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Stephen Perkins

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Phenomena

Genes & Molecular Sequences

Amino Acid Sequence

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Physiology

Protein Folding

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Co-Publications
Name
12
Sim, Robert
10
Saunders, Rebecca
10
Boehm, Mark
10
Haris, PI
9
Holers, Michael
8
Furtado, Patricia
7
Gilbert, Hannah
7
Kerr, Michael
7
Ullman, CG
6
Hinshelwood, J
6
Chamberlain, Dean
6
Eaton, Julian
6
Almogren, Adel
6
Aslam, Mohammed
5
Bruckdorfer, Richard

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Publications

TOP 3
Perkins Stephen J; Okemefuna Azubuike I; Nan Ruodan; Li Keying; Bonner Alexandra
Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights.
Saunders Rebecca E; Shiltagh Nuha; Gomez Keith; Mellars Gillian; Cooper Carolyn; Perry David J; Tuddenham Edward G; Perkins Stephen J
Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.
Okemefuna Azubuike I; Nan Ruodan; Gor Jayesh; Perkins Stephen J
Electrostatic interactions contribute to the folded-back conformation of wild type human factor H.

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All Publications

2009: Perkins Stephen J; Okemefuna Azubuike I; Nan Ruodan; Li Keying; Bonner Alexandra
Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights.
Journal of the Royal Society, Interface / the Royal Society 2009;6 Suppl 5():S679-96.
2009: Saunders Rebecca E; Shiltagh Nuha; Gomez Keith; Mellars Gillian; Cooper Carolyn; Perry David J; Tuddenham Edward G; Perkins Stephen J
Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.
Thrombosis and haemostasis 2009;102(2):287-301.
2009: Okemefuna Azubuike I; Nan Ruodan; Gor Jayesh; Perkins Stephen J
Electrostatic interactions contribute to the folded-back conformation of wild type human factor H.
Journal of molecular biology 2009;391(1):98-118.
2009: Okemefuna Azubuike I; Li Keying; Nan Ruodan; Ormsby Rebecca J; Sadlon Tania; Gordon David L; Perkins Stephen J
Multimeric interactions between complement factor H and its C3d ligand provide new insight on complement regulation.
Journal of molecular biology 2009;391(1):119-35.
2009: Leonard Paul G; Ono Shusuke; Gor Jayesh; Perkins Stephen J; Ladbury John E
Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.
Molecular microbiology 2009;73(2):165-79.
2009: Almogren Adel; Bonner Alexandra; Perkins Stephen J; Kerr Michael A
Functional and structural characterisation of human colostrum free secretory component.
Molecular immunology 2009;46(7):1534-41.
2009: Bonner Alexandra; Almogren Adel; Furtado Patricia B; Kerr Michael A; Perkins Stephen J
The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses.
The Journal of biological chemistry 2009;284(8):5077-87.
2008: Nan Ruodan; Gor Jayesh; Lengyel Imre; Perkins Stephen J
Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator factor H and its possible implications for function and disease.
Journal of molecular biology 2008;384(5):1341-52.
2008: Li Keying; Okemefuna Azubuike I; Gor Jayesh; Hannan Jonathan P; Asokan Rengasamy; Holers V Michael; Perkins Stephen J
Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2.
Journal of molecular biology 2008;384(1):137-50.
2008: Edey Matthew M; Mead Paul A; Saunders Rebecca E; Strain Lisa; Perkins Stephen J; Goodship Timothy H J; Kanagasundaram N Suren
Association of a factor H mutation with hemolytic uremic syndrome following a diarrheal illness.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2008;51(3):487-90.
2008: Saunders Rebecca E; Perkins Stephen J
CoagMDB: a database analysis of missense mutations within four conserved domains in five vitamin K-dependent coagulation serine proteases using a text-mining tool.
Human mutation 2008;29(3):333-44.
2008: Perkins Stephen J; Bonner Alexandra
Structure determinations of human and chimaeric antibodies by solution scattering and constrained molecular modelling.
Biochemical Society transactions 2008;36(Pt 1):37-42.
2008: Bonner Alexandra; Furtado Patricia B; Almogren Adel; Kerr Michael A; Perkins Stephen J
Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1008-18.
2008: Nan Ruodan; Gor Jayesh; Perkins Stephen J
Implications of the progressive self-association of wild-type human factor H for complement regulation and disease.
Journal of molecular biology 2008;375(4):891-900.
2008: Furtado Patricia B; Huang Chen Y; Ihyembe Demvihin; Hammond Russell A; Marsh Henry C; Perkins Stephen J
The partly folded back solution structure arrangement of the 30 SCR domains in human complement receptor type 1 (CR1) permits access to its C3b and C4b ligands.
Journal of molecular biology 2008;375(1):102-18.
2008: Okemefuna Azubuike I; Gilbert Hannah E; Griggs Kim M; Ormsby Rebecca J; Gordon David L; Perkins Stephen J
The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties.
Journal of molecular biology 2008;375(1):80-101.
2008: Perkins Stephen J; Okemefuna Azubuike I; Fernando Anira N; Bonner Alexandra; Gilbert Hannah E; Furtado Patricia B
X-ray and neutron scattering data and their constrained molecular modeling.
Methods in cell biology 2008;84():375-423.
2007: Bonner Alexandra; Perrier Clémentine; Corthésy Blaise; Perkins Stephen J
Solution structure of human secretory component and implications for biological function.
The Journal of biological chemistry 2007;282(23):16969-80.
2007: Fernando Anira N; Furtado Patricia B; Clark Simon J; Gilbert Hannah E; Day Anthony J; Sim Robert B; Perkins Stephen J
Associative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparin.
Journal of molecular biology 2007;368(2):564-81.
2007: Saunders Rebecca E; Abarrategui-Garrido Cynthia; Frémeaux-Bacchi Véronique; Goicoechea de Jorge Elena; Goodship Timothy H J; López Trascasa Margarita; Noris Marina; Ponce Castro Isabel Maria; Remuzzi Giuseppe; Rodríguez de Córdoba Santiago; Sánchez-Corral Pilar; Skerka Christine; Zipfel Peter F; Perkins Stephen J
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models.
Human mutation 2007;28(3):222-34.
2006: Gilbert Hannah E; Asokan Rengasamy; Holers V Michael; Perkins Stephen J
The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions.
Journal of molecular biology 2006;362(5):1132-47.
2006: Clark Simon J; Higman Victoria A; Mulloy Barbara; Perkins Stephen J; Lea Susan M; Sim Robert B; Day Anthony J
His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.
The Journal of biological chemistry 2006;281(34):24713-20.
2006: Licht C; Heinen S; Józsi M; Löschmann I; Saunders R E; Perkins S J; Waldherr R; Skerka C; Kirschfink M; Hoppe B; Zipfel P F
Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II).
Kidney international 2006;70(1):42-50.
2006: Saunders Rebecca E; Perkins Stephen J
A user's guide to the interactive Web database of factor H-associated hemolytic uremic syndrome.
Seminars in thrombosis and hemostasis 2006;32(2):160-8.
2006: Almogren Adel; Furtado Patricia B; Sun Zhe; Perkins Stephen J; Kerr Michael A
Purification, properties and extended solution structure of the complex formed between human immunoglobulin A1 and human serum albumin by scattering and ultracentrifugation.
Journal of molecular biology 2006;356(2):413-31.
2006: Gilbert Hannah E; Aslam Mohammed; Guthridge Joel M; Holers V Michael; Perkins Stephen J
Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Journal of molecular biology 2006;356(2):397-412.
2006: Józsi Mihály; Heinen Stefan; Hartmann Andrea; Ostrowicz Clemens W; Hälbich Steffi; Richter Heiko; Kunert Anja; Licht Christoph; Saunders Rebecca E; Perkins Stephen J; Zipfel Peter F; Skerka Christine
Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.
Journal of the American Society of Nephrology : JASN 2006;17(1):170-7.
2006: Saunders Rebecca E; Goodship Timothy H J; Zipfel Peter F; Perkins Stephen J
An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations.
Human mutation 2006;27(1):21-30.
2005: Sun Zhe; Almogren Adel; Furtado Patricia B; Chowdhury Badrun; Kerr Michael A; Perkins Stephen J
Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering.
Journal of molecular biology 2005;353(1):155-73.
2005: Saunders Rebecca E; O'Connell Niamh M; Lee Christine A; Perry David J; Perkins Stephen J
Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools.
Human mutation 2005;26(3):192-8.
2005: Hu Youli; Sun Zhe; Eaton Julian T; Bouloux Pierre M G; Perkins Stephen J
Extended and flexible domain solution structure of the extracellular matrix protein anosmin-1 by X-ray scattering, analytical ultracentrifugation and constrained modelling.
Journal of molecular biology 2005;350(3):553-70.
2005: von Ossowski Ingemar; Eaton Julian T; Czjzek Mirjam; Perkins Stephen J; Frandsen Torben P; Schülein Martin; Panine Pierre; Henrissat Bernard; Receveur-Bréchot Veronique
Protein disorder: conformational distribution of the flexible linker in a chimeric double cellulase.
Biophysical journal 2005;88(4):2823-32.
2005: Gilbert Hannah E; Eaton Julian T; Hannan Jonathan P; Holers V Michael; Perkins Stephen J
Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.
Journal of molecular biology 2005;346(3):859-73.
2005: O'Connell N M; Saunders R E; Lee C A; Perry D J; Perkins S J
Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling.
Journal of thrombosis and haemostasis : JTH 2005;3(1):127-38.
2004: Deam Susan; Uprichard James; Eaton Julian T; Perkins Stephen J; Dasani Hasmukh; Hanley John; Dolan Gerard
Two new factor X mutations (Pro382Leu and Phe356Cys) associated with low activity and low antigen levels.
Thrombosis and haemostasis 2004;92(5):1161-3.
2004: Sun Zhe; Reid Kenneth B M; Perkins Stephen J
The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.
Journal of molecular biology 2004;343(5):1327-43.
2004: Plevin Michael J; Magalhães Beatriz S; Harris Richard; Sankar Andrew; Perkins Stephen J; Driscoll Paul C
Characterization and manipulation of the Pseudomonas aeruginosa dimethylarginine dimethylaminohydrolase monomer--dimer equilibrium.
Journal of molecular biology 2004;341(1):171-84.
2004: Furtado Patricia B; Whitty Patrick W; Robertson Alexis; Eaton Julian T; Almogren Adel; Kerr Michael A; Woof Jenny M; Perkins Stephen J
Solution structure determination of monomeric human IgA2 by X-ray and neutron scattering, analytical ultracentrifugation and constrained modelling: a comparison with monomeric human IgA1.
Journal of molecular biology 2004;338(5):921-41.
2003: Lee Yie Chia; Flora Rashpal; McCafferty James A; Gor Jayesh; Tsaneva Irina R; Perkins Stephen J
A tetramer-octamer equilibrium in Mycobacterium leprae and Escherichia coli RuvA by analytical ultracentrifugation.
Journal of molecular biology 2003;333(4):677-82.
2003: Idowu Seraphina M; Gautel Mathias; Perkins Stephen J; Pfuhl Mark
Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): implications for multidomain assembly and causes for cardiomyopathy.
Journal of molecular biology 2003;329(4):745-61.
2003: Aslam Mohammed; Guthridge Joel M; Hack Bradley K; Quigg Richard J; Holers V Michael; Perkins Stephen J
The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Journal of molecular biology 2003;329(3):525-50.
2003: Deam S; Uprichard J; Eaton J T; Perkins S J; Dolan G
Factor X Leicester: Ile411Phe associated with a low antigen level and a disproportionately low functional activity of factor X.
Journal of thrombosis and haemostasis : JTH 2003;1(3):603-5.
2002: Perkins S J; Gilbert H E; Aslam M; Hannan J; Holers V M; Goodship T H
Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation.
Biochemical Society transactions 2002;30(Pt 6):996-1001.
2002: Hannan J; Young K; Szakonyi G; Overduin M J; Perkins S J; Chen X; Holers V M
Structure of complement receptor (CR) 2 and CR2-C3d complexes.
Biochemical Society transactions 2002;30(Pt 6):983-9.
2002: Lee Yie Chia; Boehm Mark K; Chester Kerry A; Begent Richard H J; Perkins Stephen J
Reversible dimer formation and stability of the anti-tumour single-chain Fv antibody MFE-23 by neutron scattering, analytical ultracentrifugation, and NMR and FT-IR spectroscopy.
Journal of molecular biology 2002;320(1):107-27.
2002: Peyvandi Flora; Menegatti Marzia; Santagostino Elena; Akhavan Sepideh; Uprichard James; Perry David J; Perkins Stephen J; Mannucci Pier M
Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency.
British journal of haematology 2002;117(3):685-92.
2002: Perkins Stephen J; Goodship Timothy H J
Molecular modelling of the C-terminal domains of factor H of human complement: a correlation between haemolytic uraemic syndrome and a predicted heparin binding site.
Journal of molecular biology 2002;316(2):217-24.
2001: Perkins S J
X-ray and neutron scattering analyses of hydration shells: a molecular interpretation based on sequence predictions and modelling fits.
Biophysical chemistry 2001;93(2-3):129-39.
2001: Guthridge J M; Young K; Gipson M G; Sarrias M R; Szakonyi G; Chen X S; Malaspina A; Donoghue E; James J A; Lambris J D; Moir S A; Perkins S J; Holers V M
Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5758-66.
2001: Robertson A; MacColl G S; Nash J A; Boehm M K; Perkins S J; Bouloux P M
Molecular modelling and experimental studies of mutation and cell-adhesion sites in the fibronectin type III and whey acidic protein domains of human anosmin-1.
The Biochemical journal 2001;357(Pt 3):647-59.
2001: Aslam M; Perkins S J
Folded-back solution structure of monomeric factor H of human complement by synchrotron X-ray and neutron scattering, analytical ultracentrifugation and constrained molecular modelling.
Journal of molecular biology 2001;309(5):1117-38.
2001: Guthridge J M; Rakstang J K; Young K A; Hinshelwood J; Aslam M; Robertson A; Gipson M G; Sarrias M R; Moore W T; Meagher M; Karp D; Lambris J D; Perkins S J; Holers V M
Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg.
Biochemistry 2001;40(20):5931-41.
2000: Nitu-Whalley I C; Riddell A; Lee C A; Pasi K J; Owens D; Enayat M S; Perkins S J; Jenkins P V
Identification of type 2 von Willebrand disease in previously diagnosed type 1 patients: a reappraisal using phenotypes, genotypes and molecular modelling.
Thrombosis and haemostasis 2000;84(6):998-1004.
2000: Akhavan S; Mannucci P M; Lak M; Mancuso G; Mazzucconi M G; Rocino A; Jenkins P V; Perkins S J
Identification and three-dimensional structural analysis of nine novel mutations in patients with prothrombin deficiency.
Thrombosis and haemostasis 2000;84(6):989-97.
2000: Hinshelwood J; Perkins S J
Conformational changes during the assembly of factor B from its domains by (1)H NMR spectroscopy and molecular modelling: their relevance to the regulation of factor B activity.
Journal of molecular biology 2000;301(5):1267-85.
2000: Peyvandi F; Jenkins P V; Mannucci P M; Billio A; Zeinali S; Perkins S J; Perry D J
Molecular characterisation and three-dimensional structural analysis of mutations in 21 unrelated families with inherited factor VII deficiency.
Thrombosis and haemostasis 2000;84(2):250-7.
2000: Boehm M K; Perkins S J
Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23.
FEBS letters 2000;475(1):11-6.
2000: Hinshelwood J; Perkins S J
Metal-dependent conformational changes in a recombinant vWF-A domain from human factor B: a solution study by circular dichroism, fourier transform infrared and (1)H NMR spectroscopy.
Journal of molecular biology 2000;298(1):135-47.
2000: Boehm M K; Corper A L; Wan T; Sohi M K; Sutton B J; Thornton J D; Keep P A; Chester K A; Begent R H; Perkins S J
Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts.
The Biochemical journal 2000;346 Pt 2():519-28.
1999: Perkins S J; Hinshelwood J; Edwards Y J; Jenkins P V
Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation.
Biochemical Society transactions 1999;27(6):815-20.
1999: Hinshelwood J; Spencer D I; Edwards Y J; Perkins S J
Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: implications for the activity of factor B.
Journal of molecular biology 1999;294(2):587-99.
1999: Williams S C; Hinshelwood J; Perkins S J; Sim R B
Production and functional activity of a recombinant von Willebrand factor-A domain from human complement factor B.
The Biochemical journal 1999;342 Pt 3():625-32.
1999: Boehm M K; Woof J M; Kerr M A; Perkins S J
The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling.
Journal of molecular biology 1999;286(5):1421-47.
1998: Chamberlain D; Keeley A; Aslam M; Arenas-Licea J; Brown T; Tsaneva I R; Perkins S J
A synthetic holliday junction is sandwiched between two tetrameric Mycobacterium leprae RuvA structures in solution: new insights from neutron scattering contrast variation and modelling.
Journal of molecular biology 1998;284(2):385-400.
1998: Chamberlain D; Ullman C G; Perkins S J
Possible arrangement of the five domains in human complement factor I as determined by a combination of X-ray and neutron scattering and homology modeling.
Biochemistry 1998;37(40):13918-29.
1998: Ullman C G; Chamberlain D; Ansari A; Emery V C; Haris P I; Sim R B; Perkins S J
Human complement factor I: its expression by insect cells and its biochemical and structural characterisation.
Molecular immunology 1998;35(9):503-12.
1998: Perkins S J; Ullman C G; Brissett N C; Chamberlain D; Boehm M K
Analogy and solution scattering modelling: new structural strategies for the multidomain proteins of complement, cartilage and the immunoglobulin superfamily.
Immunological reviews 1998;163():237-50.
1998: Ashton A W; Boehm M K; Johnson D J; Kemball-Cook G; Perkins S J
The solution structure of human coagulation factor VIIa in its complex with tissue factor is similar to free factor VIIa: a study of a heterodimeric receptor-ligand complex by X-ray and neutron scattering and computational modeling.
Biochemistry 1998;37(22):8208-17.
1998: Jenkins P V; Pasi K J; Perkins S J
Molecular modeling of ligand and mutation sites of the type A domains of human von Willebrand factor and their relevance to von Willebrand's disease.
Blood 1998;91(6):2032-44.
1998: Perkins S J; Ashton A W; Boehm M K; Chamberlain D
Molecular structures from low angle X-ray and neutron scattering studies.
International journal of biological macromolecules 1998;22(1):1-16.
1998: Brissett N C; Perkins S J
Conserved basic residues in the C-type lectin and short complement repeat domains of the G3 region of proteoglycans.
The Biochemical journal 1998;329 ( Pt 2)():415-24.
1997: Ullman C G; Perkins S J
The Factor I and follistatin domain families: the return of a prodigal son.
The Biochemical journal 1997;326 ( Pt 3)():939-41.
1997: Ashton A W; Boehm M K; Gallimore J R; Pepys M B; Perkins S J
Pentameric and decameric structures in solution of serum amyloid P component by X-ray and neutron scattering and molecular modelling analyses.
Journal of molecular biology 1997;272(3):408-22.
1997: Chamberlain D; O'Hara B P; Wilson S A; Pearl L H; Perkins S J
Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling.
Biochemistry 1997;36(26):8020-9.
1996: Ullman C G; Haris P I; Galloway D A; Emery V C; Perkins S J
Predicted alpha-helix/beta-sheet secondary structures for the zinc-binding motifs of human papillomavirus E7 and E6 proteins by consensus prediction averaging and spectroscopic studies of E7.
The Biochemical journal 1996;319 ( Pt 1)():229-39.
1996: Meyer D F; Nealis A S; Macphee C H; Groot P H; Suckling K E; Bruckdorfer K R; Perkins S J
Time-course studies by synchrotron X-ray solution scattering of the structure of human low-density lipoprotein during Cu(2+)-induced oxidation in relation to changes in lipid composition.
The Biochemical journal 1996;319 ( Pt 1)():217-27.
1996: Edwards Y J; Perkins S J
Assessment of protein fold predictions from sequence information: the predicted alpha/beta doubly wound fold of the von Willebrand factor type A domain is similar to its crystal structure.
Journal of molecular biology 1996;260(2):277-85.
1996: Brissett N C; Perkins S J
The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily.
FEBS letters 1996;388(2-3):211-6.
1996: Boehm M K; Mayans M O; Thornton J D; Begent R H; Keep P A; Perkins S J
Extended glycoprotein structure of the seven domains in human carcinoembryonic antigen by X-ray and neutron solution scattering and an automated curve fitting procedure: implications for cellular adhesion.
Journal of molecular biology 1996;259(4):718-36.
1996: Brissett N C; Perkins S J
Molecular modelling analyses of the C-type lectin domain in human aggrecan.
Biochemical Society transactions 1996;24(1):99S.
1995: Ashton A W; Kemball-Cook G; Johnson D J; Martin D M; O'Brien D P; Tuddenham E G; Perkins S J
Factor VIIa and the extracellular domains of human tissue factor form a compact complex: a study by X-ray and neutron solution scattering.
FEBS letters 1995;374(1):141-6.
1995: Mayans M O; Coadwell W J; Beale D; Symons D B; Perkins S J
Demonstration by pulsed neutron scattering that the arrangement of the Fab and Fc fragments in the overall structures of bovine IgG1 and IgG2 in solution is similar.
The Biochemical journal 1995;311 ( Pt 1)():283-91.
1995: Ullman C G; Haris P I; Smith K F; Sim R B; Emery V C; Perkins S J
Beta-sheet secondary structure of an LDL receptor domain from complement factor I by consensus structure predictions and spectroscopy.
FEBS letters 1995;371(2):199-203.
1995: Meyer D F; Mayans M O; Groot P H; Suckling K E; Bruckdorfer K R; Perkins S J
Time-course studies by neutron solution scattering and biochemical assays of the aggregation of human low-density lipoprotein during Cu(2+)-induced oxidation.
The Biochemical journal 1995;310 ( Pt 2)():417-26.
1995: Meyer D F; Nealis A S; Bruckdorfer K R; Perkins S J
Characterization of the structure of polydisperse human low-density lipoprotein by neutron scattering.
The Biochemical journal 1995;310 ( Pt 2)():407-15.
1995: Edwards Y J; Perkins S J
The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted beta-sheet flanked by alpha-helices found in human ras-p21.
FEBS letters 1995;358(3):283-6.
1994: Ullman C G; Haris P I; Kell B; Cason J; Jewers R J; Best J M; Emery V C; Perkins S J
Hypothetical structure of the membrane-associated E5 oncoprotein of human papillomavirus type 16.
Biochemical Society transactions 1994;22(4):439S.
1994: Smith K F; Haris P I; Chapman D; Reid K B; Perkins S J
Beta-sheet secondary structure of the trimeric globular domain of C1q of complement and collagen types VIII and X by Fourier-transform infrared spectroscopy and averaged structure predictions.
The Biochemical journal 1994;301 ( Pt 1)():249-56.
1994: Perkins S J; Smith K F; Williams S C; Haris P I; Chapman D; Sim R B
The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions.
Journal of molecular biology 1994;238(1):104-19.
1994: Perkins S J
High-flux X-ray and neutron solution scattering.
Methods in molecular biology (Clifton, N.J.) 1994;22():39-60.
1993: Perkins S J
Three-dimensional structure and molecular modelling of C1- inhibitor.
Behring Institute Mitteilungen 1993;(93):63-80.
1993: Perkins S J; Smith K F; Kilpatrick J M; Volanakis J E; Sim R B
Modelling of the serine-proteinase fold by X-ray and neutron scattering and sedimentation analyses: occurrence of the fold in factor D of the complement system.
The Biochemical journal 1993;295 ( Pt 1)():87-99.
1993: Perkins S J; Smith K F
Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures.
The Biochemical journal 1993;295 ( Pt 1)():109-14.
1993: Perkins S J; Smith K F; Sim R B
Molecular modelling of the domain structure of factor I of human complement by X-ray and neutron solution scattering.
The Biochemical journal 1993;295 ( Pt 1)():101-8.
1993: Meyer D F; Nealis A S; Bruckdorfer K R; Perkins S J
Conformational changes in oxidized LDL using X-ray and neutron solution scattering techniques.
Biochemical Society transactions 1993;21(2):139S.
1992: Perkins S J; Smith K F; Nealis A S; Haris P I; Chapman D; Bauer C J; Harrison R A
Secondary structure changes stabilize the reactive-centre cleaved form of SERPINs. A study by 1H nuclear magnetic resonance and Fourier transform infrared spectroscopy.
Journal of molecular biology 1992;228(4):1235-54.
1992: Perkins S J; Nealis A S; Dunham D G; Hardingham T E; Muir I H
Neutron and X-ray solution-scattering studies of the ternary complex between proteoglycan-binding region, link protein and hyaluronan.
The Biochemical journal 1992;285 ( Pt 1)():263-8.
1992: Smith K F; Harrison R A; Perkins S J
Molecular modeling of the domain structure of C9 of human complement by neutron and X-ray solution scattering.
Biochemistry 1992;31(3):754-64.
1991: Perkins S J; Nealis A S; Dunham D G; Hardingham T E; Muir I H
Molecular modeling of the multidomain structures of the proteoglycan binding region and the link protein of cartilage by neutron and synchrotron X-ray scattering.
Biochemistry 1991;30(44):10708-16.
1991: Perkins S J; Nealis A S; Sutton B J; Feinstein A
Solution structure of human and mouse immunoglobulin M by synchrotron X-ray scattering and molecular graphics modelling. A possible mechanism for complement activation.
Journal of molecular biology 1991;221(4):1345-66.
1991: Smith K F; Nolan K F; Reid K B; Perkins S J
Neutron and X-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat.
Biochemistry 1991;30(32):8000-8.
1991: Tysoe-Calnon V A; Grundy J E; Perkins S J
Molecular comparisons of the beta 2-microglobulin-binding site in class I major-histocompatibility-complex alpha-chains and proteins of related sequences.
The Biochemical journal 1991;277 ( Pt 2)():359-69.
1991: Perkins S J; Nealis A S; Sim R B
Oligomeric domain structure of human complement factor H by X-ray and neutron solution scattering.
Biochemistry 1991;30(11):2847-57.
1990: Perkins S J; Smith K F; Nealis A S
Molecular modelling strategies in application to complement.
Biochemical Society transactions 1990;18(6):1151-4.
1990: Perkins S J
Hydrodynamic data show that C1- inhibitor of complement forms compact complexes with C1-r and C1-s.
FEBS letters 1990;271(1-2):89-92.
1990: Tysoe-Calnon V A; Grundy J E; Nealis A S; Perkins S J
High conservation of beta 2-microglobulin contact residues among 82 class I major histocompatability complex alpha-chain sequences.
Biochemical Society transactions 1990;18(5):930-1.
1990: Perkins S J; Smith K F; Amatayakul S; Ashford D; Rademacher T W; Dwek R A; Lachmann P J; Harrison R A
Two-domain structure of the native and reactive centre cleaved forms of C1 inhibitor of human complement by neutron scattering.
Journal of molecular biology 1990;214(3):751-63.
1990: Smith K F; Harrison R A; Perkins S J
Structural comparisons of the native and reactive-centre-cleaved forms of alpha 1-antitrypsin by neutron- and X-ray-scattering in solution.
The Biochemical journal 1990;267(1):203-12.
1990: Haris P I; Chapman D; Harrison R A; Smith K F; Perkins S J
Conformational transition between native and reactive center cleaved forms of alpha 1-antitrypsin by Fourier transform infrared spectroscopy and small-angle neutron scattering.
Biochemistry 1990;29(6):1377-80.
1990: Perkins S J; Smith K F; Nealis A S; Lachmann P J; Harrison R A
Structural homologies of component C5 of human complement with components C3 and C4 by neutron scattering.
Biochemistry 1990;29(5):175-80.
1990: Perkins S J; Nealis A S; Sim R B
Molecular modeling of human complement component C4 and its fragments by X-ray and neutron solution scattering.
Biochemistry 1990;29(5):1167-75.
1990: Sim R B; Perkins S J
Molecular modelling of C3 and its ligands.
Current topics in microbiology and immunology 1990;153():209-22.
1989: Perkins S J; Nealis A S
The quaternary structure in solution of human complement subcomponent C1r2C1s2.
The Biochemical journal 1989;263(2):463-9.
1989: Perkins S J; Nealis A S; Haris P I; Chapman D; Goundis D; Reid K B
Secondary structure in properdin of the complement cascade and related proteins: a study by Fourier transform infrared spectroscopy.
Biochemistry 1989;28(18):7176-82.
1989: Bellamy M F; Nealis A S; Aitken J W; Bruckdorfer K R; Perkins S J
Structural changes in oxidised low-density lipoproteins and of the effect of the anti-atherosclerotic drug probucol observed by synchrotron X-ray and neutron solution scattering.
European journal of biochemistry / FEBS 1989;183(2):321-9.
1989: Perkins S J
Models for the C1 complex determined by physical techniques.
Behring Institute Mitteilungen 1989;(84):129-41.
1989: Perkins S J; Nealis A S; Dudhia J; Hardingham T E
Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein.
Journal of molecular biology 1989;206(4):737-53.
1988: Perkins S J
Structural studies of proteins by high-flux X-ray and neutron solution scattering.
The Biochemical journal 1988;254(2):313-27.
1988: Perkins S J; Haris P I; Sim R B; Chapman D
A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods.
Biochemistry 1988;27(11):4004-12.

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