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Douglas Perkins

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Winnie A Okeyo; Wilson Okumu; John M Ong'echa; Samuel B Anyona; Elly O Munde; Douglas J Perkins; Evans Raballah; John M Vulule; Collins Ouma
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.
Samuel B Anyona; Gregory C Davenport; Charity W Gichuki; James B Hittner; Prakasha Kempaiah; Stephen N Konah; John M Ong'echa; Evans Raballah; John M Vulule; Were Tom; Douglas J Perkins
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.
Prakasha Kempaiah; John M Ong'echa; Samuel B Anyona; Gregory C Davenport; James B Hittner; Evans Raballah; Tom Were; Douglas J Perkins
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.

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2013: Winnie A Okeyo; Wilson Okumu; John M Ong'echa; Samuel B Anyona; Elly O Munde; Douglas J Perkins; Evans Raballah; John M Vulule; Collins Ouma
Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.
BMC immunology 2013;14():15.
2012: Samuel B Anyona; Gregory C Davenport; Charity W Gichuki; James B Hittner; Prakasha Kempaiah; Stephen N Konah; John M Ong'echa; Evans Raballah; John M Vulule; Were Tom; Douglas J Perkins
Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.
American journal of hematology 2012;87(8):782-9.
2012: Prakasha Kempaiah; John M Ong'echa; Samuel B Anyona; Gregory C Davenport; James B Hittner; Evans Raballah; Tom Were; Douglas J Perkins
Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.
Human genetics 2012;131(8):1375-91.
2012: Gregory C Davenport; James B Hittner; John M Ong'echa; Tom Were; Douglas J Perkins
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria.
American journal of hematology 2012;87(7):652-8.
2012: Ariel L Rivas; Jeanne M Fair; Folorunso O Fasina; José L Febles; James B Hittner; Almira L Hoogesteyn; James M Hyman; Steven N Konah; Douglas J Perkins; Steven D Smith
Connecting network properties of rapidly disseminating epizoonotics.
PloS one 2012;7(6):e39778.
2012: Kingsley Badu; Andrew Githeko; John Larbi; John M Ong'echa; Douglas J Perkins; Virginia Ann Stewart; John Waitumbi; Yaw Asare Afrane; Evelina Angov; Guofa Zhou; Guiyun Yan
Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands.
BMC infectious diseases 2012;12():50.
2011: Samuel B Anyona; Gregory C Davenport; Charity W Gichuki; James B Hittner; Prakasha Kempaiah; Stephen N Konah; John M Ong'echa; Collins Ouma; Evans Raballah; John M Vulule; Were Tom; Douglas J Perkins
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
Infection and immunity 2011;79(12):4923-32.
2011: John M Ong'echa; Gregory C Davenport; James B Hittner; John M Vulule; Douglas J Perkins
Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods.
Infection and immunity 2011;79(11):4674-80.
2011: Gordon A Awandare; Prakasha Kempaiah; Daniel O Ochiel; Paolo Piazza; Christopher C Keller; Douglas J Perkins
Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model.
American journal of hematology 2011;86(2):155-62.
2011: Douglas J Perkins; Tom Were; Gregory C Davenport; James B Hittner; Prakasha Kempaiah; John M Ong'echa
Severe malarial anemia: innate immunity and pathogenesis.
International journal of biological sciences 2011;7(9):1427-42.
2011: John M Ong'echa; Collins Ouma; Evans O Raballah; John M Vulule; Tom Were; Samuel B Anyona; Gregory C Davenport; James B Hittner; Prakasha M Kempaiah; Stephen Konah; Douglas J Perkins
Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.
BMC genetics 2011;12():69.
2010: Enrico M Novelli; James B Hittner; Gregory C Davenport; Collins Ouma; Tom Were; Stephen Obaro; Sandra Kaplan; John M Ong'echa; Douglas J Perkins
Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area.
British journal of haematology 2010;149(5):711-21.
2010: Gregory C Davenport; Collins Ouma; James B Hittner; Tom Were; Yamo Ouma; John M Ong'echa; Douglas J Perkins
Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV-1.
American journal of hematology 2010;85(4):227-33.
2009: Christopher C Keller; Collins Ouma; Yamo Ouma; Gordon A Awandare; Gregory C Davenport; Were Tom; James B Hittner; John M Vulule; John M Ong'echa; Douglas J Perkins
Suppression of a novel hematopoietic mediator in children with severe malarial anemia.
Infection and immunity 2009;77(9):3864-71.
2009: Gordon A Awandare; Jeremy Martinson; Were Tom; Collins Ouma; Gregory C Davenport; John M Ong'echa; Wenkui Wang; Lin Leng; Robert E Ferrell; Richard Bucala; Douglas J Perkins
MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.
The Journal of infectious diseases 2009;200(4):629-37.
2008: John M Ong'echa; Allison M Remo; Jan Kristoff; James B Hittner; Were Tom; Collins Ouma; Richard O Otieno; John M Vulule; Christopher C Keller; Gordon A Awandare; Douglas J Perkins
Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10.
Clinical immunology (Orlando, Fla.) 2008;126(2):211-21.
2007: Gordon A Awandare; Song Le; James B Hittner; Christopher C Keller; Ian A Clark; J Brice Weinberg; Douglas J Perkins
Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria.
The American journal of tropical medicine and hygiene 2007;76(6):1033-6.
2007: Gordon A Awandare; Yamo Ouma; Collins Ouma; Were Tom; Richard O Otieno; Christopher C Keller; Gregory C Davenport; James B Hittner; John M Vulule; Robert E Ferrell; John M Ong'echa; Douglas J Perkins
Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia.
Infection and immunity 2007;75(1):201-10.
2006: Were Tom; James B Hittner; Collins Ouma; Richard O Otieno; Alloys S S Orago; John M Ong'echa; John M Vulule; Christopher C Keller; Douglas J Perkins
Suppression of RANTES in children with Plasmodium falciparum malaria.
Haematologica 2006;91(10):1396-9.
2006: Gordon A Awandare; Collins Ouma; Christopher C Keller; Were Tom; Richard O Otieno; Y Ouma; Gregory C Davenport; James B Hittner; John M Ong'echa; Robert E Ferrell; Douglas J Perkins
A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria.
Genes and immunity 2006;7(7):568-75.
2006: Christopher C Keller; Ouma Yamo; Collins Ouma; John M Ong'echa; David Ounah; James B Hittner; John M Vulule; Douglas J Perkins
Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.
Infection and immunity 2006;74(9):5249-60.
2006: Christopher C Keller; Gregory C Davenport; Katherine R Dickman; James B Hittner; Sandra S Kaplan; J Brice Weinberg; Song Le; Douglas J Perkins
Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia.
The Journal of infectious diseases 2006;193(10):1384-93.
2006: Gordon A Awandare; James B Hittner; Song Le; Daniel O Ochiel; Christopher C Keller; J Brice Weinberg; Ian A Clark; Douglas J Perkins
Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria.
Clinical immunology (Orlando, Fla.) 2006;119(2):219-25.
2006: Collins Ouma; Christopher C Keller; Dorothy A Opondo; Were Tom; Richard O Otieno; Michael F Otieno; Alloys S S Orago; John M Ong'echa; John M Vulule; Robert E Ferrell; Douglas J Perkins
Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.
The American journal of tropical medicine and hygiene 2006;74(4):573-7.
2006: John M Ong'echa; Christopher C Keller; Were Tom; Collins Ouma; Richard O Otieno; Zachary Landis-Lewis; Daniel Ochiel; Jamie L Slingluff; Stephen Mogere; George A Ogonji; Alloys S S Orago; John M Vulule; Sandra S Kaplan; Richard D Day; Douglas J Perkins
Parasitemia, anemia, and malarial anemia in infants and young children in a rural holoendemic Plasmodium falciparum transmission area.
The American journal of tropical medicine and hygiene 2006;74(3):376-85.
2006: Richard O Otieno; Collins Ouma; John M Ong'echa; Christopher C Keller; Were Tom; Eliud N Waindi; Marian G Michaels; Richard D Day; John M Vulule; Douglas J Perkins
Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria.
AIDS (London, England) 2006;20(2):275-80.
2005: Benjamin K Nti; Jamie L Slingluff; Christopher C Keller; James B Hittner; John M Ong'echa; Michael Murphey-Corb; Douglas J Perkins
Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-alpha regulation and viral replication.
AIDS (London, England) 2005;19(16):1771-80.
2005: Daniel O Ochiel; Gordon A Awandare; Christopher C Keller; James B Hittner; Song Le; J Brice Weinberg; Douglas J Perkins
Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria.
Infection and immunity 2005;73(7):4190-7.
2005: Douglas J Perkins; James B Hittner; Esther D Mwaikambo; Donald L Granger; J Brice Weinberg; Nicholas Anstey
Impaired systemic production of prostaglandin E2 in children with cerebral malaria.
The Journal of infectious diseases 2005;191(9):1548-57.
2004: Julie M Moore; Sujittra Chaisavaneeyakorn; Douglas J Perkins; Caroline Othoro; Juliana A Otieno; Bernard L Nahlen; Ya Ping Shi; Venkatachalam Udhayakumar
Hemozoin differentially regulates proinflammatory cytokine production in human immunodeficiency virus-seropositive and -seronegative women with placental malaria.
Infection and immunity 2004;72(12):7022-9.
2004: Christopher C Keller; Song Le; James B Hittner; Mary A Misukonis; J Brice Weinberg; Douglas J Perkins
Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells.
Infection and immunity 2004;72(8):4868-73.
2004: Christopher C Keller; James B Hittner; Benjamin K Nti; J Brice Weinberg; Song Le; Douglas J Perkins
Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.
Molecular medicine (Cambridge, Mass.) 2004;10(1-6):45-54.
2003: Douglas J Perkins; Julie M Moore; Juliana A Otieno; Ya Ping Shi; Bernard L Nahlen; Venkatachalam Udhayakumar; Altaf A Lal
In vivo acquisition of hemozoin by placental blood mononuclear cells suppresses PGE2, TNF-alpha, and IL-10.
Biochemical and biophysical research communications 2003;311(4):839-46.
2002: Sujittra Chaisavaneeyakorn; Julie M Moore; Juliana A Otieno; Sansanee C Chaiyaroj; Douglas J Perkins; Ya Ping Shi; Bernard L Nahlen; Altaf A Lal; Venkatachalam Udhayakumar
Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women.
The Journal of infectious diseases 2002;185(1):127-31.
2001: Jürgen Kun; Benjamin Mordmüller; Douglas J Perkins; May Jürgen; O Mercereau-Puijalon; Michael P Alpers; J Brice Weinberg; Song Le
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
The Journal of infectious diseases 2001;184(3):330-6.
2001: Douglas J Perkins; Song Le; J Brice Weinberg
Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria.
The Journal of infectious diseases 2001;183(1):113-8.
2000: Douglas J Perkins; J Brice Weinberg; P G Kremsner
Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity.
The Journal of infectious diseases 2000;182(3):988-92.
2000: Adrian J F Luty; Douglas J Perkins; Bertrand Lell; RJ Schmidt-Ott; Leopold Gustave Lehman; D Luckner; B Greve; P Matousek; K Herbich; D Schmid; J Brice Weinberg; Song Le
Low interleukin-12 activity in severe Plasmodium falciparum malaria.
Infection and immunity 2000;68(7):3909-15.
1999: Marc C Levesque; Maurine R Hobbs; Nicholas Anstey; T N Vaughn; J A Chancellor; Ann Pole; Douglas J Perkins; Mary A Misukonis; STEPHEN CHANOCK; Donald L Granger; J Brice Weinberg
Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.
The Journal of infectious diseases 1999;180(6):1994-2002.
1999: Douglas J Perkins; Song Le; D Schmid; Mary A Misukonis; M A Kelly; J Brice Weinberg
Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria.
Infection and immunity 1999;67(9):4977-81.
1999: Douglas J Perkins; Douglas A Kniss
Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages.
Journal of leukocyte biology 1999;65(6):792-9.
1998: Douglas J Perkins; E W St Clair; Mary A Misukonis; J Brice Weinberg
Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2).
Arthritis and rheumatism 1998;41(12):2205-10.
1997: Ala I Sharara; Douglas J Perkins; Mary A Misukonis; S U Chan; J A Dominitz; J Brice Weinberg
Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo.
The Journal of experimental medicine 1997;186(9):1495-502.
1997: C M Swaisgood; H X Zu; Douglas J Perkins; S Wu; C L Garver; Peter D Zimmerman; Jay D Iams; Douglas A Kniss
Coordinate expression of inducible nitric oxide synthase and cyclooxygenase-2 genes in uterine tissues of endotoxin-treated pregnant mice.
American journal of obstetrics and gynecology 1997;177(5):1253-62.
1997: Douglas J Perkins; Douglas A Kniss
Tumor necrosis factor-alpha promotes sustained cyclooxygenase-2 expression: attenuation by dexamethasone and NSAIDs.
Prostaglandins 1997;54(4):727-43.
1997: Douglas J Perkins; Douglas A Kniss
Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnion-derived WISH cells.
The Biochemical journal 1997;321 ( Pt 3)():677-81.
1992: Werner Tjarks; A K Anisuzzaman; L Liu; Albert H Soloway; Rolf F Barth; Douglas J Perkins; Dianne M Adams
Synthesis and in vitro evaluation of boronated uridine and glucose derivatives for boron neutron capture therapy.
Journal of medicinal chemistry 1992;35(9):1628-33.