FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Philip Perlman

Research Profile

Chemicals & Drugs

Living Beings

Saccharomyces cerevisiae

Physiology

Concepts & Ideas

Anatomy

Mitochondrion

Genes & Molecular Sequences

Genes, Fungal

Co-author Network

Publications

TOP 3
Sabine Mohr; Manabu Matsuura; Philip S Perlman; Alan M Lambowitz
A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone.
Hon-Ren Huang; Claire E Rowe; Sabine Mohr; Yue Jiang; Alan M Lambowitz; Philip S Perlman
The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.
Lorna Dickson; Stuart Connell; Hon-Ren Huang; R Michael Henke; Lu Liu; Philip S Perlman
Abortive transposition by a group II intron in yeast mitochondria.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Philip Perlman (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2006: Sabine Mohr; Manabu Matsuura; Philip S Perlman; Alan M Lambowitz
A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3569-74.
2005: Hon-Ren Huang; Claire E Rowe; Sabine Mohr; Yue Jiang; Alan M Lambowitz; Philip S Perlman
The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(1):163-8.
2004: Lorna Dickson; Stuart Connell; Hon-Ren Huang; R Michael Henke; Lu Liu; Philip S Perlman
Abortive transposition by a group II intron in yeast mitochondria.
Genetics 2004;168(1):77-87.
2004: Philip S Perlman; Jef Boeke
Molecular biology. Ring around the retroelement.
Science (New York, N.Y.) 2004;303(5655):182-4.
2003: Hon-Ren Huang; Michael Y Chao; Barbara Armstrong; Yong Wang; Alan M Lambowitz; Philip S Perlman
The DIVa maturase binding site in the yeast group II intron aI2 is essential for intron homing but not for in vivo splicing.
Molecular and cellular biology 2003;23(23):8809-19.
2003: Brett A Kaufman; Jill E Kolesar; Philip S Perlman; Ronald A Butow
A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae.
The Journal of cell biology 2003;163(3):457-61.
2002: Joseph M Bateman; Michelina Iacovino; Philip S Perlman; Ronald A Butow
Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease.
The Journal of biological chemistry 2002;277(49):47946-53.
2002: Mircea Podar; Lauren Mullineaux; Hon-Ren Huang; Philip S Perlman; Mitchell L Sogin
Bacterial group II introns in a deep-sea hydrothermal vent environment.
Applied and environmental microbiology 2002;68(12):6392-8.
2002: Joseph M Bateman; Philip S Perlman; Ronald A Butow
Mutational bisection of the mitochondrial DNA stability and amino acid biosynthetic functions of ilv5p of budding yeast.
Genetics 2002;161(3):1043-52.
2002: Brett A Kaufman; Scott M Newman; Philip S Perlman; Ronald A Butow
Crosslinking of proteins to mtDNA.
Methods in molecular biology (Clifton, N.J.) 2002;197():377-89.
2001: V T Chu; Catherine Adamidi; Q Liu; Philip S Perlman; Anna Marie Pyle
Control of branch-site choice by a group II intron.
The EMBO journal 2001;20(23):6866-76.
2001: Lorna Dickson; Hon-Ren Huang; Lu Liu; M Matsuura; Alan M Lambowitz; Philip S Perlman
Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13207-12.
2001: DM MacAlpine; J Kolesar; K Okamoto; Ronald A Butow; Philip S Perlman
Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA.
The EMBO journal 2001;20(7):1807-17.
2001: K Okamoto; Philip S Perlman; Ronald A Butow
Targeting of green fluorescent protein to mitochondria.
Methods in cell biology 2001;65():277-83.
2000: R Eskes; Lu Liu; H Ma; M Y Chao; Lorna Dickson; Alan M Lambowitz; Philip S Perlman
Multiple homing pathways used by yeast mitochondrial group II introns.
Molecular and cellular biology 2000;20(22):8432-46.
2000: Brett A Kaufman; Scott M Newman; R L Hallberg; C A Slaughter; Philip S Perlman; Ronald A Butow
In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7772-7.
2000: DM MacAlpine; Philip S Perlman; Ronald A Butow
The numbers of individual mitochondrial DNA molecules and mitochondrial DNA nucleoids in yeast are co-regulated by the general amino acid control pathway.
The EMBO journal 2000;19(4):767-75.
1999: Steven Zimmerly; John V Moran; Philip S Perlman; Alan M Lambowitz
Group II intron reverse transcriptase in yeast mitochondria. Stabilization and regulation of reverse transcriptase activity by the intron RNA.
Journal of molecular biology 1999;289(3):473-90.
1999: Mircea Podar; Philip S Perlman
Photocrosslinking of 4-thio uracil-containing RNAs supports a side-by-side arrangement of domains 5 and 6 of a group II intron.
RNA (New York, N.Y.) 1999;5(2):318-29.
1998: V T Chu; Q Liu; Mircea Podar; Philip S Perlman; Anna Marie Pyle
More than one way to splice an RNA: branching without a bulge and splicing without branching in group II introns.
RNA (New York, N.Y.) 1998;4(10):1186-202.
1998: U Schmidt; I Maue; K Lehmann; S M Belcher; Ulf Stahl; Philip S Perlman
Mutant alleles of the MRS2 gene of yeast nuclear DNA suppress mutations in the catalytic core of a mitochondrial group II intron.
Journal of molecular biology 1998;282(3):525-41.
1998: J Yang; G Mohr; Philip S Perlman; Alan M Lambowitz
Group II intron mobility in yeast mitochondria: target DNA-primed reverse transcription activity of aI1 and reverse splicing into DNA transposition sites in vitro.
Journal of molecular biology 1998;282(3):505-23.
1998: K Okamoto; Philip S Perlman; Ronald A Butow
The sorting of mitochondrial DNA and mitochondrial proteins in zygotes: preferential transmission of mitochondrial DNA to the medial bud.
The Journal of cell biology 1998;142(3):613-23.
1998: Mircea Podar; Philip S Perlman; R A Padgett
The two steps of group II intron self-splicing are mechanistically distinguishable.
RNA (New York, N.Y.) 1998;4(8):890-900.
1998: DM MacAlpine; Philip S Perlman; Ronald A Butow
The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6739-43.
1998: O Zelenaya-Troitskaya; Scott M Newman; K Okamoto; Philip S Perlman; Ronald A Butow
Functions of the high mobility group protein, Abf2p, in mitochondrial DNA segregation, recombination and copy number in Saccharomyces cerevisiae.
Genetics 1998;148(4):1763-76.
1998: Mircea Podar; V T Chu; Anna Marie Pyle; Philip S Perlman
Group II intron splicing in vivo by first-step hydrolysis.
Nature 1998;391(6670):915-8.
1998: Mircea Podar; J Zhuo; M Zhang; J S Franzen; Philip S Perlman; C L Peebles
Domain 5 binds near a highly conserved dinucleotide in the joiner linking domains 2 and 3 of a group II intron.
RNA (New York, N.Y.) 1998;4(2):151-66.
1997: H Guo; Steven Zimmerly; Philip S Perlman; Alan M Lambowitz
Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA.
The EMBO journal 1997;16(22):6835-48.
1997: R Eskes; J Yang; Alan M Lambowitz; Philip S Perlman
Mobility of yeast mitochondrial group II introns: engineering a new site specificity and retrohoming via full reverse splicing.
Cell 1997;88(6):865-74.
1996: U Schmidt; Mircea Podar; Ulf Stahl; Philip S Perlman
Mutations of the two-nucleotide bulge of D5 of a group II intron block splicing in vitro and in vivo: phenotypes and suppressor mutations.
RNA (New York, N.Y.) 1996;2(11):1161-72.
1996: S C Boulanger; P H Faix; H Yang; J Zhuo; J S Franzen; C L Peebles; Philip S Perlman
Length changes in the joining segment between domains 5 and 6 of a group II intron inhibit self-splicing and alter 3' splice site selection.
Molecular and cellular biology 1996;16(10):5896-904.
1996: J Yang; Steven Zimmerly; Philip S Perlman; Alan M Lambowitz
Efficient integration of an intron RNA into double-stranded DNA by reverse splicing.
Nature 1996;381(6580):332-5.
1996: S M Newman; O Zelenaya-Troitskaya; Philip S Perlman; Ronald A Butow
Analysis of mitochondrial DNA nucleoids in wild-type and a mutant strain of Saccharomyces cerevisiae that lacks the mitochondrial HMG box protein Abf2p.
Nucleic acids research 1996;24(2):386-93.
1996: Philip S Perlman; Mircea Podar
Reactions catalyzed by group II introns in vitro.
Methods in enzymology 1996;264():66-86.
1996: Ronald A Butow; R M Henke; John V Moran; S M Belcher; Philip S Perlman
Transformation of Saccharomyces cerevisiae mitochondria using the biolistic gun.
Methods in enzymology 1996;264():265-78.
1995: Steven Zimmerly; H Guo; R Eskes; J Yang; Philip S Perlman; Alan M Lambowitz
A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility.
Cell 1995;83(4):529-38.
1995: R M Henke; Ronald A Butow; Philip S Perlman
Maturase and endonuclease functions depend on separate conserved domains of the bifunctional protein encoded by the group I intron aI4 alpha of yeast mitochondrial DNA.
The EMBO journal 1995;14(20):5094-9.
1995: Mircea Podar; S Dib-Hajj; Philip S Perlman
A UV-induced, Mg(2+)-dependent crosslink traps an active form of domain 3 of a self-splicing group II intron.
RNA (New York, N.Y.) 1995;1(8):828-40.
1995: Steven Zimmerly; H Guo; Philip S Perlman; Alan M Lambowitz
Group II intron mobility occurs by target DNA-primed reverse transcription.
Cell 1995;82(4):545-54.
1995: S C Boulanger; S M Belcher; U Schmidt; S D Dib-Hajj; T Schmidt; Philip S Perlman
Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron.
Molecular and cellular biology 1995;15(8):4479-88.
1995: Mircea Podar; Philip S Perlman; R A Padgett
Stereochemical selectivity of group II intron splicing, reverse splicing, and hydrolysis reactions.
Molecular and cellular biology 1995;15(8):4466-78.
1995: O Zelenaya-Troitskaya; Philip S Perlman; Ronald A Butow
An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability.
The EMBO journal 1995;14(13):3268-76.
1995: W W Guo; John V Moran; P W Hoffman; R M Henke; Ronald A Butow; Philip S Perlman
The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase.
The Journal of biological chemistry 1995;270(26):15563-70.
1995: C L Peebles; M Zhang; Philip S Perlman; J S Franzen
Catalytically critical nucleotide in domain 5 of a group II intron.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4422-6.
1995: John V Moran; Steven Zimmerly; R Eskes; J C Kennell; Alan M Lambowitz; Ronald A Butow; Philip S Perlman
Mobile group II introns of yeast mitochondrial DNA are novel site-specific retroelements.
Molecular and cellular biology 1995;15(5):2828-38.
1994: R A Padgett; Mircea Podar; S C Boulanger; Philip S Perlman
The stereochemical course of group II intron self-splicing.
Science (New York, N.Y.) 1994;266(5191):1685-8.
1994: John V Moran; K L Mecklenburg; P Sass; S M Belcher; D Mahnke; A Lewin; Philip S Perlman
Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2.
Nucleic acids research 1994;22(11):2057-64.
1993: G Mohr; Philip S Perlman; Alan M Lambowitz
Evolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase function.
Nucleic acids research 1993;21(22):4991-7.
1993: C L Peebles; S M Belcher; M Zhang; R C Dietrich; Philip S Perlman
Mutation of the conserved first nucleotide of a group II intron from yeast mitochondrial DNA reduces the rate but allows accurate splicing.
The Journal of biological chemistry 1993;268(16):11929-38.
1993: S D Dib-Hajj; S C Boulanger; S K Hebbar; C L Peebles; J S Franzen; Philip S Perlman
Domain 5 interacts with domain 6 and influences the second transesterification reaction of group II intron self-splicing.
Nucleic acids research 1993;21(8):1797-804.
1993: J C Kennell; John V Moran; Philip S Perlman; Ronald A Butow; Alan M Lambowitz
Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria.
Cell 1993;73(1):133-46.
1992: John V Moran; C M Wernette; K L Mecklenburg; Ronald A Butow; Philip S Perlman
Intron 5 alpha of the COXI gene of yeast mitochondrial DNA is a mobile group I intron.
Nucleic acids research 1992;20(15):4069-76.
1992: J L Koch; S C Boulanger; S D Dib-Hajj; S K Hebbar; Philip S Perlman
Group II introns deleted for multiple substructures retain self-splicing activity.
Molecular and cellular biology 1992;12(5):1950-8.
1992: S K Hebbar; S M Belcher; Philip S Perlman
A maturase-encoding group IIA intron of yeast mitochondria self-splices in vitro.
Nucleic acids research 1992;20(7):1747-54.
1992: C Wernette; R Saldanha; David I Smith; D Ming; Philip S Perlman; Ronald A Butow
Complex recognition site for the group I intron-encoded endonuclease I-SceII.
Molecular and cellular biology 1992;12(4):1903.
1992: C Wernette; R Saldanha; David I Smith; D Ming; Philip S Perlman; Ronald A Butow
Complex recognition site for the group I intron-encoded endonuclease I-SceII.
Molecular and cellular biology 1992;12(2):716-23.
1990: C M Wernette; R Saldahna; Philip S Perlman; Ronald A Butow
Purification of a site-specific endonuclease, I-Sce II, encoded by intron 4 alpha of the mitochondrial coxI gene of Saccharomyces cerevisiae.
The Journal of biological chemistry 1990;265(31):18976-82.
1990: J M Wenzlau; Philip S Perlman
Mobility of two optional G + C-rich clusters of the var1 gene of yeast mitochondrial DNA.
Genetics 1990;126(1):53-62.
1990: P Q Anziano; John V Moran; D Gerber; Philip S Perlman
Novel hybrid maturases in unstable pseudorevertants of maturaseless mutants of yeast mitochondrial DNA.
Nucleic acids research 1990;18(11):3233-9.
1990: H Conrad-Webb; Philip S Perlman; H Zhu; Ronald A Butow
The nuclear SUV3-1 mutation affects a variety of post-transcriptional processes in yeast mitochondria.
Nucleic acids research 1990;18(6):1369-76.
1989: Philip S Perlman; Ronald A Butow
Mobile introns and intron-encoded proteins.
Science (New York, N.Y.) 1989;246(4934):1106-9.
1989: H Zhu; H Conrad-Webb; X S Liao; Philip S Perlman; Ronald A Butow
Functional expression of a yeast mitochondrial intron-encoded protein requires RNA processing at a conserved dodecamer sequence at the 3' end of the gene.
Molecular and cellular biology 1989;9(4):1507-12.
1989: J M Wenzlau; R J Saldanha; Ronald A Butow; Philip S Perlman
A latent intron-encoded maturase is also an endonuclease needed for intron mobility.
Cell 1989;56(3):421-30.
1989: Ronald A Butow; H Zhu; Philip S Perlman; H Conrad-Webb
The role of a conserved dodecamer sequence in yeast mitochondrial gene expression.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1989;31(2):757-60.
1988: K A Jarrell; R C Dietrich; Philip S Perlman
Group II intron domain 5 facilitates a trans-splicing reaction.
Molecular and cellular biology 1988;8(6):2361-6.
1988: Andrew R Zinn; J K Pohlman; Philip S Perlman; Ronald A Butow
In vivo double-strand breaks occur at recombinogenic G + C-rich sequences in the yeast mitochondrial genome.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(8):2686-90.
1988: K A Jarrell; C L Peebles; R C Dietrich; S L Romiti; Philip S Perlman
Group II intron self-splicing. Alternative reaction conditions yield novel products.
The Journal of biological chemistry 1988;263(7):3432-9.
1987: C L Peebles; E J Benatan; K A Jarrell; Philip S Perlman
Group II intron self-splicing: development of alternative reaction conditions and identification of a predicted intermediate.
Cold Spring Harbor symposia on quantitative biology 1987;52():223-32.
1986: C L Peebles; Philip S Perlman; K L Mecklenburg; M L Petrillo; J H Tabor; K A Jarrell; H L Cheng
A self-splicing RNA excises an intron lariat.
Cell 1986;44(2):213-23.
1986: Philip S Perlman; K A Jarrell; R C Dietrich; C L Peebles; S L Romiti; E J Benatan
Mitochondrial gene expression in yeast: further studies of a self-splicing group II intron.
Basic life sciences 1986;40():39-55.
1983: M R Lamb; P Q Anziano; K R Glaus; D K Hanson; H J Klapper; Philip S Perlman; H R Mahler
Functional domains in introns. RNA processing intermediates in cis- and trans-acting mutants in the penultimate intron of the mitochondrial gene for cytochrome b.
The Journal of biological chemistry 1983;258(3):1991-9.
1983: Philip S Perlman; H R Mahler
Genetics and biogenesis of cytochrome b.
Methods in enzymology 1983;97():374-95.
1982: P Q Anziano; D K Hanson; H R Mahler; Philip S Perlman
Functional domains in introns: trans-acting and cis-acting regions of intron 4 of the cob gene.
Cell 1982;30(3):925-32.
1982: D K Hanson; M R Lamb; H R Mahler; Philip S Perlman
Evidence for translated intervening sequences in the mitochondrial genome of Saccharomyces cerevisiae.
The Journal of biological chemistry 1982;257(6):3218-24.
1981: S Dhawale; D K Hanson; N J Alexander; Philip S Perlman; H R Mahler
Regulatory interactions between mitochondrial genes: interactions between two mosaic genes.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(3):1778-82.