 2000;19(14):3618-29.
2000: J Andrew Alspaugh; Lora M Cavallo; John R Perfect; Joseph Heitman
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans.
Molecular microbiology 2000;36(2):352-65.
2000: Michael S Saag; R J Graybill; Robert A Larsen; Peter G Pappas; John R Perfect; William G Powderly; Jack D Sobel; William E Dismukes
Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;30(4):710-8.
2000: Maurizio Del Poeta; M Cristina Cruz; Maria E Cardenas; John R Perfect; Joseph Heitman
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2000;44(3):739-46.
2000: Gary M Cox; J Mukherjee; Garry T Cole; Arturo Casadevall; John R Perfect
Urease as a virulence factor in experimental cryptococcosis.
Infection and immunity 2000;68(2):443-8.
2000: M Cristina Cruz; Maurizio Del Poeta; Ping Wang; R Wenger; Gerhard Zenke; Valerie QUESNIAUX; N Rao Movva; John R Perfect; Maria E Cardenas; Joseph Heitman
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
Antimicrobial agents and chemotherapy 2000;44(1):143-9.
2000: Ping Wang; John R Perfect; Joseph Heitman
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
Molecular and cellular biology 2000;20(1):352-62.
1999: Maurizio Del Poeta; S F Chen; Daniel Von Hoff; Christine C Dykstra; Mansukh C Wani; Govindarajan Manikumar; Joseph Heitman; Monroe E Wall; John R Perfect
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
Antimicrobial agents and chemotherapy 1999;43(12):2862-8.
1999: C Yue; Lora M Cavallo; J Andrew Alspaugh; Ping Wang; Gary M Cox; John R Perfect; Joseph Heitman
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.
Genetics 1999;153(4):1601-15.
1999: Maria E Cardenas; M Cristina Cruz; Maurizio Del Poeta; N Chung; John R Perfect; Joseph Heitman
Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.
Clinical microbiology reviews 1999;12(4):583-611.
1999: Maurizio Del Poeta; A S Bixel; F Barchiesi; Richard R Tidwell; David W Boykin; G Scalise; John R Perfect
In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.
The Journal of antimicrobial chemotherapy 1999;44(2):223-8.
1999: Magnus Gottfredsson; Gary M Cox; Olafur S Indridason; G M de Almeida; A E Heald; John R Perfect
Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.
The Journal of infectious diseases 1999;180(2):534-7.
1999: M Cristina Cruz; Lora M Cavallo; J M Görlach; G Cox; John R Perfect; Maria E Cardenas; Joseph Heitman
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
Molecular and cellular biology 1999;19(6):4101-12.
1999: Maurizio Del Poeta; Dena L Toffaletti; Thomas H Rude; Christine C Dykstra; Joseph Heitman; John R Perfect
Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.
Genetics 1999;152(1):167-78.
1999: Maurizio Del Poeta; Dena L Toffaletti; Thomas H Rude; S D Sparks; Joseph Heitman; John R Perfect
Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein.
Infection and immunity 1999;67(4):1812-20.
1999: Joseph Heitman; Arturo Casadevall; Jennifer lodge; John R Perfect
The Cryptococcus neoformans genome sequencing project.
Mycopathologia 1999;148(1):1-7.
1999: John Ryan Thompson; Cameron M Douglas; W Li; C K Jue; B Pramanik; X Yuan; Thomas H Rude; Dena L Toffaletti; John R Perfect; Myra B Kurtz
A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function.
Journal of bacteriology 1999;181(2):444-53.
1998: Magnus Gottfredsson; Gary M Cox; John R Perfect
Molecular methods for epidemiological and diagnostic studies of fungal infections.
Pathology 1998;30(4):405-18.
1998: Scott M Palmer; John R Perfect; David N Howell; CM Lawrence; AP Miralles; R Duane Davis; Victor F Tapson
Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1998;17(10):1029-33.
1998: J Andrew Alspaugh; John R Perfect; Joseph Heitman
Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.
Fungal genetics and biology : FG & B 1998;25(1):1-14.
1998: Wiley A Schell; G M De Almeida; R K Dodge; K Okonogi; John R Perfect
In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1998;42(10):2630-2.
1998: Maurizio Del Poeta; Wiley A Schell; Christine C Dykstra; Susan Kilgore Jones; Richard R Tidwell; Arvind Kumar; David W Boykin; John R Perfect
In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.
Antimicrobial agents and chemotherapy 1998;42(10):2503-10.
1998: Maurizio Del Poeta; Wiley A Schell; Christine C Dykstra; S Jones; Richard R Tidwell; A Czarny; Miroslav Bajic; Arvind Kumar; David W Boykin; John R Perfect
Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.
Antimicrobial agents and chemotherapy 1998;42(10):2495-502.
1998: Melissa D Johnson; Richard H Drew; John R Perfect
Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature.
Pharmacotherapy 1998;18(5):1053-61.
1998: THOMAS WALSH; John W Hiemenz; Nita L Seibel; John R Perfect; G Horwith; L Lee; J L Silber; M J DiNubile; Annette C Reboli; E Bow; J Lister; Elias J Anaissie
Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;26(6):1383-96.
1998: John R Perfect; Brian Wong; Y C Chang; K J Kwon-Chung; Peter R Williamson
Cryptococcus neoformans: virulence and host defences.
Medical mycology : official publication of the International Society for Human and Animal Mycology 1998;36 Suppl 1():79-86.
1998: Katharine Liu; D N Howell; John R Perfect; Wiley A Schell
Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology.
American journal of clinical pathology 1998;109(1):45-54.
1997: J Andrew Alspaugh; John R Perfect; Joseph Heitman
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
Genes & development 1997;11(23):3206-17.
1997: Dena L Toffaletti; John R Perfect
Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1997;35(5):313-20.
1997: Maurizio Del Poeta; Wiley A Schell; John R Perfect
In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds.
Antimicrobial agents and chemotherapy 1997;41(8):1835-6.
1997: Audrey R Odom; S Muir; E Lim; Dena L Toffaletti; John R Perfect; Joseph Heitman
Calcineurin is required for virulence of Cryptococcus neoformans.
The EMBO journal 1997;16(10):2576-89.
1997: Audrey R Odom; Maurizio Del Poeta; John R Perfect; Joseph Heitman
The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
Antimicrobial agents and chemotherapy 1997;41(1):156-61.
1996: Gary M Cox; Dena L Toffaletti; John R Perfect
Dominant selection system for use in Cryptococcus neoformans.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1996;34(6):385-91.
1996: John R Perfect; Thomas H Rude; Brian Wong; T Flynn; V Chaturvedi; W Niehaus
Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene.
Journal of bacteriology 1996;178(17):5257-62.
1996: John R Perfect; Gary M Cox; R K Dodge; Wiley A Schell
In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1996;40(8):1910-3.
1996: R E Fuller; Richard H Drew; John R Perfect
Treatment of vancomycin-resistant enterococci, with a focus on quinupristin-dalfopristin.
Pharmacotherapy 1996;16(4):584-92.
1996: John R Perfect
Fungal virulence genes as targets for antifungal chemotherapy.
Antimicrobial agents and chemotherapy 1996;40(7):1577-83.
1996: Wiley A Schell; John R Perfect
Fatal, disseminated Acremonium strictum infection in a neutropenic host.
Journal of clinical microbiology 1996;34(5):1333-6.
1996: K Bodily; John R Perfect; G Procop; M K Washington; J Affronti
Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host.
Gastrointestinal endoscopy 1996;43(5):518-21.
1996: John R Perfect; Wiley A Schell
The new fungal opportunists are coming.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1996;22 Suppl 2():S112-8.
1996: AE Heald; Gary M Cox; Wiley A Schell; John A Bartlett; John R Perfect
Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patients receiving long-term continuous versus intermittent fluconazole therapy.
AIDS (London, England) 1996;10(3):263-8.
1995: A Morris; Wiley A Schell; D McDonagh; S Chaffee; John R Perfect
Pneumonia due to Fonsecaea pedrosoi and cerebral abscesses due to Emericella nidulans in a bone marrow transplant recipient.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995;21(5):1346-8.
1995: Thomas G Mitchell; John R Perfect
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.
Clinical microbiology reviews 1995;8(4):515-48.
1995: Gary M Cox; Thomas H Rude; Christine C Dykstra; John R Perfect
The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1995;33(4):261-6.
1994: Gary M Cox; Wiley A Schell; R L Scher; John R Perfect
First report of involvement of Nodulisporium species in human disease.
Journal of clinical microbiology 1994;32(9):2301-4.
1994: John R Perfect; K A Wright
Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.
The Journal of antimicrobial chemotherapy 1994;33(1):73-81.
1993: John R Perfect; N Ketabchi; Gary M Cox; C W Ingram; C L Beiser
Karyotyping of Cryptococcus neoformans as an epidemiological tool.
Journal of clinical microbiology 1993;31(12):3305-9.
1993: C W Ingram; H B Haywood; V M Morris; R L Allen; John R Perfect
Cryptococcal ventricular-peritoneal shunt infection: clinical and epidemiological evaluation of two closely associated cases.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 1993;14(12):719-22.
1993: M L Cameron; Wiley A Schell; S Bruch; John A Bartlett; H A Waskin; John R Perfect
Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1993;37(11):2449-53.
1993: John R Perfect; Dena L Toffaletti; Thomas H Rude
The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.
Infection and immunity 1993;61(10):4446-51.
1993: John R Perfect; D V Savani; D T Durack
Uptake of itraconazole by alveolar macrophages.
Antimicrobial agents and chemotherapy 1993;37(4):903-4.
1993: Dena L Toffaletti; Thomas H Rude; S A Johnston; D T Durack; John R Perfect
Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA.
Journal of bacteriology 1993;175(5):1405-11.
1993: John R Perfect; Wiley A Schell; M G Rinaldi
Uncommon invasive fungal pathogens in the acquired immunodeficiency syndrome.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1993;31(2):175-9.
1992: John R Perfect; Thomas H Rude; L M Penning; S A Johnson
Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae.
Gene 1992;122(1):213-7.
1992: John R Perfect; M H Lindsay; Richard H Drew
Adverse drug reactions to systemic antifungals. Prevention and management.
Drug safety : an international journal of medical toxicology and drug experience 1992;7(5):323-63.
1992: John R Perfect; M E Klotman; C C Gilbert; D D Crawford; Gary Rosner; K A Wright; William P Peters
Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients.
The Journal of infectious diseases 1992;165(5):891-7.
1992: A N Carlson; G N Foulks; John R Perfect; J H Kim
Fungal scleritis after cataract surgery. Successful outcome using itraconazole.
Cornea 1992;11(2):151-4.
1992: S D Goodwin; Jill Fiedler-Kelly; T H Grasela; Wiley A Schell; John R Perfect
A nationwide survey of clinical laboratory methodologies for fungal infections.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1992;30(2):153-60.
1991: John R Perfect
Management of the immunocompromised patient: impact of fungal infections. Introduction.
Reviews of infectious diseases 1991;13(3):473.
1990: K A Wright; John R Perfect; W Ritter
The pharmacokinetics of BAY R3783 and its efficacy in the treatment of experimental cryptococcal meningitis.
The Journal of antimicrobial chemotherapy 1990;26(3):387-97.
1990: Marcia M Hobbs; John R Perfect; Donald L Granger; D T Durack
Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis.
Infection and immunity 1990;58(7):2115-9.
1990: John R Perfect
Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit.
Reviews of infectious diseases 1990;12 Suppl 3():S299-302.
1990: Donald L Granger; J B Hibbs; John R Perfect; D T Durack
Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.
The Journal of clinical investigation 1990;85(1):264-73.
1989: John R Perfect; Marcia M Hobbs; K A Wright; D T Durack
Treatment of experimental disseminated candidiasis with cilofungin.
Antimicrobial agents and chemotherapy 1989;33(10):1811-2.
1989: John R Perfect; K A Wright; Marcia M Hobbs; D T Durack
Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304.
Antimicrobial agents and chemotherapy 1989;33(10):1735-40.
1989: J H Kim; John R Perfect
Infection and cyclosporine.
Reviews of infectious diseases 1989;11(5):677-90.
1989: John R Perfect; Beatrice B Magee; Paul T Magee
Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis.
Infection and immunity 1989;57(9):2624-7.
1989: John R Perfect
Cryptococcosis.
Infectious disease clinics of North America 1989;3(1):77-102.
1989: W Herzog; John R Perfect; L Roberts
Intervertebral diskitis due to Candida tropicalis.
Southern medical journal 1989;82(2):270-3.
1988: SS Yadav; John R Perfect; Allan H Friedman
Successful treatment of cryptococcal ventriculoatrial shunt infection with systemic therapy alone.
Neurosurgery 1988;23(3):372-3.
1988: Richard H Drew; John R Perfect; H A Gallis
Use of fluconazole in a patient with documented malabsorption of ketoconazole.
Clinical pharmacy 1988;7(8):622-3.
1988: John R Perfect; Marcia M Hobbs; Donald L Granger; D T Durack
Cerebrospinal fluid macrophage response to experimental cryptococcal meningitis: relationship between in vivo and in vitro measurements of cytotoxicity.
Infection and immunity 1988;56(4):849-54.
1988: Donald L Granger; J B Hibbs; John R Perfect; D T Durack
Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.
The Journal of clinical investigation 1988;81(4):1129-36.
1987: G J Lallinger; S L Reiner; D W Cooke; Dena L Toffaletti; John R Perfect; D L Granger; D T Durack
Efficacy of immune therapy in early experimental Naegleria fowleri meningitis.
Infection and immunity 1987;55(5):1289-93.
1987: D V Savani; John R Perfect; L M Cobo; D T Durack
Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis.
Antimicrobial agents and chemotherapy 1987;31(1):6-10.
1986: John R Perfect; D V Savani; D T Durack
Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.
Antimicrobial agents and chemotherapy 1986;29(4):579-83.