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Muthu Periasamy

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Anuradha Kalyanasundaram; Björn C Knollmann; Veronique A LaCombe; Muthu Periasamy; Andriy Belevych; Lucia Brunello; Cynthia A Carnes; Paul M L Janssen; Sandor Gyørke
Up-regulation of sarcoplasmic reticulum Ca2+ uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.
Sanjaya K Sahoo; Sana A Shaikh; Danesh H Sopariwala; Naresh C Bal; Muthu Periasamy
Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump.
Steve R Roof; Lifei Tang; George E Billman; Sandor Györke; Joseph E Ostler; Muthu Periasamy; Mark T Ziolo
Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise.

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2013: Anuradha Kalyanasundaram; Björn C Knollmann; Veronique A LaCombe; Muthu Periasamy; Andriy Belevych; Lucia Brunello; Cynthia A Carnes; Paul M L Janssen; Sandor Gyørke
Up-regulation of sarcoplasmic reticulum Ca2+ uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.
Cardiovascular research 2013;98(2):297-306.
2013: Sanjaya K Sahoo; Sana A Shaikh; Danesh H Sopariwala; Naresh C Bal; Muthu Periasamy
Sarcolipin protein interaction with sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) is distinct from phospholamban protein, and only sarcolipin can promote uncoupling of the SERCA pump.
The Journal of biological chemistry 2013;288(10):6881-9.
2013: Steve R Roof; Lifei Tang; George E Billman; Sandor Györke; Joseph E Ostler; Muthu Periasamy; Mark T Ziolo
Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise.
Basic research in cardiology 2013;108(2):332.
2013: Qian Huang; Muthu Periasamy; Gopal J Babu; Thomas J Eddinger
SMB myosin heavy chain knockout enhances tonic contraction and reduces the rate of force generation in ileum and stomach antrum.
American journal of physiology. Cell physiology 2013;304(2):C194-206.
2013: Amanda P Waller; Muthu Periasamy; Michael George; Keli Hu; Anuradha Kalyanasundaram; Chen Kang; Veronique A LaCombe
GLUT12 functions as a basal and insulin-independent glucose transporter in the heart.
Biochimica et biophysica acta 2013;1832(1):121-7.
2012: Naresh C Bal; Sanjeewa A Goonasekera; Subash C Gupta; Santosh K Maurya; Jeffery D Molkentin; Meghna Pant; Leslie A Rowland; Sanjaya K Sahoo; Sana A Shaikh; Danesh H Sopariwala; Eric Bombardier; A Russell Tupling; Muthu Periasamy
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.
Nature medicine 2012;18(10):1575-9.
2012: Fangping Yang; Rumana Yasmeen; Xulang Zhang; Gregg Duester; K Valerie Bergdall; David DiSilvestro; L James Lee; Andrei Maiseyeu; Santosh K Maurya; Georgeta Mihai; Muthu Periasamy; Sanjay Rajagopalan; Sashwati Roy; Chandan K Sen; Ouliana Ziouzenkova
The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine.
Biomaterials 2012;33(22):5638-49.
2012: Lai-Hua Xie; Zhenghang Zhao; Ji Yeon Park; Muthu Periasamy; Mayilvahanan Shanmugam; Bin Tian; Hairuo Wen; Gopal J Babu
Ablation of sarcolipin results in atrial remodeling.
American journal of physiology. Cell physiology 2012;302(12):C1762-71.
2012: Nadine Bakkar; Naresh C Bal; Benjamin D Canan; Paul Janssen; Katherine J Ladner; Qiutang Li; Sandya Liyanarachchi; Meghna Pant; Muthu Periasamy; Denis C Guttridge
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
The Journal of cell biology 2012;196(4):497-511.
2011: A Russell Tupling; Chris Vigna; Gopal J Babu; Peter H Backx; Darin Bloemberg; Eric Bombardier; Subash C Gupta; Dawar Hussain; David H MacLennan; Muthu Periasamy; Joe Quadrilatero; Maria G Trivieri; Anthony O Gramolini
Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.
American journal of physiology. Cell physiology 2011;301(4):C841-9.
2011: Naresh C Bal; Tuniki Balaraju; Sandor Gyorke; Nivedita Jena; Sana Shaikh; Ashoke Sharon; Danesh Sopariwala; Chandralata Bal; Muthu Periasamy
Probing cationic selectivity of cardiac calsequestrin and its CPVT mutants.
The Biochemical journal 2011;435(2):391-9.
2011: Chun Hong Shao; Haley L Capek; Kaushik P Patel; Mu Wang; Kang Tang; Cyrus DeSouza; Ryoji Nagai; William Mayhan; Muthu Periasamy; Keshore R Bidasee
Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes.
Diabetes 2011;60(3):947-59.
2011: M A Hassan Talukder; Fuchun Yang; Yoshinori Nishijima; Chun-An Chen; Lin Xie; Shouvik D Mahamud; Anuradha Kalyanasundaram; John D Bonagura; Muthu Periasamy; Jay L Zweier
Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology 2011;300(2):H702-11.
2011: Mayilvahanan Shanmugam; Shumin Gao; Chull Hong; Nadezhda Fefelova; Martha C Nowycky; Lai-Hua Xie; Muthu Periasamy; Gopal J Babu
Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility.
Cardiovascular research 2011;89(2):353-61.
2011: Mei Chi; Danesh Sopariwala; Yingbi Zhou; Muthu Periasamy
SM2(+/-) male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 2011;47(3-4):67-78.
2010: Naresh C Bal; Ashoke Sharon; Subash C Gupta; Nivedita Jena; Sana Shaikh; Sandor Gyorke; Muthu Periasamy
The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization.
The Journal of biological chemistry 2010;285(22):17188-96.
2010: Brenda J Lilly; Kathleen A Clark; Masaaki Yoshigi; Stephen Pronovost; Meng-Ling Wu; Muthu Periasamy; Mei Chi; Richard J Paul; Shaw-Fang Yet; Mary C Beckerle
Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):694-701.
2010: Anuradha Kalyanasundaram; Naresh C Bal; Clara Franzini-Armstrong; Björn C Knollmann; Muthu Periasamy
The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering.
The Journal of biological chemistry 2010;285(5):3076-83.
2009: M A Hassan Talukder; Jay L Zweier; Muthu Periasamy
Targeting calcium transport in ischaemic heart disease.
Cardiovascular research 2009;84(3):345-52.
2009: Poornima Bhupathy; Gopal J Babu; Makoto Ito; Muthu Periasamy
Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes.
Journal of molecular and cellular cardiology 2009;47(5):723-9.
2009: Sarah CW Stevens; Dmitry Terentyev; Anuradha Kalyanasundaram; Muthu Periasamy; Sandor Györke
Intra-sarcoplasmic reticulum Ca2+ oscillations are driven by dynamic regulation of ryanodine receptor function by luminal Ca2+ in cardiomyocytes.
The Journal of physiology 2009;587(Pt 20):4863-72.
2009: Kenneth D Varian; Anusak kijtawornrat; Subash C Gupta; Carlos A A Torres; Michelle M Monasky; Nitisha Hiranandani; Dawn A Delfin; Jill A Rafael-Fortney; Muthu Periasamy; Robert L Hamlin; Paul Janssen
Impairment of diastolic function by lack of frequency-dependent myofilament desensitization rabbit right ventricular hypertrophy.
Circulation. Heart failure 2009;2(5):472-81.
2009: Subash C Gupta; Kenneth D Varian; Naresh C Bal; Jessica L Abraham; Muthu Periasamy; Paul Janssen
Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits.
American journal of physiology. Heart and circulatory physiology 2009;296(6):H1933-9.
2009: Muthu Periasamy; Jill A Rafael-Fortney
Somatic gene therapy to treat heart failure is one step closer to reality.
Cardiovascular research 2009;82(3):383-4.
2009: Ning Li; Valeriy Timofeyev; Dipika Tuteja; Danyan Xu; Ling Lu; Qian Zhang; Zhao Zhang; Anil Singapuri; Trevine R Albert; Amutha V Rajagopal; Chris T Bond; Muthu Periasamy; John P Adelman; Nipavan Chiamvimonvat
Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation.
The Journal of physiology 2009;587(Pt 5):1087-100.
2009: Joseph A Hypolite; Shaohua Chang; Edward LaBelle; Gopal J Babu; Muthu Periasamy; Alan J Wein; Samuel Chacko
Deletion of SM-B, the high ATPase isoform of myosin, upregulates the PKC-mediated signal transduction pathway in murine urinary bladder smooth muscle.
American journal of physiology. Renal physiology 2009;296(3):F658-65.
2009: M A Hassan Talukder; Fuchun Yang; Yoshinori Nishijima; Chun-An Chen; Anuradha Kalyanasundaram; Muthu Periasamy; Jay L Zweier
Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery.
Journal of molecular and cellular cardiology 2009;46(2):285-7.
2008: Mei Chi; Yingbi Zhou; Srikanth Vedamoorthyrao; Gopal J Babu; Muthu Periasamy
Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18614-8.
2008: Coen A C Ottenheijm; Chi Fong; Peter Vangheluwe; Frank Wuytack; Gopal J Babu; Muthu Periasamy; Christian C Witt; Siegfried Labeit; Henk Granzier
Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2912-9.
2008: Muthu Periasamy; Anuradha Kalyanasundaram
SERCA2a gene therapy for heart failure: ready for primetime?
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1002-4.
2008: M A Hassan Talukder; Anuradha Kalyanasundaram; Li Zuo; Murugesan Velayutham; Yoshinori Nishijima; Muthu Periasamy; Jay L Zweier
Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1426-34.
2008: Muthu Periasamy; Poornima Bhupathy; Gopal J Babu
Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology.
Cardiovascular research 2008;77(2):265-73.
2008: Muthu Periasamy; Paul Janssen
Molecular basis of diastolic dysfunction.
Heart failure clinics 2008;4(1):13-21.
2007: Gopal J Babu; Poornima Bhupathy; Valeriy Timofeyev; Natalia N Petrashevskaya; Peter J Reiser; Nipavan Chiamvimonvat; Muthu Periasamy
Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17867-72.
2007: Paul Janssen; Muthu Periasamy
Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.
Journal of molecular and cellular cardiology 2007;43(5):523-31.
2007: M A Hassan Talukder; Anuradha Kalyanasundaram; Xue Zhao; Li Zuo; Poornima Bhupathy; Gopal J Babu; Arturo J Cardounel; Muthu Periasamy; Jay L Zweier
Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2418-28.
2007: Halvor K Mørk; Ivar Sjaastad; Jørn B Sande; Muthu Periasamy; Ole M Sejersted; William E Louch
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
Journal of molecular and cellular cardiology 2007;43(2):177-86.
2007: Gopal J Babu; Poornima Bhupathy; Cynthia A Carnes; George E Billman; Muthu Periasamy
Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology.
Journal of molecular and cellular cardiology 2007;43(2):215-22.
2007: Wessel P Dirksen; Veronique A LaCombe; Mei Chi; Anuradha Kalyanasundaram; Serge Viatchenko-Karpinski; Dmitry Terentyev; Zhixiang Zhou; Srikanth Vedamoorthyrao; Ning Li; Nipavan Chiamvimonvat; Cynthia A Carnes; Clara Franzini-Armstrong; Sandor Györke; Muthu Periasamy
A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice.
Cardiovascular research 2007;75(1):69-78.
2007: Nitisha Hiranandani; Sripriya Raman; Anuradha Kalyanasundaram; Muthu Periasamy; Paul Janssen
Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(1):R30-6.
2007: Srinivas Iyengar; Garrie Haas; Sumant Lamba; David A Orsinelli; Gopal J Babu; Amy K Ferketich; Laura Yamokoski; Muthu Periasamy; William T Abraham
Effect of cardiac resynchronization therapy on myocardial gene expression in patients with nonischemic dilated cardiomyopathy.
Journal of cardiac failure 2007;13(4):304-11.
2007: Poornima Bhupathy; Gopal J Babu; Muthu Periasamy
Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase.
Journal of molecular and cellular cardiology 2007;42(5):903-11.
2007: Muthu Periasamy; Anuradha Kalyanasundaram
SERCA pump isoforms: their role in calcium transport and disease.
Muscle & nerve 2007;35(4):430-42.
2006: Gopal J Babu; Gerard Celia; Albert Rhee; Hisako Yamamura; Katsuhito Takahashi; Frank V Brozovich; George Osol; Muthu Periasamy
Effects of h1-calponin ablation on the contractile properties of bladder versus vascular smooth muscle in mice lacking SM-B myosin.
The Journal of physiology 2006;577(Pt 3):1033-42.
2006: Gopal J Babu; Poornima Bhupathy; Natalia N Petrashevskaya; Honglan Wang; Sripriya Raman; Debra Wheeler; Ganapathy Jagatheesan; David F Wieczorek; Arnold Schwartz; Paul Janssen; Mark T Ziolo; Muthu Periasamy
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.
The Journal of biological chemistry 2006;281(7):3972-9.
2005: Marta Rubio; Ilona Bodi; Geraldine A Fuller-Bicer; Harvey S Hahn; Muthu Periasamy; Arnold Schwartz
Sarcoplasmic reticulum adenosine triphosphatase overexpression in the L-type Ca2+ channel mouse results in cardiomyopathy and Ca2+ -induced arrhythmogenesis.
Journal of cardiovascular pharmacology and therapeutics 2005;10(4):235-49.
2005: Andreas Patzak; Daria Petzhold; Thomas Wronski; Peter Martinka; Gopal J Babu; Muthu Periasamy; Hannelore Haase; Ingo Morano
Constriction velocities of renal afferent and efferent arterioles of mice are not related to SMB expression.
Kidney international 2005;68(6):2726-34.
2005: Muthu Periasamy
Obituary for Norman Alpert (1922-2004).
Journal of molecular and cellular cardiology 2005;38(4):701-2.
2005: Yingbi Zhou; Wessel P Dirksen; Yanfang Chen; Mariana Morris; Jay L Zweier; Muthu Periasamy
A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues.
Journal of molecular and cellular cardiology 2005;38(4):693-6.
2005: Norimichi Koitabashi; Masashi Arai; Koichi Tomaru; Takako Takizawa; Atai Watanabe; Kazuo Niwano; Tomoyuki Yokoyama; Frank Wuytack; Muthu Periasamy; Ryozo Nagai; Masahiko Kurabayashi
Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 binding.
Biochemical and biophysical research communications 2005;328(1):116-24.
2005: Yanfang Xu; Zhao Zhang; Valeriy Timofeyev; Dipika Sharma; Danyan Xu; Dipika Tuteja; Pei Hong Dong; Gias Ahmmed; Yong Ji; Gary E Shull; Muthu Periasamy; Nipavan Chiamvimonvat
The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice.
The Journal of physiology 2005;562(Pt 3):745-58.
2005: Gopal J Babu; Muthu Periasamy
Transgenic mouse models for cardiac dysfunction by a specific gene manipulation.
Methods in molecular medicine 2005;112():365-77.
2005: Gopal J Babu; Zhaolun Zheng; Poornima Natarajan; Debra Wheeler; Paul Janssen; Muthu Periasamy
Overexpression of sarcolipin decreases myocyte contractility and calcium transient.
Cardiovascular research 2005;65(1):177-86.
2004: Sabine Huke; Muthu Periasamy
Phosphorylation-status of phospholamban and calsequestrin modifies their affinity towards commonly used antibodies.
Journal of molecular and cellular cardiology 2004;37(3):795-9.
2004: Gopal J Babu; Gail J Pyne; Yingbi Zhou; Chris Okwuchukuasanya; Joseph E Brayden; George Osol; Richard J Paul; Robert B Low; Muthu Periasamy
Isoform switching from SM-B to SM-A myosin results in decreased contractility and altered expression of thin filament regulatory proteins.
American journal of physiology. Cell physiology 2004;287(3):C723-9.
2004: Yingbi Zhou; Wessel P Dirksen; Jay L Zweier; Muthu Periasamy
Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types.
American journal of physiology. Heart and circulatory physiology 2004;287(2):H573-8.
2004: Ashour Michael; Syed Haq; Xin Chen; Eileen Hsich; Lei Cui; Brian Walters; Zhili Shao; Kausik Bhattacharya; Heiko Kilter; Gordon S Huggins; Michele Andreucci; Muthu Periasamy; Robert N Solomon; Ronglih Liao; Richard D Patten; Jeffery D Molkentin; Thomas Force
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
The Journal of biological chemistry 2004;279(20):21383-93.
2004: Jo El J Schultz; Betty J Glascock; Sandra A Witt; Michelle L Nieman; Kalpana J Nattamai; Lynne H Liu; John N Lorenz; Gary E Shull; Thomas R Kimball; Muthu Periasamy
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.
American journal of physiology. Heart and circulatory physiology 2004;286(3):H1146-53.
2004: Stephanie Tuck; Karim Maghni; Annie Poirier; Gopal J Babu; Muthu Periasamy; Jason H T Bates; Renaud Leguillette; Anne-Marie Lauzon
Time course of airway mechanics of the (+)insert myosin isoform knockout mouse.
American journal of respiratory cell and molecular biology 2004;30(3):326-32.
2004: Gopal J Babu; Debra Wheeler; Oscar Alzate; Muthu Periasamy
Solubilization of membrane proteins for two-dimensional gel electrophoresis: identification of sarcoplasmic reticulum membrane proteins.
Analytical biochemistry 2004;325(1):121-5.
2004: Peter Karagiannis; Gopal J Babu; Muthu Periasamy; Frank V Brozovich
Myosin heavy chain isoform expression regulates shortening velocity in smooth muscle: studies using an SMB KO mouse line.
Journal of muscle research and cell motility 2004;25(2):149-58.
2003: Yingbi Zhou; Wessel P Dirksen; Gopal J Babu; Muthu Periasamy
Differential vasoconstrictions induced by angiotensin II: role of AT1 and AT2 receptors in isolated C57BL/6J mouse blood vessels.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2797-803.
2003: Yingbi Zhou; Yanfang Chen; Wessel P Dirksen; Mariana Morris; Muthu Periasamy
AT1b receptor predominantly mediates contractions in major mouse blood vessels.
Circulation research 2003;93(11):1089-94.
2003: Sabine Huke; Lynne H Liu; Danuta Biniakiewicz; William T Abraham; Muthu Periasamy
Altered force-frequency response in non-failing hearts with decreased SERCA pump-level.
Cardiovascular research 2003;59(3):668-77.
2003: Takako Takizawa; Masashi Arai; Koichi Tomaru; Norimichi Koitabashi; Debra L Baker; Muthu Periasamy; Masahiko Kurabayashi
Transcription factor Sp1 regulates SERCA2 gene expression in pressure-overloaded hearts: a study using in vivo direct gene transfer into living myocardium.
Journal of molecular and cellular cardiology 2003;35(7):777-83.
2003: David M Plank; Atsuko Yatani; Honda Ritsu; Sandra Witt; Betty J Glascock; M Jane Lalli; Muthu Periasamy; Celine Fiset; Nancy A Benkusky; Héctor H Valdivia; Mark A Sussman
Calcium dynamics in the failing heart: restoration by beta-adrenergic receptor blockade.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H305-15.
2003: Gary E Shull; Gbolahan Okunade; Lynne H Liu; Peter J Kozel; Muthu Periasamy; John N Lorenz; Vikram Prasad
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants.
Annals of the New York Academy of Sciences 2003;986():453-60.
2003: Peter Karagiannis; Gopal J Babu; Muthu Periasamy; Frank V Brozovich
The smooth muscle myosin seven amino acid heavy chain insert's kinetic role in the crossbridge cycle for mouse bladder.
The Journal of physiology 2003;547(Pt 2):463-73.
2003: Wen Zhao; Konrad Frank; Guoxiang Chu; Michael J Gerst; Albrecht G Schmidt; Yong Ji; Muthu Periasamy; Evangelia G Kranias
Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state.
Cardiovascular research 2003;57(1):71-81.
2002: Sabine Huke; Vikram Prasad; Michelle L Nieman; Kalpana J Nattamai; Ingrid L Grupp; John N Lorenz; Muthu Periasamy
Altered dose response to beta-agonists in SERCA1a-expressing hearts ex vivo and in vivo.
American journal of physiology. Heart and circulatory physiology 2002;283(3):H958-65.
2002: Muthu Periasamy
Calcineurin and the heartbeat, an evolving story.
Journal of molecular and cellular cardiology 2002;34(3):259-62.
2001: Gopal J Babu; EV Loukianov; T Loukianova; Gail J Pyne; Sabine Huke; George Osol; R B Low; Richard J Paul; Muthu Periasamy
Loss of SM-B myosin affects muscle shortening velocity and maximal force development.
Nature cell biology 2001;3(11):1025-9.
2001: Mark Ver Heyen; Stephane Heymans; Gudrun Antoons; T Reed; Muthu Periasamy; Bonaventure L Awede; Jean Lebacq; Peter Vangheluwe; Mieke Dewerchin; Désiré Collen; Karin R Sipido; Peter Carmeliet; Frank Wuytack
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Circulation research 2001;89(9):838-46.
2001: M Jane Lalli; J Yong; V Prasad; K Hashimoto; David M Plank; Gopal J Babu; DL Kirkpatrick; Richard A Walsh; Mark Sussman; Atsuko Yatani; Eduardo Marban; Muthu Periasamy
Sarcoplasmic reticulum Ca(2+) atpase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca(2+) handling capacity.
Circulation research 2001;89(2):160-7.
2001: Lynne H Liu; Gregory P Boivin; Vikram Prasad; Muthu Periasamy; Gary E Shull
Squamous cell tumors in mice heterozygous for a null allele of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca2+ pump.
The Journal of biological chemistry 2001;276(29):26737-40.
2001: Muthu Periasamy; Sabine Huke
SERCA pump level is a critical determinant of Ca(2+)homeostasis and cardiac contractility.
Journal of molecular and cellular cardiology 2001;33(6):1053-63.
2000: Yong Ji; M Jane Lalli; Gopal J Babu; Y Xu; DL Kirkpatrick; Lynne H Liu; Nipavan Chiamvimonvat; Richard A Walsh; Gary E Shull; Muthu Periasamy
Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.
The Journal of biological chemistry 2000;275(48):38073-80.
2000: Gopal J Babu; D M Warshaw; Muthu Periasamy
Smooth muscle myosin heavy chain isoforms and their role in muscle physiology.
Microscopy research and technique 2000;50(6):532-40.
2000: A L Greene; M Jane Lalli; Yong Ji; Gopal J Babu; Ingrid L Grupp; Mark Sussman; Muthu Periasamy
Overexpression of SERCA2b in the heart leads to an increase in sarcoplasmic reticulum calcium transport function and increased cardiac contractility.
The Journal of biological chemistry 2000;275(32):24722-7.
2000: Gopal J Babu; M Jane Lalli; Mark A Sussman; J Sadoshima; Muthu Periasamy
Phosphorylation of elk-1 by MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy.
Journal of molecular and cellular cardiology 2000;32(8):1447-57.
2000: Thomas D Reed; Gopal J Babu; Yong Ji; A Zilberman; Mark Ver Heyen; Frank Wuytack; Muthu Periasamy
The expression of SR calcium transport ATPase and the Na(+)/Ca(2+)Exchanger are antithetically regulated during mouse cardiac development and in Hypo/hyperthyroidism.
Journal of molecular and cellular cardiology 2000;32(3):453-64.
2000: Mark Ver Heyen; Thomas D Reed; R I Blough; D L Baker; A Zilberman; EV Loukianov; Kurt Van Baelen; Luc Raeymaekers; Muthu Periasamy; Frank Wuytack
Structure and organization of the mouse Atp2a2 gene encoding the sarco(endo)plasmic reticulum Ca2+-ATPase 2 (SERCA2) isoforms.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(2):159-63.
1999: Yong Ji; EV Loukianov; Muthu Periasamy
Analysis of sarcoplasmic reticulum Ca2+ transport and Ca2+ ATPase enzymatic properties using mouse cardiac tissue homogenates.
Analytical biochemistry 1999;269(2):236-44.
1999: Muthu Periasamy; Thomas D Reed; Lynne H Liu; Yong Ji; EV Loukianov; Richard J Paul; Michelle L Nieman; Tara M Riddle; JJ Duffy; Thomas Doetschman; John N Lorenz; Gary E Shull
Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene.
The Journal of biological chemistry 1999;274(4):2556-62.
1999: Yong Ji; EV Loukianov; T Loukianova; L R Jones; Muthu Periasamy
SERCA1a can functionally substitute for SERCA2a in the heart.
The American journal of physiology 1999;276(1 Pt 2):H89-97.
1999: Y Takeishi; A Bhagwat; NA Ball; D L Kirkpatrick; Muthu Periasamy; Richard A Walsh
Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure.
The American journal of physiology 1999;276(1 Pt 2):H53-62.
1998: DL Baker; K Hashimoto; Ingrid L Grupp; Yong Ji; T Reed; EV Loukianov; G Grupp; A Bhagwhat; Brian D Hoit; R Walsh; Eduardo Marban; Muthu Periasamy
Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts.
Circulation research 1998;83(12):1205-14.
1998: EV Loukianov; Yong Ji; Ingrid L Grupp; DL Kirkpatrick; DL Baker; T Loukianova; G Grupp; J Lytton; Richard A Walsh; Muthu Periasamy
Enhanced myocardial contractility and increased Ca2+ transport function in transgenic hearts expressing the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase.
Circulation research 1998;83(9):889-97.
1998: EV Loukianov; Yong Ji; DL Baker; T Reed; J Babu; T Loukianova; A Greene; Gary E Shull; Muthu Periasamy
Sarco(endo)plasmic reticulum Ca2+ ATPase isoforms and their role in muscle physiology and pathology.
Annals of the New York Academy of Sciences 1998;853():251-9.
1998: A Zilberman; Vrushank Dave; J Miano; E N Olson; Muthu Periasamy
Evolutionarily conserved promoter region containing CArG*-like elements is crucial for smooth muscle myosin heavy chain gene expression.
Circulation research 1998;82(5):566-75.
1998: D L Baker; Vrushank Dave; T Reed; S Misra; Muthu Periasamy
A novel E box/AT-rich element is required for muscle-specific expression of the sarcoplasmic reticulum Ca2+-ATPase (SERCA2) gene.
Nucleic acids research 1998;26(4):1092-8.
1998: Y Katoh; Jeffery D Molkentin; Vrushank Dave; E N Olson; Muthu Periasamy
MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression.
The Journal of biological chemistry 1998;273(3):1511-8.
1997: EV Loukianov; T Loukianova; Muthu Periasamy
Identification of targeted embryonic stem cells using long-distance PCR.
BioTechniques 1997;23(3):376-8, 380.
1997: EV Loukianov; T Loukianova; Muthu Periasamy
Efficient cloning method that selects the recombinant clones.
BioTechniques 1997;23(2):292-5.
1997: EV Loukianov; T Loukianova; Muthu Periasamy
Myosin heavy chain isoforms in smooth muscle.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997;117(1):13-8.
1997: EV Loukianov; T Loukianova; Muthu Periasamy
Cloning DNA fragments between two adjacent/overlapping restriction sites using a "positive stuffer".
BioTechniques 1997;22(5):912-5.
1996: S F Khoury; Brian D Hoit; Vrushank Dave; CM Pawloski-Dahm; Y Shao; M Gabel; Muthu Periasamy; R A Walsh
Effects of thyroid hormone on left ventricular performance and regulation of contractile and Ca(2+)-cycling proteins in the baboon. Implications for the force-frequency and relaxation-frequency relationships.
Circulation research 1996;79(4):727-35.
1996: D L Baker; Vrushank Dave; T Reed; Muthu Periasamy
Multiple Sp1 binding sites in the cardiac/slow twitch muscle sarcoplasmic reticulum Ca2+-ATPase gene promoter are required for expression in Sol8 muscle cells.
The Journal of biological chemistry 1996;271(10):5921-8.
1995: H Matsui; David H MacLennan; Norman R Alpert; Muthu Periasamy
Sarcoplasmic reticulum gene expression in pressure overload-induced cardiac hypertrophy in rabbit.
The American journal of physiology 1995;268(1 Pt 1):C252-8.
1994: Y Katoh; EV Loukianov; Elizabeth Kopras; A Zilberman; Muthu Periasamy
Identification of functional promoter elements in the rabbit smooth muscle myosin heavy chain gene.
The Journal of biological chemistry 1994;269(48):30538-45.
1994: Steven Fisher; Muthu Periasamy
Collagen synthesis inhibitors disrupt embryonic cardiocyte myofibrillogenesis and alter the expression of cardiac specific genes in vitro.
Journal of molecular and cellular cardiology 1994;26(6):721-31.
1994: M Arai; H Matsui; Muthu Periasamy
Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.
Circulation research 1994;74(4):555-64.
1994: A Zarain-Herzberg; J Marques; D Sukovich; Muthu Periasamy
Thyroid hormone receptor modulates the expression of the rabbit cardiac sarco (endo) plasmic reticulum Ca(2+)-ATPase gene.
The Journal of biological chemistry 1994;269(2):1460-7.
1993: M Aikawa; Nallasivam Palanisamy; Makoto Kuro-o; K Kimura; K Nakahara; S Takewaki; M Ueda; H Yamaguchi; Y Yazaki; Muthu Periasamy
Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.
Circulation research 1993;73(6):1000-12.
1993: Steven Fisher; P M Buttrick; D Sukovich; Muthu Periasamy
Characterization of promoter elements of the rabbit cardiac sarcoplasmic reticulum Ca(2+)-ATPase gene required for expression in cardiac muscle cells.
Circulation research 1993;73(4):622-8.
1993: K Otsu; J Fujii; Muthu Periasamy; M Difilippantonio; M Uppender; D C Ward; David H MacLennan
Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.
Genomics 1993;17(2):507-9.
1993: P Babij; J Zhao; S White; J Woodcock-Mitchell; J Mitchell; M Absher; Linda C Baldor; Muthu Periasamy; Robert Low
Smooth muscle myosin regulation by serum and cell density in cultured rat lung connective tissue cells.
The American journal of physiology 1993;265(2 Pt 1):L127-32.
1993: D A Sukovich; J Shabbeer; Muthu Periasamy
Analysis of the rabbit cardiac/slow twitch muscle sarcoplasmic reticulum calcium ATPase (SERCA2) gene promoter.
Nucleic acids research 1993;21(11):2723-8.
1993: J Woodcock-Mitchell; S White; W Stirewalt; Muthu Periasamy; J Mitchell; Robert Low
Myosin isoform expression in developing and remodeling rat lung.
American journal of respiratory cell and molecular biology 1993;8(6):617-25.
1993: O Saitoh; A Fujisawa-Sehara; Yo-ichi Nabeshima; Muthu Periasamy
Expression of myogenic factors in denervated chicken breast muscle: isolation of the chicken Myf5 gene.
Nucleic acids research 1993;21(10):2503-9.
1993: S White; Anne F Martin; Muthu Periasamy
Identification of a novel smooth muscle myosin heavy chain cDNA: isoform diversity in the S1 head region.
The American journal of physiology 1993;264(5 Pt 1):C1252-8.
1993: M Arai; Norman R Alpert; David H MacLennan; P Barton; Muthu Periasamy
Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.
Circulation research 1993;72(2):463-9.
1992: O Saitoh; Muthu Periasamy; M Kan; R Matsuda
cis-4-Hydroxy-L-proline and ethyl-3,4-dihydroxybenzoate prevent myogenesis of C2C12 muscle cells and block MyoD1 and myogenin expression.
Experimental cell research 1992;200(1):70-6.
1992: D E Harris; David M Warshaw; Muthu Periasamy
Nucleotide sequences of the rabbit alpha-smooth-muscle and beta-non-muscle actin mRNAs.
Gene 1992;112(2):265-6.
1992: P Babij; S Kawamoto; S White; R S Adelstein; Muthu Periasamy
Differential expression of SM1 and SM2 myosin isoforms in cultured vascular smooth muscle.
The American journal of physiology 1992;262(3 Pt 1):C607-13.
1992: M Arai; K Otsu; David H MacLennan; Muthu Periasamy
Regulation of sarcoplasmic reticulum gene expression during cardiac and skeletal muscle development.
The American journal of physiology 1992;262(3 Pt 1):C614-20.
1991: M Arai; Norman R Alpert; Muthu Periasamy
Cloning and characterization of the gene encoding rabbit cardiac calsequestrin.
Gene 1991;109(2):275-9.
1991: S Shull; Nicholas H Heintz; Muthu Periasamy; M Manohar; YM Janssen; J P Marsh; Brooke T Mossman
Differential regulation of antioxidant enzymes in response to oxidants.
The Journal of biological chemistry 1991;266(36):24398-403.
1991: P Babij; C Kelly; Muthu Periasamy
Characterization of a mammalian smooth muscle myosin heavy-chain gene: complete nucleotide and protein coding sequence and analysis of the 5' end of the gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10676-80.
1991: M Arai; K Otsu; David H MacLennan; Norman R Alpert; Muthu Periasamy
Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins.
Circulation research 1991;69(2):266-76.
1990: A Zarain-Herzberg; David H MacLennan; Muthu Periasamy
Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene.
The Journal of biological chemistry 1990;265(8):4670-7.
1989: P Babij; Muthu Periasamy
Myosin heavy chain isoform diversity in smooth muscle is produced by differential RNA processing.
Journal of molecular biology 1989;210(3):673-9.
1989: Muthu Periasamy; R Wadgaonkar; C Kumar; B J Martin; M A Siddiqui
Characterization of a rat myosin alkali light chain gene expressed in ventricular and slow twitch skeletal muscles.
Nucleic acids research 1989;17(19):7723-34.
1989: R Nagai; Makoto Kuro-o; P Babij; Muthu Periasamy
Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis.
The Journal of biological chemistry 1989;264(17):9734-7.
1989: Jonathan Lytton; A Zarain-Herzberg; Muthu Periasamy; David H MacLennan
Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase.
The Journal of biological chemistry 1989;264(12):7059-65.
1989: R Nagai; A Zarain-Herzberg; C J Brandl; J Fujii; M Tada; David H MacLennan; N R Alpert; Muthu Periasamy
Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2966-70.
1988: R Nagai; D M Larson; Muthu Periasamy
Characterization of a mammalian smooth muscle myosin heavy chain cDNA clone and its expression in various smooth muscle types.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(4):1047-51.