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Olga Perisic

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

X Ray Crystallography

Chemicals & Drugs

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Physiology

Protein Transport

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Endosomes

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Publications

TOP 3
John E Burke; Olga Perisic; Roger L Williams
Allosteric activation of PI3Kα by oncogenic mutations.
Hashem Dbouk; T Kendall Harden; Christian Harteneck; Christine Hsueh; Bassem D Khalil; Bernd Nürnberg; Olga Perisic; Rachel S Salamon; Peter R Shepherd; Aliaksei Shymanets; Alan V Smrcka; Chinmay Surve; Ronald Taussig; Oscar Vadas; Gary L Waldo; Roger L Williams; Mathew O Barrett; Anne R Bresnick; John E Burke; Jonathan M Backer
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.
Michael A Hadders; Magdalena Kloc; Meindert H Lamers; Monica Agromayor; Anna Caballe; Takayuki Obita; Olga Perisic; Roger L Williams; Juan Martin-Serrano
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.

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All Publications

2013: John E Burke; Olga Perisic; Roger L Williams
Allosteric activation of PI3Kα by oncogenic mutations.
Oncotarget 2013;4(2):180-1.
2012: Hashem Dbouk; T Kendall Harden; Christian Harteneck; Christine Hsueh; Bassem D Khalil; Bernd Nürnberg; Olga Perisic; Rachel S Salamon; Peter R Shepherd; Aliaksei Shymanets; Alan V Smrcka; Chinmay Surve; Ronald Taussig; Oscar Vadas; Gary L Waldo; Roger L Williams; Mathew O Barrett; Anne R Bresnick; John E Burke; Jonathan M Backer
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.
Science signaling 2012;5(253):ra89.
2012: Michael A Hadders; Magdalena Kloc; Meindert H Lamers; Monica Agromayor; Anna Caballe; Takayuki Obita; Olga Perisic; Roger L Williams; Juan Martin-Serrano
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17424-9.
2012: John E Burke; Glenn R Masson; Olga Perisic; Oscar Vadas; Roger L Williams
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15259-64.
2011: John E Burke; Tara Finegan; Olga Perisic; Oscar Vadas; Alex Berndt; Roger L Williams
Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.
Structure (London, England : 1993) 2011;19(8):1127-37.
2011: Xuxiao Zhang; Oscar Vadas; Olga Perisic; Karen E Anderson; Jonathan Clark; Phillip T Hawkins; Len R Stephens; Roger L Williams
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Molecular cell 2011;41(5):567-78.
2010: Simon Miller; Arkadiusz Oleksy; Olga Perisic; Roger L Williams
Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.
Autophagy 2010;6(6):805-7.
2010: Simon Miller; Brandon Tavshanjian; Arkadiusz Oleksy; Olga Perisic; Benjamin T Houseman; Kevan M Shokat; Roger L Williams
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.
Science (New York, N.Y.) 2010;327(5973):1638-42.
2009: Sara Ghazi-Tabatabai; Takayuki Obita; Ajaybabu V Pobbati; Olga Perisic; Rachel Y Samson; Stephen D Bell; Roger L Williams
Evolution and assembly of ESCRTs.
Biochemical Society transactions 2009;37(Pt 1):151-5.
2007: Takayuki Obita; Suraj Saksena; Sara Ghazi-Tabatabai; David J Gill; Olga Perisic; Scott D Emr; Roger L Williams
Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.
Nature 2007;449(7163):735-9.
2007: Laboratoire Biochimie et Genie Enzymatique des Lipases; Ying Yan; Wai-Ching Hon; Olga Perisic; Marketa Zvelebil; Yuval Inbar; Dina Schneidman-Duhovny; Haim Wolfson; Jonathan M Backer; Roger L Williams
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
Science (New York, N.Y.) 2007;317(5835):239-42.
2007: David J Gill; Hsiangling Teo; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Scott D Emr; Roger L Williams
Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.
The EMBO journal 2007;26(2):600-12.
2007: David J Gill; Hsiangling Teo; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Yvonne Vallis; Scott D Emr; Roger L Williams
Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.
Biochemical Society symposium 2007;(74):47-57.
2006: Hsiangling Teo; David J Gill; Ji Sun; Olga Perisic; Dmitry B Veprintsev; Yvonne Vallis; Scott D Emr; Roger L Williams
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.
Cell 2006;125(1):99-111.
2005: Daniela Stock; Olga Perisic; Jan Löwe
Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology.
Progress in biophysics and molecular biology 2005;88(3):311-27.
2004: Hsiangling Teo; Olga Perisic; Beatriz González; Roger L Williams
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.
Developmental cell 2004;7(4):559-69.
2004: Olga Perisic; Michael I Wilson; Dimitrios Karathanassis; Jerónimo Bravo; Michael E Pacold; Chris D Ellson; Phillip T Hawkins; Len Stephens; Roger L Williams
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.
Advances in enzyme regulation 2004;44():279-98.
2003: Bojana Panic; Olga Perisic; Dmitry B Veprintsev; Roger L Williams; Sean Munro
Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.
Molecular cell 2003;12(4):863-74.
2003: Michael I Wilson; David J Gill; Olga Perisic; Mark T Quinn; Roger L Williams
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.
Molecular cell 2003;12(1):39-50.
2002: Dimitrios Karathanassis; Robert V Stahelin; Jerónimo Bravo; Olga Perisic; Christine M Pacold; Wonhwa Cho; Roger L Williams
Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction.
The EMBO journal 2002;21(19):5057-68.
2001: R Rodriguez; M Matsuda; Olga Perisic; Jerónimo Bravo; A Paul; Neil P Jones; Yvonne Light; Karl Swann; Roger L Williams; Matilda Katan
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
The Journal of biological chemistry 2001;276(51):47982-92.
2001: Jerónimo Bravo; Dimitrios Karathanassis; C M Pacold; Michael E Pacold; Chris D Ellson; Karen E Anderson; P J Butler; I Lavenir; Olga Perisic; Phillip T Hawkins; Len Stephens; Roger L Williams
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
Molecular cell 2001;8(4):829-39.
2000: Michael E Pacold; Sabine Suire; Olga Perisic; S Lara-Gonzalez; Colin T Davis; EH Walker; Phillip T Hawkins; Len Stephens; John F Eccleston; Roger L Williams
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.
Cell 2000;103(6):931-43.
2000: EH Walker; Michael E Pacold; Olga Perisic; Len Stephens; Phillip T Hawkins; Matthias P Wymann; Roger L Williams
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
Molecular cell 2000;6(4):909-19.
1999: EH Walker; Olga Perisic; C Ried; Len Stephens; Roger L Williams
Structural insights into phosphoinositide 3-kinase catalysis and signalling.
Nature 1999;402(6759):313-20.
1999: Olga Perisic; H F Paterson; Georgina Mosedale; S Lara-González; Roger L Williams
Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2.
The Journal of biological chemistry 1999;274(21):14979-87.
1998: M V Ellis; SR James; Olga Perisic; C Peter Downes; Roger L Williams; Matilda Katan
Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1.
The Journal of biological chemistry 1998;273(19):11650-9.
1998: Olga Perisic; S Fong; D E Lynch; Mark Bycroft; Roger L Williams
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2.
The Journal of biological chemistry 1998;273(3):1596-604.
1997: Y Wu; Olga Perisic; Roger L Williams; M Katan; Mary F Roberts
Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation.
Biochemistry 1997;36(37):11223-33.
1997: L O Essen; Olga Perisic; D E Lynch; M Katan; Roger L Williams
A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.
Biochemistry 1997;36(10):2753-62.
1997: L O Essen; Olga Perisic; M Katan; Y Wu; Mary F Roberts; Roger L Williams
Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C.
Biochemistry 1997;36(7):1704-18.
1996: L O Essen; Olga Perisic; R Cheung; M Katan; Roger L Williams
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
Nature 1996;380(6575):595-602.
1995: H F Paterson; John Savopoulos; Olga Perisic; R Cheung; M V Ellis; Roger L Williams; M Katan
Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane.
The Biochemical journal 1995;312 ( Pt 3)():661-6.
1995: P A Webb; Olga Perisic; C E Mendola; J M Backer; Roger L Williams
The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.
Journal of molecular biology 1995;251(4):574-87.
1995: S V Strelkov; Olga Perisic; P A Webb; Roger L Williams
The 1.9 A crystal structure of a nucleoside diphosphate kinase complex with adenosine 3',5'-cyclic monophosphate: evidence for competitive inhibition.
Journal of molecular biology 1995;249(3):665-74.
1994: Olga Perisic; P A Webb; P Holliger; G Winter; Roger L Williams
Crystal structure of a diabody, a bivalent antibody fragment.
Structure (London, England : 1993) 1994;2(12):1217-26.