John Perfect

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Ferwerda Bart; Ferwerda Gerben; Plantinga Theo S; Willment Janet A; van Spriel Annemiek B; Venselaar Hanka; Elbers Clara C; Johnson Melissa D; Cambi Alessandra; Huysamen Cristal; Jacobs Liesbeth; Jansen Trees; Verheijen Karlijn; Masthoff Laury; Morré Servaas A; Vriend Gert; Williams David L; Perfect John R; Joosten Leo A B; Wijmenga Cisca; van der Meer Jos W M; Adema Gosse J; Kullberg Bart Jan; Brown Gordon D; Netea Mihai G
Human dectin-1 deficiency and mucocutaneous fungal infections.
Menzin Joseph; Meyers Juliana L; Friedman Mark; Perfect John R; Langston Amelia A; Danna Robert P; Papadopoulos George
Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients.
Ngamskulrungroj Popchai; Himmelreich Uwe; Breger Julia A; Wilson Christabel; Chayakulkeeree Methee; Krockenberger Mark B; Malik Richard; Daniel Heide-Marie; Toffaletti Dena; Djordjevic Julianne T; Mylonakis Eleftherios; Meyer Wieland; Perfect John R
The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.

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All Publications

2009: Ferwerda Bart; Ferwerda Gerben; Plantinga Theo S; Willment Janet A; van Spriel Annemiek B; Venselaar Hanka; Elbers Clara C; Johnson Melissa D; Cambi Alessandra; Huysamen Cristal; Jacobs Liesbeth; Jansen Trees; Verheijen Karlijn; Masthoff Laury; Morré Servaas A; Vriend Gert; Williams David L; Perfect John R; Joosten Leo A B; Wijmenga Cisca; van der Meer Jos W M; Adema Gosse J; Kullberg Bart Jan; Brown Gordon D; Netea Mihai G
Human dectin-1 deficiency and mucocutaneous fungal infections.
The New England journal of medicine 2009;361(18):1760-7.
2009: Menzin Joseph; Meyers Juliana L; Friedman Mark; Perfect John R; Langston Amelia A; Danna Robert P; Papadopoulos George
Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2009;66(19):1711-7.
2009: Ngamskulrungroj Popchai; Himmelreich Uwe; Breger Julia A; Wilson Christabel; Chayakulkeeree Methee; Krockenberger Mark B; Malik Richard; Daniel Heide-Marie; Toffaletti Dena; Djordjevic Julianne T; Mylonakis Eleftherios; Meyer Wieland; Perfect John R
The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.
Infection and immunity 2009;77(10):4584-96.
2009: Singh Sheena D; Robbins Nicole; Zaas Aimee K; Schell Wiley A; Perfect John R; Cowen Leah E
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.
PLoS pathogens 2009;5(7):e1000532.
2009: Geunes-Boyer Scarlett; Oliver Timothy N; Janbon Guilhem; Lodge Jennifer K; Heitman Joseph; Perfect John R; Wright Jo Rae
Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival.
Infection and immunity 2009;77(7):2783-94.
2009: Dodds Ashley Elizabeth S; Varkey Jay B; Krishna Gopal; Vickery Donna; Ma Lei; Yu Xin; Malavade Darshana; Goodwin Megan; Perfect John R; Power Eddie
Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers.
Antimicrobial agents and chemotherapy 2009;53(7):2960-4.
2009: Naggie Susanna; Perfect John R
Molds: hyalohyphomycosis, phaeohyphomycosis, and zygomycosis.
Clinics in chest medicine 2009;30(2):337-53, vii-viii.
2009: Shapiro Rebecca S; Uppuluri Priya; Zaas Aimee K; Collins Cathy; Senn Heather; Perfect John R; Heitman Joseph; Cowen Leah E
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.
Current biology : CB 2009;19(8):621-9.
2009: Pinchai Nadthanan; Perfect B Zachary; Juvvadi Praveen Rao; Fortwendel Jarrod R; Cramer Robert A; Asfaw Yohannes G; Heitman Joseph; Perfect John R; Steinbach William J
Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.
Eukaryotic cell 2009;8(4):511-9.
2009: Smith Winter J; Drew Richard H; Perfect John R
Posaconazole's impact on prophylaxis and treatment of invasive fungal infections: an update.
Expert review of anti-infective therapy 2009;7(2):165-81.
2009: Caldwell Matthew C; Perfect John R; Carlson Alan N; Proia Alan D
Candida glabrata endophthalmitis following penetrating keratoplasty.
Journal of cataract and refractive surgery 2009;35(3):598-602.
2009: Cowen Leah E; Singh Sheena D; Köhler Julia R; Collins Cathy; Zaas Aimee K; Schell Wiley A; Aziz Hamza; Mylonakis Eleftherios; Perfect John R; Whitesell Luke; Lindquist Susan
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2818-23.
2009: Fortwendel Jarrod R; Juvvadi Praveen Rao; Pinchai Nadthanan; Perfect B Zachary; Alspaugh J Andrew; Perfect John R; Steinbach William J
Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2009;53(2):476-82.
2009: Byrnes Edmond J; Li Wenjun; Lewit Yonathan; Perfect John R; Carter Dee A; Cox Gary M; Heitman Joseph
First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen.
PloS one 2009;4(6):e5851.
2008: Hachem R Y; Langston A A; Graybill J R; Perfect J R; Pedicone L D; Patino H; Raad I I
Posaconazole as salvage treatment of invasive fungal infections in patients with underlying renal impairment.
The Journal of antimicrobial chemotherapy 2008;62(6):1386-91.
2008: Singh Nina; Dromer Francoise; Perfect John R; Lortholary Olivier
Cryptococcosis in solid organ transplant recipients: current state of the science.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(10):1321-7.
2008: Baddley J W; Perfect J R; Oster R A; Larsen R A; Pankey G A; Henderson H; Haas D W; Kauffman C A; Patel R; Zaas A K; Pappas P G
Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2008;27(10):937-43.
2008: Alexander Barbara D; Perfect John R; Daly Jennifer S; Restrepo Angela; Tobón Angela M; Patino Hernando; Hardalo Catherine J; Graybill John R
Posaconazole as salvage therapy in patients with invasive fungal infections after solid organ transplant.
Transplantation 2008;86(6):791-6.
2008: Hu Guanggan; Cheng Po-Yan; Sham Anita; Perfect John R; Kronstad James W
Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection.
Molecular microbiology 2008;69(6):1456-75.
2008: Segal Brahm H; Herbrecht Raoul; Stevens David A; Ostrosky-Zeichner Luis; Sobel Jack; Viscoli Claudio; Walsh Thomas J; Maertens Johan; Patterson Thomas F; Perfect John R; Dupont Bertrand; Wingard John R; Calandra Thierry; Kauffman Carol A; Graybill John R; Baden Lindsey R; Pappas Peter G; Bennett John E; Kontoyiannis Dimitrios P; Cordonnier Catherine; Viviani Maria Anna; Bille Jacques; Almyroudis Nikolaos G; Wheat L Joseph; Graninger Wolfgang; Bow Eric J; Holland Steven M; Kullberg Bart-Jan; Dismukes William E; De Pauw Ben E
Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;47(5):674-83.
2008: Cramer Robert A; Perfect B Zachary; Pinchai Nadthanan; Park Steven; Perlin David S; Asfaw Yohannes G; Heitman Joseph; Perfect John R; Steinbach William J
Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
Eukaryotic cell 2008;7(7):1085-97.
2008: Zaas Aimee K; Liao Guochun; Chien Jason W; Weinberg Clarice; Shore David; Giles Steven S; Marr Kieren A; Usuka Jonathan; Burch Lauranell H; Perera Lalith; Perfect John R; Peltz Gary; Schwartz David A
Plasminogen alleles influence susceptibility to invasive aspergillosis.
PLoS genetics 2008;4(6):e1000101.
2008: Nucci Marcio; Perfect John R
When primary antifungal therapy fails.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1426-33.
2008: Perfect John R
Aerosolized antifungal prophylaxis: the winds of change?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(9):1409-11.
2008: Varkey Jay B; Perfect John R
Rare and emerging fungal pulmonary infections.
Seminars in respiratory and critical care medicine 2008;29(2):121-31.
2008: Kanafani Zeina A; Perfect John R
Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(1):120-8.
2007: Singh Nina; Perfect John R
Immune reconstitution syndrome and exacerbation of infections after pregnancy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(9):1192-9.
2007: Waugh Michael S; Perfect John R; Dash Rajesh C
Schistosoma haematobium in urine: morphology with ThinPrep method.
Diagnostic cytopathology 2007;35(10):649-50.
2007: Chayakulkeeree Methee; Rude Thomas H; Toffaletti Dena L; Perfect John R
Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target.
Antimicrobial agents and chemotherapy 2007;51(10):3537-45.
2007: Onyewu Chiatogu; Eads Emily; Schell Wiley A; Perfect John R; Ullmann Yehuda; Kaufman Gil; Horwitz Benjamin A; Berdicevsky Israela; Heitman Joseph
Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
Antimicrobial agents and chemotherapy 2007;51(10):3743-6.
2007: Steinbach William J; Cramer Robert A; Perfect B Zachary; Henn Christina; Nielsen Kirsten; Heitman Joseph; Perfect John R
Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2007;51(8):2979-81.
2007: Steinbach William J; Addison Rachel M; McLaughlin Lisa; Gerrald Quincy; Martin Paul L; Driscoll Timothy; Bentsen Christopher; Perfect John R; Alexander Barbara D
Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients.
The Pediatric infectious disease journal 2007;26(7):558-64.
2007: Singh Nina; Perfect John R
Immune reconstitution syndrome associated with opportunistic mycoses.
The Lancet infectious diseases 2007;7(6):395-401.
2007: Steinbach William J; Reedy Jennifer L; Cramer Robert A; Perfect John R; Heitman Joseph
Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
Nature reviews. Microbiology 2007;5(6):418-30.
2007: Wormley Floyd L; Perfect John R; Steele Chad; Cox Gary M
Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.
Infection and immunity 2007;75(3):1453-62.
2007: Alexander Barbara D; Byrne Terry C; Smith Kelly L; Hanson Kimberly E; Anstrom Kevin J; Perfect John R; Reller L Barth
Comparative evaluation of Etest and sensititre yeastone panels against the Clinical and Laboratory Standards Institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents.
Journal of clinical microbiology 2007;45(3):698-706.
2007: Dodds Ashley E S; Zaas A K; Fang A F; Damle B; Perfect J R
Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets.
Antimicrobial agents and chemotherapy 2007;51(3):877-80.
2007: Perfect John R
Management of cryptococcosis: how are we doing?
PLoS medicine 2007;4(2):e47.
2007: Segal Brahm H; Almyroudis Nikolaos G; Battiwalla Minoo; Herbrecht Raoul; Perfect John R; Walsh Thomas J; Wingard John R
Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;44(3):402-9.
2007: Cornely Oliver A; Maertens Johan; Winston Drew J; Perfect John; Ullmann Andrew J; Walsh Thomas J; Helfgott David; Holowiecki Jerzy; Stockelberg Dick; Goh Yeow-Tee; Petrini Mario; Hardalo Cathy; Suresh Ramachandran; Angulo-Gonzalez David
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.
The New England journal of medicine 2007;356(4):348-59.
2007: Walsh Thomas J; Raad Issam; Patterson Thomas F; Chandrasekar Pranatharthi; Donowitz Gerald R; Graybill Richard; Greene Reginald E; Hachem Ray; Hadley Susan; Herbrecht Raoul; Langston Amelia; Louie Arnold; Ribaud Patricia; Segal Brahm H; Stevens David A; van Burik Jo-Anne H; White Charles S; Corcoran Gavin; Gogate Jagadish; Krishna Gopal; Pedicone Lisa; Hardalo Catherine; Perfect John R
Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;44(1):2-12.
2007: Idnurm Alexander; Giles Steven S; Perfect John R; Heitman Joseph
Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans.
Eukaryotic cell 2007;6(1):60-72.
2007: Giles Steven S; Zaas Aimee K; Reidy Mike F; Perfect John R; Wright Jo Rae
Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.
PloS one 2007;2(12):e1370.
2006: Zaas Aimee K; Dodds Ashley Elizabeth S; Alexander Barbara D; Johnson Melissa D; Perfect John R
Caspofungin for invasive candidiasis at a tertiary care medical center.
The American journal of medicine 2006;119(11):993.e1-6.
2006: Cramer Robert A; Stajich Jason E; Yamanaka Yvonne; Dietrich Fred S; Steinbach William J; Perfect John R
Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.
Gene 2006;383():24-32.
2006: Petzold Elizabeth Wills; Himmelreich Uwe; Mylonakis Eleftherios; Rude Thomas; Toffaletti Dena; Cox Gary M; Miller Jackie L; Perfect John R
Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.
Infection and immunity 2006;74(10):5877-87.
2006: Chayakulkeeree Methee; Perfect John R
Cryptococcosis.
Infectious disease clinics of North America 2006;20(3):507-44, v-vi.
2006: Giles Steven S; Stajich Jason E; Nichols Connie; Gerrald Quincy D; Alspaugh J Andrew; Dietrich Fred; Perfect John R
The Cryptococcus neoformans catalase gene family and its role in antioxidant defense.
Eukaryotic cell 2006;5(9):1447-59.
2006: Steinbach William J; Cramer Robert A; Perfect B Zachary; Asfaw Yohannes G; Sauer Theodor C; Najvar Laura K; Kirkpatrick William R; Patterson Thomas F; Benjamin Daniel K; Heitman Joseph; Perfect John R
Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
Eukaryotic cell 2006;5(7):1091-103.
2006: Cramer Robert A; Gamcsik Michael P; Brooking Rhea M; Najvar Laura K; Kirkpatrick William R; Patterson Thomas F; Balibar Carl J; Graybill John R; Perfect John R; Abraham Soman N; Steinbach William J
Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.
Eukaryotic cell 2006;5(6):972-80.
2006: Raad Issam I; Graybill John R; Bustamante Ana Beatriz; Cornely Oliver A; Gaona-Flores Veronica; Afif Claude; Graham Donald R; Greenberg Richard N; Hadley Susan; Langston Amelia; Negroni Ricardo; Perfect John R; Pitisuttithum Punnee; Restrepo Angela; Schiller Gary; Pedicone Lisa; Ullmann Andrew J
Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(12):1726-34.
2006: Perfect John R
Cryptococcus neoformans: the yeast that likes it hot.
FEMS yeast research 2006;6(4):463-8.
2006: Turner Michelle S; Drew Richard H; Perfect John R
Emerging echinocandins for treatment of invasive fungal infections.
Expert opinion on emerging drugs 2006;11(2):231-50.
2006: Chayakulkeeree M; Ghannoum M A; Perfect J R
Zygomycosis: the re-emerging fungal infection.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2006;25(4):215-29.
2006: Alexander B D; Dodds Ashley E S; Addison R M; Alspaugh J A; Chao N J; Perfect J R
Non-comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation.
Transplant infectious disease : an official journal of the Transplantation Society 2006;8(1):13-20.
2005: Ribeiro Mariceli A; Paula C R; John R; Perfect John R; Cox Gary M
Phenotypic and genotypic evaluation of fluconazole resistance in vaginal Candida strains isolated from HIV-infected women from Brazil.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43(7):647-50.
2005: Bahn Yong-Sun; Cox Gary M; Perfect John R; Heitman Joseph
Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence.
Current biology : CB 2005;15(22):2013-20.
2005: Steinbach William J; Perfect John R; Cabell Christopher H; Fowler Vance G; Corey G Ralph; Li Jennifer S; Zaas Aimee K; Benjamin Daniel K
A meta-analysis of medical versus surgical therapy for Candida endocarditis.
The Journal of infection 2005;51(3):230-47.
2005: Fraser James A; Giles Steven S; Wenink Emily C; Geunes-Boyer Scarlett G; Wright Jo Rae; Diezmann Stephanie; Allen Andria; Stajich Jason E; Dietrich Fred S; Perfect John R; Heitman Joseph
Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak.
Nature 2005;437(7063):1360-4.
2005: Alexander Barbara D; Schell Wiley A; Miller Jackie L; Long Gwynn D; Perfect John R
Candida glabrata fungemia in transplant patients receiving voriconazole after fluconazole.
Transplantation 2005;80(6):868-71.
2005: Perfect John R
Cryptococcus neoformans: a sugar-coated killer with designer genes.
FEMS immunology and medical microbiology 2005;45(3):395-404.
2005: Wormley F L; Heinrich G; Miller J L; Perfect J R; Cox G M
Identification and characterization of an SKN7 homologue in Cryptococcus neoformans.
Infection and immunity 2005;73(8):5022-30.
2005: Nielsen Kirsten; Cox Gary M; Litvintseva Anastasia P; Mylonakis Eleftherios; Malliaris Stephanie D; Benjamin Daniel K; Giles Steven S; Mitchell Thomas G; Casadevall Arturo; Perfect John R; Heitman Joseph
Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection.
Infection and immunity 2005;73(8):4922-33.
2005: Chang Christopher Y; Schell Wiley A; Perfect John R; Hulka Gregory F
Novel use of a swimming pool biocide in the treatment of a rare fungal mastoiditis.
The Laryngoscope 2005;115(6):1065-9.
2005: Perfect J R
Nuances of new anti-Aspergillus antifungals.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43 Suppl 1():S271-6.
2005: Drew Richard H; Arthur Rebekah R; Perfect John R
Is it time to abandon the use of amphotericin B bladder irrigation?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40(10):1465-70.
2005: Baddour Larry M; Perfect John R; Ostrosky-Zeichner Luis
Successful use of amphotericin B lipid complex in the treatment of cryptococcosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40 Suppl 6():S409-13.
2005: Perfect John R
Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;40 Suppl 6():S401-8.
2005: Gibbs Winter J; Drew Richard H; Perfect John R
Liposomal amphotericin B: clinical experience and perspectives.
Expert review of anti-infective therapy 2005;3(2):167-81.
2005: Larsen Robert A; Pappas Peter G; Perfect John; Aberg Judith A; Casadevall Arturo; Cloud Gretchen A; James Robert; Filler Scott; Dismukes William E
Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis.
Antimicrobial agents and chemotherapy 2005;49(3):952-8.
2005: Wormley Floyd L; Cox Gary M; Perfect John R
Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.
Microbial pathogenesis 2005;38(2-3):113-23.
2005: Venkatesan Priya; Perfect John R; Myers Sarah A
Evaluation and management of fungal infections in immunocompromised patients.
Dermatologic therapy 2005;18(1):44-57.
2005: Giles Steven S; Batinic-Haberle Ines; Perfect John R; Cox Gary M
Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.
Eukaryotic cell 2005;4(1):46-54.
2005: Giles Steven S; Perfect John R; Cox Gary M
Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.
Fungal genetics and biology : FG & B 2005;42(1):20-9.
2005: Wormley Floyd L; Perfect John R
Immunology of infection caused by Cryptococcus neoformans.
Methods in molecular medicine 2005;118():193-8.
2004: Perfect John R
Antifungal resistance: the clinical front.
Oncology (Williston Park, N.Y.) 2004;18(14 Suppl 13):15-22.
2004: Steinbach William J; Singh Nina; Miller Jackie L; Benjamin Daniel K; Schell Wiley A; Heitman Joseph; Perfect John R
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
Antimicrobial agents and chemotherapy 2004;48(12):4922-5.
2004: Onyewu Chiatogu; Wormley Floyd L; Perfect John R; Heitman Joseph
The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
Infection and immunity 2004;72(12):7330-3.
2004: Perfect John R
Use of newer antifungal therapies in clinical practice: what do the data tell us?
Oncology (Williston Park, N.Y.) 2004;18(13 Suppl 7):15-23.
2004: Perfect John R
Management of invasive mycoses in hematology patients: current approaches.
Oncology (Williston Park, N.Y.) 2004;18(13 Suppl 7):5-14.
2004: Steinbach William J; Benjamin Daniel K; Trasi Scott A; Miller Jackie L; Schell Wiley A; Zaas Aimee K; Foster W Michael; Perfect John R
Value of an inhalational model of invasive aspergillosis.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2004;42(5):417-25.
2004: Perfect John R; Dodds Ashley Elizabeth; Drew Richard
Design of aerosolized amphotericin b formulations for prophylaxis trials among lung transplant recipients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39 Suppl 4():S207-10.
2004: Jiménez-Expósito M J; Torres G; Baraldés A; Benito N; Marco F; Paré J C; Moreno A; Claramonte X; Mestres C A; Almela M; García de la María C; Pérez N; Schell W A; Corey G R; Perfect J; Jiménez de Anta M T; Gatell J M; Miró J M
Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(7):e70-3.
2004: Kraus Peter R; Boily Marie-Josée; Giles Steven S; Stajich Jason E; Allen Andria; Cox Gary M; Dietrich Fred S; Perfect John R; Heitman Joseph
Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.
Eukaryotic cell 2004;3(5):1249-60.
2004: Toffaletti Dena L; Nielsen Kirsten; Dietrich Fred; Heitman Joseph; Perfect John R
Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence.
Current genetics 2004;46(4):193-204.
2004: Steinbach William J; Perfect John R; Schell Wiley A; Walsh Thomas J; Benjamin Daniel K
In vitro analyses, animal models, and 60 clinical cases of invasive Aspergillus terreus infection.
Antimicrobial agents and chemotherapy 2004;48(9):3217-25.
2004: Miwa Takuya; Takagi Yukinobu; Shinozaki Makiko; Yun Cheol-Won; Schell Wiley A; Perfect John R; Kumagai Hidehiko; Tamaki Hisanori
Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.
Eukaryotic cell 2004;3(4):919-31.
2004: Arthur Rebekah R; Drew Richard H; Perfect John R
Novel modes of antifungal drug administration.
Expert opinion on investigational drugs 2004;13(8):903-32.
2004: Steinbach William J; Benjamin Daniel K; Kontoyiannis Dimitrios P; Perfect John R; Lutsar Irja; Marr Kieren A; Lionakis Michail S; Torres Harrys A; Jafri Hasan; Walsh Thomas J
Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004;39(2):192-8.
2004: Olszewski Michal A; Noverr Mairi C; Chen Gwo-Hsiao; Toews Galen B; Cox Gary M; Perfect John R; Huffnagle Gary B
Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion.
The American journal of pathology 2004;164(5):1761-71.
2004: Steinbach William J; Schell Wiley A; Blankenship Jill R; Onyewu Chiatogu; Heitman Joseph; Perfect John R
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
Antimicrobial agents and chemotherapy 2004;48(5):1664-9.
2004: Gallagher Jason C; MacDougall Conan; Ashley Elizabeth S Dodds; Perfect John R
Recent advances in antifungal pharmacotherapy for invasive fungal infections.
Expert review of anti-infective therapy 2004;2(2):253-68.
2004: Lodge Barbara Alexander; Ashley Elizabeth Dodds; Steele Mark P; Perfect John R
Aspergillus fumigatus empyema, arthritis, and calcaneal osteomyelitis in a lung transplant patient successfully treated with posaconazole.
Journal of clinical microbiology 2004;42(3):1376-8.
2004: Johnson Melissa D; MacDougall Conan; Ostrosky-Zeichner Luis; Perfect John R; Rex John H
Combination antifungal therapy.
Antimicrobial agents and chemotherapy 2004;48(3):693-715.
2004: Miller J L; Schell W A; Wills E A; Toffaletti D L; Boyce M; Benjamin D K; Bartroli J; Perfect J R
In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2004;48(2):384-7.
2004: Drew Richard H; Dodds Ashley Elizabeth; Benjamin Daniel K; Duane Davis R; Palmer Scott M; Perfect John R
Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients.
Transplantation 2004;77(2):232-7.
2004: Steinbach W J; Schell W A; Miller J L; Perfect J R; Martin P L
Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients.
The Journal of infection 2004;48(1):112-6.
2004: Benjamin Daniel K; Miro Jose M; Hoen Bruno; Steinbach William J; Fowler Vance G; Olaison Lars; Habib Gilbert; Abrutyn Elias; Perfect John; Zass Amy; Corey G Ralph; Eykyn Susannah; Thuny Franck; Jiménez-Expósito María-Jesús; Cabell Christopher H;
Candida endocarditis: contemporary cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-mD).
Scandinavian journal of infectious diseases 2004;36(6-7):453-5.
2003: Steinbach William J; Mitchell Thomas G; Schell Wiley A; Espinel-Ingroff Ana; Coico Richard F; Walsh Thomas J; Perfect John R
Status of medical mycology education.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2003;41(6):457-67.
2003: Steinbach W J; Perfect J R
Scedosporium species infections and treatments.
Journal of chemotherapy (Florence, Italy) 2003;15 Suppl 2():16-27.
2003: Zaas Aimee K; Boyce Molly; Schell Wiley; Lodge Barbara Alexander; Miller Jackie L; Perfect John R
Risk of fungemia due to Rhodotorula and antifungal susceptibility testing of Rhodotorula isolates.
Journal of clinical microbiology 2003;41(11):5233-5.
2003: Luberto Chiara; Martinez-Mariño Beatriz; Taraskiewicz Daniel; Bolaños Benjamin; Chitano Pasquale; Toffaletti Dena L; Cox Gary M; Perfect John R; Hannun Yusuf A; Balish Edward; Del Poeta Maurizio
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.
The Journal of clinical investigation 2003;112(7):1080-94.
2003: Akhter Shamima; McDade Henry C; Gorlach Jenifer M; Heinrich Garrett; Cox Gary M; Perfect John R
Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans.
Infection and immunity 2003;71(10):5794-802.
2003: Nielsen Kirsten; Cox Gary M; Wang Ping; Toffaletti Dena L; Perfect John R; Heitman Joseph
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates.
Infection and immunity 2003;71(9):4831-41.
2003: Trinh Jane V; Steinbach William J; Schell Wiley A; Kurtzberg Joanne; Giles Steven S; Perfect John R
Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2003;41(4):339-45.
2003: Steinbach William J; Schell Wiley A; Miller Jackie L; Perfect John R
Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide.
Journal of clinical microbiology 2003;41(8):3981-5.
2003: Colombo A L; Perfect J; DiNubile M; Bartizal K; Motyl M; Hicks P; Lupinacci R; Sable C; Kartsonis N
Global distribution and outcomes for Candida species causing invasive candidiasis: results from an international randomized double-blind study of caspofungin versus amphotericin B for the treatment of invasive candidiasis.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2003;22(8):470-4.
2003: Gottfredsson Magnús; Vredenburgh James J; Xu Jianping; Schell Wiley A; Perfect John R
Candidemia in women with breast carcinoma treated with high-dose chemotherapy and autologous bone marrow transplantation.
Cancer 2003;98(1):24-30.
2003: Davidson Robert C; Nichols Connie B; Cox Gary M; Perfect John R; Heitman Joseph
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans.
Molecular microbiology 2003;49(2):469-85.
2003: Blankenship Jill R; Wormley Floyd L; Boyce Molly K; Schell Wiley A; Filler Scott G; Perfect John R; Heitman Joseph
Calcineurin is essential for Candida albicans survival in serum and virulence.
Eukaryotic cell 2003;2(3):422-30.
2003: Johnson Melissa D; Perfect John R
Caspofungin: first approved agent in a new class of antifungals.
Expert opinion on pharmacotherapy 2003;4(5):807-23.
2003: Perfect John R; Marr Kieren A; Walsh Thomas J; Greenberg Richard N; DuPont Bertrand; de la Torre-Cisneros Juliàn; Just-Nübling Gudrun; Schlamm Haran T; Lutsar Irja; Espinel-Ingroff Ana; Johnson Elizabeth
Voriconazole treatment for less-common, emerging, or refractory fungal infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2003;36(9):1122-31.
2003: Toffaletti Dena L; Del Poeta Maurizio; Rude Thomas H; Dietrich Fred; Perfect John R
Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.
Microbiology (Reading, England) 2003;149(Pt 4):1041-9.
2003: Steinbach William J; Perfect John R
Newer antifungal therapy for emerging fungal pathogens.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2003;7(1):5-20.
2003: Noverr Mairi C; Cox Gary M; Perfect John R; Huffnagle Gary B
Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production.
Infection and immunity 2003;71(3):1538-47.
2003: Blankenship Jill R; Steinbach William J; Perfect John R; Heitman Joseph
Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.
Current opinion in investigational drugs (London, England : 2000) 2003;4(2):192-9.
2003: Johnson Melissa D; Hamilton Carol D; Drew Richard H; Sanders Linda L; Pennick Gennethel J; Perfect John R
A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
The Journal of antimicrobial chemotherapy 2003;51(2):453-7.
2003: Gallagher Jason C; Dodds Ashley Elizabeth S; Drew Richard H; Perfect John R
Antifungal pharmacotherapy for invasive mould infections.
Expert opinion on pharmacotherapy 2003;4(2):147-64.
2003: Cox Gary M; Harrison Thomas S; McDade Henry C; Taborda Carlos P; Heinrich Garrett; Casadevall Arturo; Perfect John R
Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages.
Infection and immunity 2003;71(1):173-80.
2002: Perfect John R; Casadevall Arturo
Cryptococcosis.
Infectious disease clinics of North America 2002;16(4):837-74, v-vi.
2002: Mora-Duarte Jorge; Betts Robert; Rotstein Coleman; Colombo Arnaldo Lopes; Thompson-Moya Luis; Smietana Juanita; Lupinacci Robert; Sable Carole; Kartsonis Nicholas; Perfect John;
Comparison of caspofungin and amphotericin B for invasive candidiasis.
The New England journal of medicine 2002;347(25):2020-9.
2002: Mylonakis Eleftherios; Ausubel Frederick M; Perfect John R; Heitman Joseph; Calderwood Stephen B
Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15675-80.
2002: Loeffler Ann M; Drew Richard H; Perfect John R; Grethe Nadine I; Stephens J W; Gray Sharon L; Talbot George H
Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients.
The Pediatric infectious disease journal 2002;21(10):950-6.
2002: Rude Thomas H; Toffaletti Dena L; Cox Gary M; Perfect John R
Relationship of the glyoxylate pathway to the pathogenesis of Cryptococcus neoformans.
Infection and immunity 2002;70(10):5684-94.
2002: Lu Irene; Dodds Elizabeth; Perfect John
New antifungal agents.
Seminars in respiratory infections 2002;17(2):140-50.
2002: Wang Ping; Nichols Connie B; Lengeler Klaus B; Cardenas Maria E; Cox Gary M; Perfect John R; Heitman Joseph
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans.
Eukaryotic cell 2002;1(2):257-72.
2002: Pound Melanie W; Drew Richard H; Perfect John R
Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumonia.
Current opinion in infectious diseases 2002;15(2):183-94.
2002: Walsh Thomas J; Lutsar Irja; Driscoll Timothy; Dupont Bertrand; Roden Maureen; Ghahramani Parvis; Hodges Michael; Groll Andreas H; Perfect John R
Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children.
The Pediatric infectious disease journal 2002;21(3):240-8.
2002: Alspaugh J Andrew; Pukkila-Worley Read; Harashima Toshiaki; Cavallo Lora M; Funnell Deanna; Cox Gary M; Perfect John R; Kronstad James W; Heitman Joseph
Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.
Eukaryotic cell 2002;1(1):75-84.
2002: Cruz M Cristina; Goldstein Alan L; Blankenship Jill R; Del Poeta Maurizio; Davis Dana; Cardenas Maria E; Perfect John R; McCusker John H; Heitman Joseph
Calcineurin is essential for survival during membrane stress in Candida albicans.
The EMBO journal 2002;21(4):546-59.
2002: Walsh Thomas J; Pappas Peter; Winston Drew J; Lazarus Hillard M; Petersen Finn; Raffalli John; Yanovich Saul; Stiff Patrick; Greenberg Richard; Donowitz Gerald; Schuster Mindy; Reboli Annette; Wingard John; Arndt Carola; Reinhardt John; Hadley Susan; Finberg Robert; Laverdière Michél; Perfect John; Garber Gary; Fioritoni Giuseppe; Anaissie Eli; Lee Jeanette;
Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever.
The New England journal of medicine 2002;346(4):225-34.
2002: Hadjiliadis Denis; Sporn Thomas A; Perfect John R; Tapson Victor F; Davis R Duane; Palmer Scott M
Outcome of lung transplantation in patients with mycetomas.
Chest 2002;121(1):128-34.
2002: Gorlach Jenifer M; McDade Henry C; Perfect John R; Cox Gary M
Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.
Microbiology (Reading, England) 2002;148(Pt 1):213-9.
2002: Perfect J R
New antifungal agents.
Transplant infectious disease : an official journal of the Transplantation Society 2002;4 Suppl 3():52-61.
2001: Perfect J R; Cox G M; Lee J Y; Kauffman C A; de Repentigny L; Chapman S W; Morrison V A; Pappas P; Hiemenz J W; Stevens D A;
The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(11):1824-33.
2001: Gottfredsson M; Jessup C J; Cox G M; Perfect J R; Ghannoum M A
Fungal phospholipase activity and susceptibility to lipid preparations of amphotericin B.
Antimicrobial agents and chemotherapy 2001;45(11):3231-3.
2001: Cruz M C; Goldstein A L; Blankenship J; Del Poeta M; Perfect J R; McCusker J H; Bennani Y L; Cardenas M E; Heitman J
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
Antimicrobial agents and chemotherapy 2001;45(11):3162-70.
2001: Pappas P G; Perfect J R; Cloud G A; Larsen R A; Pankey G A; Lancaster D J; Henderson H; Kauffman C A; Haas D W; Saccente M; Hamill R J; Holloway M S; Warren R M; Dismukes W E
Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2001;33(5):690-9.
2001: Palmer S M; Drew R H; Whitehouse J D; Tapson V F; Davis R D; McConnell R R; Kanj S S; Perfect J R
Safety of aerosolized amphotericin B lipid complex in lung transplant recipients.
Transplantation 2001;72(3):545-8.
2001: Wang P; Cardenas M E; Cox G M; Perfect J R; Heitman J
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.
EMBO reports 2001;2(6):511-8.
2001: Wills E A; Roberts I S; Del Poeta M; Rivera J; Casadevall A; Cox G M; Perfect J R
Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity.
Molecular microbiology 2001;40(3):610-20.
2001: D'Souza C A; Alspaugh J A; Yue C; Harashima T; Cox G M; Perfect J R; Heitman J
Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
Molecular and cellular biology 2001;21(9):3179-91.
2001: Luberto C; Toffaletti D L; Wills E A; Tucker S C; Casadevall A; Perfect J R; Hannun Y A; Del Poeta M
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.
Genes & development 2001;15(2):201-12.
2001: Cox G M; McDade H C; Chen S C; Tucker S C; Gottfredsson M; Wright L C; Sorrell T C; Leidich S D; Casadevall A; Ghannoum M A; Perfect J R
Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans.
Molecular microbiology 2001;39(1):166-75.
2000: Lengeler K B; Wang P; Cox G M; Perfect J R; Heitman J
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14455-60.
2000: Dodds E S; Drew R H; Perfect J R
Antifungal pharmacodynamics: review of the literature and clinical applications.
Pharmacotherapy 2000;20(11):1335-55.
2000: Drew R H; Perfect J R; Srinath L; Kurkimilis E; Dowzicky M; Talbot G H
Treatment of methicillin-resistant staphylococcus aureus infections with quinupristin-dalfopristin in patients intolerant of or failing prior therapy. For the Synercid Emergency-Use Study Group.
The Journal of antimicrobial chemotherapy 2000;46(5):775-84.
2000: Görlach J; Fox D S; Cutler N S; Cox G M; Perfect J R; Heitman J
Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
The EMBO journal 2000;19(14):3618-29.
2000: Alspaugh J A; Cavallo L M; Perfect J R; Heitman J
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans.
Molecular microbiology 2000;36(2):352-65.
2000: Saag M S; Graybill R J; Larsen R A; Pappas P G; Perfect J R; Powderly W G; Sobel J D; Dismukes W E
Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;30(4):710-8.
2000: Del Poeta M; Cruz M C; Cardenas M E; Perfect J R; Heitman J
Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 2000;44(3):739-46.
2000: Cox G M; Mukherjee J; Cole G T; Casadevall A; Perfect J R
Urease as a virulence factor in experimental cryptococcosis.
Infection and immunity 2000;68(2):443-8.
2000: Cruz M C; Del Poeta M; Wang P; Wenger R; Zenke G; Quesniaux V F; Movva N R; Perfect J R; Cardenas M E; Heitman J
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
Antimicrobial agents and chemotherapy 2000;44(1):143-9.
2000: Wang P; Perfect J R; Heitman J
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
Molecular and cellular biology 2000;20(1):352-62.
1999: Del Poeta M; Chen S F; Von Hoff D; Dykstra C C; Wani M C; Manikumar G; Heitman J; Wall M E; Perfect J R
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
Antimicrobial agents and chemotherapy 1999;43(12):2862-8.
1999: Yue C; Cavallo L M; Alspaugh J A; Wang P; Cox G M; Perfect J R; Heitman J
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans.
Genetics 1999;153(4):1601-15.
1999: Cardenas M E; Cruz M C; Del Poeta M; Chung N; Perfect J R; Heitman J
Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.
Clinical microbiology reviews 1999;12(4):583-611.
1999: Del Poeta M; Bixel A S; Barchiesi F; Tidwell R R; Boykin D; Scalise G; Perfect J R
In-vitro activity of dicationic aromatic compounds and fluconazole against Cryptococcus neoformans and Candida spp.
The Journal of antimicrobial chemotherapy 1999;44(2):223-8.
1999: Gottfredsson M; Cox G M; Indridason O S; de Almeida G M; Heald A E; Perfect J R
Association of plasma levels of human immunodeficiency virus type 1 RNA and oropharyngeal Candida colonization.
The Journal of infectious diseases 1999;180(2):534-7.
1999: Cruz M C; Cavallo L M; Görlach J M; Cox G; Perfect J R; Cardenas M E; Heitman J
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
Molecular and cellular biology 1999;19(6):4101-12.
1999: Del Poeta M; Toffaletti D L; Rude T H; Dykstra C C; Heitman J; Perfect J R
Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.
Genetics 1999;152(1):167-78.
1999: del Poeta M; Toffaletti D L; Rude T H; Sparks S D; Heitman J; Perfect J R
Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein.
Infection and immunity 1999;67(4):1812-20.
1999: Thompson J R; Douglas C M; Li W; Jue C K; Pramanik B; Yuan X; Rude T H; Toffaletti D L; Perfect J R; Kurtz M
A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function.
Journal of bacteriology 1999;181(2):444-53.
1999: Heitman J; Casadevall A; Lodge J K; Perfect J R
The Cryptococcus neoformans genome sequencing project.
Mycopathologia 1999;148(1):1-7.
1998: Gottfredsson M; Cox G M; Perfect J R
Molecular methods for epidemiological and diagnostic studies of fungal infections.
Pathology 1998;30(4):405-18.
1998: Palmer S M; Perfect J R; Howell D N; Lawrence C M; Miralles A P; Davis R D; Tapson V F
Candidal anastomotic infection in lung transplant recipients: successful treatment with a combination of systemic and inhaled antifungal agents.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1998;17(10):1029-33.
1998: Alspaugh J A; Perfect J R; Heitman J
Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.
Fungal genetics and biology : FG & B 1998;25(1):1-14.
1998: Schell W A; De Almeida G M; Dodge R K; Okonogi K; Perfect J R
In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1998;42(10):2630-2.
1998: Del Poeta M; Schell W A; Dykstra C C; Jones S K; Tidwell R R; Kumar A; Boykin D W; Perfect J R
In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles.
Antimicrobial agents and chemotherapy 1998;42(10):2503-10.
1998: Del Poeta M; Schell W A; Dykstra C C; Jones S; Tidwell R R; Czarny A; Bajic M; Kumar A; Boykin D; Perfect J R
Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents.
Antimicrobial agents and chemotherapy 1998;42(10):2495-502.
1998: Johnson M D; Drew R H; Perfect J R
Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature.
Pharmacotherapy 1998;18(5):1053-61.
1998: Walsh T J; Hiemenz J W; Seibel N L; Perfect J R; Horwith G; Lee L; Silber J L; DiNubile M J; Reboli A; Bow E; Lister J; Anaissie E J
Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;26(6):1383-96.
1998: Liu K; Howell D N; Perfect J R; Schell W A
Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology.
American journal of clinical pathology 1998;109(1):45-54.
1998: Perfect J R; Wong B; Chang Y C; Kwon-Chung K J; Williamson P R
Cryptococcus neoformans: virulence and host defences.
Medical mycology : official publication of the International Society for Human and Animal Mycology 1998;36 Suppl 1():79-86.
1997: Alspaugh J A; Perfect J R; Heitman J
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
Genes & development 1997;11(23):3206-17.
1997: Toffaletti D L; Perfect J R
Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1997;35(5):313-20.
1997: Del Poeta M; Schell W A; Perfect J R
In vitro antifungal activity of pneumocandin L-743,872 against a variety of clinically important molds.
Antimicrobial agents and chemotherapy 1997;41(8):1835-6.
1997: Odom A; Muir S; Lim E; Toffaletti D L; Perfect J; Heitman J
Calcineurin is required for virulence of Cryptococcus neoformans.
The EMBO journal 1997;16(10):2576-89.
1997: Odom A; Del Poeta M; Perfect J; Heitman J
The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
Antimicrobial agents and chemotherapy 1997;41(1):156-61.
1996: Cox G M; Toffaletti D L; Perfect J R
Dominant selection system for use in Cryptococcus neoformans.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1996;34(6):385-91.
1996: Perfect J R; Rude T H; Wong B; Flynn T; Chaturvedi V; Niehaus W
Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene.
Journal of bacteriology 1996;178(17):5257-62.
1996: Perfect J R; Cox G M; Dodge R K; Schell W A
In vitro and in vivo efficacies of the azole SCH56592 against Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1996;40(8):1910-3.
1996: Fuller R E; Drew R H; Perfect J R
Treatment of vancomycin-resistant enterococci, with a focus on quinupristin-dalfopristin.
Pharmacotherapy 1996;16(4):584-92.
1996: Perfect J R
Fungal virulence genes as targets for antifungal chemotherapy.
Antimicrobial agents and chemotherapy 1996;40(7):1577-83.
1996: Schell W A; Perfect J R
Fatal, disseminated Acremonium strictum infection in a neutropenic host.
Journal of clinical microbiology 1996;34(5):1333-6.
1996: Bodily K; Perfect J R; Procop G; Washington M K; Affronti J
Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host.
Gastrointestinal endoscopy 1996;43(5):518-21.
1996: Perfect J R; Schell W A
The new fungal opportunists are coming.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1996;22 Suppl 2():S112-8.
1996: Heald A E; Cox G M; Schell W A; Bartlett J A; Perfect J R
Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patients receiving long-term continuous versus intermittent fluconazole therapy.
AIDS (London, England) 1996;10(3):263-8.
1995: Morris A; Schell W A; McDonagh D; Chaffee S; Perfect J R
Pneumonia due to Fonsecaea pedrosoi and cerebral abscesses due to Emericella nidulans in a bone marrow transplant recipient.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995;21(5):1346-8.
1995: Mitchell T G; Perfect J R
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.
Clinical microbiology reviews 1995;8(4):515-48.
1995: Cox G M; Rude T H; Dykstra C C; Perfect J R
The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1995;33(4):261-6.
1994: Cox G M; Schell W A; Scher R L; Perfect J R
First report of involvement of Nodulisporium species in human disease.
Journal of clinical microbiology 1994;32(9):2301-4.
1994: Perfect J R; Wright K A
Amphotericin B lipid complex in the treatment of experimental cryptococcal meningitis and disseminated candidosis.
The Journal of antimicrobial chemotherapy 1994;33(1):73-81.
1993: Perfect J R; Ketabchi N; Cox G M; Ingram C W; Beiser C L
Karyotyping of Cryptococcus neoformans as an epidemiological tool.
Journal of clinical microbiology 1993;31(12):3305-9.
1993: Ingram C W; Haywood H B; Morris V M; Allen R L; Perfect J R
Cryptococcal ventricular-peritoneal shunt infection: clinical and epidemiological evaluation of two closely associated cases.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 1993;14(12):719-22.
1993: Cameron M L; Schell W A; Bruch S; Bartlett J A; Waskin H A; Perfect J R
Correlation of in vitro fluconazole resistance of Candida isolates in relation to therapy and symptoms of individuals seropositive for human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1993;37(11):2449-53.
1993: Perfect J R; Toffaletti D L; Rude T H
The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.
Infection and immunity 1993;61(10):4446-51.
1993: Perfect J R; Savani D V; Durack D T
Uptake of itraconazole by alveolar macrophages.
Antimicrobial agents and chemotherapy 1993;37(4):903-4.
1993: Toffaletti D L; Rude T H; Johnston S A; Durack D T; Perfect J R
Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA.
Journal of bacteriology 1993;175(5):1405-11.
1993: Perfect J R; Schell W A; Rinaldi M G
Uncommon invasive fungal pathogens in the acquired immunodeficiency syndrome.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1993;31(2):175-9.
1992: Perfect J R; Rude T H; Penning L M; Johnson S A
Cloning the Cryptococcus neoformans TRP1 gene by complementation in Saccharomyces cerevisiae.
Gene 1992;122(1):213-7.
1992: Perfect J R; Lindsay M H; Drew R H
Adverse drug reactions to systemic antifungals. Prevention and management.
Drug safety : an international journal of medical toxicology and drug experience 1992;7(5):323-63.
1992: Perfect J R; Klotman M E; Gilbert C C; Crawford D D; Rosner G L; Wright K A; Peters W P
Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients.
The Journal of infectious diseases 1992;165(5):891-7.
1992: Carlson A N; Foulks G N; Perfect J R; Kim J H
Fungal scleritis after cataract surgery. Successful outcome using itraconazole.
Cornea 1992;11(2):151-4.
1992: Goodwin S D; Fiedler-Kelly J; Grasela T H; Schell W A; Perfect J R
A nationwide survey of clinical laboratory methodologies for fungal infections.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology 1992;30(2):153-60.
1991: Perfect J R
Management of the immunocompromised patient: impact of fungal infections. Introduction.
Reviews of infectious diseases 1991;13(3):473.
1990: Wright K A; Perfect J R; Ritter W
The pharmacokinetics of BAY R3783 and its efficacy in the treatment of experimental cryptococcal meningitis.
The Journal of antimicrobial chemotherapy 1990;26(3):387-97.
1990: Hobbs M M; Perfect J R; Granger D L; Durack D T
Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis.
Infection and immunity 1990;58(7):2115-9.
1990: Perfect J R
Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit.
Reviews of infectious diseases 1990;12 Suppl 3():S299-302.
1990: Granger D L; Hibbs J B; Perfect J R; Durack D T
Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.
The Journal of clinical investigation 1990;85(1):264-73.
1989: Perfect J R; Hobbs M M; Wright K A; Durack D T
Treatment of experimental disseminated candidiasis with cilofungin.
Antimicrobial agents and chemotherapy 1989;33(10):1811-2.
1989: Perfect J R; Wright K A; Hobbs M M; Durack D T
Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304.
Antimicrobial agents and chemotherapy 1989;33(10):1735-40.
1989: Kim J H; Perfect J R
Infection and cyclosporine.
Reviews of infectious diseases 1989;11(5):677-90.
1989: Perfect J R; Magee B B; Magee P T
Separation of chromosomes of Cryptococcus neoformans by pulsed field gel electrophoresis.
Infection and immunity 1989;57(9):2624-7.
1989: Perfect J R
Cryptococcosis.
Infectious disease clinics of North America 1989;3(1):77-102.
1989: Herzog W; Perfect J; Roberts L
Intervertebral diskitis due to Candida tropicalis.
Southern medical journal 1989;82(2):270-3.
1988: Yadav S S; Perfect J; Friedman A H
Successful treatment of cryptococcal ventriculoatrial shunt infection with systemic therapy alone.
Neurosurgery 1988;23(3):372-3.
1988: Drew R H; Perfect J R; Gallis H A
Use of fluconazole in a patient with documented malabsorption of ketoconazole.
Clinical pharmacy 1988;7(8):622-3.
1988: Perfect J R; Hobbs M M; Granger D L; Durack D T
Cerebrospinal fluid macrophage response to experimental cryptococcal meningitis: relationship between in vivo and in vitro measurements of cytotoxicity.
Infection and immunity 1988;56(4):849-54.
1988: Granger D L; Hibbs J B; Perfect J R; Durack D T
Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.
The Journal of clinical investigation 1988;81(4):1129-36.
1987: Lallinger G J; Reiner S L; Cooke D W; Toffaletti D L; Perfect J R; Granger D L; Durack D T
Efficacy of immune therapy in early experimental Naegleria fowleri meningitis.
Infection and immunity 1987;55(5):1289-93.
1987: Savani D V; Perfect J R; Cobo L M; Durack D T
Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis.
Antimicrobial agents and chemotherapy 1987;31(1):6-10.
1986: Perfect J R; Savani D V; Durack D T
Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.
Antimicrobial agents and chemotherapy 1986;29(4):579-83.

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